CMAUP Plant Collective Molecular Activities

Plant Name: Aconitum japonicum

Taxonomic Information:

Plant ID: NPO7490
Plant Latin Name: Aconitum japonicum
Taxonomy Genus: Aconitum
Taxonomy Family: Ranunculaceae

Plant External Links:

NCBI TaxonomyDB: 1478108
Plant-of-the-World-Online: 707472-1

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Medicinal Functions:

Analgesic; Antirheumatic

Geographical Distribution:

Japan; China

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	CNR1; GPBAR1; DRD3; DRD2; CNR2; DRD4;
Lyase	CA2; CA1; CA12; CA9; CA7; CA3; CA14; CA5B; CA5A; CA4; CA6;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Nuclear hormone receptor subfamily 3 group A	ESR2;
Nuclear hormone receptor subfamily 2 group B	RXRA;
Oxidoreductase	ALOX5;
Enzyme_unclassified	AKR1B10; HSD17B10;
Transcription Factor	HIF1A;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA3	Carbonic anhydrase III	P07451	CHEMBL2885
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA5B	Carbonic anhydrase VB	Q9Y2D0	CHEMBL3969
Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Nuclear hormone receptor subfamily 2 group B	RXRA	Retinoid X receptor alpha	P19793	CHEMBL2061
Nuclear hormone receptor subfamily 3 group A	ESR2	Estrogen receptor beta	Q92731	CHEMBL242
Oxidoreductase	ALOX5	Arachidonate 5-lipoxygenase	P09917	CHEMBL215
Small molecule receptor (family A GPCR)	CNR1	Cannabinoid CB1 receptor	P21554	CHEMBL218
Small molecule receptor (family A GPCR)	GPBAR1	G-protein coupled bile acid receptor 1	Q8TDU6	CHEMBL5409
Small molecule receptor (family A GPCR)	DRD3	Dopamine D3 receptor	P35462	CHEMBL234
Small molecule receptor (family A GPCR)	DRD2	Dopamine D2 receptor	P14416	CHEMBL217
Small molecule receptor (family A GPCR)	CNR2	Cannabinoid CB2 receptor	P34972	CHEMBL253
Small molecule receptor (family A GPCR)	DRD4	Dopamine D4 receptor	P21917	CHEMBL219
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0008270; zinc ion binding	1.923E-12	4.188E-09	CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR2, NR1H4, RXRA
BP	GO:0050896; response to stimulus	GO:0001975; response to amphetamine	2.690E-08	3.446E-05	CNR2, DRD2, DRD3, DRD4
MF	GO:0060089; molecular transducer activity	GO:0001591; dopamine neurotransmitter receptor activity, coupled via Gi/Go	9.399E-08	8.528E-05	DRD2, DRD3, DRD4
BP	GO:0009987; cellular process	GO:0007195; adenylate cyclase-inhibiting dopamine receptor signaling pathway	2.011E-07	1.631E-04	DRD2, DRD3, DRD4
BP	GO:0050896; response to stimulus	GO:0034776; response to histamine	2.763E-07	2.074E-04	DRD2, DRD3, DRD4
MF	GO:0005488; binding	GO:0035240; dopamine binding	4.781E-07	3.358E-04	DRD2, DRD3, DRD4
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	9.742E-31	2.121E-26	CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0007610; behavior	GO:0048148; behavioral response to cocaine	1.895E-06	1.006E-03	DRD2, DRD3, DRD4
BP	GO:0051179; localization	GO:0050482; arachidonic acid secretion	2.936E-06	1.390E-03	DRD2, DRD3, DRD4
BP	GO:0009987; cellular process	GO:0060160; negative regulation of dopamine receptor signaling pathway	4.435E-06	1.694E-03	DRD2, DRD3
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	4.435E-06	1.694E-03	CA2, CA7
BP	GO:0009987; cellular process	GO:0033602; negative regulation of dopamine secretion	4.435E-06	1.694E-03	CNR1, DRD2
BP	GO:0023052; signaling	GO:0051586; positive regulation of dopamine uptake involved in synaptic transmission	4.435E-06	1.694E-03	DRD2, DRD4
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	4.435E-06	1.694E-03	GPBAR1, NR1H4
MF	GO:0060089; molecular transducer activity	GO:0004949; cannabinoid receptor activity	4.435E-06	1.694E-03	CNR1, CNR2
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	4.435E-06	1.694E-03	GPBAR1, NR1H4
BP	GO:0008152; metabolic process	GO:0042417; dopamine metabolic process	5.410E-06	1.963E-03	DRD2, DRD3, DRD4
BP	GO:0065007; biological regulation	GO:0007194; negative regulation of adenylate cyclase activity	8.164E-06	2.653E-03	DRD2, DRD3, DRD4
BP	GO:0050896; response to stimulus	GO:0043278; response to morphine	8.164E-06	2.653E-03	CNR1, DRD2, DRD3
BP	GO:0009987; cellular process	GO:0038171; cannabinoid signaling pathway	8.864E-06	2.757E-03	CNR1, CNR2
BP	GO:0009987; cellular process	GO:0050709; negative regulation of protein secretion	1.413E-05	3.894E-03	DRD2, DRD3, DRD4, NR1H4
BP	GO:0040011; locomotion	GO:0090325; regulation of locomotion involved in locomotory behavior	1.476E-05	4.005E-03	DRD2, DRD3
BP	GO:0065007; biological regulation	GO:0045776; negative regulation of blood pressure	1.874E-05	4.691E-03	CNR1, DRD2, DRD3
BP	Unclassified;	GO:0032415; regulation of sodium:proton antiporter activity	2.213E-05	5.071E-03	DRD3, DRD4
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	2.213E-05	5.071E-03	CA1, CA2
BP	GO:0007610; behavior	GO:0008542; visual learning	2.810E-05	5.883E-03	DRD2, DRD3, HIF1A
MF	GO:0140110; transcription regulator activity	GO:0004879; nuclear receptor activity	2.991E-05	6.030E-03	ESR2, NR1H4, RXRA
BP	GO:0008152; metabolic process	GO:0051001; negative regulation of nitric-oxide synthase activity	3.095E-05	6.127E-03	CNR1, CNR2
MF	GO:0060089; molecular transducer activity	GO:0003707; steroid hormone receptor activity	5.234E-05	9.578E-03	ESR2, NR1H4, RXRA
BP	GO:0065007; biological regulation	GO:0030003; cellular cation homeostasis	5.340E-05	9.690E-03	CA2, CA7, DRD2, DRD3, DRD4, HIF1A
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	5.376E-24	5.853E-20	CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	2.465E-22	1.342E-18	CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	6.016E-30	2.707E-28	CA12, CA1, CA3, CA5B, CA2, CA5A, CA4, CA7, CA6, CA9, CA14
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	1.684E-05	3.789E-04	CNR2, CNR1, DRD2, DRD3, DRD4
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	8.225E-05	1.234E-03	RXRA, CA2, NR1H4
09150 Organismal Systems	09156 Nervous system	hsa04728	Dopaminergic synapse	4.805E-04	4.325E-03	DRD2, DRD3, DRD4
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	3.438E-04	3.868E-03	CA2, CA4
09150 Organismal Systems	09152 Endocrine system	hsa04919	Thyroid hormone signaling pathway	8.752E-03	6.564E-02	RXRA, HIF1A
09100 Metabolism	09101 Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	3.772E-02	1.474E-01	AKR1B10
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	7.185E-02	1.474E-01	ALOX5
09160 Human Diseases	09161 Cancers	hsa05211	Renal cell carcinoma	7.631E-02	1.474E-01	HIF1A
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	7.742E-02	1.474E-01	HIF1A

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Emesis	R11	DRD3;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;
C00-D49: Neoplasms	Cutaneous T-cell lymphoma	C84.0, C84.1	RXRA;
NA: NA	Edema	NA	CA2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Drug abuse	F10-F19	DRD3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Male sexual disorders	F52	DRD3;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychotic disorders	F20-F29	DRD3;
K00-K95: Diseases of the digestive system	Gastric motility disorder	K22.4	DRD3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Female sexual dysfunction	F52	DRD3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cocaine addiction	F14.2	DRD3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	DRD3;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases