Plant Name: Hydrangea macrophylla
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 3.860E-08 | 1.201E-04 | CA12, CA13, CA7, CA9 |
| BP | GO:0009987; cellular process | GO:0001973; adenosine receptor signaling pathway | 6.752E-08 | 1.634E-04 | ADORA1, ADORA2A, ADORA3 |
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 8.851E-08 | 1.927E-04 | CA12, CA13, CA7, CA9 |
| BP | GO:0051179; localization | GO:0015860; purine nucleoside transmembrane transport | 9.167E-07 | 1.174E-03 | SLC28A2, SLC28A3 |
| BP | GO:0051179; localization | GO:1904823; purine nucleobase transmembrane transport | 2.748E-06 | 2.217E-03 | SLC28A1, SLC28A3 |
| BP | GO:0051179; localization | GO:0015855; pyrimidine nucleobase transport | 2.748E-06 | 2.217E-03 | SLC28A1, SLC28A3 |
| BP | GO:0009987; cellular process | GO:0038183; bile acid signaling pathway | 2.748E-06 | 2.217E-03 | GPBAR1, NR1H4 |
| CC | GO:0044464; cell part | GO:0099056; integral component of presynaptic membrane | 2.748E-06 | 2.217E-03 | ADORA1, ADORA2A |
| MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 9.062E-10 | 9.866E-06 | CA12, CA13, CA7, CA9 |
| MF | GO:0060089; molecular transducer activity | GO:0001609; G-protein coupled adenosine receptor activity | 2.817E-08 | 1.022E-04 | ADORA1, ADORA2A, ADORA3 |
Showing 1 to 10 of 14 entries
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00240 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 4.404E-03 | 2.863E-02 | CDA; TK1 |
| hsa00910 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.373E-09 | 3.571E-08 | CA12; CA7; CA9; CA13 |
| hsa00983 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 8.632E-04 | 1.122E-02 | CDA; TK1 |
| hsa03013 | RNA transport_Homo sapiens_hsa03013 | 1.142E-02 | 4.243E-02 | SMN2; SMN1 |
| hsa04022 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 1.080E-02 | 4.243E-02 | ADORA3; ADORA1 |
| hsa04024 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.507E-02 | 4.898E-02 | ADORA2A; ADORA1 |
| hsa04071 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 5.711E-03 | 2.970E-02 | ADORA3; ADORA1 |
| hsa04080 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 2.161E-03 | 1.873E-02 | ADORA2A; ADORA3; ADORA1 |
Showing 1 to 8 of 8 entries
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| A00-B99: Certain infectious and parasitic diseases | Malaria | B54 | ADORA3 |
| A00-B99: Certain infectious and parasitic diseases | Sepsis | A40, A41 | ADORA1 |
| A00-B99: Certain infectious and parasitic diseases | Adult varicella zoster virus infection | B02 | TK1 |
| C00-D49: Neoplasms | Cancer | C00-C96 | CA9; ADORA3; TK1 |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | CA9; CDA; TK1 |
| C00-D49: Neoplasms | Breast cancer | C50 | CA9 |
| C00-D49: Neoplasms | Hepatocellular carcinoma | C22.0 | ADORA3 |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | CA9 |
| C00-D49: Neoplasms | Pancreatic cancer | C25 | TK1 |
| C00-D49: Neoplasms | Renal cancer | C64 | CA9 |
Showing 1 to 10 of 52 entries