TCM Prescription: Brain-Invigorating and Kidney-Tonifying Pill



Prescription Description
Prescription IDTCMF1349
Pinyin NameJian Nao Bu Shen Wan
Chinese Name健脑补肾丸
English NameBrain-Invigorating and Kidney-Tonifying Pill
Function Description健忘, 不寐, 眩晕, 耳鸣, 心悸遗精
IndicationsInvoluntary ejaculation disorder, Tinnitus disorder, Vertigo disorder, Insomnia disorder
Disease ICD-11 Category SB09 [Involuntary ejaculation disorder (TM1), 遗精 (TM1) ];
SC75 [Tinnitus disorder (TM1), 耳鸣 (TM1) ];
SD22 [Vertigo disorder (TM1), 眩晕 (TM1) ];
SD84 [Insomnia disorder (TM1), 不寐 (TM1) ];
Human Tissues Associated with IndicationBrain, Heart
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2052 Ziziphus jujuba var. spinosa 酸枣仁 TCMH2052 ITSAM943-14
TCMH2554 Polygala tenuifolia 远志 TCMH2554 MF096619
TCMH1321 Os draconis 龙骨 TCMH1321
TCMH289 Cyathula officinalis 川牛膝 TCMH289 ITSAF2788-14
TCMH524 Eucommia ulmoides 杜仲 TCMH524 ITSAM1588-14
TCMH2682 Cinnabaris 朱砂 TCMH2682
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH943 Rhizoma dioscoreae 淮山药 TCMH943
TCMH1721 Panax ginseng 人参 TCMH1721 GBVE1679-11
TCMH1349 Cervus elaphus 鹿茸 TCMH1349 ABMC060-05
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT197 PDE4D Phosphodiesterase 4D Hydrolase Q08499
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT635 SLC6A3 Dopamine transporter Transporter Q01959
TCMT648 DRD4 Dopamine D4 receptor GPCR P21917
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT698 PDE4B Phosphodiesterase 4B Hydrolase Q07343
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT848 ERN1 Serine/threonine-protein kinase/endoribonuclease IRE1 Kinase O75460
TCMT907 FDPS Farnesyl diphosphate synthase Lyase P14324


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1172 Staphylococcus aureus subsp. aureus RN4220
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1292 Japanese encephalitis virus
TCMT1294 Human parainfluenza virus 3
TCMT1336 Yellow fever virus
TCMT1337 Dengue virus type 4
TCMT1338 Rift Valley fever virus
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1354 Streptococcus mutans UA159
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.6198
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.8187
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD2, ESR1, FABP3, FABP4, FDPS, HMGCR, HSD17B2, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 10.3928
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, FDPS, HMGCR, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TYR, XDH 10.3928
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSD17B2, KDR, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SLC1A1, SLC6A2, SLC6A3, SRC, XDH 9.5905
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 9.5905
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 9.4241
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, CA9, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, ESR1, FABP3, GRIK5, GRM5, HMGCR, HSD17B2, IGF1R, MMP2, MMP9, PIK3CA, PPARA, PTGS2, RORC, SLC6A3, SRC, TYR 9.12349
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD17B2, IGF1R, KDR, MMP2, PIK3CA, PPARA, PTGS2, RORC, SLC6A3, SRC, TYR 8.93287
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, DRD4, FABP3, PPARA, SLC1A1 8.90522
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 8.73125
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 8.45754
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, ALPL, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD17B2, IGF1R, KDR, MMP2, MMP9, PIK3CA, PPARA, PTGS2, RORC, SLC6A2, SLC6A3, SRC, TYR 8.21474
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD2, FABP3, FABP4, FDPS, HMGCR, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 8.10857
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, DRD2, DRD3, DRD4, GRIK5, GRM1, GRM3, GRM5, GRM8, PTGS2 7.50442
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, DRD2, DRD3, DRD4, GRIK5, GRM1, GRM3, GRM5, GRM8, PTGS2 7.50442
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, DRD4, FABP3, PPARA, SLC1A1 7.40229
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, ESR1, FDPS, HMGCR, HSD17B2 7.37191
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 7.28885
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 6.99869
[BP] GO:0007215 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 6.99139
[BP] GO:0007193 None ADORA1, DRD2, DRD3, DRD4, GRM1, GRM3, GRM5, GRM8 6.86052
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PPARA, PTGS1, PTGS2 6.60619
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, KDR, MMP9, PTGS2, SLC6A3, SRC 6.47915
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, AXL, CA2, CA7, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, FLT3, GRM1, HCAR2, HMGCR, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 6.4258
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, AXL, CA2, CA7, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, FLT3, GRM1, HCAR2, HMGCR, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 6.39878
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HMGCR, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 6.23523
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD2, GRM1, GRM3, GRM5, GRM8, PTGS2 6.1757
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AXL, CYP19A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, FABP4, GRM1, GRM5, GRM8, HMGCR, HSD17B2, IGF1R, MET, MMP1, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SLC6A2, SLC6A3, SRC, TYR 6.13576
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, CYP19A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, FDPS, HMGCR, SLC6A3, TYR 6.10588
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, DRD4, FABP3, GRIA2, GRIA4, GRIK5, PPARA, SLC1A1, SLC6A2, SLC6A3 6.06845
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, CDC25B, DRD2, DRD3, DRD4, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 6.04891
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, CDC25B, DRD2, DRD3, DRD4, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 5.98761
[BP] GO:0014070 response to organic cyclic compound ALPL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, FLT3, PTGS2, RORC, SLC6A3, SRC, TYR 5.88204
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.78776
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, DRD3, FABP3, FDPS, FLT3, HCAR2, HMGCR, PPARA, PTGS2, RORC, SRC 5.75712
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, AXL, CYP1B1, DRD2, DRD4, FLT3, GRM1, HMGCR, KDR, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.75208
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.75208
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.75208
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.69669
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, NQO2, PTGS1, RORC 5.65364
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.51073
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CYP1B1, CYP2D6, DRD2, DRD3, DRD4, ESR1, FABP4, GRM3, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC 5.40397
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, HMGCR, KDR, SLC6A3, SRC 5.35263
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.27119
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD2, DRD3, DRD4, GRIK5, PTGS2, SLC1A1, SLC6A2, SLC6A3 5.21806
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, CDC25B, DRD2, DRD4, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.21026
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CYP1B1, ESR1, FLT3, GRIK5, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, XDH 5.19879
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, AURKB, AXL, CA2, CA6, CA9, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HMGCR, HSD17B2, IGF1R, KDR, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A3, SRC, TYR 5.13991
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CDC25B, CYP19A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HCAR2, HMGCR, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC1A1, SLC6A3, SRC, XDH 5.13991
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, AXL, CA12, CA2, CA7, DRD2, DRD3, DRD4, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, MET, PIK3CA, PIK3CB, SRC 5.13902
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD2, DRD3, DRD4, ESR1, ESR2, FABP3, FABP4, FDPS, FLT3, HMGCR, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A3, SRC, TYR, XDH 5.13649
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, AURKB, AXL, CYP1B1, DRD2, DRD3, DRD4, ESR1, FLT3, GRM1, HMGCR, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.11732
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CYP1B1, ESR1, FLT3, GRIK5, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, XDH 5.08624
[BP] GO:0042493 response to drug AKR1B1, AXL, CA9, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, FABP3, HMGCR, KDR, PTGS2, SLC6A2, SLC6A3, SRC 5.08624
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, CDC25B, DRD2, DRD4, FABP3, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.08624
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, CDC25B, DRD2, DRD4, FABP3, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.08624
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CDC25B, CYP19A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, FABP3, FLT3, GRIK5, GRM1, GRM5, HCAR2, HMGCR, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, XDH 5.00559
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, CDC25B, DRD2, DRD4, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.99497
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD2, DRD3, DRD4, ESR1, ESR2, FABP3, FABP4, FDPS, FLT3, HMGCR, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A3, SRC, TYR, XDH 4.76968
[BP] GO:0007188 None ADORA1, DRD2, DRD3, DRD4, GRM1, GRM3, GRM5, GRM8 4.74154
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, DRD2, DRD3, HCAR2, HMGCR, KDR, PIK3CB, PTGS2, SRC 4.67194
[BP] GO:0032787 None ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PPARA, PTGS1, PTGS2 4.63909
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, AXL, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, MMP9, PIK3CA, PTGS2, RORC, SRC 4.59593
[BP] GO:0048878 chemical homeostasis AKR1B1, CA12, CA2, CA7, DRD2, DRD3, DRD4, ESR1, FABP3, FABP4, GRIK5, GRM1, GRM5, MET, PIK3CA, PIK3CB 4.52855
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, CDC25B, DRD2, DRD4, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 4.52126
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CYP1B1, ESR1, FLT3, GRIK5, HCAR2, HMGCR, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, XDH 4.52126
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.52126
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, AXL, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, PIK3CA, PTGS2, RORC, SRC 4.51625
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, AXL, CYP1B1, DRD2, DRD3, DRD4, FLT3, GRM1, HMGCR, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.49468
[BP] GO:0033993 response to lipid ALPL, AXL, CA2, CA9, CYP1A1, CYP1A2, ESR1, FABP3, FLT3, HSD17B2, PTGS2, RORC, SRC, TYR 4.43475
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, CDC25B, DRD2, DRD4, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.43438
[BP] GO:1900543 None DRD2, DRD3, DRD4, GRM3, GRM8, PPARA 4.4236
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, DRD2, DRD4, FLT3, GRM1, HMGCR, KDR, PIK3CB, PTPN1, SRC, XDH 4.3957
[BP] GO:0045980 None DRD2, DRD3, DRD4, GRM3, GRM8, PPARA 4.3952
[BP] GO:0032225 None DRD2, DRD3, DRD4, PTGS2 4.31362
[BP] GO:0007187 None ADORA1, DRD2, DRD3, DRD4, GRM1, GRM3, GRM5, GRM8 4.3074
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, DRD2, DRD3, DRD4, SLC6A3 4.27118
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FDPS, HMGCR 4.27112
[BP] GO:0060078 None ADORA1, DRD4, GRIA2, GRIA4, GRIK5, GRM5 4.25136
[BP] GO:0018958 None AKR1B1, DRD2, DRD3, DRD4, SLC6A3, TYR 4.22156
[BP] GO:0010243 response to organonitrogen compound AKR1B1, DRD2, DRD3, DRD4, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, PTGS2, SLC6A3, SRC, TYR 4.20595
[BP] GO:0006584 None AKR1B1, DRD2, DRD3, DRD4, SLC6A3 4.13118
[BP] GO:0009712 None AKR1B1, DRD2, DRD3, DRD4, SLC6A3 4.13118
[BP] GO:0030818 None DRD2, DRD3, DRD4, GRM3, GRM8 4.08951
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CYP19A1, CYP1A1, FDPS, HMGCR, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 4.08951
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, CDC25B, CYP1B1, DRD2, DRD3, ESR1, FABP3, FLT3, HMGCR, IGF1R, KDR, MMP2, MMP9, PIM1, PTGS1, PTGS2, SRC, XDH 4.04703
[BP] GO:0045859 regulation of protein kinase activity ADORA1, CDC25B, DRD2, DRD4, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, PIK3CA, PIK3CB, PTPN1, SRC 4.03948
[BP] GO:0030803 None DRD2, DRD3, DRD4, GRM3, GRM8 4.00603
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, CDC25B, DRD2, DRD4, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.9325
[BP] GO:0030815 None DRD2, DRD3, DRD4, GRM3, GRM8 3.92283
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD2, DRD3, DRD4, ESR1, ESR2, FABP3, FABP4, FDPS, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A3, SRC, TYR, XDH 3.92283
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, DRD3, MET, PIK3CA, PIK3CB, SRC, XDH 3.90545
[BP] GO:1900372 None DRD2, DRD3, DRD4, GRM3, GRM8 3.89295
[BP] GO:0030809 None DRD2, DRD3, DRD4, GRM3, GRM8 3.89295
[BP] GO:0007268 None DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 3.88032
[BP] GO:0098916 None DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 3.88032
[BP] GO:1901698 response to nitrogen compound AKR1B1, DRD2, DRD3, DRD4, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, PTGS2, SLC6A3, SRC, TYR 3.87357
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, HMGCR, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SRC 3.86614
[BP] GO:0030800 None DRD2, DRD3, DRD4, GRM3, GRM8 3.86428
[BP] GO:0099536 None DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 3.81054
[BP] GO:0099537 None DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 3.81054
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, DRD2, DRD4, FLT3, GRM1, HMGCR, IGF1R, KDR, PIK3CB, PTPN1, SRC, XDH 3.76491
[BP] GO:0042752 None ADORA1, DRD2, DRD3, DRD4, PPARA, RORC 3.73103
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 3.73103
[BP] GO:0043549 regulation of kinase activity ADORA1, CDC25B, DRD2, DRD4, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, PIK3CA, PIK3CB, PTPN1, SRC 3.73103
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD2, DRD3, HCAR2, PIK3CB, PTGS2 3.73103
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PIM1, PPARA, PTGS1, PTGS2, TYR 3.67494
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, IGF1R, KDR, MMP2, MMP9, PIK3CA, PTGS2, PTPN1, RORC, SRC 3.67116
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX15, AXL, CA2, CA7, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, GRIK5, GRM5, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SRC 3.66791
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, DRD2, ESR1, HCAR2, HMGCR, HSD17B2 3.66284
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX15, CYP19A1, FDPS, HMGCR, SLC6A3, TYR 3.63512
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, HMGCR, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SRC 3.63033
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, DRD2, DRD4, FLT3, GRM1, GRM5, PIK3CA, PIK3CB, PTPN1, SRC 3.63019
[BP] GO:0010038 response to metal ion ALOX15, CA2, CYP1A1, CYP1A2, DRD2, FABP4, MMP9, PTGS2, SLC6A3 3.61928
[BP] GO:1902532 negative regulation of intracellular signal transduction DRD2, DRD3, ESR1, HMGCR, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 3.6113
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CYP1B1, ESR1, GRIK5, GRM5, IGF1R, MMP2, MMP9, PIK3CA, PTGS2, RORC, SRC 3.57317
[BP] GO:0051338 regulation of transferase activity ADORA1, AURKB, CDC25B, DRD2, DRD4, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, PIK3CA, PIK3CB, PTPN1, SRC 3.57317
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FDPS 3.54583
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B2 3.52492
[BP] GO:0051940 None DRD2, DRD3, DRD4 3.51108
[BP] GO:0051584 None DRD2, DRD3, DRD4 3.51108
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, CA1, DRD2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 3.45969
[BP] GO:0042417 None DRD2, DRD3, DRD4, SLC6A3 3.45368
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DRD4, FLT3, GRM1, HMGCR, IGF1R, PIK3CB, PTPN1, SRC 3.42724
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, AXL, CYP1B1, DRD2, DRD3, DRD4, FABP4, FLT3, GRM1, HMGCR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.42424
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, DRD2, DRD4, FLT3, GRM1, GRM5, PIK3CA, PIK3CB, PTPN1, SRC 3.40478
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, DRD2, DRD3, DRD4, SLC6A3 3.3526
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, AXL, CA2, CA7, CYP19A1, DRD2, DRD3, DRD4, GRIK5, GRM5, HCAR2, HMGCR, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SRC 3.32478
[BP] GO:0015908 None DRD2, DRD3, DRD4, FABP3, PPARA 3.32309
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B2 3.31318
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ALOX15, CDC25B, DRD2, DRD4, ESR1, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.31084
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, CA2, CA7, DRD2, DRD4, PTGS2 3.28144
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, DRD2, DRD4, FLT3, GRM1, GRM5, PIK3CA, PIK3CB, PTPN1, SRC 3.27889
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PIM1, PPARA, PTGS1, PTGS2, TYR 3.2541
[BP] GO:0007194 None DRD2, DRD3, DRD4, GRM3 3.24865
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, DRD2 3.24865
[BP] GO:0007195 None DRD2, DRD3, DRD4 3.23492
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 3.23492
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.23492
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 3.19461
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PIM1, PPARA, PTGS1, PTGS2, TYR 3.18225
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, AURKB, CDC25B, CYP1B1, CYP2D6, DRD2, DRD3, DRD4, ESR1, ESR2, FABP4, FLT3, GRM1, GRM3, GRM5, HMGCR, IGF1R, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, XDH 3.17997
[BP] GO:0031280 None DRD2, DRD3, DRD4, GRM3 3.1593
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, AURKB, CDC25B, DRD2, DRD3, DRD4, ESR1, ESR2, FABP3, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SRC, XDH 3.1593
[BP] GO:0045936 None DRD2, DRD3, DRD4, FABP4, GRM3, GRM8, HMGCR, IGF1R, PPARA, PTPN1, XDH 3.13327
[BP] GO:0010563 None DRD2, DRD3, DRD4, FABP4, GRM3, GRM8, HMGCR, IGF1R, PPARA, PTPN1, XDH 3.12859
[BP] GO:0034776 None DRD2, DRD3, DRD4 3.12515
[BP] GO:0048511 rhythmic process AXL, DRD2, DRD3, DRD4, ESR1, PPARA, RORC, SRC 3.12312
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, CA2, CA9, CYP1A2, ESR1, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, PTGS2, SRC 3.11776
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, PTGS2 3.1103
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, AURKB, CDC25B, DRD2, DRD3, DRD4, ESR1, FABP4, FLT3, GRM1, GRM3, GRM5, HMGCR, IGF1R, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.10526
[BP] GO:0031399 regulation of protein modification process ADORA1, ALOX15, CDC25B, DRD2, DRD4, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.0926
[BP] GO:0051350 None DRD2, DRD3, DRD4, GRM3 3.08659
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, HMGCR, IGF1R, KDR, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SRC 3.08402
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, DRD2, DRD3, KDR, SRC 3.04775
[BP] GO:0032467 None AURKB, CDC25B, DRD2, DRD3 3.04775
[BP] GO:0046456 icosanoid biosynthetic process ALOX15, ALOX5, PTGS1, PTGS2 3.04775
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, CDC25B, DRD2, FDPS, FLT3, HMGCR, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, XDH 3.04775
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, CDC25B, DRD2, DRD4, ESR1, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.04755
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, CA2, CYP1A1, DRD2, DRD3, GRM1, HMGCR, MMP2, PPARA, PTGS2, SRC, TYR 3.04392
[BP] GO:0007154 None ADORA1, AXL, DRD2, DRD3, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, PTGS2, SLC1A1, SLC6A2 3.02729
[BP] GO:0043271 negative regulation of ion transport ADORA1, DRD2, DRD3, DRD4, MMP9, PTGS2 2.97928
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, AURKB, CDC25B, DRD2, DRD3, DRD4, ESR1, ESR2, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SRC, XDH 2.97247
[BP] GO:0007267 None ADORA1, DRD2, DRD3, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 2.95225
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CDC25B, DRD2, DRD3, ESR1, FLT3, HMGCR, IGF1R, KDR, MMP2, MMP9, PIM1, PTGS2 2.95086
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX15, CYP19A1, DRD2, DRD3, ESR1, ESR2, HMGCR, IGF1R, MET, MMP9, PPARA, PTGS2, PTPN1, SLC6A3, SRC, XDH 2.94631
[BP] GO:0060134 None DRD2, DRD3, SLC6A3 2.93466
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, FABP3, FABP4, MMP1, MMP2, MMP9, PIK3CB, SLC6A3, SRC, XDH 2.91768
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.87907
[BP] GO:0008217 None ADORA1, DRD2, DRD3, PPARA, PTGS1, PTGS2 2.86436
[BP] GO:0032147 activation of protein kinase activity ADORA1, DRD2, DRD4, GRM1, PIK3CA, PIK3CB, PTPN1, SRC 2.86392
[BP] GO:0045776 None ADORA1, DRD2, DRD3, PPARA 2.86345
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.8505
[BP] GO:0051580 None DRD2, DRD3, DRD4 2.8505
[BP] GO:0055082 cellular chemical homeostasis CA2, CA7, DRD2, DRD3, DRD4, ESR1, GRIK5, GRM1, GRM5, PIK3CA, PIK3CB 2.81084
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD2, DRD3, ESR1, FABP4, HMGCR, KDR, MET, PPARA, PTGS2, SLC6A3 2.80198
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, CDC25B, DRD2, FDPS, FLT3, HMGCR, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, XDH 2.80114
[BP] GO:0009725 response to hormone AKR1B1, ALPL, CA2, CA9, CYP1A2, ESR1, FABP3, FLT3, PPARA, PTGS2, SRC 2.77968
[BP] GO:0045761 None DRD2, DRD3, DRD4, GRM3 2.75778
[BP] GO:0050801 ion homeostasis CA12, CA2, CA7, DRD2, DRD3, DRD4, ESR1, FABP3, GRM1, GRM5, PIK3CB 2.72483
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 2.69686
[BP] GO:0044283 None AKR1B1, ALOX15, ALOX5, CYP19A1, CYP1A1, FDPS, HMGCR, PTGS1, PTGS2 2.68825
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.68788
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.68788
[BP] GO:0030817 None DRD2, DRD3, DRD4, GRM3, GRM8 2.65404
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, AURKB, AXL, CA2, CA9, CDC25B, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, ESR1, FABP4, FLT3, HMGCR, HSD17B2, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RORC, SLC6A3, SRC, TYR 2.61489
[BP] GO:0001504 None SLC1A1, SLC6A2, SLC6A3 2.61361
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, AURKB, CDC25B, DRD2, DRD3, DRD4, ESR1, ESR2, FABP3, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SRC, XDH 2.60146
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AXL, CA1, CA2, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTPN1, RORC, SRC 2.58039
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, AURKB, CDC25B, DRD2, DRD3, DRD4, ESR1, ESR2, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SRC, XDH 2.57921
[BP] GO:0023052 None ADORA1, DRD2, DRD3, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 2.57892
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, CYP1A1, CYP1B1, ESR1, FLT3, PTGS2, RORC, SRC 2.56308
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.56121
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, CA2, DRD2, DRD3, DRD4, ESR1, GRM1, GRM3, GRM5, GRM8, HCAR2, PIK3CA, PIK3CB, SRC 2.53348
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, DRD2, MMP2, PPARA, PTGS2, SRC 2.52493
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, PIM1, PPARA, RORC, SRC 2.52423
[BP] GO:0015909 None DRD2, DRD3, DRD4, FABP3 2.51909
[BP] GO:0099566 None GRM1, GRM5 2.51909
[BP] GO:0051944 None DRD2, DRD4 2.51909
[BP] GO:0060160 None DRD2, DRD3 2.51909
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.51909
[BP] GO:0051586 None DRD2, DRD4 2.51909
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, AURKB, AXL, CYP19A1, CYP1B1, CYP2D6, DRD2, DRD3, DRD4, ESR1, ESR2, FABP3, FABP4, GRM3, GRM8, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A3, SRC, XDH 2.50118
[BP] GO:0045187 None ADORA1, DRD2, DRD3 2.49995
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, DRD4, FLT3, GRM1, PIK3CB, PTPN1, SRC 2.49995
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.49995
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, CYP1A1, DRD2, PPARA 2.499
[BP] GO:0007626 None DRD2, DRD3, DRD4, GRM1, GRM5, SLC6A3 2.499
[BP] GO:0032922 None DRD2, DRD3, PPARA, RORC 2.47836
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, DRD2, MMP2, PPARA, PTGS2, SRC 2.47836
[BP] GO:0071702 None ADORA1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, DRD4, FABP3, PPARA, SLC1A1, SLC6A2, SLC6A3 2.46743
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.45117
[BP] GO:0048148 None DRD2, DRD3, DRD4 2.45049
[BP] GO:0035813 None ADORA1, DRD2, DRD3 2.45049
[BP] GO:0009892 negative regulation of metabolic process ADORA1, AURKB, CYP2D6, DRD2, DRD3, DRD4, ESR1, ESR2, FABP4, GRM3, GRM8, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SRC, XDH 2.44182
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.42168
[BP] GO:0042737 drug catabolic process ACHE, CYP1A2, CYP2A6, CYP2D6, SLC6A3 2.40786
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.39233
[BP] GO:0042749 None ADORA1, DRD2, DRD3 2.39233
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.38912
[BP] GO:0030814 None DRD2, DRD3, DRD4, GRM3, GRM8 2.37909
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CYP19A1, DRD2, DRD3, HMGCR, PPARA, SLC6A3 2.37804
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CYP19A1, CYP1A1, CYP1A2, ESR1, FLT3, HSD17B2, KDR, PIK3CA, PPARA, SRC, TYR 2.37419
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, AXL, CA2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, ESR1, FLT3, HSD17B2, KDR, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SLC6A3, SRC, TYR 2.37419
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, CYP19A1, CYP1B1, DRD2, DRD3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.35634
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD2, MET, PIK3CA 2.35292
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.34473
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ALOX15, AURKB, CA9, CDC25B, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD2, DRD3, DRD4, ESR1, ESR2, FABP3, FABP4, FDPS, FLT3, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A3, SRC, XDH 2.34049
[BP] GO:0030802 None DRD2, DRD3, DRD4, GRM3, GRM8 2.33986
[BP] GO:0031279 None DRD2, DRD3, DRD4, GRM3 2.33679
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DRD4, FLT3, GRM1, HMGCR, IGF1R, PIK3CB, PTPN1, SRC 2.32793
[BP] GO:0046777 protein autophosphorylation AURKB, FLT3, IGF1R, KDR, PIM1, SRC 2.32365
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, ALOX15, AURKB, AXL, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, FABP4, FLT3, GRM1, HMGCR, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SLC6A3, SRC, XDH 2.32154
[BP] GO:0051339 None DRD2, DRD3, DRD4, GRM3 2.31763
[BP] GO:0006810 None ACHE, ADORA1, ALOX15, ALOX5, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, DRD4, FABP3, GRIA2, GRIA4, GRIK5, MMP9, PPARA, SLC1A1, SLC6A2, SLC6A3, SRC, XDH 2.31423
[BP] GO:1903963 None DRD2, DRD3, DRD4 2.30526
[BP] GO:0044062 None ADORA1, DRD2, DRD3 2.30526
[BP] GO:0050482 None DRD2, DRD3, DRD4 2.30526
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.30526
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, DRD2, MMP2, PPARA, PTGS2, SRC 2.29986
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.29986
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.29986
[BP] GO:0051582 None DRD2, DRD4 2.29986
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.29986
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PTGS2, SRC 2.29986
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, CYP19A1, CYP1B1, DRD2, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.28482
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD2, PTGS2 2.28433
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, CYP19A1, CYP1B1, CYP2D6, DRD2, DRD3, DRD4, ESR1, ESR2, FABP3, FABP4, GRM3, GRM8, HMGCR, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, XDH 2.2766
[BP] GO:0098657 import into cell ACHE, ADORA1, ALOX15, AXL, DRD2, DRD3, SLC1A1, SLC6A2, SLC6A3 2.27476
[BP] GO:0042391 None ADORA1, DRD4, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC 2.27476
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC 2.27476
[BP] GO:0098771 inorganic ion homeostasis CA12, CA2, CA7, DRD2, DRD3, DRD4, ESR1, GRM1, GRM5, PIK3CB 2.27428
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B2 2.27428
[BP] GO:0008299 None CYP1A1, FDPS, HMGCR 2.27428
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.27428
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, FDPS, HMGCR, HSD17B2 2.26634
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, DRD2, FABP3, FABP4, MET, PIK3CA, PIK3CB 2.25431
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, ALOX15, AURKB, AXL, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, FLT3, GRM1, HMGCR, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.24521
[BP] GO:0044093 positive regulation of molecular function ADORA1, AURKB, CDC25B, DRD2, DRD4, ESR1, ESR2, FLT3, GRM1, GRM5, MET, MMP9, PIK3CA, PIK3CB, PTPN1, SRC, XDH 2.24521
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, PTGS2 2.2405
[BP] GO:0019725 cellular homeostasis CA2, CA7, DRD2, DRD3, DRD4, ESR1, GRIK5, GRM1, GRM5, PIK3CA, PIK3CB 2.23804
[BP] GO:0040014 regulation of multicellular organism growth DRD2, DRD3, PIK3CA, SLC6A3 2.22885
[BP] GO:1900371 None DRD2, DRD3, DRD4, GRM3, GRM8 2.22839
[BP] GO:0008283 cell proliferation ACHE, AURKB, CYP1A1, ESR1, FLT3, MET, PIK3CB, PIM1, SRC, TYR 2.22472
[BP] GO:0051179 None ACHE, ADORA1, ALOX15, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, DRD4, ESR1, FABP3, GRIA2, GRIA4, GRIK5, MMP9, PPARA, SLC1A1, SLC6A2, SLC6A3, SRC, XDH 2.21766
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, PPARA, RORC, SRC 2.21766
[BP] GO:0030808 None DRD2, DRD3, DRD4, GRM3, GRM8 2.21766
[BP] GO:0051234 None ACHE, ADORA1, ALOX15, ALOX5, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, DRD4, FABP3, GRIA2, GRIA4, GRIK5, MMP9, PPARA, SLC1A1, SLC6A2, SLC6A3, SRC, XDH 2.21441
[BP] GO:0032465 None AURKB, CDC25B, DRD2, DRD3 2.21263
[BP] GO:0015718 None DRD2, DRD3, DRD4, FABP3, PPARA 2.1959
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, HMGCR 2.1959
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5 2.1959
[BP] GO:0035235 None GRIA2, GRIA4, GRIK5 2.1959
[BP] GO:0032309 None DRD2, DRD3, DRD4 2.1959
[BP] GO:0001975 None DRD2, DRD3, DRD4 2.1959
[BP] GO:0007610 None DRD2, DRD3, DRD4, GRM1, GRM5, HMGCR, PPARA, PTGS2, SLC6A3 2.16257
[BP] GO:0007612 None DRD2, DRD3, GRM5, HMGCR, PTGS2 2.14148
[BP] GO:0090087 None ACHE, ADORA1, CA2, DRD2, DRD3, DRD4, HCAR2, HMGCR, PTGS2, PTPN1, SRC 2.13838
[BP] GO:0030100 regulation of endocytosis ALOX15, AXL, DRD2, PIK3CB, PTPN1, SRC 2.13334
[BP] GO:0042321 None ADORA1, DRD2 2.13334
[BP] GO:0090325 None DRD2, DRD3 2.13334
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, DRD2, DRD3, ESR1, ESR2, HMGCR, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 2.10519
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CYP19A1, DRD2, DRD3, DRD4, GRIK5, HCAR2, HMGCR, SRC 2.10519
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD4, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, SLC6A2, SRC 2.10044
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, CYP19A1, CYP1B1, DRD2, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.09914
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, DRD2, DRD3, ESR1, ESR2, HMGCR, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 2.09631
[BP] GO:0001101 response to acid chemical AKR1B1, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC 2.09328
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, ALOX15, AXL, PIK3CA, PIK3CB, PTGS1, PTGS2 2.08135
[BP] GO:0031214 biomineral tissue development ALOX15, ALPL, PPARA, PTGS2 2.08135
[BP] GO:0032413 None DRD2, DRD3, DRD4, MMP9 2.08135
[BP] GO:0071715 None DRD2, DRD3, DRD4 2.08135
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX15, PTGS1, PTGS2 2.08135
[BP] GO:0033280 response to vitamin D ALPL, PTGS2, TYR 2.08135
[BP] GO:1901571 None DRD2, DRD3, DRD4 2.08135
[BP] GO:0030799 None DRD2, DRD3, DRD4, GRM3, GRM8 2.0796
[BP] GO:0051952 None ADORA1, DRD2, DRD3, DRD4 2.06546
[BP] GO:0046717 None DRD2, DRD3, DRD4, SLC1A1 2.04459
[BP] GO:1901661 None AKR1B1, AKR1B10, HMGCR 2.0413
[BP] GO:0030003 cellular cation homeostasis CA2, CA7, DRD2, DRD3, DRD4, ESR1, GRM1, GRM5, PIK3CB 2.03751
[BP] GO:1900542 None DRD2, DRD3, DRD4, GRM3, GRM8, PPARA 2.00614
[BP] GO:0042220 None DRD2, DRD3, SLC6A3 2.00614
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling IGF1R, PIK3CA, PIK3CB 2.00614
[BP] GO:0045744 None DRD2, DRD3, MET 2.00614
[BP] GO:0010039 response to iron ion CYP1A1, DRD2, SLC6A3 2.00614
[BP] GO:0033029 regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.00381
[BP] GO:0032415 None DRD3, DRD4 2.00381
[BP] GO:0051934 None SLC6A2, SLC6A3 2.00381
[BP] GO:0021984 None DRD2, SLC6A3 2.00381
[BP] GO:0090494 None SLC6A2, SLC6A3 2.00381
[BP] GO:0090493 None SLC6A2, SLC6A3 2.00381
[BP] GO:0051583 None SLC6A2, SLC6A3 2.00381
[BP] GO:2001300 lipoxin metabolic process ALOX15, ALOX5 2.00381
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2D6 2.00381
[BP] GO:1901570 None ALOX15, ALOX5, PTGS1, PTGS2 2.00381
[BP] GO:0002791 None ACHE, ADORA1, DRD2, DRD3, DRD4, HCAR2, HMGCR, SRC 2.0024
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALOX15, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD2, DRD3, DRD4, ESR1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B2, IGF1R, KDR, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, SLC1A1, SLC6A2, SLC6A3, SRC, TYR 4.9327
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALOX15, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, DRD2, DRD3, DRD4, ESR1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTPN1, SLC1A1, SLC6A2, SLC6A3, SRC 4.69501
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX15, ALOX5, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD2, DRD3, DRD4, ESR1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B2, IGF1R, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SLC1A1, SLC6A2, SLC6A3, SRC, TYR 4.50078
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, MET, PTGS2, SLC1A1, SRC 4.37431
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, AXL, CA4, DRD2, DRD3, DRD4, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1, SLC6A2, SLC6A3 4.08951
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ALOX15, AXL, CA2, CA4, CA9, DRD2, DRD3, DRD4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PTGS2, SLC1A1, SLC6A2, SLC6A3, SRC 4.05924
[CC] GO:0044456 None ACHE, ADORA1, DRD2, DRD4, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SLC6A3, SRC 3.89295
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, AXL, DRD2, DRD3, DRD4, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1, SLC6A2, SLC6A3 3.75125
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.46802
[CC] GO:0043005 None ADORA1, CA2, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PTGS2, SLC6A2, SLC6A3, SRC 3.36337
[CC] GO:0014069 None ADORA1, DRD2, GRIK5, GRM1, GRM3, GRM5, SRC 3.1593
[CC] GO:0099572 None ADORA1, DRD2, GRIK5, GRM1, GRM3, GRM5, SRC 3.1593
[CC] GO:0098794 None ADORA1, DRD2, DRD4, GRIA2, GRIA4, GRM3 2.8247
[CC] GO:0042995 cell projection ADORA1, AKR1B1, CA2, DRD2, DRD3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PIK3CA, PTGS2, SLC6A2, SLC6A3, SRC 2.75156
[CC] GO:0120025 None ADORA1, AKR1B1, CA2, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PIK3CA, PTGS2, SLC6A2, SLC6A3, SRC 2.4911
[CC] GO:0043197 None ADORA1, DRD2, GRIA2, GRIA4, GRM3 2.35292
[CC] GO:0044309 None ADORA1, DRD2, GRIA2, GRIA4, GRM3 2.32692
[CC] GO:0097060 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 2.32133
[CC] GO:0005789 endoplasmic reticulum membrane CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, GRIA2, HMGCR, HSD17B2, PTGS1, PTGS2 2.27428
[CC] GO:0097458 None ADORA1, CA2, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, PTGS1, PTGS2, SLC6A2, SLC6A3, SRC 2.24521
[CC] GO:0044432 endoplasmic reticulum part CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FLT3, GRIA2, HMGCR, HSD17B2, PTGS1, PTGS2, PTPN1 2.08805
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.00381
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 17.0253
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, ESR1, ESR2, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, PTPN1, RORC, TYR, XDH 15.4481
[MF] GO:0043167 ion binding ACHE, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD2, DRD3, DRD4, ESR1, ESR2, FABP3, FABP4, FDPS, FLT3, HMGCR, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A3, SRC, TYR, XDH 11.3772
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.8187
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.6099
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD2, DRD3, DRD4, ESR1, ESR2, FDPS, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A3, TYR, XDH 9.4241
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 8.45754
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.35068
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2, SRC 7.64326
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HMGCR, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 7.43846
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2, SRC 7.40229
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FDPS, FLT3, HMGCR, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TYR, XDH 7.20111
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, ESR1, ESR2, FDPS, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A3, TYR, XDH 7.16263
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 7.01541
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2, TYR 6.99869
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, XDH 6.8868
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, MMP1, MMP2, MMP9, NQO2, PPARA, PTPN1, RORC 6.85475
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, DRD2, DRD3, DRD4, ESR1, ESR2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA, RORC 6.39004
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 6.3769
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 6.17551
[MF] GO:0030594 None DRD2, DRD3, DRD4, GRIA2, GRIA4, GRIK5, GRM1, GRM5 5.76437
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, DRD2, DRD3, DRD4, ESR1, ESR2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA, RORC 5.56455
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, DRD2, DRD3, DRD4, FLT3, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, SLC6A3, SRC 5.46112
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 5.43596
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HMGCR, NQO2, PTGS1, PTGS2, SRC, XDH 5.43133
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, DRD2, DRD3, DRD4, ESR1, ESR2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA, RORC 5.35289
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, DRD2, DRD3, DRD4, ESR1, ESR2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA, RORC 4.9327
[MF] GO:0035240 None DRD2, DRD3, DRD4, SLC6A3 4.63909
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2D6 4.56173
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, DRD2, DRD3, DRD4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET 4.37431
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, DRD2, DRD3, DRD4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET 4.37431
[MF] GO:1901338 None DRD2, DRD3, DRD4, SLC6A3 3.95148
[MF] GO:0001591 None DRD2, DRD3, DRD4 3.51108
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.46802
[MF] GO:0070405 ammonium ion binding ACHE, DRD2, DRD3, DRD4, SLC6A3 3.17196
[MF] GO:0043560 insulin receptor substrate binding IGF1R, PIK3CA, PIK3CB 3.12515
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.04755
[MF] GO:0004952 None DRD2, DRD3, DRD4 3.03333
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.91966
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.91966
[MF] GO:0008389 None CYP2A13, CYP2A6 2.91966
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, PPARA, RORC 2.62586
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, PPARA, RORC 2.62586
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.51909
[MF] GO:0005330 None SLC6A2, SLC6A3 2.51909
[MF] GO:0099583 None GRM1, GRM5 2.51909
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.49995
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.49995
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, NQO2, XDH 2.49995
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.47836
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, PPARA, RORC 2.37909
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.29986
[MF] GO:0004971 None GRIA2, GRIA4 2.29986
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX15, ALOX5, PTGS2 2.1959
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX15, ALOX5, PTGS2 2.14832
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HMGCR, HSD17B2, XDH 2.14148
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.13334
[MF] GO:0051721 None HMGCR, PTPN1, SLC6A3 2.10996
[MF] GO:0042802 identical protein binding ACHE, DRD2, DRD4, ESR1, ESR2, FLT3, GRIK5, HMGCR, IGF1R, KDR, MET, MMP9, NQO2, PTGS2, TYR, XDH 2.10052
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.00614
[MF] GO:0005329 None SLC6A2, SLC6A3 2.00381
[MF] GO:0004064 arylesterase activity CA1, CA2 2.00381


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 18.5206
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GRM3, GRIA2, GRM5, ADORA3, GRIK5, GRM8, ADORA1, DRD2, DRD3, DRD4, GRM1, GRIA4 7.9594
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 7.7607
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, GRM1, ESR2 7.2229
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 6.83
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, IGF1R 6.1444
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, ADORA1, PIK3CB, PTGS2, PTGS1 6.116
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, GRIA2, PIK3CA, ADORA1, PIK3CB, DRD2, PPARA, GRIA4 5.2837
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP2A6, CYP2A13, CYP2D6, CYP1A2, CYP1A1, CYP1B1 5.474
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2 5.2837
Metabolic pathways_Homo sapiens_hsa01100 FDPS, ALOX15, AKR1B1, HMGCR, PTGS2, TYR, CYP19A1, PTGS1, CYP2A6, AKR1B10, ALOX5, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH 4.4943
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 4.6264
Pathways in cancer_Homo sapiens_hsa05200 PIK3CA, FLT3, MMP1, MMP2, PIK3CB, PTGS2, MMP9, MET, IGF1R 4.1866
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1, ESR2 4.3297
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, KDR, PIK3CB, DRD2, MET, IGF1R 4.1866
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, DRD2, DRD3, SLC6A3, DRD4, GRIA4 4.3158
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 4.7016
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, PIK3CA, GRM8, PIK3CB, GRM1 4.1157
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, PTGS2, GRM1, GRIA4 3.776
Serotonergic synapse_Homo sapiens_hsa04726 CYP2D6, ALOX5, ALOX15, PTGS2, PTGS1 3.5791
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, PIK3CB, MET, IGF1R 3.4252
MicroRNAs in cancer_Homo sapiens_hsa05206 PIK3CA, PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B 3.4252
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.5707
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.0649
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2, DRD2, SLC6A3 3.776
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, PTGS2, PTGS1 3.4442
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET 3.3609
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB, MET, IGF1R 3.2923
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, PIM1, PIK3CB 2.7812
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 2.819
Adherens junction_Homo sapiens_hsa04520 PTPN1, SRC, MET, IGF1R 3.2364
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 3.1613
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.3262
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, DRD2, GRM1 2.9722
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.6641
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, PIK3CB, PPARA 2.6676
Ras signaling pathway_Homo sapiens_hsa04014 PIK3CA, KDR, PIK3CB, MET, IGF1R 2.4372
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.5387
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1 2.5717
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.5717
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, ADORA1, PIK3CB 2.5552
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB, HMGCR, IGF1R 2.5226
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB, GRM1, IGF1R 2.429
Hepatitis B_Homo sapiens_hsa05161 PIK3CA, SRC, PIK3CB, MMP9 2.3507
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2 2.2414
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, ADORA1, PIK3CB 2.1697
Glioma_Homo sapiens_hsa05214 PIK3CA, PIK3CB, IGF1R 2.3556
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.082
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB, IGF1R 2.3569
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 PIK3CA, KDR, PIK3CB, MET, IGF1R 1.8713
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.4289
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 2.3538
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, SLC6A3, GRIA4 2.3507
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PIK3CB 2.082
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.3538
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, PIK3CB 1.971
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.819
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, PIK3CB, IGF1R 2.068
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB, IGF1R 2.0082
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1 2.3556
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, PIK3CA, PIK3CB 1.8529
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, PIK3CB, PTGS2 2.0885
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, PIK3CB, IGF1R 1.9245
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.6447
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP2D6, CYP1A2 2.323
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, PIK3CB 1.7921
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA 1.6741
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB, PPARA 1.5646
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 PIK3CA, PIK3CB, IGF1R 1.6253
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, PIK3CB 1.6447
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, PIM1, PIK3CB 1.5227
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2346
Influenza A_Homo sapiens_hsa05164 FDPS, PIK3CA, PIK3CB 1.4312
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.3128
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3359
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3353
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, SRC, PIK3CB 1.292
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 PIK3CA, SRC, PIK3CB 1.2494
Tight junction_Homo sapiens_hsa04530 SRC 0.4108
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 1.3893
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.4444
Axon guidance_Homo sapiens_hsa04360 MET 0.439
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4444
Epstein-Barr virus infection_Homo sapiens_hsa05169 PIK3CA, PIK3CB 0.7347
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.0718
HTLV-I infection_Homo sapiens_hsa05166 FDPS, PIK3CA, PIK3CB 1.0957
Calcium signaling pathway_Homo sapiens_hsa04020 GRM5, GRM1 0.808
Alcoholism_Homo sapiens_hsa05034 DRD2, SLC6A3 0.8085
Apoptosis_Homo sapiens_hsa04210 PIK3CA, PIK3CB 0.965
Parkinson's disease_Homo sapiens_hsa05012 DRD2, SLC6A3 0.9582
Measles_Homo sapiens_hsa05162 PIK3CA, PIK3CB 0.9825
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5124
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5117
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, PIK3CB 0.9348
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 0.9842
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.9974
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5252
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5243
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5349
NF-kappa B signaling pathway_Homo sapiens_hsa04064 PTGS2 0.5299
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.536
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, PIK3CB 1.0656
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5379
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5379
Taste transduction_Homo sapiens_hsa04742 GRM1 0.5535
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB 1.1724
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 1.149
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.218
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 1.1739
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.536
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB 1.1597
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.2308
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 1.2055
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.1597
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.1854
Peroxisome_Homo sapiens_hsa04146 XDH 0.5535
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.5924
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5906
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6054
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.3893
Chronic myeloid leukemia_Homo sapiens_hsa05220 PIK3CA, PIK3CB 1.3893
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.4276
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6306
Shigellosis_Homo sapiens_hsa05131 SRC 0.6306
Pancreatic cancer_Homo sapiens_hsa05212 PIK3CA, PIK3CB 1.4375
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.402
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.6306
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR 1.402
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.4276
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.5054
Colorectal cancer_Homo sapiens_hsa05210 PIK3CA, PIK3CB 1.4836
Non-small cell lung cancer_Homo sapiens_hsa05223 PIK3CA, PIK3CB 1.5468
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.5141
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB 1.5976
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2 0.716
Malaria_Homo sapiens_hsa05144 MET 0.7286
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.7383
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, PIK3CB 1.6447
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.679
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.6722
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PIK3CA, PIK3CB 1.7875
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.7721
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.9666
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.2837
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.8471
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.9821
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.9245
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.8431
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.1391
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.9069
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.9431
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 FDPS, HMGCR 2.1697
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.1724


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)