TCM Prescription: Intestine Lubricating Pills



Prescription Description
Prescription IDTCMF1813
Pinyin NameRun Chang Wan
Chinese Name润肠丸
English NameIntestine Lubricating Pills
Function Description便秘
IndicationsConstipation disorder
Disease ICD-11 Category SA57 [Constipation disorder (TM1), 便秘 (TM1) ];
Human Tissues Associated with IndicationLarge Intestine
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH1665 Notopterygium incisum 羌活 TCMH1665 JF755946
TCMH363 Rheum officinale 大黄 TCMH363 ITSAJ4685-14
TCMH2073 Prunus persica 桃仁 TCMH2073 ITSAN1047-14
TCMH1421 Fructus cannabis 麻子仁 TCMH1421
TCMH583 Apis cerana 蜂蜜 TCMH583 AGIRI284-17
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT242 HRH3 Histamine H3 receptor GPCR Q9Y5N1
TCMT245 HRH2 Histamine H2 receptor GPCR P25021
TCMT246 HRH4 Histamine H4 receptor GPCR Q9H3N8
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT645 HTR1E Serotonin 1e (5-HT1e) receptor GPCR P28566
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT689 TGM2 Protein-glutamine gamma-glutamyltransferase Transferase P21980
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT815 HTR1D Serotonin 1d (5-HT1d) receptor GPCR P28221
TCMT816 HTR1B Serotonin 1b (5-HT1b) receptor GPCR P28222
TCMT817 HTR4 Serotonin 4 (5-HT4) receptor GPCR Q13639
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1182 Streptococcus sanguinis
TCMT1183 Candida albicans SC5314
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1408 Colletotrichum gloeosporioides
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1444 Fusarium oxysporum
TCMT1448 Enterobacter aerogenes
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0007210 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 18.4917
[BP] GO:0098664 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 18.4917
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 13.0877
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.9934
[BP] GO:0007187 None ADORA1, CHRM2, CNR1, CNR2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR4, HTR5A, HTR6, HTR7 11.2078
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 10.3677
[BP] GO:0097756 None ADORA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 9.73257
[BP] GO:0044281 small molecule metabolic process AKR1B1, ALOX15, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FUT7, HTR2B, HTR2C, PIK3CA, PPARA, PTGS1, PTGS2 9.70254
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, CA2, CHRM2, CNR1, CNR2, ESR1, HCAR2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PIK3CA, PIK3CB 9.53266
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, ALOX15, BCL2, CA12, CA2, CA7, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FABP4, HCAR2, HRH3, HRH4, HSD11B1, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR4, HTR7, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 9.3591
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, ALOX15, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD11B2, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 9.1536
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 8.1391
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 8.04996
[BP] GO:0006690 icosanoid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 7.90935
[BP] GO:0007193 None ADORA1, CHRM2, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 7.45784
[BP] GO:0007198 None HTR1A, HTR1B, HTR5A, HTR7 7.35172
[BP] GO:0019748 secondary metabolic process AKR1B1, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 7.11817
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, ESR1, HCAR2, HSD11B1, HSD11B2, HTR1A, HTR2A, HTR2C 7.08095
[BP] GO:0042310 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7 6.9221
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, CNR1, CNR2, HTR1B 6.65607
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 6.47521
[BP] GO:0007188 None ADORA1, CHRM2, CNR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 6.46981
[BP] GO:0050795 None ADORA1, CNR1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B 6.46981
[BP] GO:0006631 fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PTGS1, PTGS2 6.42088
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, ALPL, BCL2, CA2, CA9, CNR1, CNR2, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, HSD11B2, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, MMP2, MMP9, PIK3CA, PPARA, PTGS2 6.40364
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, BCL2, CA9, CNR1, CNR2, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, HSD11B2, HTR1B, HTR5A, MMP2, MMP9, PIK3CA, PPARA, PTGS2 6.17891
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 6.04132
[BP] GO:0097746 None ADORA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 5.98488
[BP] GO:0035296 None ADORA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 5.98488
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.87731
[BP] GO:0050880 None ADORA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 5.7931
[BP] GO:0035150 None ADORA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 5.7748
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, CNR1, HRH3, HTR1B, HTR2A, MMP9, PTGS2 5.6107
[BP] GO:0071073 None FABP3, HTR2A, HTR2B, HTR2C 5.56401
[BP] GO:0044255 cellular lipid metabolic process ACHE, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, FUT7, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 5.5307
[BP] GO:0033993 response to lipid ALPL, BCL2, CA2, CA9, CNR1, CNR2, CYP1A1, CYP1A2, ESR1, FABP3, HSD11B2, HTR1B, HTR5A, PTGS2 5.38135
[BP] GO:0099536 None CHRM2, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 5.37739
[BP] GO:0099537 None CHRM2, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 5.37739
[BP] GO:0003018 None ADORA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 5.33993
[BP] GO:0042493 response to drug AKR1B1, BCL2, CA9, CNR1, CNR2, CYP1A1, CYP1B1, FABP3, HSD11B2, HTR1B, HTR2A, HTR2B, HTR2C, PTGS2 5.30716
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, CNR2, HTR1B, HTR2A, PTGS2 5.0468
[BP] GO:0008202 steroid metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, HSD11B1, HSD11B2 4.97549
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CYP1A2, ESR1, FABP3, HSD11B2, HTR1B, HTR5A, PPARA, PTGS2 4.95646
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 4.928
[BP] GO:0048878 chemical homeostasis AKR1B1, BCL2, CA12, CA2, CA7, CNR1, ESR1, FABP3, FABP4, HRH4, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB 4.84381
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2 4.788
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, BCL2, CA2, CA6, CA9, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, HRH4, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 4.73049
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, BCL2, CA2, CA9, CNR1, CNR2, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, HSD11B2, HTR1B, HTR5A, MMP2, PIK3CA, PPARA, PTGS2 4.72005
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CNR1, CYP1A1, FABP3, HCAR2, HTR2A, HTR2B, HTR2C, PPARA, PTGS2 4.66651
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.61669
[BP] GO:0032844 regulation of homeostatic process ADORA1, BCL2, CA2, CA7, CNR1, HCAR2, HTR2A, HTR2B, HTR2C, PIK3CB, PTGS2 4.59857
[BP] GO:0032787 None ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PTGS1, PTGS2 4.56699
[BP] GO:0071071 None FABP3, HTR2A, HTR2B, HTR2C 4.54602
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CA9, CNR1, CYP1A1, CYP1A2, CYP1B1, ESR1, HSD11B2, HTR1B, HTR5A, PTGS2 4.53787
[BP] GO:0003013 None ADORA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 4.49642
[BP] GO:0007268 None CHRM2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 4.4502
[BP] GO:0098916 None CHRM2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 4.4502
[BP] GO:0055114 oxidation-reduction process AKR1B1, ALOX15, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B1, HSD11B2, NQO2, PTGS1, PTGS2 4.35723
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, CNR1, CNR2, HTR1B, HTR2A, PTGS2 4.35723
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, CNR1, CNR2, HTR1B, HTR2A, PTGS2 4.35723
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, ALOX15, ALPL, BCL2, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, ESR1, FABP4, HRH3, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR7, MMP1, MMP2, MMP9, PIK3CA, PPARA, PTGS2 4.33648
[BP] GO:0010513 None HTR2A, HTR2B, HTR2C 4.28734
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CYP19A1, CYP1A1, HSD11B1, HSD11B2, PIK3CA, PIK3CB, PTGS1, PTGS2 4.01869
[BP] GO:0032229 None ADORA1, CNR2, HTR1B 4.01327
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, BCL2, CA2, CA9, CYP1A2, ESR1, FABP3, HSD11B2, HTR1B, HTR5A, MMP2, PPARA, PTGS2 3.91954
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, BCL2, CA2, CA7, CNR1, CYP19A1, HCAR2, HRH3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MMP9, PIK3CB, PPARA, PTGS2 3.91954
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, MMP9, PTGS2 3.81854
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, CNR1, HTR1B, HTR2A, PTGS2 3.81168
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.80362
[BP] GO:0014062 None HRH3, HTR1A, HTR1B 3.80362
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.80362
[BP] GO:0010511 None HTR2A, HTR2B, HTR2C 3.80362
[BP] GO:0007154 None ADORA1, BCL2, CHRM2, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PTGS2 3.75277
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, NQO2, PTGS1 3.73969
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, BCL2, CA12, CA2, CA7, CNR1, ESR1, FABP3, FABP4, HRH4, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB 3.72862
[BP] GO:0090066 None ADORA1, ALOX15, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 3.69959
[BP] GO:0046889 None FABP3, HTR2A, HTR2B, HTR2C, PTGS2 3.67437
[BP] GO:0043269 regulation of ion transport ADORA1, BCL2, CA2, CA7, CNR1, HRH3, HTR1A, HTR1B, HTR2A, MMP9, PTGS2 3.67437
[BP] GO:0003008 None ADORA1, AKR1B1, BCL2, CNR1, CNR2, CYP1B1, HRH3, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PIK3CA, PTGS2 3.63867
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, HTR2A, HTR2B, HTR2C, PPARA, PTGS2 3.57215
[BP] GO:0007267 None ADORA1, CHRM2, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 3.56203
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling HTR2A, HTR2B, PIK3CA, PIK3CB 3.47416
[BP] GO:1900543 None HRH3, HRH4, HTR1B, HTR1E, PPARA 3.46859
[BP] GO:0045980 None HRH3, HRH4, HTR1B, HTR1E, PPARA 3.4418
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, HTR1B, HTR1D 3.42918
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, HTR2A, HTR2B, HTR2C 3.41356
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, BCL2, CA2, CA7, CYP19A1, CYP1B1, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, MMP9, PIK3CA, PIK3CB, PTGS2 3.37796
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, BCL2, CA2, CA7, CYP19A1, CYP1B1, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, MMP9, PIK3CA, PIK3CB, PTGS2 3.35616
[BP] GO:0051952 None ADORA1, CNR1, HRH3, HTR1B, HTR2A 3.34876
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HTR1B, MMP2, MMP9, PTGS2 3.34876
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.34644
[BP] GO:0050801 ion homeostasis BCL2, CA12, CA2, CA7, ESR1, FABP3, HRH4, HTR2A, HTR2B, HTR2C, PIK3CB 3.32774
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, HTR2A, HTR2B, HTR2C, PPARA 3.31111
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, BCL2, CA2, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, HRH4, HSD11B2, HTR1A, HTR2C, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 3.30624
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CNR1, CYP19A1, HCAR2, HRH3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C 3.25719
[BP] GO:0010038 response to metal ion ALOX15, BCL2, CA2, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 3.2439
[BP] GO:0019371 None CBR1, PTGS1, PTGS2 3.23147
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, ALOX15, CNR2, HRH4, PIK3CA, PIK3CB, PTGS1, PTGS2 3.19877
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 3.17651
[BP] GO:0023052 None ADORA1, CHRM2, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 3.17651
[BP] GO:0008217 None ADORA1, CNR1, HSD11B2, PPARA, PTGS1, PTGS2 3.1642
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, BCL2, FABP3, FABP4, HRH3, HRH4, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2 3.11202
[BP] GO:0007200 None CHRM2, ESR1, HTR2A, HTR2B, HTR2C 3.10233
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, BCL2, FABP3, FABP4, HRH3, HRH4, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2 3.07112
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, BCL2, CA1, CA2, CHRM2, CNR1, CNR2, CYP1B1, ESR1, HCAR2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, MMP2, MMP9, PIK3CA, PIK3CB, PPARA 3.03109
[BP] GO:0051046 None ACHE, ADORA1, CNR1, CYP19A1, HCAR2, HRH3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C 2.98914
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX15, BCL2, CA2, CA7, CNR1, CYP19A1, CYP1B1, HCAR2, HRH3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MMP9, PIK3CB, PPARA, PTGS2 2.98914
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, HTR2A, HTR2B, HTR2C 2.98159
[BP] GO:0051967 None ADORA1, HTR1B, HTR2A 2.93843
[BP] GO:0007208 None HTR2A, HTR2C 2.93843
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, BCL2, CA2, CA7, CNR1, CNR2, CYP19A1, CYP1B1, ESR1, HCAR2, HRH4, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, MMP9, PIK3CA, PIK3CB, PTGS2 2.93705
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2 2.88229
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.85555
[BP] GO:0050433 None CNR1, HRH3, HTR1B, HTR2A 2.85555
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, BCL2, CA2, CA7, CNR1, CNR2, CYP19A1, CYP1B1, ESR1, HCAR2, HRH4, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, MMP9, PIK3CA, PIK3CB, PTGS2 2.85555
[BP] GO:0009895 negative regulation of catabolic process ADORA1, BCL2, CNR1, HCAR2, HTR2B, PIK3CA, PPARA 2.85255
[BP] GO:0046883 regulation of hormone secretion ADORA1, CNR1, CYP19A1, HCAR2, HTR1A, HTR2A, HTR2C 2.85255
[BP] GO:0030815 None HRH3, HRH4, HTR1B, HTR1E 2.82991
[BP] GO:0006939 None HTR1D, HTR2A, HTR2B, HTR7 2.82991
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2 2.81793
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, PPARA 2.77502
