CMAUP Plant Collective Molecular Activities

Plant Name: Aconitum japonicum

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0008270; zinc ion binding	1.923E-12	4.188E-09	CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR2, NR1H4, RXRA
BP	Unclassified;	GO:0032846; positive regulation of homeostatic process	7.993E-09	1.160E-05	CA2, CA7, CNR1, DRD2, DRD3, HIF1A, NR1H4
BP	GO:0050896; response to stimulus	GO:0001975; response to amphetamine	2.690E-08	3.446E-05	CNR2, DRD2, DRD3, DRD4
MF	GO:0060089; molecular transducer activity	GO:0001591; dopamine neurotransmitter receptor activity, coupled via Gi/Go	9.399E-08	8.528E-05	DRD2, DRD3, DRD4
BP	GO:0009987; cellular process	GO:0007195; adenylate cyclase-inhibiting dopamine receptor signaling pathway	2.011E-07	1.631E-04	DRD2, DRD3, DRD4
BP	GO:0050896; response to stimulus	GO:0034776; response to histamine	2.763E-07	2.074E-04	DRD2, DRD3, DRD4
MF	GO:0005488; binding	GO:0035240; dopamine binding	4.781E-07	3.358E-04	DRD2, DRD3, DRD4
BP	Unclassified;	GO:0032844; regulation of homeostatic process	1.253E-06	6.996E-04	CA2, CA7, CNR1, DRD2, DRD3, HIF1A, NR1H4
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	9.742E-31	2.121E-26	CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0007610; behavior	GO:0048148; behavioral response to cocaine	1.895E-06	1.006E-03	DRD2, DRD3, DRD4
BP	GO:0051179; localization	GO:0050482; arachidonic acid secretion	2.936E-06	1.390E-03	DRD2, DRD3, DRD4
BP	GO:0009987; cellular process	GO:0060160; negative regulation of dopamine receptor signaling pathway	4.435E-06	1.694E-03	DRD2, DRD3
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	4.435E-06	1.694E-03	CA2, CA7
BP	GO:0009987; cellular process	GO:0033602; negative regulation of dopamine secretion	4.435E-06	1.694E-03	CNR1, DRD2
BP	GO:0023052; signaling	GO:0051586; positive regulation of dopamine uptake involved in synaptic transmission	4.435E-06	1.694E-03	DRD2, DRD4
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	4.435E-06	1.694E-03	GPBAR1, NR1H4
MF	GO:0060089; molecular transducer activity	GO:0004949; cannabinoid receptor activity	4.435E-06	1.694E-03	CNR1, CNR2
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	4.435E-06	1.694E-03	GPBAR1, NR1H4
BP	GO:0008152; metabolic process	GO:0042417; dopamine metabolic process	5.410E-06	1.963E-03	DRD2, DRD3, DRD4
BP	GO:0065007; biological regulation	GO:0007194; negative regulation of adenylate cyclase activity	8.164E-06	2.653E-03	DRD2, DRD3, DRD4
BP	GO:0050896; response to stimulus	GO:0043278; response to morphine	8.164E-06	2.653E-03	CNR1, DRD2, DRD3
BP	GO:0009987; cellular process	GO:0038171; cannabinoid signaling pathway	8.864E-06	2.757E-03	CNR1, CNR2
BP	GO:0065007; biological regulation	GO:0098771; inorganic ion homeostasis	9.255E-06	2.838E-03	CA12, CA2, CA7, DRD2, DRD3, DRD4, HIF1A
BP	GO:0009987; cellular process	GO:0050709; negative regulation of protein secretion	1.413E-05	3.894E-03	DRD2, DRD3, DRD4, NR1H4
BP	GO:0040011; locomotion	GO:0090325; regulation of locomotion involved in locomotory behavior	1.476E-05	4.005E-03	DRD2, DRD3
BP	GO:0065007; biological regulation	GO:0045776; negative regulation of blood pressure	1.874E-05	4.691E-03	CNR1, DRD2, DRD3
BP	Unclassified;	GO:0032415; regulation of sodium:proton antiporter activity	2.213E-05	5.071E-03	DRD3, DRD4
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	2.213E-05	5.071E-03	CA1, CA2
BP	GO:0007610; behavior	GO:0008542; visual learning	2.810E-05	5.883E-03	DRD2, DRD3, HIF1A
MF	GO:0140110; transcription regulator activity	GO:0004879; nuclear receptor activity	2.991E-05	6.030E-03	ESR2, NR1H4, RXRA
BP	GO:0008152; metabolic process	GO:0051001; negative regulation of nitric-oxide synthase activity	3.095E-05	6.127E-03	CNR1, CNR2
MF	GO:0060089; molecular transducer activity	GO:0003707; steroid hormone receptor activity	5.234E-05	9.578E-03	ESR2, NR1H4, RXRA
BP	GO:0065007; biological regulation	GO:0030003; cellular cation homeostasis	5.340E-05	9.690E-03	CA2, CA7, DRD2, DRD3, DRD4, HIF1A
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	5.376E-24	5.853E-20	CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	2.465E-22	1.342E-18	CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa00910	Nitrogen metabolism_Homo sapiens_hsa00910	6.016E-30	2.707E-28	CA12; CA1; CA3; CA5B; CA2; CA5A; CA4; CA7; CA6; CA9; CA14
hsa04080	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.684E-05	3.789E-04	CNR2; CNR1; DRD2; DRD3; DRD4
hsa04976	Bile secretion_Homo sapiens_hsa04976	8.225E-05	1.234E-03	RXRA; CA2; NR1H4
hsa04728	Dopaminergic synapse_Homo sapiens_hsa04728	4.805E-04	4.325E-03	DRD2; DRD3; DRD4
hsa04964	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	3.438E-04	3.868E-03	CA2; CA4

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
J00-J99: Diseases of the respiratory system	Rhinitis	J00, J30, J31.0	ALOX5
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	ALOX5; CNR2
L00-L99: Diseases of the skin and subcutaneous tissue	Atopic dermatitis	L00-L99	ALOX5; CNR2
C00-D49: Neoplasms	Solid tumours	C00-D48	HIF1A; CA9
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	DRD2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anorexia	F50.0-F50.1	CNR1
NA: NA	Schizoaffective disorders	NA	DRD2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	DRD2
I00-I99: Diseases of the circulatory system	Thrombosis	I80-I82	ALOX5
NA: NA	Peripheral vasoconstriction	NA	DRD2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Substance dependence	F10-F19	DRD2
A00-B99: Certain infectious and parasitic diseases	Postherpetic neuralgia	B02.2, G44.847, G53.0	CNR1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	DRD2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Advanced stage Parkinson's disease	F02.3, G20	DRD2
E00-E89: Endocrine, nutritional and metabolic diseases	Endocrine disease	E00-E35	CNR1
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Emesis	R11	DRD3; DRD2
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	DRD2
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoporosis	M80-M81, Z79.890	CNR2
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2; CA1
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	CNR1; GPBAR1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Nicotine dependence	F17	CNR1
K00-K95: Diseases of the digestive system	Gastrointestinal problems	K30-K31, Q40-Q41	DRD2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Erectile dysfunction	F52.2, N48.4	DRD4
J00-J99: Diseases of the respiratory system	Asthma	J45	ALOX5; ALOX5; DRD2
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	ALOX5
L00-L99: Diseases of the skin and subcutaneous tissue	Pruritus	L29	ALOX5
L00-L99: Diseases of the skin and subcutaneous tissue	Dermatitis	L20-L30	ALOX5
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	CNR1; CNR1; CNR1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Bipolar disorder	F31, F40-F42	DRD2; DRD2; DRD2; DRD2
NA: NA	Benign prostatic hypertrophy	NA	DRD2
G00-G99: Diseases of the nervous system G00-G99	Migraine headaches	G43	DRD2
C00-D49: Neoplasms	Cutaneous T-cell lymphoma	C84.0, C84.1	RXRA
NA: NA	Edema	NA	CA2
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	CNR1; CNR1; GPBAR1
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	ALOX5
O00-O9A: Pregnancy, childbirth and the puerperium	Postpartum haemorrhage	O72	DRD2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Drug abuse	F10-F19	CNR1; DRD3
A00-B99: Certain infectious and parasitic diseases	Lymphatic filariasis	B74	ALOX5
E00-E89: Endocrine, nutritional and metabolic diseases	Carcinoid syndrome	E34.0	DRD2
C00-D49: Neoplasms	Cancer	C00-C96	HIF1A; CA1; CA9
J00-J99: Diseases of the respiratory system	Bronchitis	J20-J21, J42	DRD2
NA: NA	Malignant phaeochromocytoma	NA	DRD2
NA: NA	Malignant essential hypertension	NA	DRD2
I00-I99: Diseases of the circulatory system	Angina pectoris	I20	DRD2
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	CA1; CA1; DRD2
I00-I99: Diseases of the circulatory system	Cardiotonic	I50	DRD2
I00-I99: Diseases of the circulatory system	Cardiac failure	I50	DRD2
I00-I99: Diseases of the circulatory system	Maintain blood pressure in hypotensive states	I10	DRD2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Male sexual disorders	F52	DRD3
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9
K00-K95: Diseases of the digestive system	Dermal necrosis	K05	DRD2
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Depressive fatigue	R53.82	DRD2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Huntington's disease	F02.2, G10	DRD2
NA: NA	Hyperaemia	NA	DRD2
H00-H59: Diseases of the eye and adnexa	Ophthalmic disease	H00-H59	DRD2
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2; CA4
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4; CA4
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	CNR1; DRD2
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	CNR1
C00-D49: Neoplasms	Lymphoma	C81-C86	HIF1A; CA9
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	CNR1; DRD2; DRD2
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperprolactinemia	E22.1	DRD2
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	ALOX5
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Chemotherapy-induced nausea	R11	CNR1
E00-E89: Endocrine, nutritional and metabolic diseases	Lipid metabolism disorder	E75-E78	CNR1
NA: NA	Corneal vascularity	NA	DRD2
C00-D49: Neoplasms	Ovarian cancer	C56	CNR1
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	ALOX5; DRD2
NA: NA	Itching	NA	DRD2
I00-I99: Diseases of the circulatory system	Ischemia	I99.8	CNR1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Sexual dysfunction	F52	DRD2
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	CA1
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	DRD2
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	CNR1; DRD2; CNR2
NA: NA	Vomiting	NA	DRD2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2; CNR1; DRD2
K00-K95: Diseases of the digestive system	Inflammatory bowel disease	K50, K51	DRD2; CNR2
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	ALOX5
NA: NA	Inflammatory diseases	NA	DRD2
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	ALOX5; DRD2; CNR2
E00-E89: Endocrine, nutritional and metabolic diseases	Acromegaly	E22.0	DRD2
I00-I99: Diseases of the circulatory system	Pulmonary arterial hypertension	I27.0, I27.2	HIF1A
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychotic disorders	F20-F29	CNR1; DRD3; DRD4; DRD2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychosis	F20-F29	DRD2
K00-K95: Diseases of the digestive system	Gastric motility disorder	K22.4	DRD3
A00-B99: Certain infectious and parasitic diseases	Fungal infections	B35-B49	ALOX5
L00-L99: Diseases of the skin and subcutaneous tissue	Fibrosis	L90.5	DRD2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Female sexual dysfunction	F52	DRD3
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	DRD2
S00-T88: Injury, poisoning and certain other consequences of external causes	Allergy	T78.4	ALOX5; DRD2
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	ALOX5
NA: NA	False perceptions	NA	DRD2
J00-J99: Diseases of the respiratory system	Nasal congestion	J34.89	DRD2
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Nausea	R11	DRD2
I00-I99: Diseases of the circulatory system	Hypotension	I95	DRD2
C00-D49: Neoplasms	Renal cancer	C64	CA9
J00-J99: Diseases of the respiratory system	Respiratory disease	J00-J99	ALOX5
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	CNR1; CNR2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cocaine addiction	F14.2	DRD3
C00-D49: Neoplasms	Breast cancer	C50	CA9; DRD2
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Idiopathic thrombocytopenic purpura	D69.3	DRD2
I00-I99: Diseases of the circulatory system	Pulmonary hypertension	I27.0, I27.2	DRD2
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	CNR1; CNR1; CNR1; CNR1; CNR1; CNR1
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	DRD2
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Immune disorder	D80-D89	CNR2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	CNR1; DRD3; DRD4; DRD2; DRD2; DRD2; DRD2

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases