Putative targets based on weak experimental activity

Plant ingredients against the target with activities between 10uM and 50uM


Ingredient ID Target (Gene Symbol) No. of Activity Values Activity Value (nM) Activity Type Activity Reference
NPC107482 ALDH1A1 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC146289 TSHR 2 Median: 39810.7
Range: 39810.7 to 39810.7
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC167400 ALDH1A1 1 18029.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC19174 BACE1 1 33000 IC50 DOI: 10.1007/s00044-012-0353-y
NPC19174 NPSR1 1 31622.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC19174 KMT2A 1 31622.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC19174 HPGD 1 28183.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC19174 MTOR 1 26121.6 Potency PubChem BioAssay data set
CHEMBL1201862
NPC19174 APP 1 19700 IC50 PMID: 23786711
NPC19174 GMNN 1 15848.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC19174 PMP22 1 15101.4 Potency PubChem BioAssay data set
CHEMBL1201862
NPC194856 MAOA 1 25000 IC50 PMID: 15482934
NPC194856 FASN 1 17850 IC50 PMID: 20817450
NPC209970 ALOX15 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC209970 PPARG 1 30000 IC50 DOI: 10.1007/s00044-012-0285-6
NPC209970 TDP1 1 25118.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC209970 HSD17B10 1 25118.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC216630 PPARG 1 30000 IC50 DOI: 10.1007/s00044-012-0285-6
NPC229147 CYP19A1 1 30000 IC50 PMID: 11678652
NPC254847 EPHX2 1 36400 IC50 PMID: 26483136
NPC254847 APEX1 1 35481.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC254847 TP53 2 Median: 31622.8
Range: 31622.8 to 31622.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC254847 PTP4A3 2 Median: 31500
Range: 28000 to 35000
IC50 PMID: 22137788
PMID: 22137788
NPC254847 NPC1 1 20596.2 Potency PubChem BioAssay data set
CHEMBL1201862
NPC306397 SIRT5 1 46600 IC50 PMID: 24900427
NPC306397 SIRT1 7 Median: 73000
Range: 25000 to 149000
IC50 PMID: 19700324
PMID: 23318905
PMID: 24900427
PMID: 25275824
PMID: 25549554
PMID: 26696402
DOI: 10.1039/C1MD00199J
NPC3224 ALDH1A1 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC40209 ALDH1A1 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC40209 TSHR 2 Median: 39810.7
Range: 39810.7 to 39810.7
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC19174 CHRNA7 1 11600 EC50 PMID: 25232969
NPC194856 MMP1 1 11360 IC50 PMID: 22658537
NPC254847 TDP1 2 Median: 15186.05
Range: 12589.3 to 17782.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC254847 CYP2D6 2 Median: 22106.05
Range: 12589.3 to 31622.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC254847 THPO 2 Median: 12589.3
Range: 12589.3 to 12589.3
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC254847 GMNN 1 12589.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC254847 ALDH1A1 2 Median: 13357.35
Range: 12589.3 to 14125.4
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC254847 MAPK1 2 Median: 11904.75
Range: 11220.2 to 12589.3
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC254847 POLB 1 11220.2 Potency PubChem BioAssay data set
CHEMBL1201862
NPC275055 MAOA 1 11460 IC50 PMID: 21405131
NPC29883 CA2 2 Median: 10600
Range: 10600 to 10600
Ki PMID: 18501600
PMID: 18579385