CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	GPR35;
Peptide receptor (family A GPCR)	NPSR1;
Enzyme_unclassified	RECQL; TDP1; ALOX12; AKR1B1; HSD17B2; HSD17B10; HPGD; NOX4; APEX1; POLB;
Protein Kinase	TEK; INSR; MET; AXL; KDR; FLT3; CDK1; EGFR; PIM1; SRC; IGF1R; AURKB; CSNK2A1; NUAK1;
Lyase	CA12; CA7;
Oxidoreductase	TYR;
Transcription Factor	AHR;
SLC superfamily of solute carriers	SLC22A6;
Unclassified	SMAD3; HSPA1A;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2; CYP1B1; CYP1A1;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Enzyme_unclassified	HSD17B2	Estradiol 17-beta-dehydrogenase 2	P37059	CHEMBL2789
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	HPGD	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428	CHEMBL1293255
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Enzyme_unclassified	APEX1	DNA-(apurinic or apyrimidinic site) lyase	P27695	CHEMBL5619

Showing 1 to 10 of 36 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0043066; negative regulation of apoptotic process	1.574E-10	1.359E-07	AKR1B1, ALOX12, AURKB, AXL, CDK1, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, PIM1, SMAD3, SRC, TEK
BP	GO:0009987; cellular process	GO:0051897; positive regulation of protein kinase B signaling	1.121E-08	4.354E-06	AXL, EGFR, INSR, MET, NOX4, SRC, TEK
BP	GO:0008152; metabolic process	GO:0038083; peptidyl-tyrosine autophosphorylation	2.441E-08	8.305E-06	EGFR, IGF1R, INSR, KDR, SRC
BP	GO:0009987; cellular process	GO:0070301; cellular response to hydrogen peroxide	9.291E-08	2.273E-05	AKR1B1, APEX1, AXL, CDK1, CYP1B1
BP	GO:0032502; developmental process	GO:0031100; animal organ regeneration	2.828E-07	6.051E-05	AXL, CDK1, CSNK2A1, EGFR, FLT3
BP	GO:0008152; metabolic process	GO:0055114; oxidation-reduction process	4.252E-07	8.818E-05	AKR1B1, ALOX12, APEX1, CYP1A1, CYP1A2, CYP1B1, HPGD, HSD17B10, HSD17B2, NOX4, TYR
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	7.070E-07	1.400E-04	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0045740; positive regulation of DNA replication	3.238E-06	5.424E-04	CDK1, EGFR, IGF1R, INSR
BP	GO:0009987; cellular process	GO:0006286; base-excision repair, base-free sugar-phosphate removal	3.377E-06	5.529E-04	APEX1, POLB
BP	GO:0032502; developmental process	GO:0007568; aging	3.955E-06	6.286E-04	APEX1, AURKB, CDK1, CYP1A1, NOX4, POLB

Showing 1 to 10 of 39 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3.499E-06	6.649E-05	CYP1A2, HSD17B2, CYP1A1, CYP1B1
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	5.055E-05	5.239E-04	CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3.055E-04	1.935E-03	CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	4.212E-04	2.452E-03	CA12, CA7
09120 Genetic Information Processing	09124 Replication and repair	hsa03410	Base excision repair	1.606E-03	7.323E-03	POLB, APEX1
09130 Environmental Information Processing	09132 Signal transduction	hsa04015	Rap1 signaling pathway	8.479E-08	3.222E-06	SRC, INSR, KDR, TEK, MET, EGFR, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04014	Ras signaling pathway	2.932E-06	6.649E-05	INSR, KDR, TEK, MET, EGFR, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04151	PI3K-Akt signaling pathway	2.974E-05	3.791E-04	INSR, KDR, TEK, MET, EGFR, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	3.443E-05	3.924E-04	INSR, TEK, EGFR, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04068	FoxO signaling pathway	9.334E-05	8.868E-04	SMAD3, INSR, EGFR, IGF1R

Showing 1 to 10 of 26 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Cryptosporidium infection	A07.2	EGFR;
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
C00-D49: Neoplasms	Acute lymphoblastic leukemia	C91.0	FLT3;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	AURKB; FLT3;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	AURKB; SRC;
C00-D49: Neoplasms	Metastatic breast cancer	C50	KDR;
C00-D49: Neoplasms	Glioma	C71	KDR; EGFR;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	KDR; EGFR; AKR1B1;
C00-D49: Neoplasms	Advanced cancers	C00-C96	EGFR;
C00-D49: Neoplasms	Advanced renal cell carcinoma	C64	KDR;

Showing 1 to 10 of 114 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Gentiana manshurica

Taxonomic Information:

Plant External Links:

Used in Medicines:

Country/Region:

Traditional Medicine System:

Medicinal Functions:

Geographical Distribution:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities