CMAUP Plant Collective Molecular Activities

Plant Name: Aristolochia debilis

Taxonomic Information:

Plant ID: NPO24916
Plant Latin Name: Aristolochia debilis
Taxonomy Genus: Aristolochia
Taxonomy Family: Aristolochiaceae

Plant External Links:

NCBI TaxonomyDB: 158541
Plant-of-the-World-Online: 92883-1

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Medicinal Functions:

Alterative; Anodyne; Antibacterial; Antifungal; Antiinflammatory; Antitussive; Carminative; Cytotoxic; Diuretic; Expectorant; Hypotensive; Stomachic; Tonic

Geographical Distribution:

Japan; China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Transient receptor potential channel	TRPA1;
Protein Kinase	MAPK1; CDK2;
Lyase	CA2; CA3; CA7; CA5A; CA4; CA6; CA12; CA1; CA9; CA5B; CA14;
Nuclear hormone receptor subfamily 3 group A	ESR2;
Oxidoreductase	PTGS1;
Enzyme_unclassified	USP2;
Unclassified	MAPT; HTT;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	USP2	Ubiquitin carboxyl-terminal hydrolase 2	O75604	CHEMBL1293227
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA3	Carbonic anhydrase III	P07451	CHEMBL2885
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA5B	Carbonic anhydrase VB	Q9Y2D0	CHEMBL3969
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Nuclear hormone receptor subfamily 3 group A	ESR2	Estrogen receptor beta	Q92731	CHEMBL242
Oxidoreductase	PTGS1	Cyclooxygenase-1	P23219	CHEMBL221
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Protein Kinase	CDK2	Cyclin-dependent kinase 2	P24941	CHEMBL301
Transient receptor potential channel	TRPA1	Transient receptor potential cation channel subfamily A member 1	O75762	CHEMBL6007
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	HTT	Huntingtin	P42858	CHEMBL5514

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0008270; zinc ion binding	3.168E-10	6.272E-07	CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR2
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	2.754E-31	5.997E-27	CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	3.712E-06	4.255E-03	CA2, CA7
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.524E-24	1.659E-20	CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	8.148E-23	4.435E-19	CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	1.852E-05	1.833E-02	CA1, CA2
CC	GO:0043226; organelle	GO:0015030; Cajal body	2.733E-05	2.588E-02	CDK2, SMN1, SMN2
BP	GO:0050896; response to stimulus	GO:0006979; response to oxidative stress	3.522E-05	3.195E-02	CA3, CDK2, MAPK1, PTGS1, TRPA1
BP	GO:0051179; localization	GO:2001225; regulation of chloride transport	5.542E-05	4.827E-02	CA2, CA7

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.701E-30	1.888E-28	CA12, CA1, CA3, CA5B, CA2, CA5A, CA4, CA7, CA6, CA9, CA14
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2.882E-04	1.599E-02	CA2, CA4
09150 Organismal Systems	09152 Endocrine system	hsa04917	Prolactin signaling pathway	2.818E-03	7.820E-02	MAPK1, ESR2
09160 Human Diseases	09161 Cancers	hsa05215	Prostate cancer	4.269E-03	8.330E-02	CDK2, MAPK1
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	2.741E-03	7.820E-02	CA2, CYP3A4
09150 Organismal Systems	09152 Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	5.150E-03	8.330E-02	CDK2, MAPK1
09150 Organismal Systems	09152 Endocrine system	hsa04915	Estrogen signaling pathway	5.253E-03	8.330E-02	MAPK1, ESR2
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	6.673E-03	8.876E-02	MAPK1, PTGS1
09150 Organismal Systems	09151 Immune system	hsa04611	Platelet activation	7.871E-03	8.876E-02	MAPK1, PTGS1
09140 Cellular Processes	09143 Cell growth and death	hsa04114	Oocyte meiosis	7.996E-03	8.876E-02	CDK2, MAPK1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MAPK1;
C00-D49: Neoplasms	Cancer	C00-C96	MAPK1;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
C00-D49: Neoplasms	Solid tumours	C00-D48	MAPK1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
NA: NA	Edema	NA	CA2;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases