Prescription Description
| Prescription ID | TCMF1349 |
| Pinyin Name | Jian Nao Bu Shen Wan |
| Chinese Name | 健脑补肾丸 |
| English Name | Brain-Invigorating and Kidney-Tonifying Pill |
| Function Description | 健忘, 不寐, 眩晕, 耳鸣, 心悸遗精 |
| Indications | Involuntary ejaculation disorder, Tinnitus disorder, Vertigo disorder, Insomnia disorder |
| Disease ICD-11 Category |
SB09 [Involuntary ejaculation disorder (TM1), 遗精 (TM1)
]; SC75 [Tinnitus disorder (TM1), 耳鸣 (TM1) ]; SD22 [Vertigo disorder (TM1), 眩晕 (TM1) ]; SD84 [Insomnia disorder (TM1), 不寐 (TM1) ]; |
| Human Tissues Associated with Indication | Brain, Heart |
| Reference | Chinese pharmacopoeia (2015) |
| Reference Book/link | ISBN 978-7-5067-7337-9 |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH2052 | Ziziphus jujuba var. spinosa | 酸枣仁 | TCMH2052 | ITSAM943-14 |
| TCMH2554 | Polygala tenuifolia | 远志 | TCMH2554 | MF096619 |
| TCMH1321 | Os draconis | 龙骨 | TCMH1321 | |
| TCMH289 | Cyathula officinalis | 川牛膝 | TCMH289 | ITSAF2788-14 |
| TCMH524 | Eucommia ulmoides | 杜仲 | TCMH524 | ITSAM1588-14 |
| TCMH2682 | Cinnabaris | 朱砂 | TCMH2682 | |
| TCMH421 | Angelica sinensis | 当归 | TCMH421 | ITSAF173-14 |
| TCMH943 | Rhizoma dioscoreae | 淮山药 | TCMH943 | |
| TCMH1721 | Panax ginseng | 人参 | TCMH1721 | GBVE1679-11 |
| TCMH1349 | Cervus elaphus | 鹿茸 | TCMH1349 | ABMC060-05 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
| TCMT102 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | Hydrolase | P24666 |
| TCMT103 | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | Hydrolase | P10586 |
| TCMT107 | GRIK2 | Glutamate receptor ionotropic kainate 2 | Ion channel | Q13002 |
| TCMT109 | GRIA2 | Glutamate receptor ionotropic, AMPA 2 | Ion channel | P42262 |
| TCMT110 | GRIA4 | Glutamate receptor ionotropic, AMPA 4 | Ion channel | P48058 |
| TCMT111 | GRIK5 | Glutamate receptor ionotropic kainate 5 | Ion channel | Q16478 |
| TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
| TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
| TCMT131 | ACHE | Acetylcholinesterase | Hydrolase | P22303 |
Showing 1 to 10 of 103 entries
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1170 | Enterobacter cloacae |
| TCMT1172 | Staphylococcus aureus subsp. aureus RN4220 |
| TCMT1175 | Human immunodeficiency virus |
| TCMT1176 | Streptococcus pneumoniae |
| TCMT1178 | Actinomyces viscosus |
| TCMT1179 | Escherichia coli ATCC 8739 |
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
| TCMT1182 | Streptococcus sanguinis |
| TCMT1189 | Pseudomonas fluorescens |
| TCMT1190 | Plasmodium falciparum (isolate FcB1 / Columbia) |
Showing 1 to 10 of 61 entries
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|---|
| [BP] GO:0001101 | response to acid chemical | AKR1B1, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC | 2.09328 |
| [BP] GO:0001504 | None | SLC1A1, SLC6A2, SLC6A3 | 2.61361 |
| [BP] GO:0001505 | regulation of neurotransmitter levels | ACHE, CYP1B1, DRD2, DRD3, DRD4, GRIK5, PTGS2, SLC1A1, SLC6A2, SLC6A3 | 5.21806 |
| [BP] GO:0001666 | response to hypoxia | ADORA1, CYP1A1, DRD2, MMP2, PPARA, PTGS2, SRC | 2.52493 |
| [BP] GO:0001676 | long-chain fatty acid metabolic process | ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 | 7.28885 |
| [BP] GO:0001932 | regulation of protein phosphorylation | ADORA1, ALOX15, CDC25B, DRD2, DRD4, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 4.43438 |
| [BP] GO:0001934 | positive regulation of protein phosphorylation | ADORA1, ALOX15, CDC25B, DRD2, DRD4, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 5.21026 |
| [BP] GO:0001975 | None | DRD2, DRD3, DRD4 | 2.1959 |
| [BP] GO:0002791 | None | ACHE, ADORA1, DRD2, DRD3, DRD4, HCAR2, HMGCR, SRC | 2.0024 |
| [BP] GO:0006082 | organic acid metabolic process | ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PIM1, PPARA, PTGS1, PTGS2, TYR | 3.18225 |
Showing 1 to 10 of 400 entries
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|
| Acute myeloid leukemia_Homo sapiens_hsa05221 | PIK3CA, FLT3, PIM1, PIK3CB | 3.5707 |
| Adherens junction_Homo sapiens_hsa04520 | PTPN1, SRC, MET, IGF1R | 3.2364 |
| Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.6054 |
| Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | PIK3CA, PIK3CB | 0.9348 |
| AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | PIK3CA, MMP2, PIM1, PIK3CB | 2.7812 |
| Alcoholism_Homo sapiens_hsa05034 | DRD2, SLC6A3 | 0.8085 |
| Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | PIK3CA, PIK3CB | 1.7875 |
| Amoebiasis_Homo sapiens_hsa05146 | PIK3CA, PIK3CB | 1.1739 |
| Amphetamine addiction_Homo sapiens_hsa05031 | GRIA2, SLC6A3, GRIA4 | 2.3507 |
| AMPK signaling pathway_Homo sapiens_hsa04152 | PIK3CA, PIK3CB, HMGCR, IGF1R | 2.5226 |
Showing 1 to 10 of 153 entries
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples