TCM Prescription: Bitter Seng Itching Stoper Decoction



Prescription Description
Prescription IDTCMF2009
Pinyin NameKu Shen Zhi Yang Tang
Chinese Name苦参止痒汤
English NameBitter Seng Itching Stoper Decoction
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1215 Sophora flavescens 苦参 TCMH1215 ITSAM449-14
TCMH112 Dictamnus albus 白藓皮 TCMH112 GBVK982-11
TCMH1866 Cnidium monnieri 蛇床子 TCMH1866 ITSAL2575-14
TCMH183 Dryobalanops aromatica 冰片 TCMH183 GBVK4926-11
TCMH562 Saposhnikovia divaricata 防风 TCMH562 ITSAE3225-14
TCMH1141 Schizonepeta tenuifolia 荆芥 TCMH1141 ITSAL858-14
TCMH924 Zanthoxylum bungeanum 花椒 TCMH924 ITSAJ4650-14
TCMH2124 Speranskia tuberculata 透骨草 TCMH2124
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT167 AKR1C3 Aldo-keto-reductase family 1 member C3 Oxidoreductase P42330
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT226 PDPK1 3-phosphoinositide dependent protein kinase-1 Kinase O15530
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1354 Streptococcus mutans UA159
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1449 Influenza A virus
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1C3, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, FABP4, HSD17B1, KIT, MET, MIF, PPARA 7.69868
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1C3, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 7.15598
[BP] GO:0033993 response to lipid AKR1C3, ALPL, AXL, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FLT3, IDO1, RORC, SRC 7.15598
[BP] GO:0010033 response to organic substance AKR1B1, AKR1C3, ALPL, AXL, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP4, FLT3, IDO1, IGF1R, KDR, KIT, PPARA, RORC, SRC 7.13739
[BP] GO:0033559 unsaturated fatty acid metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF 6.9874
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AKR1C3, AURKB, AXL, CNR1, CSNK2A1, CYP1B1, ESR1, FLT3, IDO1, IGF1R, KDR, KIT, MET, MIF, PIM1, PPARA, SRC, XDH 6.918
[BP] GO:0006690 icosanoid metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF 6.89337
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AKR1C3, ALPL, AXL, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, IDO1, IGF1R, PPARA, RORC, SRC 6.89337
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AKR1C3, AURKB, AXL, CNR1, CSNK2A1, CYP1B1, ESR1, FLT3, IDO1, IGF1R, KDR, KIT, MET, MIF, PIM1, SRC, XDH 6.70448
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.98691
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1C3, ALOX5, AOX1, CA12, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, IDO1, MIF, PIM1, PPARA, XDH 5.94802
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, AURKB, AXL, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP4, IDO1, IGF1R, KDR, KIT, MET, MIF, MMP12, PIM1, PPARA, RORC, SRC, XDH 5.86792
[BP] GO:0042221 response to chemical AKR1B1, AKR1C3, ALPL, AXL, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP4, FLT3, IDO1, IGF1R, KDR, KIT, PPARA, RORC, SRC 5.86257
[BP] GO:1901568 fatty acid derivative metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF 5.86257
[BP] GO:0019369 arachidonic acid metabolic process AKR1C3, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.78836
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, HSD17B1 5.62474
[BP] GO:0014070 response to organic cyclic compound AKR1C3, ALPL, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, RORC, SRC 5.59898
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, AKR1C3, CSNK2A1, CYP1B1, ESR1, ESRRA, FLT3, IDO1, IGF1R, KDR, KIT, MIF, MMP12, PIM1, SRC, XDH 5.59898
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1 5.59724
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, RORC, SRC 5.56224
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1 5.40907
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AKR1C3, AURKB, AXL, CNR1, CSNK2A1, CYP1B1, ESR1, FLT3, IDO1, IGF1R, KDR, MIF, PIM1, SRC, XDH 5.33849
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, IDO1, IGF1R, KDR, KIT, MET, MIF, PIM1, PPARA, SRC 5.29377
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, KIT, PIM1, SRC 5.26739
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1C3, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP4, KIT, MET, MIF, PPARA 5.23985
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, AKR1C3, AURKB, AXL, CA7, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FLT3, IDO1, IGF1R, KDR, KIT, MET, MIF, MMP12, PIM1, PPARA, RORC, SRC, XDH 5.20296
[BP] GO:0009725 response to hormone AKR1B1, AKR1C3, ALPL, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FLT3, KIT, PPARA, SRC 5.19539
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, AKR1C3, AURKB, AXL, CA12, CA7, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, HSD17B1, KDR, KIT, MET, MIF, PPARA, SRC, XDH 5.19539
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 5.18798
[BP] GO:0006631 fatty acid metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF, PPARA 5.17479
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, AURKB, AXL, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP4, IDO1, IGF1R, KDR, KIT, MET, MIF, MMP12, PIM1, PPARA, RORC, SRC, XDH 5.13785
[BP] GO:0048513 animal organ development ACHE, AKR1C3, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, KDR, KIT, PPARA, SRC 5.09337
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, IDO1, IGF1R, KDR, KIT, MET, MIF, PIM1, SRC 4.91291
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1C3, ALOX5, ALPL, AOX1, AURKB, AXL, CA12, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, FABP4, FLT3, HSD17B1, IDO1, IGF1R, KDR, KIT, MET, MIF, MMP12, PIM1, PPARA, RORC, SRC, XDH 4.88179
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, AKR1C3, AURKB, AXL, CA7, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP4, FLT3, IDO1, IGF1R, KDR, KIT, MET, MIF, MMP12, PIM1, PPARA, RORC, SRC, XDH 4.79159
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1C3, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, IDO1, XDH 4.79159
[BP] GO:0015701 bicarbonate transport CA12, CA14, CA4, CA7, CA9 4.79159
[BP] GO:0010035 response to inorganic substance AKR1B1, AKR1C3, AXL, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, KIT, SRC 4.7337
[BP] GO:0032787 None AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, IDO1, MIF, PPARA 4.59385
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 4.57094
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, AKR1C3, CNR1, CYP1A1, FLT3, KIT, PPARA, RORC, SRC 4.55213
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1C3, ALOX5, ALPL, AOX1, AURKB, AXL, CA12, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, FABP4, FLT3, HSD17B1, IDO1, IGF1R, KDR, KIT, MET, MIF, PIM1, PPARA, RORC, SRC, XDH 4.55213
[BP] GO:0001676 long-chain fatty acid metabolic process AKR1C3, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 4.55171
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CNR1, CNR2, CYP19A1, ESR1, FABP4, IDO1, KDR, MET, MIF, MMP12, PPARA 4.54213
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AKR1C3, AURKB, AXL, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, IGF1R, KDR, KIT, MET, MIF, MMP12, SRC, XDH 4.53319
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AKR1C3, AURKB, AXL, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, IGF1R, KDR, KIT, MET, MIF, MMP12, SRC, XDH 4.4431
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, AKR1C3, AURKB, AXL, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, FABP4, FLT3, IDO1, IGF1R, KDR, KIT, MET, MIF, MMP12, PPARA, SRC, XDH 4.42493
[BP] GO:0009719 response to endogenous stimulus AKR1B1, AKR1C3, ALPL, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FLT3, IGF1R, KIT, PPARA, SRC 4.41808
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, AKR1C3, CNR1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1 4.41808
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1C3, ALOX5, ALPL, AXL, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, FABP4, IDO1, IGF1R, KIT, MET, MMP12, PIM1, PPARA, RORC, SRC 4.39544
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, AKR1C3, ALPL, AURKB, AXL, CA9, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FLT3, KDR, KIT, MET, MIF, PIM1, PPARA, RORC, SRC 4.39163
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, IDO1, SRC 4.38935
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, KIT, MET, SRC 4.35879
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, KIT, MET, SRC 4.31675
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1B1, KDR, SRC 4.28103
[BP] GO:0071310 cellular response to organic substance AKR1B1, AKR1C3, ALPL, AXL, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, KIT, RORC, SRC 4.27558
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AKR1C3, AXL, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, KDR, KIT, MET, MIF, MMP12, SRC, XDH 4.26697
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AKR1C3, AXL, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, KDR, KIT, MET, MIF, MMP12, SRC, XDH 4.24675
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, IDO1, SRC 4.20539
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AKR1C3, AXL, CNR1, CSNK2A1, CYP1B1, ESRRA, FABP4, FLT3, IDO1, KDR, KIT, MET, MIF, MMP12, SRC, XDH 4.1251
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALPL, AURKB, AXL, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP4, FLT3, IDO1, IGF1R, KDR, KIT, MIF, MMP12, PPARA, RORC, SRC 4.08454
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 4.076
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 4.076
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, AKR1C3, ALPL, AXL, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, KIT, RORC, SRC 4.076
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA7, CNR1, CNR2 3.78012
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AKR1C3, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, IGF1R, KDR, KIT, MET, MIF, SRC, XDH 3.73355
[BP] GO:0071407 cellular response to organic cyclic compound AKR1C3, ALPL, CYP1A1, CYP1B1, ESR1, FLT3, RORC, SRC 3.69889
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, FABP4, IGF1R, MET, PIM1, PPARA, SRC 3.69889
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1C3, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP4, IDO1, MMP12, SRC, XDH 3.69889
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AKR1C3, AXL, CYP1B1, FLT3, KDR, KIT, MET, MIF, SRC, XDH 3.68923
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, AKR1C3, ALPL, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FLT3, KDR, KIT, PIM1, PPARA, RORC, SRC 3.65463
[BP] GO:0006730 one-carbon metabolic process CA12, CA4, CA7, CA9 3.60751
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.60107
[BP] GO:0008283 cell proliferation ACHE, AURKB, CYP1A1, ESR1, FLT3, KIT, MET, MIF, PIM1, SRC 3.5789
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 3.55605
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, XDH 3.52856
[BP] GO:0080134 regulation of response to stress ADORA1, CNR1, CNR2, CYP19A1, ESR1, FABP4, IDO1, IGF1R, MET, MIF, MMP12, PPARA, SRC, XDH 3.42875
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, IDO1, IGF1R, KDR, MIF, PIM1, SRC 3.42875
[BP] GO:0050727 regulation of inflammatory response ADORA1, CNR1, CNR2, CYP19A1, ESR1, FABP4, IDO1, PPARA 3.42875
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1C3, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, IDO1 3.42658
[BP] GO:0019752 carboxylic acid metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, IDO1, MIF, PIM1, PPARA 3.41975
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AKR1C3, CSNK2A1, ESR1, FLT3, IGF1R, KDR, KIT, MIF, MMP12, PIM1 3.30123
[BP] GO:0002683 negative regulation of immune system process ADORA1, AXL, CNR1, CNR2, CYP19A1, IDO1, MIF, MMP12 3.30123
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, ESR1, KIT, PPARA, RORC, SRC 3.28642
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AKR1C3, AXL, CSNK2A1, CYP1B1, FLT3, KDR, KIT, MET, MIF, MMP12, SRC, XDH 3.28249
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1C3, ALOX5, ALPL, AOX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, FABP4, FLT3, HSD17B1, IDO1, IGF1R, KDR, KIT, MET, MIF, MMP12, PIM1, PPARA, RORC, SRC, XDH 3.20297
[BP] GO:2000107 negative regulation of leukocyte apoptotic process AURKB, AXL, IDO1, MIF 3.19924
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 3.18645
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AKR1C3, AXL, CYP1B1, SRC 3.14844
[BP] GO:0009115 None AOX1, XDH 3.08094
[BP] GO:0051716 cellular response to stimulus AKR1B1, AKR1C3, ALPL, AURKB, AXL, CA9, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, KIT, MIF, RORC, SRC 3.06217
[BP] GO:0009892 negative regulation of metabolic process ADORA1, AKR1C3, AURKB, CNR1, CNR2, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, IGF1R, KDR, MET, MIF, MMP12, PPARA, RORC, SRC, XDH 3.05699
[BP] GO:0043436 oxoacid metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, IDO1, MIF, PIM1, PPARA 3.05699
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, RORC 3.05699
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 3.03138
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, CYP19A1, CYP1B1, IGF1R, KDR, KIT, MET, MIF, SRC 3.02298
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 3.02298
[BP] GO:0006082 organic acid metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, IDO1, MIF, PIM1, PPARA 2.99971
[BP] GO:0031347 regulation of defense response ADORA1, CNR1, CNR2, CYP19A1, ESR1, FABP4, IDO1, MMP12, PPARA, SRC 2.96395
[BP] GO:0051896 regulation of protein kinase B signaling AKR1C3, AXL, KIT, MET, SRC, XDH 2.96395
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1C3, ALOX5, ALPL, AOX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, FABP4, FLT3, HSD17B1, IDO1, IGF1R, KDR, KIT, MET, MIF, MMP12, PIM1, PPARA, RORC, SRC, XDH 2.8434
[BP] GO:0042446 hormone biosynthetic process AKR1B1, AKR1C3, CYP19A1, HSD17B1 2.81315
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, CYP19A1, CYP1B1, IGF1R, KDR, KIT, MET, MIF, SRC 2.81315
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, CNR1, CNR2, CYP19A1, ESR1, ESR2, IGF1R, MET, MIF, MMP12, PPARA, SRC, XDH 2.70449
[BP] GO:0046110 None AOX1, XDH 2.67382
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.6545
[BP] GO:0042180 None AKR1B1, AKR1C3, CYP19A1, IDO1 2.6247
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, AKR1C3, AURKB, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP4, FLT3, IGF1R, KDR, KIT, MET, MIF, MMP12, PIM1, PPARA, RORC, SRC, XDH 2.61823
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.60302
[BP] GO:0044248 cellular catabolic process ACHE, AKR1C3, AOX1, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP4, IDO1, SRC, XDH 2.5767
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1 2.55488
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.55488
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, CYP19A1, CYP1B1, IGF1R, KDR, KIT, MET, MIF, SRC 2.55488
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, CYP19A1, CYP1B1, IGF1R, KDR, KIT, MET, MIF, SRC 2.54507
[BP] GO:1901575 None ACHE, ADORA1, AKR1C3, AOX1, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP4, IDO1, XDH 2.53917
[BP] GO:0051897 positive regulation of protein kinase B signaling AKR1C3, AXL, KIT, MET, SRC 2.53917
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, AXL, CA7, CNR1, CSNK2A1, CYP19A1, CYP1B1, IGF1R, KDR, KIT, MET, MIF, MMP12, PPARA, SRC 2.50578
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, AURKB, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FLT3, IGF1R, KDR, KIT, MET, MIF, MMP12, PPARA, RORC, SRC, XDH 2.50447
[BP] GO:0046427 positive regulation of JAK-STAT cascade AKR1B1, CYP1B1, FLT3, KIT 2.46944
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, AKR1C3, CSNK2A1, CYP19A1, CYP1A1, HSD17B1, MIF 2.46944
[BP] GO:0048608 reproductive structure development AKR1C3, AXL, CYP19A1, ESR1, KIT, SRC 2.44125
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1C3, CYP19A1, CYP1A2, CYP1B1, FABP4 2.44125
[BP] GO:0022414 reproductive process AKR1B1, AKR1C3, ALPL, AXL, CNR1, CYP19A1, CYP1A1, ESR1, ESRRB, IDO1, KIT, SRC 2.44125
[BP] GO:1904894 positive regulation of STAT cascade AKR1B1, CYP1B1, FLT3, KIT 2.44076
[BP] GO:0042493 response to drug AKR1B1, AXL, CA9, CNR1, CNR2, CYP1A1, CYP1B1, KDR, SRC 2.44076
[BP] GO:0006145 None AOX1, XDH 2.44076
[BP] GO:0038171 None CNR1, CNR2 2.44076
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.44076
[BP] GO:0009893 positive regulation of metabolic process ADORA1, AKR1C3, AURKB, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FLT3, IGF1R, KDR, KIT, MET, MIF, MMP12, PPARA, RORC, SRC, XDH 2.43723
[BP] GO:0006468 protein phosphorylation AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC 2.41453
[BP] GO:2000106 regulation of leukocyte apoptotic process AURKB, AXL, IDO1, MIF 2.3939
[BP] GO:0032103 positive regulation of response to external stimulus CNR1, FABP4, IDO1, KDR, MET, MIF 2.38757
[BP] GO:0070229 negative regulation of lymphocyte apoptotic process AURKB, IDO1, MIF 2.35785
[BP] GO:0031348 negative regulation of defense response ADORA1, CNR2, CYP19A1, MMP12, PPARA 2.34215
[BP] GO:0009605 response to external stimulus ADORA1, AKR1C3, ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, IDO1, KIT, MMP12, SRC 2.33689
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, AKR1C3, AURKB, ESR1, ESR2, ESRRA, ESRRB, FLT3, IGF1R, KDR, KIT, MET, MIF, MMP12, PPARA, RORC, SRC, XDH 2.3286
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, ESR2, FABP4, FLT3, IGF1R, KIT, MET, MIF, PIM1, PPARA, SRC, XDH 2.3286
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, FLT3, KIT, MIF, SRC 2.32757
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC 2.32708
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AKR1C3, AXL, CYP1B1, SRC 2.32032
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, AURKB, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FLT3, IGF1R, KDR, KIT, MET, MIF, MMP12, PPARA, RORC, SRC, XDH 2.30828
[BP] GO:0003006 developmental process involved in reproduction AKR1C3, ALPL, AXL, CYP19A1, ESR1, ESRRB, KIT, SRC 2.27434
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, AKR1C3, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, ESR2, FLT3, IGF1R, KDR, KIT, MET, MIF, MMP12, SRC, XDH 2.26474
[BP] GO:0044283 None AKR1B1, AKR1C3, ALOX5, CYP19A1, CYP1A1, IDO1, MIF 2.26474
[BP] GO:0061370 testosterone biosynthetic process AKR1C3, CYP19A1 2.26454
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.26454
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA7, CNR1, CNR2, KIT 2.24343
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA7, CNR1, CNR2, KIT 2.24343
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, KIT, SRC 2.23244
[BP] GO:0010907 None ESRRB, PPARA, SRC 2.23244
[BP] GO:1901361 None AOX1, CYP19A1, CYP1A1, CYP1A2, CYP2A6, IDO1, XDH 2.1949
[BP] GO:0043207 response to external biotic stimulus ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, IDO1, MMP12, SRC 2.19002
[BP] GO:0010906 None ESRRB, PPARA, RORC, SRC 2.18464
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AKR1C3, AXL, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FLT3, IGF1R, KDR, KIT, MET, MIF, PIM1, PPARA, RORC, SRC 2.17492
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AKR1C3, AXL, CYP1B1, SRC 2.13946
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, AXL, CNR1, CYP1B1, ESR1, ESRRA, ESRRB, IDO1, KDR, KIT, MET, MIF, MMP12, PIM1, SRC, XDH 2.13946
[BP] GO:0010760 negative regulation of macrophage chemotaxis CYP19A1, MIF 2.12572
[BP] GO:0046113 None AOX1, XDH 2.12572
[BP] GO:0032229 None ADORA1, CNR2 2.12572
[BP] GO:0060135 None AKR1B1, CNR1, ESR1 2.10702
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA7, CNR1, KDR, MIF, SRC 2.09686
[BP] GO:0048806 genitalia development AXL, CYP19A1, ESR1 2.07811
[BP] GO:0002686 None ADORA1, CYP19A1, MIF 2.07811
[BP] GO:0009607 response to biotic stimulus ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, IDO1, MMP12, SRC 2.07564
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, CNR2, ESR1, ESR2, IGF1R, MET, MIF, MMP12, SRC, XDH 2.05621
[BP] GO:0002682 regulation of immune system process ADORA1, AXL, CNR1, CNR2, CYP19A1, ESR1, ESRRA, IDO1, KIT, MIF, MMP12, SRC 2.04809
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, CNR2, ESR1, ESR2, IGF1R, MET, MIF, MMP12, SRC, XDH 2.04809
[BP] GO:0051240 positive regulation of multicellular organismal process AXL, CNR1, CYP1B1, ESRRB, IDO1, KDR, KIT, MET, MIF, MMP12, PIM1, SRC 2.03597
[BP] GO:0006721 terpenoid metabolic process AKR1C3, CYP1A1, CYP1A2, CYP1B1 2.03597
[BP] GO:0006091 generation of precursor metabolites and energy AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, XDH 2.03392
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, CYP1B1, SRC 2.02616
[BP] GO:0008406 gonad development AKR1C3, CYP19A1, ESR1, KIT 2.02616
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, FLT3, IGF1R, KIT, MIF, SRC 2.01593
[BP] GO:0051001 None CNR1, CNR2 2.01593
[BP] GO:0031324 negative regulation of cellular metabolic process AKR1C3, AURKB, CNR1, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, IGF1R, MET, MIF, MMP12, PPARA, RORC, SRC, XDH 2.00234
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALPL, AXL, CA12, CA14, CA4, CA9, CNR1, CNR2, CSNK2A1, ESR1, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC 1.35825
[CC] GO:0042629 None AKR1B1, KIT 1.21576
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, AXL, CA4, CNR1, CNR2, FLT3, IGF1R, KDR, MET 1.18633
[CC] GO:0044228 host cell surface AXL 1.03795
[CC] GO:0044464 cell part ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALOX5, ALPL, AOX1, AURKB, AXL, CA12, CA14, CA4, CA7, CA9, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, FABP4, FLT3, HSD17B1, IDO1, IGF1R, KDR, KIT, MET, MIF, MMP12, PIM1, PPARA, RORC, SRC, XDH 0.935402
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, CA12, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, MMP12, PIM1, PPARA, RORC, XDH 10.609
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AOX1, AURKB, AXL, CA12, CA14, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, FABP4, FLT3, HSD17B1, IDO1, IGF1R, KDR, KIT, MET, MMP12, PIM1, PPARA, RORC, SRC, XDH 7.69868
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 7.15598
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, XDH 6.89337
[MF] GO:0004089 carbonate dehydratase activity CA12, CA14, CA4, CA7, CA9 6.70448
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, IDO1, SRC 6.28685
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1C3, ALOX5, ALPL, AOX1, AURKB, AXL, CA12, CA14, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FLT3, HSD17B1, IDO1, IGF1R, KDR, KIT, MET, MIF, MMP12, PIM1, SRC, XDH 6.07973
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, IDO1, SRC 6.07973
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.94209
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.94209
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 5.86792
[MF] GO:0004497 monooxygenase activity AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.86257
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.59898
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1C3, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, IDO1, XDH 5.59898
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 5.53016
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, IDO1, SRC, XDH 5.44321
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, AURKB, CA12, CA14, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, IDO1, KIT, MMP12, PIM1, PPARA, RORC, XDH 5.33849
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, FLT3, IGF1R, KDR, KIT, MET, PIM1, PPARA, SRC 5.33115
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, FLT3, IGF1R, KDR, KIT, MET, PPARA, RORC 5.12745
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 5.05895
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, AURKB, CA12, CA14, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, IDO1, KIT, MMP12, PIM1, PPARA, RORC, XDH 4.91595
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD17B1, RORC 4.86788
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 4.76541
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 4.75563
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, FLT3, IGF1R, KDR, KIT, MET, PPARA, RORC 4.53319
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, XDH 4.40948
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET, SRC 4.40948
[MF] GO:0016836 hydro-lyase activity CA12, CA14, CA4, CA7, CA9 4.40948
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, FLT3, IGF1R, KDR, KIT, MET, PPARA, RORC 4.39544
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, FLT3, IGF1R, KDR, KIT, MET, PPARA, RORC 4.076
[MF] GO:0016835 carbon-oxygen lyase activity CA12, CA14, CA4, CA7, CA9 3.81936
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6 3.6931
[MF] GO:0008270 zinc ion binding CA12, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP12, PPARA, RORC 3.61911
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC 3.58085
[MF] GO:0016903 None AKR1B1, AKR1C3, AOX1, XDH 3.30123
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 3.08094
[MF] GO:0008389 None CYP2A13, CYP2A6 3.08094
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC 2.97278
[MF] GO:1901363 heterocyclic compound binding ADORA1, AOX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD17B1, IDO1, IGF1R, KDR, KIT, MET, MMP12, PIM1, PPARA, RORC, SRC, XDH 2.9442
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, MMP12, PIM1, PPARA, SRC 2.92264
[MF] GO:0097159 organic cyclic compound binding ADORA1, AOX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD17B1, IDO1, IGF1R, KDR, KIT, MET, MMP12, PIM1, PPARA, RORC, SRC, XDH 2.87799
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1C3, AOX1, HSD17B1, XDH 2.72727
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC 2.67382
[MF] GO:0004949 None CNR1, CNR2 2.67382
[MF] GO:0008289 lipid binding AXL, ESR1, ESR2, ESRRA, ESRRB, FABP4, HSD17B1, PPARA, RORC 2.67205
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.44076
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.26454
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ESRRB, FLT3, IGF1R, KDR, MMP12, PPARA, SRC 2.23978
[MF] GO:0016829 lyase activity CA12, CA14, CA4, CA7, CA9 2.23244
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC 2.19002
[MF] GO:0043546 None AOX1, XDH 2.12572
[MF] GO:0005021 vascular endothelial growth factor-activated receptor activity FLT3, KDR 2.01593
[MF] GO:0004032 None AKR1B1, AKR1C3 2.01593
[MF] GO:0001609 None ADORA1, ADORA3 2.01593


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, CYP1A1, AKR1C3, CYP1B1, CYP19A1, IGF1R 8.8928
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, CYP1A2, CYP1A1, AKR1C3, CYP1B1, CYP19A1 7.0358
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1, IDO1 6.2168
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA4, CA7, CA9, CA14 7.9266
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 5.0571
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, CNR1, KIT, KDR, MET, IGF1R 4.1174
Metabolic pathways_Homo sapiens_hsa01100 CYP2A6, ALOX5, HSD17B1, CYP1A2, CYP1A1, AKR1C3, AOX1, ALPL, AKR1B1, CYP19A1, XDH, IDO1 4.0335
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 4.871
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1 3.9097
Adherens junction_Homo sapiens_hsa04520 CSNK2A1, SRC, MET, IGF1R 3.727
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, KDR, MET, ESR1, IGF1R 3.1876
Endocytosis_Homo sapiens_hsa04144 SRC, KIT, KDR, MET, IGF1R 2.7272
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, KIT, PIM1 2.7151
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, KIT, MET 2.5375
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.4999
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, IGF1R 2.26
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2, AOX1 2.5278
Ras signaling pathway_Homo sapiens_hsa04014 KIT, KDR, MET, IGF1R 2.1185
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, ESR1, ESR2 2.1458
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET 1.8993
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.7003
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CNR2, CNR1, ADORA3, ADORA1 1.8649
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 KIT, KDR, MET, IGF1R 1.5814
Pathways in cancer_Homo sapiens_hsa05200 FLT3, KIT, MET, IGF1R 1.4742
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MET, IGF1R 1.5659
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.5714
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.5331
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.4742
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.4742
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, AKR1C3 1.5331
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.7033
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MET 1.1225
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, MIF 1.8993
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.4107
PPAR signaling pathway_Homo sapiens_hsa03320 FABP4, PPARA 1.4742
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 1.336
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 1.121
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 1.1188
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, AOX1 0.9535
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 1.0272
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 1.0339
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.9296
cAMP signaling pathway_Homo sapiens_hsa04024 ADORA1, PPARA 0.8489
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.5989
Prostate cancer_Homo sapiens_hsa05215 IGF1R 0.5989
GnRH signaling pathway_Homo sapiens_hsa04912 SRC 0.5989
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5989
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIM1 0.5989
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5989
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 IGF1R 0.5989
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5989
Gap junction_Homo sapiens_hsa04540 SRC 0.5989
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5989
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5989
Melanogenesis_Homo sapiens_hsa04916 KIT 0.5989
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.6635
Glioma_Homo sapiens_hsa05214 IGF1R 0.6635
Peroxisome_Homo sapiens_hsa04146 XDH 0.5989
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.5792
Insulin resistance_Homo sapiens_hsa04931 PPARA 0.5797
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5989
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.5989
Platelet activation_Homo sapiens_hsa04611 SRC 0.5596
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5989
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6635
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1 0.4429
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.5965
Purine metabolism_Homo sapiens_hsa00230 XDH 0.4751
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.431
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.5596
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.4418
Hepatitis B_Homo sapiens_hsa05161 SRC 0.53
Measles_Homo sapiens_hsa05162 CSNK2A1 0.5432
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1 0.5989
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.5315
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.547
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.4658
Phospholipase D signaling pathway_Homo sapiens_hsa04072 KIT 0.5308
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.522
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6635
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.564
Tuberculosis_Homo sapiens_hsa05152 SRC 0.4751
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.5596
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6463
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5 0.5792
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.547
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.5096
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.6635
Axon guidance_Homo sapiens_hsa04360 MET 0.5552
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.4658
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B1 0.6635
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.6635
Shigellosis_Homo sapiens_hsa05131 SRC 0.6635
Malaria_Homo sapiens_hsa05144 MET 0.7291
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.731
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.73
Bladder cancer_Homo sapiens_hsa05219 SRC 0.7799
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.8297
Galactose metabolism_Homo sapiens_hsa00052 AKR1B1 0.869
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.869
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B1 0.8508
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B1 0.8262
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.869
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.869
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA4 0.9355
Phenylalanine metabolism_Homo sapiens_hsa00360 MIF 1.0339
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.096
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.4023


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)