CMAUP Plant Collective Molecular Activities

Plant Name: Porophyllum ruderale

Taxonomic Information:

Plant ID: NPO8286
Plant Latin Name: Porophyllum ruderale
Taxonomy Genus: Porophyllum
Taxonomy Family: Asteraceae

Plant External Links:

NCBI TaxonomyDB: 169599
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Argentina

Traditional Medicine System:

Geographical Distribution:

Argentina

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Hydrolase	ACHE;
Enzyme_unclassified	ALDH1A1;
Unclassified	LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0042737; drug catabolic process	2.056E-04	3.006E-01	ACHE, CYP3A4
MF	GO:0005488; binding	GO:0042562; hormone binding	1.142E-04	3.006E-01	ACHE, ALDH1A1
MF	GO:0003824; catalytic activity	GO:0003990; acetylcholinesterase activity	4.141E-04	4.099E-01	ACHE
CC	GO:0044464; cell part	GO:0005635; nuclear envelope	3.333E-02	1.000E+00	LMNA

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	6.214E-05	9.321E-04	ALDH1A1, CYP3A4
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	5.788E-03	2.358E-02	CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	9.169E-03	2.358E-02	CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.373E-02	2.358E-02	CYP3A4
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1.155E-02	2.358E-02	CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.452E-02	2.358E-02	CYP3A4
09160 Human Diseases	09165 Cardiovascular diseases	hsa05414	Dilated cardiomyopathy	1.788E-02	2.358E-02	LMNA
09160 Human Diseases	09165 Cardiovascular diseases	hsa05410	Hypertrophic cardiomyopathy (HCM)	1.650E-02	2.358E-02	LMNA
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.630E-02	2.358E-02	CYP3A4
09100 Metabolism	09103 Lipid metabolism	hsa00564	Glycerophospholipid metabolism	1.887E-02	2.358E-02	ACHE

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases