Putative targets based on weak experimental activity

Plant ingredients against the target with activities between 10uM and 50uM


Ingredient ID Target (Gene Symbol) No. of Activity Values Activity Value (nM) Activity Type Activity Reference
NPC100551 CA14 1 49800 Ki PMID: 18579385
NPC100551 ALDH1A1 2 Median: 39810.7
Range: 39810.7 to 39810.7
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC100551 SMN1;SMN2 1 35481.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC100551 KDM4E 1 28183.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC100551 HPGD 2 Median: 29903.3
Range: 28183.8 to 31622.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC115207 PTPN1 1 18690 IC50 PMID: 24224843
NPC161557 PPARD 1 49500 EC50 PMID: 22381047
NPC168829 POLB 1 35481.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC168829 GAA 1 35481.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC168829 MAPT 1 17782.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC178383 TOP2A 1 38600 IC50 PMID: 11754608
NPC230301 DPP4 1 28840 IC50 DOI: 10.1039/C0MD00245C
NPC230301 POLB 1 26300 IC50 PMID: 14640519
NPC264317 POLB 2 Median: 44925
Range: 43600 to 46250
IC50 PMID: 14640519
PMID: 18343122
NPC264317 GLI1 2 Median: 32000
Range: 32000 to 32000
IC50 PMID: 18842418
PMID: 19309080
NPC300020 MAOA 1 31000 Ki PMID: 24559070
NPC33338 CYP2C9 1 15848.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC81010 ESR1 1 16120 EC50 PMID: 23608764
NPC100551 CA6 2 Median: 1165950
Range: 11900 to 2320000
Ki PMID: 18579385
PMID: 21669522
NPC100551 CA4 1 11100 Ki PMID: 18579385
NPC115207 ALOX5 1 13800 IC50 PMID: 17378609
NPC264317 AKR1B1 1 11000 IC50 PMID: 21561086
NPC33338 TSHR 1 12589.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC33338 KDM4E 1 11220.2 Potency PubChem BioAssay data set
CHEMBL1201862
NPC81010 HCAR2 1 14000 Ki PMID: 21167710