[BP] GO:0030800 None HRH3, HRH4, HTR1B, HTR1E 2.7664
[BP] GO:0098771 inorganic ion homeostasis BCL2, CA12, CA2, CA7, ESR1, HRH4, HTR2A, HTR2B, HTR2C, PIK3CB 2.74639
[BP] GO:0050727 regulation of inflammatory response ADORA1, CNR1, CNR2, CYP19A1, ESR1, FABP4, PPARA, PTGS2 2.71701
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1 2.71701
[BP] GO:0050994 None ADORA1, CNR1, HCAR2, PPARA 2.71078
[BP] GO:0055082 cellular chemical homeostasis BCL2, CA2, CA7, ESR1, HRH4, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB 2.6954
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, BCL2, CYP1B1, HTR2A, HTR2B, HTR2C, HTR6, PIK3CA, PIK3CB, PTGS2 2.62702
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, MMP2, MMP9 2.61314
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2 2.60448
[BP] GO:0007610 None BCL2, CNR1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, PPARA, PTGS2 2.55438
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.52938
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, BCL2, CA2, CYP1A1, HSD11B2, HTR1B, HTR2A, HTR2B, MMP2, PPARA, PTGS2 2.52938
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2 2.46563
[BP] GO:0048015 phosphatidylinositol-mediated signaling HTR2A, HTR2B, PIK3CA, PIK3CB 2.46563
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PTGS1, PTGS2 2.44787
[BP] GO:0030003 cellular cation homeostasis BCL2, CA2, CA7, ESR1, HRH4, HTR2A, HTR2B, HTR2C, PIK3CB 2.40962
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation HTR1B, MMP2, MMP9 2.407
[BP] GO:0050995 None ADORA1, CNR1, HCAR2 2.407
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, HTR1B, MMP2, MMP9, PTGS2 2.40623
[BP] GO:0048017 inositol lipid-mediated signaling HTR2A, HTR2B, PIK3CA, PIK3CB 2.39674
[BP] GO:0051953 None ADORA1, CNR1, HRH3 2.35624
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.35624
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, HSD11B2, HTR1B, PTGS2 2.34859
[BP] GO:0006873 cellular ion homeostasis BCL2, CA2, CA7, ESR1, HRH4, HTR2A, HTR2B, HTR2C, PIK3CB 2.34521
[BP] GO:0032098 None HTR2C, HTR4, PPARA 2.30801
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.30801
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, BCL2, CYP1B1, ESR1, FABP3, HTR1A, HTR1B, HTR2A, HTR2B, MMP2, MMP9, PTGS1, PTGS2 2.3016
[BP] GO:0032846 positive regulation of homeostatic process CA2, CA7, CNR1, HCAR2, PIK3CB, PTGS2 2.28341
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.28053
[BP] GO:0038171 None CNR1, CNR2 2.28053
[BP] GO:0014063 None HRH3, HTR1B 2.28053
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.28053
[BP] GO:0014827 None HTR1D, HTR2B 2.28053
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, HTR2A, HTR2B, HTR2C 2.2256
[BP] GO:1900542 None HRH3, HRH4, HTR1B, HTR1E, HTR2A, PPARA 2.21651
[BP] GO:0032845 None ADORA1, BCL2, HTR2A, HTR2B, HTR2C 2.20099
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, BCL2, CA2, CA9, CBR1, CHRM2, CNR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FUT7, HSD11B1, HTR2A, HTR2B, HTR5A, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2 2.18726
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, BCL2, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, HTR1B, MMP2, MMP9, PIK3CA, PTGS2 2.16939
[BP] GO:0031214 biomineral tissue development ALOX15, ALPL, PPARA, PTGS2 2.16834
[BP] GO:0006140 None HRH3, HRH4, HTR1B, HTR1E, HTR2A, PPARA 2.15594
[BP] GO:0046320 None CNR1, FABP3, PPARA 2.14023
[BP] GO:0033032 regulation of myeloid cell apoptotic process BCL2, HCAR2, PIK3CB 2.14023
[BP] GO:0014059 None CNR1, HTR1B, HTR2A 2.14023
[BP] GO:0009266 None ADORA1, HTR1B, HTR2A, HTR2B, PTGS2 2.13315
[BP] GO:0055080 cation homeostasis BCL2, CA2, CA7, ESR1, HRH4, HTR2A, HTR2B, HTR2C, PIK3CB 2.12539
[BP] GO:0043436 oxoacid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PTGS1, PTGS2 2.12478
[BP] GO:0019725 cellular homeostasis BCL2, CA2, CA7, ESR1, HRH4, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB 2.11127
[BP] GO:0006952 defense response ADORA1, ADORA3, ALOX15, BCL2, CNR2, HRH4, HTR1A, HTR2C, PIK3CA, PIK3CB, PTGS1, PTGS2 2.10885
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX15, PTGS1, PTGS2 2.1056
[BP] GO:0071502 None HTR1B, HTR2B 2.09798
[BP] GO:0014050 None ADORA1, HRH3 2.09798
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, HSD11B2, HTR1B, PTGS2 2.08197
[BP] GO:0051051 negative regulation of transport ADORA1, BCL2, CNR1, HRH3, HTR1B, HTR2A, MMP9, PTGS2 2.08197
[BP] GO:0006082 organic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PTGS1, PTGS2 2.07611
[BP] GO:0035265 organ growth BCL2, CYP19A1, ESR1 2.07611
[BP] GO:0002209 None BCL2, HTR1A, HTR2C 2.07611
[BP] GO:0001662 None BCL2, HTR1A, HTR2C 2.07611
[BP] GO:0044070 regulation of anion transport ADORA1, CA2, CA7, HRH3 2.05408
[BP] GO:0045777 None ADORA1, CNR1, HSD11B2 2.03656
[BP] GO:0019217 None CNR1, FABP3, PPARA, PTGS2 2.01705
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALOX15, ALPL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, FUT7, HCAR2, HRH3, HRH4, HSD11B1, HSD11B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PIK3CA, PIK3CB, PTGS1, PTGS2 6.42088
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX15, ALPL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, FUT7, HCAR2, HRH3, HRH4, HSD11B1, HSD11B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, MMP2, PIK3CA, PIK3CB, PTGS1, PTGS2 4.82808
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, CA4, CHRM2, CNR1, CNR2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 4.63719
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALOX15, ALPL, CA12, CA14, CA2, CA4, CA9, CHRM2, CNR1, CNR2, ESR1, HCAR2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, MMP2, PIK3CA, PIK3CB 4.49301
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, CHRM2, CNR1, CNR2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 4.22048
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ALOX15, CA2, CA4, CA9, CHRM2, CNR1, CNR2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PTGS2 3.42768
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B1, HSD11B2, PTGS1, PTGS2 2.2256
[MF] GO:0099528 None CHRM2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 21.9944
[MF] GO:0008227 None CHRM2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 19.4115
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 18.4917
[MF] GO:0004993 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 18.4917
[MF] GO:0099589 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 18.4917
[MF] GO:0043176 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 18.0111
[MF] GO:0051378 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 18.0111
[MF] GO:0030594 None CHRM2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 15.8377
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 12.3285
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 12.0991
[MF] GO:0070405 ammonium ion binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 10.8791
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.7821
[MF] GO:0046914 transition metal ion binding ALOX15, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, MMP1, MMP2, MMP9, NQO2, PPARA 10.1216
[MF] GO:0004930 None ADORA1, ADORA3, CHRM2, CNR1, CNR2, HCAR2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 8.75628
[MF] GO:0043169 cation binding ACHE, ALOX15, ALPL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, MMP1, MMP2, MMP9, NQO2, PPARA, PTGS1, PTGS2 8.10632
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, CHRM2, CNR1, CNR2, ESR1, HCAR2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PPARA 7.23984
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 7.18406
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 7.12433
[MF] GO:0004872 receptor activity ADORA1, ADORA3, CHRM2, CNR1, CNR2, ESR1, HCAR2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PPARA 6.40511
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, CHRM2, CNR1, CNR2, HCAR2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 6.32636
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, CHRM2, CNR1, CNR2, HCAR2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 6.32636
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, CHRM2, CNR1, CNR2, ESR1, HCAR2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PPARA 6.19291
[MF] GO:0043167 ion binding ACHE, ALOX15, ALPL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, FABP3, FABP4, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 6.11235
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 5.88336
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, CHRM2, CNR1, CNR2, ESR1, HCAR2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PPARA 5.75626
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 5.69128
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 5.67024
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, MMP1, MMP2, MMP9, NQO2, PPARA 5.6301
[MF] GO:0016491 oxidoreductase activity AKR1B1, ALOX15, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B1, HSD11B2, NQO2, PTGS1, PTGS2 5.3406
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 5.33993
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 4.35723
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 4.15085
[MF] GO:0005506 iron ion binding ALOX15, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 4.07442
[MF] GO:0004969 None HRH3, HRH4, HTR6 4.01327
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B2, NQO2, PTGS1, PTGS2 3.68281
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6 3.34599
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.93843
[MF] GO:0003845 None HSD11B1, HSD11B2 2.93843
[MF] GO:0008389 None CYP2A13, CYP2A6 2.93843
[MF] GO:0071886 None HTR2A, HTR2C 2.93843
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, ALOX15, ALPL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FUT7, HSD11B1, HSD11B2, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PTGS1, PTGS2 2.7341
[MF] GO:0008144 drug binding ACHE, CHRM2, CNR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, HTR1B, HTR2A, HTR2B, HTR2C, NQO2, PIK3CA, PIK3CB, PPARA 2.59618
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.52938
[MF] GO:0004949 None CNR1, CNR2 2.52938
[MF] GO:0046872 metal ion binding ALOX15, ALPL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, MMP1, MMP2, MMP9, NQO2, PPARA, PTGS1, PTGS2 2.51211


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, HTR1E, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, HTR2A, HTR5A, HTR4, HTR6, HTR7, HRH3, CNR2, CNR1, ADORA3, HRH4, ADORA1 17.7802
Serotonergic synapse_Homo sapiens_hsa04726 HTR1E, ALOX15, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, HTR2A, PTGS2, HTR5A, HTR4, PTGS1, HTR6, HTR7 17.595
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 19.5222
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, HTR6, PIK3CA, HTR1E, HTR1D, ADORA1, HTR1A, HTR1B, PIK3CB, PPARA, HTR4 11.099
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2 8.7719
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 7.5733
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, ADORA1, PIK3CB, PTGS2, PTGS1 6.7238
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, HTR6, HTR7, HTR2B, HTR2C, HTR2A, HTR5A, HTR4 6.3022
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.688
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, HTR2B, HTR2C, PIK3CB, HTR2A 4.024
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, MMP2, PIK3CB, MMP9, ESR1 4.024
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, PIK3CA, BCL2, PIK3CB 3.8542
Ovarian steroidogenesis_Homo sapiens_hsa04913 CYP1A1, CYP1B1, PTGS2, CYP19A1 3.9237
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, BCL2, ADORA1, PIK3CB 3.7224
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX15, PTGS2, PTGS1 3.6472
Pathways in cancer_Homo sapiens_hsa05200 PIK3CA, MMP1, MMP2, BCL2, PIK3CB, PTGS2, MMP9 3.1448
Metabolic pathways_Homo sapiens_hsa01100 HSD11B1, CBR1, CYP2A6, FUT7, ALOX15, CYP1A2, CYP1A1, ALPL, AKR1B1, PTGS2, CYP19A1, PTGS1 3.1051
Taste transduction_Homo sapiens_hsa04742 HTR1E, HTR1D, HTR1A, HTR1B 3.2277
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, BCL2, PIK3CB 3.006
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.4915
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, BCL2, PIK3CB, PTGS2 3.191
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, MMP2, PIK3CB, MMP9, ESR1 2.9274
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.9274
Hepatitis B_Homo sapiens_hsa05161 PIK3CA, BCL2, PIK3CB, MMP9 2.5255
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.8303
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, ADORA1, PIK3CB 2.3487
MicroRNAs in cancer_Homo sapiens_hsa05206 PIK3CA, BCL2, CYP1B1, PTGS2, MMP9 2.2935
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, PIK3CB, PTGS2 2.5449
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, PIK3CA, PIK3CB 3.006
Colorectal cancer_Homo sapiens_hsa05210 PIK3CA, BCL2, PIK3CB 2.539
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, PIK3CB, ESR1 2.391
Bladder cancer_Homo sapiens_hsa05219 MMP1, MMP2, MMP9 2.9918
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 3.006
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB 2.1872
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1 2.507
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, BCL2, PIK3CB 2.0291
Gap junction_Homo sapiens_hsa04540 HTR2B, HTR2C, HTR2A 2.1897
Insulin resistance_Homo sapiens_hsa04931 PIK3CA, PIK3CB, PPARA 1.9706
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, PIK3CB, ESR1 1.8945
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, BCL2, PIK3CB 1.8945
Platelet activation_Homo sapiens_hsa04611 PIK3CA, PIK3CB, PTGS1 1.8739
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, BCL2, PIK3CB 1.8841
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.7366
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA 1.7796
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB, PPARA 1.6731
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PIK3CB 1.6882
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIK3CB 1.6445
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, PIK3CB, PTGS2 1.6445
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, PIK3CA, BCL2, PIK3CB 1.5237
Epstein-Barr virus infection_Homo sapiens_hsa05169 PIK3CA, BCL2, PIK3CB 1.4787
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, BCL2, PIK3CB 1.4787
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, CNR1, PIK3CB 1.4414
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, PIK3CA, PIK3CB 1.4313
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, PIK3CA, PIK3CB 1.3768
Glioma_Homo sapiens_hsa05214 PIK3CA, PIK3CB 1.5237
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB 1.5272
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.5732
Pancreatic cancer_Homo sapiens_hsa05212 PIK3CA, PIK3CB 1.5237
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.52
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB 1.6525
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, PIK3CB 1.5237
Non-small cell lung cancer_Homo sapiens_hsa05223 PIK3CA, PIK3CB 1.6149
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB 1.5237
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, PIK3CB 1.608
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB 1.3261
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.4944
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.4147
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 MMP9 0.4004
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.3515
Tuberculosis_Homo sapiens_hsa05152 BCL2 0.4007
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, PIK3CB 1.3882
Chronic myeloid leukemia_Homo sapiens_hsa05220 PIK3CA, PIK3CB 1.4944
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB 1.5045
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB 1.3484
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 1.1379
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.5045
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB 1.3178
Measles_Homo sapiens_hsa05162 PIK3CA, PIK3CB 1.1292
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.3261
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB 1.1369
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 1.1302
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 1.3178
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB 1.1815
HTLV-I infection_Homo sapiens_hsa05166 PIK3CA, PIK3CB 0.7361
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, PIK3CB 0.8765
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 PIK3CA, PIK3CB 1.1054
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 1.2947
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, PIK3CB 1.0993
Insulin signaling pathway_Homo sapiens_hsa04910 PIK3CA, PIK3CB 1.1171
NF-kappa B signaling pathway_Homo sapiens_hsa04064 BCL2, PTGS2 1.3515
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB 1.3048
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1, PTGS2 1.3178
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB 0.9792
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.3048
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, PIK3CB 1.6938
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, PIK3CB 1.4589
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, PIK3CB 0.9389
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2 1.5147
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.7366
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5964
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.6123
GnRH signaling pathway_Homo sapiens_hsa04912 MMP2 0.6251
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.6119
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.6251
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.6251
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.6953
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.6938
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.7042
Bile secretion_Homo sapiens_hsa04976 CA2 0.7025
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.7357
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 2.0291
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B1 0.7602
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.8147
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.8441
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.1897
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6 0.8486
Galactose metabolism_Homo sapiens_hsa00052 AKR1B1 0.9952
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.9859
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B1 0.9389
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B1 0.9792
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 1.0461
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 1.0348
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2 3.2529
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.2655


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
Select to Download
1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)