Natural Product: NPC65155

Natural Product ID:  NPC65155
Common Name:   Momordicoside F2
IUPAC Name:  
Synonyms:   Momordicoside F2
Molecular Formula:   C36H58O8
Standard InCHIKey:  KJEYALWPYVKAPR-YBZIVOIYSA-N
Standard InCHI:  InChI=1S/C36H58O8/c1-21(9-8-14-31(2,3)41)22-12-15-34(7)24-13-16-36-25(35(24,20-42-36)18-17-33(22,34)6)10-11-26(32(36,4)5)44-30-29(40)28(39)27(38)23(19-37)43-30/h8,13-14,16,21-30,37-41H,9-12,15,17-20H2,1-7H3/b14-8+/t21-,22-,23-,24+,25+,26+,27-,28-,29-,30+,33-,34+,35+,36-/m1/s1
Canonical SMILES:  OC[C@H]1O[C@@H](O[C@H]2CC[C@@H]3[C@@]4(C2(C)C)C=C[C@@H]2[C@@]3(CO4)CC[C@]3([C@@]2(C)CC[C@@H]3[C@@H](C/C=C/C(O)(C)C)C)C)[C@@H]([C@@H]([C@@H]1O)O)O
First Find Year:  
Max Developmental Stage:  
Synthetic Gene Cluster:   ;

  Species Source

Organism ID Organism Name Taxonomy Level Family SuperKingdom Isolation Part Collection Location Collection Time Reference
NPO8182 Momordica charantia Species Cucurbitaceae Eukaryota PMID[17685651]

  Biological Activity

Target ID Target Type Target Name Target Organism Activity Type Activity Relation Value Unit Reference
NPT2 Others Unspecified Inhibition = 12.5 % 22497764
NPT2 Others Unspecified Inhibition = 9.1 % 25442304
NPT80 Cell Line Raji Homo sapiens Activity = 70 % 19729316
NPT2 Others Unspecified Inhibition = 29.7 % 10924160
NPT2 Others Unspecified Inhibition = 100 % 22850213
NPT2 Others Unspecified Inhibition = 76.9 % 10096871

  Similar Natural Products in NPASS

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient

●  The left chart: Distribution of similarity level between NPC65155 and all remaining natural products in the NPASS database.
●  The right table: Most similar natural products (Tc>=0.56 or Top200).

Similarity Score Similarity Level Natural Product ID
0.9901 High Similarity NPC473328
0.9901 High Similarity NPC473318
0.9901 High Similarity NPC28844
0.9804 High Similarity NPC191439
0.9804 High Similarity NPC103627
0.9804 High Similarity NPC170974
0.9615 High Similarity NPC231797
0.9519 High Similarity NPC208189
0.9519 High Similarity NPC65034
0.9429 High Similarity NPC473567
0.9429 High Similarity NPC216595
0.9327 High Similarity NPC157530
0.9327 High Similarity NPC14630
0.9327 High Similarity NPC250089
0.932 High Similarity NPC33053
0.9307 High Similarity NPC37207
0.9307 High Similarity NPC300399
0.9307 High Similarity NPC471482
0.9216 High Similarity NPC471885
0.9216 High Similarity NPC471887
0.9216 High Similarity NPC471886
0.9216 High Similarity NPC471888
0.9126 High Similarity NPC75608
0.9126 High Similarity NPC93352
0.9065 High Similarity NPC475354
0.9048 High Similarity NPC472896
0.9048 High Similarity NPC472897
0.9048 High Similarity NPC80210
0.9048 High Similarity NPC38376
0.9048 High Similarity NPC235824
0.9038 High Similarity NPC472900
0.9038 High Similarity NPC472898
0.9038 High Similarity NPC472899
0.9029 High Similarity NPC213190
0.902 High Similarity NPC21568
0.902 High Similarity NPC285231
0.8981 High Similarity NPC51154
0.8972 High Similarity NPC13190
0.8962 High Similarity NPC195116
0.8962 High Similarity NPC285253
0.8962 High Similarity NPC221110
0.8962 High Similarity NPC180459
0.8962 High Similarity NPC472901
0.8952 High Similarity NPC231340
0.8952 High Similarity NPC226642
0.8942 High Similarity NPC475365
0.8889 High Similarity NPC112274
0.8857 High Similarity NPC26798
0.8846 High Similarity NPC473198
0.8846 High Similarity NPC471450
0.8835 High Similarity NPC309425
0.8835 High Similarity NPC88000
0.8835 High Similarity NPC160734
0.8835 High Similarity NPC129372
0.8835 High Similarity NPC472023
0.8835 High Similarity NPC470434
0.8835 High Similarity NPC47566
0.8835 High Similarity NPC4831
0.8824 High Similarity NPC216260
0.8824 High Similarity NPC5358
0.8796 High Similarity NPC157474
0.8796 High Similarity NPC110494
0.8796 High Similarity NPC473021
0.8796 High Similarity NPC472987
0.8785 High Similarity NPC128133
0.8772 High Similarity NPC41129
0.8762 High Similarity NPC221562
0.8762 High Similarity NPC187400
0.8762 High Similarity NPC470885
0.875 High Similarity NPC136816
0.875 High Similarity NPC471889
0.8739 High Similarity NPC20979
0.8739 High Similarity NPC100048
0.8739 High Similarity NPC476690
0.8738 High Similarity NPC469942
0.8738 High Similarity NPC7341
0.8738 High Similarity NPC473200
0.8727 High Similarity NPC11548
0.8725 High Similarity NPC240372
0.8716 High Similarity NPC476305
0.8716 High Similarity NPC473125
0.8716 High Similarity NPC477050
0.8704 High Similarity NPC141433
0.8704 High Similarity NPC472717
0.8692 High Similarity NPC476538
0.8692 High Similarity NPC476541
0.8692 High Similarity NPC476540
0.8692 High Similarity NPC476539
0.8692 High Similarity NPC220427
0.8667 High Similarity NPC473123
0.8667 High Similarity NPC245280
0.8667 High Similarity NPC473020
0.8667 High Similarity NPC189852
0.8667 High Similarity NPC16520
0.8667 High Similarity NPC157659
0.8667 High Similarity NPC114874
0.8667 High Similarity NPC155010
0.8667 High Similarity NPC286969
0.8667 High Similarity NPC120123
0.8667 High Similarity NPC31907
0.8667 High Similarity NPC472252
0.8667 High Similarity NPC473124
0.8667 High Similarity NPC8039
0.8667 High Similarity NPC131479
0.8667 High Similarity NPC211879
0.8661 High Similarity NPC10366
0.8661 High Similarity NPC475403
0.8661 High Similarity NPC160888
0.8649 High Similarity NPC477029
0.8649 High Similarity NPC477030
0.8641 High Similarity NPC280825
0.8641 High Similarity NPC158088
0.8641 High Similarity NPC234287
0.8636 High Similarity NPC44298
0.8636 High Similarity NPC469348
0.8636 High Similarity NPC40133
0.8636 High Similarity NPC290608
0.8636 High Similarity NPC473128
0.8636 High Similarity NPC469347
0.8636 High Similarity NPC49413
0.8627 High Similarity NPC90583
0.8624 High Similarity NPC197231
0.8624 High Similarity NPC472715
0.8611 High Similarity NPC477027
0.8611 High Similarity NPC306131
0.8611 High Similarity NPC477026
0.8611 High Similarity NPC476835
0.8611 High Similarity NPC475670
0.8611 High Similarity NPC70204
0.8598 High Similarity NPC190395
0.8585 High Similarity NPC31430
0.8585 High Similarity NPC110656
0.8585 High Similarity NPC85593
0.8585 High Similarity NPC165033
0.8585 High Similarity NPC312774
0.8585 High Similarity NPC273879
0.8585 High Similarity NPC203354
0.8585 High Similarity NPC473127
0.8584 High Similarity NPC476085
0.8584 High Similarity NPC473633
0.8584 High Similarity NPC477071
0.8571 High Similarity NPC157376
0.8571 High Similarity NPC473852
0.8571 High Similarity NPC77319
0.8571 High Similarity NPC272015
0.8571 High Similarity NPC158344
0.8571 High Similarity NPC27507
0.8571 High Similarity NPC243196
0.8571 High Similarity NPC159036
0.8571 High Similarity NPC87250
0.8571 High Similarity NPC196429
0.8571 High Similarity NPC203862
0.8571 High Similarity NPC34390
0.8571 High Similarity NPC471353
0.8571 High Similarity NPC471354
0.8571 High Similarity NPC312553
0.8571 High Similarity NPC474418
0.8571 High Similarity NPC84987
0.8571 High Similarity NPC93883
0.8571 High Similarity NPC471355
0.8571 High Similarity NPC471351
0.8571 High Similarity NPC99728
0.8571 High Similarity NPC50305
0.8571 High Similarity NPC309034
0.8571 High Similarity NPC244402
0.8571 High Similarity NPC142066
0.8571 High Similarity NPC288694
0.8558 High Similarity NPC324598
0.8558 High Similarity NPC64348
0.8545 High Similarity NPC472716
0.8545 High Similarity NPC19888
0.8545 High Similarity NPC42171
0.8544 High Similarity NPC473890
0.8544 High Similarity NPC243728
0.8515 High Similarity NPC27531
0.8509 High Similarity NPC475629
0.8509 High Similarity NPC475556
0.8509 High Similarity NPC50689
0.8505 High Similarity NPC474015
0.8505 High Similarity NPC473199
0.8505 High Similarity NPC208594
0.8505 High Similarity NPC152584
0.8505 High Similarity NPC160816
0.8505 High Similarity NPC309448
0.8505 High Similarity NPC473923
0.8505 High Similarity NPC473476
0.8505 High Similarity NPC269627
0.8505 High Similarity NPC181845
0.8505 High Similarity NPC194842
0.8505 High Similarity NPC208477
0.8505 High Similarity NPC127801
0.8505 High Similarity NPC69737
0.8505 High Similarity NPC242748
0.8496 Intermediate Similarity NPC45475
0.8496 Intermediate Similarity NPC83287
0.8491 Intermediate Similarity NPC162354
0.8491 Intermediate Similarity NPC16573
0.8491 Intermediate Similarity NPC475701
0.8482 Intermediate Similarity NPC310341
0.8482 Intermediate Similarity NPC207637

  Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

●  The left chart: Distribution of similarity level between NPC65155 and all drugs/candidates.
●  The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).

Similarity Score Similarity Level Drug ID Developmental Stage
0.8496 Intermediate Similarity NPD7327 Approved
0.8496 Intermediate Similarity NPD7328 Approved
0.8435 Intermediate Similarity NPD8296 Approved
0.8435 Intermediate Similarity NPD8378 Approved
0.8435 Intermediate Similarity NPD8335 Approved
0.8435 Intermediate Similarity NPD8379 Approved
0.8435 Intermediate Similarity NPD8380 Approved
0.8421 Intermediate Similarity NPD7516 Approved
0.8348 Intermediate Similarity NPD8294 Approved
0.8348 Intermediate Similarity NPD8377 Approved
0.8276 Intermediate Similarity NPD8033 Approved
0.812 Intermediate Similarity NPD7503 Approved
0.7851 Intermediate Similarity NPD7507 Approved
0.7805 Intermediate Similarity NPD7319 Approved
0.7521 Intermediate Similarity NPD8133 Approved
0.7477 Intermediate Similarity NPD8171 Discontinued
0.7456 Intermediate Similarity NPD6412 Phase 2
0.7391 Intermediate Similarity NPD6686 Approved
0.7317 Intermediate Similarity NPD6370 Approved
0.7302 Intermediate Similarity NPD7736 Approved
0.7236 Intermediate Similarity NPD8515 Approved
0.7236 Intermediate Similarity NPD8516 Approved
0.7236 Intermediate Similarity NPD8517 Approved
0.7236 Intermediate Similarity NPD8513 Phase 3
0.7179 Intermediate Similarity NPD8132 Clinical (unspecified phase)
0.717 Intermediate Similarity NPD7524 Approved
0.7154 Intermediate Similarity NPD6054 Approved
0.7087 Intermediate Similarity NPD8293 Discontinued
0.708 Intermediate Similarity NPD7640 Approved
0.708 Intermediate Similarity NPD7639 Approved
0.7049 Intermediate Similarity NPD7115 Discovery
0.7048 Intermediate Similarity NPD7338 Clinical (unspecified phase)
0.7016 Intermediate Similarity NPD6059 Approved
0.6991 Remote Similarity NPD7638 Approved
0.699 Remote Similarity NPD7525 Registered
0.696 Remote Similarity NPD6016 Approved
0.696 Remote Similarity NPD6015 Approved
0.6952 Remote Similarity NPD6695 Phase 3
0.6947 Remote Similarity NPD8449 Approved
0.6929 Remote Similarity NPD7492 Approved
0.6905 Remote Similarity NPD5988 Approved
0.6894 Remote Similarity NPD8450 Suspended
0.6875 Remote Similarity NPD6616 Approved
0.6852 Remote Similarity NPD7750 Discontinued
0.685 Remote Similarity NPD8328 Phase 3
0.6838 Remote Similarity NPD8170 Clinical (unspecified phase)
0.6827 Remote Similarity NPD6928 Phase 2
0.6822 Remote Similarity NPD7078 Approved
0.6777 Remote Similarity NPD8413 Clinical (unspecified phase)
0.6774 Remote Similarity NPD8295 Clinical (unspecified phase)
0.675 Remote Similarity NPD4061 Clinical (unspecified phase)
0.6724 Remote Similarity NPD5344 Discontinued
0.6721 Remote Similarity NPD6882 Approved
0.6721 Remote Similarity NPD8297 Approved
0.6719 Remote Similarity NPD6067 Discontinued
0.6697 Remote Similarity NPD4751 Clinical (unspecified phase)
0.6696 Remote Similarity NPD4225 Approved
0.6667 Remote Similarity NPD6931 Approved
0.6667 Remote Similarity NPD7514 Phase 3
0.6667 Remote Similarity NPD6930 Phase 2
0.6667 Remote Similarity NPD7625 Phase 1
0.6667 Remote Similarity NPD5345 Clinical (unspecified phase)
0.664 Remote Similarity NPD6009 Approved
0.6614 Remote Similarity NPD6319 Approved
0.6581 Remote Similarity NPD4159 Approved
0.6571 Remote Similarity NPD6929 Approved
0.6571 Remote Similarity NPD7645 Phase 2
0.6565 Remote Similarity NPD8074 Phase 3
0.6557 Remote Similarity NPD5955 Clinical (unspecified phase)
0.6532 Remote Similarity NPD4632 Approved
0.6525 Remote Similarity NPD7632 Discontinued
0.6515 Remote Similarity NPD6033 Approved
0.6509 Remote Similarity NPD7332 Phase 2
0.6505 Remote Similarity NPD7339 Approved
0.6505 Remote Similarity NPD6942 Approved
0.6476 Remote Similarity NPD7145 Approved
0.646 Remote Similarity NPD7637 Suspended
0.646 Remote Similarity NPD7087 Discontinued
0.6449 Remote Similarity NPD6902 Approved
0.6429 Remote Similarity NPD6051 Approved
0.641 Remote Similarity NPD8029 Clinical (unspecified phase)
0.6393 Remote Similarity NPD6899 Approved
0.6393 Remote Similarity NPD7320 Approved
0.6393 Remote Similarity NPD6881 Approved
0.6387 Remote Similarity NPD5211 Phase 2
0.6381 Remote Similarity NPD5776 Phase 2
0.6381 Remote Similarity NPD6932 Approved
0.6381 Remote Similarity NPD6925 Approved
0.6371 Remote Similarity NPD6650 Approved
0.6371 Remote Similarity NPD6649 Approved
0.6371 Remote Similarity NPD8130 Phase 1
0.6364 Remote Similarity NPD6402 Approved
0.6364 Remote Similarity NPD6893 Approved
0.6364 Remote Similarity NPD6675 Approved
0.6364 Remote Similarity NPD7128 Approved
0.6364 Remote Similarity NPD5739 Approved
0.6356 Remote Similarity NPD6648 Approved
0.6341 Remote Similarity NPD6372 Approved
0.6341 Remote Similarity NPD6373 Approved
0.6311 Remote Similarity NPD5954 Clinical (unspecified phase)
0.6311 Remote Similarity NPD5697 Approved
0.629 Remote Similarity NPD6883 Approved
0.629 Remote Similarity NPD7102 Approved
0.629 Remote Similarity NPD7290 Approved
0.629 Remote Similarity NPD4634 Approved
0.6286 Remote Similarity NPD6933 Approved
0.6286 Remote Similarity NPD3701 Clinical (unspecified phase)
0.6281 Remote Similarity NPD5141 Approved
0.6261 Remote Similarity NPD6399 Phase 3
0.624 Remote Similarity NPD6847 Approved
0.624 Remote Similarity NPD6617 Approved
0.624 Remote Similarity NPD6869 Approved
0.6231 Remote Similarity NPD7741 Discontinued
0.623 Remote Similarity NPD6008 Approved
0.623 Remote Similarity NPD6640 Phase 3
0.6218 Remote Similarity NPD5286 Approved
0.6218 Remote Similarity NPD4696 Approved
0.6218 Remote Similarity NPD5285 Approved
0.6212 Remote Similarity NPD7604 Phase 2
0.621 Remote Similarity NPD6012 Approved
0.621 Remote Similarity NPD6013 Approved
0.621 Remote Similarity NPD6014 Approved
0.619 Remote Similarity NPD6053 Discontinued
0.6186 Remote Similarity NPD4755 Approved
0.6183 Remote Similarity NPD6921 Approved
0.6183 Remote Similarity NPD5983 Phase 2
0.6179 Remote Similarity NPD5701 Approved
0.6176 Remote Similarity NPD4267 Clinical (unspecified phase)
0.6176 Remote Similarity NPD5956 Approved
0.6174 Remote Similarity NPD8034 Phase 2
0.6174 Remote Similarity NPD8035 Phase 2
0.6174 Remote Similarity NPD6079 Approved
0.6154 Remote Similarity NPD7991 Discontinued
0.6147 Remote Similarity NPD6898 Phase 1
0.614 Remote Similarity NPD5328 Approved
0.6136 Remote Similarity NPD5126 Approved
0.6136 Remote Similarity NPD5125 Phase 3
0.6129 Remote Similarity NPD6011 Approved
0.6126 Remote Similarity NPD6400 Clinical (unspecified phase)
0.6126 Remote Similarity NPD4786 Approved
0.6121 Remote Similarity NPD4202 Approved
0.6119 Remote Similarity NPD6336 Discontinued
0.6116 Remote Similarity NPD4633 Approved
0.6116 Remote Similarity NPD5225 Approved
0.6116 Remote Similarity NPD5226 Approved
0.6116 Remote Similarity NPD5224 Approved
0.6111 Remote Similarity NPD6683 Phase 2
0.6095 Remote Similarity NPD6924 Approved
0.6095 Remote Similarity NPD6926 Approved
0.6095 Remote Similarity NPD1811 Approved
0.6095 Remote Similarity NPD1810 Approved
0.6095 Remote Similarity NPD4785 Approved
0.6095 Remote Similarity NPD4784 Approved
0.6087 Remote Similarity NPD7838 Discovery
0.6087 Remote Similarity NPD3168 Discontinued
0.6083 Remote Similarity NPD4700 Approved
0.6068 Remote Similarity NPD7748 Approved
0.6066 Remote Similarity NPD5174 Approved
0.6066 Remote Similarity NPD5175 Approved
0.6058 Remote Similarity NPD4243 Approved
0.605 Remote Similarity NPD6084 Phase 2
0.605 Remote Similarity NPD7902 Approved
0.605 Remote Similarity NPD6083 Phase 2
0.6038 Remote Similarity NPD8264 Approved
0.6033 Remote Similarity NPD5223 Approved
0.6025 Remote Similarity NPD7799 Discontinued
0.6019 Remote Similarity NPD7322 Clinical (unspecified phase)
0.6018 Remote Similarity NPD3618 Phase 1
0.6 Remote Similarity NPD4730 Approved
0.6 Remote Similarity NPD4729 Approved
0.5984 Remote Similarity NPD6401 Clinical (unspecified phase)
0.5968 Remote Similarity NPD4768 Approved
0.5968 Remote Similarity NPD4767 Approved
0.5966 Remote Similarity NPD5221 Approved
0.5966 Remote Similarity NPD5222 Approved
0.5966 Remote Similarity NPD5220 Clinical (unspecified phase)
0.5965 Remote Similarity NPD4251 Approved
0.5965 Remote Similarity NPD4250 Approved
0.5948 Remote Similarity NPD6698 Approved
0.5948 Remote Similarity NPD46 Approved
0.5948 Remote Similarity NPD8522 Clinical (unspecified phase)
0.5946 Remote Similarity NPD3667 Approved
0.5929 Remote Similarity NPD7520 Clinical (unspecified phase)
0.592 Remote Similarity NPD7899 Clinical (unspecified phase)
0.5917 Remote Similarity NPD5173 Approved
0.5909 Remote Similarity NPD7509 Discontinued
0.5909 Remote Similarity NPD7100 Approved
0.5909 Remote Similarity NPD7101 Approved
0.5909 Remote Similarity NPD4748 Discontinued
0.5906 Remote Similarity NPD5248 Approved
0.5906 Remote Similarity NPD5251 Approved
0.5906 Remote Similarity NPD5247 Approved
0.5906 Remote Similarity NPD5250 Approved
0.5906 Remote Similarity NPD5249 Phase 3
0.5905 Remote Similarity NPD7152 Approved
0.5905 Remote Similarity NPD7151 Approved
0.5905 Remote Similarity NPD7150 Approved
0.5897 Remote Similarity NPD7515 Phase 2
0.5882 Remote Similarity NPD6356 Clinical (unspecified phase)
0.5877 Remote Similarity NPD4249 Approved

Structure

External Identifiers

PubChem CID   44445567
ChEMBL   CHEMBL245260
ZINC  

Physicochemical Properties

Molecular Weight:  618.41
ALogP:  0.0093
MLogP:  4.54
XLogP:  6.389
# Rotatable Bonds:  19
Polar Surface Area:  128.84
# H-Bond Aceptor:  8
# H-Bond Donor:  5
# Rings:  6
# Heavy Atoms:  44

Download Data

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General Info & Identifiers & Properties  
Structure MOL file  
Source Organisms  
Biological Activities  
Similar NPs/Drugs