NPASS Compound

Structure

NPC53494 OpenBabel06302215112D 25 26 0 0 0 0 0 0 0 0999 V2000 -1.7321 4.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -2.5981 4.5000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -3.4641 4.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -3.4641 3.0000 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 -4.3301 2.5000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -4.3301 1.5000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -5.1962 1.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -6.0622 1.5000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -6.0622 2.5000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -5.1962 3.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -6.9282 1.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -7.7942 1.5000 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 -6.9282 0.0000 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 -1.7321 3.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.8660 2.5000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.8660 1.5000 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 -0.0000 1.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 0.8660 1.5000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1.7321 1.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1.7321 0.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 0.8660 -0.5000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 -0.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5981 -0.5000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5981 -1.5000 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 3.4641 0.0000 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 0 0 0 1 14 1 0 0 0 0 2 3 1 0 0 0 0 3 4 1 0 0 0 0 4 5 1 0 0 0 0 5 10 2 0 0 0 0 5 6 1 0 0 0 0 6 7 2 0 0 0 0 7 8 1 0 0 0 0 8 9 2 0 0 0 0 8 11 1 0 0 0 0 9 10 1 0 0 0 0 11 12 2 0 0 0 0 11 13 1 0 0 0 0 14 15 1 0 0 0 0 15 16 1 0 0 0 0 16 17 1 0 0 0 0 17 22 2 0 0 0 0 17 18 1 0 0 0 0 18 19 2 0 0 0 0 19 20 1 0 0 0 0 20 21 2 0 0 0 0 20 23 1 0 0 0 0 21 22 1 0 0 0 0 23 24 2 0 0 0 0 23 25 1 0 0 0 0 M END $$$$

Physi-Chem Properties

Molecular Weight:	340.19
Volume:	360.543
LogP:	1.508
LogD:	0.643
LogS:	-3.476
# Rotatable Bonds:	10
TPSA:	118.2
# H-Bond Aceptor:	6
# H-Bond Donor:	6
# Rings:	2
# Heavy Atoms:	6

MedChem Properties

QED Drug-Likeness Score:	0.302
Synthetic Accessibility Score:	1.993
Fsp3:	0.263
Lipinski Rule-of-5:	Accepted
Pfizer Rule:	Accepted
GSK Rule:	Accepted
BMS Rule:	0
Golden Triangle Rule:	Accepted
Chelating Alert:	0
PAINS Alert:	0

ADMET Properties (ADMETlab2.0)

ADMET: Absorption

Caco-2 Permeability:	-5.898
MDCK Permeability:	0.00023246971250046045
Pgp-inhibitor:	0.778
Pgp-substrate:	1.0
Human Intestinal Absorption (HIA):	0.98
20% Bioavailability (F20%):	1.0
30% Bioavailability (F30%):	1.0

ADMET: Distribution

Blood-Brain-Barrier Penetration (BBB):	0.031
Plasma Protein Binding (PPB):	76.62887573242188%
Volume Distribution (VD):	1.567
Pgp-substrate:	26.62018585205078%

ADMET: Metabolism

CYP1A2-inhibitor:	0.05
CYP1A2-substrate:	0.836
CYP2C19-inhibitor:	0.039
CYP2C19-substrate:	0.069
CYP2C9-inhibitor:	0.026
CYP2C9-substrate:	0.031
CYP2D6-inhibitor:	0.026
CYP2D6-substrate:	0.543
CYP3A4-inhibitor:	0.024
CYP3A4-substrate:	0.34

ADMET: Excretion

Clearance (CL):	0.748
Half-life (T1/2):	0.368

ADMET: Toxicity

hERG Blockers:	0.657
Human Hepatotoxicity (H-HT):	0.819
Drug-inuced Liver Injury (DILI):	0.603
AMES Toxicity:	0.006
Rat Oral Acute Toxicity:	0.765
Maximum Recommended Daily Dose:	0.031
Skin Sensitization:	0.084
Carcinogencity:	0.083
Eye Corrosion:	0.003
Eye Irritation:	0.021
Respiratory Toxicity:	0.098

Download Data

Data Type	Select
General Info & Identifiers & Properties
Structure MOL file
Source Organisms
Biological Activities
Similar NPs/Drugs

Natural Product: NPC53494

Natural Product ID:	NPC53494
*Common Name:**	XDRYMKDFEDOLFX-UHFFFAOYSA-N
IUPAC Name:	n.a.
Synonyms:
Standard InCHIKey:	XDRYMKDFEDOLFX-UHFFFAOYSA-N
Standard InCHI:	InChI=1S/C19H24N4O2/c20-18(21)14-4-8-16(9-5-14)24-12-2-1-3-13-25-17-10-6-15(7-11-17)19(22)23/h4-11H,1-3,12-13H2,(H3,20,21)(H3,22,23)
SMILES:	C(CCOc1ccc(cc1)C(=N)N)CCOc1ccc(cc1)C(=N)N
Synthetic Gene Cluster:	n.a.
ChEMBL Identifier:	n.a.
PubChem CID:	4735
Chemical Classification:**	CHEMONTID:0000000 [Organic compounds] [CHEMONTID:0002448] Benzenoids [CHEMONTID:0002341] Phenol ethers

*Note: the InCHIKey will be temporarily assigned as the "Common Name" if no IUPAC name or alternative short name is available.
**Note: the Chemical Classification was calculated by NPClassifier Version 1.5. Reference: PMID:34662515.

Species Source

Organism ID	Organism Name	Taxonomy Level	Family	SuperKingdom	Isolation Part	Collection Location	Collection Time	Reference
NPO33280	Acanthostrongylophora sp.	Species	Petrosiidae	Eukaryota	n.a.	n.a.	n.a.	PMID[15332848]
NPO33280	Acanthostrongylophora sp.	Species	Petrosiidae	Eukaryota	n.a.	collected from vertical slopes between 33 and 40 m from Knife Cape Manado, Indonesia	n.a.	PMID[16872140]
NPO33280	Acanthostrongylophora sp.	Species	Petrosiidae	Eukaryota	n.a.	collected from vertical slopes between 33 and 40 m from Knife Cape Manado, Indonesia	2004-Mar	PMID[16872140]
NPO33280	Acanthostrongylophora sp.	Species	Petrosiidae	Eukaryota	n.a.	Indonesian	n.a.	PMID[16872140]
NPO33280	Acanthostrongylophora sp.	Species	Petrosiidae	Eukaryota	n.a.	collected from vertical slopes between 33 and 40 m from Knife Cape Manado, Indonesia	2002-May	PMID[16872140]
NPO40258	Oxandra espintana	Species	Annonaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[1919589]
NPO33084	Geosmithia langdonii	Species	Bionectriaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[25084548]
NPO40183	Leishmania amazonensis	Species	Trypanosomatidae	Eukaryota	n.a.	n.a.	n.a.	PMID[26169126]
NPO33280	Acanthostrongylophora sp.	Species	Petrosiidae	Eukaryota	n.a.	n.a.	n.a.	PMID[28452477]
NPO33084	Geosmithia langdonii	Species	Bionectriaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[30298736]
NPO17403	Peperomia galioides	Species	Piperaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[7769398]
NPO17403	Peperomia galioides	Species	Piperaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[8759169]
NPO17403	Peperomia galioides	Species	Piperaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]

☑ Note for Reference:
In addition to directly collecting NP source organism data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated them from below databases:
☉ UNPD: Universal Natural Products Database [PMID: 23638153].
☉ StreptomeDB: a database of streptomycetes natural products [PMID: 33051671].
☉ TM-MC: a database of medicinal materials and chemical compounds in Northeast Asian traditional medicine [PMID: 26156871].
☉ TCM@Taiwan: a Traditional Chinese Medicine database [PMID: 21253603].
☉ TCMID: a Traditional Chinese Medicine database [PMID: 29106634].
☉ TCMSP: The traditional Chinese medicine systems pharmacology database and analysis platform [PMID: 24735618].
☉ HerDing: a herb recommendation system to treat diseases using genes and chemicals [PMID: 26980517].
☉ MetaboLights: a metabolomics database [PMID: 27010336].
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].

NP Quantity Composition/Concentration

Organism ID	NP ID	Organism Material Preparation	Organism Part	NP Quantity (Standard)	NP Quantity (Minimum)	NP Quantity (Maximum)	Quantity Unit	Reference

☑ Note for Reference:
In addition to directly collecting NP quantitative data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated NP quantitative records for specific NP domains (e.g., NPS from foods or herbs) from domain-specific databases. These databases include:
☉ DUKE: Dr. Duke's Phytochemical and Ethnobotanical Databases.
☉ PHENOL EXPLORER: is the first comprehensive database on polyphenol content in foods [PMID: 24103452], its homepage can be accessed at here.
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].

Biological Activity

Activity Type	# Activity
EC50	100
ED50	11
GI50	2
IC50	508
Kd	5
Ki	7
LD50	2
MIC	13
Others	329

Activity Type	# Activity
Cell Line	86
CELL-LINE	5
Individual Protein	45
NON-MOLECULAR	21
Organism	642
Others	145
Protein Complex	21
SINGLE PROTEIN	15
Uncleic Acid	1

Target ID	Target Type	Target Name	Target Organism	Activity Type	Activity Relation	Value	Unit	Reference
NPT1224	Individual Protein	Glyceraldehyde-3-phosphate dehydrogenase liver	Homo sapiens	IC50	>	50000.0	nM	PMID[11405646]
NPT5080	Individual Protein	Matriptase	Homo sapiens	Ki	=	1160.0	nM	PMID[11311057]
NPT81	Cell Line	A549	Homo sapiens	IC50	=	40.0	nM	PMID[15115412]
NPT81	Cell Line	A549	Homo sapiens	IC50	=	24000.0	nM	PMID[15357989]
NPT839	Cell Line	L6	Rattus norvegicus	TD50	=	1.5	uM	PMID[16107146]
NPT5467	Individual Protein	Protein-tyrosine phosphatase 4A3	Homo sapiens	IC50	=	53600.0	nM	PMID[16530413]
NPT839	Cell Line	L6	Rattus norvegicus	IC50	=	2100.0	nM	PMID[16913722]
NPT839	Cell Line	L6	Rattus norvegicus	IC50	=	46.6	nM	PMID[17178177]
NPT839	Cell Line	L6	Rattus norvegicus	IC50	=	46600.0	nM	PMID[17948982]
NPT189	Cell Line	Vero	Chlorocebus aethiops	IC50	=	13700.0	nM	PMID[17880175]
NPT5467	Individual Protein	Protein-tyrosine phosphatase 4A3	Homo sapiens	IC50	=	53600.0	nM	PMID[18358718]
NPT189	Cell Line	Vero	Chlorocebus aethiops	IC50	>	100000.0	nM	PMID[18367395]
NPT171	Cell Line	MRC5	Homo sapiens	IC50	=	5.71	ug.mL-1	PMID[19013823]
NPT91	Cell Line	KB	Homo sapiens	IC50	=	0.11	ug.mL-1	PMID[12398543]
NPT839	Cell Line	L6	Rattus norvegicus	IC50	=	46600.0	nM	PMID[18841956]
NPT1182	Cell Line	J774.A1	Mus musculus	CC50	=	25.15	n.a.	PMID[19328690]
NPT189	Cell Line	Vero	Chlorocebus aethiops	IC50	>	50.0	ug.mL-1	PMID[15679330]
NPT1182	Cell Line	J774.A1	Mus musculus	IC50	=	12.9	ug.mL-1	PMID[15679330]
NPT1182	Cell Line	J774.A1	Mus musculus	CC50	=	31.31	ug.mL-1	PMID[19091566]
NPT1182	Cell Line	J774.A1	Mus musculus	CC50	=	31.31	ug.mL-1	PMID[19217698]
NPT839	Cell Line	L6	Rattus norvegicus	IC50	=	46600.0	nM	PMID[19606902]
NPT839	Cell Line	L6	Rattus norvegicus	IC50	=	46600.0	nM	PMID[19757840]
NPT839	Cell Line	L6	Rattus norvegicus	IC50	=	46600.0	nM	PMID[19409677]
NPT839	Cell Line	L6	Rattus norvegicus	IC50	=	46600.0	nM	PMID[19928900]
NPT1229	Cell Line	Huh-7	Homo sapiens	CC50	>	6250.0	nM	PMID[18579783]
NPT839	Cell Line	L6	Rattus norvegicus	IC50	=	2100.0	nM	PMID[19699098]
NPT1182	Cell Line	J774.A1	Mus musculus	CC50	=	31.31	ug.mL-1	PMID[19913413]
NPT81	Cell Line	A549	Homo sapiens	IC50	=	24000.0	nM	PMID[19736009]
NPT839	Cell Line	L6	Rattus norvegicus	IC50	=	3800.0	nM	PMID[20303767]
NPT839	Cell Line	L6	Rattus norvegicus	IC50	=	46600.0	nM	PMID[20403703]
NPT470	Individual Protein	Rhodesain	Trypanosoma brucei rhodesiense	Inhibition	=	28.0	%	PMID[19715342]
NPT1182	Cell Line	J774.A1	Mus musculus	CC50	=	52820.0	nM	PMID[20371140]
NPT1182	Cell Line	J774.A1	Mus musculus	CC50	=	3.91	ug.mL-1	PMID[20199824]
NPT71	Cell Line	HEK293	Homo sapiens	Inhibition	=	58.3	%	PMID[20558060]
NPT1182	Cell Line	J774.A1	Mus musculus	CC50	=	25.15	ug.mL-1	PMID[20457476]
NPT1970	Cell Line	THP-1	Homo sapiens	IC50	=	31200.0	nM	PMID[20833057]
NPT1182	Cell Line	J774.A1	Mus musculus	CC50	=	52820.0	nM	PMID[20850302]
NPT2679	Cell Line	LLC-MK2	Macaca mulatta	IC50	=	25610.0	nM	PMID[20934347]
NPT839	Cell Line	L6	Rattus norvegicus	IC50	=	25000.0	nM	PMID[21112788]
NPT839	Cell Line	L6	Rattus norvegicus	IC50	=	6000.0	nM	PMID[21194955]
NPT839	Cell Line	L6	Rattus norvegicus	IC50	=	46000.0	nM	PMID[21421317]
NPT839	Cell Line	L6	Rattus norvegicus	IC50	=	46000.0	nM	PMID[20031421]
NPT189	Cell Line	Vero	Chlorocebus aethiops	CC50	=	47000.0	nM	PMID[21397502]
NPT1182	Cell Line	J774.A1	Mus musculus	IC50	=	1030.0	nM	PMID[21555166]
NPT71	Cell Line	HEK293	Homo sapiens	IC50	=	71000.0	nM	PMID[21705225]
NPT839	Cell Line	L6	Rattus norvegicus	IC50	=	2100.0	nM	PMID[22005186]
NPT1886	Cell Line	J774	Mus musculus	IC50	=	70000.0	nM	PMID[22000949]
NPT113	Cell Line	RAW264.7	Mus musculus	Survival	=	75.0	%	PMID[22472166]
NPT1182	Cell Line	J774.A1	Mus musculus	CC50	=	1000.0	nM	PMID[22608675]
NPT65	Cell Line	HepG2	Homo sapiens	CC50	=	2300.0	nM	PMID[22608675]
NPT165	Cell Line	HeLa	Homo sapiens	IC50	=	15000.0	nM	PMID[23164660]
NPT113	Cell Line	RAW264.7	Mus musculus	IC50	=	30000.0	nM	PMID[22989363]
NPT375	Cell Line	Malme-3M	Homo sapiens	IC50	=	12200.0	nM	PMID[23264854]
NPT375	Cell Line	Malme-3M	Homo sapiens	IC50	=	10200.0	nM	PMID[23264854]
NPT839	Cell Line	L6	Rattus norvegicus	IC50	=	1510.0	nM	PMID[23301592]
NPT91	Cell Line	KB	Homo sapiens	CC50	=	52700.0	nM	PMID[23182089]
NPT4037	Individual Protein	Multidrug and toxin extrusion protein 1	Homo sapiens	IC50	=	410.0	nM	PMID[23241029]
NPT4037	Individual Protein	Multidrug and toxin extrusion protein 1	Homo sapiens	IC50	=	2000.0	nM	PMID[23241029]
NPT4036	Individual Protein	Multidrug and toxin extrusion protein 2	Homo sapiens	IC50	=	2700.0	nM	PMID[23241029]
NPT1546	Individual Protein	Solute carrier family 22 member 3	Homo sapiens	IC50	=	9500.0	nM	PMID[23241029]
NPT613	Individual Protein	Solute carrier family 22 member 1	Homo sapiens	IC50	=	22100.0	nM	PMID[23241029]
NPT1540	Individual Protein	Solute carrier family 22 member 2	Homo sapiens	IC50	=	1200.0	nM	PMID[23241029]
NPT4036	Individual Protein	Multidrug and toxin extrusion protein 2	Homo sapiens	IC50	=	10400.0	nM	PMID[23241029]
NPT4037	Individual Protein	Multidrug and toxin extrusion protein 1	Homo sapiens	IC50	=	2700.0	nM	PMID[23241029]
NPT1653	Cell Line	WM-115	Homo sapiens	IC50	=	4800.0	nM	PMID[23375094]
NPT839	Cell Line	L6	Rattus norvegicus	IC50	=	46600.0	nM	PMID[23795673]
NPT189	Cell Line	Vero	Chlorocebus aethiops	IC50	=	57000.0	nM	PMID[23727538]
NPT839	Cell Line	L6	Rattus norvegicus	IC50	=	46600000.0	nM	PMID[23871911]
NPT113	Cell Line	RAW264.7	Mus musculus	CC50	=	25500.0	nM	PMID[24125880]
NPT839	Cell Line	L6	Rattus norvegicus	IC50	=	2100.0	nM	PMID[24012380]
NPT65	Cell Line	HepG2	Homo sapiens	CC50	=	2300.0	nM	PMID[24080103]
NPT189	Cell Line	Vero	Chlorocebus aethiops	CC50	=	85860.0	nM	PMID[24900613]
NPT171	Cell Line	MRC5	Homo sapiens	IC50	=	5.7	ug.mL-1	PMID[24388808]
NPT839	Cell Line	L6	Rattus norvegicus	IC50	=	46600.0	nM	PMID[24268543]
NPT189	Cell Line	Vero	Chlorocebus aethiops	CC50	=	47000.0	nM	PMID[24529307]
NPT65	Cell Line	HepG2	Homo sapiens	IC50	=	159710.0	nM	PMID[24630563]
NPT540	Individual Protein	Bile acid receptor FXR	Homo sapiens	Activity	=	9.2	%	PMID[24630693]
NPT65	Cell Line	HepG2	Homo sapiens	CC50	=	2300.0	nM	PMID[24858543]
NPT839	Cell Line	L6	Rattus norvegicus	IC50	=	46600.0	nM	PMID[24956553]
NPT113	Cell Line	RAW264.7	Mus musculus	Survival	=	85.6	%	PMID[25281268]
NPT1970	Cell Line	THP-1	Homo sapiens	IC50	>	10.0	ug.mL-1	PMID[25240614]
NPT65	Cell Line	HepG2	Homo sapiens	CC50	=	2300.0	nM	PMID[25846065]
NPT1970	Cell Line	THP-1	Homo sapiens	IC50	=	31200.0	nM	PMID[25846065]
NPT65	Cell Line	HepG2	Homo sapiens	CC50	=	2300.0	nM	PMID[25559208]
NPT1970	Cell Line	THP-1	Homo sapiens	CC50	=	31200.0	nM	PMID[25559208]
NPT1886	Cell Line	J774	Mus musculus	LC50	>	100000.0	nM	PMID[26107111]
NPT1886	Cell Line	J774	Mus musculus	Activity	=	28.8	%	PMID[26107111]
NPT839	Cell Line	L6	Rattus norvegicus	IC50	=	31800.0	nM	PMID[27102161]
NPT81	Cell Line	A549	Homo sapiens	GI50	>	100000.0	nM	PMID[28064141]
NPT208	Individual Protein	Cytochrome P450 1A2	Homo sapiens	IC50	>	100000.0	nM	PMID[28064141]
NPT212	Individual Protein	Cytochrome P450 2C9	Homo sapiens	IC50	>	100000.0	nM	PMID[28064141]
NPT213	Individual Protein	Cytochrome P450 2C19	Homo sapiens	IC50	>	100000.0	nM	PMID[28064141]
NPT110	Individual Protein	Cytochrome P450 2D6	Homo sapiens	IC50	=	24800.0	nM	PMID[28064141]
NPT109	Individual Protein	Cytochrome P450 3A4	Homo sapiens	IC50	>	100000.0	nM	PMID[28064141]
NPT1970	Cell Line	THP-1	Homo sapiens	IC50	=	7700.0	nM	PMID[28012342]
NPT466	Cell Line	U-937	Homo sapiens	IC50	=	6020.0	nM	PMID[28012342]
NPT612	Individual Protein	Canalicular multispecific organic anion transporter 1	Homo sapiens	IC50	>	133000.0	nM	PMID[23956101]
NPT1249	Individual Protein	Canalicular multispecific organic anion transporter 2	Homo sapiens	IC50	>	133000.0	nM	PMID[23956101]
NPT1028	Individual Protein	Multidrug resistance-associated protein 4	Homo sapiens	IC50	>	133000.0	nM	PMID[23956101]
NPT189	Cell Line	Vero	Chlorocebus aethiops	CC50	=	47000.0	nM	PMID[28645659]
NPT4245	Individual Protein	Protein-arginine N-methyltransferase 1	Homo sapiens	IC50	=	81000.0	nM	PMID[28649316]
NPT6106	Individual Protein	Protein arginine N-methyltransferase 5	Homo sapiens	IC50	=	582000.0	nM	PMID[28649316]
NPT1970	Cell Line	THP-1	Homo sapiens	CC50	=	10000.0	nM	PMID[29407968]
NPT81	Cell Line	A549	Homo sapiens	IC50	>	100000.0	nM	PMID[29407968]
NPT208	Individual Protein	Cytochrome P450 1A2	Homo sapiens	IC50	>	100000.0	nM	PMID[29407968]
NPT212	Individual Protein	Cytochrome P450 2C9	Homo sapiens	IC50	>	100000.0	nM	PMID[29407968]
NPT213	Individual Protein	Cytochrome P450 2C19	Homo sapiens	IC50	>	100000.0	nM	PMID[29407968]
NPT110	Individual Protein	Cytochrome P450 2D6	Homo sapiens	IC50	=	24800.0	nM	PMID[29407968]
NPT109	Individual Protein	Cytochrome P450 3A4	Homo sapiens	IC50	>	100000.0	nM	PMID[29407968]
NPT1433	Individual Protein	Serine/threonine-protein kinase Aurora-B	Homo sapiens	IC50	>	100000.0	nM	PMID[29407968]
NPT401	Cell Line	786-0	Homo sapiens	IC50	>	100000.0	nM	PMID[29407968]
NPT81	Cell Line	A549	Homo sapiens	IC50	=	23500.0	nM	PMID[30108719]
NPT1720	Individual Protein	Plasminogen	Homo sapiens	IC50	=	8400.0	nM	PMID[31658420]
NPT2533	Individual Protein	Coagulation factor X	Homo sapiens	IC50	=	10400.0	nM	PMID[31658420]
NPT1720	Individual Protein	Plasminogen	Homo sapiens	IC50	=	3600.0	nM	PMID[31658420]
NPT65	Cell Line	HepG2	Homo sapiens	CC50	=	2300.0	nM	PMID[30655943]
NPT208	Individual Protein	Cytochrome P450 1A2	Homo sapiens	IC50	>	25000.0	nM	PMID[30908048]
NPT212	Individual Protein	Cytochrome P450 2C9	Homo sapiens	IC50	>	25000.0	nM	PMID[30908048]
NPT213	Individual Protein	Cytochrome P450 2C19	Homo sapiens	IC50	>	25000.0	nM	PMID[30908048]
NPT110	Individual Protein	Cytochrome P450 2D6	Homo sapiens	IC50	=	10000.0	nM	PMID[30908048]
NPT109	Individual Protein	Cytochrome P450 3A4	Homo sapiens	IC50	>	25000.0	nM	PMID[30908048]
NPT81	Cell Line	A549	Homo sapiens	GI50	>	25000.0	nM	PMID[30908048]
NPT401	Cell Line	786-0	Homo sapiens	IC50	>	25000.0	nM	PMID[30908048]
NPT5467	Individual Protein	Protein-tyrosine phosphatase 4A3	Homo sapiens	IC50	=	300.0	nM	PMID[31307888]
NPT71	Cell Line	HEK293	Homo sapiens	CC50	=	670.0	nM	PMID[33479668]
NPT1020	Organism	Pneumocystis carinii	Pneumocystis carinii	Activity	=	27.0	uM	DOI[10.1016/0960-894X(96)00353-8]
NPT1020	Organism	Pneumocystis carinii	Pneumocystis carinii	Activity	=	5.31	uM	DOI[10.1016/0960-894X(96)00353-8]
NPT1018	Organism	Trypanosoma brucei	Trypanosoma brucei	ED50	=	0.008	uM	PMID[11206479]
NPT844	Organism	Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	=	2.2	nM	PMID[14561095]
NPT32	Organism	Mus musculus	Mus musculus	Survival	=	40.8	day	PMID[14561095]
NPT1018	Organism	Trypanosoma brucei	Trypanosoma brucei	ED50	=	0.006	uM	PMID[11405646]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	2000.0	nM	PMID[15027874]
NPT1018	Organism	Trypanosoma brucei	Trypanosoma brucei	IC50	=	13.0	nM	PMID[15027874]
NPT842	Organism	Leishmania mexicana	Leishmania mexicana	IC50	=	1030.0	ug.mL-1	PMID[10509921]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	480.0	ug.mL-1	PMID[10509921]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	450.0	ug.mL-1	PMID[10509921]
NPT1018	Organism	Trypanosoma brucei	Trypanosoma brucei	ED50	=	0.0002	ug ml-1	PMID[11551771]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	1350.0	nM	PMID[13678403]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	2600.0	nM	PMID[12781196]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	9300.0	nM	PMID[12781196]
NPT580	Organism	Trypanosoma cruzi	Trypanosoma cruzi	IC50	=	7100.0	nM	PMID[12781196]
NPT610	Others	Molecular identity unknown		IC50	=	4200.0	nM	PMID[12781196]
NPT27	Others	Unspecified		IC50	=	560.0	nM	PMID[2470903]
NPT317	Uncleic Acid	Nucleic Acid		Ratio	=	6.0	n.a.	PMID[8510102]
NPT844	Organism	Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	=	2.2	nM	PMID[15214792]
NPT32	Organism	Mus musculus	Mus musculus	Survival	=	40.8	day	PMID[15214792]
NPT1018	Organism	Trypanosoma brucei	Trypanosoma brucei	IC50	=	35.0	nM	PMID[11300872]
NPT1208	Organism	Leishmania braziliensis	Leishmania braziliensis	IC50	=	1.3	ug.mL-1	PMID[11514152]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	1.3	ug.mL-1	PMID[11514152]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	1.3	ug.mL-1	PMID[11514152]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.38	mg.kg-1	DOI[10.1016/0960-894X(96)00168-0]
NPT16351	SINGLE PROTEIN	Moloney murine leukaemia virus Pol protein	Moloney murine leukemia virus isolate Shinnick	ID50	=	100.0	ug ml-1	PMID[6157024]
NPT1018	Organism	Trypanosoma brucei	Trypanosoma brucei	Inhibition	=	100.0	%	PMID[10866389]
NPT1018	Organism	Trypanosoma brucei	Trypanosoma brucei	ED50	=	0.01	ug ml-1	PMID[10866368]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Inhibition	=	100.0	%	DOI[10.1016/S0960-894X(97)00086-3]
NPT1496	Protein Complex	Glutamate NMDA receptor	Rattus norvegicus	IC50	=	3060.0	nM	DOI[10.1016/S0960-894X(97)00240-0]
NPT1496	Protein Complex	Glutamate NMDA receptor	Rattus norvegicus	IC50	=	1310.0	nM	DOI[10.1016/S0960-894X(97)00240-0]
NPT1496	Protein Complex	Glutamate NMDA receptor	Rattus norvegicus	IC50	=	1740.0	nM	DOI[10.1016/S0960-894X(97)00240-0]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	820351.54	nM	PMID[9435905]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	1610.0	nM	PMID[12161141]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	2000.0	nM	PMID[12161141]
NPT6	Organism	Plasmodium falciparum	Plasmodium falciparum	IC50	=	15.0	nM	PMID[15115412]
NPT6	Organism	Plasmodium falciparum	Plasmodium falciparum	IC50	=	45.0	nM	PMID[15115412]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	760.0	nM	DOI[10.1016/S0960-894X(97)00166-2]
NPT1018	Organism	Trypanosoma brucei	Trypanosoma brucei	IC50	=	0.8	nM	PMID[12620080]
NPT1018	Organism	Trypanosoma brucei	Trypanosoma brucei	IC50	=	3.1	nM	PMID[12620080]
NPT32	Organism	Mus musculus	Mus musculus	IC50	=	3.2	nM	PMID[12620080]
NPT1018	Organism	Trypanosoma brucei	Trypanosoma brucei	IC50	=	5.0	nM	PMID[12620080]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	EC50	=	1350.0	nM	PMID[14741254]
NPT1496	Protein Complex	Glutamate NMDA receptor	Rattus norvegicus	IC50	=	2590.0	nM	PMID[10340618]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Inhibition	=	97.0	%	PMID[15225696]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Inhibition	=	50.0	%	PMID[15225696]
NPT1020	Organism	Pneumocystis carinii	Pneumocystis carinii	IC50	=	500.0	nM	PMID[15357989]
NPT18217	SINGLE PROTEIN	S-100 protein beta chain	Homo sapiens	Kd	=	1000.0	nM	PMID[15456252]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	IC50	=	1200.0	nM	PMID[15456252]
NPT844	Organism	Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	=	2.3	nM	PMID[16107146]
NPT485	Organism	Plasmodium falciparum (isolate K1 / Thailand)	Plasmodium falciparum K1	IC50	=	34.6	nM	PMID[16107146]
NPT32	Organism	Mus musculus	Mus musculus	Survival	=	40.8	day	PMID[16107146]
NPT32	Organism	Mus musculus	Mus musculus	Survival	>	60.0	day	PMID[16107157]
NPT32	Organism	Mus musculus	Mus musculus	Survival	=	42.75	day	PMID[16107157]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	2500.0	nM	PMID[16509575]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC90	=	8300.0	nM	PMID[16509575]
NPT844	Organism	Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	=	11.0	nM	PMID[16343898]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Inhibition	=	48.0	%	PMID[16503140]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Inhibition	=	71.0	%	PMID[16503140]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	Activity	=	100.0	%	PMID[16722639]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	Activity	=	100.0	%	PMID[16722639]
NPT1208	Organism	Leishmania braziliensis	Leishmania braziliensis	Activity	=	100.0	%	PMID[16722639]
NPT32	Organism	Mus musculus	Mus musculus	Survival	>	42.75	day	PMID[16913722]
NPT844	Organism	Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	=	2.2	nM	PMID[16913722]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	6600.0	nM	PMID[16879965]
NPT844	Organism	Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	ED50	=	0.001	uM	PMID[17004723]
NPT633	Organism	Leishmania donovani	Leishmania donovani	EC50	=	1900000.0	nM	PMID[17116678]
NPT633	Organism	Leishmania donovani	Leishmania donovani	EC50	=	2600000.0	nM	PMID[17116678]
NPT633	Organism	Leishmania donovani	Leishmania donovani	EC50	=	1700000.0	nM	PMID[17116678]
NPT633	Organism	Leishmania donovani	Leishmania donovani	EC50	=	2000000.0	nM	PMID[17116678]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	2000.0	nM	PMID[15588096]
NPT633	Organism	Leishmania donovani	Leishmania donovani	ED50	=	28.9	uM	PMID[16279799]
NPT844	Organism	Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	ED50	=	0.1	nM	PMID[16279799]
NPT580	Organism	Trypanosoma cruzi	Trypanosoma cruzi	ED50	=	4.2	uM	PMID[16279799]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	1.5	ug.mL-1	PMID[17070063]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC90	=	4.9	ug.mL-1	PMID[17070063]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	0.7	ug.mL-1	PMID[17134906]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	1.0	ug.mL-1	PMID[17084633]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC90	=	3.8	ug.mL-1	PMID[17084633]
NPT844	Organism	Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	=	2.8	nM	PMID[17178177]
NPT6	Organism	Plasmodium falciparum	Plasmodium falciparum	IC50	=	58.4	nM	PMID[17178177]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	1.9	nM	PMID[17178177]
NPT580	Organism	Trypanosoma cruzi	Trypanosoma cruzi	IC50	=	5.35	nM	PMID[17178177]
NPT32	Organism	Mus musculus	Mus musculus	Survival	=	40.8	day	PMID[17178177]
NPT1208	Organism	Leishmania braziliensis	Leishmania braziliensis	ED50	=	64.18	uM	PMID[17367894]
NPT1219	Organism	Leishmania chagasi	Leishmania chagasi	ED50	=	27.5	uM	PMID[17367894]
NPT27	Others	Unspecified		TD50	=	2.21	uM	PMID[17367894]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	0.58	ug.mL-1	PMID[17306422]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC90	=	0.88	ug.mL-1	PMID[17306422]
NPT1018	Organism	Trypanosoma brucei	Trypanosoma brucei	IC50	=	4.6	nM	PMID[17197182]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	2300.0	nM	PMID[17618122]
NPT844	Organism	Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	=	3.0	nM	PMID[17948982]
NPT6	Organism	Plasmodium falciparum	Plasmodium falciparum	IC50	=	58.0	nM	PMID[17948982]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	1830.0	nM	PMID[17948982]
NPT2	Others	Unspecified		Ratio IC50	=	15533.0	n.a.	PMID[17948982]
NPT2	Others	Unspecified		Ratio IC50	=	803.0	n.a.	PMID[17948982]
NPT2	Others	Unspecified		Ratio IC50	=	25.0	n.a.	PMID[17948982]
NPT2	Others	Unspecified		Ratio IC50	=	0.05	n.a.	PMID[17948982]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	2.8	ug.mL-1	PMID[17400457]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC90	=	10.0	ug.mL-1	PMID[17400457]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	460.0	nM	PMID[17445951]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Inhibition	=	30.0	%	PMID[17548194]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Inhibition	=	85.0	%	PMID[17548194]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Inhibition	=	90.0	%	PMID[17548194]
NPT6	Organism	Plasmodium falciparum	Plasmodium falciparum	IC50	=	278.0	nM	PMID[17533134]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	IC50	=	2.5	nM	PMID[17880175]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	1300.0	nM	PMID[17880175]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	29400.0	nM	PMID[18024033]
NPT1208	Organism	Leishmania braziliensis	Leishmania braziliensis	IC50	=	29400.0	nM	PMID[18024033]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	29400.0	nM	PMID[18024033]
NPT1018	Organism	Trypanosoma brucei	Trypanosoma brucei	EC50	=	6.0	nM	PMID[18313921]
NPT580	Organism	Trypanosoma cruzi	Trypanosoma cruzi	IC50	=	1100.0	nM	PMID[17339374]
NPT580	Organism	Trypanosoma cruzi	Trypanosoma cruzi	IC90	=	4400.0	nM	PMID[17339374]
NPT844	Organism	Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	=	1200.0	nM	PMID[17339374]
NPT844	Organism	Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC90	=	3700.0	nM	PMID[17339374]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	1000.0	nM	PMID[17339374]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	1.2	ug.mL-1	PMID[17976995]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC90	=	6.0	ug.mL-1	PMID[17976995]
NPT1219	Organism	Leishmania chagasi	Leishmania chagasi	IC50	=	0.1	ug.mL-1	PMID[18177008]
NPT27	Others	Unspecified		IC50	=	8.7	ug.mL-1	PMID[18177008]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	2200.0	nM	PMID[18367395]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC90	=	9800.0	nM	PMID[18367395]
NPT844	Organism	Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	=	50.0	nM	PMID[18367395]
NPT1020	Organism	Pneumocystis carinii	Pneumocystis carinii	IC50	=	500.0	nM	PMID[18367395]
NPT1019	Organism	Trichomonas vaginalis	Trichomonas vaginalis	IC50	=	3815.0	nM	PMID[18486471]
NPT2645	Organism	Giardia intestinalis	Giardia intestinalis	IC50	=	4079.0	nM	PMID[18486471]
NPT992	Organism	Entamoeba histolytica	Entamoeba histolytica	IC50	=	11801.0	nM	PMID[18486471]
NPT842	Organism	Leishmania mexicana	Leishmania mexicana	IC50	=	9568.0	nM	PMID[18486471]
NPT3694	Organism	Leishmania mexicana mexicana	Leishmania mexicana mexicana	IC90	=	1.0	ug	PMID[1919589]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC90	=	1.0	ug	PMID[1919589]
NPT18219	ORGANISM	Leishmania pifanoi	Leishmania pifanoi	IC90	=	1.0	ug	PMID[1919589]
NPT18220	ORGANISM	Leishmania aristidesi	Leishmania aristidesi	IC90	=	1.0	ug	PMID[1919589]
NPT18221	ORGANISM	Leishmania garnhami	Leishmania garnhami	IC90	=	1.0	ug	PMID[1919589]
NPT18222	ORGANISM	Leishmania donovani donovani	Leishmania donovani donovani	IC90	=	1.0	ug	PMID[1919589]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC90	=	1.0	ug	PMID[1919589]
NPT1219	Organism	Leishmania chagasi	Leishmania chagasi	IC90	=	1.0	ug	PMID[1919589]
NPT1208	Organism	Leishmania braziliensis	Leishmania braziliensis	IC90	=	1.0	ug	PMID[1919589]
NPT3631	Organism	Leishmania guyanensis	Leishmania guyanensis	IC90	=	5.0	ug	PMID[1919589]
NPT1596	Organism	Leishmania peruviana	Leishmania peruviana	IC90	=	5.0	ug	PMID[1919589]
NPT18225	ORGANISM	Leishmania mexicana venezuelensis	Leishmania mexicana venezuelensis	IC90	=	5.0	ug	PMID[1919589]
NPT1020	Organism	Pneumocystis carinii	Pneumocystis carinii	Activity	=	2.75	%	PMID[17499888]
NPT1020	Organism	Pneumocystis carinii	Pneumocystis carinii	Activity	=	67.78	%	PMID[17499888]
NPT841	Organism	Leishmania major	Leishmania major	IC50	=	7500.0	nM	PMID[18681480]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	10.0	ug.mL-1	PMID[18712933]
NPT1208	Organism	Leishmania braziliensis	Leishmania braziliensis	IC50	=	10.0	ug.mL-1	PMID[18712933]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	10.0	ug.mL-1	PMID[18712933]
NPT841	Organism	Leishmania major	Leishmania major	IC50	=	4320.0	nM	PMID[18771242]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	IC50	=	0.00158	ug.mL-1	PMID[19013823]
NPT2	Others	Unspecified		Ratio IC50	=	3614.0	n.a.	PMID[19013823]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	Activity	=	100.0	%	PMID[18706738]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	Activity	=	100.0	%	PMID[18706738]
NPT1208	Organism	Leishmania braziliensis	Leishmania braziliensis	Activity	=	100.0	%	PMID[18706738]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	IC50	=	0.0006	ug.mL-1	PMID[12398543]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	0.24	ug.mL-1	PMID[12398543]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	IC50	=	0.0006	ug.mL-1	PMID[12662093]
NPT844	Organism	Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	=	0.0005	ug.mL-1	PMID[12662093]
NPT844	Organism	Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	=	0.004	ug.mL-1	PMID[12662093]
NPT580	Organism	Trypanosoma cruzi	Trypanosoma cruzi	Inhibition	=	100.0	%	PMID[9834160]
NPT1208	Organism	Leishmania braziliensis	Leishmania braziliensis	Inhibition	=	100.0	%	PMID[9834160]
NPT1219	Organism	Leishmania chagasi	Leishmania chagasi	Inhibition	=	100.0	%	PMID[9834160]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	Inhibition	=	100.0	%	PMID[9834160]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	1.6	ug.mL-1	PMID[15165136]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC90	=	3.5	ug.mL-1	PMID[15165136]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	2200.0	nM	PMID[19058972]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	3500.0	nM	PMID[19084416]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC90	=	14700.0	nM	PMID[19084416]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	2.1	ug.mL-1	PMID[18538452]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	2.8	ug.mL-1	PMID[18538452]
NPT27	Others	Unspecified		Activity	>	90.0	ug ml-1	PMID[18538452]
NPT1208	Organism	Leishmania braziliensis	Leishmania braziliensis	IC90	=	1.0	ug.mL-1	DOI[10.1021/np50099a013]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC90	=	1.5	ug.mL-1	PMID[12828466]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	2.1	ug.mL-1	PMID[12828469]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	0.42	ug.mL-1	PMID[12828466]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC90	=	10.0	ug.mL-1	PMID[12828469]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	0.7	ug.mL-1	PMID[12880315]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC90	=	2.4	ug.mL-1	PMID[12880315]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	2.1	ug.mL-1	PMID[15332848]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC90	=	10.0	ug.mL-1	PMID[15332848]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	1060.0	nM	PMID[18571927]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	GI	=	86.0	%	PMID[18558492]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	290.0	nM	PMID[18558492]
NPT844	Organism	Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	=	3.0	nM	PMID[18841956]
NPT2	Others	Unspecified		Ratio IC50	=	15533.0	n.a.	PMID[18841956]
NPT485	Organism	Plasmodium falciparum (isolate K1 / Thailand)	Plasmodium falciparum K1	IC50	=	58.0	nM	PMID[18841956]
NPT2	Others	Unspecified		Ratio IC50	=	803.0	n.a.	PMID[18841956]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	1800.0	nM	PMID[18841956]
NPT2	Others	Unspecified		Ratio IC50	=	25.0	n.a.	PMID[18841956]
NPT844	Organism	Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	Survival	>	57.5	day	PMID[18841956]
NPT844	Organism	Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	Survival	>	45.0	day	PMID[18841956]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	0.643	ug.mL-1	PMID[19328690]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	12.11	ug.mL-1	PMID[19328690]
NPT2	Others	Unspecified		Ratio CC50/IC50	=	2.07	n.a.	PMID[19328690]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	1.6	ug.mL-1	PMID[16643056]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC90	=	6.6	ug.mL-1	PMID[16643056]
NPT841	Organism	Leishmania major	Leishmania major	IC50	=	0.6	ug.mL-1	PMID[16643059]
NPT841	Organism	Leishmania major	Leishmania major	IC90	=	1.9	ug.mL-1	PMID[16643059]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	1.4	ug.mL-1	PMID[15679330]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	IC50	=	0.007	ug.mL-1	PMID[15679330]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	1500.0	nM	PMID[16441066]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	2.1	ug.mL-1	PMID[16872140]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC90	=	10.0	ug.mL-1	PMID[16872140]
NPT1208	Organism	Leishmania braziliensis	Leishmania braziliensis	IC50	=	2900.0	nM	PMID[16499336]
NPT3631	Organism	Leishmania guyanensis	Leishmania guyanensis	IC50	=	900.0	nM	PMID[16499336]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	0.9	ug.mL-1	PMID[18598080]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC90	=	1.8	ug.mL-1	PMID[18598080]
NPT841	Organism	Leishmania major	Leishmania major	FC	=	3.0	n.a.	PMID[17452480]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	FC	=	3.0	n.a.	PMID[17452480]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	FC	=	3.0	n.a.	PMID[17452480]
NPT841	Organism	Leishmania major	Leishmania major	IC50	=	5.1	ug.mL-1	PMID[17452480]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	6.8	ug.mL-1	PMID[17452480]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	10.0	ug.mL-1	PMID[17452480]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	12.11	ug.mL-1	PMID[19091566]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	0.643	ug.mL-1	PMID[19091566]
NPT2	Others	Unspecified		Ratio CC50/IC50	=	2.58	n.a.	PMID[19091566]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Inhibition	=	92.0	%	PMID[19091566]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Inhibition	=	100.0	%	PMID[19091566]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	9800.0	nM	PMID[18192088]
NPT1208	Organism	Leishmania braziliensis	Leishmania braziliensis	IC50	=	9800.0	nM	PMID[18192088]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	9800.0	nM	PMID[18192088]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	900.0	nM	PMID[18192088]
NPT580	Organism	Trypanosoma cruzi	Trypanosoma cruzi	IC50	=	2.4	nM	PMID[17698622]
NPT580	Organism	Trypanosoma cruzi	Trypanosoma cruzi	IC50	=	6.0	nM	PMID[17698622]
NPT580	Organism	Trypanosoma cruzi	Trypanosoma cruzi	Ratio IC50	=	2.5	n.a.	PMID[17698622]
NPT841	Organism	Leishmania major	Leishmania major	IC50	=	3520.0	nM	PMID[17698622]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Activity	=	84.1	%	PMID[19217698]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Activity	=	85.0	%	PMID[19217698]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	12.11	ug.mL-1	PMID[19217698]
NPT2	Others	Unspecified		Ratio CC50/IC50	=	2.58	n.a.	PMID[19217698]
NPT2	Others	Unspecified		Ratio IC50	=	25.0	n.a.	PMID[19606902]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	1800.0	nM	PMID[19606902]
NPT2	Others	Unspecified		Ratio IC50	=	803.0	n.a.	PMID[19606902]
NPT485	Organism	Plasmodium falciparum (isolate K1 / Thailand)	Plasmodium falciparum K1	IC50	=	58.0	nM	PMID[19606902]
NPT2	Others	Unspecified		Ratio IC50	=	15533.0	n.a.	PMID[19606902]
NPT844	Organism	Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	=	3.0	nM	PMID[19606902]
NPT844	Organism	Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	Survival	>	57.5	day	PMID[19606902]
NPT844	Organism	Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	Survival	>	45.0	day	PMID[19606902]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	3800.0	nM	PMID[19344127]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC90	=	19100.0	nM	PMID[19344127]
NPT844	Organism	Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	=	0.4	ug.mL-1	PMID[19159277]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC90	=	2.0	ug.mL-1	PMID[19105653]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	0.5	ug.mL-1	PMID[19105653]
NPT844	Organism	Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	=	3.0	nM	PMID[19757840]
NPT485	Organism	Plasmodium falciparum (isolate K1 / Thailand)	Plasmodium falciparum K1	IC50	=	58.0	nM	PMID[19757840]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	1800.0	nM	PMID[19757840]
NPT2	Others	Unspecified		Ratio IC50	=	25.0	n.a.	PMID[19757840]
NPT2	Others	Unspecified		Ratio IC50	=	803.0	n.a.	PMID[19757840]
NPT2	Others	Unspecified		Ratio IC50	=	15533.0	n.a.	PMID[19757840]
NPT844	Organism	Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	=	2.8	nM	PMID[19409677]
NPT2	Others	Unspecified		Ratio IC50	=	16600.0	n.a.	PMID[19409677]
NPT485	Organism	Plasmodium falciparum (isolate K1 / Thailand)	Plasmodium falciparum K1	IC50	=	46.4	nM	PMID[19409677]
NPT2	Others	Unspecified		Ratio IC50	=	1004.0	n.a.	PMID[19409677]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	1840.0	nM	PMID[19409677]
NPT2	Others	Unspecified		Ratio IC50	=	25.4	n.a.	PMID[19409677]
NPT844	Organism	Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	Survival	=	42.8	day	PMID[19409677]
NPT844	Organism	Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	=	3.0	nM	PMID[19928900]
NPT485	Organism	Plasmodium falciparum (isolate K1 / Thailand)	Plasmodium falciparum K1	IC50	=	58.0	nM	PMID[19928900]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	1800.0	nM	PMID[19928900]
NPT2	Others	Unspecified		Ratio IC50	=	25.0	n.a.	PMID[19928900]
NPT2	Others	Unspecified		Ratio IC50	=	803.0	n.a.	PMID[19928900]
NPT2	Others	Unspecified		Ratio IC50	=	15533.0	n.a.	PMID[19928900]
NPT844	Organism	Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	Activity	=	26.0	day	PMID[19928900]
NPT844	Organism	Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	Activity	=	20.0	day	PMID[19928900]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	12.11	ug.mL-1	PMID[19692240]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Inhibition	=	100.0	%	PMID[19692240]
NPT6	Organism	Plasmodium falciparum	Plasmodium falciparum	EC50	=	68.7	nM	PMID[18579783]
NPT6	Organism	Plasmodium falciparum	Plasmodium falciparum	EC50	=	66.2	nM	PMID[18579783]
NPT844	Organism	Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	Survival	>	38.0	day	PMID[19699098]
NPT844	Organism	Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	Survival	>	57.5	day	PMID[19699098]
NPT2	Others	Unspecified		Ratio IC50	=	0.05	n.a.	PMID[19699098]
NPT485	Organism	Plasmodium falciparum (isolate K1 / Thailand)	Plasmodium falciparum K1	IC50	=	46.4	nM	PMID[19699098]
NPT844	Organism	Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	=	2.2	nM	PMID[19699098]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	12.11	ug.mL-1	PMID[19913413]
NPT2	Others	Unspecified		Ratio CC50/IC50	=	2.58	n.a.	PMID[19913413]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	0.643	ug.mL-1	PMID[19913413]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Inhibition	=	92.0	%	PMID[19913413]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC90	=	6400.0	nM	PMID[19879765]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	2800.0	nM	PMID[19879765]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	6500.0	nM	PMID[20064723]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	0.9	ug.mL-1	PMID[19914074]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC90	=	1.8	ug.mL-1	PMID[19914074]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	EC50	=	670.0	nM	PMID[20004045]
NPT841	Organism	Leishmania major	Leishmania major	EC50	=	3800.0	nM	PMID[20004045]
NPT842	Organism	Leishmania mexicana	Leishmania mexicana	EC50	=	16000.0	nM	PMID[20004045]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	IC50	=	2.0	nM	PMID[19736009]
NPT844	Organism	Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	=	2.0	nM	PMID[19736009]
NPT1020	Organism	Pneumocystis carinii	Pneumocystis carinii	IC50	=	500.0	nM	PMID[19736009]
NPT2	Others	Unspecified		Ratio IC50	=	12000.0	n.a.	PMID[19736009]
NPT2	Others	Unspecified		Ratio IC50	=	48.0	n.a.	PMID[19736009]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	IC50	=	7.0	nM	PMID[20303767]
NPT2	Others	Unspecified		Ratio IC50	=	542.0	n.a.	PMID[20303767]
NPT1208	Organism	Leishmania braziliensis	Leishmania braziliensis	IC50	=	48500.0	nM	PMID[20116908]
NPT844	Organism	Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	=	2.8	nM	PMID[20403703]
NPT485	Organism	Plasmodium falciparum (isolate K1 / Thailand)	Plasmodium falciparum K1	IC50	=	46.4	nM	PMID[20403703]
NPT844	Organism	Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	Survival	=	45.0	day	PMID[20403703]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	IC50	=	2.9	nM	PMID[19715342]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	20430.0	nM	PMID[20371140]
NPT2	Others	Unspecified		Ratio CC50/IC50	=	2.58	n.a.	PMID[20371140]
NPT633	Organism	Leishmania donovani	Leishmania donovani	MIC	>	168710.0	nM	PMID[20371140]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Inhibition	=	85.0	%	PMID[20371140]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	3.23	ug.mL-1	PMID[20199824]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	3.59	ug.mL-1	PMID[20199824]
NPT2	Others	Unspecified		Ratio CC50/IC50	=	1.08	n.a.	PMID[20199824]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Inhibition	=	92.0	%	PMID[20199824]
NPT842	Organism	Leishmania mexicana	Leishmania mexicana	IC50	=	2421.0	nM	PMID[20430484]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	IC50	=	7.0	nM	PMID[20558060]
NPT1020	Organism	Pneumocystis carinii	Pneumocystis carinii	IC50	=	84.0	nM	PMID[20590148]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	12.11	ug.mL-1	PMID[20457476]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Inhibition	=	100.0	%	PMID[20457476]
NPT2	Others	Unspecified		Ratio CC50/IC50	=	2.07	n.a.	PMID[20457476]
NPT6	Organism	Plasmodium falciparum	Plasmodium falciparum	IC50	=	0.0	nM	PMID[20185316]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	1000.0	nM	PMID[20185316]
NPT842	Organism	Leishmania mexicana	Leishmania mexicana	IC50	=	1000.0	nM	PMID[20185316]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	IC50	=	0.0	nM	PMID[20185316]
NPT6	Organism	Plasmodium falciparum	Plasmodium falciparum	IC90	=	6.5	ug.mL-1	PMID[20466465]
NPT6	Organism	Plasmodium falciparum	Plasmodium falciparum	IC50	=	2.9	ug.mL-1	PMID[20466465]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	1.17	ug.mL-1	PMID[20669972]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC90	=	2.45	ug.mL-1	PMID[20669972]
NPT842	Organism	Leishmania mexicana	Leishmania mexicana	IC50	=	13320.0	nM	PMID[20674375]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	11200.0	nM	PMID[20833057]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	EC50	=	822.0	nM	PMID[17417631]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	EC50	=	1995.0	nM	PMID[17417631]
NPT2	Others	Unspecified		Ratio EC50	=	2.43	n.a.	PMID[17417631]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	20430.0	nM	PMID[20850302]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	14000.0	nM	PMID[20368397]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	830.0	nM	PMID[20368397]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	>	50000.0	nM	PMID[20368397]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	1800.0	nM	PMID[20368397]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	IC50	=	3.0	nM	PMID[20850207]
NPT1219	Organism	Leishmania chagasi	Leishmania chagasi	IC50	=	1110.0	nM	PMID[20934347]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	490.0	nM	PMID[20934347]
NPT841	Organism	Leishmania major	Leishmania major	IC50	=	470.0	nM	PMID[20934347]
NPT1208	Organism	Leishmania braziliensis	Leishmania braziliensis	IC50	=	150.0	nM	PMID[20934347]
NPT6	Organism	Plasmodium falciparum	Plasmodium falciparum	IC50	=	12302687.71	nM	PMID[20884090]
NPT6	Organism	Plasmodium falciparum	Plasmodium falciparum	IC50	=	56234132.52	nM	PMID[20884090]
NPT1018	Organism	Trypanosoma brucei	Trypanosoma brucei	EC50	=	0.95	nM	PMID[20439607]
NPT1018	Organism	Trypanosoma brucei	Trypanosoma brucei	EC50	=	2600.0	nM	PMID[20439607]
NPT1018	Organism	Trypanosoma brucei	Trypanosoma brucei	Ratio EC50	=	3.0	n.a.	PMID[20439607]
NPT1018	Organism	Trypanosoma brucei	Trypanosoma brucei	EC50	=	1.7	nM	PMID[20439607]
NPT1018	Organism	Trypanosoma brucei	Trypanosoma brucei	Ratio EC50	=	2.0	n.a.	PMID[20439607]
NPT844	Organism	Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	=	1.3	nM	PMID[21112788]
NPT1018	Organism	Trypanosoma brucei	Trypanosoma brucei	IC50	=	12.0	nM	PMID[21112788]
NPT844	Organism	Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	=	2.2	nM	PMID[21194955]
NPT2	Others	Unspecified		Ratio IC50	=	15533.0	n.a.	PMID[21194955]
NPT485	Organism	Plasmodium falciparum (isolate K1 / Thailand)	Plasmodium falciparum K1	IC50	=	6.4	nM	PMID[21194955]
NPT2	Others	Unspecified		Ratio IC50	=	991.0	n.a.	PMID[21194955]
NPT844	Organism	Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	Survival	>	45.0	day	PMID[21194955]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	1.0	ug.mL-1	PMID[21172735]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC90	=	3.8	ug.mL-1	PMID[21172735]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	Survival	>	40.0	day	PMID[19289530]
NPT602	Organism	Mycobacterium smegmatis	Mycobacterium smegmatis	MIC	=	50000.0	nM	PMID[19786608]
NPT602	Organism	Mycobacterium smegmatis	Mycobacterium smegmatis	IC50	=	11050.0	nM	PMID[19786608]
NPT602	Organism	Mycobacterium smegmatis	Mycobacterium smegmatis	MIC	=	25000.0	nM	PMID[19786608]
NPT602	Organism	Mycobacterium smegmatis	Mycobacterium smegmatis	IC50	=	23530.0	nM	PMID[19786608]
NPT602	Organism	Mycobacterium smegmatis	Mycobacterium smegmatis	IC50	=	9100.0	nM	PMID[19786608]
NPT844	Organism	Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	=	0.0012	ug.mL-1	PMID[19620327]
NPT844	Organism	Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	=	0.1336	ug.mL-1	PMID[19620327]
NPT844	Organism	Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	=	0.1245	ug.mL-1	PMID[19620327]
NPT2229	Organism	Trypanosoma brucei gambiense	Trypanosoma brucei gambiense	IC50	=	0.0155	ug.mL-1	PMID[19620327]
NPT2229	Organism	Trypanosoma brucei gambiense	Trypanosoma brucei gambiense	IC50	=	0.0042	ug.mL-1	PMID[19620327]
NPT2229	Organism	Trypanosoma brucei gambiense	Trypanosoma brucei gambiense	IC50	=	0.0011	ug.mL-1	PMID[19620327]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	IC50	=	0.0009	ug.mL-1	PMID[19620327]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	IC50	=	0.0041	ug.mL-1	PMID[19620327]
NPT844	Organism	Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	Ratio IC50	=	113.1	n.a.	PMID[19620327]
NPT844	Organism	Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	Ratio IC50	=	105.4	n.a.	PMID[19620327]
NPT2	Others	Unspecified		Ratio IC50	=	13.1	n.a.	PMID[19620327]
NPT2	Others	Unspecified		Ratio IC50	=	3.6	n.a.	PMID[19620327]
NPT2	Others	Unspecified		Ratio IC50	=	0.9	n.a.	PMID[19620327]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	Ratio IC50	=	4.3	n.a.	PMID[19620327]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	IC50	=	26.0	nM	PMID[21322634]
NPT841	Organism	Leishmania major	Leishmania major	EC50	=	280.0	nM	PMID[21199921]
NPT841	Organism	Leishmania major	Leishmania major	EC50	=	450.0	nM	PMID[21199921]
NPT841	Organism	Leishmania major	Leishmania major	Ratio EC50	=	1.8	n.a.	PMID[21199921]
NPT844	Organism	Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	Activity	=	24.0	day	PMID[21421317]
NPT2	Others	Unspecified		Ratio IC50	=	991.0	n.a.	PMID[21421317]
NPT485	Organism	Plasmodium falciparum (isolate K1 / Thailand)	Plasmodium falciparum K1	IC50	=	46.4	nM	PMID[21421317]
NPT2	Others	Unspecified		Ratio IC50	=	20909.0	n.a.	PMID[21421317]
NPT844	Organism	Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	=	2.2	nM	PMID[21421317]
NPT844	Organism	Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	=	2.2	nM	PMID[20031421]
NPT485	Organism	Plasmodium falciparum (isolate K1 / Thailand)	Plasmodium falciparum K1	IC50	=	46.4	nM	PMID[20031421]
NPT2	Others	Unspecified		Ratio IC50	=	15533.0	n.a.	PMID[20031421]
NPT2	Others	Unspecified		Ratio IC50	=	991.0	n.a.	PMID[20031421]
NPT2645	Organism	Giardia intestinalis	Giardia intestinalis	IC50	=	4079.0	nM	PMID[21397502]
NPT1019	Organism	Trichomonas vaginalis	Trichomonas vaginalis	IC50	=	3815.0	nM	PMID[21397502]
NPT992	Organism	Entamoeba histolytica	Entamoeba histolytica	IC50	=	11800.0	nM	PMID[21397502]
NPT842	Organism	Leishmania mexicana	Leishmania mexicana	IC50	=	13320.0	nM	PMID[21397502]
NPT580	Organism	Trypanosoma cruzi	Trypanosoma cruzi	IC50	>	50000.0	nM	PMID[21397502]
NPT474	Organism	Plasmodium berghei	Plasmodium berghei	IC50	=	2942.0	nM	PMID[21397502]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	6290.0	nM	PMID[21555166]
NPT2	Others	Unspecified		Ratio IC50	=	0.16	n.a.	PMID[21555166]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	IC50	=	6000.0	nM	PMID[21757358]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	IC50	=	15100.0	nM	PMID[21705225]
NPT844	Organism	Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	=	2.2	nM	PMID[22005186]
NPT485	Organism	Plasmodium falciparum (isolate K1 / Thailand)	Plasmodium falciparum K1	IC50	=	46.4	nM	PMID[22005186]
NPT2	Others	Unspecified		Ratio IC50	=	0.05	n.a.	PMID[22005186]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	10000.0	nM	PMID[22055204]
NPT1208	Organism	Leishmania braziliensis	Leishmania braziliensis	IC50	=	50000.0	nM	PMID[22055204]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	100000.0	nM	PMID[22055204]
NPT27	Others	Unspecified		Activity	=	31.0	%	PMID[22055204]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	2200.0	nM	PMID[22000949]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	1500.0	nM	PMID[22000949]
NPT2	Others	Unspecified		IC50	=	46000.0	nM	PMID[22000949]
NPT633	Organism	Leishmania donovani	Leishmania donovani	EC50	=	3.1	ug.mL-1	PMID[21985060]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	EC50	=	1.4	ug.mL-1	PMID[21985060]
NPT1018	Organism	Trypanosoma brucei	Trypanosoma brucei	EC50	=	8.0	nM	PMID[22264753]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	6200.0	nM	PMID[22248858]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC90	=	3.8	ug.mL-1	PMID[22483965]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	1.0	ug.mL-1	PMID[22483965]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	2840.0	nM	PMID[22472166]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	6600.0	nM	PMID[22472166]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	EC50	=	1.4	nM	PMID[24900279]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	EC50	=	3.2	nM	PMID[24900279]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	EC50	=	66.0	nM	PMID[24900279]
NPT841	Organism	Leishmania major	Leishmania major	EC50	=	4300.0	nM	PMID[24900279]
NPT842	Organism	Leishmania mexicana	Leishmania mexicana	EC50	=	8800.0	nM	PMID[24900279]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	EC50	=	8.0	nM	PMID[22390399]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	EC50	=	9.0	nM	PMID[22390399]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	Ratio EC50	=	1.1	n.a.	PMID[22390399]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	EC50	=	567.0	nM	PMID[22390399]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	Ratio EC50	=	70.9	n.a.	PMID[22390399]
NPT2	Others	Unspecified		Ki	=	36.0	nM	PMID[22390399]
NPT2	Others	Unspecified		Ki	=	56200.0	nM	PMID[22390399]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	6000.0	nM	PMID[22608675]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	8200.0	nM	PMID[22608675]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	>	20000.0	nM	PMID[22608675]
NPT2	Others	Unspecified		Ratio CC50/IC50	=	0.17	n.a.	PMID[22608675]
NPT2	Others	Unspecified		Ratio CC50/IC50	=	0.38	n.a.	PMID[22608675]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	2900.0	nM	PMID[22530813]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC90	=	5580.0	nM	PMID[22530813]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	7000.0	nM	PMID[22559947]
NPT1219	Organism	Leishmania chagasi	Leishmania chagasi	IC50	=	5100.0	nM	PMID[22559947]
NPT2	Others	Unspecified		Ratio IC50	=	3.13	n.a.	PMID[23164660]
NPT841	Organism	Leishmania major	Leishmania major	IC50	=	4800.0	nM	PMID[23164660]
NPT841	Organism	Leishmania major	Leishmania major	Inhibition	=	99.0	%	PMID[23164660]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	54800.0	nM	PMID[22989363]
NPT27	Others	Unspecified		IC50	=	30400.0	nM	PMID[22989363]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	13900.0	nM	PMID[22989363]
NPT27	Others	Unspecified		Ratio IC50	=	5.7	n.a.	PMID[22989363]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	5300.0	nM	PMID[22989363]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Ratio IC50	=	3.9	n.a.	PMID[22989363]
NPT27	Others	Unspecified		Ratio IC50	=	2.2	n.a.	PMID[22989363]
NPT27	Others	Unspecified		Ratio IC50	=	0.6	n.a.	PMID[22989363]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	>	30000.0	nM	PMID[22989363]
NPT27	Others	Unspecified		Ratio IC50	<	1.0	n.a.	PMID[22989363]
NPT2229	Organism	Trypanosoma brucei gambiense	Trypanosoma brucei gambiense	IC50	=	5.2	nM	PMID[23084895]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	IC50	=	3.2	nM	PMID[23084895]
NPT2	Others	Unspecified		Kd	=	40000.0	nM	PMID[23264854]
NPT2	Others	Unspecified		Kd	=	130.0	nM	PMID[23264854]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	1.0	ug.mL-1	PMID[23024574]
NPT633	Organism	Leishmania donovani	Leishmania donovani	EC50	=	1350.0	nM	DOI[10.1007/s00044-006-0142-6]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	Inhibition	=	100.0	%	DOI[10.1007/s00044-011-9654-9]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	EC50	=	460.0	nM	DOI[10.1007/s00044-011-9654-9]
NPT633	Organism	Leishmania donovani	Leishmania donovani	EC50	=	5000.0	nM	DOI[10.1007/s00044-005-0126-y]
NPT1020	Organism	Pneumocystis carinii	Pneumocystis carinii	IC50	=	500.0	nM	DOI[10.1007/s00044-005-0130-2]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC90	=	2.03	ug.mL-1	DOI[10.1007/s00044-013-0572-x]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	1.01	ug.mL-1	DOI[10.1007/s00044-013-0572-x]
NPT27	Others	Unspecified		Activity	>	90.0	ug ml-1	DOI[10.1007/s00044-012-0355-9]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	2.8	ug.mL-1	DOI[10.1007/s00044-012-0355-9]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	2.1	ug.mL-1	DOI[10.1007/s00044-012-0355-9]
NPT2	Others	Unspecified		Ratio IC50	=	56.0	n.a.	PMID[23301592]
NPT6	Organism	Plasmodium falciparum	Plasmodium falciparum	IC50	=	27.0	nM	PMID[23301592]
NPT2	Others	Unspecified		Ratio IC50	=	755.0	n.a.	PMID[23301592]
NPT844	Organism	Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	=	2.0	nM	PMID[23301592]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	20430.0	nM	PMID[23182089]
NPT1018	Organism	Trypanosoma brucei	Trypanosoma brucei	EC50	=	1.1	nM	PMID[23281892]
NPT2	Others	Unspecified		Ratio EC50	=	2.0	n.a.	PMID[23281892]
NPT2	Others	Unspecified		Ratio CC50/IC50	=	2.58	n.a.	PMID[23182089]
NPT2	Others	Unspecified		Ratio	=	0.55	n.a.	PMID[23241029]
NPT2	Others	Unspecified		Ratio	=	0.11	n.a.	PMID[23241029]
NPT2	Others	Unspecified		Ratio	=	0.08	n.a.	PMID[23241029]
NPT2229	Organism	Trypanosoma brucei gambiense	Trypanosoma brucei gambiense	EC50	=	51.0	nM	PMID[23484493]
NPT2229	Organism	Trypanosoma brucei gambiense	Trypanosoma brucei gambiense	EC50	=	0.9	nM	PMID[23484493]
NPT2229	Organism	Trypanosoma brucei gambiense	Trypanosoma brucei gambiense	EC50	=	0.7	nM	PMID[23484493]
NPT844	Organism	Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	EC50	=	0.6	nM	PMID[23484493]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	EC50	=	12.0	nM	PMID[23484493]
NPT18217	SINGLE PROTEIN	S-100 protein beta chain	Homo sapiens	IC50	>	100000.0	nM	PMID[23375094]
NPT18217	SINGLE PROTEIN	S-100 protein beta chain	Homo sapiens	Inhibition	=	14.2	%	PMID[23375094]
NPT1018	Organism	Trypanosoma brucei	Trypanosoma brucei	IC50	=	30.0	nM	PMID[23445522]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	EC50	=	3.5	nM	PMID[23597080]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC90	=	14300.0	nM	PMID[23517732]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC90	=	6210.0	nM	PMID[23517732]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	3290.0	nM	PMID[23517732]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	2900.0	nM	PMID[23517732]
NPT841	Organism	Leishmania major	Leishmania major	IC50	=	5090.0	nM	PMID[23608761]
NPT2	Others	Unspecified		Ratio IC50	=	11436.0	n.a.	PMID[23795673]
NPT2	Others	Unspecified		Ratio IC50	=	1004.0	n.a.	PMID[23795673]
NPT485	Organism	Plasmodium falciparum (isolate K1 / Thailand)	Plasmodium falciparum K1	IC50	=	46.0	nM	PMID[23795673]
NPT844	Organism	Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	=	3.0	nM	PMID[23795673]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	Ratio IC50	=	11.4	n.a.	PMID[23727538]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	IC50	=	5.0	nM	PMID[23727538]
NPT2	Others	Unspecified		Ratio CC50/IC50	=	8.68	n.a.	PMID[23623672]
NPT27	Others	Unspecified		CC50	=	3.82	ug.mL-1	PMID[23623672]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	0.44	ug.mL-1	PMID[23623672]
NPT2229	Organism	Trypanosoma brucei gambiense	Trypanosoma brucei gambiense	IC50	=	11.0	nM	PMID[23902828]
NPT2229	Organism	Trypanosoma brucei gambiense	Trypanosoma brucei gambiense	IC50	=	5.3	nM	PMID[23811085]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	IC50	=	3.2	nM	PMID[23811085]
NPT27	Others	Unspecified		CC50	=	26300.0	nM	PMID[23851117]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	3100.0	nM	PMID[23851117]
NPT27	Others	Unspecified		Activity	=	100.0	%	PMID[23851118]
NPT1219	Organism	Leishmania chagasi	Leishmania chagasi	IC50	=	1760.0	nM	PMID[23851118]
NPT1208	Organism	Leishmania braziliensis	Leishmania braziliensis	IC50	=	1360.0	nM	PMID[23851118]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	1050.0	nM	PMID[23851118]
NPT2	Others	Unspecified		Ratio IC50	=	16643.0	n.a.	PMID[23871911]
NPT2	Others	Unspecified		Ratio IC50	=	1004.0	n.a.	PMID[23871911]
NPT2	Others	Unspecified		Ratio IC50	=	25.0	n.a.	PMID[23871911]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	1840.0	nM	PMID[23871911]
NPT485	Organism	Plasmodium falciparum (isolate K1 / Thailand)	Plasmodium falciparum K1	IC50	=	46.4	nM	PMID[23871911]
NPT844	Organism	Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	=	3.0	nM	PMID[23871911]
NPT18229	ORGANISM	Leishmania tarentolae	Leishmania tarentolae	IC50	=	30.0	nM	PMID[23968432]
NPT2	Others	Unspecified		Ratio CC50/IC50	=	1.96	n.a.	PMID[24125880]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	3380.0	nM	PMID[24125880]
NPT1208	Organism	Leishmania braziliensis	Leishmania braziliensis	IC50	=	13000.0	nM	PMID[24125880]
NPT844	Organism	Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	Survival	>	38.0	day	PMID[24012380]
NPT844	Organism	Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	Survival	>	57.5	day	PMID[24012380]
NPT485	Organism	Plasmodium falciparum (isolate K1 / Thailand)	Plasmodium falciparum K1	IC50	=	46.4	nM	PMID[24012380]
NPT844	Organism	Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	=	2.2	nM	PMID[24012380]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	>	20000.0	nM	PMID[24080103]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	8200.0	nM	PMID[24080103]
NPT2	Others	Unspecified		Ratio CC50/IC50	=	0.4	n.a.	PMID[24080103]
NPT2	Others	Unspecified		Ratio CC50/IC50	=	0.1	n.a.	PMID[24080103]
NPT27	Others	Unspecified		CC50	=	1000.0	nM	PMID[24080103]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	6000.0	nM	PMID[24080103]
NPT2	Others	Unspecified		Ratio CC50/IC50	=	6.27	n.a.	PMID[24900613]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	13680.0	nM	PMID[24900613]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	4.1	nM	PMID[24387625]
NPT2	Others	Unspecified		Ratio IC50	=	3353.0	n.a.	PMID[24388808]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	IC50	=	0.0017	ug.mL-1	PMID[24388808]
NPT2	Others	Unspecified		Ratio IC50	=	1004.0	n.a.	PMID[24268543]
NPT2	Others	Unspecified		Ratio IC50	=	11436.0	n.a.	PMID[24268543]
NPT485	Organism	Plasmodium falciparum (isolate K1 / Thailand)	Plasmodium falciparum K1	IC50	=	46.0	nM	PMID[24268543]
NPT844	Organism	Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	=	3.0	nM	PMID[24268543]
NPT580	Organism	Trypanosoma cruzi	Trypanosoma cruzi	IC50	>	50000.0	nM	PMID[24529307]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	14320.0	nM	PMID[24529307]
NPT1019	Organism	Trichomonas vaginalis	Trichomonas vaginalis	IC50	=	3815.0	nM	PMID[24529307]
NPT2645	Organism	Giardia intestinalis	Giardia intestinalis	IC50	=	4079.0	nM	PMID[24529307]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	EC50	=	1740.0	nM	PMID[24354316]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	16150.0	nM	PMID[24513045]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	IC50	=	11.0	nM	DOI[10.1039/C3MD00065F]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC90	=	6210.0	nM	DOI[10.1039/C3MD00097D]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	3290.0	nM	DOI[10.1039/C3MD00097D]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	IC50	=	11.0	nM	DOI[10.1039/C2MD20197F]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	1.0	ug.mL-1	DOI[10.1039/C0MD00267D]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC90	=	3.8	ug.mL-1	DOI[10.1039/C0MD00267D]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	3820.0	nM	DOI[10.1039/C2MD20143G]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC90	=	12400.0	nM	DOI[10.1039/C2MD20143G]
NPT1018	Organism	Trypanosoma brucei	Trypanosoma brucei	IC50	=	6430.0	nM	PMID[24630563]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	Ratio IC50	=	24.84	n.a.	PMID[24630563]
NPT580	Organism	Trypanosoma cruzi	Trypanosoma cruzi	IC50	=	4580.0	nM	PMID[24630563]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	Ratio IC50	=	34.87	n.a.	PMID[24630563]
NPT3929	Protein Complex	Glutamate NMDA receptor; GRIN1/GRIN2A	Homo sapiens	IC50	=	720.0	nM	PMID[24630693]
NPT2	Others	Unspecified		IC50	=	38000.0	nM	PMID[24630693]
NPT23192	SINGLE PROTEIN	Acid-sensing ion channel 1	Mus musculus	Inhibition	=	39.0	%	PMID[24630693]
NPT23192	SINGLE PROTEIN	Acid-sensing ion channel 1	Mus musculus	Inhibition	=	92.0	%	PMID[24630693]
NPT18231	SINGLE PROTEIN	Acid-sensing ion channel 2	Mus musculus	Inhibition	=	51.0	%	PMID[24630693]
NPT18232	SINGLE PROTEIN	Acid-sensing ion channel 3	Mus musculus	Inhibition	=	74.0	%	PMID[24630693]
NPT2	Others	Unspecified		Inhibition	=	48.2	%	PMID[24630693]
NPT2	Others	Unspecified		Inhibition	=	10.8	%	PMID[24630693]
NPT26459	SINGLE PROTEIN	Diamine oxidase	Homo sapiens	Ki	=	290.0	nM	PMID[24630693]
NPT2	Others	Unspecified		Ki	=	7600.0	nM	PMID[24630693]
NPT25986	SINGLE PROTEIN	Spermidine/spermine N(1)-acetyltransferase 1	Homo sapiens	Ki	=	2000.0	nM	PMID[24630693]
NPT2	Others	Unspecified		IC50	>	1000000.0	nM	PMID[24630693]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	IC50	=	1200.0	nM	PMID[24630693]
NPT18234	SINGLE PROTEIN	Acrosin	Sus scrofa	Ki	=	2300.0	nM	PMID[722718]
NPT841	Organism	Leishmania major	Leishmania major	IC50	=	4300.0	nM	PMID[24858543]
NPT842	Organism	Leishmania mexicana	Leishmania mexicana	IC50	=	2400.0	nM	PMID[24858543]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	5500.0	nM	PMID[24858543]
NPT27	Others	Unspecified		CC50	=	560.0	nM	PMID[24858543]
NPT2	Others	Unspecified		Ratio CC50/IC50	=	0.5	n.a.	PMID[24858543]
NPT2	Others	Unspecified		Ratio CC50/IC50	=	1.0	n.a.	PMID[24858543]
NPT2	Others	Unspecified		Ratio CC50/IC50	=	0.4	n.a.	PMID[24858543]
NPT2	Others	Unspecified		Ratio CC50/IC50	=	0.1	n.a.	PMID[24858543]
NPT2	Others	Unspecified		Ratio CC50/IC50	=	0.2	n.a.	PMID[24858543]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	IC50	=	50.0	nM	PMID[24858543]
NPT2	Others	Unspecified		Ratio CC50/IC50	=	46.0	n.a.	PMID[24858543]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	IC50	=	26.0	nM	PMID[24826816]
NPT580	Organism	Trypanosoma cruzi	Trypanosoma cruzi	IC50	=	7100.0	nM	PMID[24956553]
NPT2	Others	Unspecified		Ratio IC50	=	6.53	n.a.	PMID[24956553]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	830.0	nM	PMID[24956553]
NPT2	Others	Unspecified		Ratio IC50	=	55.9	n.a.	PMID[24956553]
NPT844	Organism	Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	=	2.3	nM	PMID[24956553]
NPT485	Organism	Plasmodium falciparum (isolate K1 / Thailand)	Plasmodium falciparum K1	IC50	=	46.4	nM	PMID[24956553]
NPT2	Others	Unspecified		Ratio IC50	=	1004.0	n.a.	PMID[24956553]
NPT2	Others	Unspecified		Ratio IC50	=	20173.0	n.a.	PMID[24956553]
NPT1018	Organism	Trypanosoma brucei	Trypanosoma brucei	IC50	=	11.0	nM	PMID[25499437]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	4210.0	nM	PMID[25499437]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	Activity	=	100.0	%	PMID[24978605]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	Activity	=	58.1	%	PMID[24978605]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	4800.0	nM	PMID[24980054]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC90	=	6100.0	nM	PMID[24980054]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	>	29400.0	nM	PMID[24980054]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC90	>	29400.0	nM	PMID[24980054]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	2000.0	nM	PMID[24980054]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC90	=	3100.0	nM	PMID[24980054]
NPT1018	Organism	Trypanosoma brucei	Trypanosoma brucei	IC50	=	4.1	nM	PMID[24980054]
NPT1018	Organism	Trypanosoma brucei	Trypanosoma brucei	IC90	=	7.0	nM	PMID[24980054]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	3200.0	nM	PMID[25084548]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC90	=	5900.0	nM	PMID[25084548]
NPT841	Organism	Leishmania major	Leishmania major	IC50	=	7020.0	nM	PMID[25069019]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	EC50	=	5.3	ug.mL-1	PMID[25281268]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	0.6	ug.mL-1	PMID[25240614]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	8.9	ug.mL-1	PMID[25240614]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	0.4	ug.mL-1	PMID[25240614]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	5520.0	nM	PMID[25282267]
NPT27	Others	Unspecified		CC50	=	560.0	nM	PMID[25282267]
NPT2	Others	Unspecified		Ratio CC50/IC50	=	0.1	n.a.	PMID[25282267]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	2630.0	nM	DOI[10.6019/CHEMBL3392926]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	IC50	=	8870.0	nM	DOI[10.6019/CHEMBL3392926]
NPT844	Organism	Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	=	10.0	nM	DOI[10.6019/CHEMBL3392926]
NPT580	Organism	Trypanosoma cruzi	Trypanosoma cruzi	IC50	=	4440.0	nM	DOI[10.6019/CHEMBL3392926]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	19770.0	nM	DOI[10.6019/CHEMBL3392926]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	IC50	>	29370.0	nM	DOI[10.6019/CHEMBL3392926]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	IC50	=	7780.0	nM	DOI[10.6019/CHEMBL3392926]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	6000.0	nM	PMID[25846065]
NPT2	Others	Unspecified		Ratio CC50/IC50	=	0.4	n.a.	PMID[25846065]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	>	20000.0	nM	PMID[25846065]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	>	20000.0	nM	PMID[25846065]
NPT27	Others	Unspecified		IC50	=	1000.0	nM	PMID[25846065]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	6000.0	nM	PMID[25559208]
NPT2	Others	Unspecified		Ratio CC50/IC50	=	0.4	n.a.	PMID[25559208]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	>	20000.0	nM	PMID[25559208]
NPT2	Others	Unspecified		IC50	=	400000.0	nM	PMID[25574764]
NPT2	Others	Unspecified		IC50	=	240000.0	nM	PMID[25574764]
NPT1466	Organism	Escherichia coli K12	Escherichia coli K-12	EC50	=	12000.0	nM	PMID[25574764]
NPT16	Organism	Staphylococcus aureus	Staphylococcus aureus	EC50	=	4200.0	nM	PMID[25574764]
NPT2229	Organism	Trypanosoma brucei gambiense	Trypanosoma brucei gambiense	IC50	=	7.0	nM	PMID[25659770]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	Ratio EC50	=	32.9	n.a.	PMID[25699142]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	EC50	=	329.0	nM	PMID[25699142]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	Ratio EC50	=	0.6	n.a.	PMID[25699142]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	EC50	=	6.0	nM	PMID[25699142]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	EC50	=	10.0	nM	PMID[25699142]
NPT20	Organism	Candida albicans	Candida albicans	MIC	=	25.0	ug.mL-1	PMID[26209266]
NPT187	Organism	Issatchenkia orientalis	Pichia kudriavzevii	MIC	=	19.8	ug.mL-1	PMID[26209266]
NPT2229	Organism	Trypanosoma brucei gambiense	Trypanosoma brucei gambiense	IC50	=	4.9	nM	PMID[25835356]
NPT554	Organism	Candida glabrata	Candida glabrata	MIC	=	3.13	ug.mL-1	PMID[26209266]
NPT188	Organism	Candida parapsilosis	Candida parapsilosis	MIC	=	12.5	ug.mL-1	PMID[26209266]
NPT85	Organism	Filobasidiella neoformans	Cryptococcus neoformans	MIC	>=	100.0	ug.mL-1	PMID[26209266]
NPT20	Organism	Candida albicans	Candida albicans	IC50	=	0.19	ug.mL-1	PMID[26209266]
NPT20	Organism	Candida albicans	Candida albicans	IC50	=	12.2	ug.mL-1	PMID[26209266]
NPT20	Organism	Candida albicans	Candida albicans	IC50	>	25.0	ug.mL-1	PMID[26209266]
NPT2	Others	Unspecified		Ratio EC50	=	3.5	n.a.	PMID[26055530]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	EC50	=	10190.0	nM	PMID[26055530]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	EC50	=	6250.0	nM	PMID[26055530]
NPT2	Others	Unspecified		Ratio EC50	=	5.71	n.a.	PMID[26055530]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	EC50	=	67710.0	nM	PMID[26055530]
NPT2	Others	Unspecified		Ratio EC50	=	0.53	n.a.	PMID[26055530]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	EC50	=	19770.0	nM	PMID[26055530]
NPT2	Others	Unspecified		Ratio EC50	=	1.81	n.a.	PMID[26055530]
NPT27	Others	Unspecified		EC50	=	35690.0	nM	PMID[26055530]
NPT27	Others	Unspecified		CC50	=	35700.0	nM	PMID[26169126]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	6700.0	nM	PMID[26169126]
NPT2	Others	Unspecified		Ratio CC50/IC50	=	5.3	n.a.	PMID[26169126]
NPT1208	Organism	Leishmania braziliensis	Leishmania braziliensis	IC50	=	60.0	nM	PMID[26107111]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	1800.0	nM	PMID[26107111]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	6620.0	nM	PMID[26112378]
NPT27	Others	Unspecified		CC50	=	11220.0	nM	PMID[26112378]
NPT2	Others	Unspecified		Ratio CC50/IC50	=	1.69	n.a.	PMID[26112378]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	Ratio EC50	=	3349.0	n.a.	PMID[26231081]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	EC50	=	550.0	nM	PMID[26231081]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	EC50	=	0.11	nM	PMID[26231081]
NPT1496	Protein Complex	Glutamate NMDA receptor	Rattus norvegicus	Ratio IC50	=	1.51	n.a.	PMID[26296478]
NPT1496	Protein Complex	Glutamate NMDA receptor	Rattus norvegicus	Ratio IC50	=	9.12	n.a.	PMID[26296478]
NPT1496	Protein Complex	Glutamate NMDA receptor	Rattus norvegicus	IC50	=	3050.0	nM	PMID[26296478]
NPT1496	Protein Complex	Glutamate NMDA receptor	Rattus norvegicus	Ratio IC50	=	3.82	n.a.	PMID[26296478]
NPT1496	Protein Complex	Glutamate NMDA receptor	Rattus norvegicus	Ratio IC50	=	6.69	n.a.	PMID[26296478]
NPT1496	Protein Complex	Glutamate NMDA receptor	Rattus norvegicus	Ratio IC50	=	5.86	n.a.	PMID[26296478]
NPT1496	Protein Complex	Glutamate NMDA receptor	Rattus norvegicus	Ratio IC50	=	3.27	n.a.	PMID[26296478]
NPT1496	Protein Complex	Glutamate NMDA receptor	Rattus norvegicus	Ratio IC50	=	3.07	n.a.	PMID[26296478]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	IC50	=	1.6	nM	PMID[26322631]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	4800.0	nM	PMID[26375353]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	1900.0	nM	PMID[26375353]
NPT27	Others	Unspecified		LD50	=	8.5	uM	PMID[26375353]
NPT841	Organism	Leishmania major	Leishmania major	IC50	=	4600.0	nM	PMID[26383125]
NPT841	Organism	Leishmania major	Leishmania major	IC50	=	3000.0	nM	PMID[26383125]
NPT27	Others	Unspecified		IC50	=	152700.0	nM	PMID[26383125]
NPT27	Others	Unspecified		Ratio IC50	=	33.2	n.a.	PMID[26383125]
NPT27	Others	Unspecified		Ratio IC50	=	50.9	n.a.	PMID[26383125]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	1.885	ug.mL-1	PMID[26520665]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC90	=	5.81	ug.mL-1	PMID[26520665]
NPT1018	Organism	Trypanosoma brucei	Trypanosoma brucei	IC50	=	0.002	ug.mL-1	PMID[26520665]
NPT1018	Organism	Trypanosoma brucei	Trypanosoma brucei	IC90	=	0.003	ug.mL-1	PMID[26520665]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	5.5	ug.mL-1	PMID[26778149]
NPT841	Organism	Leishmania major	Leishmania major	IC50	=	5090.0	nM	PMID[26619389]
NPT18235	SINGLE PROTEIN	Protein S100-B	Rattus norvegicus	Kd	=	44000.0	nM	PMID[26727270]
NPT18235	SINGLE PROTEIN	Protein S100-B	Rattus norvegicus	Kd	=	50000.0	nM	PMID[26727270]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	EC50	=	16700.0	nM	PMID[26727270]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	EC50	=	16300.0	nM	PMID[26727270]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	IC50	=	11.0	nM	PMID[26774924]
NPT2	Others	Unspecified		Ratio IC50	=	11400.0	n.a.	PMID[27102161]
NPT844	Organism	Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	=	2800.0	nM	PMID[27102161]
NPT21772	PROTEIN COMPLEX	GroEL/GroES	Escherichia coli	IC50	>	100000.0	nM	PMID[27720295]
NPT21772	PROTEIN COMPLEX	GroEL/GroES	Escherichia coli	IC50	>	250000.0	nM	PMID[27720295]
NPT21774	PROTEIN COMPLEX	HSP60/HSP10	Homo sapiens	IC50	>	100000.0	nM	PMID[27720295]
NPT21774	PROTEIN COMPLEX	HSP60/HSP10	Homo sapiens	IC50	>	250000.0	nM	PMID[27720295]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	EC50	<	19.0	nM	PMID[27720295]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	EC50	=	19000.0	nM	PMID[27720295]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	EC50	>	100000.0	nM	PMID[27720295]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	IC50	>	63000.0	nM	PMID[27720295]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	IC50	=	2.1	nM	PMID[27793448]
NPT32	Organism	Mus musculus	Mus musculus	CC50	>	100000.0	nM	PMID[27793448]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	EC50	=	0.9	nM	PMID[27788467]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	EC50	=	1.55	nM	PMID[28064141]
NPT98	Individual Protein	HERG	Homo sapiens	IC50	=	18800.0	nM	PMID[28064141]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	EC50	=	2.8	nM	PMID[28112515]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	EC50	=	940.0	nM	PMID[28112515]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	EC50	=	4.0	nM	PMID[28112515]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	Ratio EC50	=	1.32	n.a.	PMID[28112515]
NPT2	Others	Unspecified		Ratio EC50	=	98.0	n.a.	PMID[28112515]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	16150.0	nM	PMID[28003139]
NPT841	Organism	Leishmania major	Leishmania major	IC50	=	7020.0	nM	PMID[28012342]
NPT2	Others	Unspecified		Ratio IC50	=	1.1	n.a.	PMID[28012342]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	EC50	=	2.1	nM	PMID[28187957]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	IC50	=	5.0	nM	PMID[27912173]
NPT844	Organism	Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	=	11.0	nM	PMID[28189085]
NPT1799	Organism	Leishmania	Leishmania	Activity	=	90.0	%	PMID[28161253]
NPT713	Individual Protein	Bile salt export pump	Homo sapiens	IC50	>	135000.0	nM	PMID[20829430]
NPT713	Individual Protein	Bile salt export pump	Homo sapiens	IC50	>	1000000.0	nM	PMID[22961681]
NPT1018	Organism	Trypanosoma brucei	Trypanosoma brucei	EC50	=	938.0	nM	PMID[28571825]
NPT1018	Organism	Trypanosoma brucei	Trypanosoma brucei	EC50	=	5.7	nM	PMID[28571825]
NPT1018	Organism	Trypanosoma brucei	Trypanosoma brucei	EC50	=	5.1	nM	PMID[28571825]
NPT1018	Organism	Trypanosoma brucei	Trypanosoma brucei	EC50	=	6.1	nM	PMID[28571825]
NPT1018	Organism	Trypanosoma brucei	Trypanosoma brucei	Ratio EC50	=	164.0	n.a.	PMID[28571825]
NPT1018	Organism	Trypanosoma brucei	Trypanosoma brucei	Ratio EC50	=	0.89	n.a.	PMID[28571825]
NPT1018	Organism	Trypanosoma brucei	Trypanosoma brucei	Ratio EC50	=	1.06	n.a.	PMID[28571825]
NPT842	Organism	Leishmania mexicana	Leishmania mexicana	EC50	=	1900.0	nM	PMID[28571825]
NPT842	Organism	Leishmania mexicana	Leishmania mexicana	EC50	=	1630.0	nM	PMID[28571825]
NPT842	Organism	Leishmania mexicana	Leishmania mexicana	Ratio EC50	=	0.86	n.a.	PMID[28571825]
NPT713	Individual Protein	Bile salt export pump	Homo sapiens	IC50	>	133000.0	nM	PMID[23956101]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	EC50	=	2.16	nM	PMID[28740614]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	EC90	=	0.00613	uM	PMID[28740614]
NPT844	Organism	Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	=	9.0	nM	PMID[29590751]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	100.0	ug.mL-1	PMID[28383902]
NPT2645	Organism	Giardia intestinalis	Giardia intestinalis	IC50	=	4079.0	nM	PMID[28645659]
NPT1019	Organism	Trichomonas vaginalis	Trichomonas vaginalis	IC50	=	3815.0	nM	PMID[28645659]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	14320.0	nM	PMID[28645659]
NPT842	Organism	Leishmania mexicana	Leishmania mexicana	IC50	=	13320.0	nM	PMID[28645659]
NPT580	Organism	Trypanosoma cruzi	Trypanosoma cruzi	IC50	>	50000.0	nM	PMID[28645659]
NPT2	Others	Unspecified		Ratio CC50/IC50	=	11.0	n.a.	PMID[28645659]
NPT2	Others	Unspecified		Ratio CC50/IC50	=	12.3	n.a.	PMID[28645659]
NPT2	Others	Unspecified		Ratio CC50/IC50	=	3.2	n.a.	PMID[28645659]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	IC50	=	5.3	nM	PMID[28698054]
NPT20763	CELL-LINE	J774.1	Mus musculus	IC50	=	38600.0	nM	PMID[28698054]
NPT2	Others	Unspecified		Ratio IC50	=	7283.0	n.a.	PMID[28698054]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	4200.0	nM	PMID[29407957]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	1800.0	nM	PMID[29407957]
NPT21752	CELL-LINE	Peritoneal macrophage cells	n.a.	LD50	=	8.5	umol/L	PMID[29407957]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	10000.0	nM	PMID[28988624]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	21.0	nM	PMID[28988624]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	62.0	nM	PMID[28988624]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	Activity	=	100.0	%	PMID[29191556]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	16.15	ug.mL-1	PMID[29258770]
NPT1018	Organism	Trypanosoma brucei	Trypanosoma brucei	EC50	=	1.6	nM	PMID[29407968]
NPT1018	Organism	Trypanosoma brucei	Trypanosoma brucei	EC50	=	3.8	nM	PMID[29407968]
NPT98	Individual Protein	HERG	Homo sapiens	IC50	=	18700.0	nM	PMID[29407968]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	5700.0	nM	PMID[29459275]
NPT21752	CELL-LINE	Peritoneal macrophage cells	n.a.	CC50	=	8500.0	nM	PMID[29459275]
NPT2	Others	Unspecified		Ratio CC50/IC50	=	1.5	n.a.	PMID[29459275]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	1900.0	nM	PMID[29459275]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	EC50	=	8310.0	nM	PMID[29549840]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	EC50	=	2700.0	nM	PMID[29549840]
NPT633	Organism	Leishmania donovani	Leishmania donovani	EC50	=	6400.0	nM	PMID[29549840]
NPT633	Organism	Leishmania donovani	Leishmania donovani	EC50	=	1600.0	nM	PMID[29549840]
NPT633	Organism	Leishmania donovani	Leishmania donovani	EC50	=	23700.0	nM	PMID[29549840]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	EC50	=	4.2	nM	PMID[30258542]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	9000.0	nM	PMID[30298736]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC90	=	17000.0	nM	PMID[30298736]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	EC50	=	3.3	nM	PMID[29544150]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	EC50	=	4.0	nM	PMID[29544150]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	Ratio EC50	=	1.14	n.a.	PMID[29544150]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	EC50	=	47.0	nM	PMID[29544150]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	EC50	=	64.0	nM	PMID[29544150]
NPT1018	Organism	Trypanosoma brucei	Trypanosoma brucei	EC50	=	940.0	nM	PMID[29544150]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	Ratio EC50	=	14.1	n.a.	PMID[29544150]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	Ratio EC50	=	19.2	n.a.	PMID[29544150]
NPT2	Others	Unspecified		Ratio EC50	=	285.0	n.a.	PMID[29544150]
NPT1018	Organism	Trypanosoma brucei	Trypanosoma brucei	IC50	=	10.0	nM	PMID[30100019]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	1.0	ug.mL-1	PMID[29232588]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC90	=	2.0	ug.mL-1	PMID[29232588]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	6200.0	nM	PMID[28993794]
NPT2	Others	Unspecified		IC50	=	33800.0	nM	PMID[30108719]
NPT1020	Organism	Pneumocystis carinii	Pneumocystis carinii	IC50	=	500.0	nM	PMID[30108719]
NPT841	Organism	Leishmania major	Leishmania major	IC50	=	14950.0	nM	PMID[30146096]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	IC50	=	26.0	nM	PMID[31732256]
NPT21752	CELL-LINE	Peritoneal macrophage cells	n.a.	LC50	=	17200.0	nM	PMID[31176565]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	EC50	=	800.0	nM	PMID[31176565]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	3100.0	nM	PMID[31732409]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	7600.0	nM	PMID[30913526]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	5070.0	nM	PMID[30913526]
NPT21752	CELL-LINE	Peritoneal macrophage cells	n.a.	CC50	=	35700.0	nM	PMID[30913526]
NPT27	Others	Unspecified		Ratio CC50/IC50	=	4.7	n.a.	PMID[30913526]
NPT27	Others	Unspecified		Ratio CC50/IC50	=	7.0	n.a.	PMID[30913526]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	Activity	=	81.0	%	PMID[30913526]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	IC50	=	3.1	nM	PMID[30647879]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	IC50	=	2.0	nM	PMID[30468386]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	IC50	=	1.995	nM	PMID[30468386]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	6000.0	nM	PMID[30655943]
NPT2	Others	Unspecified		Ratio CC50/IC50	=	0.4	n.a.	PMID[30655943]
NPT1018	Organism	Trypanosoma brucei	Trypanosoma brucei	EC50	=	1420.0	nM	PMID[30655955]
NPT98	Individual Protein	HERG	Homo sapiens	IC50	=	10000.0	nM	PMID[30908048]
NPT1018	Organism	Trypanosoma brucei	Trypanosoma brucei	EC50	=	3.8	nM	PMID[30908048]
NPT2	Others	Unspecified		Ratio IC50	=	5396.0	n.a.	PMID[31051403]
NPT2	Others	Unspecified		IC50	=	23200.0	nM	PMID[31051403]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	IC50	=	1.4	nM	PMID[31051403]
NPT2229	Organism	Trypanosoma brucei gambiense	Trypanosoma brucei gambiense	IC50	=	1.5	nM	PMID[31051403]
NPT1018	Organism	Trypanosoma brucei	Trypanosoma brucei	EC50	=	11.0	nM	PMID[30677668]
NPT1018	Organism	Trypanosoma brucei	Trypanosoma brucei	EC50	=	18.0	nM	PMID[30677668]
NPT1018	Organism	Trypanosoma brucei	Trypanosoma brucei	EC50	=	990.0	nM	PMID[30677668]
NPT1018	Organism	Trypanosoma brucei	Trypanosoma brucei	EC50	=	140.0	nM	PMID[30677668]
NPT1018	Organism	Trypanosoma brucei	Trypanosoma brucei	Ratio EC50	=	1.8	n.a.	PMID[30677668]
NPT1018	Organism	Trypanosoma brucei	Trypanosoma brucei	Ratio EC50	=	94.6	n.a.	PMID[30677668]
NPT1018	Organism	Trypanosoma brucei	Trypanosoma brucei	Ratio EC50	=	13.8	n.a.	PMID[30677668]
NPT25810	ORGANISM	Trypanosoma congolense	Trypanosoma congolense	EC50	=	1900.0	nM	PMID[30677668]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	EC50	=	1.55	nM	PMID[27411733]
NPT2	Others	Unspecified		Ratio CC50/EC50	=	6440.0	n.a.	PMID[27411733]
NPT1018	Organism	Trypanosoma brucei	Trypanosoma brucei	IC50	=	1.55	nM	PMID[30996791]
NPT18239	SINGLE PROTEIN	Protein tyrosine phosphatase type IVA 1	Homo sapiens	IC50	=	300.0	nM	PMID[31307888]
NPT18240	SINGLE PROTEIN	Protein tyrosine phosphatase type IVA 2	Homo sapiens	IC50	=	300.0	nM	PMID[31307888]
NPT2229	Organism	Trypanosoma brucei gambiense	Trypanosoma brucei gambiense	IC50	=	1.0	nM	PMID[30774852]
NPT22194	ORGANISM	Naegleria gruberi	Naegleria gruberi	Inhibition	n.a.	43.0	%	DOI[10.6019/CHEMBL4513101]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	IC50	=	39.0	nM	PMID[31952962]
NPT20555	ORGANISM	SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2	IC50	>	20000.0	nM	DOI[10.6019/CHEMBL4651402]
NPT20555	ORGANISM	SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2	IC50	>	19952.62	nM	DOI[10.6019/CHEMBL4651402]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	IC50	=	2.13	nM	PMID[34095848]
NPT2	Others	Unspecified		Ratio IC50	=	307.0	n.a.	PMID[34095848]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	4400.0	nM	PMID[34046604]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	EC50	=	11.0	nM	PMID[31931339]
NPT1018	Organism	Trypanosoma brucei	Trypanosoma brucei	EC50	=	18.0	nM	PMID[31931339]
NPT2	Others	Unspecified		Ratio EC50	=	1.8	n.a.	PMID[31931339]
NPT1018	Organism	Trypanosoma brucei	Trypanosoma brucei	EC50	=	990.0	nM	PMID[31931339]
NPT2	Others	Unspecified		Ratio EC50	=	94.6	n.a.	PMID[31931339]
NPT1018	Organism	Trypanosoma brucei	Trypanosoma brucei	EC50	=	140.0	nM	PMID[31931339]
NPT2	Others	Unspecified		Ratio EC50	=	13.8	n.a.	PMID[31931339]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	EC50	=	1.7	nM	PMID[33479683]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	IC50	=	14.0	nM	PMID[33479668]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	2790.0	nM	PMID[32795626]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC90	=	5290.0	nM	PMID[32795626]
NPT2	Others	Unspecified		IC50	=	9100.0	nM	PMID[33550183]

☑ Note for Activity Records:
☉ The quantitative biological activities were primarily integrated from ChEMBL (Version-30) database and were also directly collected from PubMed literature. PubMed PMID was provided as the reference link for each activity record.

Chemically structural similarity: I. Similar Active Natural Products in NPASS

Top-200 similar NPs were calculated against the active-NP-set (includes 4,3285 NPs with experimentally-derived bioactivity available in NPASS)

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient

● The left chart: Distribution of similarity level between NPC53494 and all remaining natural products in the NPASS database.
● The right table: Most similar natural products (Tc>=0.56 or Top200).

range	Tanimoto Coefficient
0-0.1	259
0.1-0.2	3254
0.2-0.3	12925
0.3-0.4	4463
0.4-0.5	9517
0.5-0.6	10521
0.6-0.7	1704
0.7-0.8	53
0.8-0.85	0
0.85-0.9	0
0.9-0.95	0
0.95-1	1

Similarity Score	Similarity Level	Natural Product ID

Chemically structural similarity: II. Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

● The left chart: Distribution of similarity level between NPC53494 and all drugs/candidates.
● The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).

range	Tanimoto Coefficient
0-0.1	186
0.1-0.2	889
0.2-0.3	1028
0.3-0.4	2079
0.4-0.5	2846
0.5-0.6	1602
0.6-0.7	472
0.7-0.8	44
0.8-0.85	0
0.85-0.9	2
0.9-0.95	0
0.95-1	2

Similarity Score	Similarity Level	Drug ID	Developmental Stage

Bioactivity similarity: Similar Natural Products in NPASS

Bioactivity similarity was calculated based on bioactivity descriptors of compounds. The bioactivity descriptors were calculated by a recently developed AI algorithm Chemical Checker (CC) [Nature Biotechnology, 38:1087–1096, 2020; Nature Communications, 12:3932, 2021], which evaluated bioactivity similarities at five levels:
☉ A: chemistry similarity;
☉ B: biological targets similarity;
☉ C: networks similarity;
☉ D: cell-based bioactivity similarity;
☉ E: similarity based on clinical data.

Those 5 categories of CC bioactivity descriptors were calculated and then subjected to manifold projection using UMAP algorithm, to project all NPs on a 2-Dimensional space. The current NP was highlighted with a small circle in the 2-D map. Below figures: left-to-right, A-to-E.

A: chemistry similarity

B: biological targets similarity

C: networks similarity

D: cell-based bioactivity similarity

E: similarity based on clinical data