CMAUP Plant Collective Molecular Activities

Plant Name: Anemarrhena asphodeloides

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	4.988E-11	5.430E-07	CA1, CA12, CA5A, CA5B, CA6
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	6.088E-09	1.894E-05	CA1, CA12, CA5A, CA5B, CA6
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.735E-08	4.198E-05	CA1, CA12, CA5A, CA5B, CA6
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	1.184E-07	1.996E-04	CYP2C19, CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0019433; triglyceride catabolic process	1.250E-07	1.996E-04	FABP2, FABP3, FABP4, FABP5
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	1.293E-06	1.173E-03	CYP2C19, CYP2C9, CYP3A4
MF	GO:0005488; binding	GO:0008270; zinc ion binding	1.549E-06	1.298E-03	BLM, CA1, CA12, CA5A, CA5B, CA6, ESR1, ESR2, PPARA, PPARD
MF	GO:0060089; molecular transducer activity	GO:0038052; RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding	3.377E-06	2.372E-03	ESR1, ESR2
BP	GO:0051179; localization	GO:0015718; monocarboxylic acid transport	4.392E-06	2.813E-03	FABP3, PPARA, PPARD, SLCO1B1, SLCO1B3
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	5.811E-06	3.615E-03	AKR1B1, CYP2C19, CYP2C9, CYP3A4, ESR1, PPARD
BP	GO:0051179; localization	GO:0006869; lipid transport	9.068E-06	5.063E-03	ABCB1, FABP3, PPARA, PPARD, SLCO1B1, SLCO1B3
BP	GO:0050896; response to stimulus	GO:1901700; response to oxygen-containing compound	1.371E-05	7.158E-03	AKR1B1, BLM, CSNK2A1, ESR1, FABP3, IDO1, MAOB, PPARA, PPARD, TLR2, TSHR
BP	GO:0008152; metabolic process	GO:0006631; fatty acid metabolic process	1.628E-05	7.751E-03	ALOX15, CYP2C19, CYP2C9, FABP3, PPARA, PPARD
BP	GO:0032501; multicellular organismal process	GO:0001816; cytokine production	1.681E-05	7.789E-03	FABP4, HIF1A, IDO1, TLR2
BP	GO:0009987; cellular process	GO:0030522; intracellular receptor signaling pathway	1.731E-05	7.852E-03	ESR1, ESR2, PIM1, PPARA, PPARD
MF	GO:0005488; binding	GO:0043167; ion binding	1.906E-05	8.322E-03	ABCB1, ALOX15, BLM, CA1, CA12, CA5A, CA5B, CA6, CSNK2A1, CYP2C19, CYP2C9, CYP3A4, ESR1, ESR2, FABP2, FABP3, FABP4, FABP5, IDO1, MAOB, PDE5A, PIM1, PPARA, PPARD
MF	GO:0005488; binding	GO:0034056; estrogen response element binding	2.022E-05	8.322E-03	ESR1, ESR2
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	2.022E-05	8.322E-03	CYP2C9, CYP3A4
BP	GO:0050896; response to stimulus	GO:0009725; response to hormone	2.308E-05	8.975E-03	AKR1B1, CSNK2A1, ESR1, FABP3, MAOB, PPARA, TLR2, TSHR
BP	GO:0008283; cell proliferation	GO:0042127; regulation of cell proliferation	2.419E-05	9.239E-03	AKR1B1, CSNK2A1, ESR1, FABP3, HIF1A, IDO1, LMNA, PDE5A, PIM1, PPARD, TLR2, TSHR

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa00910	Nitrogen metabolism_Homo sapiens_hsa00910	8.618E-11	7.670E-09	CA12; CA1; CA5B; CA5A; CA6
hsa03320	PPAR signaling pathway_Homo sapiens_hsa03320	2.424E-09	1.079E-07	FABP2; FABP3; FABP4; FABP5; PPARA; PPARD
hsa00591	Linoleic acid metabolism_Homo sapiens_hsa00591	2.033E-07	6.031E-06	CYP2C9; ALOX15; CYP3A4; CYP2C19
hsa00982	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	7.031E-06	1.403E-04	CYP2C9; MAOB; CYP3A4; CYP2C19
hsa04976	Bile secretion_Homo sapiens_hsa04976	7.882E-06	1.403E-04	SLCO1B1; ABCB1; SLCO1B3; CYP3A4
hsa04726	Serotonergic synapse_Homo sapiens_hsa04726	4.781E-05	7.091E-04	CYP2C9; MAOB; ALOX15; CYP2C19
hsa01100	Metabolic pathways_Homo sapiens_hsa01100	2.677E-04	2.978E-03	CYP2C9; MAOB; GAA; ALOX15; AKR1B1; CYP2C19; CYP3A4; HSD17B10; IDO1
hsa00590	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.883E-04	2.394E-03	CYP2C9; ALOX15; CYP2C19
hsa05204	Chemical carcinogenesis_Homo sapiens_hsa05204	4.302E-04	4.254E-03	CYP2C9; CYP3A4; CYP2C19
hsa05010	Alzheimer's disease_Homo sapiens_hsa05010	3.391E-03	2.515E-02	BACE1; MAPT; HSD17B10
hsa00380	Tryptophan metabolism_Homo sapiens_hsa00380	2.354E-03	1.904E-02	MAOB; IDO1
hsa05205	Proteoglycans in cancer_Homo sapiens_hsa05205	5.749E-03	3.195E-02	HIF1A; ESR1; TLR2
hsa04024	cAMP signaling pathway_Homo sapiens_hsa04024	5.441E-03	3.195E-02	HCAR2; PPARA; TSHR
hsa05221	Acute myeloid leukemia_Homo sapiens_hsa05221	4.724E-03	3.003E-02	PIM1; PPARD
hsa04923	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	4.564E-03	3.003E-02	FABP4; TSHR
hsa00052	Galactose metabolism_Homo sapiens_hsa00052	1.328E-03	1.182E-02	GAA; AKR1B1
hsa04917	Prolactin signaling pathway_Homo sapiens_hsa04917	7.439E-03	3.579E-02	ESR1; ESR2
hsa00830	Retinol metabolism_Homo sapiens_hsa00830	6.102E-03	3.195E-02	CYP2C9; CYP3A4
hsa00980	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	7.640E-03	3.579E-02	CYP2C9; CYP3A4

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
C00-D49: Neoplasms	Pancreatic cancer	C25	TLR2
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ESR1
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	MAOB; MAOB
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	IDO1; MAOB
G00-G99: Diseases of the nervous system G00-G99	Multiple scierosis	G35	ESR1; ESR1
NA: NA	Motor symptoms	NA	MAOB
I00-I99: Diseases of the circulatory system	Moderate to severe hypertension	I10-I16	MAOB
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	CYP3A4; MAOB
Z00-Z99: Factors influencing health status and contact with health services	Oral contraceptive	Z30	ESR1
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAOB; MAPT
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	ESR1
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	ABCB1
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	PPARD; PPARD; MAOB
K00-K95: Diseases of the digestive system	Non-alcoholic fatty liver disease	K76.0	PPARD
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic complication	E08-E13	AKR1B1
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic cataract	E10.36, E11.36	AKR1B1
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	AKR1B1
NA: NA	Gonorrheal vaginitis	NA	ESR1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	MAOB; MAPT
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	AKR1B1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Dementia	F01-F07	MAOB
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Erectile dysfunction	F52.2, N48.4	PDE5A; PDE5A
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	TLR2
A00-B99: Certain infectious and parasitic diseases	Trematode infection	B66.9	ESR1
NA: NA	Postmenopausal disorder	NA	ESR1
C00-D49: Neoplasms	Hormone refractory prostate cancer	C61	ESR1
C00-D49: Neoplasms	Cancer	C00-C96	ABCB1; HIF1A; CA1; IDO1; ESR1; ESR1; TLR2; PIM1; CSNK2A1
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Spasm	R25.2	PDE5A
E00-E89: Endocrine, nutritional and metabolic diseases	Estrogen deficiency	E28.39	ESR1
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	PDE5A; HCAR2
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	PPARD; ESR1; HCAR2
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	CA1; CA1; AKR1B1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	AKR1B1
N00-N99: Diseases of the genitourinary system	Irregularities	N92.6	ESR1
C00-D49: Neoplasms	Brain cancer	C71, D33	ESR1
C00-D49: Neoplasms	Breast cancer	C50	ESR1; ESR1
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	AKR1B1
NA: NA	Dyslipidemia	NA	PPARD
E00-E89: Endocrine, nutritional and metabolic diseases	Dyslipidaemias	E78	PPARD; PPARD
N00-N99: Diseases of the genitourinary system	Dyspareunia	N94.1	ESR1
N00-N99: Diseases of the genitourinary system	Dysmenorrhea	N94.4-N94.6	ESR1
E00-E89: Endocrine, nutritional and metabolic diseases	Hormone deficiency	E00-E90	ESR1; ESR1
S00-T88: Injury, poisoning and certain other consequences of external causes	Radiation sickness	T66	TLR2
NA: NA	Raynaud's disease	NA	PDE5A; PDE5A
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	PPARD; MAOB; MAPT
C00-D49: Neoplasms	Advanced prostate cancer	C61	ESR1
I00-I99: Diseases of the circulatory system	Pulmonary arterial hypertension	I27.0, I27.2	HIF1A
Z00-Z99: Factors influencing health status and contact with health services	Hormone replacement therapy	Z79.890	ESR1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	AKR1B1
H00-H59: Diseases of the eye and adnexa	Eye disorders	H00-H59	ESR1
C00-D49: Neoplasms	Adrenocortical carcinoma	C74.0	ABCB1; ESR1
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	PDE5A; PDE5A
C00-D49: Neoplasms	Prostate cancer	C61	ESR1; TLR2
N00-N99: Diseases of the genitourinary system	Vagina disease	N76.0	ESR1
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA1
L00-L99: Diseases of the skin and subcutaneous tissue	Acne vulgaris	L70.0	ESR1
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAOB; MAPT
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR
E00-E89: Endocrine, nutritional and metabolic diseases	Type 1 diabetes	E10	PPARD
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	PPARD; HCAR2
E00-E89: Endocrine, nutritional and metabolic diseases	Hypogonadism	E23.0, E28.3, E29.1	ESR1
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	CA1
C00-D49: Neoplasms	Colorectal cancer	C18-C21	PDE5A
I00-I99: Diseases of the circulatory system	Angina pectoris	I20	PDE5A
C00-D49: Neoplasms	Lymphoma	C81-C86	HIF1A
Z00-Z99: Factors influencing health status and contact with health services	Contraception	Z30	ESR1
C00-D49: Neoplasms	Leukemia	C90-C95	ESR1
C00-D49: Neoplasms	Carcinoma	D00-D09	ESR1
Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities	Osteopetrosis	Q78.2	ESR1
I00-I99: Diseases of the circulatory system	Arteriosclerosis	I70	HCAR2
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	ESR1; TLR2
M00-M99: Diseases of the musculoskeletal system and connective tissue	Atrophy	M62.571	ESR1
N00-N99: Diseases of the genitourinary system	Atrophic vaginitis	N95.2	ESR1
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	ABCB1; CYP2C9; MAOB
C00-D49: Neoplasms	Melanoma	C43	TLR2
NA: NA	Menopausal disorder	NA	ESR1
N00-N99: Diseases of the genitourinary system	Female infertility	N97.0	ESR1; ESR1
N00-N99: Diseases of the genitourinary system	Female infertility due to anovulation	N97.0	ESR1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Female sexual dysfunction	F52	ESR1
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	PDE5A
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthralgia	M25.5	ESR1
J00-J99: Diseases of the respiratory system	Asthma	J45	PDE5A
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	PPARD; HCAR2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive episode without melancholia	F30-F39	MAOB
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	HCAR2; MAOB
E00-E89: Endocrine, nutritional and metabolic diseases	Female hypogonadism	E23, E28	ESR1
N00-N99: Diseases of the genitourinary system	Post-menopausal vaginal atrophy	N95.2	ESR1
E00-E89: Endocrine, nutritional and metabolic diseases	Pompe's disease	E74.02	GAA
C00-D49: Neoplasms	Solid tumours	C00-D48	ABCB1; HIF1A; TLR2
I00-I99: Diseases of the circulatory system	Acute ischemic stroke	I61-I63	HCAR2
C00-D49: Neoplasms	Ovarian cancer	C56	ABCB1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoporosis	M80-M81, Z79.890	ESR1
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR
N00-N99: Diseases of the genitourinary system	Infertility	N97.0	ESR1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Idiopathic parkinson's disease	F02.3, G20	MAOB
N00-N99: Diseases of the genitourinary system	Menorrhagia	N92.0	ESR1
N00-N99: Diseases of the genitourinary system	Menopause symptoms	N95.0	ESR1; ESR1
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	PPARD

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases