CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ACHE; ACHE; ACHE
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE
NA: NA	Upper abdominal bloating	NA	ACHE
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ACHE
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	ACHE
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	CYP3A4; ACHE
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ACHE
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE
C00-D49: Neoplasms	Cancer	C00-C96	ACHE
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Porophyllum ruderale

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Human Protein Targets

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases