CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0008270; zinc ion binding	3.168E-10	6.272E-07	CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR2
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	2.754E-31	5.997E-27	CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	3.712E-06	4.255E-03	CA2, CA7
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.524E-24	1.659E-20	CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	8.148E-23	4.435E-19	CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa00910	Nitrogen metabolism_Homo sapiens_hsa00910	1.701E-30	1.888E-28	CA12; CA1; CA3; CA5B; CA2; CA5A; CA4; CA7; CA6; CA9; CA14
hsa04964	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	2.882E-04	1.599E-02	CA2; CA4

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	PTGS1
C00-D49: Neoplasms	Breast cancer	C50	CA9
N00-N99: Diseases of the genitourinary system	Dysmenorrhea	N94.4-N94.6	PTGS1
NA: NA	Miosis during ocular surgery	NA	PTGS1
S00-T88: Injury, poisoning and certain other consequences of external causes	Postoperative inflammation	T81	PTGS1
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	CA1; CA1
J00-J99: Diseases of the respiratory system	Throat irritation	J39.2	TRPA1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	MAPT
L00-L99: Diseases of the skin and subcutaneous tissue	Acne vulgaris	L70.0	PTGS1
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAPT
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	CDK2
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	CYP3A4
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	CA1
C00-D49: Neoplasms	Renal cancer	C64	CA9
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MAPK1
C00-D49: Neoplasms	Cancer	C00-C96	CA1; CA9; MAPK1; CDK2
C00-D49: Neoplasms	Acute lymphoblastic leukemia	C91.0	CDK2
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	PTGS1
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	PTGS1
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAPT
G00-G99: Diseases of the nervous system G00-G99	Spinal muscular atrophy	G00-G99	SMN1;SMN2
C00-D49: Neoplasms	Solid tumours	C00-D48	CA9; MAPK1; CDK2
C00-D49: Neoplasms	Thymoma	C37, D15.0	CDK2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	PTGS1
K00-K95: Diseases of the digestive system	Inflammatory bowel disease	K50, K51	PTGS1
K00-K95: Diseases of the digestive system	Ulcerative colitis	K51	PTGS1
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9
NA: NA	Edema	NA	CA2
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2
C00-D49: Neoplasms	Colorectal cancer	C18-C21	PTGS1
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2; CA1
NA: NA	Rheumatold arthritis	NA	PTGS1
E00-E89: Endocrine, nutritional and metabolic diseases	Dietary shortage	E40-E46	PTGS1
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2; CA4
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	PTGS1; TRPA1
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4; CA4
L00-L99: Diseases of the skin and subcutaneous tissue	Dermatitis	L20-L30	PTGS1

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Aristolochia debilis

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Human Protein Targets

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases