CMAUP Plant Collective Molecular Activities

Plant Name: Anemarrhena asphodeloides

Taxonomic Information:

Plant ID: NPO26741
Plant Latin Name: Anemarrhena asphodeloides
Taxonomy Genus: Anemarrhena
Taxonomy Family: Asparagaceae

Plant External Links:

NCBI TaxonomyDB: 59045
Plant-of-the-World-Online: 530140-1

Used in Medicines:

Country/Region:

China; India

Traditional Medicine System:

Indian Folk; TCM; Kampo

Medicinal Functions:

Antianxiety; Antifungal; Antiseptic; Bitter; Diuretic; Expectorant; Febrifuge; Hypoglycaemic; Laxative; Lenitive; Sedative; Tonic

Geographical Distribution:

India; Taiwan; China; Mongolia; South Africa

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Small molecule receptor (family A GPCR)	HCAR2;
Phosphodiesterase 5	PDE5A;
Hydrolase	GAA;
Enzyme_unclassified	BLM; IDO1; AKR1B1; HSD17B10; ALOX15;
Protein Kinase	PIM1; CSNK2A1;
Lyase	CA12; CA1; CA5B; CA5A; CA6;
Nuclear hormone receptor subfamily 1 group C	PPARA; PPARD;
Nuclear hormone receptor subfamily 3 group A	ESR1; ESR2;
Oxidoreductase	MAOB;
Aspartic protease	BACE1;
Toll-like and Il-1 receptors	TLR2;
Transcription Factor	HIF1A;
ATP-binding cassette	ABCB1;
SLC superfamily of solute carriers	SLCO1B3; SLCO1B1;
Unclassified	LMNA; FABP3; FABP5; FABP2; FABP4; MAPT;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2C19; CYP2C9; CYP3A4;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Aspartic protease	BACE1	Beta-secretase 1	P56817	CHEMBL4822
ATP-binding cassette	ABCB1	P-glycoprotein 1	P08183	CHEMBL4302
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
Enzyme_unclassified	IDO1	Indoleamine 2,3-dioxygenase	P14902	CHEMBL4685
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA5B	Carbonic anhydrase VB	Q9Y2D0	CHEMBL3969
Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Nuclear hormone receptor subfamily 1 group C	PPARD	Peroxisome proliferator-activated receptor delta	Q03181	CHEMBL3979
Nuclear hormone receptor subfamily 3 group A	ESR1	Estrogen receptor alpha	P03372	CHEMBL206
Nuclear hormone receptor subfamily 3 group A	ESR2	Estrogen receptor beta	Q92731	CHEMBL242
Oxidoreductase	MAOB	Monoamine oxidase B	P27338	CHEMBL2039
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Phosphodiesterase 5	PDE5A	Phosphodiesterase 5A	O76074	CHEMBL1827
Protein Kinase	PIM1	Serine/threonine-protein kinase PIM1	P11309	CHEMBL2147
Protein Kinase	CSNK2A1	Casein kinase II alpha	P68400	CHEMBL3629
SLC superfamily of solute carriers	SLCO1B3	Solute carrier organic anion transporter family member 1B3	Q9NPD5	CHEMBL1743121
SLC superfamily of solute carriers	SLCO1B1	Solute carrier organic anion transporter family member 1B1	Q9Y6L6	CHEMBL1697668
Small molecule receptor (family A GPCR)	HCAR2	Hydroxycarboxylic acid receptor 2	Q8TDS4	CHEMBL3785
Toll-like and Il-1 receptors	TLR2	Toll-like receptor 2	O60603	CHEMBL4163
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	FABP3	Fatty acid binding protein muscle	P05413	CHEMBL3344
Unclassified	FABP5	Fatty acid binding protein epidermal	Q01469	CHEMBL3674
Unclassified	FABP2	Fatty acid binding protein intestinal	P12104	CHEMBL4879
Unclassified	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	4.988E-11	5.430E-07	CA1, CA12, CA5A, CA5B, CA6
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	6.088E-09	1.894E-05	CA1, CA12, CA5A, CA5B, CA6
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.735E-08	4.198E-05	CA1, CA12, CA5A, CA5B, CA6
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	1.184E-07	1.996E-04	CYP2C19, CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0019433; triglyceride catabolic process	1.250E-07	1.996E-04	FABP2, FABP3, FABP4, FABP5
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	1.293E-06	1.173E-03	CYP2C19, CYP2C9, CYP3A4
MF	GO:0005488; binding	GO:0008270; zinc ion binding	1.549E-06	1.298E-03	BLM, CA1, CA12, CA5A, CA5B, CA6, ESR1, ESR2, PPARA, PPARD
MF	GO:0060089; molecular transducer activity	GO:0038052; RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding	3.377E-06	2.372E-03	ESR1, ESR2
BP	GO:0051179; localization	GO:0015718; monocarboxylic acid transport	4.392E-06	2.813E-03	FABP3, PPARA, PPARD, SLCO1B1, SLCO1B3
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	5.811E-06	3.615E-03	AKR1B1, CYP2C19, CYP2C9, CYP3A4, ESR1, PPARD
BP	GO:0051179; localization	GO:0006869; lipid transport	9.068E-06	5.063E-03	ABCB1, FABP3, PPARA, PPARD, SLCO1B1, SLCO1B3
BP	GO:0008152; metabolic process	GO:0006631; fatty acid metabolic process	1.628E-05	7.751E-03	ALOX15, CYP2C19, CYP2C9, FABP3, PPARA, PPARD
BP	GO:0032501; multicellular organismal process	GO:0001816; cytokine production	1.681E-05	7.789E-03	FABP4, HIF1A, IDO1, TLR2
BP	GO:0009987; cellular process	GO:0030522; intracellular receptor signaling pathway	1.731E-05	7.852E-03	ESR1, ESR2, PIM1, PPARA, PPARD
MF	GO:0005488; binding	GO:0034056; estrogen response element binding	2.022E-05	8.322E-03	ESR1, ESR2
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	2.022E-05	8.322E-03	CYP2C9, CYP3A4
BP	GO:0050896; response to stimulus	GO:0009725; response to hormone	2.308E-05	8.975E-03	AKR1B1, CSNK2A1, ESR1, FABP3, MAOB, PPARA, TLR2, TSHR
BP	GO:0008283; cell proliferation	GO:0042127; regulation of cell proliferation	2.419E-05	9.239E-03	AKR1B1, CSNK2A1, ESR1, FABP3, HIF1A, IDO1, LMNA, PDE5A, PIM1, PPARD, TLR2, TSHR

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	8.618E-11	7.670E-09	CA12, CA1, CA5B, CA5A, CA6
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	2.424E-09	1.079E-07	FABP2, FABP3, FABP4, FABP5, PPARA, PPARD
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	2.033E-07	6.031E-06	CYP2C9, ALOX15, CYP3A4, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	7.031E-06	1.403E-04	CYP2C9, MAOB, CYP3A4, CYP2C19
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	7.882E-06	1.403E-04	SLCO1B1, ABCB1, SLCO1B3, CYP3A4
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	4.781E-05	7.091E-04	CYP2C9, MAOB, ALOX15, CYP2C19
Unclassified	Unclassified	hsa01100	Metabolic pathways	2.677E-04	2.978E-03	CYP2C9, MAOB, GAA, ALOX15, AKR1B1, CYP2C19, CYP3A4, HSD17B10, IDO1
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	1.883E-04	2.394E-03	CYP2C9, ALOX15, CYP2C19
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	4.302E-04	4.254E-03	CYP2C9, CYP3A4, CYP2C19
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	1.328E-03	1.182E-02	GAA, AKR1B1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic complication	E08-E13	AKR1B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic cataract	E10.36, E11.36	AKR1B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	AKR1B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	AKR1B1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Erectile dysfunction	F52.2, N48.4	PDE5A;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Spasm	R25.2	PDE5A;
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	PDE5A; HCAR2;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	HCAR2;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	AKR1B1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	AKR1B1;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	AKR1B1;
NA: NA	Raynaud's disease	NA	PDE5A;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	AKR1B1;
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	PDE5A;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	HCAR2;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	PDE5A;
I00-I99: Diseases of the circulatory system	Angina pectoris	I20	PDE5A;
I00-I99: Diseases of the circulatory system	Arteriosclerosis	I70	HCAR2;
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	PDE5A;
J00-J99: Diseases of the respiratory system	Asthma	J45	PDE5A;
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	HCAR2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	HCAR2;
I00-I99: Diseases of the circulatory system	Acute ischemic stroke	I61-I63	HCAR2;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases