CMAUP Plant Collective Molecular Activities

Plant Name: Hydrangea macrophylla

Taxonomic Information:

Plant ID: NPO9360
Plant Latin Name: Hydrangea macrophylla
Taxonomy Genus: Hydrangea
Taxonomy Family: Hydrangeaceae

Plant External Links:

NCBI TaxonomyDB: 23110
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China; Indonesia; India

Traditional Medicine System:

Indian Folk; TCM

Medicinal Functions:

Antiperiodic; Antitussive; Diuretic

Geographical Distribution:

India; Indonesia; China

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	ADORA3; GPBAR1; ADORA2A; ADORA1;
Enzyme_unclassified	CDA; TK1; ADK; AKR1B10;
Lyase	CA7; CA12; CA9; CA13;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Transcription Factor	STAT6;
SLC superfamily of solute carriers	SLC28A2; SLC28A1; SLC28A3;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	CDA	Cytidine deaminase	P32320	CHEMBL4502
Enzyme_unclassified	TK1	Thymidine kinase, cytosolic	P04183	CHEMBL2883
Enzyme_unclassified	ADK	Adenosine kinase	P55263	CHEMBL3589
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA13	Carbonic anhydrase XIII	Q8N1Q1	CHEMBL3912
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
SLC superfamily of solute carriers	SLC28A2	Sodium/nucleoside cotransporter 2	O43868	CHEMBL5780
SLC superfamily of solute carriers	SLC28A1	Sodium/nucleoside cotransporter 1	O00337	CHEMBL5551
SLC superfamily of solute carriers	SLC28A3	Solute carrier family 28 member 3	Q9HAS3	CHEMBL5707
Small molecule receptor (family A GPCR)	ADORA3	Adenosine A3 receptor	P0DMS8	CHEMBL256
Small molecule receptor (family A GPCR)	GPBAR1	G-protein coupled bile acid receptor 1	Q8TDU6	CHEMBL5409
Small molecule receptor (family A GPCR)	ADORA2A	Adenosine A2a receptor	P29274	CHEMBL251
Small molecule receptor (family A GPCR)	ADORA1	Adenosine A1 receptor	P30542	CHEMBL226
Transcription Factor	STAT6	Signal transducer and activator of transcription 6	P42226	CHEMBL5401

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	9.062E-10	9.866E-06	CA12, CA13, CA7, CA9
MF	GO:0060089; molecular transducer activity	GO:0001609; G-protein coupled adenosine receptor activity	2.817E-08	1.022E-04	ADORA1, ADORA2A, ADORA3
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	3.860E-08	1.201E-04	CA12, CA13, CA7, CA9
BP	GO:0009987; cellular process	GO:0001973; adenosine receptor signaling pathway	6.752E-08	1.634E-04	ADORA1, ADORA2A, ADORA3
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	8.851E-08	1.927E-04	CA12, CA13, CA7, CA9
BP	GO:0051179; localization	GO:0015860; purine nucleoside transmembrane transport	9.167E-07	1.174E-03	SLC28A2, SLC28A3
MF	GO:0005215; transporter activity	GO:0015389; pyrimidine- and adenine-specific:sodium symporter activity	9.167E-07	1.174E-03	SLC28A1, SLC28A3
MF	GO:0005215; transporter activity	GO:0015211; purine nucleoside transmembrane transporter activity	9.167E-07	1.174E-03	SLC28A2, SLC28A3
BP	GO:0051179; localization	GO:1904823; purine nucleobase transmembrane transport	2.748E-06	2.217E-03	SLC28A1, SLC28A3
BP	GO:0051179; localization	GO:0015855; pyrimidine nucleobase transport	2.748E-06	2.217E-03	SLC28A1, SLC28A3
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	2.748E-06	2.217E-03	GPBAR1, NR1H4
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	2.748E-06	2.217E-03	GPBAR1, NR1H4
CC	GO:0044464; cell part	GO:0099056; integral component of presynaptic membrane	2.748E-06	2.217E-03	ADORA1, ADORA2A
MF	GO:0005488; binding	GO:0008270; zinc ion binding	7.370E-06	5.015E-03	CA12, CA13, CA7, CA9, CDA, NR1H4, TK1
CC	GO:0044456; synapse part	GO:0099055; integral component of postsynaptic membrane	3.286E-05	1.491E-02	ADORA1, ADORA2A
CC	GO:0043226; organelle	GO:0097504; Gemini of coiled bodies	6.015E-05	2.339E-02	SMN1, SMN2
CC	GO:0032991; macromolecular complex	GO:0032797; SMN complex	7.104E-05	2.622E-02	SMN1, SMN2
CC	GO:0044464; cell part	GO:0030673; axolemma	1.091E-04	3.832E-02	ADORA1, ADORA2A

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.373E-09	3.571E-08	CA12, CA7, CA9, CA13
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	8.632E-04	1.122E-02	CDA, TK1
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	2.161E-03	1.873E-02	ADORA2A, ADORA3, ADORA1
09100 Metabolism	09104 Nucleotide metabolism	hsa00240	Pyrimidine metabolism	4.404E-03	2.863E-02	CDA, TK1
09130 Environmental Information Processing	09132 Signal transduction	hsa04071	Sphingolipid signaling pathway	5.711E-03	2.970E-02	ADORA3, ADORA1
09130 Environmental Information Processing	09132 Signal transduction	hsa04022	cGMP-PKG signaling pathway	1.080E-02	4.243E-02	ADORA3, ADORA1
09120 Genetic Information Processing	09122 Translation	hsa03013	RNA transport	1.142E-02	4.243E-02	SMN2, SMN1
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	1.507E-02	4.898E-02	ADORA2A, ADORA1
Unclassified	Unclassified	hsa01100	Metabolic pathways	2.690E-02	7.086E-02	CDA, AKR1B10, ADK, TK1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	2.813E-02	7.086E-02	AKR1B10

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
E00-E89: Endocrine, nutritional and metabolic diseases	Atrial fibrillation	E78, I48	ADORA1;
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	ADORA1; ADORA2A;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	ADORA1;
E00-E89: Endocrine, nutritional and metabolic diseases	Hypertriglyceridemia	E78.1, E78.2, E78.3, I47-I49	ADORA1;
C00-D49: Neoplasms	Cancer	C00-C96	TK1; ADORA3; CA9;
C00-D49: Neoplasms	Solid tumours	C00-D48	TK1; CDA; CA9;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ADORA2A; ADK;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	ADORA3;
G00-G99: Diseases of the nervous system G00-G99	Epilepsy	G40	ADK;
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ADK;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ADORA1; ADORA2A;
I00-I99: Diseases of the circulatory system	Arteriosclerosis	I70	ADORA2A;
A00-B99: Certain infectious and parasitic diseases	Sepsis	A40, A41	ADORA1;
I00-I99: Diseases of the circulatory system	Heart failure	I50	ADORA1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	ADORA1;
C00-D49: Neoplasms	Breast cancer	C50	CA9;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	ADORA3;
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	ADORA1;
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ADORA1; ADORA2A; ADORA3;
L00-L99: Diseases of the skin and subcutaneous tissue	Diabetic foot ulcer	L88-L89	ADORA2A;
I00-I99: Diseases of the circulatory system	Acute and chronic heart failure	I50	ADORA1;
J00-J99: Diseases of the respiratory system	Asthma	J45	ADORA1; ADORA2A;
I00-I99: Diseases of the circulatory system	Cardiac arrhythmias	I47-I49	ADORA1;
I00-I99: Diseases of the circulatory system	Orthostatic hypotension	I95.1	ADORA1;
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	ADORA3;
I00-I99: Diseases of the circulatory system	Ischemia	I99.8	ADORA3;
C00-D49: Neoplasms	Pancreatic cancer	C25	TK1;
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	ADORA3;
C00-D49: Neoplasms	Renal cancer	C64	CA9;
NA: NA	Hepatitis C virus infection	NA	ADORA3;
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	ADORA2A;
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ADORA1;
N00-N99: Diseases of the genitourinary system	Renal failure	N17, N18, N19	ADORA1;
S00-T88: Injury, poisoning and certain other consequences of external causes	Graft-versus-host disease	T86.0	TK1;
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	ADORA1; ADORA2A;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TK1;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Fatigue	R53	ADORA1;
I00-I99: Diseases of the circulatory system	Cardiac disease	I00-I99	ADORA1;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Radionuclide imaging	W88	ADORA2A;
C00-D49: Neoplasms	Prostate cancer	C61	TK1;
G00-G99: Diseases of the nervous system G00-G99	Multiple scierosis	G35	ADORA1;
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	ADORA2A;
S00-T88: Injury, poisoning and certain other consequences of external causes	Allergy	T78.4	ADORA1;
A00-B99: Certain infectious and parasitic diseases	Adult varicella zoster virus infection	B02	TK1;
C00-D49: Neoplasms	Brain cancer	C71, D33	TK1;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Convulsions	R56.0	ADK;
I00-I99: Diseases of the circulatory system	Coronary disorder diagnosis	I20-I25	ADORA2A;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases