NPASS Compound

Structure

Physi-Chem Properties

Molecular Weight:	198.12
Volume:	216.546
LogP:	2.813
LogD:	2.534
LogS:	-2.967
# Rotatable Bonds:	0
TPSA:	39.64
# H-Bond Aceptor:	2
# H-Bond Donor:	2
# Rings:	3
# Heavy Atoms:	2

MedChem Properties

QED Drug-Likeness Score:	0.653
Synthetic Accessibility Score:	2.536
Fsp3:	0.308
Lipinski Rule-of-5:	Accepted
Pfizer Rule:	Accepted
GSK Rule:	Accepted
BMS Rule:	0
Golden Triangle Rule:	Rejected
Chelating Alert:	0
PAINS Alert:	0

ADMET Properties (ADMETlab2.0)

ADMET: Absorption

Caco-2 Permeability:	-4.953
MDCK Permeability:	2.0277924704714678e-05
Pgp-inhibitor:	0.001
Pgp-substrate:	0.989
Human Intestinal Absorption (HIA):	0.043
20% Bioavailability (F20%):	0.955
30% Bioavailability (F30%):	0.989

ADMET: Distribution

Blood-Brain-Barrier Penetration (BBB):	0.991
Plasma Protein Binding (PPB):	73.8930892944336%
Volume Distribution (VD):	2.105
Pgp-substrate:	13.548543930053711%

ADMET: Metabolism

CYP1A2-inhibitor:	0.965
CYP1A2-substrate:	0.937
CYP2C19-inhibitor:	0.573
CYP2C19-substrate:	0.07
CYP2C9-inhibitor:	0.053
CYP2C9-substrate:	0.557
CYP2D6-inhibitor:	0.977
CYP2D6-substrate:	0.892
CYP3A4-inhibitor:	0.034
CYP3A4-substrate:	0.193

ADMET: Excretion

Clearance (CL):	2.833
Half-life (T1/2):	0.671

ADMET: Toxicity

hERG Blockers:	0.074
Human Hepatotoxicity (H-HT):	0.854
Drug-inuced Liver Injury (DILI):	0.038
AMES Toxicity:	0.308
Rat Oral Acute Toxicity:	0.869
Maximum Recommended Daily Dose:	0.891
Skin Sensitization:	0.601
Carcinogencity:	0.579
Eye Corrosion:	0.014
Eye Irritation:	0.666
Respiratory Toxicity:	0.983

Download Data

Data Type	Select
General Info & Identifiers & Properties
Structure MOL file
Source Organisms
Biological Activities
Similar NPs/Drugs

Natural Product: NPC479379

Natural Product ID:	NPC479379
*Common Name:**	YLJREFDVOIBQDA-UHFFFAOYSA-N
IUPAC Name:	n.a.
Synonyms:
Standard InCHIKey:	YLJREFDVOIBQDA-UHFFFAOYSA-N
Standard InCHI:	InChI=1S/C13H14N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1,3,5,7H,2,4,6,8H2,(H2,14,15)
SMILES:	c1ccc2c(c1)c(=N)c1CCCCc1[nH]2
Synthetic Gene Cluster:	n.a.
ChEMBL Identifier:	n.a.
PubChem CID:	1935
Chemical Classification:**	CHEMONTID:0000000 [Organic compounds] [CHEMONTID:0000002] Organoheterocyclic compounds [CHEMONTID:0001253] Quinolines and derivatives [CHEMONTID:0001908] Benzoquinolines [CHEMONTID:0000274] Acridines

*Note: the InCHIKey will be temporarily assigned as the "Common Name" if no IUPAC name or alternative short name is available.
**Note: the Chemical Classification was calculated by NPClassifier Version 1.5. Reference: PMID:34662515.

Species Source

Organism ID	Organism Name	Taxonomy Level	Family	SuperKingdom	Isolation Part	Collection Location	Collection Time	Reference
NPO4391	Hypericum perforatum	Species	Hypericaceae	Eukaryota	n.a.	n.a.	n.a.	DOI[10.1078/0176-1617-00195]
NPO4391	Hypericum perforatum	Species	Hypericaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[10757735]
NPO4391	Hypericum perforatum	Species	Hypericaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[14735439]
NPO4391	Hypericum perforatum	Species	Hypericaceae	Eukaryota	n.a.	callus	n.a.	PMID[15715262]
NPO686	Magnolia x soulangiana	Hybrid Species	Magnoliaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[16989531]
NPO4391	Hypericum perforatum	Species	Hypericaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[18220354]
NPO21757	Selaginella moellendorfii	Species	Selaginellaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[19422203]
NPO25456	Cortinarius infractus	Species	Cortinariaceae	Eukaryota	Toadstool	n.a.	n.a.	PMID[20176490]
NPO40192	Macaranga kurzii	Species	Euphorbiaceae	Eukaryota	Leaves	n.a.	n.a.	PMID[23134335]
NPO40864	Hypericum uralum	Species	Hypericaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[26583263]
NPO40864	Hypericum uralum	Species	Hypericaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[27148858]
NPO4391	Hypericum perforatum	Species	Hypericaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[28445039]
NPO40902	Palicourea sessilis	Species	Rubiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[29120642]
NPO21757	Selaginella moellendorfii	Species	Selaginellaceae	Eukaryota	Whole Plants	n.a.	n.a.	PMID[29412669]
NPO4391	Hypericum perforatum	Species	Hypericaceae	Eukaryota	Roots	n.a.	n.a.	PMID[30024167]
NPO40114	Elaeocarpus angustifolius	Species	Elaeocarpaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[31736307]
NPO40308	Psychotria nemorosa	Species	Rubiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[32150413]
NPO41015	Ballota hispanica	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[32818604]
NPO21757	Selaginella moellendorfii	Species	Selaginellaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[9134745]
NPO4391	Hypericum perforatum	Species	Hypericaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO21757	Selaginella moellendorfii	Species	Selaginellaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO4391	Hypericum perforatum	Species	Hypericaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO21757	Selaginella moellendorfii	Species	Selaginellaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO4391	Hypericum perforatum	Species	Hypericaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO4391	Hypericum perforatum	Species	Hypericaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO686	Magnolia x soulangiana	Hybrid Species	Magnoliaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO25456	Cortinarius infractus	Species	Cortinariaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO4391	Hypericum perforatum	Species	Hypericaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO21757	Selaginella moellendorfii	Species	Selaginellaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]

☑ Note for Reference:
In addition to directly collecting NP source organism data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated them from below databases:
☉ UNPD: Universal Natural Products Database [PMID: 23638153].
☉ StreptomeDB: a database of streptomycetes natural products [PMID: 33051671].
☉ TM-MC: a database of medicinal materials and chemical compounds in Northeast Asian traditional medicine [PMID: 26156871].
☉ TCM@Taiwan: a Traditional Chinese Medicine database [PMID: 21253603].
☉ TCMID: a Traditional Chinese Medicine database [PMID: 29106634].
☉ TCMSP: The traditional Chinese medicine systems pharmacology database and analysis platform [PMID: 24735618].
☉ HerDing: a herb recommendation system to treat diseases using genes and chemicals [PMID: 26980517].
☉ MetaboLights: a metabolomics database [PMID: 27010336].
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].

NP Quantity Composition/Concentration

Organism ID	NP ID	Organism Material Preparation	Organism Part	NP Quantity (Standard)	NP Quantity (Minimum)	NP Quantity (Maximum)	Quantity Unit	Reference

☑ Note for Reference:
In addition to directly collecting NP quantitative data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated NP quantitative records for specific NP domains (e.g., NPS from foods or herbs) from domain-specific databases. These databases include:
☉ DUKE: Dr. Duke's Phytochemical and Ethnobotanical Databases.
☉ PHENOL EXPLORER: is the first comprehensive database on polyphenol content in foods [PMID: 24103452], its homepage can be accessed at here.
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].

Biological Activity

Activity Type	# Activity
EC50	10
ED50	7
GI50	6
IC50	694
Kd	4
Ki	41
LD50	8
Others	482

Activity Type	# Activity
Cell Line	115
CELL-LINE	2
Individual Protein	790
NON-MOLECULAR	11
Organism	109
Others	205
Protein Complex	8
Protein Family	5
SELECTIVITY GROUP	2
SINGLE PROTEIN	3
Subcellular	1
Tissue	3

