CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	ADORA3; GPBAR1; ADORA2A; ADORA1;
Enzyme_unclassified	CDA; TK1; ADK; AKR1B10;
Lyase	CA7; CA12; CA9; CA13;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Transcription Factor	STAT6;
SLC superfamily of solute carriers	SLC28A2; SLC28A1; SLC28A3;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	CDA	Cytidine deaminase	P32320	CHEMBL4502
Enzyme_unclassified	TK1	Thymidine kinase, cytosolic	P04183	CHEMBL2883
Enzyme_unclassified	ADK	Adenosine kinase	P55263	CHEMBL3589
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA13	Carbonic anhydrase XIII	Q8N1Q1	CHEMBL3912
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	3.860E-08	1.201E-04	CA12, CA13, CA7, CA9
BP	GO:0009987; cellular process	GO:0001973; adenosine receptor signaling pathway	6.752E-08	1.634E-04	ADORA1, ADORA2A, ADORA3
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	8.851E-08	1.927E-04	CA12, CA13, CA7, CA9
BP	GO:0051179; localization	GO:0015860; purine nucleoside transmembrane transport	9.167E-07	1.174E-03	SLC28A2, SLC28A3
BP	GO:0051179; localization	GO:1904823; purine nucleobase transmembrane transport	2.748E-06	2.217E-03	SLC28A1, SLC28A3
BP	GO:0051179; localization	GO:0015855; pyrimidine nucleobase transport	2.748E-06	2.217E-03	SLC28A1, SLC28A3
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	2.748E-06	2.217E-03	GPBAR1, NR1H4
CC	GO:0044464; cell part	GO:0099056; integral component of presynaptic membrane	2.748E-06	2.217E-03	ADORA1, ADORA2A
CC	GO:0044456; synapse part	GO:0099055; integral component of postsynaptic membrane	3.286E-05	1.491E-02	ADORA1, ADORA2A
CC	GO:0043226; organelle	GO:0097504; Gemini of coiled bodies	6.015E-05	2.339E-02	SMN1, SMN2

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.373E-09	3.571E-08	CA12, CA7, CA9, CA13
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	8.632E-04	1.122E-02	CDA, TK1
09100 Metabolism	09104 Nucleotide metabolism	hsa00240	Pyrimidine metabolism	4.404E-03	2.863E-02	CDA, TK1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	2.813E-02	7.086E-02	AKR1B10
09120 Genetic Information Processing	09122 Translation	hsa03013	RNA transport	1.142E-02	4.243E-02	SMN2, SMN1
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	2.161E-03	1.873E-02	ADORA2A, ADORA3, ADORA1
09130 Environmental Information Processing	09132 Signal transduction	hsa04071	Sphingolipid signaling pathway	5.711E-03	2.970E-02	ADORA3, ADORA1
09130 Environmental Information Processing	09132 Signal transduction	hsa04022	cGMP-PKG signaling pathway	1.080E-02	4.243E-02	ADORA3, ADORA1
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	1.507E-02	4.898E-02	ADORA2A, ADORA1
Unclassified	Unclassified	hsa01100	Metabolic pathways	2.690E-02	7.086E-02	CDA, AKR1B10, ADK, TK1

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	ADORA3;
A00-B99: Certain infectious and parasitic diseases	Sepsis	A40, A41	ADORA1;
A00-B99: Certain infectious and parasitic diseases	Adult varicella zoster virus infection	B02	TK1;
C00-D49: Neoplasms	Cancer	C00-C96	TK1; ADORA3; CA9;
C00-D49: Neoplasms	Solid tumours	C00-D48	TK1; CDA; CA9;
C00-D49: Neoplasms	Breast cancer	C50	CA9;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	ADORA3;
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9;
C00-D49: Neoplasms	Pancreatic cancer	C25	TK1;
C00-D49: Neoplasms	Renal cancer	C64	CA9;

Showing 1 to 10 of 49 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Hydrangea macrophylla

Taxonomic Information:

Plant External Links:

Used in Medicines:

Country/Region:

Traditional Medicine System:

Medicinal Functions:

Geographical Distribution:

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Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities