TCM-ID Component

Component: Siraitia grosvenorii 罗汉果

Description of the Component

Component ID	TCMH1370
Latin Name	Siraitia grosvenorii
English Name	Grosvenor siraitia
Chinese Pinyin Name	Luo Han Guo
中文名	罗汉果
TCM Properties	Cool,Sweet
TCM Meridians	Lung,Large Intestine
Therapeutic Class English	For desolving phlegm, stopping cougth, and soothing breathing
Therapeutic Class Chinese	化痰止咳平喘
Functions	remove heat, moisten the lung and relax the bowels
Toxicity	NA
Geo-authentic habitats (道地产区)	Guangxi Province
Reference	CFDA
Barcode ID	ITSAL2179-14
Barcode Source	BOLDSYSTEMS

TCM Prescriptions with the Component

Prescription ID	Prescription English Name	Prescription Chinese Name
TCMFx3329	Chuan Bei Luo Han Zhi Ke Infusion	川贝罗汉止咳冲剂
TCMFx7222	Fu Fang Luo Han Guo Qing Fei Syrup	复方罗汉果清肺糖浆
TCMFx3766	Fu Fang Luo Han Guo Zhi Ke Infusion	复方罗汉果止咳冲剂
TCMFx4109	Gui Lin Xi Gua Shuang	桂林西瓜霜
TCMFx4116	Gui Lin Xi Gua Shuang Capsules	桂林西瓜霜胶囊
TCMFx1975	Infusion of Grosvenor Momordica Fruit for Arresting Cough	罗汉果止咳冲剂
TCMFx6954	Jin Sang Zi Hou Tablets	金嗓子喉片
TCMFx7237	Luo Han Guo Ju Hua Granules	罗汉果菊花颗粒
TCMFx4887	Luo Han Guo Yu Zhu Infusion	罗汉果玉竹冲剂
TCMFx7175	Luo Han Guo Zhi Ke Capsules	罗汉果止咳胶囊
TCMFx4896	Luo Han Guo Zhi Ke Syrup	罗汉果止咳糖浆
TCMFx6929	Luo Han Guo Zhi Ke Tablets	罗汉果止咳片
TCMFx6978	Yin Hu Kang Gan Recipe	银胡抗感合剂
TCMFx6448	Zhi Ke Ding Chuan Tablets	止咳定喘片
TCMFx6937	Zhi Ke Ping Chuan Ointment	止咳平喘膏
TCMFx6527	Zhi Ke Ping Chuan Syrup	止咳平喘糖浆

Targeted Human Proteins by the Ingredient of Component

Target ID	Gene Symbol	Target Name	Target Class	Uniprot ID

Targeted Pathogenic Microbes by the Ingredient of Component

Target ID	Target Name

Ingredient Structrues

Ingredient ID: TCMC6832
Formula: C66H112O34

Common Name	MogrosideⅥ
IUPAC Name	(2R,3R,4S,5S,6R)-2-[[(2R,3S,4S,5R,6R)-6-[[(3S,8R,9R,10S,11R,13R,14S,17R)-17-[(2R,5R)-5-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl]oxy-6-hydroxy-6-methylheptan-2-yl]-11-hydroxy-4,4,9,13,14-pentamethyl-2,3,7,8,10,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-3,4-dihydroxy-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]methoxy]-6-(hydroxymethyl)oxane-3,4,5-triol
Canonical SMILES	OC[C@H]1O[C@@H](O[C@H]2[C@@H](O[C@@H]([C@H]([C@@H]2O)O)CO[C@@H]2O[C@H](CO)[C@H]([C@@H]([C@H]2O)O)O)O[C@@H](C(O)(C)C)CC[C@H]([C@H]2CC[C@@]3([C@]2(C)C[C@@H](O)[C@@]2([C@@H]3CC=C3[C@@H]2CC[C@@H](C3(C)C)O[C@@H]2O[C@H](CO[C@@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O)[C@H]([C@@H]([C@H]2O[C@@H]2O[C@H](CO)[C@H]([C@@H]([C@H]2O)O)O)O)O)C)C)C)[C@@H]([C@H]([C@@H]1O)O)O
Standard InCHI	InChI=1S/C66H112O34/c1-24(9-13-37(63(4,5)88)98-61-55(100-59-53(87)47(81)41(75)31(21-70)94-59)49(83)43(77)33(96-61)23-90-57-51(85)45(79)39(73)29(19-68)92-57)25-15-16-64(6)34-12-10-26-27(66(34,8)35(71)17-65(25,64)7)11-14-36(62(26,2)3)97-60-54(99-58-52(86)46(80)40(74)30(20-69)93-58)48(82)42(76)32(95-60)22-89-56-50(84)44(78)38(72)28(18-67)91-56/h10,24-25,27-61,67-88H,9,11-23H2,1-8H3/t24-,25-,27+,28-,29-,30-,31-,32-,33-,34-,35-,36+,37-,38-,39-,40-,41-,42-,43-,44+,45+,46+,47+,48+,49+,50-,51-,52-,53-,54-,55-,56-,57-,58+,59+,60+,61+,64+,65-,66+/m1/s1
Standard InCHIKey	LTDANPHZAHSOBN-IPIJHGFVSA-N
External Identifiers	ChEMBL [N/A]; PubChem [56843594];
Reference of Component-Ingredient Pair	28448136

Occurrence of the ingredient across TCM components

Component ID	Latin Name	Pinyin Name	Chinese Name
TCMH1370	Siraitia grosvenorii	Luo Han Guo	罗汉果

Ingredient ID: TCMC6817
Formula: C60H102O29

Common Name	Mogrosidev
IUPAC Name	(2R,3R,4S,5S,6R)-2-[[(3S,4S,5R,6R)-6-[[(3S,8S,9R,10R,11R,13R,14S,17R)-17-[(2R)-5-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-3-[(2R,3S,4R,5R,6S)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl]oxy-6-hydroxy-6-methylheptan-2-yl]-11-hydroxy-4,4,9,13,14-pentamethyl-2,3,7,8,10,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-3,4,5-trihydroxyoxan-2-yl]methoxy]-6-(hydroxymethyl)oxane-3,4,5-triol
Canonical SMILES	OC[C@@H]1O[C@H](O[C@H]2[C@@H](O[C@@H]([C@H]([C@@H]2O)O)CO[C@@H]2O[C@H](CO)[C@H]([C@@H]([C@H]2O)O)O)OC(C(O)(C)C)CC[C@H]([C@H]2CC[C@@]3([C@]2(C)C[C@@H](O)[C@@]2([C@H]3CC=C3[C@H]2CC[C@@H](C3(C)C)O[C@@H]2OC(CO[C@@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O)[C@H]([C@@H]([C@H]2O)O)O)C)C)C)[C@H]([C@@H]([C@H]1O)O)O
Standard InCHI	InChI=1S/C60H102O29/c1-23(9-13-35(57(4,5)79)88-55-50(89-54-49(78)43(72)38(67)29(20-63)84-54)45(74)40(69)31(86-55)22-81-52-47(76)42(71)37(66)28(19-62)83-52)24-15-16-58(6)32-12-10-25-26(60(32,8)33(64)17-59(24,58)7)11-14-34(56(25,2)3)87-53-48(77)44(73)39(68)30(85-53)21-80-51-46(75)41(70)36(65)27(18-61)82-51/h10,23-24,26-55,61-79H,9,11-22H2,1-8H3/t23-,24-,26-,27-,28-,29+,30?,31-,32+,33-,34+,35?,36-,37-,38+,39-,40-,41+,42+,43-,44+,45+,46-,47-,48-,49+,50-,51-,52-,53+,54-,55+,58+,59-,60+/m1/s1
Standard InCHIKey	GHBNZZJYBXQAHG-WQQTUWBJSA-N
External Identifiers	ChEMBL [N/A]; PubChem [53486251];
Reference of Component-Ingredient Pair	N/A

Occurrence of the ingredient across TCM components

Component ID	Latin Name	Pinyin Name	Chinese Name
TCMH1370	Siraitia grosvenorii	Luo Han Guo	罗汉果

Ingredient ID: TCMC2883
Formula: C6H12O6

Common Name	D-Glucose,Glucose
IUPAC Name	(3R,4S,5S,6R)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol
Canonical SMILES	OC[C@H]1OC(O)[C@@H]([C@H]([C@@H]1O)O)O
Standard InCHI	InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1
Standard InCHIKey	WQZGKKKJIJFFOK-GASJEMHNSA-N
External Identifiers	ChEMBL [CHEMBL1222250]; PubChem [5793];
Reference of Component-Ingredient Pair	22902238

Occurrence of the ingredient across TCM components

Component ID	Latin Name	Pinyin Name	Chinese Name
TCMH206	Fructus xanthii sibirici	Cang Er Zi	苍耳子
TCMH90	Imperata cylindrica	Bai Mao Gen	白茅根
TCMH31	Morinda officinalis	Ba Ji Tian	巴戟天
TCMH388	Ziziphus jujuba	Da Zao	大枣
TCMH1370	Siraitia grosvenorii	Luo Han Guo	罗汉果
TCMH1339	Phragmites communis	Lu Gen	芦根
TCMH1343	Aloe vera	Lu Hui	芦荟
TCMH1845	Dioscorea batatas	Shan Yao	山药
TCMH1862	Cornus officinalis	Shan Zhu Yu	山茱萸
TCMH1798	Morus alba	Sang Zhi	桑枝

Properties

Ingredient ID	Formulae	Name	MW	AlogP	MlogP	XlogP	# HBA	# HBD	PSA	# Rotatable Bond	# Ring	# Heacy Atom	Lipinski RO5 Violation
TCMC2883	C6H12O6	D-Glucose,Glucose	180.0633881	-2.5134	1.46	-1.697	6	5	110.38	1	1	12	0
TCMC6817	C60H102O29	Mogrosidev	1286.650677	-7.9145	4.87	-0.728	29	19	476.67	20	9	89	3
TCMC6832	C66H112O34	MogrosideⅥ	1448.703501	-9.6614	4.98	-2.265	34	22	555.82	23	10	100	3

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Data Section	Select to Download
1. General Information of the Component
2. TCM Prescriptions with the Component
3. Putative Targets
4. Activity & References for Filtering Putative Targets
5. Ingredient Data & Chemical Structure Information (Properties, InChI, InChIkey, SMILES, etc.)