Target ID	Target Type	Target Name	Target Organism	Activity Type	Activity Relation	Value	Unit	Reference
NPT3902	Individual Protein	Acetylcholinesterase	Mus musculus	IC50	=	80.3	nM	PMID[7490731]
NPT2748	Individual Protein	Butyrylcholinesterase	Rattus norvegicus	IC50	=	73.0	nM	PMID[7490731]
NPT2749	Individual Protein	Acetylcholinesterase	Rattus norvegicus	IC50	=	319.0	nM	PMID[2754707]
NPT3986	Individual Protein	Norepinephrine transporter	Rattus norvegicus	IC50	=	11000.0	nM	PMID[2754707]
NPT1072	Individual Protein	Serotonin transporter	Rattus norvegicus	IC50	=	19000.0	nM	PMID[2754707]
NPT1073	Individual Protein	Dopamine transporter	Rattus norvegicus	IC50	=	22000.0	nM	PMID[2754707]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	16.0	nM	PMID[12824041]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	0.9	nM	PMID[12824041]
NPT2569	Individual Protein	Butyrylcholinesterase	Equus caballus	Ki	=	7.0	nM	PMID[12502352]
NPT2749	Individual Protein	Acetylcholinesterase	Rattus norvegicus	IC50	=	310.0	nM	PMID[3385720]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	4570881896148752.0	nM	PMID[9784091]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	2754228703338174.5	nM	PMID[9784091]
NPT1722	Individual Protein	Choline acetylase	Rattus norvegicus	Ki	=	0.151	nM	PMID[9784091]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	254.0	nM	DOI[10.1016/S0960-894X(97)10025-7]
NPT2748	Individual Protein	Butyrylcholinesterase	Rattus norvegicus	IC50	=	54.7	nM	DOI[10.1016/S0960-894X(97)10025-7]
NPT2749	Individual Protein	Acetylcholinesterase	Rattus norvegicus	IC50	=	200.0	nM	DOI[10.1016/S0960-894X(97)10025-7]
NPT2569	Individual Protein	Butyrylcholinesterase	Equus caballus	Ki	=	7.0	nM	PMID[11425559]
NPT3902	Individual Protein	Acetylcholinesterase	Mus musculus	Kd	=	18.0	nM	PMID[15214773]
NPT2749	Individual Protein	Acetylcholinesterase	Rattus norvegicus	IC50	=	590.0	nM	PMID[15214773]
NPT2749	Individual Protein	Acetylcholinesterase	Rattus norvegicus	IC50	=	63.0	nM	PMID[7636858]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	33.5	nM	DOI[10.1016/S0960-894X(00)80545-4]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	9.33	nM	DOI[10.1016/S0960-894X(00)80545-4]
NPT2569	Individual Protein	Butyrylcholinesterase	Equus caballus	IC50	=	5.17	nM	DOI[10.1016/S0960-894X(00)80545-4]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	143.0	nM	DOI[10.1016/S0960-894X(00)80267-X]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	39.0	nM	PMID[11495583]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	95.0	nM	PMID[11495583]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	21.0	nM	PMID[11495583]
NPT56	Individual Protein	Beta-lactamase AmpC	Escherichia coli K-12	Inhibition	<	5.0	%	PMID[14521410]
NPT1569	Individual Protein	Chymotrypsin C	Homo sapiens	Inhibition	<	5.0	%	PMID[14521410]
NPT2683	Individual Protein	Malate dehydrogenase cytoplasmic	Homo sapiens	Inhibition	=	83.0	%	PMID[14521410]
NPT2749	Individual Protein	Acetylcholinesterase	Rattus norvegicus	IC50	=	110.0	nM	PMID[8126709]
NPT2749	Individual Protein	Acetylcholinesterase	Rattus norvegicus	ID50	>	15.0	mg.kg-1	PMID[8126709]
NPT2749	Individual Protein	Acetylcholinesterase	Rattus norvegicus	ID50	=	20.0	mg.kg-1	PMID[8126709]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	180.0	nM	PMID[11689088]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	269.77	nM	PMID[8558505]
NPT2668	Individual Protein	Acetylcholinesterase	Torpedo californica	IC50	=	39.0	nM	PMID[10052979]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	95.0	nM	PMID[10052979]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	21.0	nM	PMID[10052979]
NPT3902	Individual Protein	Acetylcholinesterase	Mus musculus	IC50	=	81.0	nM	PMID[1469686]
NPT2748	Individual Protein	Butyrylcholinesterase	Rattus norvegicus	IC50	=	73.0	nM	PMID[1469686]
NPT2749	Individual Protein	Acetylcholinesterase	Rattus norvegicus	IC50	=	320.0	nM	PMID[8558529]
NPT228	Individual Protein	Norepinephrine transporter	Homo sapiens	IC50	=	11000.0	nM	PMID[8558529]
NPT2668	Individual Protein	Acetylcholinesterase	Torpedo californica	IC50	=	8.2	nM	PMID[11563919]
NPT2668	Individual Protein	Acetylcholinesterase	Torpedo californica	IC50	=	50.0	nM	PMID[12729674]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	50.0	nM	PMID[10762042]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	76.0	nM	PMID[8978837]
NPT2749	Individual Protein	Acetylcholinesterase	Rattus norvegicus	IC50	=	333.0	nM	PMID[12014965]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	89.0	nM	PMID[12014965]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	251.19	nM	PMID[12620072]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	53.7	nM	PMID[12620072]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	Ki	=	151.0	nM	PMID[12620072]
NPT2749	Individual Protein	Acetylcholinesterase	Rattus norvegicus	IC50	=	223.0	nM	PMID[10476864]
NPT2748	Individual Protein	Butyrylcholinesterase	Rattus norvegicus	IC50	=	92.0	nM	PMID[10476864]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	250.0	nM	PMID[10821713]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	Ki	=	10.0	nM	DOI[10.1016/0960-894X(95)00179-W]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	170.0	nM	PMID[7636841]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	6.0	nM	PMID[7636841]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	43.9	nM	PMID[10464010]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	190.0	nM	PMID[12166941]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	47.0	nM	PMID[12166941]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	270.0	nM	PMID[8064800]
NPT2569	Individual Protein	Butyrylcholinesterase	Equus caballus	IC50	=	6.0	nM	PMID[8064800]
NPT2749	Individual Protein	Acetylcholinesterase	Rattus norvegicus	IC50	=	160.0	nM	PMID[12646025]
NPT2748	Individual Protein	Butyrylcholinesterase	Rattus norvegicus	IC50	=	240.0	nM	PMID[12646025]
NPT2749	Individual Protein	Acetylcholinesterase	Rattus norvegicus	IC50	=	270.9	nM	PMID[8057278]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	78.0	nM	PMID[8709135]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	75.0	nM	PMID[8709135]
NPT2749	Individual Protein	Acetylcholinesterase	Rattus norvegicus	IC50	=	46.0	nM	PMID[8709135]
NPT3902	Individual Protein	Acetylcholinesterase	Mus musculus	IC50	=	143.0	nM	PMID[8709135]
NPT2749	Individual Protein	Acetylcholinesterase	Rattus norvegicus	IC50	=	78.0	nM	PMID[9357518]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	25.0	nM	PMID[9357518]
NPT1072	Individual Protein	Serotonin transporter	Rattus norvegicus	IC50	=	7600.0	nM	PMID[9357518]
NPT3986	Individual Protein	Norepinephrine transporter	Rattus norvegicus	IC50	=	7900.0	nM	PMID[9357518]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	76.03	nM	PMID[9435905]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	52.0	nM	PMID[1738151]
NPT2749	Individual Protein	Acetylcholinesterase	Rattus norvegicus	IC50	=	200.0	nM	DOI[10.1016/0960-894X(96)00102-3]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	30.0	nM	DOI[10.1016/0960-894X(96)00102-3]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	205.0	nM	PMID[11101357]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	43.9	nM	PMID[11101357]
NPT3902	Individual Protein	Acetylcholinesterase	Mus musculus	Inhibition	=	0.0	%	PMID[11101357]
NPT2749	Individual Protein	Acetylcholinesterase	Rattus norvegicus	IC50	=	80.6	nM	DOI[10.1016/S0960-894X(00)80547-8]
NPT2748	Individual Protein	Butyrylcholinesterase	Rattus norvegicus	IC50	=	73.0	nM	DOI[10.1016/S0960-894X(00)80547-8]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	180.0	nM	PMID[1507203]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	23.0	nM	PMID[1507203]
NPT1295	Individual Protein	Muscarinic acetylcholine receptor M1	Mus musculus	IC50	=	2000.0	nM	PMID[1507203]
NPT1301	Individual Protein	Muscarinic acetylcholine receptor M2	Rattus norvegicus	IC50	=	2100.0	nM	PMID[1507203]
NPT263	Individual Protein	Muscarinic acetylcholine receptor M2	Homo sapiens	Ki	=	5800.0	nM	PMID[1507203]
NPT1296	Individual Protein	Muscarinic acetylcholine receptor M2	Mus musculus	Ki	=	220.0	nM	PMID[1507203]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	267.0	nM	PMID[7707311]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	6.0	nM	PMID[7707311]
NPT2749	Individual Protein	Acetylcholinesterase	Rattus norvegicus	IC50	=	230.0	nM	DOI[10.1016/S0960-894X(00)80546-6]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	180.0	nM	PMID[1552502]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	23.0	nM	PMID[1552502]
NPT1295	Individual Protein	Muscarinic acetylcholine receptor M1	Mus musculus	IC50	=	2000.0	nM	PMID[1552502]
NPT1296	Individual Protein	Muscarinic acetylcholine receptor M2	Mus musculus	IC50	=	2100.0	nM	PMID[1552502]
NPT2569	Individual Protein	Butyrylcholinesterase	Equus caballus	Ki	=	7.0	nM	PMID[15771436]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	190.0	nM	PMID[15715468]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	47.0	nM	PMID[15715468]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	Ki	=	151.0	nM	PMID[15633997]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	424.0	nM	PMID[15633997]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	45.8	nM	PMID[15633997]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	90.0	nM	PMID[15603953]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	10.0	nM	PMID[15603953]
NPT2749	Individual Protein	Acetylcholinesterase	Rattus norvegicus	IC50	=	223.0	nM	PMID[15324879]
NPT2748	Individual Protein	Butyrylcholinesterase	Rattus norvegicus	IC50	=	92.0	nM	PMID[15324879]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	33.88	nM	PMID[15317459]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	251.19	nM	PMID[15317459]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	267.0	nM	PMID[15887964]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	27.0	nM	PMID[15887964]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	424.0	nM	PMID[15658850]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	45.8	nM	PMID[15658850]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	200.0	nM	PMID[15878275]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	0.04	ug.mL-1	PMID[15878275]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	Ki	=	25.0	nM	PMID[16366609]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	27.0	nM	PMID[16366609]
NPT2569	Individual Protein	Butyrylcholinesterase	Equus caballus	IC50	=	10.0	nM	PMID[16420031]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	350.0	nM	PMID[16420031]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	40.0	nM	PMID[16420031]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	190.0	nM	PMID[16570913]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	47.0	nM	PMID[16570913]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	Ki	=	137.0	nM	PMID[16722663]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	Ki	=	7.0	nM	PMID[16722663]
NPT2748	Individual Protein	Butyrylcholinesterase	Rattus norvegicus	IC50	=	92.0	nM	PMID[16942022]
NPT2749	Individual Protein	Acetylcholinesterase	Rattus norvegicus	IC50	=	223.0	nM	PMID[16942022]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	205.0	nM	PMID[17154513]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	43.9	nM	PMID[17154513]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	180.0	nM	PMID[17181144]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	147.0	nM	PMID[17181144]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	36.0	nM	PMID[17181144]
NPT519	Cell Line	SH-SY5Y	Homo sapiens	Activity	=	90.4	%	PMID[17181144]
NPT519	Cell Line	SH-SY5Y	Homo sapiens	Activity	=	13.4	%	PMID[17181144]
NPT519	Cell Line	SH-SY5Y	Homo sapiens	Activity	=	100.34	%	PMID[17181144]
NPT519	Cell Line	SH-SY5Y	Homo sapiens	Activity	=	0.0	%	PMID[17181144]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	426.58	nM	PMID[15588084]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	45.71	nM	PMID[15588084]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	24.0	nM	PMID[16279781]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	Inhibition	=	0.0	%	PMID[16279781]
NPT6226	Individual Protein	Acetylcholine receptor protein epsilon chain	Homo sapiens	IC50	=	44.0	nM	PMID[16279811]
NPT744	Cell Line	IMR-32	Homo sapiens	Activity	=	42.0	%	PMID[17681794]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	150.0	nM	PMID[17681794]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	30.0	nM	PMID[17681794]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	Inhibition	=	0.0	%	PMID[17681794]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	424.0	nM	PMID[17850125]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	45.8	nM	PMID[17850125]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	74.0	nM	PMID[17902635]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	58.0	nM	PMID[17902635]
NPT2668	Individual Protein	Acetylcholinesterase	Torpedo californica	IC50	=	157.0	nM	PMID[17902635]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	1030.0	nM	PMID[17902635]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	300.0	nM	PMID[17944454]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	926.0	nM	PMID[17944454]
NPT2843	Individual Protein	Muscarinic acetylcholine receptor M2	Sus scrofa	EC50	=	6300.0	nM	PMID[17944454]
NPT2843	Individual Protein	Muscarinic acetylcholine receptor M2	Sus scrofa	EC50	=	6309.57	nM	PMID[17944454]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	424.0	nM	PMID[18047264]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	45.8	nM	PMID[18047264]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	200.0	nM	PMID[17822295]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	420.0	nM	PMID[18181565]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	Activity	=	7.0	%	PMID[18181565]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	45.1	nM	PMID[18232655]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	5.1	nM	PMID[18232655]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	45.1	nM	PMID[18406135]
NPT2569	Individual Protein	Butyrylcholinesterase	Equus caballus	IC50	=	5.1	nM	PMID[18406135]
NPT2749	Individual Protein	Acetylcholinesterase	Rattus norvegicus	IC50	=	200.0	nM	PMID[17624631]
NPT2748	Individual Protein	Butyrylcholinesterase	Rattus norvegicus	IC50	=	9.0	nM	PMID[17624631]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	Ki	=	36.0	nM	PMID[18786825]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	Ki	=	7.0	nM	PMID[18786825]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	Ki	=	7.0	nM	PMID[18479118]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	Ki	=	36.0	nM	PMID[18479118]
NPT2668	Individual Protein	Acetylcholinesterase	Torpedo californica	Ki	=	40.0	nM	PMID[18479118]
NPT2749	Individual Protein	Acetylcholinesterase	Rattus norvegicus	IC50	=	223.0	nM	PMID[18517184]
NPT2748	Individual Protein	Butyrylcholinesterase	Rattus norvegicus	IC50	=	92.0	nM	PMID[18517184]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	24.0	nM	PMID[18517184]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	100.0	nM	PMID[18524585]
NPT5968	Individual Protein	Histamine N-methyltransferase	Homo sapiens	Activity	=	10.0	nM	PMID[18789706]
NPT519	Cell Line	SH-SY5Y	Homo sapiens	Activity	=	0.0	%	PMID[19374444]
NPT519	Cell Line	SH-SY5Y	Homo sapiens	Activity	=	13.4	%	PMID[19374444]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	147.0	nM	PMID[19374444]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	36.0	nM	PMID[19374444]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	180.0	nM	PMID[19374444]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	130.0	nM	PMID[19374444]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	220.0	nM	PMID[16989531]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	424.0	nM	PMID[18605718]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	45.8	nM	PMID[18605718]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	Inhibition	=	7.0	%	PMID[18605718]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	180.0	nM	PMID[18640842]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	150.0	nM	PMID[18640842]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	36.0	nM	PMID[18640842]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	Ki	=	20.2	nM	PMID[18640842]
NPT519	Cell Line	SH-SY5Y	Homo sapiens	Activity	=	90.4	%	PMID[18640842]
NPT519	Cell Line	SH-SY5Y	Homo sapiens	Activity	=	13.4	%	PMID[18640842]
NPT519	Cell Line	SH-SY5Y	Homo sapiens	Activity	=	100.34	%	PMID[18640842]
NPT519	Cell Line	SH-SY5Y	Homo sapiens	Activity	=	0.0	%	PMID[18640842]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	45.1	nM	PMID[19053746]
NPT2569	Individual Protein	Butyrylcholinesterase	Equus caballus	IC50	=	5.1	nM	PMID[19053746]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	Inhibition	=	7.0	%	PMID[19243862]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	200.0	nM	PMID[19422203]
NPT2749	Individual Protein	Acetylcholinesterase	Rattus norvegicus	IC50	=	88.0	nM	PMID[19954865]
NPT232	Individual Protein	Cannabinoid CB1 receptor	Homo sapiens	Ki	>	1000.0	nM	PMID[20047331]
NPT1287	Individual Protein	Cannabinoid CB2 receptor	Homo sapiens	Ki	>	1000.0	nM	PMID[20047331]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	251.19	nM	PMID[20047331]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	128.0	nM	PMID[19726199]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	42.95	nM	PMID[20061157]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	45.71	nM	PMID[20158205]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	350.0	nM	PMID[19856923]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	40.0	nM	PMID[19856923]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	222.7	nM	PMID[20079560]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	45.08	nM	PMID[20361801]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	45.0	nM	PMID[20361801]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	173.0	nM	PMID[20472431]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	100.0	nM	PMID[20575555]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	27.0	nM	PMID[20575555]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	223.0	nM	PMID[20053484]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	350.0	nM	PMID[20545360]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	40.0	nM	PMID[20545360]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	Inhibition	=	49.0	%	PMID[20812738]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	800.0	nM	PMID[20684567]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	23.0	nM	PMID[20817518]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	500.0	nM	PMID[20817518]
NPT2569	Individual Protein	Butyrylcholinesterase	Equus caballus	IC50	=	41.0	nM	PMID[20880702]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	311.0	nM	PMID[20880702]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	74.0	nM	PMID[20943395]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	17.38	nM	PMID[20926161]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	27.0	nM	PMID[21163662]
NPT2569	Individual Protein	Butyrylcholinesterase	Equus caballus	IC50	=	27.08	nM	PMID[21211982]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	192.6	nM	PMID[21211982]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	27.0	nM	PMID[21111515]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	46.5	nM	PMID[21232964]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	46.45	nM	PMID[21232964]
NPT208	Individual Protein	Cytochrome P450 1A2	Homo sapiens	Ki	=	1940.0	nM	PMID[16248836]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	27.0	nM	PMID[21411323]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	200.0	nM	PMID[21216144]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	12.0	nM	PMID[21216144]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	110.0	nM	PMID[21417225]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	23.0	nM	PMID[21417225]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	105.0	nM	PMID[21367493]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	190.0	nM	PMID[21459491]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	47.0	nM	PMID[21459491]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	136.0	nM	PMID[21435752]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	484.0	nM	PMID[21435752]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	73.0	nM	PMID[21435752]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	Inhibition	=	7.0	%	PMID[21435752]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	250.0	nM	PMID[21641207]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	3.16	nM	PMID[21570751]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	0.0267	nM	PMID[21570751]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	250.0	nM	PMID[21798635]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	50.0	nM	PMID[21798635]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	Inhibition	<	5.0	%	PMID[21798635]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	Inhibition	=	4.5	%	PMID[21871694]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	104.0	nM	PMID[21871694]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	77.0	nM	PMID[21873056]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	500.0	nM	PMID[21920739]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	23.0	nM	PMID[21920739]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	311.0	nM	PMID[22019228]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	27.0	nM	PMID[22000936]
NPT519	Cell Line	SH-SY5Y	Homo sapiens	Activity	=	50.0	%	PMID[22000936]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	Inhibition	=	7.0	%	PMID[22023459]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	36.0	nM	PMID[22023459]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	122.0	nM	PMID[22023459]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	130.0	nM	PMID[22341944]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	Inhibition	=	4.5	%	PMID[22341944]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	Inhibition	=	0.0	%	PMID[22341944]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	Inhibition	=	7.0	%	PMID[22341944]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	96.0	nM	PMID[22444876]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	317.0	nM	PMID[22185619]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	24.5	nM	PMID[22185619]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	Inhibition	=	5.2	%	PMID[22185619]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	40.0	nM	PMID[22243648]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	350.0	nM	PMID[22243648]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	311.0	nM	PMID[22472046]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	27.0	nM	PMID[22503231]
NPT2569	Individual Protein	Butyrylcholinesterase	Equus caballus	IC50	=	5.2	nM	PMID[22503231]
NPT1488	Individual Protein	Monoamine oxidase A	Rattus norvegicus	IC50	=	40.0	nM	PMID[22503231]
NPT1487	Individual Protein	Monoamine oxidase B	Rattus norvegicus	IC50	>	100.0	nM	PMID[22503231]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	420.0	nM	PMID[22503231]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	46.0	nM	PMID[22503231]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	Inhibition	<	10.0	%	PMID[22503231]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	64.57	nM	PMID[22420827]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	27.0	nM	PMID[21715067]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	85.8	nM	PMID[22633691]
NPT213	Individual Protein	Cytochrome P450 2C19	Homo sapiens	Ratio IC50	<	2.0	n.a.	PMID[22931300]
NPT212	Individual Protein	Cytochrome P450 2C9	Homo sapiens	Ratio IC50	=	2.0	n.a.	PMID[22931300]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	109.0	nM	PMID[22944335]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	900.0	nM	PMID[22981331]
NPT1540	Individual Protein	Solute carrier family 22 member 2	Homo sapiens	IC50	=	680.0	nM	PMID[21599003]
NPT613	Individual Protein	Solute carrier family 22 member 1	Homo sapiens	IC50	=	83000.0	nM	PMID[21599003]
NPT4037	Individual Protein	Multidrug and toxin extrusion protein 1	Homo sapiens	IC50	=	1100.0	nM	PMID[21599003]
NPT4036	Individual Protein	Multidrug and toxin extrusion protein 2	Homo sapiens	IC50	>	100000.0	nM	PMID[21599003]
NPT3902	Individual Protein	Acetylcholinesterase	Mus musculus	IC50	=	130.0	nM	PMID[23026084]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	64.57	nM	PMID[23000296]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	Ki	=	8.72	nM	PMID[23041347]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	Ki	=	32.12	nM	PMID[23041347]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	50.0	nM	PMID[23134335]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	15.6	nM	PMID[22624880]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	45.71	nM	PMID[22624880]
NPT65	Cell Line	HepG2	Homo sapiens	Activity	=	40.0	%	PMID[22795665]
NPT65	Cell Line	HepG2	Homo sapiens	Activity	=	64.3	%	PMID[22795665]
NPT65	Cell Line	HepG2	Homo sapiens	Activity	=	81.6	%	PMID[22795665]
NPT65	Cell Line	HepG2	Homo sapiens	Activity	=	88.7	%	PMID[22795665]
NPT65	Cell Line	HepG2	Homo sapiens	Activity	=	90.0	%	PMID[22795665]
NPT65	Cell Line	HepG2	Homo sapiens	Activity	=	93.4	%	PMID[22795665]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	40.0	nM	PMID[22795665]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	350.0	nM	PMID[22795665]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	140.0	nM	DOI[10.1007/s00044-011-9695-0]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	20.0	nM	PMID[23199476]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	100.0	nM	PMID[23199476]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	Ki	=	340.0	nM	PMID[23330848]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	386.0	nM	PMID[23330848]
NPT2749	Individual Protein	Acetylcholinesterase	Rattus norvegicus	IC50	=	249.0	nM	PMID[23273608]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	110.2	nM	PMID[23454517]
NPT2749	Individual Protein	Acetylcholinesterase	Rattus norvegicus	IC50	=	230.0	nM	PMID[23380475]
NPT857	Cell Line	LLC-PK1	Sus scrofa	Ratio	=	1.2	n.a.	PMID[24900570]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	108.0	nM	PMID[23501115]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	69.8	nM	PMID[23639542]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	269.0	nM	PMID[23511019]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	183.0	nM	PMID[23535563]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	52.4	nM	PMID[23535563]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	269.0	nM	PMID[23685572]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	19.0	nM	PMID[23719283]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	268.0	nM	PMID[23719283]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	40.0	nM	PMID[23791077]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	160.0	nM	PMID[23791077]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	190.0	nM	PMID[23768661]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	520.0	nM	PMID[23891231]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	75.0	nM	PMID[23891231]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	410.0	nM	PMID[23988412]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	260.0	nM	PMID[24095756]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	58.0	nM	PMID[24140444]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	383.0	nM	PMID[24140444]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	Inhibition	=	10.3	%	PMID[24160297]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	534.0	nM	PMID[24160297]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	113.0	nM	PMID[24160297]
NPT261	Individual Protein	Monoamine oxidase A	Homo sapiens	Inhibition	=	31.2	%	PMID[24128814]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	285.0	nM	PMID[24128814]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	111.0	nM	PMID[24128814]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	285.0	nM	PMID[24220172]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	109.0	nM	PMID[24220172]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	219.0	nM	PMID[24148835]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	534.0	nM	PMID[24461494]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	110.0	nM	PMID[24461494]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	46.0	nM	PMID[24389509]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	424.0	nM	PMID[24389509]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	40.0	nM	PMID[24502897]
NPT65	Cell Line	HepG2	Homo sapiens	Activity	=	68.3	IU/L	PMID[24502897]
NPT65	Cell Line	HepG2	Homo sapiens	Activity	=	42.7	IU/L	PMID[24502897]
NPT65	Cell Line	HepG2	Homo sapiens	Activity	=	12.7	IU/L	PMID[24502897]
NPT65	Cell Line	HepG2	Homo sapiens	Activity	=	118.7	IU/L	PMID[24502897]
NPT65	Cell Line	HepG2	Homo sapiens	Activity	=	83.3	IU/L	PMID[24502897]
NPT65	Cell Line	HepG2	Homo sapiens	Activity	=	60.3	IU/L	PMID[24502897]
NPT65	Cell Line	HepG2	Homo sapiens	Activity	=	40.0	%	PMID[24502897]
NPT65	Cell Line	HepG2	Homo sapiens	Activity	=	64.3	%	PMID[24502897]
NPT65	Cell Line	HepG2	Homo sapiens	Activity	=	81.6	%	PMID[24502897]
NPT65	Cell Line	HepG2	Homo sapiens	Activity	=	88.7	%	PMID[24502897]
NPT65	Cell Line	HepG2	Homo sapiens	Activity	=	90.0	%	PMID[24502897]
NPT65	Cell Line	HepG2	Homo sapiens	Activity	=	93.4	%	PMID[24502897]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	90.0	nM	PMID[24521095]
NPT76	Cell Line	C6	Rattus norvegicus	Activity	=	50.0	%	PMID[24508831]
NPT4715	Cell Line	NG108-15	Murinae	Activity	=	56.83	%	PMID[24508831]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	50.0	nM	PMID[24508831]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	205.0	nM	DOI[10.1039/C3MD00376K]
NPT2668	Individual Protein	Acetylcholinesterase	Torpedo californica	IC50	=	52.4	nM	DOI[10.1039/C0MD00256A]
NPT2668	Individual Protein	Acetylcholinesterase	Torpedo californica	IC50	=	183.0	nM	DOI[10.1039/C0MD00256A]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	150.0	nM	DOI[10.1039/C1MD00221J]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	250.0	nM	PMID[24681980]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	200.0	nM	PMID[24704618]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	65.0	nM	PMID[24657052]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	Inhibition	=	59.9	%	PMID[24597894]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	230.0	nM	PMID[24738476]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	215.0	nM	PMID[24794747]
NPT65	Cell Line	HepG2	Homo sapiens	IC50	=	98730.0	nM	PMID[24794747]
NPT2668	Individual Protein	Acetylcholinesterase	Torpedo californica	IC50	=	29.0	nM	PMID[24835788]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	280.0	nM	PMID[25462245]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	24.1	nM	PMID[25047936]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	71.61	nM	PMID[25047936]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	71.5	nM	PMID[25047936]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	24.04	nM	PMID[25047936]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	Ki	=	35.7	nM	PMID[25088549]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	Ki	=	8.7	nM	PMID[25088549]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	500.0	nM	PMID[25089370]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	23.0	nM	PMID[25089370]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	Ki	=	225.0	nM	PMID[25089370]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	Ki	=	101.0	nM	PMID[25089370]
NPT2668	Individual Protein	Acetylcholinesterase	Torpedo californica	IC50	=	29.0	nM	PMID[25017625]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	300.0	nM	PMID[24934993]
NPT65	Cell Line	HepG2	Homo sapiens	GI	=	83.42	%	PMID[25313319]
NPT65	Cell Line	HepG2	Homo sapiens	GI	=	86.91	%	PMID[25313319]
NPT71	Cell Line	HEK293	Homo sapiens	GI	=	72.35	%	PMID[25313319]
NPT71	Cell Line	HEK293	Homo sapiens	GI	=	82.95	%	PMID[25313319]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	109.0	nM	PMID[25282266]
NPT2569	Individual Protein	Butyrylcholinesterase	Equus caballus	IC50	=	15.2	nM	PMID[25282266]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	285.0	nM	PMID[25282266]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	260.0	nM	PMID[25282654]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	467.0	nM	PMID[25282654]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	12.0	nM	PMID[25226236]
NPT3902	Individual Protein	Acetylcholinesterase	Mus musculus	IC50	=	106.0	nM	PMID[25226236]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	190.0	nM	PMID[25226236]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	500.0	nM	PMID[25259726]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	23.0	nM	PMID[25259726]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	73.0	nM	PMID[25597004]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	484.0	nM	PMID[25597004]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	136.0	nM	PMID[25597004]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	100.0	nM	PMID[25597007]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	24.0	nM	PMID[25707322]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	131.0	nM	PMID[25707322]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	47410.0	nM	PMID[25868744]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	435.1	nM	PMID[25656088]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	112.1	nM	PMID[25656088]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	23.2	nM	PMID[25656088]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	97.3	nM	PMID[25812965]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	24.0	nM	PMID[25621991]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	131.0	nM	PMID[25621991]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	420.32	nM	PMID[25812965]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	25.33	nM	PMID[25812965]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	280.0	nM	PMID[25969170]
NPT627	Individual Protein	Cytochrome P450 2B6	Homo sapiens	Inhibition	<	10.0	%	PMID[21467212]
NPT628	Individual Protein	Cytochrome P450 2C8	Homo sapiens	Inhibition	<	10.0	%	PMID[21467212]
NPT212	Individual Protein	Cytochrome P450 2C9	Homo sapiens	Inhibition	<	10.0	%	PMID[21467212]
NPT213	Individual Protein	Cytochrome P450 2C19	Homo sapiens	Inhibition	<	10.0	%	PMID[21467212]
NPT110	Individual Protein	Cytochrome P450 2D6	Homo sapiens	Inhibition	=	24.0	%	PMID[21467212]
NPT109	Individual Protein	Cytochrome P450 3A4	Homo sapiens	Inhibition	<	10.0	%	PMID[21467212]
NPT208	Individual Protein	Cytochrome P450 1A2	Homo sapiens	Inhibition	=	28.0	%	PMID[21467212]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	12.0	nM	PMID[26116179]
NPT3902	Individual Protein	Acetylcholinesterase	Mus musculus	IC50	=	106.0	nM	PMID[26116179]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	300.0	nM	PMID[26003339]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	126.7	nM	PMID[26242241]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	501.0	nM	PMID[26242241]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	27.2	nM	PMID[26278660]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	50.0	nM	PMID[26212777]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	200.0	nM	PMID[26159481]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	320.0	nM	PMID[26503905]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	80.0	nM	PMID[26503905]
NPT65	Cell Line	HepG2	Homo sapiens	IC50	=	19370.0	nM	PMID[26503905]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	Inhibition	=	95.0	%	PMID[26510670]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	58.0	nM	PMID[26510670]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	372.0	nM	PMID[26588065]
NPT65	Cell Line	HepG2	Homo sapiens	Inhibition	=	5.78	%	PMID[26752094]
NPT65	Cell Line	HepG2	Homo sapiens	Inhibition	=	15.05	%	PMID[26752094]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	79.0	nM	PMID[26827140]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	34.0	nM	PMID[26827140]
NPT166	Individual Protein	Acyl coenzyme A:cholesterol acyltransferase	Homo sapiens	IC50	>	100000.0	nM	PMID[26827140]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	424.0	nM	PMID[26632651]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	45.8	nM	PMID[26632651]
NPT519	Cell Line	SH-SY5Y	Homo sapiens	Activity	=	33.8	%	PMID[26632651]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	330.0	nM	PMID[26583263]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	110.0	nM	PMID[26917219]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	190.0	nM	DOI[10.1039/C5MD00236B]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	40.0	nM	DOI[10.1039/C5MD00274E]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	160.0	nM	DOI[10.1039/C5MD00274E]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	2.0	nM	PMID[26869193]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	7.53	nM	PMID[27068142]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	Ki	=	7.64	nM	PMID[27068142]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	38.0	nM	PMID[27083471]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	73.36	nM	PMID[27061983]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	95.0	nM	PMID[27328658]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	190.0	nM	PMID[27128182]
NPT65	Cell Line	HepG2	Homo sapiens	EC50	=	179000.0	nM	PMID[27128182]
NPT519	Cell Line	SH-SY5Y	Homo sapiens	Activity	=	98.43	%	PMID[27128182]
NPT519	Cell Line	SH-SY5Y	Homo sapiens	Activity	=	86.04	%	PMID[27128182]
NPT519	Cell Line	SH-SY5Y	Homo sapiens	Activity	=	90.97	%	PMID[27128182]
NPT519	Cell Line	SH-SY5Y	Homo sapiens	Activity	=	81.39	%	PMID[27128182]
NPT519	Cell Line	SH-SY5Y	Homo sapiens	Activity	=	74.03	%	PMID[27128182]
NPT519	Cell Line	SH-SY5Y	Homo sapiens	Activity	=	37.62	%	PMID[27128182]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	230.0	nM	PMID[27460699]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	450.0	nM	PMID[27460699]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	30.0	nM	PMID[27460699]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	Inhibition	=	9.3	%	PMID[27227482]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	130.0	nM	PMID[27227482]
NPT2749	Individual Protein	Acetylcholinesterase	Rattus norvegicus	IC50	=	114.32	nM	PMID[27392529]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	22.73	nM	PMID[27392529]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	192.6	nM	PMID[27343850]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	61.0	nM	PMID[27376495]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	218.0	nM	PMID[27484514]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	459.0	nM	PMID[27484514]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	41.0	nM	PMID[27484514]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	12.0	nM	PMID[27484515]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	221.0	nM	PMID[27484515]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	23.0	nM	PMID[27908752]
NPT3902	Individual Protein	Acetylcholinesterase	Mus musculus	IC50	=	115.0	nM	PMID[27908752]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	24.0	nM	PMID[27560283]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	131.0	nM	PMID[27560283]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	Inhibition	=	99.16	%	PMID[27783974]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	Inhibition	=	98.9	%	PMID[27783974]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	Inhibition	=	95.95	%	PMID[27783974]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	Inhibition	=	75.05	%	PMID[27783974]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	Inhibition	=	36.64	%	PMID[27783974]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	Inhibition	=	20.4	%	PMID[27783974]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	Inhibition	=	17.05	%	PMID[27783974]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	371.5	nM	PMID[27783974]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	23.0	nM	PMID[27721153]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	130.0	nM	PMID[27918993]
NPT611	Cell Line	Hepatocyte	Homo sapiens	Activity	=	70.0	%	PMID[27918993]
NPT611	Cell Line	Hepatocyte	Homo sapiens	Activity	=	75.0	%	PMID[27918993]
NPT611	Cell Line	Hepatocyte	Homo sapiens	Activity	=	81.0	%	PMID[27918993]
NPT611	Cell Line	Hepatocyte	Homo sapiens	Activity	=	83.0	%	PMID[27918993]
NPT611	Cell Line	Hepatocyte	Homo sapiens	Activity	=	86.0	%	PMID[27918993]
NPT611	Cell Line	Hepatocyte	Homo sapiens	Activity	=	94.0	%	PMID[27918993]
NPT65	Cell Line	HepG2	Homo sapiens	Activity	=	13.7	%	PMID[27918993]
NPT65	Cell Line	HepG2	Homo sapiens	Activity	=	49.3	%	PMID[27918993]
NPT65	Cell Line	HepG2	Homo sapiens	Activity	=	110.5	%	PMID[27918993]
NPT65	Cell Line	HepG2	Homo sapiens	Activity	=	106.4	%	PMID[27918993]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	30.0	nM	PMID[27918993]
NPT65	Cell Line	HepG2	Homo sapiens	Activity	=	20.0	%	PMID[28064079]
NPT65	Cell Line	HepG2	Homo sapiens	Activity	=	50.0	%	PMID[28064079]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	356.0	nM	PMID[28189905]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	14.0	nM	PMID[28189905]
NPT65	Cell Line	HepG2	Homo sapiens	IC50	=	17.9	ug.mL-1	PMID[28189905]
NPT613	Individual Protein	Solute carrier family 22 member 1	Homo sapiens	IC50	=	21720.0	nM	PMID[28230985]
NPT613	Individual Protein	Solute carrier family 22 member 1	Homo sapiens	Ratio	=	1.26	n.a.	PMID[28230985]
NPT208	Individual Protein	Cytochrome P450 1A2	Homo sapiens	IC50	=	1500.0	nM	PMID[28400237]
NPT109	Individual Protein	Cytochrome P450 3A4	Homo sapiens	Inhibition	=	55.0	%	PMID[28400237]
NPT208	Individual Protein	Cytochrome P450 1A2	Homo sapiens	Inhibition	=	14.0	%	PMID[28400237]
NPT208	Individual Protein	Cytochrome P450 1A2	Homo sapiens	Inhibition	=	75.0	%	PMID[28400237]
NPT208	Individual Protein	Cytochrome P450 1A2	Homo sapiens	Inhibition	=	45.0	%	PMID[28400237]
NPT109	Individual Protein	Cytochrome P450 3A4	Homo sapiens	IC50	=	96900.0	nM	PMID[28400237]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	109.0	nM	PMID[28454848]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	9.1	nM	PMID[29400965]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	18.5	nM	PMID[29400965]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	10.0	nM	PMID[29400965]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	19.95	nM	PMID[29400965]
NPT612	Individual Protein	Canalicular multispecific organic anion transporter 1	Homo sapiens	IC50	>	133000.0	nM	PMID[23956101]
NPT1249	Individual Protein	Canalicular multispecific organic anion transporter 2	Homo sapiens	IC50	>	133000.0	nM	PMID[23956101]
NPT1028	Individual Protein	Multidrug resistance-associated protein 4	Homo sapiens	IC50	=	23700.0	nM	PMID[23956101]
NPT2668	Individual Protein	Acetylcholinesterase	Torpedo californica	IC50	=	100.0	nM	PMID[28302511]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	102.0	nM	PMID[27744252]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	48.0	nM	PMID[27863370]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	600.0	nM	PMID[28986116]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	300.0	nM	PMID[28242549]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	Inhibition	>	50.0	%	PMID[28242549]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	20.0	nM	PMID[28242549]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	Inhibition	>	50.0	%	PMID[28242549]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	Inhibition	=	9.1	%	PMID[28242549]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	600.0	nM	PMID[28578994]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	270.0	nM	PMID[28445039]
NPT2749	Individual Protein	Acetylcholinesterase	Rattus norvegicus	IC50	=	130.0	nM	PMID[29729987]
NPT2748	Individual Protein	Butyrylcholinesterase	Rattus norvegicus	IC50	=	80.0	nM	PMID[29729987]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	86.0	nM	PMID[30017112]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	110.0	nM	PMID[28841514]
NPT519	Cell Line	SH-SY5Y	Homo sapiens	Activity	=	38.0	%	PMID[28863358]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	230.0	nM	PMID[28863358]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	40.0	nM	PMID[28863358]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	424.0	nM	PMID[29031067]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	46.0	nM	PMID[29031067]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	Inhibition	=	57.8	%	PMID[29120642]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	226.0	nM	PMID[28478343]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	143.5	nM	PMID[29268129]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	Inhibition	=	37.15	%	PMID[29268129]
NPT65	Cell Line	HepG2	Homo sapiens	Inhibition	=	5.78	%	PMID[29268129]
NPT65	Cell Line	HepG2	Homo sapiens	Inhibition	=	11.95	%	PMID[29268129]
NPT65	Cell Line	HepG2	Homo sapiens	Inhibition	=	33.09	%	PMID[29268129]
NPT681	Cell Line	PC-12	Rattus norvegicus	Inhibition	<	5.0	%	PMID[29268129]
NPT681	Cell Line	PC-12	Rattus norvegicus	Inhibition	=	5.74	%	PMID[29268129]
NPT681	Cell Line	PC-12	Rattus norvegicus	Inhibition	=	14.66	%	PMID[29268129]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	89.91	nM	PMID[29353726]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	430.0	nM	PMID[29407958]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	21.0	nM	PMID[29407958]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	Inhibition	=	7.2	%	PMID[29857276]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	374.0	nM	PMID[29958119]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	44.2	nM	PMID[29958119]
NPT65	Cell Line	HepG2	Homo sapiens	Activity	=	66.3	%	PMID[29958119]
NPT65	Cell Line	HepG2	Homo sapiens	Activity	=	91.1	%	PMID[29958119]
NPT65	Cell Line	HepG2	Homo sapiens	Activity	=	90.0	%	PMID[29958119]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	Ki	=	27.0	nM	PMID[28728108]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	Ki	=	22.9	nM	PMID[28728108]
NPT81	Cell Line	A549	Homo sapiens	GI50	>	100000.0	nM	PMID[28728108]
NPT1723	Cell Line	HBL-100	Homo sapiens	GI50	=	50000.0	nM	PMID[28728108]
NPT165	Cell Line	HeLa	Homo sapiens	GI50	=	51000.0	nM	PMID[28728108]
NPT1577	Cell Line	SW1573	Homo sapiens	GI50	=	50000.0	nM	PMID[28728108]
NPT396	Cell Line	T47D	Homo sapiens	GI50	=	46000.0	nM	PMID[28728108]
NPT1183	Cell Line	WiDr	Homo sapiens	GI50	=	34000.0	nM	PMID[28728108]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	365.0	nM	PMID[28803044]
NPT65	Cell Line	HepG2	Homo sapiens	Activity	=	73.3	%	PMID[28803044]
NPT65	Cell Line	HepG2	Homo sapiens	Activity	=	77.3	%	PMID[28803044]
NPT65	Cell Line	HepG2	Homo sapiens	Activity	=	90.3	%	PMID[28803044]
NPT65	Cell Line	HepG2	Homo sapiens	Activity	=	94.2	%	PMID[28803044]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	Inhibition	=	7.0	%	PMID[28803044]
NPT65	Cell Line	HepG2	Homo sapiens	Activity	=	66.4	%	PMID[28803044]
NPT65	Cell Line	HepG2	Homo sapiens	Activity	=	58.3	%	PMID[28803044]
NPT65	Cell Line	HepG2	Homo sapiens	Activity	=	43.2	%	PMID[28803044]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	Inhibition	=	30.98	%	PMID[28810188]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	94.69	nM	PMID[28810188]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	76.5	nM	PMID[28923380]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	10.8	nM	PMID[28923380]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	70.7	nM	PMID[29466774]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	116.8	nM	PMID[29466774]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	34.4	nM	PMID[29466774]
NPT65	Cell Line	HepG2	Homo sapiens	Activity	=	92.5	%	PMID[29466774]
NPT65	Cell Line	HepG2	Homo sapiens	Activity	=	90.9	%	PMID[29466774]
NPT65	Cell Line	HepG2	Homo sapiens	Activity	=	89.8	%	PMID[29466774]
NPT65	Cell Line	HepG2	Homo sapiens	Activity	=	77.6	%	PMID[29466774]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	350000.0	nM	PMID[29466775]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	88.1	nM	PMID[29533874]
NPT262	Individual Protein	Muscarinic acetylcholine receptor M1	Homo sapiens	IC50	=	13000.0	nM	PMID[29533874]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	320.0	nM	PMID[29533874]
NPT65	Cell Line	HepG2	Homo sapiens	IC50	=	168470.0	nM	PMID[29533874]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	Kd	=	16.0	nM	PMID[29873484]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	600.0	nM	PMID[30104121]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	Inhibition	=	7.2	%	PMID[30190181]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	40.0	nM	PMID[29541355]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	230.0	nM	PMID[29541355]
NPT519	Cell Line	SH-SY5Y	Homo sapiens	IC50	=	120000.0	nM	PMID[29541355]
NPT65	Cell Line	HepG2	Homo sapiens	IC50	=	111000.0	nM	PMID[30108847]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	25.12	nM	PMID[30108847]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	40.0	nM	PMID[30108842]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	350.0	nM	PMID[30108842]
NPT65	Cell Line	HepG2	Homo sapiens	Activity	=	40.0	%	PMID[30108842]
NPT65	Cell Line	HepG2	Homo sapiens	Activity	=	64.3	%	PMID[30108842]
NPT65	Cell Line	HepG2	Homo sapiens	Activity	=	88.7	%	PMID[30108842]
NPT65	Cell Line	HepG2	Homo sapiens	Activity	=	93.4	%	PMID[30108842]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	316.0	nM	PMID[30108908]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	Inhibition	=	86.22	%	PMID[30108908]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	40.0	nM	PMID[30245401]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	230.0	nM	PMID[30245401]
NPT3902	Individual Protein	Acetylcholinesterase	Mus musculus	IC50	=	34.3	nM	PMID[30340901]
NPT5337	Individual Protein	Butyrylcholinesterase	Mus musculus	IC50	=	62.5	nM	PMID[30340901]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	23.2	nM	PMID[30031971]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	114.8	nM	PMID[30031971]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	300.0	nM	PMID[30579802]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	223.0	nM	PMID[30771604]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	412.0	nM	PMID[30771604]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	40.0	nM	PMID[30771604]
NPT65	Cell Line	HepG2	Homo sapiens	IC50	=	98000.0	nM	PMID[30771604]
NPT65	Cell Line	HepG2	Homo sapiens	EC100	=	0.97	uM	PMID[30771604]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	400.0	nM	PMID[30771601]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	20.0	nM	PMID[30771601]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	30.0	nM	PMID[30744931]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	95.0	nM	PMID[30744931]
NPT2749	Individual Protein	Acetylcholinesterase	Rattus norvegicus	IC50	=	590.0	nM	PMID[30744931]
NPT2748	Individual Protein	Butyrylcholinesterase	Rattus norvegicus	IC50	=	44.0	nM	PMID[30744931]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	69.8	nM	PMID[30744931]
NPT2749	Individual Protein	Acetylcholinesterase	Rattus norvegicus	IC50	=	131.0	nM	PMID[30744931]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	500.0	nM	PMID[30744931]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	280.0	nM	PMID[31136894]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	52.4	nM	PMID[32206241]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	425.6	nM	PMID[31401008]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	12.59	nM	PMID[31609608]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	12.59	nM	PMID[31609608]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	158.49	nM	PMID[31609608]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	158.49	nM	PMID[31609608]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	Inhibition	=	5.0	%	PMID[31609608]
NPT1287	Individual Protein	Cannabinoid CB2 receptor	Homo sapiens	Inhibition	=	29.0	%	PMID[31609608]
NPT232	Individual Protein	Cannabinoid CB1 receptor	Homo sapiens	Inhibition	=	24.0	%	PMID[31609608]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	Ki	=	23.0	nM	PMID[31376562]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	412.0	nM	PMID[31376562]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	44.2	nM	PMID[31376562]
NPT6226	Individual Protein	Acetylcholine receptor protein epsilon chain	Homo sapiens	Inhibition	=	92.8	%	PMID[31352246]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	350.0	nM	PMID[31352246]
NPT6226	Individual Protein	Acetylcholine receptor protein epsilon chain	Homo sapiens	Ki	=	152.28	nM	PMID[31352246]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	230.0	nM	PMID[30568755]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	930.0	nM	PMID[31191867]
NPT3902	Individual Protein	Acetylcholinesterase	Mus musculus	IC50	=	30.0	nM	PMID[32904099]
NPT5337	Individual Protein	Butyrylcholinesterase	Mus musculus	IC50	=	60.0	nM	PMID[32904099]
NPT189	Cell Line	Vero	Chlorocebus aethiops	IC50	=	168900.0	nM	PMID[32904099]
NPT65	Cell Line	HepG2	Homo sapiens	IC50	=	114900.0	nM	PMID[32904099]
NPT76	Cell Line	C6	Rattus norvegicus	IC50	=	450700.0	nM	PMID[32904099]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	31.8	nM	PMID[31669851]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	131.0	nM	PMID[31669851]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	23.0	nM	PMID[31812794]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	110.0	nM	PMID[31281020]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	33.5	nM	PMID[30798053]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	424.0	nM	PMID[30798053]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	320.0	nM	PMID[30851693]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	80.0	nM	PMID[30851693]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	Inhibition	=	8.1	%	PMID[30851693]
NPT913	Cell Line	CHO-K1	Cricetulus griseus	IC50	=	248000.0	nM	PMID[30851693]
NPT65	Cell Line	HepG2	Homo sapiens	IC50	=	190000.0	nM	PMID[30851693]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	55.0	nM	PMID[31479975]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	66.0	nM	PMID[31708262]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	79.0	nM	PMID[31708262]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	70.0	nM	PMID[31736307]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	230.0	nM	PMID[30686752]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	24.0	nM	PMID[27445168]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	107.0	nM	PMID[27405689]
NPT5539	Individual Protein	Fatty acid-binding protein, liver	Homo sapiens	Kd	=	900000.0	nM	PMID[27500412]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	50.0	nM	PMID[27253679]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	Inhibition	=	10.63	%	PMID[27253679]
NPT519	Cell Line	SH-SY5Y	Homo sapiens	Activity	=	89.4	%	PMID[27253679]
NPT519	Cell Line	SH-SY5Y	Homo sapiens	Activity	=	90.0	%	PMID[27253679]
NPT519	Cell Line	SH-SY5Y	Homo sapiens	Activity	=	44.7	%	PMID[27253679]
NPT519	Cell Line	SH-SY5Y	Homo sapiens	Activity	=	57.9	%	PMID[27253679]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	207.0	nM	PMID[31901382]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	70.0	nM	PMID[32150413]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	140.0	nM	PMID[30739821]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	36.0	nM	PMID[30739821]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	51.3	nM	PMID[31864798]
NPT2668	Individual Protein	Acetylcholinesterase	Torpedo californica	IC50	=	190.0	nM	PMID[31864798]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	140.0	nM	PMID[32165042]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	44.0	nM	PMID[32165042]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	100.0	nM	PMID[32165042]
NPT2749	Individual Protein	Acetylcholinesterase	Rattus norvegicus	IC50	=	600.0	nM	PMID[32539387]
NPT519	Cell Line	SH-SY5Y	Homo sapiens	Activity	=	29.5	%	PMID[32738978]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	480.0	nM	PMID[33120080]
NPT2748	Individual Protein	Butyrylcholinesterase	Rattus norvegicus	IC50	=	74.0	nM	PMID[33120080]
NPT2749	Individual Protein	Acetylcholinesterase	Rattus norvegicus	IC50	=	93.0	nM	PMID[33120080]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	44.3	nM	PMID[27736061]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	420.0	nM	PMID[27736061]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	25.0	nM	PMID[27736061]
NPT65	Cell Line	HepG2	Homo sapiens	Activity	=	64.3	%	PMID[27736061]
NPT65	Cell Line	HepG2	Homo sapiens	Activity	=	40.0	%	PMID[27736061]
NPT65	Cell Line	HepG2	Homo sapiens	Activity	=	34.4	%	PMID[27736061]
NPT591	Individual Protein	Glycogen synthase kinase-3 beta	Homo sapiens	IC50	>	1000.0	nM	PMID[33340937]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	190.0	nM	PMID[33340937]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	50.0	nM	PMID[33340937]
NPT2749	Individual Protein	Acetylcholinesterase	Rattus norvegicus	IC50	=	170.0	nM	PMID[32818604]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	45.0	nM	PMID[33039562]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	223.0	nM	PMID[33039562]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	84.0	nM	PMID[33039562]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	72.38	nM	PMID[33137375]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	131.0	nM	PMID[32882609]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	34.0	nM	PMID[32882609]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	39.6	nM	PMID[32950908]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	171.9	nM	PMID[32950908]
NPT591	Individual Protein	Glycogen synthase kinase-3 beta	Homo sapiens	IC50	>	1000.0	nM	PMID[32950908]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	130.0	nM	PMID[27157006]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	142.0	nM	PMID[27720328]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	320.0	nM	PMID[32706255]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	35.2	nM	PMID[32706255]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	Ratio IC50	=	3.0	n.a.	PMID[32706255]
NPT51	Individual Protein	Microtubule-associated protein tau	Homo sapiens	Inhibition	<	10.0	%	PMID[32706255]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	IC50	=	21.63	nM	PMID[33189440]
NPT519	Cell Line	SH-SY5Y	Homo sapiens	Activity	=	90.6	%	PMID[33189440]
NPT519	Cell Line	SH-SY5Y	Homo sapiens	Activity	=	1.2	%	PMID[33189440]
NPT519	Cell Line	SH-SY5Y	Homo sapiens	Activity	=	3.6	%	PMID[33189440]
NPT519	Cell Line	SH-SY5Y	Homo sapiens	Activity	=	4.6	%	PMID[33189440]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	85.0	nM	PMID[33310288]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	Inhibition	=	100.0	%	PMID[32380385]
NPT66	Individual Protein	Acetylcholinesterase	Electrophorus electricus	Inhibition	=	97.6	%	PMID[32380385]
NPT204	Individual Protein	Acetylcholinesterase	Homo sapiens	IC50	=	250.0	nM	PMID[32454229]
NPT439	Individual Protein	Butyrylcholinesterase	Homo sapiens	IC50	=	50.0	nM	PMID[32454229]
NPT3768	Others	Cholinesterases; ACHE & BCHE	Homo sapiens	Ratio	=	0.9	n.a.	PMID[7490731]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LD50	<	20.0	mg.kg-1	PMID[2754707]
NPT32	Organism	Mus musculus	Mus musculus	LD50	=	29.1	mg.kg-1	PMID[2754707]
NPT914	Individual Protein	Acetylcholinesterase	Bos taurus	Ki	=	40.0	nM	PMID[12502352]
NPT32	Organism	Mus musculus	Mus musculus	LD50	=	39.8	mg.kg-1	PMID[3385720]
NPT914	Individual Protein	Acetylcholinesterase	Bos taurus	Ki	=	40.0	nM	PMID[11425559]
NPT914	Individual Protein	Acetylcholinesterase	Bos taurus	IC50	=	550.0	nM	DOI[10.1016/0960-894X(95)00562-8]
NPT3061	Organism	Diabrotica undecimpunctata	Diabrotica undecimpunctata	LD50	>	1000.0	p.p.m.	DOI[10.1016/0960-894X(95)00562-8]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	IC50	=	30000.0	nM	PMID[7861407]
NPT991	Individual Protein	Trypanothione reductase	Trypanosoma cruzi	Ki	=	140000.0	nM	PMID[10639286]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	10.0	mg.kg-1	PMID[8126709]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	5.0	mg.kg-1	PMID[8126709]
NPT32	Organism	Mus musculus	Mus musculus	LD50	=	23.0	mg.kg-1	PMID[8126709]
NPT2	Others	Unspecified		Ratio	=	0.22	n.a.	PMID[10052979]
NPT2	Others	Unspecified		Ratio	=	0.9	n.a.	PMID[1469686]
NPT422	Protein Family	Muscarinic acetylcholine receptor	Rattus norvegicus	IC50	=	7300.0	nM	PMID[8558529]
NPT422	Protein Family	Muscarinic acetylcholine receptor	Rattus norvegicus	IC50	=	5900.0	nM	PMID[8558529]
NPT32	Organism	Mus musculus	Mus musculus	ED50	>	10.0	mg.kg-1	PMID[8558529]
NPT422	Protein Family	Muscarinic acetylcholine receptor	Rattus norvegicus	Ratio	=	1.2	n.a.	PMID[8558529]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	9.0	mg.kg-1	PMID[7636841]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	20.0	mg.kg-1	PMID[7636841]
NPT27	Others	Unspecified		LD50	=	70.0	mg.kg-1	PMID[7636841]
NPT2	Others	Unspecified		Ratio	=	0.04	n.a.	PMID[7636841]
NPT914	Individual Protein	Acetylcholinesterase	Bos taurus	IC50	=	130.0	nM	PMID[10464010]
NPT2	Others	Unspecified		Ratio	=	0.34	n.a.	PMID[10464010]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	14.0	mg.kg-1	PMID[8064800]
NPT3768	Others	Cholinesterases; ACHE & BCHE	Homo sapiens	Ratio	=	0.022	n.a.	PMID[8064800]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	14.9	mg.kg-1	PMID[8057278]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LD50	=	102.2	mg.kg-1	PMID[8057278]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Therapeutic index	=	10.2	n.a.	PMID[8057278]
NPT19082	SINGLE PROTEIN	Histamine N-methyltransferase	Rattus norvegicus	IC50	=	110.0	nM	PMID[11855993]
NPT914	Individual Protein	Acetylcholinesterase	Bos taurus	IC50	=	130.0	nM	PMID[11101357]
NPT2	Others	Unspecified		Ratio	=	0.63	n.a.	PMID[11101357]
NPT2	Others	Unspecified		Ratio	=	0.21	n.a.	PMID[11101357]
NPT3768	Others	Cholinesterases; ACHE & BCHE	Homo sapiens	Ratio	=	0.9	n.a.	DOI[10.1016/S0960-894X(00)80547-8]
NPT3768	Others	Cholinesterases; ACHE & BCHE	Homo sapiens	Ratio	=	0.1	n.a.	PMID[1507203]
NPT1300	Others	Muscarinic acetylcholine receptors; M1 & M2	Homo sapiens	Ratio	=	1.1	n.a.	PMID[1507203]
NPT2	Others	Unspecified		Ratio	=	26.0	n.a.	PMID[1507203]
NPT27	Others	Unspecified		LD50	>	20.0	mg.kg-1	DOI[10.1016/S0960-894X(00)80546-6]
NPT32	Organism	Mus musculus	Mus musculus	Ki	=	5800.0	nM	PMID[1552502]
NPT32	Organism	Mus musculus	Mus musculus	Ki	=	220.0	nM	PMID[1552502]
NPT2	Others	Unspecified		Ratio	=	26.0	n.a.	PMID[1552502]
NPT3768	Others	Cholinesterases; ACHE & BCHE	Homo sapiens	Ratio	=	0.13	n.a.	PMID[1552502]
NPT1300	Others	Muscarinic acetylcholine receptors; M1 & M2	Homo sapiens	Ratio	=	1.0	n.a.	PMID[1552502]
NPT914	Individual Protein	Acetylcholinesterase	Bos taurus	Ki	=	40.0	nM	PMID[15771436]
NPT914	Individual Protein	Acetylcholinesterase	Bos taurus	IC50	=	40.0	nM	PMID[16420031]
NPT3768	Others	Cholinesterases; ACHE & BCHE	Homo sapiens	Ratio IC50	=	0.1	n.a.	PMID[16420031]
NPT3768	Others	Cholinesterases; ACHE & BCHE	Homo sapiens	Ratio IC50	=	4.0	n.a.	PMID[16570913]
NPT26049	SELECTIVITY GROUP	Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)	Rattus norvegicus	Ratio IC50	=	0.4	n.a.	PMID[16942022]
NPT914	Individual Protein	Acetylcholinesterase	Bos taurus	IC50	=	130.0	nM	PMID[17154513]
NPT2	Others	Unspecified		Ratio IC50	=	0.24	n.a.	PMID[17181144]
NPT914	Individual Protein	Acetylcholinesterase	Bos taurus	IC50	=	167.0	nM	PMID[16279781]
NPT2	Others	Unspecified		Ratio IC50	=	6.9	n.a.	PMID[16279781]
NPT2	Others	Unspecified		Ratio IC50	=	5.0	n.a.	PMID[17681794]
NPT2	Others	Unspecified		IC50	>	150000.0	nM	PMID[17681794]
NPT78	Individual Protein	Beta amyloid A4 protein	Homo sapiens	Inhibition	<	5.0	%	PMID[17850125]
NPT914	Individual Protein	Acetylcholinesterase	Bos taurus	IC50	=	446.0	nM	PMID[17902635]
NPT2	Others	Unspecified		IC50	=	10.2	nM	PMID[17944454]
NPT2	Others	Unspecified		Ratio IC50	=	91.0	n.a.	PMID[17944454]
NPT2	Others	Unspecified		Inhibition	<	7.0	%	PMID[18047264]
NPT2	Others	Unspecified		Ratio IC50	=	8.8	n.a.	PMID[18232655]
NPT3912	Tissue	Artery	Sus scrofa	EC50	=	97300.0	nM	PMID[18232655]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	4.5	micromol/s	PMID[18232655]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	3.4	micromol/s	PMID[18232655]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	3.1	micromol/s	PMID[18232655]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	16.0	g/L	PMID[18232655]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	15.0	g/L	PMID[18232655]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	13.1	g/L	PMID[18232655]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	5.5	micromol/s	PMID[18232655]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	10.0	micromol/s	PMID[18232655]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	6.5	micromol/s	PMID[18232655]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	118.0	mg/g	PMID[18232655]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	92.0	mg/g	PMID[18232655]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	Activity	=	0.2	n.a.	PMID[18406135]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	4.0	nM	PMID[17624631]
NPT2	Others	Unspecified		Ratio Ki	=	5.14	n.a.	PMID[18479118]
NPT914	Individual Protein	Acetylcholinesterase	Bos taurus	IC50	=	445.0	nM	PMID[18479118]
NPT914	Individual Protein	Acetylcholinesterase	Bos taurus	IC50	=	167.0	nM	PMID[18517184]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	10.0	nM	PMID[18524585]
NPT2	Others	Unspecified		Ratio IC50	=	0.1	n.a.	PMID[18524585]
NPT3768	Others	Cholinesterases; ACHE & BCHE	Homo sapiens	Ratio IC50	=	0.24	n.a.	PMID[19374444]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	40.0	nM	PMID[16989531]
NPT2	Others	Unspecified		Inhibition	<	5.0	%	PMID[18605718]
NPT2	Others	Unspecified		Ratio IC50	=	0.24	n.a.	PMID[18640842]
NPT914	Individual Protein	Acetylcholinesterase	Bos taurus	IC50	=	134.0	nM	PMID[18585045]
NPT2	Others	Unspecified		Ratio IC50	=	8.8	n.a.	PMID[19053746]
NPT2	Others	Unspecified		Ratio Ki	>	20.0	n.a.	PMID[20047331]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	6.95	nM	PMID[20061157]
NPT2	Others	Unspecified		Ratio IC50	=	8.8	n.a.	PMID[20158205]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	5.129	nM	PMID[20158205]
NPT914	Individual Protein	Acetylcholinesterase	Bos taurus	IC50	=	710.0	nM	PMID[20176490]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	10.0	nM	PMID[20176490]
NPT2	Others	Unspecified		Ratio IC50	=	0.01	n.a.	PMID[20176490]
NPT914	Individual Protein	Acetylcholinesterase	Bos taurus	IC50	=	40.0	nM	PMID[19856923]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	10.0	nM	PMID[19856923]
NPT2	Others	Unspecified		IC50	=	100.0	nM	PMID[19856923]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	29.98	nM	PMID[20079560]
NPT2	Others	Unspecified		Ratio IC50	=	0.1	n.a.	PMID[20079560]
NPT3929	Protein Complex	Glutamate NMDA receptor; GRIN1/GRIN2A	Homo sapiens	Activity	=	25.4	%	PMID[20361801]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	4.966	nM	PMID[20361801]
NPT3930	Protein Complex	Glutamate NMDA receptor; GRIN1/GRIN2B	Homo sapiens	Activity	=	86.6	%	PMID[20361801]
NPT3929	Protein Complex	Glutamate NMDA receptor; GRIN1/GRIN2A	Homo sapiens	IC50	=	4900.0	nM	PMID[20361801]
NPT3930	Protein Complex	Glutamate NMDA receptor; GRIN1/GRIN2B	Homo sapiens	IC50	=	44000.0	nM	PMID[20361801]
NPT2	Others	Unspecified		Ratio IC50	=	0.1	n.a.	PMID[20361801]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	5.0	nM	PMID[20361801]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	19.0	nM	PMID[20472431]
NPT2	Others	Unspecified		Ratio IC50	=	9.11	n.a.	PMID[20472431]
NPT2	Others	Unspecified		IC50	=	193.0	nM	PMID[20575555]
NPT914	Individual Protein	Acetylcholinesterase	Bos taurus	Inhibition	=	4.0	%	PMID[20575555]
NPT914	Individual Protein	Acetylcholinesterase	Bos taurus	IC50	=	27.0	nM	PMID[20575555]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	5.2	nM	PMID[20575555]
NPT2	Others	Unspecified		Ratio IC50	=	4.0	n.a.	PMID[20545360]
NPT914	Individual Protein	Acetylcholinesterase	Bos taurus	IC50	=	40.0	nM	PMID[20545360]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	10.0	nM	PMID[20545360]
NPT3768	Others	Cholinesterases; ACHE & BCHE	Homo sapiens	Ratio IC50	=	0.1	n.a.	PMID[20545360]
NPT35	Others	n.a.		IC50	<	0.01	nM	PMID[20545360]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	194.7	%	PMID[20684567]
NPT3768	Others	Cholinesterases; ACHE & BCHE	Homo sapiens	Ratio IC50	=	0.05	n.a.	PMID[20817518]
NPT2	Others	Unspecified		Ratio IC50	=	0.13	n.a.	PMID[20880702]
NPT27	Others	Unspecified		EC50	>	50000.0	nM	PMID[20547819]
NPT580	Organism	Trypanosoma cruzi	Trypanosoma cruzi	EC50	=	24000.0	nM	PMID[20547819]
NPT2	Others	Unspecified		Ratio EC50	>	2.1	n.a.	PMID[20547819]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	4.898	nM	PMID[20926161]
NPT914	Individual Protein	Acetylcholinesterase	Bos taurus	IC50	=	40.0	nM	PMID[20926162]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	10.0	nM	PMID[20926162]
NPT914	Individual Protein	Acetylcholinesterase	Bos taurus	IC50	=	109.0	nM	PMID[21163662]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	5.2	nM	PMID[21163662]
NPT2	Others	Unspecified		Ratio IC50	=	0.19	n.a.	PMID[21163662]
NPT2	Others	Unspecified		Ratio IC50	=	7.1	n.a.	PMID[21211982]
NPT2	Others	Unspecified		Ratio IC50	=	0.193	n.a.	PMID[21111515]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	5.2	nM	PMID[21111515]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	6.4	nM	PMID[21232964]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	6.383	nM	PMID[21232964]
NPT2	Others	Unspecified		Ratio IC50	=	7.3	n.a.	PMID[21232964]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	5.2	nM	PMID[21411323]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	11.0	nM	PMID[21367493]
NPT2	Others	Unspecified		Ratio IC50	=	0.1	n.a.	PMID[21367493]
NPT3768	Others	Cholinesterases; ACHE & BCHE	Homo sapiens	Ratio IC50	=	0.15	n.a.	PMID[21435752]
NPT2	Others	Unspecified		Ratio IC50	=	0.008	n.a.	PMID[21570751]
NPT2	Others	Unspecified		Ratio IC50	=	118.63	n.a.	PMID[21570751]
NPT2	Others	Unspecified		Ratio IC50	=	0.2	n.a.	PMID[21798635]
NPT2	Others	Unspecified		Ratio IC50	=	0.2	n.a.	PMID[21871694]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	21.0	nM	PMID[21871694]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	21.0	nM	PMID[21873056]
NPT2	Others	Unspecified		Ratio IC50	=	3.4	n.a.	PMID[21873056]
NPT3768	Others	Cholinesterases; ACHE & BCHE	Homo sapiens	Ratio IC50	=	0.05	n.a.	PMID[21920739]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	41.0	nM	PMID[22019228]
NPT2	Others	Unspecified		Ratio IC50	=	0.13	n.a.	PMID[22019228]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	5.2	nM	PMID[22000936]
NPT2	Others	Unspecified		Ratio IC50	=	0.193	n.a.	PMID[22000936]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	10.0	nM	PMID[21420206]
NPT914	Individual Protein	Acetylcholinesterase	Bos taurus	IC50	=	40.0	nM	PMID[21420206]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	21.0	nM	PMID[22341944]
NPT2	Others	Unspecified		Ratio IC50	=	0.2	n.a.	PMID[22341944]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	14.0	nM	PMID[22444876]
NPT2	Others	Unspecified		Ratio IC50	=	0.15	n.a.	PMID[22444876]
NPT914	Individual Protein	Acetylcholinesterase	Bos taurus	Inhibition	=	16.2	%	PMID[22185619]
NPT2	Others	Unspecified		Inhibition	=	5.6	%	PMID[22185619]
NPT3768	Others	Cholinesterases; ACHE & BCHE	Homo sapiens	Ratio IC50	=	13.0	n.a.	PMID[22185619]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	Ratio	<	0.01	n.a.	PMID[22243648]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	10.0	nM	PMID[22243648]
NPT914	Individual Protein	Acetylcholinesterase	Bos taurus	IC50	=	40.0	nM	PMID[22243648]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	41.0	nM	PMID[22472046]
NPT2	Others	Unspecified		Ratio IC50	=	0.13	n.a.	PMID[22472046]
NPT2	Others	Unspecified		Ratio IC50	=	0.19	n.a.	PMID[22503231]
NPT2	Others	Unspecified		Ratio IC50	>	2.5	n.a.	PMID[22503231]
NPT2	Others	Unspecified		Ratio IC50	=	0.11	n.a.	PMID[22503231]
NPT2	Others	Unspecified		Inhibition	<	10.0	%	PMID[22503231]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	3.802	nM	PMID[22420827]
NPT3749	Tissue	Hippocampus	Rattus norvegicus	Activity	=	136.2	%	PMID[22420827]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	5.2	nM	PMID[21715067]
NPT2	Others	Unspecified		Ratio IC50	=	0.193	n.a.	PMID[21715067]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	13.0	nM	PMID[22633691]
NPT2	Others	Unspecified		Ratio IC50	=	0.2	n.a.	PMID[22633691]
NPT433	Subcellular	Liver microsomes	Homo sapiens	Activity	=	201.0	pmol	PMID[22931300]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	15.8	nM	PMID[22944335]
NPT2	Others	Unspecified		Ratio IC50	=	0.14	n.a.	PMID[22944335]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	100.0	nM	PMID[22981331]
NPT1	Others	Radical scavenging activity		IC50	>	1000000.0	nM	PMID[22981331]
NPT2	Others	Unspecified		Inhibition	=	22.8	%	PMID[22981331]
NPT2	Others	Unspecified		Inhibition	=	22.1	%	PMID[22981331]
NPT2	Others	Unspecified		Ratio IC50	=	0.1	n.a.	PMID[22981331]
NPT2	Others	Unspecified		IC50	=	1200.0	nM	PMID[21599003]
NPT27	Others	Unspecified		Ratio	=	0.11	n.a.	PMID[21599003]
NPT27	Others	Unspecified		Ratio	=	0.07	n.a.	PMID[21599003]
NPT27	Others	Unspecified		Ratio	=	0.001	n.a.	PMID[21599003]
NPT2	Others	Unspecified		Ratio IC50	=	17.0	n.a.	PMID[23000296]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	3.802	nM	PMID[23000296]
NPT3768	Others	Cholinesterases; ACHE & BCHE	Homo sapiens	Ratio Ki	=	0.27	n.a.	PMID[23041347]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	140.0	%	PMID[22624880]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	15.0	%	PMID[22624880]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	10.0	%	PMID[22624880]
NPT2	Others	Unspecified		Ratio IC50	=	4.9	n.a.	PMID[22624880]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	5.129	nM	PMID[22624880]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	3.2	nM	PMID[22624880]
NPT27	Others	Unspecified		Activity	=	25.0	%	PMID[22795665]
NPT2	Others	Unspecified		EC50	=	1330.0	nM	PMID[22795665]
NPT2	Others	Unspecified		Activity	=	37.65	%	PMID[22795665]
NPT2	Others	Unspecified		Activity	=	48.14	%	PMID[22795665]
NPT2	Others	Unspecified		Activity	=	58.18	%	PMID[22795665]
NPT2	Others	Unspecified		Activity	=	53.01	%	PMID[22795665]
NPT2	Others	Unspecified		Activity	=	62.9	%	PMID[22795665]
NPT2	Others	Unspecified		Activity	=	65.95	%	PMID[22795665]
NPT2	Others	Unspecified		Activity	=	65.65	%	PMID[22795665]
NPT2	Others	Unspecified		Activity	=	46.62	%	PMID[22795665]
NPT2	Others	Unspecified		Activity	=	40.24	%	PMID[22795665]
NPT35	Others	n.a.		Activity	<	0.01	equiv	PMID[22795665]
NPT27	Others	Unspecified		Activity	=	98.45	%	DOI[10.1007/s00044-011-9695-0]
NPT27	Others	Unspecified		Activity	=	96.59	%	DOI[10.1007/s00044-011-9695-0]
NPT27	Others	Unspecified		Activity	=	100.73	%	DOI[10.1007/s00044-011-9695-0]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	54.91	%	DOI[10.1007/s00044-012-0403-5]
NPT2	Others	Unspecified		Ratio IC50	=	0.6	n.a.	PMID[23273608]
NPT2	Others	Unspecified		IC50	=	137.0	nM	PMID[23273608]
NPT2	Others	Unspecified		Ratio IC50	=	0.2	n.a.	PMID[23454517]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	21.6	nM	PMID[23454517]
NPT2	Others	Unspecified		Ratio IC50	=	0.3	n.a.	PMID[23501115]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	33.4	nM	PMID[23501115]
NPT177	Tissue	Aorta	Rattus norvegicus	Activity	=	3.4	%	PMID[23639542]
NPT35	Others	n.a.		Activity	=	0.011	ug ml-1	PMID[23639542]
NPT2	Others	Unspecified		Ratio IC50	=	6.6	n.a.	PMID[23639542]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	10.6	nM	PMID[23639542]
NPT2	Others	Unspecified		Ratio IC50	=	0.2	n.a.	PMID[23511019]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	54.0	nM	PMID[23511019]
NPT2	Others	Unspecified		Ratio IC50	=	0.156	n.a.	PMID[23685572]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	42.0	nM	PMID[23685572]
NPT1	Others	Radical scavenging activity		EC50	>	1000000.0	nM	PMID[23768661]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	9.8	nM	PMID[23891231]
NPT2	Others	Unspecified		Ratio IC50	=	0.08	n.a.	PMID[23988412]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	32.0	nM	PMID[23988412]
NPT2	Others	Unspecified		Ratio IC50	=	0.2	n.a.	PMID[24095756]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	50.0	nM	PMID[24095756]
NPT78	Individual Protein	Beta amyloid A4 protein	Homo sapiens	Inhibition	<	5.0	%	PMID[24140444]
NPT2	Others	Unspecified		Ratio IC50	=	0.13	n.a.	PMID[24160297]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	15.0	nM	PMID[24160297]
NPT2	Others	Unspecified		Ratio IC50	=	0.17	n.a.	PMID[24128814]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	19.2	nM	PMID[24128814]
NPT2	Others	Unspecified		Ratio IC50	=	0.14	n.a.	PMID[24220172]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	15.8	nM	PMID[24220172]
NPT2	Others	Unspecified		Ratio IC50	=	0.2	n.a.	PMID[24148835]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	47.0	nM	PMID[24148835]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	15.0	nM	PMID[24461494]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	89.2	nmol/g	PMID[24594525]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	87.4	nmol/g	PMID[24594525]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	1800.0	ug/g	PMID[24594525]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	1821.0	ug/g	PMID[24594525]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	171.0	ug/g	PMID[24594525]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	170.0	ug/g	PMID[24594525]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	1457.0	ug/g	PMID[24594525]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	1480.0	ug/g	PMID[24594525]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	0.61	g	PMID[24594525]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	0.65	g	PMID[24594525]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	154.0	nmol/g	PMID[24594525]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	123.0	nmol/g	PMID[24594525]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	822.0	ug/g	PMID[24594525]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	824.0	ug/g	PMID[24594525]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	75.6	ug/g	PMID[24594525]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	79.9	ug/g	PMID[24594525]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	671.0	ug/g	PMID[24594525]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	665.0	ug/g	PMID[24594525]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	1.82	g	PMID[24594525]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	1.77	g	PMID[24594525]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	100.0	pmol/mg.min	PMID[24594525]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	134.0	pmol/mg.min	PMID[24594525]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	197.0	pmol/mg.min	PMID[24594525]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	207.0	pmol/mg.min	PMID[24594525]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	0.44	nmol/mg.min	PMID[24594525]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	0.6	nmol/mg.min	PMID[24594525]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	65.5	mg/ml	PMID[24594525]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	61.8	mg/ml	PMID[24594525]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	62.0	nmol/g	PMID[24594525]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	63.8	nmol/g	PMID[24594525]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	3173.0	ug/g	PMID[24594525]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	3378.0	ug/g	PMID[24594525]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	431.0	ug/g	PMID[24594525]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	418.0	ug/g	PMID[24594525]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	2310.0	ug/g	PMID[24594525]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	2542.0	ug/g	PMID[24594525]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	6.2	g	PMID[24594525]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	6.8	g	PMID[24594525]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	219.0	g	PMID[24594525]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	228.0	g	PMID[24594525]
NPT2	Others	Unspecified		Ratio IC50	=	0.2	n.a.	PMID[24508831]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	54.13	%	PMID[24508831]
NPT2	Others	Unspecified		IC50	=	220.0	nM	PMID[24508831]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	IC50	>	100000.0	nM	PMID[24508831]
NPT2	Others	Unspecified		Ratio IC50	=	0.25	n.a.	DOI[10.1039/C3MD00376K]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	52.0	nM	DOI[10.1039/C3MD00376K]
NPT67	Individual Protein	Cholinesterase	Equus caballus	Inhibition	=	100.0	%	DOI[10.1039/C2MD20063E]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	2.43	nM	DOI[10.1039/C2MD20063E]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	3.3	nM	PMID[24657052]
NPT2	Others	Unspecified		Ratio IC50	=	0.55	n.a.	PMID[24657052]
NPT2	Others	Unspecified		IC50	=	40.0	nM	PMID[24738476]
NPT2	Others	Unspecified		IC50	=	42.95	nM	PMID[24836068]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	6.95	nM	PMID[24836068]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	10.0	nM	PMID[24858540]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	37.0	nM	PMID[24794747]
NPT2	Others	Unspecified		Ratio IC50	=	5.8	n.a.	PMID[24794747]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	4.0	nM	PMID[24835788]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	350.0	nM	PMID[25462245]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	3.7	nM	PMID[25047936]
NPT3768	Others	Cholinesterases; ACHE & BCHE	Homo sapiens	Ratio Ki	=	0.24	n.a.	PMID[25088549]
NPT2	Others	Unspecified		Ratio IC50	=	0.046	n.a.	PMID[25089370]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	3.664	nM	PMID[25047936]
NPT2	Others	Unspecified		Ratio IC50	=	0.2	n.a.	PMID[25047936]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	4.0	nM	PMID[25017625]
NPT2	Others	Unspecified		Ratio IC50	=	0.14	n.a.	PMID[25282266]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	50.5	nM	PMID[25282654]
NPT2	Others	Unspecified		Ratio IC50	=	0.2	n.a.	PMID[25282654]
NPT2	Others	Unspecified		Ratio IC50	=	8.6	n.a.	PMID[25226236]
NPT3768	Others	Cholinesterases; ACHE & BCHE	Homo sapiens	Ratio IC50	=	0.05	n.a.	PMID[25259726]
NPT78	Individual Protein	Beta amyloid A4 protein	Homo sapiens	Inhibition	<	5.0	%	PMID[25259726]
NPT2	Others	Unspecified		Ratio IC50	=	6.6	n.a.	PMID[25597004]
NPT2	Others	Unspecified		Ratio IC50	=	0.4	n.a.	PMID[25597007]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	40.0	nM	PMID[25597007]
NPT35	Others	n.a.		Inhibition	>	1000.0	%	PMID[25597007]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	2.0	nM	PMID[25707322]
NPT2	Others	Unspecified		Ratio IC50	<	0.1	n.a.	PMID[25707322]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	8130.0	nM	PMID[25868744]
NPT2	Others	Unspecified		Ratio IC50	=	0.31	n.a.	PMID[25656088]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	35.2	nM	PMID[25656088]
NPT2	Others	Unspecified		Ratio IC50	=	0.05	n.a.	PMID[25656088]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	20.19	nM	PMID[25812965]
NPT2	Others	Unspecified		Ratio IC50	=	0.21	n.a.	PMID[25812965]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	2.0	nM	PMID[25621991]
NPT2	Others	Unspecified		Ratio IC50	=	0.06	n.a.	PMID[25812965]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	350.0	nM	PMID[25969170]
NPT2	Others	Unspecified		Ratio IC50	=	1.25	n.a.	PMID[25969170]
NPT712	Individual Protein	Bile salt export pump	Rattus norvegicus	IC50	>	1000000.0	nM	PMID[21965623]
NPT713	Individual Protein	Bile salt export pump	Homo sapiens	IC50	>	1000000.0	nM	PMID[21965623]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	4.7	nM	PMID[26242241]
NPT2	Others	Unspecified		Ratio IC50	=	0.04	n.a.	PMID[26242241]
NPT2	Others	Unspecified		Ratio IC50	=	26.96	n.a.	PMID[26242241]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	4.4	nM	PMID[26278660]
NPT3929	Protein Complex	Glutamate NMDA receptor; GRIN1/GRIN2A	Homo sapiens	IC50	=	4900.0	nM	PMID[26278660]
NPT3930	Protein Complex	Glutamate NMDA receptor; GRIN1/GRIN2B	Homo sapiens	IC50	=	44000.0	nM	PMID[26278660]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	820.0	nM	PMID[26212777]
NPT3768	Others	Cholinesterases; ACHE & BCHE	Homo sapiens	Ratio IC50	=	0.68	n.a.	PMID[26503905]
NPT35	Others	n.a.		EC50	>	100000.0	nM	PMID[26503905]
NPT2	Others	Unspecified		Ratio IC50	=	4.75	n.a.	PMID[26588065]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	1770.0	nM	PMID[26588065]
NPT27	Others	Unspecified		Inhibition	=	10.24	%	PMID[26752094]
NPT27	Others	Unspecified		Inhibition	=	4.62	%	PMID[26752094]
NPT3768	Others	Cholinesterases; ACHE & BCHE	Homo sapiens	Ratio IC50	=	0.108	n.a.	PMID[26632651]
NPT78	Individual Protein	Beta amyloid A4 protein	Homo sapiens	Inhibition	<	5.0	%	PMID[26632651]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	32.5	%	PMID[26632651]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	62.7	U/L	PMID[26632651]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	65.7	U/L	PMID[26632651]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	55.4	U/L	PMID[26632651]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	170.4	U/L	PMID[26632651]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	151.6	U/L	PMID[26632651]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	138.1	U/L	PMID[26632651]
NPT32	Organism	Mus musculus	Mus musculus	FC	=	1.6	n.a.	PMID[26632651]
NPT32	Organism	Mus musculus	Mus musculus	FC	=	1.5	n.a.	PMID[26632651]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	20.0	nM	PMID[26917219]
NPT2	Others	Unspecified		Ratio IC50	=	0.18	n.a.	PMID[26917219]
NPT2	Others	Unspecified		Ratio IC50	=	4.0	n.a.	DOI[10.1039/C5MD00274E]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	5.2	nM	PMID[27083471]
NPT2	Others	Unspecified		Ratio IC50	=	0.2	n.a.	PMID[27083471]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	14.45	nM	PMID[27061983]
NPT2	Others	Unspecified		Ratio IC50	=	0.2	n.a.	PMID[27061983]
NPT78	Individual Protein	Beta amyloid A4 protein	Homo sapiens	IC50	=	12.21	nM	PMID[27061983]
NPT757	Organism	Plasmodium falciparum 3D7	Plasmodium falciparum 3D7	IC50	=	12500.0	nM	PMID[27316542]
NPT27	Others	Unspecified		IC50	>	100000.0	nM	PMID[27316542]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	10.0	nM	PMID[27328658]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	50.0	nM	PMID[27460699]
NPT2	Others	Unspecified		Ratio IC50	=	0.22	n.a.	PMID[27460699]
NPT3768	Others	Cholinesterases; ACHE & BCHE	Homo sapiens	Ratio IC50	=	0.07	n.a.	PMID[27460699]
NPT2	Others	Unspecified		Ratio IC50	=	0.4	n.a.	PMID[27227482]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	54.0	nM	PMID[27227482]
NPT2	Others	Unspecified		Ratio IC50	=	0.2	n.a.	PMID[27392529]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	37.08	nM	PMID[27343850]
NPT2	Others	Unspecified		Ratio IC50	=	0.19	n.a.	PMID[27343850]
NPT35	Others	n.a.		Activity	<	0.1	equiv	PMID[27343850]
NPT78	Individual Protein	Beta amyloid A4 protein	Homo sapiens	Inhibition	=	5.6	%	PMID[27343850]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	1.2	nM	PMID[27376495]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	>	25.0	%	PMID[27376495]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	Activity	=	64.3	%	PMID[27376495]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	46.0	nM	PMID[27484514]
NPT2	Others	Unspecified		Ratio IC50	=	0.211	n.a.	PMID[27484514]
NPT2	Others	Unspecified		Ratio IC50	=	0.089	n.a.	PMID[27484514]
NPT2	Others	Unspecified		Ratio IC50	=	18.4	n.a.	PMID[27484515]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	Activity	=	56.0	%	PMID[27484515]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	Activity	=	74.6	%	PMID[27484515]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	Activity	=	64.2	%	PMID[27484515]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	Activity	=	89.0	%	PMID[27484515]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	Activity	=	40.8	%	PMID[27484515]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	Activity	=	70.1	%	PMID[27484515]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	Activity	=	92.9	%	PMID[27484515]
NPT2	Others	Unspecified		Ratio IC50	=	5.0	n.a.	PMID[27908752]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	2.0	nM	PMID[27560283]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	2.0	nM	PMID[27721153]
NPT35	Others	n.a.		Activity	=	0.2	equiv	PMID[27918993]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	0.05	nM	PMID[27918993]
NPT78	Individual Protein	Beta amyloid A4 protein	Homo sapiens	Inhibition	<	5.0	%	PMID[28064079]
NPT713	Individual Protein	Bile salt export pump	Homo sapiens	IC50	>	135000.0	nM	PMID[20829430]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	3.2	nM	PMID[28613859]
NPT713	Individual Protein	Bile salt export pump	Homo sapiens	IC50	>	1000000.0	nM	PMID[22961681]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	16.0	nM	PMID[28454848]
NPT2	Others	Unspecified		Ratio IC50	=	0.15	n.a.	PMID[28454848]
NPT713	Individual Protein	Bile salt export pump	Homo sapiens	IC50	>	133000.0	nM	PMID[23956101]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	50.0	nM	PMID[28302511]
NPT2	Others	Unspecified		Ratio IC50	=	2.1	n.a.	PMID[28302511]
NPT35	Others	n.a.		Activity	=	0.3	equiv	PMID[28302511]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	17.0	nM	PMID[27744252]
NPT2	Others	Unspecified		Ratio IC50	=	0.17	n.a.	PMID[27744252]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	10.0	nM	PMID[27863370]
NPT2	Others	Unspecified		Ratio IC50	=	0.29	n.a.	PMID[27863370]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	29.0	nM	PMID[28986116]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	29.0	nM	PMID[28578994]
NPT35	Others	n.a.		Activity	=	0.02	equiv	PMID[28578994]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	IC50	=	14600.0	nM	PMID[28698054]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	IC50	=	18400.0	nM	PMID[28698054]
NPT20763	CELL-LINE	J774.1	Mus musculus	IC50	>	100000.0	nM	PMID[28698054]
NPT2	Others	Unspecified		Ratio IC50	>	6.8	n.a.	PMID[28698054]
NPT3768	Others	Cholinesterases; ACHE & BCHE	Homo sapiens	Ratio IC50	=	9.22	n.a.	PMID[29031067]
NPT78	Individual Protein	Beta amyloid A4 protein	Homo sapiens	Inhibition	<	5.0	%	PMID[29031067]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	56.0	nM	PMID[28478343]
NPT2	Others	Unspecified		Ratio IC50	=	0.25	n.a.	PMID[28478343]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	5.0	nM	PMID[28734245]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	24.27	nM	PMID[29268129]
NPT2	Others	Unspecified		Ratio IC50	=	5.9	n.a.	PMID[29268129]
NPT78	Individual Protein	Beta amyloid A4 protein	Homo sapiens	Inhibition	=	5.6	%	PMID[29268129]
NPT67	Individual Protein	Cholinesterase	Equus caballus	Inhibition	=	57.08	%	PMID[29268129]
NPT21742	CELL-LINE	L02	Homo sapiens	Activity	=	19.8	%	PMID[29268129]
NPT32	Organism	Mus musculus	Mus musculus	FC	=	1.5	n.a.	PMID[29268129]
NPT32	Organism	Mus musculus	Mus musculus	FC	=	1.3	n.a.	PMID[29268129]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	3.2	nM	PMID[29324339]
NPT2	Others	Unspecified		Ratio IC50	=	0.17	n.a.	PMID[29353726]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	14.98	nM	PMID[29353726]
NPT2	Others	Unspecified		Ratio IC50	=	6.0	n.a.	PMID[29353726]
NPT78	Individual Protein	Beta amyloid A4 protein	Homo sapiens	Inhibition	=	7.7	%	PMID[29857276]
NPT67	Individual Protein	Cholinesterase	Equus caballus	Ki	=	17.2	nM	PMID[28728108]
NPT2	Others	Unspecified		Ratio Ki	=	0.7	n.a.	PMID[28728108]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	13.0	nM	PMID[28803044]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	14.0	nM	PMID[28810188]
NPT3768	Others	Cholinesterases; ACHE & BCHE	Homo sapiens	Ratio IC50	=	7.08	n.a.	PMID[28923380]
NPT78	Individual Protein	Beta amyloid A4 protein	Homo sapiens	Inhibition	=	4.03	%	PMID[28923380]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	7.2	nM	PMID[29466774]
NPT78	Individual Protein	Beta amyloid A4 protein	Homo sapiens	Inhibition	=	20.0	%	PMID[29466775]
NPT35	Others	n.a.		EC50	>	1000000.0	nM	PMID[29466775]
NPT2	Others	Unspecified		Ratio IC50	=	0.275	n.a.	PMID[29533874]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	33.4	U/L	PMID[29475581]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	35.9	U/L	PMID[29475581]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	33.7	U/L	PMID[29475581]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	101.1	U/L	PMID[29475581]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	97.6	U/L	PMID[29475581]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	82.5	U/L	PMID[29475581]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	29.0	nM	PMID[30104121]
NPT78	Individual Protein	Beta amyloid A4 protein	Homo sapiens	Inhibition	=	7.7	%	PMID[30190181]
NPT2	Others	Unspecified		Ratio IC50	=	0.17	n.a.	PMID[29541355]
NPT78	Individual Protein	Beta amyloid A4 protein	Homo sapiens	Inhibition	<	5.0	%	PMID[29541355]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	32.0	U/L	PMID[29541355]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	25.0	U/L	PMID[29541355]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	130.0	U/L	PMID[29541355]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	120.0	U/L	PMID[29541355]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	110.0	U/L	PMID[29541355]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	2.692	nM	PMID[30108847]
NPT2	Others	Unspecified		Ratio IC50	=	0.11	n.a.	PMID[30108842]
NPT78	Individual Protein	Beta amyloid A4 protein	Homo sapiens	Inhibition	<	5.0	%	PMID[30108842]
NPT67	Individual Protein	Cholinesterase	Equus caballus	Inhibition	=	99.63	%	PMID[30108908]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	66.0	nM	PMID[30108908]
NPT2	Others	Unspecified		Ratio IC50	=	0.17	n.a.	PMID[30245401]
NPT2	Others	Unspecified		Ratio IC50	=	1.8	n.a.	PMID[30340901]
NPT3768	Others	Cholinesterases; ACHE & BCHE	Homo sapiens	Ratio IC50	=	5.0	n.a.	PMID[30031971]
NPT3768	Others	Cholinesterases; ACHE & BCHE	Homo sapiens	Ratio IC50	=	10.3	n.a.	PMID[30771604]
NPT2	Others	Unspecified		IC50	=	7870.0	nM	PMID[30771604]
NPT2	Others	Unspecified		EC100	=	2.11	uM	PMID[30771604]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	10.6	nM	PMID[30744931]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	40.0	nM	PMID[31136894]
NPT2	Others	Unspecified		Ratio IC50	=	7.0	n.a.	PMID[31136894]
NPT35	Others	n.a.		Inhibition	=	53.62	%	PMID[31136894]
NPT78	Individual Protein	Beta amyloid A4 protein	Homo sapiens	Inhibition	=	5.0	%	PMID[31609608]
NPT67	Individual Protein	Cholinesterase	Equus caballus	Ki	=	17.0	nM	PMID[31376562]
NPT2	Others	Unspecified		Ratio IC50	=	9.3	n.a.	PMID[31376562]
NPT78	Individual Protein	Beta amyloid A4 protein	Homo sapiens	Inhibition	<	5.0	%	PMID[31376562]
NPT2	Others	Unspecified		Ratio IC50	=	1.8	n.a.	PMID[32904099]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	1.53	nM	PMID[31669851]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	15.0	nM	PMID[31812794]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	216.0	nM	PMID[31281020]
NPT2	Others	Unspecified		Ratio IC50	=	1.96	n.a.	PMID[31281020]
NPT1509	Protein Complex	Cyclin-dependent kinase 5/CDK5 activator 1	Homo sapiens	IC50	>	10000.0	nM	PMID[30798053]
NPT22078	PROTEIN FAMILY	Glycogen synthase kinase-3	Sus scrofa	IC50	>	10000.0	nM	PMID[30798053]
NPT3768	Others	Cholinesterases; ACHE & BCHE	Homo sapiens	Ratio IC50	=	0.08	n.a.	PMID[30798053]
NPT78	Individual Protein	Beta amyloid A4 protein	Homo sapiens	Inhibition	<	5.0	%	PMID[30851693]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	2.0	nM	PMID[27445168]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	14.0	nM	PMID[27405689]
NPT19090	SINGLE PROTEIN	Gastrotropin	Homo sapiens	Kd	=	200000.0	nM	PMID[27500412]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	10.0	nM	PMID[27253679]
NPT2	Others	Unspecified		Ratio IC50	=	4.9	n.a.	PMID[27253679]
NPT35	Others	n.a.		Activity	=	54.9	%	PMID[27253679]
NPT35	Others	n.a.		Activity	=	68.8	%	PMID[27253679]
NPT20556	SINGLE PROTEIN	Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2	Inhibition	=	14.07	%	DOI[10.6019/CHEMBL4495564]
NPT20555	ORGANISM	SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2	Inhibition	=	0.13	%	DOI[10.6019/CHEMBL4495565]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	45.0	nM	PMID[31901382]
NPT2	Others	Unspecified		Ratio IC50	=	0.2	n.a.	PMID[31901382]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	8.0	nM	PMID[32150413]
NPT914	Individual Protein	Acetylcholinesterase	Bos taurus	IC50	=	180.0	nM	PMID[30739821]
NPT4902	Protein Complex	Voltage-gated calcium channel	Homo sapiens	IC50	=	17000.0	nM	PMID[30739821]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	4.28	m	PMID[32503694]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	4.63	n.a.	PMID[32503694]
NPT2	Others	Unspecified		Ratio IC50	>	1.27	n.a.	PMID[32165042]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	110.0	nM	PMID[32165042]
NPT2	Others	Unspecified		Ratio IC50	=	2.27	n.a.	PMID[32165042]
NPT20555	ORGANISM	SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2	IC50	>	20000.0	nM	DOI[10.6019/CHEMBL4651402]
NPT20555	ORGANISM	SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2	IC50	>	19952.62	nM	DOI[10.6019/CHEMBL4651402]
NPT2	Others	Unspecified		Inhibition	=	11.0	%	PMID[33120080]
NPT2	Others	Unspecified		Inhibition	=	7.0	%	PMID[33120080]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	5.07	nM	PMID[27736061]
NPT2	Others	Unspecified		Ratio IC50	=	16.8	n.a.	PMID[27736061]
NPT35	Others	n.a.		Activity	<	0.01	equiv	PMID[27736061]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	30.0	nM	PMID[33039562]
NPT67	Individual Protein	Cholinesterase	Equus caballus	IC50	=	54.0	nM	PMID[27157006]
NPT2	Others	Unspecified		Ratio IC50	=	0.4	n.a.	PMID[27157006]
NPT78	Individual Protein	Beta amyloid A4 protein	Homo sapiens	Inhibition	<	10.0	%	PMID[32706255]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	2.4	n.a.	PMID[33189440]
NPT67	Individual Protein	Cholinesterase	Equus caballus	Inhibition	=	100.0	%	PMID[32380385]
NPT67	Individual Protein	Cholinesterase	Equus caballus	Inhibition	=	99.7	%	PMID[32380385]

☑ Note for Activity Records:
☉ The quantitative biological activities were primarily integrated from ChEMBL (Version-30) database and were also directly collected from PubMed literature. PubMed PMID was provided as the reference link for each activity record.

Chemically structural similarity: I. Similar Active Natural Products in NPASS

Top-200 similar NPs were calculated against the active-NP-set (includes 4,3285 NPs with experimentally-derived bioactivity available in NPASS)

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient

● The left chart: Distribution of similarity level between NPC479379 and all remaining natural products in the NPASS database.
● The right table: Most similar natural products (Tc>=0.56 or Top200).

range	Tanimoto Coefficient
0-0.1	1123
0.1-0.2	13202
0.2-0.3	17067
0.3-0.4	5940
0.4-0.5	2359
0.5-0.6	1658
0.6-0.7	939
0.7-0.8	318
0.8-0.85	62
0.85-0.9	22
0.9-0.95	5
0.95-1	2

Similarity Score	Similarity Level	Natural Product ID

Chemically structural similarity: II. Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

● The left chart: Distribution of similarity level between NPC479379 and all drugs/candidates.
● The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).

range	Tanimoto Coefficient
0-0.1	488
0.1-0.2	917
0.2-0.3	968
0.3-0.4	1984
0.4-0.5	2381
0.5-0.6	1712
0.6-0.7	560
0.7-0.8	115
0.8-0.85	21
0.85-0.9	2
0.9-0.95	0
0.95-1	2

Similarity Score	Similarity Level	Drug ID	Developmental Stage

Bioactivity similarity: Similar Natural Products in NPASS

Bioactivity similarity was calculated based on bioactivity descriptors of compounds. The bioactivity descriptors were calculated by a recently developed AI algorithm Chemical Checker (CC) [Nature Biotechnology, 38:1087–1096, 2020; Nature Communications, 12:3932, 2021], which evaluated bioactivity similarities at five levels:
☉ A: chemistry similarity;
☉ B: biological targets similarity;
☉ C: networks similarity;
☉ D: cell-based bioactivity similarity;
☉ E: similarity based on clinical data.

Those 5 categories of CC bioactivity descriptors were calculated and then subjected to manifold projection using UMAP algorithm, to project all NPs on a 2-Dimensional space. The current NP was highlighted with a small circle in the 2-D map. Below figures: left-to-right, A-to-E.

A: chemistry similarity

B: biological targets similarity

C: networks similarity

D: cell-based bioactivity similarity

E: similarity based on clinical data