NPASS Compound

Natural Product: NPC478931

Natural Product ID	NPC478931
Common Name ? The InCHIKey will be temporarily assigned as the "Common Name" if no IUPAC name or alternative short name is available.	PQLXHQMOHUQAKB-UHFFFAOYSA-N
IUPAC Name	n.a.
Synonyms
Synthetic Gene Cluster	n.a.
ChEMBL Identifier	n.a.
PubChem CID	3599
Chemical Classification	CHEMONTID:0000000 [Organic compounds] [CHEMONTID:0004707] Organic nitrogen compounds [CHEMONTID:0000278] Organonitrogen compounds [CHEMONTID:0000503] Quaternary ammonium salts [CHEMONTID:0001012] Cholines [CHEMONTID:0001250] Phosphocholines

The Chemical Classification was calculated by Classyfire, a software for chemical taxonomy calculation. Reference: DOI:10.1186/s13321-016-0174-y.

Chemical Representations

RDKit 3D 73 72 0 0 0 0 0 0 0 0999 V2000 -8.2373 3.2457 -0.2483 C 0 0 0 0 0 0 0 0 0 0 0 0 -8.2979 2.0105 -1.0911 C 0 0 0 0 0 0 0 0 0 0 0 0 -7.5489 0.8532 -0.3556 C 0 0 0 0 0 0 0 0 0 0 0 0 -7.6526 -0.3107 -1.2394 C 0 0 0 0 0 0 0 0 0 0 0 0 -7.1627 -1.6347 -0.9253 C 0 0 0 0 0 0 0 0 0 0 0 0 -5.8126 -2.0641 -0.6436 C 0 0 0 0 0 0 0 0 0 0 0 0 -4.9823 -1.7234 0.4847 C 0 0 0 0 0 0 0 0 0 0 0 0 -4.5121 -0.3906 0.8456 C 0 0 0 0 0 0 0 0 0 0 0 0 -3.7163 0.3458 -0.1455 C 0 0 0 0 0 0 0 0 0 0 0 0 -2.4709 -0.2127 -0.6871 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.2937 -0.5031 0.1509 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.3627 -1.5286 1.2208 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0546 -1.6878 1.8291 C 0 0 0 0 0 0 0 0 0 0 0 0 0.4724 -0.3720 2.4062 C 0 0 0 0 0 0 0 0 0 0 0 0 1.8460 -0.5546 3.0613 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8146 -0.9916 1.9888 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8343 0.0043 1.0243 O 0 0 0 0 0 0 0 0 0 0 0 0 3.9804 -0.3709 -0.1548 P 0 0 0 0 0 0 0 0 0 0 0 0 4.5506 -1.7332 0.1504 O 0 0 0 0 0 0 0 0 0 0 0 0 3.2567 -0.3875 -1.7006 O 0 0 0 0 0 1 0 0 0 0 0 0 5.1996 0.8081 -0.1785 O 0 0 0 0 0 0 0 0 0 0 0 0 6.4253 0.2282 -0.5910 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4558 1.3239 -0.5398 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7725 0.9484 -0.9209 N 0 0 0 0 0 4 0 0 0 0 0 0 9.1548 1.7264 -2.1061 C 0 0 0 0 0 0 0 0 0 0 0 0 9.7688 1.2698 0.0887 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8214 -0.4267 -1.3079 C 0 0 0 0 0 0 0 0 0 0 0 0 -7.3442 3.2284 0.4137 H 0 0 0 0 0 0 0 0 0 0 0 0 -8.1887 4.1758 -0.8857 H 0 0 0 0 0 0 0 0 0 0 0 0 -9.1645 3.3435 0.3507 H 0 0 0 0 0 0 0 0 0 0 0 0 -9.3272 1.6865 -1.3150 H 0 0 0 0 0 0 0 0 0 0 0 0 -7.7821 2.2002 -2.0544 H 0 0 0 0 0 0 0 0 0 0 0 0 -6.5256 1.2956 -0.2781 H 0 0 0 0 0 0 0 0 0 0 0 0 -7.9492 0.7568 0.6543 H 0 0 0 0 0 0 0 0 0 0 0 0 -7.3273 0.0426 -2.2824 H 0 0 0 0 0 0 0 0 0 0 0 0 -8.7927 -0.4300 -1.4348 H 0 0 0 0 0 0 0 0 0 0 0 0 -7.6182 -2.3175 -1.7745 H 0 0 0 0 0 0 0 0 0 0 0 0 -7.8718 -2.0482 -0.0686 H 0 0 0 0 0 0 0 0 0 0 0 0 -5.8672 -3.2375 -0.6313 H 0 0 0 0 0 0 0 0 0 0 0 0 -5.2328 -1.9647 -1.6451 H 0 0 0 0 0 0 0 0 0 0 0 0 -5.5553 -2.1023 1.4253 H 0 0 0 0 0 0 0 0 0 0 0 0 -4.0656 -2.4304 0.5683 H 0 0 0 0 0 0 0 0 0 0 0 0 -3.8791 -0.5117 1.7865 H 0 0 0 0 0 0 0 0 0 0 0 0 -5.3105 0.2910 1.2583 H 0 0 0 0 0 0 0 0 0 0 0 0 -4.3593 0.7878 -0.9749 H 0 0 0 0 0 0 0 0 0 0 0 0 -3.4031 1.3203 0.3894 H 0 0 0 0 0 0 0 0 0 0 0 0 -2.1093 0.5343 -1.4942 H 0 0 0 0 0 0 0 0 0 0 0 0 -2.6819 -1.1190 -1.3585 H 0 0 0 0 0 0 0 0 0 0 0 0 -0.3717 -0.6312 -0.4891 H 0 0 0 0 0 0 0 0 0 0 0 0 -1.0232 0.4830 0.7038 H 0 0 0 0 0 0 0 0 0 0 0 0 -1.9674 -1.2752 2.1109 H 0 0 0 0 0 0 0 0 0 0 0 0 -1.6953 -2.5244 0.8548 H 0 0 0 0 0 0 0 0 0 0 0 0 0.6756 -1.9526 0.9402 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0701 -2.5101 2.5437 H 0 0 0 0 0 0 0 0 0 0 0 0 -0.2546 0.0562 3.1036 H 0 0 0 0 0 0 0 0 0 0 0 0 0.6808 0.3513 1.5605 H 0 0 0 0 0 0 0 0 0 0 0 0 2.1178 0.4015 3.5139 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7212 -1.3322 3.8410 H 0 0 0 0 0 0 0 0 0 0 0 0 2.5569 -1.9861 1.6232 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8698 -1.0035 2.4144 H 0 0 0 0 0 0 0 0 0 0 0 0 6.5948 -0.5926 0.1162 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2334 -0.1568 -1.5946 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0906 2.1201 -1.2283 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5075 1.7257 0.4982 H 0 0 0 0 0 0 0 0 0 0 0 0 10.2568 1.6901 -2.2216 H 0 0 0 0 0 0 0 0 0 0 0 0 8.6111 1.3229 -2.9793 H 0 0 0 0 0 0 0 0 0 0 0 0 8.7627 2.7444 -1.9244 H 0 0 0 0 0 0 0 0 0 0 0 0 9.6007 2.3091 0.4173 H 0 0 0 0 0 0 0 0 0 0 0 0 10.7577 1.1796 -0.4105 H 0 0 0 0 0 0 0 0 0 0 0 0 9.7682 0.5916 0.9410 H 0 0 0 0 0 0 0 0 0 0 0 0 8.1264 -0.5820 -2.1577 H 0 0 0 0 0 0 0 0 0 0 0 0 8.4660 -1.0728 -0.4781 H 0 0 0 0 0 0 0 0 0 0 0 0 9.8419 -0.7298 -1.6494 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 2 3 1 0 3 4 1 0 4 5 1 0 5 6 1 0 6 7 1 0 7 8 1 0 8 9 1 0 9 10 1 0 10 11 1 0 11 12 1 0 12 13 1 0 13 14 1 0 14 15 1 0 15 16 1 0 16 17 1 0 17 18 1 0 18 19 2 0 18 20 1 0 18 21 1 0 21 22 1 0 22 23 1 0 23 24 1 0 24 25 1 0 24 26 1 0 24 27 1 0 1 28 1 0 1 29 1 0 1 30 1 0 2 31 1 0 2 32 1 0 3 33 1 0 3 34 1 0 4 35 1 0 4 36 1 0 5 37 1 0 5 38 1 0 6 39 1 0 6 40 1 0 7 41 1 0 7 42 1 0 8 43 1 0 8 44 1 0 9 45 1 0 9 46 1 0 10 47 1 0 10 48 1 0 11 49 1 0 11 50 1 0 12 51 1 0 12 52 1 0 13 53 1 0 13 54 1 0 14 55 1 0 14 56 1 0 15 57 1 0 15 58 1 0 16 59 1 0 16 60 1 0 22 61 1 0 22 62 1 0 23 63 1 0 23 64 1 0 25 65 1 0 25 66 1 0 25 67 1 0 26 68 1 0 26 69 1 0 26 70 1 0 27 71 1 0 27 72 1 0 27 73 1 0 M CHG 2 20 -1 24 1 M END

Standard InCHIKey	PQLXHQMOHUQAKB-UHFFFAOYSA-N
Standard InCHI	InChI=1S/C21H46NO4P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-20-25-27(23,24)26-21-19-22(2,3)4/h5-21H2,1-4H3
SMILES	CCCCCCCCCCCCCCCCOP(=O)([O-])OCC[N+](C)(C)C

Calculated Properties

Physi-Chem Properties

Molecular Weight:	407.32	Volume:	437.757 ? Van der Waals volume.
Dense:	0.93	LogP:	1.286 ? The logarithm of the n-octanol/water distribution coefficients.
logD7.4:	1.666 ? The logarithm of the n-octanol/water distribution coefficient at pH=7.4.	LogS:	-0.853 ? The logarithm of aqueous solubility value.
Rotatable Bonds:	20.0	Rigid Bonds:	1.0
TPSA:	58.59 ? Topological Polar Surface Area.	H-Bond Acceptor:	5.0
H-Bond Donor:	0.0	Rings:	0.0
Heavy Atoms:	6.0

MedChem Properties

QED Drug-Likeness Score:	0.148	GASA:	0.0 ? GASA represents the probability of being difficult to synthesize, ranging from 0 to 1.
Synthetic Accessibility Score:	3.322	Fsp³:	1.0
MCE-18:	6.0 ? MCE-18 stands for medicinal chemistry evolution.MCE-18≥45 is considered a suitable value.	Lipinski Rule-of-5:	Rejected
Pfizer Rule:	Rejected	GSK Rule:	Accepted
Golden Triangle Rule:	Rejected	BMS Rule:	1
Chelating Alert:	0	PAINS Alert:	0
Colloidal aggregators:	0.378	Fluc inhibitor:	0.0 ? The fluc inhibitor value is the probability of being fLuc inhibitors, within the range of 0 to 1.
Blue fluorescence:	0.005 ? The blue fluorescence value is the probability of being blue fluorescence, within the range of 0 to 1	Green fluorescence:	0.0 ? The green fluorescence value is the probability of being green fluorescence, within the range of 0 to 1
Reactive compounds:	0.266	Promiscuous compounds:	0.338

ADMET Properties (ADMETlab3.0)

ADMET: Absorption

Caco-2 Permeability:	-5.39	MDCK Permeability:	-4.749
Pgp-inhibitor:	0.001	Pgp-substrate:	0.0
PAMPA:	0.001 ? The experimental data for Peff was logarithmically transformed (logPeff). Molecules with log Peff values below 2.0 were classified as low-permeability (Category 0), while those with log Peff values exceeding 2.5 were classified as high-permeability (Category 1).	Human Intestinal Absorption (HIA):	0.917
20% Bioavailability (F20%):	0.563	30% Bioavailability (F30%):	0.997
50% Bioavailability (F50%):	0.994

ADMET: Distribution

Blood-Brain-Barrier Penetration (BBB):	0.0	MRP1:	0.932
Plasma Protein Binding (PPB):	97.525%	Volume Distribution (VD):	0.559
Fu:	2.357% ? The fraction unbound in plasms.	OATP1B1 inhibitor:	1.0
OATP1B3 inhibitor:	1.0	BCRP inhibitor:	0.133
BSEP inhibitor:	0.995

ADMET: Metabolism

CYP1A2-inhibitor:	0.0	CYP1A2-substrate:	1.0
CYP2C19-inhibitor:	0.993	CYP2C19-substrate:	0.009
CYP2C9-inhibitor:	0.987	CYP2C9-substrate:	0.0
CYP2D6-inhibitor:	0.59	CYP2D6-substrate:	0.662
CYP3A4-inhibitor:	0.0	CYP3A4-substrate:	1.0
CYP2B6-substrate:	0.0	CYP2C8-inhibitor:	0.979
HLM stability:	0.0 ? Human liver microsomal (HLM) stability. Category 0: stable+ (HLM > 30 min); Category 1: unstable- (HLM ≤ 30 min). The output value is the probability of human liver microsomal instability, where a value closer to 1 indicates a higher likelihood of instability.

ADMET: Excretion

Clearance (CL):

5.172

Half-life (T1/2):

0.784

ADMET: Toxicity

hERG Blockers:	0.074	hERG Blockers (10um):	0.322
Human Hepatotoxicity (H-HT):	0.995	Drug-induced Liver Injury (DILI):	0.051
AMES Toxicity:	0.019	Rat Oral Acute Toxicity:	0.764
Maximum Recommended Daily Dose:	0.998	Skin Sensitization:	1.0
Carcinogencity:	0.965	Eye Corrosion:	1.0
Eye Irritation:	1.0	Respiratory Toxicity:	0.999
Drug-induced Neurotoxicity:	0.225	Ototoxicity:	0.002
Hematotoxicity:	0.047	Drug-induced Nephrotoxicity:	1.0
Genotoxicity:	0.986	RPMI-8226 Immunitoxicity:	0.009
A549 Cytotoxicity:	0.0	Hek293 Cytotoxicity:	0.005
BCF:	0.846 ? Bioconcentration factors are used for considering secondary poisoning potential and assessing risks to human health via the food chain. The unit is -log10[(mg/L)/(1000*MW)].	IGC50:	4.367 ? 48 hour Tetrahymena pyriformis IGC50. The unit of IGC50 is -log10[(mg/L)/(1000*MW)].
LC50DM:	6.138 ? 48 hour Daphnia magna LC50. The unit of LC50DM is -log10[(mg/L)/(1000*MW)].	LC50FM:	3.407 ? 96 hour fathead minnow LC50. The unit of LC50FM is -log10[(mg/L)/(1000*MW)].

Species Source

Organism ID	Organism Name	Taxonomy Level	Family	SuperKingdom	Isolation Part	Collection Location	Collection Time	Reference
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	DOI[10.1016/0006-291X(79)91731-5]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	DOI[10.1093/emboj/18.8.2021]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[1091286]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[10977898]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[1100617]
NPO40017	Ancistrocladus ealaensis	Species	Ancistrocladaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[11087584]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[11745165]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[11750815]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[12369847]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[12467448]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[12805358]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	ChEBI[131529]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[13610867]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[13831814]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[14973046]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[15031653]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[15292242]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[15610037]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[1644759]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[16630633]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[170247]
NPO28537	Ancistrocladus abbreviatus	Species	Ancistrocladaceae	Eukaryota	n.a.	aerial part	n.a.	PMID[1766007]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[17765195]
NPO40426	Agelas oroides enoyl	Strain	Agelasidae	Eukaryota	Tubers	n.a.	n.a.	PMID[17765547]
NPO19278	Taxodium distichum	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[17869103]
NPO1848	Cussonia zimmermannii	Species	Araliaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[17922552]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[179975]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[19026742]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[19514719]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[19561621]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[21437340]
NPO24632	Salvia hydrangea	Species	Lamiaceae	Eukaryota	n.a.	aerial part	n.a.	PMID[21967089]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[21988831]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[22289691]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[22855027]
NPO15440	Chamaemelum nobile	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[23501116]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[23537328]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[23676670]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[241475]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[24206068]
NPO15440	Chamaemelum nobile	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[24471493]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[24783849]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[24831709]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[24939187]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[24966042]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[24967680]
NPO8987	Xenorhabdus nematophila	Species	Morganellaceae	Bacteria	n.a.	n.a.	n.a.	PMID[25080196]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[2543976]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[25867074]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[26195826]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[26337258]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[26670289]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[26826371]
NPO19278	Taxodium distichum	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[26905523]
NPO15440	Chamaemelum nobile	Species	Asteraceae	Eukaryota	Flowers	n.a.	n.a.	PMID[28116906]
NPO40018	Ancistrocladus ileboensis	Species	Ancistrocladaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[28121440]
NPO21618	Ircinia oros	Species	Irciniidae	Eukaryota	n.a.	n.a.	n.a.	PMID[28840725]
NPO40018	Ancistrocladus ileboensis	Species	Ancistrocladaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[29043798]
NPO40295	Plumarella delicatissima	Species	Primnoidae	Eukaryota	n.a.	n.a.	n.a.	PMID[29260557]
NPO40017	Ancistrocladus ealaensis	Species	Ancistrocladaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[29560715]
NPO40335	Salvia leriifolia	Species	Lamiaceae	Eukaryota	Roots	n.a.	n.a.	PMID[29896963]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[29897754]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[30302998]
NPO24632	Salvia hydrangea	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[30565934]
NPO40857	Helichrysum oocephalum	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[30916554]
NPO40017	Ancistrocladus ealaensis	Species	Ancistrocladaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[31630523]
NPO28537	Ancistrocladus abbreviatus	Species	Ancistrocladaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[31642313]
NPO41008	Photorhabdus temperata Meg1	Strain	Morganellaceae	Bacteria	n.a.	n.a.	n.a.	PMID[31799840]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[318639]
NPO40617	Streptomyces sp. ICBG1318	Strain	Streptomycetaceae	Bacteria	n.a.	n.a.	n.a.	PMID[32073851]
NPO28537	Ancistrocladus abbreviatus	Species	Ancistrocladaceae	Eukaryota	Roots	n.a.	n.a.	PMID[32125158]
NPO40100	Dendrilla antarctica	Species	Darwinellidae	Eukaryota	n.a.	n.a.	n.a.	PMID[32281798]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[3283102]
NPO24632	Salvia hydrangea	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[32973295]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[398096]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[4877125]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[4879561]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[4908789]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[5332408]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[6102982]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[6284709]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[6338507]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[7042909]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[7601837]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[8852895]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[9470222]
NPO15440	Chamaemelum nobile	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO21618	Ircinia oros	Species	Irciniidae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	Database[COCONUT]
NPO28537	Ancistrocladus abbreviatus	Species	Ancistrocladaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO40017	Ancistrocladus ealaensis	Species	Ancistrocladaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO19278	Taxodium distichum	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO40426	Agelas oroides enoyl	Strain	Agelasidae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO24632	Salvia hydrangea	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO40617	Streptomyces sp. ICBG1318	Strain	Streptomycetaceae	Bacteria	n.a.	n.a.	n.a.	Database[COCONUT]
NPO8987	Xenorhabdus nematophila	Species	Morganellaceae	Bacteria	n.a.	n.a.	n.a.	Database[COCONUT]
NPO40295	Plumarella delicatissima	Species	Primnoidae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO41008	Photorhabdus temperata Meg1	Strain	Morganellaceae	Bacteria	n.a.	n.a.	n.a.	Database[COCONUT]
NPO15440	Chamaemelum nobile	Species	Asteraceae	Eukaryota	Flower	n.a.	n.a.	Database[FooDB]
NPO15440	Chamaemelum nobile	Species	Asteraceae	Eukaryota	Plant	n.a.	n.a.	Database[FooDB]
NPO19278	Taxodium distichum	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	DOI[https://doi.org/10.1016/j.jbiosc.2016.12.008]
NPO15440	Chamaemelum nobile	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO19278	Taxodium distichum	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO24632	Salvia hydrangea	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	Database[UNPD]
NPO21618	Ircinia oros	Species	Irciniidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO8987	Xenorhabdus nematophila	Species	Morganellaceae	Bacteria	n.a.	n.a.	n.a.	Database[UNPD]
NPO15440	Chamaemelum nobile	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO19278	Taxodium distichum	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO1848	Cussonia zimmermannii	Species	Araliaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO28537	Ancistrocladus abbreviatus	Species	Ancistrocladaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO24632	Salvia hydrangea	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]

Note for Reference:
In addition to directly collecting NP source organism data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated them from below databases:
☉ UNPD: Universal Natural Products Database [PMID: 23638153].
☉ StreptomeDB: a database of streptomycetes natural products [PMID: 33051671].
☉ TM-MC: a database of medicinal materials and chemical compounds in Northeast Asian traditional medicine [PMID: 26156871].
☉ TCM@Taiwan: a Traditional Chinese Medicine database [PMID: 21253603].
☉ TCMID: a Traditional Chinese Medicine database [PMID: 29106634].
☉ TCMSP: The traditional Chinese medicine systems pharmacology database and analysis platform [PMID: 24735618].
☉ HerDing: a herb recommendation system to treat diseases using genes and chemicals [PMID: 26980517].
☉ MetaboLights: a metabolomics database [PMID: 27010336].
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].

NP Quantity Composition/Concentration

Organism ID	Organism Name	Organism Material Preparation	Organism Part	NP Quantity (Standard)	NP Quantity (Minimum)	NP Quantity (Maximum)	Quantity Unit	Reference

Note for Reference:
In addition to directly collecting NP quantitative data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated NP quantitative records for specific NP domains (e.g., NPS from foods or herbs) from domain-specific databases. These databases include:
☉ DUKE: Dr. Duke's Phytochemical and Ethnobotanical Databases.
☉ PHENOL EXPLORER: is the first comprehensive database on polyphenol content in foods [PMID: 24103452], its homepage can be accessed at here.
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].

Biological Activity

Activity Type	# Activity
IC50	502
Activity	152
Inhibition	88
AC50	71
IC70	6
EC50	85
MIC	63
IC90	2
MIC50	5
MIC90	5
GI	10
Ratio IC50	33
ED50	48
MFC	7
Ratio	1
Ratio CC50/IC50	69
MIC100	3
FC	48
Ratio EC50	5
ID50	4
CC50	94
Ratio CC50/EC50	3
Survival	1

Activity Type	# Activity
Individual protein	92
Cell line	206
Single protein	3
Organism	823
Unchecked	5
Others	161
Non-molecular	13
Protein complex	2

Molecular-level activity

Target ID	Target Type	Target Name	Target Organism	Activity Type	Activity Relation	Value	Unit	Reference
NPT1372	Individual protein	Platelet activating factor receptor	Cavia porcellus	IC50	>	200000.0	nM	PMID[7707324]
NPT1423	Individual protein	Cyclin-dependent kinase 1	Homo sapiens	IC50	>	1000000.0	nM	PMID[8691459]
NPT3060	Individual protein	Dual specificity phosphatase Cdc25A	Homo sapiens	IC50	=	25000.0	nM	PMID[8691459]
NPT208	Individual protein	Cytochrome P450 1A2	Homo sapiens	IC50	>	100000.0	nM	PMID[29407968]
NPT212	Individual protein	Cytochrome P450 2C9	Homo sapiens	IC50	>	100000.0	nM	PMID[29407968]
NPT213	Individual protein	Cytochrome P450 2C19	Homo sapiens	IC50	>	100000.0	nM	PMID[29407968]
NPT110	Individual protein	Cytochrome P450 2D6	Homo sapiens	IC50	>	100000.0	nM	PMID[29407968]
NPT109	Individual protein	Cytochrome P450 3A4	Homo sapiens	IC50	>	100000.0	nM	PMID[29407968]
NPT1433	Individual protein	Serine/threonine-protein kinase Aurora-B	Homo sapiens	IC50	>	100000.0	nM	PMID[29407968]
NPT109	Individual protein	Cytochrome P450 3A4	Homo sapiens	Inhibition	=	8.4	%	PMID[31542713]
NPT110	Individual protein	Cytochrome P450 2D6	Homo sapiens	Inhibition	=	30.8	%	PMID[31542713]
NPT213	Individual protein	Cytochrome P450 2C19	Homo sapiens	Inhibition	=	7.9	%	PMID[31542713]
NPT212	Individual protein	Cytochrome P450 2C9	Homo sapiens	Inhibition	=	-0.8	%	PMID[31542713]
NPT208	Individual protein	Cytochrome P450 1A2	Homo sapiens	Inhibition	=	-20.0	%	PMID[31542713]
NPT225	Individual protein	Beta-1 adrenergic receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT226	Individual protein	Beta-2 adrenergic receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT1464	Individual protein	Phosphodiesterase 4D	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT224	Individual protein	Alpha-2c adrenergic receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT252	Individual protein	Histamine H2 receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT1788	Individual protein	Alpha-1a adrenergic receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT263	Individual protein	Muscarinic acetylcholine receptor M2	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT272	Individual protein	Kappa opioid receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT216	Individual protein	Adenosine A1 receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT271	Individual protein	Delta opioid receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT1163	Individual protein	Glutamate (NMDA) receptor subunit zeta 1	Rattus norvegicus	AC50	>	30000.0	nM	PMID[37468498]
NPT2719	Individual protein	Voltage-gated L-type calcium channel alpha-1C subunit	Rattus norvegicus	AC50	>	30000.0	nM	PMID[37468498]
NPT267	Individual protein	Neuropeptide Y receptor type 1	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT243	Individual protein	Dopamine D2 receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT31	Individual protein	Cyclooxygenase-2	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT232	Individual protein	Cannabinoid CB1 receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT251	Individual protein	Histamine H1 receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT247	Individual protein	Endothelin receptor ET-A	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT217	Individual protein	Adenosine A2a receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT239	Individual protein	Cholecystokinin A receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT222	Individual protein	Alpha-2a adrenergic receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT299	Individual protein	Androgen Receptor	Rattus norvegicus	AC50	>	30000.0	nM	PMID[37468498]
NPT262	Individual protein	Muscarinic acetylcholine receptor M1	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT295	Individual protein	Serotonin transporter	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT290	Individual protein	Serotonin 2a (5-HT2a) receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT292	Individual protein	Serotonin 2c (5-HT2c) receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT1410	Individual protein	GABA receptor alpha-1 subunit	Rattus norvegicus	AC50	>	30000.0	nM	PMID[37468498]
NPT246	Individual protein	Dopamine transporter	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT228	Individual protein	Norepinephrine transporter	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT291	Individual protein	Serotonin 2b (5-HT2b) receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT230	Individual protein	Bradykinin B2 receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT2879	Individual protein	Equilibrative nucleoside transporter 1	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT223	Individual protein	Alpha-2b adrenergic receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT303	Individual protein	Vasopressin V1a receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT242	Individual protein	Dopamine D1 receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT264	Individual protein	Muscarinic acetylcholine receptor M3	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT1647	Individual protein	Vasopressin V2 receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT244	Individual protein	Dopamine D3 receptor	Homo sapiens	AC50	>	10000.0	nM	PMID[37468498]
NPT218	Individual protein	Adenosine A3 receptor	Homo sapiens	AC50	=	17999.9	nM	PMID[37468498]
NPT2769	Individual protein	Thromboxane A2 receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT108	Individual protein	Estrogen receptor alpha	Homo sapiens	AC50	=	29000.1	nM	PMID[37468498]
NPT1788	Individual protein	Alpha-1a adrenergic receptor	Homo sapiens	AC50	=	10000.0	nM	PMID[37468498]
NPT72	Individual protein	Solute carrier organic anion transporter family member 1B3	Homo sapiens	Inhibition	=	93.25	%	PMID[23571415]
NPT987	Individual protein	Histamine H3 receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT5301	Individual protein	Motilin receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT73	Individual protein	Solute carrier organic anion transporter family member 1B1	Homo sapiens	Inhibition	=	89.28	%	PMID[23571415]
NPT98	Individual protein	HERG	Homo sapiens	IC50	>	100000.0	nM	PMID[29407968]
NPT98	Individual protein	HERG	Homo sapiens	Inhibition	=	-16.9	%	PMID[31542713]
NPT4358	Individual protein	Type-1 angiotensin II receptor	Homo sapiens	AC50	=	15000.0	nM	PMID[37468498]
NPT692	Individual protein	Histone deacetylase 6	Homo sapiens	Inhibition	=	4.32	%	HDAC6 screening dataset using tau-based substrate in an enzymatic assay yields selective inhibitors and activators
NPT692	Individual protein	Histone deacetylase 6	Homo sapiens	Inhibition	=	6.39	%	HDAC6 screening dataset using tau-based substrate in an enzymatic assay yields selective inhibitors and activators
NPT4729	Individual protein	Cholecystokinin B receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT98	Individual protein	HERG	Homo sapiens	AC50	=	18999.8	nM	PMID[37468498]
NPT542	Individual protein	Progesterone receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT29430	Single protein	Neuronal acetylcholine receptor protein alpha-4 subunit	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT4418	Individual protein	Autotaxin	Homo sapiens	Activity	=	114.0	%	PMID[19345587]
NPT4418	Individual protein	Autotaxin	Homo sapiens	Activity	=	113.0	%	PMID[19345587]
NPT4418	Individual protein	Autotaxin	Homo sapiens	Activity	=	92.0	%	PMID[19345587]
NPT728	Individual protein	Serine/threonine-protein kinase AKT	Homo sapiens	IC50	=	9600.0	nM	PMID[23415083]
NPT5104	Individual protein	Phosphodiesterase 3A	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT5975	Individual protein	Cyclooxygenase-1	Rattus norvegicus	AC50	>	30000.0	nM	PMID[37468498]
NPT92	Individual protein	Serotonin 1a (5-HT1a) receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT28814	Single protein	Ghrelin receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT543	Individual protein	Pregnane X receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT425	Individual protein	Serotonin 3a (5-HT3a) receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT30151	Single protein	Melanocortin receptor 3	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]

In vitro activity

Target ID	Target Type	Target Name	Target Organism	Activity Type	Activity Relation	Value	Unit	Reference
NPT90	Cell line	DU-145	Homo sapiens	IC50	=	24920.0	nM	PMID[11728191]
NPT397	Cell line	NCI-H460	Homo sapiens	IC50	=	6620.0	nM	PMID[11728191]
NPT139	Cell line	HT-29	Homo sapiens	IC50	=	6150.0	nM	PMID[11728191]
NPT2829	Cell line	MES-SA/DxS	Homo sapiens	IC50	=	5350.0	nM	PMID[11728191]
NPT377	Cell line	OVCAR-3	Homo sapiens	IC50	>	30000.0	nM	PMID[8691486]
NPT116	Cell line	HL-60	Homo sapiens	IC50	=	20400.0	nM	PMID[7707324]
NPT731	Cell line	LXFL 529	Homo sapiens	IC70	=	9.574	ug ml-1	PMID[8691459]
NPT4267	Cell line	MEXF989	Homo sapiens	IC70	>	10000.0	ug ml-1	PMID[8691459]
NPT400	Cell line	MDA-MB-435	Homo sapiens	IC50	=	5000.0	nM	PMID[16279790]
NPT400	Cell line	MDA-MB-435	Homo sapiens	IC50	=	23000.0	nM	PMID[16279790]
NPT1970	Cell line	THP-1	Homo sapiens	IC50	=	28603.0	nM	PMID[17158053]
NPT1970	Cell line	THP-1	Homo sapiens	IC50	=	28600.0	nM	PMID[18220332]
NPT839	Cell line	L6	Rattus norvegicus	IC50	=	147000.0	nM	PMID[18989953]
NPT15	Cell line	Jurkat	Homo sapiens	IC50	=	10000.0	nM	PMID[19762125]
NPT404	Cell line	CCRF-CEM	Homo sapiens	IC50	=	13500.0	nM	PMID[19762125]
NPT165	Cell line	HeLa	Homo sapiens	IC50	=	41600.0	nM	PMID[19762125]
NPT82	Cell line	MDA-MB-231	Homo sapiens	IC50	=	37600.0	nM	PMID[19762125]
NPT83	Cell line	MCF7	Homo sapiens	IC50	=	39200.0	nM	PMID[19762125]
NPT81	Cell line	A549	Homo sapiens	IC50	=	44700.0	nM	PMID[19762125]
NPT1855	Cell line	HFL1	Homo sapiens	IC50	=	203400.0	nM	PMID[19818608]
NPT165	Cell line	HeLa	Homo sapiens	IC50	=	128900.0	nM	PMID[19818608]
NPT839	Cell line	L6	Rattus norvegicus	IC50	=	58400.0	nM	PMID[19781948]
NPT139	Cell line	HT-29	Homo sapiens	IC50	=	48600.0	nM	PMID[20039643]
NPT83	Cell line	MCF7	Homo sapiens	IC50	=	42300.0	nM	PMID[20039643]
NPT762	Cell line	A-431	Homo sapiens	IC50	=	53700.0	nM	PMID[20039643]
NPT521	Cell line	RBL-2H3	Rattus norvegicus	IC50	=	4600.0	nM	PMID[20153565]
NPT521	Cell line	RBL-2H3	Rattus norvegicus	Inhibition	=	87.0	%	PMID[20153565]
NPT927	Cell line	PBMC	Homo sapiens	Activity	=	29.0	%	PMID[20546981]
NPT927	Cell line	PBMC	Homo sapiens	Activity	=	35.0	%	PMID[20546981]
NPT1970	Cell line	THP-1	Homo sapiens	IC50	=	28600.0	nM	PMID[20719503]
NPT521	Cell line	RBL-2H3	Rattus norvegicus	IC50	=	4600.0	nM	PMID[21421276]
NPT1970	Cell line	THP-1	Homo sapiens	IC50	=	18500.0	nM	PMID[21571403]
NPT15	Cell line	Jurkat	Homo sapiens	IC50	=	33350.0	nM	PMID[21571403]
NPT81	Cell line	A549	Homo sapiens	IC50	=	9700.0	nM	PMID[22138309]
NPT83	Cell line	MCF7	Homo sapiens	IC50	=	11400.0	nM	PMID[22138309]
NPT1970	Cell line	THP-1	Homo sapiens	IC50	=	7000.0	nM	PMID[22939695]
NPT113	Cell line	RAW264.7	Mus musculus	IC50	=	20000.0	nM	PMID[22989363]
NPT839	Cell line	L6	Rattus norvegicus	IC50	=	143100.0	nM	PMID[23153330]
NPT83	Cell line	MCF7	Homo sapiens	IC50	=	11400.0	nM	PMID[23415083]
NPT81	Cell line	A549	Homo sapiens	IC50	=	9700.0	nM	PMID[23415083]
NPT189	Cell line	Vero	Chlorocebus aethiops	IC50	=	64960.0	nM	PMID[23727538]
NPT81	Cell line	A549	Homo sapiens	Ratio IC50	>	10.0	n.a.	PMID[23792315]
NPT737	Cell line	HUVEC	Homo sapiens	IC50	>	100000.0	nM	PMID[23792315]
NPT82	Cell line	MDA-MB-231	Homo sapiens	IC50	=	34800.0	nM	PMID[23792315]
NPT83	Cell line	MCF7	Homo sapiens	IC50	=	18900.0	nM	PMID[23792315]
NPT81	Cell line	A549	Homo sapiens	IC50	=	8600.0	nM	PMID[23792315]
NPT165	Cell line	HeLa	Homo sapiens	IC50	=	74400.0	nM	PMID[23792315]
NPT404	Cell line	CCRF-CEM	Homo sapiens	IC50	=	20700.0	nM	PMID[23792315]
NPT65	Cell line	HepG2	Homo sapiens	IC50	>	25.0	ug.mL-1	PMID[23891181]
NPT189	Cell line	Vero	Chlorocebus aethiops	IC50	>	25.0	ug.mL-1	PMID[23891181]
NPT1970	Cell line	THP-1	Homo sapiens	IC50	=	18500.0	nM	PMID[24448421]
NPT1182	Cell line	J774.A1	Mus musculus	IC50	=	25350.0	nM	PMID[24635539]
NPT1970	Cell line	THP-1	Homo sapiens	EC50	=	26860.0	nM	PMID[25462252]
NPT83	Cell line	MCF7	Homo sapiens	IC50	=	34700.0	nM	PMID[25128666]
NPT82	Cell line	MDA-MB-231	Homo sapiens	IC50	=	2075.0	nM	PMID[25128666]
NPT83	Cell line	MCF7	Homo sapiens	Activity	=	64.8	%	PMID[25128666]
NPT83	Cell line	MCF7	Homo sapiens	Activity	=	33.07	%	PMID[25128666]
NPT83	Cell line	MCF7	Homo sapiens	Activity	=	2.14	%	PMID[25128666]
NPT83	Cell line	MCF7	Homo sapiens	Activity	=	3.48	%	PMID[25128666]
NPT83	Cell line	MCF7	Homo sapiens	Activity	=	43.6	%	PMID[25128666]
NPT83	Cell line	MCF7	Homo sapiens	Activity	=	44.84	%	PMID[25128666]
NPT83	Cell line	MCF7	Homo sapiens	Activity	=	9.43	%	PMID[25128666]
NPT83	Cell line	MCF7	Homo sapiens	Activity	=	2.15	%	PMID[25128666]
NPT83	Cell line	MCF7	Homo sapiens	Activity	=	50.05	%	PMID[25128666]
NPT1970	Cell line	THP-1	Homo sapiens	IC50	=	40500.0	nM	PMID[25846065]
NPT179	Cell line	A2780	Homo sapiens	IC50	=	8870.0	nM	PMID[25698517]
NPT83	Cell line	MCF7	Homo sapiens	IC50	=	35680.0	nM	PMID[25698517]
NPT708	Cell line	HuT78	Homo sapiens	IC50	=	67240.0	nM	PMID[25698517]
NPT1970	Cell line	THP-1	Homo sapiens	IC50	=	81280.0	nM	PMID[25698517]
NPT81	Cell line	A549	Homo sapiens	IC50	=	8500.0	nM	PMID[25814031]
NPT65	Cell line	HepG2	Homo sapiens	IC50	=	26300.0	nM	PMID[25814031]
NPT762	Cell line	A-431	Homo sapiens	IC50	=	12000.0	nM	PMID[25814031]
NPT83	Cell line	MCF7	Homo sapiens	IC50	=	9200.0	nM	PMID[25814031]
NPT165	Cell line	HeLa	Homo sapiens	IC50	=	16500.0	nM	PMID[25814031]
NPT2679	Cell line	LLC-MK2	Macaca mulatta	IC50	=	122000.0	nM	PMID[25924111]
NPT839	Cell line	L6	Rattus norvegicus	IC50	=	143000.0	nM	PMID[26237241]
NPT839	Cell line	L6	Rattus norvegicus	IC50	=	137000.0	nM	PMID[28284860]
NPT1970	Cell line	THP-1	Homo sapiens	IC50	=	54080.0	nM	PMID[28359789]
NPT1182	Cell line	J774.A1	Mus musculus	IC50	>	50000.0	nM	PMID[28835791]
NPT113	Cell line	RAW264.7	Mus musculus	IC50	=	44780.0	nM	PMID[28826085]
NPT1460	Cell line	L929	Mus musculus	IC50	=	241400.0	nM	PMID[28881289]
NPT81	Cell line	A549	Homo sapiens	IC50	>	100000.0	nM	PMID[29407968]
NPT1374	Cell line	WI-38	Homo sapiens	IC50	>	100000.0	nM	PMID[29407968]
NPT401	Cell line	786-0	Homo sapiens	IC50	>	100000.0	nM	PMID[29407968]
NPT1970	Cell line	THP-1	Homo sapiens	EC50	=	19000.0	nM	PMID[29501944]
NPT1970	Cell line	THP-1	Homo sapiens	IC50	=	15850.0	nM	PMID[30100019]
NPT401	Cell line	786-0	Homo sapiens	Activity	=	3.4	%	PMID[31542713]
NPT81	Cell line	A549	Homo sapiens	Activity	=	95.8	%	PMID[31542713]
NPT1970	Cell line	THP-1	Homo sapiens	EC50	=	26250.0	nM	PMID[31702921]
NPT1970	Cell line	THP-1	Homo sapiens	IC50	=	18500.0	nM	PMID[32223141]
NPT1970	Cell line	THP-1	Homo sapiens	EC50	=	26860.0	nM	PMID[31425910]
NPT189	Cell line	Vero	Chlorocebus aethiops	IC50	=	21600.0	nM	PMID[30728107]
NPT1182	Cell line	J774.A1	Mus musculus	Activity	=	7.3	%	PMID[31761725]
NPT1182	Cell line	J774.A1	Mus musculus	Activity	=	12.4	%	PMID[31761725]
NPT839	Cell line	L6	Rattus norvegicus	IC50	=	137000.0	nM	PMID[31784198]
NPT1182	Cell line	J774.A1	Mus musculus	IC50	>	120000.0	nM	PMID[32281798]
NPT1970	Cell line	THP-1	Homo sapiens	EC50	>	50118.72	nM	PMID[32663005]
NPT1160	Cell line	BJ	Homo sapiens	IC50	>	50000.0	nM	PMID[33091607]
NPT171	Cell line	MRC5	Homo sapiens	IC50	>	50000.0	nM	PMID[33091607]
NPT1970	Cell line	THP-1	Homo sapiens	IC50	=	31500.0	nM	PMID[26791014]
NPT1970	Cell line	THP-1	Homo sapiens	IC50	=	18500.0	nM	PMID[32738977]
NPT1970	Cell line	THP-1	Homo sapiens	EC50	>	25000.0	nM	PMID[33945281]
NPT1970	Cell line	THP-1	Homo sapiens	IC50	=	18500.0	nM	PMID[32668302]
NPT1970	Cell line	THP-1	Homo sapiens	EC50	=	4670.0	nM	PMID[30234295]
NPT762	Cell line	A-431	Homo sapiens	Inhibition	=	35.4	%	PMID[36481599]
NPT65	Cell line	HepG2	Homo sapiens	EC50	>	75000.0	nM	PMID[33945281]
NPT65	Cell line	HepG2	Homo sapiens	Inhibition	=	31.3	%	PMID[36481599]
NPT83	Cell line	MCF7	Homo sapiens	Inhibition	=	69.4	%	PMID[36481599]
NPT1160	Cell line	BJ	Homo sapiens	EC50	n.a.	n.a.	n.a.	PMID[37216489]
NPT1886	Cell line	J774	Mus musculus	ID50	=	136.0	uM	PMID[19616875]
NPT1970	Cell line	THP-1	Homo sapiens	CC50	=	28600.0	nM	PMID[19926293]
NPT1182	Cell line	J774.A1	Mus musculus	CC50	=	31.31	ug.mL-1	PMID[20199824]
NPT1182	Cell line	J774.A1	Mus musculus	CC50	=	3230.0	nM	PMID[21385661]
NPT1182	Cell line	J774.A1	Mus musculus	CC50	=	94600.0	nM	PMID[22608675]
NPT65	Cell line	HepG2	Homo sapiens	CC50	=	50300.0	nM	PMID[22608675]
NPT91	Cell line	KB	Homo sapiens	CC50	=	3230.0	nM	PMID[23031588]
NPT91	Cell line	KB	Homo sapiens	CC50	=	3200.0	nM	PMID[23182089]
NPT91	Cell line	KB	Homo sapiens	CC50	=	3230.0	nM	PMID[23177254]
NPT189	Cell line	Vero	Chlorocebus aethiops	CC50	=	54700.0	nM	PMID[23582274]
NPT189	Cell line	Vero	Chlorocebus aethiops	CC50	=	52470.0	nM	PMID[23611626]
NPT189	Cell line	Vero	Chlorocebus aethiops	CC50	=	54700.0	nM	PMID[23910597]
NPT189	Cell line	Vero	Chlorocebus aethiops	CC50	=	52740.0	nM	PMID[24095747]
NPT65	Cell line	HepG2	Homo sapiens	CC50	=	50300.0	nM	PMID[24080103]
NPT1886	Cell line	J774	Mus musculus	CC50	=	135900.0	nM	PMID[24151871]
NPT189	Cell line	Vero	Chlorocebus aethiops	CC50	=	53120.0	nM	PMID[24900613]
NPT189	Cell line	Vero	Chlorocebus aethiops	CC50	=	54760.0	nM	PMID[24314395]
NPT1970	Cell line	THP-1	Homo sapiens	CC50	=	22700.0	nM	DOI[10.1039/C3MD00299C]
NPT189	Cell line	Vero	Chlorocebus aethiops	CC50	=	52500.0	nM	PMID[24635539]
NPT189	Cell line	Vero	Chlorocebus aethiops	CC50	=	52500.0	nM	PMID[24858541]
NPT189	Cell line	Vero	Chlorocebus aethiops	CC50	=	52860.0	nM	PMID[25475205]
NPT1886	Cell line	J774	Mus musculus	CC50	=	163600.0	nM	PMID[24953952]
NPT1970	Cell line	THP-1	Homo sapiens	CC50	=	18900.0	nM	PMID[25036797]
NPT65	Cell line	HepG2	Homo sapiens	CC50	=	50300.0	nM	PMID[25846065]
NPT65	Cell line	HepG2	Homo sapiens	CC50	=	50300.0	nM	PMID[25559208]
NPT91	Cell line	KB	Homo sapiens	CC50	=	54100.0	nM	PMID[26318065]
NPT189	Cell line	Vero	Chlorocebus aethiops	CC50	=	56500.0	nM	DOI[10.1039/C4MD00298A]
NPT189	Cell line	Vero	Chlorocebus aethiops	CC50	=	53100.0	nM	PMID[26840364]
NPT1886	Cell line	J774	Mus musculus	CC50	=	55700.0	nM	PMID[28059524]
NPT189	Cell line	Vero	Chlorocebus aethiops	CC50	=	50800.0	nM	PMID[28059524]
NPT189	Cell line	Vero	Chlorocebus aethiops	CC50	=	120.0	nM	PMID[28645659]
NPT1182	Cell line	J774.A1	Mus musculus	CC50	=	73700.0	nM	PMID[29126735]
NPT189	Cell line	Vero	Chlorocebus aethiops	CC50	=	99730.0	nM	PMID[29656201]
NPT1182	Cell line	J774.A1	Mus musculus	CC50	=	56000.0	nM	PMID[29793211]
NPT65	Cell line	HepG2	Homo sapiens	CC50	=	85000.0	nM	PMID[29885575]
NPT1970	Cell line	THP-1	Homo sapiens	CC50	>	40000.0	nM	PMID[29885575]
NPT1970	Cell line	THP-1	Homo sapiens	CC50	=	15000.0	nM	PMID[29407968]
NPT1045	Cell line	U2OS	Homo sapiens	CC50	=	11500.0	nM	PMID[29407968]
NPT1182	Cell line	J774.A1	Mus musculus	CC50	=	40500.0	nM	PMID[29549842]
NPT1182	Cell line	J774.A1	Mus musculus	CC50	=	12420.0	nM	PMID[30108893]
NPT65	Cell line	HepG2	Homo sapiens	CC50	=	85000.0	nM	PMID[30092366]
NPT1970	Cell line	THP-1	Homo sapiens	CC50	>	40000.0	nM	PMID[30092366]
NPT1182	Cell line	J774.A1	Mus musculus	CC50	=	55000.0	nM	PMID[31098003]
NPT189	Cell line	Vero	Chlorocebus aethiops	CC50	=	99730.0	nM	PMID[31260888]
NPT1886	Cell line	J774	Mus musculus	CC50	=	136400.0	nM	PMID[30840453]
NPT65	Cell line	HepG2	Homo sapiens	CC50	=	85000.0	nM	PMID[32292551]
NPT65	Cell line	HepG2	Homo sapiens	CC50	=	85000.0	nM	PMID[30655943]
NPT1970	Cell line	THP-1	Homo sapiens	CC50	>	40000.0	nM	PMID[30655943]
NPT839	Cell line	L6	Rattus norvegicus	CC50	=	137000.0	nM	PMID[30615444]
NPT71	Cell line	HEK293	Homo sapiens	CC50	>	10000.0	nM	DOI[10.6019/CHEMBL4296181]
NPT1182	Cell line	J774.A1	Mus musculus	CC50	=	53330.0	nM	PMID[33479698]
NPT1970	Cell line	THP-1	Homo sapiens	CC50	=	60730.0	nM	PMID[33493972]
NPT65	Cell line	HepG2	Homo sapiens	CC50	=	85000.0	nM	PMID[32652409]
NPT1970	Cell line	THP-1	Homo sapiens	CC50	=	35000.0	nM	PMID[32652409]
NPT65	Cell line	HepG2	Homo sapiens	CC50	=	85000.0	nM	PMID[32795774]
NPT171	Cell line	MRC5	Homo sapiens	CC50	n.a.	n.a.	n.a.	PMID[35533570]
NPT1886	Cell line	J774	Mus musculus	CC50	=	72350.0	nM	PMID[35814931]
NPT1182	Cell line	J774.A1	Mus musculus	CC50	=	52100.0	nM	PMID[37360388]
NPT1970	Cell line	THP-1	Homo sapiens	CC50	>	20000.0	nM	PMID[35810535]
NPT1182	Cell line	J774.A1	Mus musculus	CC50	=	53330.0	nM	PMID[36565533]
NPT1886	Cell line	J774	Mus musculus	CC50	=	135900.0	nM	PMID[33901901]
NPT65	Cell line	HepG2	Homo sapiens	CC50	>	75000.0	nM	PMID[36075146]
NPT65	Cell line	HepG2	Homo sapiens	CC50	>	75000.0	nM	PMID[36332553]
NPT113	Cell line	RAW264.7	Mus musculus	CC50	=	43010.0	nM	PMID[33148491]
NPT1970	Cell line	THP-1	Homo sapiens	CC50	=	28800.0	nM	PMID[35178179]
NPT1460	Cell line	L929	Mus musculus	CC50	=	119700.0	nM	PMID[37484568]
NPT1970	Cell line	THP-1	Homo sapiens	CC50	=	30880.0	nM	PMID[36105326]
NPT65	Cell line	HepG2	Homo sapiens	CC50	=	78620.0	nM	PMID[35814931]
NPT1886	Cell line	J774	Mus musculus	CC50	=	50000.0	nM	PMID[36508970]
NPT737	Cell line	HUVEC	Homo sapiens	CC50	=	54300.0	nM	PMID[34116159]
NPT171	Cell line	MRC5	Homo sapiens	CC50	=	36800.0	nM	PMID[33148491]
NPT171	Cell line	MRC5	Homo sapiens	CC50	>	64000.0	nM	PMID[34711050]
NPT19198	Cell line	OVXF1023 cell line	Homo sapiens	IC70	>	10000.0	ug ml-1	PMID[8691459]
NPT1605	Organism	Enterococcus	Enterococcus	MIC	=	44000.0	nM	PMID[17532639]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC	=	11000.0	nM	PMID[17532639]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC	=	5000.0	nM	PMID[17353242]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC	=	6250.0	nM	PMID[17353242]
NPT878	Organism	Streptococcus mutans	Streptococcus mutans	MIC	=	20000.0	nM	PMID[17353242]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	Activity	=	2.0	n.a.	PMID[17353242]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	Activity	=	4.0	n.a.	PMID[17353242]
NPT3651	Organism	Trichophyton tonsurans	Trichophyton tonsurans	MIC	=	0.398	ug.mL-1	PMID[17371821]
NPT3651	Organism	Trichophyton tonsurans	Trichophyton tonsurans	MIC50	=	0.25	ug.mL-1	PMID[17371821]
NPT3651	Organism	Trichophyton tonsurans	Trichophyton tonsurans	MIC90	=	1.0	ug.mL-1	PMID[17371821]
NPT1819	Organism	Microsporum canis	Arthroderma otae	MIC	=	0.555	ug.mL-1	PMID[17371821]
NPT2597	Organism	Arthroderma cajetani	Arthroderma cajetani	MIC	=	0.866	ug.mL-1	PMID[17371821]
NPT18219	Organism	Leishmania pifanoi	Leishmania pifanoi	GI	=	85.5	%	PMID[18706821]
NPT18219	Organism	Leishmania pifanoi	Leishmania pifanoi	GI	=	85.5	%	PMID[19837489]
NPT554	Organism	Candida glabrata	Candida glabrata	MFC	=	4.2	ug ml-1	PMID[23891181]
NPT554	Organism	Candida glabrata	Candida glabrata	MIC	=	3.3	ug.mL-1	PMID[23891181]
NPT3632	Organism	Leishmania panamensis	Leishmania panamensis	IC50	=	21300.0	nM	PMID[29461823]
NPT844	Organism	Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	=	0.04	ug.mL-1	PMID[31515186]
NPT22194	Organism	Naegleria gruberi	Naegleria gruberi	Inhibition	n.a.	4.0	%	DOI[10.6019/CHEMBL4513101]
NPT28438	Unchecked	Unchecked	n.a.	Activity	n.a.	n.a.	n.a.	PMID[36075146]
NPT28438	Unchecked	Unchecked	n.a.	IC50	=	45600.0	nM	PMID[36075146]
NPT30114	Cell line	Splenocyte	Mus musculus	Activity	n.a.	n.a.	n.a.	PMID[33992928]
NPT30114	Cell line	Splenocyte	Mus musculus	Activity	n.a.	n.a.	n.a.	PMID[37062170]
NPT28438	Unchecked	Unchecked	n.a.	CC50	=	190850.0	nM	PMID[34427442]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	22560.0	nM	PMID[12593656]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	23710.0	nM	PMID[12593656]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	1000.0	nM	PMID[12781196]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	3120.0	nM	PMID[15203133]
NPT19195	Cell line	CXF1103	n.a.	IC70	>	10000.0	ug ml-1	PMID[8691459]
NPT19199	Cell line	RXF 423	Homo sapiens	IC70	=	2.754	ug ml-1	PMID[8691459]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	7300.0	nM	PMID[16309903]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	0.12	ug.mL-1	PMID[17253841]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Activity	=	40.0	%	PMID[17283192]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Activity	=	44.4	%	PMID[17283192]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Activity	=	95.4	%	PMID[17283192]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Activity	=	38.0	%	PMID[17283192]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Activity	=	10.0	%	PMID[17283192]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Activity	=	75.0	%	PMID[17283192]
NPT633	Organism	Leishmania donovani	Leishmania donovani	EC50	=	10200.0	nM	PMID[17283192]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Activity	=	43.0	%	PMID[17242145]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Inhibition	=	66.0	%	PMID[17242145]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Activity	=	42.0	%	PMID[17242145]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Activity	=	19.0	%	PMID[17242145]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Activity	=	47.0	%	PMID[17242145]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Activity	=	25.0	%	PMID[17242145]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Activity	=	1.84	%	PMID[17242145]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Activity	=	3.85	%	PMID[17242145]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Activity	=	1.56	%	PMID[17242145]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Activity	=	4.8	%	PMID[17242145]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Activity	=	34.22	%	PMID[17242145]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Activity	=	22.33	%	PMID[17242145]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Activity	=	61.2	%	PMID[17242145]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Activity	=	52.0	%	PMID[17242145]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Activity	=	0.1	%	PMID[17242145]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Activity	=	0.2	%	PMID[17242145]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Activity	=	3.2	%	PMID[17242145]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Activity	=	26.3	%	PMID[17242145]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Activity	=	1.6	%	PMID[17242145]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Activity	=	5.1	%	PMID[17242145]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Activity	=	0.3	%	PMID[17242145]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Activity	=	0.4	%	PMID[17242145]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Activity	=	0.7	%	PMID[17242145]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Activity	=	1.4	%	PMID[17242145]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Activity	=	36.6	%	PMID[17242145]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Activity	=	41.0	%	PMID[17242145]
NPT20	Organism	Candida albicans	Candida albicans	MIC	=	5500.0	nM	PMID[17532639]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Inhibition	=	94.0	%	PMID[17178176]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Inhibition	=	69.0	%	PMID[17178176]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	23900.0	nM	PMID[17158053]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	8720.0	nM	PMID[17158053]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	33.9	ug.mL-1	PMID[17306422]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC90	=	107.51	ug.mL-1	PMID[17306422]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	260.0	nM	PMID[17949068]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	0.12	ug.mL-1	PMID[17765547]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	440.0	nM	PMID[17922552]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	710.0	nM	PMID[17922552]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	310.0	nM	PMID[18353643]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	23900.0	nM	PMID[18220332]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	8700.0	nM	PMID[18220332]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	6700.0	nM	PMID[18220332]
NPT4066	Organism	Streptococcus mitis	Streptococcus mitis	MIC	=	10000.0	nM	PMID[17353242]
NPT2710	Organism	Streptococcus agalactiae	Streptococcus agalactiae	MIC	=	20000.0	nM	PMID[17353242]
NPT329	Organism	Trichophyton rubrum	Trichophyton rubrum	MIC	=	0.547	ug.mL-1	PMID[17371821]
NPT329	Organism	Trichophyton rubrum	Trichophyton rubrum	MIC50	=	0.5	ug.mL-1	PMID[17371821]
NPT329	Organism	Trichophyton rubrum	Trichophyton rubrum	MIC90	=	1.0	ug.mL-1	PMID[17371821]
NPT330	Organism	Trichophyton mentagrophytes	Trichophyton mentagrophytes	MIC	=	1.133	ug.mL-1	PMID[17371821]
NPT330	Organism	Trichophyton mentagrophytes	Trichophyton mentagrophytes	MIC50	=	1.0	ug.mL-1	PMID[17371821]
NPT330	Organism	Trichophyton mentagrophytes	Trichophyton mentagrophytes	MIC90	=	2.0	ug.mL-1	PMID[17371821]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	MIC	=	0.52	ug.mL-1	PMID[17371821]
NPT5000	Organism	Trichophyton violaceum	Trichophyton violaceum	MIC	=	0.328	ug.mL-1	PMID[17371821]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	MIC	=	0.652	ug.mL-1	PMID[17371821]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	MIC50	=	0.5	ug.mL-1	PMID[17371821]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	MIC90	=	1.0	ug.mL-1	PMID[17371821]
NPT327	Organism	Microsporum gypseum	Microsporum gypseum	MIC	=	0.842	ug.mL-1	PMID[17371821]
NPT580	Organism	Trypanosoma cruzi	Trypanosoma cruzi	IC50	=	0.23	ug.mL-1	PMID[17475370]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	0.125	ug.mL-1	PMID[18683985]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	0.305	ug.mL-1	PMID[15165131]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	280.0	nM	PMID[18476684]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	260.0	nM	PMID[18989953]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Activity	=	41.0	%	PMID[19058972]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	0.305	ug.mL-1	PMID[14510589]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	0.305	ug.mL-1	PMID[15620251]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Activity	=	50.0	%	PMID[19339182]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	5.0	ug.mL-1	PMID[19339182]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	0.56	ug.mL-1	PMID[15921407]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	220.0	nM	PMID[18644723]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	1740.0	nM	PMID[18644723]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	0.2	ug.mL-1	PMID[17562801]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	700.0	nM	PMID[19091562]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	338.0	nM	PMID[17709461]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	340.0	nM	PMID[19414258]
NPT633	Organism	Leishmania donovani	Leishmania donovani	EC50	=	5700.0	nM	PMID[17908944]
NPT633	Organism	Leishmania donovani	Leishmania donovani	ED50	=	10.03	mg.kg-1	PMID[17908944]
NPT633	Organism	Leishmania donovani	Leishmania donovani	EC50	=	2040.0	nM	PMID[17908944]
NPT633	Organism	Leishmania donovani	Leishmania donovani	ED50	=	7.72	mg.kg-1	PMID[17908944]
NPT633	Organism	Leishmania donovani	Leishmania donovani	ED50	=	8.09	mg.kg-1	PMID[17908944]
NPT20	Organism	Candida albicans	Candida albicans	MFC	=	4.0	uM	PMID[19762125]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	142.0	nM	PMID[19817445]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	811.0	nM	PMID[19894726]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	430.0	nM	PMID[19894726]
NPT1208	Organism	Leishmania braziliensis	Leishmania braziliensis	IC50	=	9000.0	nM	PMID[19837489]
NPT20	Organism	Candida albicans	Candida albicans	MFC	=	4.0	uM	PMID[19818608]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	260.0	nM	PMID[19781948]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Activity	=	75.0	%	PMID[20128602]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	250.0	nM	PMID[19942439]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	23900.0	nM	PMID[19926293]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	8700.0	nM	PMID[19926293]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	2700.0	nM	PMID[19926293]
NPT633	Organism	Leishmania donovani	Leishmania donovani	EC50	=	270.0	nM	PMID[20185305]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	500.0	nM	PMID[20441198]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	0.643	ug.mL-1	PMID[20199824]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	12.11	ug.mL-1	PMID[20199824]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Inhibition	=	95.0	%	PMID[20199824]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	18000.0	nM	PMID[20546981]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	33000.0	nM	PMID[20546981]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Activity	=	287.0	mg	PMID[20546981]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Activity	=	43.0	%	PMID[20546981]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Activity	=	87.0	%	PMID[20546981]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	510.0	nM	PMID[20614907]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	6700.0	nM	PMID[20719503]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	2560.0	nM	PMID[20719503]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Inhibition	=	92.5	%	PMID[20573426]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	0.26	ug.mL-1	PMID[20855214]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	12900.0	nM	PMID[18644961]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	5600.0	nM	PMID[18644961]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	13600.0	nM	PMID[18644961]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Inhibition	=	91.0	%	PMID[20368397]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Inhibition	=	79.0	%	PMID[20368397]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Inhibition	=	88.0	%	PMID[20368397]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	24000.0	nM	PMID[20368397]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	15000.0	nM	PMID[20368397]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	2700.0	nM	PMID[20368397]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	8500.0	nM	PMID[20368397]
NPT3619	Organism	Naegleria fowleri	Naegleria fowleri	Activity	=	55.0	%	PMID[18765686]
NPT3619	Organism	Naegleria fowleri	Naegleria fowleri	Activity	=	79.3	%	PMID[18765686]
NPT3619	Organism	Naegleria fowleri	Naegleria fowleri	Activity	<	30.0	%	PMID[18765686]
NPT3619	Organism	Naegleria fowleri	Naegleria fowleri	Activity	=	20.0	%	PMID[18765686]
NPT3619	Organism	Naegleria fowleri	Naegleria fowleri	MIC100	=	25.0	ug ml-1	PMID[18765686]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	351.0	nM	PMID[20850207]
NPT633	Organism	Leishmania donovani	Leishmania donovani	FC	=	4.76	n.a.	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	FC	=	13.33	n.a.	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	FC	=	100.0	n.a.	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	FC	=	11.3	n.a.	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	ED50	=	0.85	ug ml-1	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	ED50	=	1.05	ug ml-1	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	ED50	=	1.86	ug ml-1	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	ED50	=	1.19	ug ml-1	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	ED50	=	0.51	ug ml-1	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	ED50	=	0.63	ug ml-1	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	ED50	=	1.57	ug ml-1	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	ED50	=	1.56	ug ml-1	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	ED50	=	1.99	ug ml-1	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	ED50	=	1.91	ug ml-1	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	ED50	=	1.59	ug ml-1	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	ED50	=	0.4	ug ml-1	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	ED50	=	1.9	ug ml-1	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	ED50	=	1.72	ug ml-1	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	ED50	=	1.24	ug ml-1	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	ED50	=	1.26	ug ml-1	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	ED50	=	1.07	ug ml-1	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	ED50	=	0.87	ug ml-1	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	ED50	=	2.32	ug ml-1	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	ED50	=	1.65	ug ml-1	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	ED50	=	1.32	ug ml-1	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	ED50	=	2.02	ug ml-1	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	ED50	=	1.62	ug ml-1	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	ED50	=	2.16	ug ml-1	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	ED50	=	1.94	ug ml-1	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	ED50	=	1.58	ug ml-1	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	ED50	=	0.47	ug ml-1	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	ED50	=	0.48	ug ml-1	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	ED50	=	0.53	ug ml-1	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	ED50	=	0.93	ug ml-1	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	ED50	=	0.72	ug ml-1	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	ED50	=	0.86	ug ml-1	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	ED50	=	0.91	ug ml-1	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	ED50	=	0.76	ug ml-1	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	ED50	=	1.08	ug ml-1	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	ED50	=	1.16	ug ml-1	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	ED50	>	15.0	ug ml-1	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	ED50	=	0.83	ug ml-1	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	FC	=	2.84	n.a.	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	FC	=	4.06	n.a.	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	FC	=	2.43	n.a.	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	FC	=	11.1	n.a.	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	FC	=	1.08	n.a.	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	FC	=	7.69	n.a.	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	FC	=	0.23	n.a.	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	FC	=	1.9	n.a.	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	FC	=	7.68	n.a.	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	FC	=	52.63	n.a.	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	FC	=	1.88	n.a.	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	FC	=	5.02	n.a.	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	FC	=	1.26	n.a.	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	FC	=	8.85	n.a.	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	FC	=	3.12	n.a.	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	FC	=	1.38	n.a.	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	FC	=	7.63	n.a.	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	FC	=	8.0	n.a.	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	FC	=	83.33	n.a.	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	FC	=	1.24	n.a.	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	FC	=	1.71	n.a.	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	FC	=	3.4	n.a.	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	FC	=	5.26	n.a.	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	FC	=	5.5	n.a.	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	FC	=	55.55	n.a.	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	FC	=	1.5	n.a.	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	FC	=	4.52	n.a.	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	FC	=	2.86	n.a.	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	FC	=	1.67	n.a.	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	FC	=	1.4	n.a.	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	FC	=	9.43	n.a.	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	FC	=	2.67	n.a.	PMID[19015344]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	0.27	nM	PMID[19364854]
NPT1208	Organism	Leishmania braziliensis	Leishmania braziliensis	IC50	=	10000.0	nM	PMID[19752271]
NPT1208	Organism	Leishmania braziliensis	Leishmania braziliensis	IC50	=	10300.0	nM	PMID[19752271]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	3000.0	nM	PMID[19752271]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	4500.0	nM	PMID[19752271]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	2000.0	nM	PMID[19752271]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	3400.0	nM	PMID[19752271]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	7100.0	nM	PMID[19752271]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	4000.0	nM	PMID[19752271]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	5500.0	nM	PMID[19752271]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	3200.0	nM	PMID[19752271]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	1500.0	nM	PMID[19752271]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	205.0	nM	PMID[19564359]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	Activity	=	98.0	%	PMID[21474310]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	520.0	nM	PMID[21348447]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Inhibition	=	99.9	%	PMID[21385661]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	13400.0	nM	PMID[21385661]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	386.0	nM	PMID[21456549]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	2840.0	nM	PMID[21571403]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	15000.0	nM	PMID[21571403]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	530.0	nM	PMID[21846091]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	280.0	nM	PMID[21868222]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	370.0	nM	PMID[21937228]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	440.0	nM	PMID[22023653]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	445.0	nM	PMID[22061825]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	12100.0	nM	PMID[22138309]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	0.171	ug.mL-1	PMID[22217867]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	500.0	nM	PMID[22285027]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	3700.0	nM	PMID[22472166]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	5000.0	nM	PMID[22472166]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	12070.0	nM	PMID[22608390]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	0.19	ug.mL-1	PMID[22352841]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	3100.0	nM	PMID[22608675]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	11600.0	nM	PMID[22608675]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	6800.0	nM	PMID[22608675]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	382.0	nM	PMID[22550999]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	490.0	nM	PMID[22932312]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Activity	=	96.0	%	PMID[22765899]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	12500.0	nM	PMID[23031588]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Inhibition	=	95.28	%	PMID[23031588]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	17300.0	nM	PMID[22989363]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	16000.0	nM	PMID[22989363]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	9300.0	nM	PMID[22989363]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	4300.0	nM	PMID[22989363]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	310.0	nM	PMID[23153330]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	12500.0	nM	PMID[23182089]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	0.144	ug.mL-1	PMID[23313632]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	530.0	nM	PMID[23265884]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	360.7	nM	PMID[23360309]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Inhibition	=	95.28	%	PMID[23177254]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	12500.0	nM	PMID[23177254]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	12100.0	nM	PMID[23415083]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Inhibition	=	97.0	%	PMID[23167812]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	8600.0	nM	PMID[23582274]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Inhibition	=	100.0	%	PMID[23582274]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Inhibition	=	98.1	%	PMID[23611626]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	8400.0	nM	PMID[23611626]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	1050.0	nM	PMID[23611626]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	366.0	nM	PMID[24900706]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Inhibition	=	96.0	%	PMID[23795673]
NPT1208	Organism	Leishmania braziliensis	Leishmania braziliensis	IC50	<=	50000.0	nM	PMID[23719286]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	16240.0	nM	PMID[23727538]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Ratio IC50	=	4.0	n.a.	PMID[23727538]
NPT633	Organism	Leishmania donovani	Leishmania donovani	EC50	=	1670.0	nM	PMID[23831695]
NPT633	Organism	Leishmania donovani	Leishmania donovani	EC50	=	490.0	nM	PMID[23831695]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	3200.0	nM	PMID[23876028]
NPT20	Organism	Candida albicans	Candida albicans	MIC	=	2200.0	nM	PMID[23792315]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	4260.0	nM	PMID[23851117]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Inhibition	=	98.1	%	PMID[23910597]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	12500.0	nM	PMID[23910597]
NPT633	Organism	Leishmania donovani	Leishmania donovani	ED50	=	7.72	mg.kg-1	PMID[23891181]
NPT20	Organism	Candida albicans	Candida albicans	MFC	=	2.5	ug ml-1	PMID[23891181]
NPT20	Organism	Candida albicans	Candida albicans	MIC	=	2.5	ug.mL-1	PMID[23891181]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	3200.0	nM	PMID[24106750]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	361.0	nM	PMID[23968432]
NPT633	Organism	Leishmania donovani	Leishmania donovani	GI	=	96.55	%	PMID[24095747]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	8400.0	nM	PMID[24095747]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	378.0	nM	PMID[24012457]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	6800.0	nM	PMID[24080103]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	11600.0	nM	PMID[24080103]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	3100.0	nM	PMID[24080103]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	20900.0	nM	PMID[24151871]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	23700.0	nM	PMID[24151871]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	34100.0	nM	PMID[24151871]
NPT1208	Organism	Leishmania braziliensis	Leishmania braziliensis	IC50	=	7600.0	nM	PMID[24151871]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	17600.0	nM	PMID[24151871]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	8100.0	nM	PMID[24900613]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	8100.0	nM	PMID[24314395]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	1100.0	nM	PMID[24314395]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	2840.0	nM	PMID[24448421]
NPT633	Organism	Leishmania donovani	Leishmania donovani	EC50	=	7400.0	nM	DOI[10.1039/C3MD00299C]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	700.0	nM	DOI[10.1039/C3MD00065F]
NPT633	Organism	Leishmania donovani	Leishmania donovani	EC50	=	7100.0	nM	DOI[10.1039/C3MD00299C]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	280.0	nM	DOI[10.1039/C2MD20136D]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Inhibition	=	100.0	%	PMID[24635539]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	8400.0	nM	PMID[24635539]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Inhibition	=	98.5	%	PMID[24635539]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Inhibition	=	83.2	%	PMID[24635539]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Inhibition	=	100.0	%	PMID[24858541]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	8400.0	nM	PMID[24858541]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Inhibition	=	98.5	%	PMID[24858541]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	8100.0	nM	PMID[25475205]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	3150.0	nM	PMID[25563890]
NPT633	Organism	Leishmania donovani	Leishmania donovani	EC50	=	6600.0	nM	PMID[25462252]
NPT633	Organism	Leishmania donovani	Leishmania donovani	EC50	=	880.0	nM	PMID[25462252]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	10230.0	nM	PMID[25499437]
NPT633	Organism	Leishmania donovani	Leishmania donovani	EC50	=	0.2	ug.mL-1	PMID[24978605]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	459.0	nM	PMID[25080196]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	21300.0	nM	PMID[24953952]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	28300.0	nM	PMID[24953952]
NPT1208	Organism	Leishmania braziliensis	Leishmania braziliensis	IC50	=	27100.0	nM	PMID[24953952]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	23700.0	nM	PMID[24953952]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	20900.0	nM	PMID[24953952]
NPT633	Organism	Leishmania donovani	Leishmania donovani	EC50	=	4830.0	nM	PMID[25036797]
NPT633	Organism	Leishmania donovani	Leishmania donovani	EC50	=	11100.0	nM	PMID[25036797]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	6170.0	nM	PMID[25199582]
NPT633	Organism	Leishmania donovani	Leishmania donovani	EC50	=	7850.0	nM	PMID[25238611]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	19900.0	nM	PMID[25128666]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	25780.0	nM	PMID[25128666]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	390.0	nM	PMID[25240098]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	3100.0	nM	PMID[25846065]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	6800.0	nM	PMID[25846065]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	4200.0	nM	PMID[25846065]
NPT20	Organism	Candida albicans	Candida albicans	MIC	=	2870.0	nM	PMID[25698517]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	3100.0	nM	PMID[25559208]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	6800.0	nM	PMID[25559208]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	450.0	nM	PMID[25642604]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	3700.0	nM	PMID[25629555]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	16000.0	nM	PMID[25924111]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	5750.0	nM	PMID[25987374]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Inhibition	=	93.6	%	PMID[25749014]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	310.0	nM	PMID[26237241]
NPT1208	Organism	Leishmania braziliensis	Leishmania braziliensis	IC50	=	700.0	nM	PMID[26107111]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	3400.0	nM	PMID[26107111]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	Inhibition	=	100.0	%	PMID[26107111]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	162.0	nM	PMID[26344593]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	6894.0	nM	PMID[26344593]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	12400.0	nM	DOI[10.1039/C4MD00284A]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	8200.0	nM	PMID[26318065]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	572.0	nM	DOI[10.1039/C4MD00406J]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	162.0	nM	PMID[26363868]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	1200.0	nM	DOI[10.1039/C4MD00298A]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	8100.0	nM	DOI[10.1039/C4MD00298A]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	Activity	=	97.8	%	PMID[26571076]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	Activity	=	99.6	%	PMID[26571076]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	7260.0	nM	PMID[26571076]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	16700.0	nM	PMID[26821820]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	16400.0	nM	PMID[26821820]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	730.0	nM	PMID[26774924]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	8400.0	nM	PMID[26840364]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Inhibition	=	98.1	%	PMID[26840364]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	10400.0	nM	PMID[26922226]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	Inhibition	=	81.8	%	PMID[26901446]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	Inhibition	=	92.0	%	PMID[26901446]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	Inhibition	=	84.7	%	PMID[26901446]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Inhibition	=	98.0	%	PMID[27048943]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Inhibition	=	96.0	%	PMID[27048943]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	156.0	nM	PMID[27092415]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	3700.0	nM	PMID[26905523]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	3400.0	nM	PMID[27318121]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	150.0	nM	PMID[27318121]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	47700.0	nM	PMID[27318121]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	58100.0	nM	PMID[27318121]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	16500.0	nM	PMID[27318121]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	1900.0	nM	PMID[27793448]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	1500.0	nM	PMID[27793448]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	16000.0	nM	PMID[27586460]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	17000.0	nM	PMID[27586460]
NPT633	Organism	Leishmania donovani	Leishmania donovani	GI	=	100.0	%	PMID[28059524]
NPT633	Organism	Leishmania donovani	Leishmania donovani	GI	=	99.8	%	PMID[28059524]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	9460.0	nM	PMID[28059524]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Inhibition	>	75.0	%	PMID[28059524]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Inhibition	>	61.0	%	PMID[28059524]
NPT1208	Organism	Leishmania braziliensis	Leishmania braziliensis	GI	=	67.78	%	PMID[28119201]
NPT1208	Organism	Leishmania braziliensis	Leishmania braziliensis	EC50	<=	20000.0	nM	PMID[28119201]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	EC50	=	2650.0	nM	PMID[28064141]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	300.0	nM	PMID[28284860]
NPT20	Organism	Candida albicans	Candida albicans	Inhibition	>	90.0	%	PMID[28051303]
NPT20	Organism	Candida albicans	Candida albicans	Inhibition	=	90.0	%	PMID[28051303]
NPT20	Organism	Candida albicans	Candida albicans	MIC	=	0.5	ug.mL-1	PMID[28051303]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	27070.0	nM	PMID[28359789]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	Inhibition	=	99.0	%	PMID[29461823]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	Inhibition	=	99.5	%	PMID[29461823]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	Inhibition	=	96.8	%	PMID[29461823]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	2500.0	nM	PMID[29461823]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	2050.0	nM	PMID[29461823]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	2300.0	nM	PMID[29461823]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	>	20000.0	nM	PMID[29461823]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	3800.0	nM	PMID[29461823]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	2130.0	nM	PMID[29461823]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	4600.0	nM	PMID[29461823]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	1860.0	nM	PMID[29461823]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	1110.0	nM	PMID[29461823]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	1250.0	nM	PMID[29461823]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	740.0	nM	PMID[29461823]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	15000.0	nM	PMID[29461823]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	Activity	=	66.7	%	PMID[28433512]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	12700.0	nM	PMID[28433512]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	6600.0	nM	PMID[28433512]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	4200.0	nM	PMID[28433512]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	18900.0	nM	PMID[28433512]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	13200.0	nM	PMID[28433512]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	22000.0	nM	PMID[28433512]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	Activity	=	53.22	%	PMID[28433512]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	Activity	=	12.23	%	PMID[28433512]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	Activity	=	7.15	%	PMID[28433512]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	130.0	nM	PMID[28116906]
NPT633	Organism	Leishmania donovani	Leishmania donovani	EC50	=	3300.0	nM	PMID[28463485]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	1400.0	nM	PMID[28282127]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	5200.0	nM	PMID[28282127]
NPT633	Organism	Leishmania donovani	Leishmania donovani	GI	=	60.1	%	PMID[28789893]
NPT633	Organism	Leishmania donovani	Leishmania donovani	GI	=	93.3	%	PMID[28789893]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	250.0	nM	PMID[28789893]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Inhibition	=	92.6	%	PMID[28459575]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Inhibition	=	99.5	%	PMID[28459575]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Inhibition	=	89.0	%	PMID[28459575]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	432.0	nM	PMID[28121440]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	1350.0	nM	PMID[28645659]
NPT580	Organism	Trypanosoma cruzi	Trypanosoma cruzi	IC50	=	25250.0	nM	PMID[28645659]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	3260.0	nM	PMID[28835791]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	1430.0	nM	PMID[28835791]
NPT21752	Cell line	Peritoneal macrophage cells	n.a.	EC50	=	40660.0	nM	PMID[28826085]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	10380.0	nM	PMID[28826085]
NPT633	Organism	Leishmania donovani	Leishmania donovani	EC50	=	6400.0	nM	PMID[28826085]
NPT21752	Cell line	Peritoneal macrophage cells	n.a.	Activity	=	26.01	uM	PMID[28826085]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	510.0	nM	PMID[28840725]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	7400.0	nM	PMID[28881289]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	16200.0	nM	PMID[28881289]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	432.0	nM	PMID[29043798]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	6200.0	nM	PMID[29260557]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	6500.0	nM	PMID[29126735]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	3300.0	nM	PMID[29126735]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	3100.0	nM	PMID[29126735]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	6170.0	nM	PMID[29197735]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	120.0	nM	PMID[29896963]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	1000.0	nM	PMID[29793211]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	8000.0	nM	PMID[29793211]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	800.0	nM	PMID[29885575]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	5400.0	nM	PMID[29885575]
NPT20	Organism	Candida albicans	Candida albicans	MIC	=	0.5	ug.mL-1	PMID[29294275]
NPT20	Organism	Candida albicans	Candida albicans	Inhibition	=	90.0	%	PMID[29294275]
NPT20	Organism	Candida albicans	Candida albicans	Inhibition	>	90.0	%	PMID[29294275]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	EC50	=	2510.0	nM	PMID[29407968]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	EC50	=	1290.0	nM	PMID[29407968]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	EC50	=	47600.0	nM	PMID[29501944]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	EC50	=	2000.0	nM	PMID[29501944]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	EC50	=	12600.0	nM	PMID[29549840]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	EC50	=	4800.0	nM	PMID[29549840]
NPT633	Organism	Leishmania donovani	Leishmania donovani	EC50	=	3120.0	nM	PMID[29549840]
NPT633	Organism	Leishmania donovani	Leishmania donovani	EC50	=	2800.0	nM	PMID[29549840]
NPT633	Organism	Leishmania donovani	Leishmania donovani	EC50	=	6400.0	nM	PMID[29549840]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	EC50	=	750.0	nM	PMID[30095915]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	EC50	=	440.0	nM	PMID[30095915]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	EC50	=	730.0	nM	PMID[30095915]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	EC50	=	1530.0	nM	PMID[30095915]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	EC50	=	1130.0	nM	PMID[30095915]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	21000.0	nM	PMID[29478704]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	18500.0	nM	PMID[29549842]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	2400.0	nM	PMID[29549842]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	6100.0	nM	PMID[29604541]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	3980.0	nM	PMID[30100019]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	5010.0	nM	PMID[30100019]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	7940.0	nM	PMID[30100019]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	432.0	nM	PMID[29560715]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	1050.0	nM	PMID[30108893]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	8400.0	nM	PMID[30108893]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Inhibition	=	98.1	%	PMID[30108893]
NPT3619	Organism	Naegleria fowleri	Naegleria fowleri	IC50	=	54500.0	nM	PMID[29449910]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	560.0	nM	PMID[30006174]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	800.0	nM	PMID[30092366]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	3100.0	nM	PMID[30092366]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	4300.0	nM	PMID[30092366]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	20700.0	nM	PMID[31098003]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	1700.0	nM	PMID[31098003]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	Activity	=	1000000.0	/g	PMID[31542713]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	Activity	=	244476.11	/g	PMID[31542713]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	Inhibition	=	81.2	%	PMID[31542713]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	Inhibition	=	97.33	%	PMID[31542713]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Activity	>	50.0	%	PMID[31542713]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Activity	>	75.0	%	PMID[31542713]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	EC50	=	2510.0	nM	PMID[31542713]
NPT633	Organism	Leishmania donovani	Leishmania donovani	EC50	=	9000.0	nM	PMID[31542713]
NPT580	Organism	Trypanosoma cruzi	Trypanosoma cruzi	EC50	=	12500.0	nM	PMID[31542713]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	22000.0	nM	PMID[31605866]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	4050.0	nM	PMID[31605866]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	47700.0	nM	PMID[30840453]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	150.0	nM	PMID[30840453]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	3400.0	nM	PMID[30840453]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	11800.0	nM	PMID[30638761]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	800.0	nM	PMID[31642313]
NPT633	Organism	Leishmania donovani	Leishmania donovani	EC50	=	6510.0	nM	PMID[31702921]
NPT633	Organism	Leishmania donovani	Leishmania donovani	EC50	=	910.0	nM	PMID[31702921]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	730.0	nM	PMID[31799840]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	990.0	nM	PMID[31706668]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	2840.0	nM	PMID[32223141]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	EC50	=	800.0	nM	PMID[32292551]
NPT633	Organism	Leishmania donovani	Leishmania donovani	EC50	=	440.0	nM	PMID[31425910]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	1430.0	nM	PMID[31299585]
NPT1208	Organism	Leishmania braziliensis	Leishmania braziliensis	IC50	=	7590.0	nM	PMID[31299585]
NPT1208	Organism	Leishmania braziliensis	Leishmania braziliensis	IC50	=	890.0	nM	PMID[31299585]
NPT580	Organism	Trypanosoma cruzi	Trypanosoma cruzi	IC50	=	0.36	ug.mL-1	PMID[31515186]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	0.2	ug.mL-1	PMID[31515186]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	900.0	nM	PMID[30565934]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	3100.0	nM	PMID[30655943]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	800.0	nM	PMID[30655943]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	4300.0	nM	PMID[30655943]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	EC50	=	1290.0	nM	PMID[30908048]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	1900.0	nM	PMID[30878827]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Inhibition	=	99.5	%	PMID[31124675]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Inhibition	=	97.2	%	PMID[31124675]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Inhibition	=	99.2	%	PMID[31124675]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Inhibition	=	98.3	%	PMID[31124675]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	9590.0	nM	PMID[31124675]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Activity	>	98.0	%	PMID[31124675]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Activity	=	96.32	%	PMID[31514064]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	300.0	nM	PMID[30302998]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	560.0	nM	PMID[30615444]
NPT580	Organism	Trypanosoma cruzi	Trypanosoma cruzi	IC50	=	20800.0	nM	PMID[30728107]
NPT580	Organism	Trypanosoma cruzi	Trypanosoma cruzi	IC50	=	29600.0	nM	PMID[30728107]
NPT580	Organism	Trypanosoma cruzi	Trypanosoma cruzi	IC50	=	18800.0	nM	PMID[30728107]
NPT580	Organism	Trypanosoma cruzi	Trypanosoma cruzi	IC50	=	55900.0	nM	PMID[30728107]
NPT580	Organism	Trypanosoma cruzi	Trypanosoma cruzi	IC50	=	39700.0	nM	PMID[30728107]
NPT580	Organism	Trypanosoma cruzi	Trypanosoma cruzi	IC50	=	34800.0	nM	PMID[30728107]
NPT580	Organism	Trypanosoma cruzi	Trypanosoma cruzi	IC50	=	22900.0	nM	PMID[30728107]
NPT580	Organism	Trypanosoma cruzi	Trypanosoma cruzi	IC50	=	31800.0	nM	PMID[30728107]
NPT580	Organism	Trypanosoma cruzi	Trypanosoma cruzi	IC50	=	20100.0	nM	PMID[30728107]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	6000.0	nM	PMID[31499360]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	430.0	nM	PMID[31630523]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	2650.0	nM	PMID[27411733]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	285.0	nM	PMID[30916554]
NPT20	Organism	Candida albicans	Candida albicans	MIC	>	10000.0	nM	DOI[10.6019/CHEMBL4296181]
NPT173	Organism	Klebsiella pneumoniae	Klebsiella pneumoniae	MIC	>	10000.0	nM	DOI[10.6019/CHEMBL4296181]
NPT28314	Organism	Leishmania orientalis	Leishmania orientalis	Inhibition	=	4.0	%	PMID[31761725]
NPT28314	Organism	Leishmania orientalis	Leishmania orientalis	Inhibition	=	24.9	%	PMID[31761725]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	700.0	nM	PMID[31784198]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	2400.0	nM	PMID[32073851]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	4.54	ug.mL-1	PMID[30594028]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	8.2	ug.mL-1	PMID[30594028]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	2900.0	nM	PMID[32281798]
NPT633	Organism	Leishmania donovani	Leishmania donovani	EC50	=	3981.07	nM	PMID[32663005]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Activity	>	99.0	%	PMID[32663005]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Activity	=	4.2	%	PMID[32667203]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	5300.0	nM	PMID[33479686]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	4100.0	nM	PMID[33479686]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	3600.0	nM	PMID[33479686]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	3800.0	nM	PMID[33479686]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	3400.0	nM	PMID[33479686]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	2520.0	nM	PMID[33479698]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	9250.0	nM	PMID[33479698]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Inhibition	=	97.32	%	PMID[33479698]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Inhibition	=	98.41	%	PMID[33479698]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	68100.0	nM	PMID[33091297]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	1900.0	nM	PMID[33091297]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	7470.0	nM	PMID[33385837]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	11900.0	nM	PMID[26791014]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	156.0	nM	PMID[27543881]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	4980.0	nM	PMID[33493972]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	5330.0	nM	PMID[33493972]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	2840.0	nM	PMID[32738977]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	2300.0	nM	PMID[32590115]
NPT633	Organism	Leishmania donovani	Leishmania donovani	EC50	=	3100.0	nM	PMID[32652409]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	770.0	nM	PMID[32745819]
NPT633	Organism	Leishmania donovani	Leishmania donovani	EC50	=	3100.0	nM	PMID[32795774]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	EC50	=	800.0	nM	PMID[32795774]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	390.0	nM	PMID[33843232]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	432.0	nM	PMID[36972793]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	0.26	ug.mL-1	PMID[37942619]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	EC50	=	7470.0	nM	PMID[33667845]
NPT3619	Organism	Naegleria fowleri	Naegleria fowleri	EC50	=	35700.0	nM	PMID[38229759]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	EC50	=	38200.0	nM	PMID[36508970]
NPT633	Organism	Leishmania donovani	Leishmania donovani	EC50	=	10000.0	nM	PMID[34711050]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	3400.0	nM	PMID[34531949]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	EC50	=	2000.0	nM	PMID[33945281]
NPT1208	Organism	Leishmania braziliensis	Leishmania braziliensis	IC50	=	8330.0	nM	PMID[33148491]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	7470.0	nM	PMID[33784107]
NPT633	Organism	Leishmania donovani	Leishmania donovani	EC50	=	12000.0	nM	PMID[34355566]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	9400.0	nM	PMID[32668302]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	1700.0	nM	PMID[34116159]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	Activity	n.a.	n.a.	n.a.	PMID[34427442]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	8050.0	nM	PMID[37360388]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	6500.0	nM	PMID[37484568]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	5110.0	nM	PMID[34427442]
NPT580	Organism	Trypanosoma cruzi	Trypanosoma cruzi	EC50	=	920.0	nM	PMID[30234295]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	1830.0	nM	PMID[33148491]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	Activity	=	94.0	%	PMID[35533570]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	6120.0	nM	PMID[35814931]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Inhibition	=	97.4	%	PMID[35814931]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	EC50	=	600.0	nM	PMID[36332553]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	EC50	=	600.0	nM	PMID[33945281]
NPT633	Organism	Leishmania donovani	Leishmania donovani	EC50	=	6200.0	nM	PMID[34355566]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	390.0	nM	PMID[35810535]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	12770.0	nM	PMID[33992928]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	2960.0	nM	PMID[33148491]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	47600.0	nM	PMID[33901901]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	2207.0	nM	PMID[36105326]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	Inhibition	=	98.5	%	PMID[33268145]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	Inhibition	=	94.9	%	PMID[33268145]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	9250.0	nM	PMID[36565533]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	6860.0	nM	PMID[35814931]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	0.555	ug.mL-1	PMID[34091216]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Inhibition	=	99.7	%	PMID[33992928]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Inhibition	=	98.9	%	PMID[35814931]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	1000.0	nM	PMID[35178179]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Inhibition	=	95.3	%	PMID[33992928]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	471.0	nM	PMID[33901399]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	9420.0	nM	PMID[37360388]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	EC50	=	500.0	nM	PMID[36075146]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	190.0	nM	PMID[38107179]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	EC50	=	550.0	nM	PMID[34695777]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	370.0	nM	PMID[33901901]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	150.0	nM	PMID[33901901]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	EC50	=	47600.0	nM	PMID[33945281]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	10100.0	nM	PMID[37859724]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	30700.0	nM	PMID[33901901]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	4220.0	nM	PMID[33148491]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	10500.0	nM	PMID[35434631]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	8690.0	nM	PMID[37859724]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Inhibition	=	91.2	%	PMID[33992928]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	Inhibition	=	43.3	%	PMID[36105326]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	EC50	=	10000.0	nM	PMID[34711050]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	7080.0	nM	PMID[37062170]
NPT18901	Organism	Middle East respiratory syndrome-related coronavirus	Middle East respiratory syndrome-related coronavirus	Inhibition	=	28.0	%	PMID[34081439]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	610.0	nM	PMID[34116159]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	7010.0	nM	PMID[34531949]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	Inhibition	=	99.7	%	PMID[33268145]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	Activity	=	93.1	%	PMID[35533570]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Inhibition	=	99.4	%	PMID[33992928]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	EC50	=	8300.0	nM	PMID[35144125]
NPT633	Organism	Leishmania donovani	Leishmania donovani	EC50	=	16000.0	nM	PMID[34355566]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	8020.0	nM	PMID[34427442]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	7500.0	nM	PMID[32668302]
NPT1208	Organism	Leishmania braziliensis	Leishmania braziliensis	IC50	=	10400.0	nM	PMID[32668302]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	Activity	=	99.2	%	PMID[35533570]
NPT634	Organism	Leishmania amazonensis	Leishmania amazonensis	IC50	=	15830.0	nM	PMID[37062170]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	500.0	nM	PMID[34531949]
NPT633	Organism	Leishmania donovani	Leishmania donovani	IC50	=	24200.0	nM	PMID[34171661]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	EC50	=	520.0	nM	PMID[34695777]
NPT633	Organism	Leishmania donovani	Leishmania donovani	Inhibition	>	97.0	%	PMID[33992928]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	2840.0	nM	PMID[32668302]
NPT633	Organism	Leishmania donovani	Leishmania donovani	EC50	=	900.0	nM	PMID[36324493]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	4500.0	nM	PMID[34171661]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	EC50	=	8300.0	nM	PMID[35533570]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	EC50	=	700.0	nM	PMID[36075146]
NPT1021	Organism	Leishmania infantum	Leishmania infantum	IC50	=	9810.0	nM	PMID[34531949]
NPT1208	Organism	Leishmania braziliensis	Leishmania braziliensis	ID50	=	9.0	uM	PMID[18706821]
NPT1208	Organism	Leishmania braziliensis	Leishmania braziliensis	ID50	=	9.0	mM	PMID[19616875]
NPT1208	Organism	Leishmania braziliensis	Leishmania braziliensis	ID50	=	9.0	uM	PMID[21506600]
NPT21752	Cell line	Peritoneal macrophage cells	n.a.	CC50	=	20300.0	nM	PMID[31098003]
NPT21752	Cell line	Peritoneal macrophage cells	n.a.	CC50	=	131900.0	nM	PMID[31605866]
NPT85	Organism	Filobasidiella neoformans	Cryptococcus neoformans	MIC	=	2750.0	nM	PMID[17532639]
NPT16	Organism	Staphylococcus aureus	Staphylococcus aureus	MIC	=	22000.0	nM	PMID[17532639]
NPT16	Organism	Staphylococcus aureus	Staphylococcus aureus	MIC	=	44000.0	nM	PMID[17532639]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	>	350000.0	nM	PMID[17532639]
NPT18	Organism	Pseudomonas aeruginosa	Pseudomonas aeruginosa	MIC	>	600000.0	nM	PMID[17532639]
NPT4401	Organism	Streptococcus oralis	Streptococcus oralis	MIC	=	10000.0	nM	PMID[17353242]
NPT175	Organism	Enterococcus faecalis	Enterococcus faecalis	MIC	=	20000.0	nM	PMID[17353242]
NPT328	Organism	Epidermophyton floccosum	Epidermophyton floccosum	MIC	=	0.548	ug.mL-1	PMID[17371821]
NPT3631	Organism	Leishmania guyanensis	Leishmania guyanensis	IC50	=	7500.0	nM	PMID[19752271]
NPT3631	Organism	Leishmania guyanensis	Leishmania guyanensis	IC50	=	10000.0	nM	PMID[19752271]
NPT3631	Organism	Leishmania guyanensis	Leishmania guyanensis	IC50	=	9500.0	nM	PMID[19752271]
NPT3631	Organism	Leishmania guyanensis	Leishmania guyanensis	IC50	=	5000.0	nM	PMID[19752271]
NPT19200	Organism	Acanthamoeba lugdunensis	Acanthamoeba lugdunensis	MIC	=	250000.0	nM	PMID[23792315]
NPT85	Organism	Filobasidiella neoformans	Cryptococcus neoformans	MFC	=	2.1	ug ml-1	PMID[23891181]
NPT87	Organism	Aspergillus fumigatus	Aspergillus fumigatus	MFC	=	9.2	ug ml-1	PMID[23891181]
NPT187	Organism	Issatchenkia orientalis	Pichia kudriavzevii	MFC	=	3.3	ug ml-1	PMID[23891181]
NPT85	Organism	Filobasidiella neoformans	Cryptococcus neoformans	MIC	=	2.1	ug.mL-1	PMID[23891181]
NPT87	Organism	Aspergillus fumigatus	Aspergillus fumigatus	MIC	=	2.9	ug.mL-1	PMID[23891181]
NPT187	Organism	Issatchenkia orientalis	Pichia kudriavzevii	MIC	=	2.5	ug.mL-1	PMID[23891181]
NPT3631	Organism	Leishmania guyanensis	Leishmania guyanensis	IC50	=	44600.0	nM	PMID[24151871]
NPT3631	Organism	Leishmania guyanensis	Leishmania guyanensis	IC50	=	53600.0	nM	PMID[24953952]
NPT16	Organism	Staphylococcus aureus	Staphylococcus aureus	MIC	=	11500.0	nM	PMID[25698517]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	>	1000000.0	nM	PMID[25698517]
NPT3631	Organism	Leishmania guyanensis	Leishmania guyanensis	IC50	=	18200.0	nM	PMID[27318121]
NPT2645	Organism	Giardia intestinalis	Giardia intestinalis	IC50	=	20000.0	nM	PMID[28645659]
NPT1018	Organism	Trypanosoma brucei	Trypanosoma brucei	EC50	=	34000.0	nM	PMID[31542713]
NPT3631	Organism	Leishmania guyanensis	Leishmania guyanensis	IC50	=	18200.0	nM	PMID[30840453]
NPT24	Organism	Human immunodeficiency virus 1	Human immunodeficiency virus 1	EC50	=	10.0	nM	PMID[31499360]
NPT85	Organism	Filobasidiella neoformans	Cryptococcus neoformans	MIC	>	10000.0	nM	DOI[10.6019/CHEMBL4296181]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	>	10000.0	nM	DOI[10.6019/CHEMBL4296181]
NPT18	Organism	Pseudomonas aeruginosa	Pseudomonas aeruginosa	MIC	>	10000.0	nM	DOI[10.6019/CHEMBL4296181]
NPT2922	Organism	Staphylococcus aureus subsp. aureus	Staphylococcus aureus subsp. aureus	MIC	>	10000.0	nM	DOI[10.6019/CHEMBL4296181]
NPT28313	Organism	Leishmania martiniquensis	Leishmania martiniquensis	IC50	=	15790.0	nM	PMID[31761725]
NPT1018	Organism	Trypanosoma brucei	Trypanosoma brucei	Inhibition	n.a.	n.a.	%	PMID[35178179]
NPT29108	Cell line	Peritoneal macrophage	Mus musculus	CC50	=	33000.0	nM	PMID[34711050]
NPT29108	Cell line	Peritoneal macrophage	Mus musculus	CC50	=	169490.0	nM	PMID[34427442]
NPT30043	Cell line	Vero	Chlorocebus sabaeus	CC50	=	99700.0	nM	PMID[36493614]
NPT29108	Cell line	Peritoneal macrophage	Mus musculus	CC50	=	96500.0	nM	PMID[34531949]
NPT20763	Cell line	J774.1	Mus musculus	CC50	=	89210.0	nM	PMID[37859724]
NPT30043	Cell line	Vero	Chlorocebus sabaeus	CC50	=	51800.0	nM	PMID[36565533]
NPT29108	Cell line	Peritoneal macrophage	Mus musculus	CC50	n.a.	n.a.	n.a.	PMID[35533570]
NPT30043	Cell line	Vero	Chlorocebus sabaeus	CC50	=	99730.0	nM	PMID[37031526]
NPT19196	Cell line	LXFS538	n.a.	IC70	>	10000.0	ug ml-1	PMID[8691459]
NPT2	Others	Unspecified	n.a.	Inhibition	=	5.0	%	PMID[17283192]
NPT27	Others	Unspecified	n.a.	Activity	=	95.0	%	PMID[17532639]
NPT27	Others	Unspecified	n.a.	Activity	=	100.0	%	PMID[17532639]
NPT27	Others	Unspecified	n.a.	Activity	=	25.0	%	PMID[17532639]
NPT27	Others	Unspecified	n.a.	Activity	=	5.0	%	PMID[17532639]
NPT27	Others	Unspecified	n.a.	Activity	=	0.0	%	PMID[17532639]
NPT27	Others	Unspecified	n.a.	Activity	=	96.1	%	PMID[18220332]
NPT27	Others	Unspecified	n.a.	Activity	=	100.0	%	PMID[18220332]
NPT3627	Organism	Microsporum	Microsporum	MIC	=	0.75	ug.mL-1	PMID[17371821]
NPT3627	Organism	Microsporum	Microsporum	MIC50	=	1.0	ug.mL-1	PMID[17371821]
NPT3627	Organism	Microsporum	Microsporum	MIC90	=	1.0	ug.mL-1	PMID[17371821]
NPT2	Others	Unspecified	n.a.	Ratio IC50	=	565.0	n.a.	PMID[18989953]
NPT27	Others	Unspecified	n.a.	EC50	=	30000.0	nM	PMID[19762125]
NPT2	Others	Unspecified	n.a.	Ratio	=	15.1	n.a.	PMID[19616875]
NPT27	Others	Unspecified	n.a.	Activity	=	96.1	%	PMID[19926293]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	2.58	n.a.	PMID[20199824]
NPT27	Others	Unspecified	n.a.	Activity	=	25.0	%	PMID[19995922]
NPT27	Others	Unspecified	n.a.	Activity	=	50.0	%	PMID[19995922]
NPT27	Others	Unspecified	n.a.	Activity	=	3.91	%	PMID[19995922]
NPT27	Others	Unspecified	n.a.	Activity	=	11.41	%	PMID[19995922]
NPT27	Others	Unspecified	n.a.	Activity	=	20.7	%	PMID[19995922]
NPT27	Others	Unspecified	n.a.	Activity	=	83.98	%	PMID[19995922]
NPT27	Others	Unspecified	n.a.	Activity	=	5.83	%	PMID[19995922]
NPT27	Others	Unspecified	n.a.	Activity	=	15.89	%	PMID[19995922]
NPT27	Others	Unspecified	n.a.	Activity	=	19.91	%	PMID[19995922]
NPT27	Others	Unspecified	n.a.	Activity	=	58.38	%	PMID[19995922]
NPT27	Others	Unspecified	n.a.	Activity	=	6.6	%	PMID[19995922]
NPT27	Others	Unspecified	n.a.	Activity	=	18.57	%	PMID[19995922]
NPT27	Others	Unspecified	n.a.	Activity	=	23.15	%	PMID[19995922]
NPT27	Others	Unspecified	n.a.	Activity	=	51.67	%	PMID[19995922]
NPT27	Others	Unspecified	n.a.	Activity	=	5.16	%	PMID[19995922]
NPT27	Others	Unspecified	n.a.	Activity	=	35.67	%	PMID[19995922]
NPT27	Others	Unspecified	n.a.	Activity	=	36.02	%	PMID[19995922]
NPT27	Others	Unspecified	n.a.	Activity	=	6.2	%	PMID[19995922]
NPT27	Others	Unspecified	n.a.	Activity	=	43.18	%	PMID[19995922]
NPT27	Others	Unspecified	n.a.	Activity	=	22.72	%	PMID[19995922]
NPT27	Others	Unspecified	n.a.	Activity	=	28.9	%	PMID[19995922]
NPT27	Others	Unspecified	n.a.	Activity	=	6.56	%	PMID[19995922]
NPT27	Others	Unspecified	n.a.	Activity	=	54.56	%	PMID[19995922]
NPT27	Others	Unspecified	n.a.	Activity	=	21.16	%	PMID[19995922]
NPT27	Others	Unspecified	n.a.	Activity	=	17.73	%	PMID[19995922]
NPT2	Others	Unspecified	n.a.	Ratio IC50	=	8.7	n.a.	PMID[20719503]
NPT2	Others	Unspecified	n.a.	Ratio IC50	=	11.2	n.a.	PMID[20719503]
NPT841	Organism	Leishmania major	Leishmania major	IC50	=	25000.0	nM	PMID[20368397]
NPT841	Organism	Leishmania major	Leishmania major	EC50	=	17690.0	nM	PMID[21199921]
NPT841	Organism	Leishmania major	Leishmania major	EC50	=	25690.0	nM	PMID[21199921]
NPT841	Organism	Leishmania major	Leishmania major	Ratio EC50	=	1.5	n.a.	PMID[21199921]
NPT27	Others	Unspecified	n.a.	Ratio IC50	=	17.0	n.a.	PMID[21571403]
NPT27	Others	Unspecified	n.a.	Ratio IC50	=	7.0	n.a.	PMID[21571403]
NPT2	Others	Unspecified	n.a.	Ratio IC50	=	264.6	n.a.	PMID[21937228]
NPT2	Others	Unspecified	n.a.	Inhibition	=	56.31	%	PMID[22138309]
NPT2	Others	Unspecified	n.a.	IC50	=	9600.0	nM	PMID[22138309]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	30.5	n.a.	PMID[22608675]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	16.2	n.a.	PMID[22608675]
NPT3697	Organism	Leishmania tropica	Leishmania tropica	IC50	=	10900.0	nM	PMID[22939695]
NPT3697	Organism	Leishmania tropica	Leishmania tropica	Ratio IC50	=	22.0	n.a.	PMID[22939695]
NPT3697	Organism	Leishmania tropica	Leishmania tropica	IC50	=	239500.0	nM	PMID[22939695]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	0.26	n.a.	PMID[23031588]
NPT27	Others	Unspecified	n.a.	IC50	=	75300.0	nM	PMID[22989363]
NPT27	Others	Unspecified	n.a.	Ratio IC50	=	17.5	n.a.	PMID[22989363]
NPT27	Others	Unspecified	n.a.	Ratio IC50	=	8.1	n.a.	PMID[22989363]
NPT27	Others	Unspecified	n.a.	Ratio IC50	=	4.7	n.a.	PMID[22989363]
NPT27	Others	Unspecified	n.a.	Ratio IC50	=	4.4	n.a.	PMID[22989363]
NPT2	Others	Unspecified	n.a.	Ratio IC50	=	461.6	n.a.	PMID[23153330]
NPT3692	Organism	Leishmania aethiopica	Leishmania aethiopica	IC50	=	0.121	ug.mL-1	DOI[10.1007/s00044-013-0467-x]
NPT3692	Organism	Leishmania aethiopica	Leishmania aethiopica	IC50	=	0.136	ug.mL-1	DOI[10.1007/s00044-013-0467-x]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	0.25	n.a.	PMID[23182089]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	0.26	n.a.	PMID[23177254]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	6.0	n.a.	PMID[23582274]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	1.48	n.a.	PMID[23611626]
NPT27	Others	Unspecified	n.a.	IC50	>=	200000.0	nM	PMID[23719286]
NPT2	Others	Unspecified	n.a.	MIC	=	125000.0	nM	PMID[23792315]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	4.0	n.a.	PMID[23910597]
NPT27	Others	Unspecified	n.a.	IC50	=	2.7	ug.mL-1	PMID[23891181]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	28.9	n.a.	PMID[24106750]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	6.27	n.a.	PMID[24095747]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	16.2	n.a.	PMID[24080103]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	30.5	n.a.	PMID[24080103]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	6.56	n.a.	PMID[24900613]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	7.0	n.a.	PMID[24314395]
NPT2	Others	Unspecified	n.a.	Ratio IC50	=	7.0	n.a.	PMID[24448421]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	52.5	n.a.	PMID[24635539]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	6.2	n.a.	PMID[24858541]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	6.52	n.a.	PMID[25475205]
NPT841	Organism	Leishmania major	Leishmania major	EC50	=	16650.0	nM	PMID[25462252]
NPT841	Organism	Leishmania major	Leishmania major	EC50	=	10610.0	nM	PMID[25462252]
NPT2	Others	Unspecified	n.a.	Ratio EC50	=	2.5	n.a.	PMID[25462252]
NPT2	Others	Unspecified	n.a.	Ratio EC50	=	30.5	n.a.	PMID[25462252]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	7.7	n.a.	PMID[24953952]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	5.8	n.a.	PMID[24953952]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	6.0	n.a.	PMID[24953952]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	3.1	n.a.	PMID[24953952]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	5.7	n.a.	PMID[24953952]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	6.5	n.a.	PMID[24953952]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	16.2	n.a.	PMID[25846065]
NPT27	Others	Unspecified	n.a.	IC50	=	90400.0	nM	PMID[25846065]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	16.2	n.a.	PMID[25559208]
NPT3692	Organism	Leishmania aethiopica	Leishmania aethiopica	IC50	=	3.192	ug.mL-1	PMID[25768697]
NPT3692	Organism	Leishmania aethiopica	Leishmania aethiopica	IC50	=	0.3	ug.mL-1	PMID[25768697]
NPT2	Others	Unspecified	n.a.	Ratio IC50	=	461.6	n.a.	PMID[26237241]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	4.1	n.a.	DOI[10.1039/C4MD00284A]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	17.0	n.a.	PMID[26318065]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	7.0	n.a.	DOI[10.1039/C4MD00298A]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	3.26	n.a.	PMID[26571076]
NPT841	Organism	Leishmania major	Leishmania major	IC50	=	36000.0	nM	PMID[26708110]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	14.5	n.a.	PMID[26821820]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	14.7	n.a.	PMID[26821820]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	6.0	n.a.	PMID[26840364]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	40.1	n.a.	PMID[27318121]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	909.0	n.a.	PMID[27318121]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	2.9	n.a.	PMID[27318121]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	7.5	n.a.	PMID[27318121]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	2.3	n.a.	PMID[27318121]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	8.2	n.a.	PMID[27318121]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	7.0	n.a.	PMID[27586460]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	5.8	n.a.	PMID[28059524]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	5.3	n.a.	PMID[28059524]
NPT3692	Organism	Leishmania aethiopica	Leishmania aethiopica	IC50	=	7832.0	nM	PMID[28087274]
NPT2	Others	Unspecified	n.a.	Ratio IC50	=	1.99	n.a.	PMID[28359789]
NPT3692	Organism	Leishmania aethiopica	Leishmania aethiopica	IC50	=	36100.0	nM	PMID[29461823]
NPT841	Organism	Leishmania major	Leishmania major	IC50	=	22300.0	nM	PMID[29461823]
NPT842	Organism	Leishmania mexicana	Leishmania mexicana	IC50	=	6550.0	nM	PMID[29461823]
NPT3697	Organism	Leishmania tropica	Leishmania tropica	IC50	=	8220.0	nM	PMID[29461823]
NPT841	Organism	Leishmania major	Leishmania major	IC50	=	6070.0	nM	PMID[29323491]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	11.3	n.a.	PMID[28433512]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	21.7	n.a.	PMID[28433512]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	34.2	n.a.	PMID[28433512]
NPT1019	Organism	Trichomonas vaginalis	Trichomonas vaginalis	IC50	=	20000.0	nM	PMID[28645659]
NPT842	Organism	Leishmania mexicana	Leishmania mexicana	IC50	=	2030.0	nM	PMID[28645659]
NPT27	Others	Unspecified	n.a.	Ratio IC50	=	4.3	n.a.	PMID[28826085]
NPT27	Others	Unspecified	n.a.	Ratio EC50	=	6.34	n.a.	PMID[28826085]
NPT2	Others	Unspecified	n.a.	Ratio IC50	=	32.6	n.a.	PMID[28881289]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	23.8	n.a.	PMID[29126735]
NPT1019	Organism	Trichomonas vaginalis	Trichomonas vaginalis	MIC	=	145000.0	nM	PMID[29175675]
NPT1019	Organism	Trichomonas vaginalis	Trichomonas vaginalis	IC50	=	14500.0	nM	PMID[29175675]
NPT1019	Organism	Trichomonas vaginalis	Trichomonas vaginalis	IC50	=	20000.0	nM	PMID[29175675]
NPT2	Others	Unspecified	n.a.	IC50	>	64000.0	nM	PMID[29197735]
NPT841	Organism	Leishmania major	Leishmania major	IC50	=	7807.4	nM	PMID[29656201]
NPT841	Organism	Leishmania major	Leishmania major	IC50	=	8090.0	nM	PMID[29656201]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	12.77	n.a.	PMID[29656201]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	6.72	n.a.	PMID[29793211]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	2.2	n.a.	PMID[29549842]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	16.9	n.a.	PMID[29549842]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	1.48	n.a.	PMID[30108893]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	106.3	n.a.	PMID[30092366]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	27.4	n.a.	PMID[30092366]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	19.8	n.a.	PMID[30092366]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	3.0	n.a.	PMID[31098003]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	12.0	n.a.	PMID[31098003]
NPT841	Organism	Leishmania major	Leishmania major	IC50	=	7600.0	nM	PMID[31260888]
NPT841	Organism	Leishmania major	Leishmania major	IC50	=	7300.0	nM	PMID[31260888]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	13.1	n.a.	PMID[31260888]
NPT3692	Organism	Leishmania aethiopica	Leishmania aethiopica	IC50	=	0.3	ug.mL-1	PMID[30342363]
NPT27	Others	Unspecified	n.a.	Activity	=	5.996	g	PMID[31542713]
NPT27	Others	Unspecified	n.a.	Activity	=	0.191	g	PMID[31542713]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	32.56	n.a.	PMID[31605866]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	2.9	n.a.	PMID[30840453]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	7.5	n.a.	PMID[30840453]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	909.0	n.a.	PMID[30840453]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	40.1	n.a.	PMID[30840453]
NPT2	Others	Unspecified	n.a.	Ratio EC50	=	28.8	n.a.	PMID[31702921]
NPT2	Others	Unspecified	n.a.	Ratio IC50	=	6.51	n.a.	PMID[32223141]
NPT3697	Organism	Leishmania tropica	Leishmania tropica	IC50	=	10450.0	nM	PMID[31299585]
NPT3697	Organism	Leishmania tropica	Leishmania tropica	IC50	=	1150.0	nM	PMID[31299585]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	27.4	n.a.	PMID[30655943]
NPT21772	Protein complex	GroEL/GroES	Escherichia coli	Inhibition	=	65.0	%	PMID[30852084]
NPT21772	Protein complex	GroEL/GroES	Escherichia coli	Inhibition	=	79.0	%	PMID[30852084]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	5.8	n.a.	PMID[31124675]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	5.3	n.a.	PMID[31124675]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	5.8	n.a.	PMID[31499363]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	5.3	n.a.	PMID[31499363]
NPT2	Others	Unspecified	n.a.	Ratio IC50	=	244.6	n.a.	PMID[30615444]
NPT2	Others	Unspecified	n.a.	Ratio IC50	=	1.0	n.a.	PMID[30728107]
NPT2	Others	Unspecified	n.a.	Ratio IC50	=	0.7	n.a.	PMID[30728107]
NPT2	Others	Unspecified	n.a.	Ratio IC50	=	1.2	n.a.	PMID[30728107]
NPT2	Others	Unspecified	n.a.	Ratio IC50	=	0.4	n.a.	PMID[30728107]
NPT2	Others	Unspecified	n.a.	Ratio IC50	=	0.5	n.a.	PMID[30728107]
NPT2	Others	Unspecified	n.a.	Ratio IC50	=	0.6	n.a.	PMID[30728107]
NPT2	Others	Unspecified	n.a.	Ratio IC50	=	0.9	n.a.	PMID[30728107]
NPT2	Others	Unspecified	n.a.	Ratio IC50	=	1.1	n.a.	PMID[30728107]
NPT747	Organism	Acinetobacter baumannii	Acinetobacter baumannii	MIC	>	10000.0	nM	DOI[10.6019/CHEMBL4296181]
NPT841	Organism	Leishmania major	Leishmania major	IC50	=	8180.0	nM	PMID[33091607]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	5.76	n.a.	PMID[33479698]
NPT2	Others	Unspecified	n.a.	Ratio IC50	=	2.64	n.a.	PMID[26791014]
NPT2	Others	Unspecified	n.a.	Ratio CC50/IC50	=	11.39	n.a.	PMID[33493972]
NPT2	Others	Unspecified	n.a.	Ratio IC50	=	6.51	n.a.	PMID[32738977]
NPT842	Organism	Leishmania mexicana	Leishmania mexicana	EC50	=	2800.0	nM	PMID[37216489]
NPT841	Organism	Leishmania major	Leishmania major	IC50	=	8080.0	nM	PMID[36493614]
NPT841	Organism	Leishmania major	Leishmania major	IC50	=	7897.0	nM	PMID[36493614]
NPT841	Organism	Leishmania major	Leishmania major	IC50	=	7890.0	nM	PMID[37031526]
NPT841	Organism	Leishmania major	Leishmania major	IC50	=	3.192	ug.mL-1	PMID[32771798]
NPT28702	Cell line	Macrophage	Homo sapiens	IC50	=	36000.0	nM	PMID[35434631]
NPT841	Organism	Leishmania major	Leishmania major	Ratio IC50	=	1.0	n.a.	PMID[37031526]
NPT841	Organism	Leishmania major	Leishmania major	IC50	=	8060.0	nM	PMID[37031526]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	IC90	n.a.	n.a.	n.a.	PMID[36105326]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	IC50	n.a.	n.a.	n.a.	PMID[36105326]
NPT841	Organism	Leishmania major	Leishmania major	IC50	=	1440.0	nM	PMID[33148491]
NPT27	Others	Unspecified	n.a.	CC50	=	12420.0	nM	PMID[23611626]
NPT27	Others	Unspecified	n.a.	CC50	=	15800.0	nM	PMID[23851117]
NPT27	Others	Unspecified	n.a.	CC50	=	94600.0	nM	PMID[24080103]
NPT2	Others	Unspecified	n.a.	Ratio CC50/EC50	=	3.19	n.a.	DOI[10.1039/C3MD00299C]
NPT27	Others	Unspecified	n.a.	CC50	=	24700.0	nM	PMID[26571076]
NPT27	Others	Unspecified	n.a.	CC50	=	33100.0	nM	PMID[26571076]
NPT27	Others	Unspecified	n.a.	CC50	=	241400.0	nM	PMID[26821820]
NPT27	Others	Unspecified	n.a.	CC50	=	14300.0	nM	PMID[26840364]
NPT2	Others	Unspecified	n.a.	CC50	=	143500.0	nM	PMID[28433512]
NPT2	Others	Unspecified	n.a.	Ratio CC50/EC50	=	27.4	n.a.	PMID[32795774]
NPT2	Others	Unspecified	n.a.	Ratio CC50/EC50	=	106.3	n.a.	PMID[32795774]

In vivo activity

Target ID	Target Type	Target Name	Target Organism	Activity Type	Activity Relation	Value	Unit	Reference
NPT113	Cell line	RAW264.7	Mus musculus	Survival	=	85.0	%	PMID[22472166]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	29.6	mg/dl	PMID[18765686]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	34.6	mg/dl	PMID[18765686]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	82.4	mg/dl	PMID[18765686]
NPT32	Organism	Mus musculus	Mus musculus	CC50	=	136400.0	nM	PMID[27318121]
NPT32	Organism	Mus musculus	Mus musculus	CC50	>	100000.0	nM	PMID[27793448]
NPT32	Organism	Mus musculus	Mus musculus	CC50	=	122000.0	nM	PMID[27586460]
NPT32	Organism	Mus musculus	Mus musculus	FC	=	9.1	n.a.	PMID[28059524]
NPT32	Organism	Mus musculus	Mus musculus	FC	=	6.5	n.a.	PMID[28059524]
NPT32	Organism	Mus musculus	Mus musculus	FC	=	12.9	n.a.	PMID[28059524]
NPT32	Organism	Mus musculus	Mus musculus	FC	=	8.1	n.a.	PMID[28059524]
NPT32	Organism	Mus musculus	Mus musculus	FC	=	5.3	n.a.	PMID[28059524]
NPT32	Organism	Mus musculus	Mus musculus	FC	=	9.5	n.a.	PMID[28059524]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	87.5	%	PMID[28059524]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	88.7	%	PMID[28059524]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	94.6	%	PMID[28059524]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	92.9	%	PMID[28059524]
NPT32	Organism	Mus musculus	Mus musculus	FC	=	6.4	n.a.	PMID[28059524]
NPT32	Organism	Mus musculus	Mus musculus	FC	=	3.4	n.a.	PMID[28059524]
NPT32	Organism	Mus musculus	Mus musculus	FC	=	7.4	n.a.	PMID[28059524]
NPT32	Organism	Mus musculus	Mus musculus	FC	=	4.3	n.a.	PMID[28059524]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	0.66	mg/dl	PMID[30095915]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	271.1	U/L	PMID[30095915]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	61.14	U/L	PMID[30095915]
NPT605	Organism	Homo sapiens	Homo sapiens	IC50	=	12500.0	nM	PMID[15203133]
NPT605	Organism	Homo sapiens	Homo sapiens	Activity	=	7.5	ng/ml	PMID[18519729]
NPT605	Organism	Homo sapiens	Homo sapiens	Activity	=	30800.0	ng/ml	PMID[18519729]

Experimental ADME

Experiment Model	Experiment Tissue	ADME Type	ADME Relation	ADME Value	ADME Unit	Reference
Homo sapiens	Liver	CLH	n.a.	n.a.	n.a.	PMID[34711050]
Mesocricetus auratus	Liver	CLH	n.a.	n.a.	n.a.	PMID[34711050]

Experimental Toxicity

Quantitative toxicity

Experiment Model	Experiment Organism	Toxicity Type	Toxicity Relation	Toxicity Value	Toxicity Unit	Reference
-	Leishmania infantum	LC50	=	2000.0	nM	PMID[29017116]
-	Leishmania infantum	LC50	=	47600.0	nM	PMID[29017116]
-	Leishmania infantum	LC50	=	47600.0	nM	PMID[28431354]
-	Leishmania infantum	LC50	=	2000.0	nM	PMID[28431354]
-	Leishmania infantum	LD50	=	47.0	uM	PMID[18644968]
-	Leishmania donovani	LC50	=	12500.0	nM	PMID[20128602]
-	Leishmania donovani	LD50	=	6.5	uM	PMID[18990566]
-	Leishmania donovani	LD50	>	60.0	uM	PMID[17973359]
-	Leishmania donovani	LD50	=	12.5	uM	PMID[17973359]
-	Leishmania donovani	LD50	>	50.0	uM	PMID[16870434]
-	Leishmania donovani	LD50	=	5.3	uM	PMID[16870434]
Leishmania mexicana	Leishmania mexicana	LD50	>	50.0	uM	PMID[16870434]
Leishmania mexicana	Leishmania mexicana	LD50	=	5.0	uM	PMID[16870434]
-	Leishmania pifanoi	LC50	=	26300.0	nM	PMID[20128602]
-	Leishmania pifanoi	LD50	=	26.3	uM	PMID[17973359]

Common Abbreviations:
LC: Lethal Concentration; LD: Lethal Dose; LT:Lethal Time; NOAEL: No-observed-adverse-effect Level; BMDL: Benchmark Dose Lower Confidence Limit; BMD: Benchmark Dose; BMC:Benchmark Concentration; LOAEL: Lowest Observed Adverse Effect Level; RfD:Reference Dose; RfC:Reference Concentration; MRL: Minimal Risk Level; MEG: Maximum Exposure Guideline; PAC: Protective Action Criteria

Categorical toxicity labels

Hepatotoxicity	Carcinogenicity	Mutagenicity	Cardiotoxicity	Respiratory Toxicity	Eye Irritation	Endocrine Disruption

Note for Reference:
In addition to directly collecting NP quantitative data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated NP toxicity records from domain-specific databases. These databases include:
☉ ToxValDB: a curated database that compiles quantitative toxicity values for chemicals from diverse public sources to support toxicological research and risk assessment.
☉ TOXRIC: a comprehensive, free-to-access, online database providing toxicological/feature data. The toxicity labels are retrieved from this database. [PMID: 36400569]

Chemically structural similarity

Similar Active Natural Products in NPASS

Top-200 similar NPs were calculated against the active-NP-set (includes approximately 50,000 NPs with experimentally-derived bioactivity available in NPASS)

Similarity is measured using the Tanimoto coefficient (Tc) , which compares the binary fingerprints of two molecules. Tc is calculated as the intersection divided by the union of '1' bits in the fingerprints, ranging from 0 to 1, with 1 indicating highest similarity.

● The left chart: Distribution of similarity level between NPC478931 and all remaining natural products in the NPASS database.
● The right table: Most similar natural products (Tc>=0.5 or Top200).

Similarity Score	Similarity Level	Natural Product ID

Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

● The left chart: Distribution of similarity level between NPC478931 and all drugs/candidates.
● The right table: Most similar clinical/approved drugs (Tc>=0.5 or Top200).

Similarity Score	Similarity Level	Drug ID	Developmental Stage

Bioactivity similarity

Similar Natural Products in NPASS

Similarity level is defined by Bioactivity similarity was calculated based on bioactivity descriptors of compounds. The bioactivity descriptors were calculated by a recently developed AI algorithm Chemical Checker (CC) [Nature Biotechnology, 38:1087–1096, 2020; Nature Communications, 12:3932, 2021], which evaluated bioactivity similarities at five levels:
☉ A: chemistry similarity;
☉ B: biological targets similarity;
☉ C: networks similarity;
☉ D: cell-based bioactivity similarity;
☉ E: similarity based on clinical data.
Those 5 categories of CC bioactivity descriptors were calculated and then subjected to manifold projection using UMAP algorithm, to project all NPs on a 2-Dimensional space. The current NP was highlighted with a small circle in the 2-D map. Below figures: left-to-right, A-to-E.

A: chemistry similarity

B: biological targets similarity

C: networks similarity

D: cell-based bioactivity similarity

E: similarity based on clinical data