Prescription Description
| Prescription ID | TCMF1366 |
| Pinyin Name | Bai He Gu Jin Wan |
| Chinese Name | 百合固金丸 |
| English Name | Baihe Gujin Pills |
| Function Description | 肺病咳嗽, 痰中带血, 午后痨热, 骨蒸盗汗, 干嗽无痰, 喘嗽音哑 |
| Indications | Upper respiratory infection(uri) |
| Disease ICD-11 Category |
CA0Z [Upper respiratory tract disorders, unspecified, 上呼吸道疾患，未特指的
]; |
| Human Tissues Associated with Indication | Lung |
| Reference | Chinese pharmacopoeia (2015) |
| Reference Book/link | ISBN 978-7-5067-7337-9 |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH62 | Lilium brownii | 百合 | TCMH62 | ITSAO2415-14 |
| TCMH1896 | Radix rehmanniae | 生地黄 | TCMH1896 | |
| TCMH1423 | Ophiopogon japonicus | 麦冬 | TCMH1423 | ITSAJ4140-14 |
| TCMH2343 | Scrophularia ningpoensis | 玄参 | TCMH2343 | ITSAO4295-14 |
| TCMH273 | Fritillaria cirrhosa | 川贝母 | TCMH273 | ITSAP3764-14 |
| TCMH421 | Angelica sinensis | 当归 | TCMH421 | ITSAF173-14 |
| TCMH104 | Paeonia lactiflora | 白芍 | TCMH104 | ITSAH2416-14 |
| TCMH78 | Platycodon grandiflorum | 白桔梗 | TCMH78 | ITSAJ4293-14 |
| TCMH628 | Glycyrrhiza uralensis | 甘草 | TCMH628 | ITSAM892-14 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT100 | TTR | Transthyretin | Unclassified | P02766 |
| TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
| TCMT102 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | Hydrolase | P24666 |
| TCMT103 | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | Hydrolase | P10586 |
| TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
| TCMT127 | PARP1 | Poly [ADP-ribose] polymerase-1 | Transferase | P09874 |
| TCMT128 | TNKS2 | Tankyrase-2 | Transferase | Q9H2K2 |
| TCMT129 | TNKS | Tankyrase-1 | Transferase | O95271 |
| TCMT13 | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | Lyase | P27695 |
| TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
Showing 1 to 10 of 99 entries
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1170 | Enterobacter cloacae |
| TCMT1175 | Human immunodeficiency virus |
| TCMT1176 | Streptococcus pneumoniae |
| TCMT1178 | Actinomyces viscosus |
| TCMT1179 | Escherichia coli ATCC 8739 |
| TCMT1180 | Human herpesvirus 2 |
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
| TCMT1186 | Plasmodium yoelii yoelii |
| TCMT1189 | Pseudomonas fluorescens |
| TCMT1190 | Plasmodium falciparum (isolate FcB1 / Columbia) |
Showing 1 to 10 of 67 entries
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|---|
| [BP] GO:0000302 | response to reactive oxygen species | AKR1B1, APEX1, AXL, BCL2, CYP1B1, MMP9, SRC | 3.33952 |
| [BP] GO:0001666 | response to hypoxia | ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, SRC | 2.38793 |
| [BP] GO:0001676 | long-chain fatty acid metabolic process | CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 2.45243 |
| [BP] GO:0002521 | leukocyte differentiation | AXL, BCL2, FLT3, FUT7, GLO1, MMP9, RORC | 2.37242 |
| [BP] GO:0006082 | organic acid metabolic process | ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, GLO1, PIM1, PPARA, TYR | 2.03378 |
| [BP] GO:0006145 | None | AOX1, XDH | 2.10095 |
| [BP] GO:0006352 | DNA-templated transcription, initiation | ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC | 2.101 |
| [BP] GO:0006367 | transcription initiation from RNA polymerase II promoter | ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC | 2.56588 |
| [BP] GO:0006468 | protein phosphorylation | AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC, TNKS | 2.6736 |
| [BP] GO:0006629 | lipid metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, PPARA | 8.40097 |
Showing 1 to 10 of 195 entries
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|
| Acute myeloid leukemia_Homo sapiens_hsa05221 | FLT3, PIM1 | 1.2623 |
| Adherens junction_Homo sapiens_hsa04520 | PTPN1, CSNK2A1, SRC, MET, IGF1R | 4.2038 |
| Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.5394 |
| Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | BCL2 | 0.3893 |
| AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | MMP2, BCL2, PIM1, F3 | 2.5914 |
| Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | HSD11B2 | 0.6686 |
| AMPK signaling pathway_Homo sapiens_hsa04152 | IGF1R | 0.4256 |
| Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | BCL2 | 0.6048 |
| Apoptosis_Homo sapiens_hsa04210 | BCL2 | 0.4013 |
| Arachidonic acid metabolism_Homo sapiens_hsa00590 | ALOX5 | 0.553 |
Showing 1 to 10 of 133 entries
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples