Prescription Description
| Prescription ID | TCMF157 |
| Pinyin Name | Huang Lian Shang Qing Ke Li |
| Chinese Name | 黄连上清颗粒 |
| English Name | Huang Lian Shang Qing Granules |
| Function Description | 头晕脑胀, 牙龈肿痛, 口舌生疮, 咽喉红肿, 耳痛耳鸣, 大便干燥, 小便黄赤 |
| Indications | Tinnitus disorder, Gingivitis, Pharyngitis |
| Disease ICD-11 Category |
SC75 [Tinnitus disorder (TM1), 耳鸣 (TM1)
]; DA0B [Gingival diseases, 牙龈疾病 ]; CA0Z [Upper respiratory tract disorders, unspecified, 上呼吸道疾患，未特指的 ]; |
| Human Tissues Associated with Indication | Heart, Lung |
| Reference | Chinese pharmacopoeia (2015) |
| Reference Book/link | ISBN 978-7-5067-7337-9 |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH972 | Coptis chinensis | 黄连 | TCMH972 | ITSAO4469-14 |
| TCMH1272 | Forsythia suspensa | 连翘 | TCMH1272 | ITSAJ4444-14 |
| TCMH562 | Saposhnikovia divaricata | 防风 | TCMH562 | ITSAE3225-14 |
| TCMH118 | Angelica dahurica | 白芷 | TCMH118 | ITSAK3312-14 |
| TCMH1181 | Chrysanthemum morifolium | 菊花 | TCMH1181 | KX675020 |
| TCMH363 | Rheum officinale | 大黄 | TCMH363 | ITSAJ4685-14 |
| TCMH1080 | Platycodon grandiflorum | 桔梗 | TCMH1080 | ITSAJ4293-14 |
| TCMH1931 | Gypsum fibrosum | 石膏 | TCMH1931 | |
| TCMH628 | Glycyrrhiza uralensis | 甘草 | TCMH628 | ITSAM892-14 |
| TCMH2641 | Gardenia jasminoides | 栀子 | TCMH2641 | ITSAJ4473-14 |
| TCMH1432 | Vitex trifolia | 蔓荆子 | TCMH1432 | ITSAO4721-14 |
| TCMH1142 | Schizonepetae spica | 荆芥穗 | TCMH1142 | |
| TCMH986 | Scutellaria baicalensis | 黄芩 | TCMH986 | ITSAP4211-14 |
| TCMH188 | Mentha haplocalyx | 薄荷 | TCMH188 | HM595443 |
| TCMH949 | Phellodendron amurense | 黄柏 | TCMH949 | ITSAM1586-14 |
| TCMH305 | Cnidium officinale | 川芎 | TCMH305 | ITSAP4207-14 |
| TCMH2337 | Flos inulae | 旋覆花 | TCMH2337 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT100 | TTR | Transthyretin | Unclassified | P02766 |
| TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
| TCMT102 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | Hydrolase | P24666 |
| TCMT103 | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | Hydrolase | P10586 |
| TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
| TCMT114 | CNR2 | Cannabinoid CB2 receptor | GPCR | P34972 |
| TCMT115 | CNR1 | Cannabinoid CB1 receptor | GPCR | P21554 |
| TCMT126 | TERT | Telomerase reverse transcriptase | Transferase | O14746 |
| TCMT127 | PARP1 | Poly [ADP-ribose] polymerase-1 | Transferase | P09874 |
| TCMT128 | TNKS2 | Tankyrase-2 | Transferase | Q9H2K2 |
Showing 1 to 10 of 134 entries
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1170 | Enterobacter cloacae |
| TCMT1175 | Human immunodeficiency virus |
| TCMT1176 | Streptococcus pneumoniae |
| TCMT1178 | Actinomyces viscosus |
| TCMT1179 | Escherichia coli ATCC 8739 |
| TCMT1180 | Human herpesvirus 2 |
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
| TCMT1182 | Streptococcus sanguinis |
| TCMT1183 | Candida albicans SC5314 |
| TCMT1186 | Plasmodium yoelii yoelii |
Showing 1 to 10 of 93 entries
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|---|
| [BP] GO:0000302 | response to reactive oxygen species | AKR1B1, APEX1, AXL, BCL2, CYP1B1, MMP9, SRC | 2.83952 |
| [BP] GO:0001101 | response to acid chemical | AKR1B1, DNMT1, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC | 2.11853 |
| [BP] GO:0001503 | ossification | ALOX15, ALPL, BCL2, MMP2, MMP9 | 2.00378 |
| [BP] GO:0001659 | None | ADORA1, DRD1, DRD2, HTR2A | 2.98545 |
| [BP] GO:0001662 | None | BCL2, DRD1, HTR1A, HTR2C | 3.02922 |
| [BP] GO:0001666 | response to hypoxia | ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, PTGS2, SRC, TERT | 4.25683 |
| [BP] GO:0001676 | long-chain fatty acid metabolic process | ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 | 6.48127 |
| [BP] GO:0001932 | regulation of protein phosphorylation | ADORA1, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 4.25683 |
| [BP] GO:0001934 | positive regulation of protein phosphorylation | ADORA1, ALOX15, APP, BCL2, CDC25B, DRD2, FLT3, HTR2A, HTR2B, HTR2C, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 4.85361 |
| [BP] GO:0001952 | regulation of cell-matrix adhesion | BCL2, CDK6, KDR, PIK3CB, SRC | 2.16982 |
Showing 1 to 10 of 499 entries
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|
| ABC transporters_Homo sapiens_hsa02010 | ABCB1 | 0.6286 |
| Acute myeloid leukemia_Homo sapiens_hsa05221 | PIK3CA, FLT3, KIT, PIM1, PIK3CB | 4.2518 |
| Adherens junction_Homo sapiens_hsa04520 | PTPN1, CSNK2A1, SRC, MET, IGF1R | 3.8398 |
| Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.5049 |
| Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | PIK3CA, BCL2, PIK3CB | 1.246 |
| AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | PIK3CA, MMP2, BCL2, PIM1, PIK3CB, F3 | 4.2195 |
| Alcoholism_Homo sapiens_hsa05034 | DRD1, DRD2 | 0.6135 |
| Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | HSD11B2, PIK3CA, PIK3CB | 2.5252 |
| Alzheimer's disease_Homo sapiens_hsa05010 | BACE1, APP | 0.6291 |
| Amoebiasis_Homo sapiens_hsa05146 | PIK3CA, PIK3CB | 0.9234 |
Showing 1 to 10 of 166 entries
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples