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Plant Name: Gentiana manshurica




Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target
Target Class
Target Proteins
Small molecule receptor (family A GPCR)
GPR35; DRD4;
Peptide receptor (family A GPCR)
NPSR1; CXCR1;
Enzyme_unclassified
RECQL; PLA2G1B; TDP1; BLM; CTDSP1; PIK3R1; GLO1; HPGD; MPO; HSD17B1; AKR1B1; HSD17B2; HSD17B10; ALOX15; ALOX12; NOX4; USP2; PYGL; APEX1; POLB;
Protein Phosphatase
DUSP3;
Hydrolase
GAA;
Protein Kinase
NEK6; AKT1; MET; CAMK2B; GSK3B; CSNK2A1; DAPK1; AXL; NEK2; FLT3; SRC; IGF1R; PTK2; BRAF; AURKB; AURKA; FLT4; EPHB4; MAP3K8; TEK; PDGFRB; INSR; PLK4; CDK1; EGFR; ERBB2; PIM1; NUAK1; ALK; KDR; PLK1; PKN1;
Lyase
CA5A; CA3; CA14; CA7; CA12; CA9; CA13; CA4; CA6; CA2; CA1;
Nuclear hormone receptor subfamily 3 group C
AR;
Nuclear hormone receptor subfamily 3 group B
ESRRA;
Lysine demethylase
KDM4E;
Oxidoreductase
MAOA; ALOX5; TYR; XDH;
Metallo protease
MMP13; MMP3; MMP2; MMP9;
Aspartic protease
BACE1;
Transcription Factor
AHR; STAT6; HIF1A; NFKB1; TP53;
ATP-binding cassette
ABCC1; ABCG2;
SLC superfamily of solute carriers
SLC22A6;
Unclassified
SMAD3; LMNA; HBB; HSPA1A;


List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme
Cytochrome P450 Enzymes: CYP1A2; CYP19A1; CYP2C19; CYP2C9; CYP2C8; CYP3A4; CYP1B1; CYP1A1;

Detailed Information of Human Protein Targets

Protein ClassGene IDProtein NameUniprot IDTarget ChEMBL ID
Aspartic protease BACE1 Beta-secretase 1 P56817 CHEMBL4822
ATP-binding cassette ABCC1 Multidrug resistance-associated protein 1 P33527 CHEMBL3004
ATP-binding cassette ABCG2 ATP-binding cassette sub-family G member 2 Q9UNQ0 CHEMBL5393
Cytochrome P450 family 1 CYP1A2 Cytochrome P450 1A2 P05177 CHEMBL3356
Cytochrome P450 family 1 CYP1B1 Cytochrome P450 1B1 Q16678 CHEMBL4878
Cytochrome P450 family 1 CYP1A1 Cytochrome P450 1A1 P04798 CHEMBL2231
Cytochrome P450 family 19 CYP19A1 Cytochrome P450 19A1 P11511 CHEMBL1978
Cytochrome P450 family 2 CYP2C19 Cytochrome P450 2C19 P33261 CHEMBL3622
Cytochrome P450 family 2 CYP2C9 Cytochrome P450 2C9 P11712 CHEMBL3397
Cytochrome P450 family 2 CYP2C8 Cytochrome P450 2C8 P10632 CHEMBL3721
Showing 1 to 10 of 101 entries
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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)


Detailed Information of Enriched Gene Ontolgy
GO TypeGO CategoryEnriched GO Termsp-ValueAdjusted p-ValueEnriched Genes
BP GO:0008152; metabolic process GO:0097267; omega-hydroxylase P450 pathway 3.630E-12 8.587E-10 CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9
BP GO:0009987; cellular process GO:0051897; positive regulation of protein kinase B signaling 4.307E-10 6.211E-08 AXL, EGFR, ERBB2, INSR, MET, NOX4, PDGFRB, PIK3R1, PTK2, SRC, TEK
BP GO:0008152; metabolic process GO:0019373; epoxygenase P450 pathway 8.955E-10 1.196E-07 CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9
BP GO:0050896; response to stimulus GO:0042738; exogenous drug catabolic process 2.721E-09 3.385E-07 CYP1A2, CYP2C19, CYP2C8, CYP2C9, CYP3A4
BP GO:0008152; metabolic process GO:0016098; monoterpenoid metabolic process 1.048E-08 1.170E-06 CYP1A2, CYP2C19, CYP2C9, CYP3A4
BP GO:0008152; metabolic process GO:0038083; peptidyl-tyrosine autophosphorylation 1.588E-07 1.411E-05 EGFR, IGF1R, INSR, KDR, PTK2, SRC
BP GO:0008152; metabolic process GO:0070989; oxidative demethylation 3.375E-07 2.905E-05 CYP1A2, CYP2C8, CYP2C9, CYP3A4
BP GO:0032502; developmental process GO:0007568; aging 3.657E-07 3.123E-05 AKT1, APEX1, AURKB, CDK1, CYP1A1, MPO, NOX4, PDGFRB, POLB, TP53
BP GO:0008152; metabolic process GO:0043552; positive regulation of phosphatidylinositol 3-kinase activity 4.544E-07 3.762E-05 FLT3, PDGFRB, PTK2, SRC, TEK
BP GO:0008152; metabolic process GO:0006691; leukotriene metabolic process 5.395E-07 4.400E-05 ABCC1, ALOX12, ALOX15, ALOX5, PLA2G1B
Showing 1 to 10 of 112 entries
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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways
Pathway IDPathway Namep-ValueAdjusted p-ValueEnriched Genes
hsa00052 Galactose metabolism_Homo sapiens_hsa00052 1.002E-02 1.951E-02 GAA; AKR1B1
hsa00140 Steroid hormone biosynthesis_Homo sapiens_hsa00140 1.652E-08 1.455E-07 HSD17B1; CYP1A2; HSD17B2; CYP1A1; CYP1B1; CYP3A4; CYP19A1
hsa00232 Caffeine metabolism_Homo sapiens_hsa00232 2.500E-04 7.227E-04 CYP1A2; XDH
hsa00350 Tyrosine metabolism_Homo sapiens_hsa00350 1.348E-02 2.519E-02 MAOA; TYR
hsa00380 Tryptophan metabolism_Homo sapiens_hsa00380 4.869E-05 1.633E-04 MAOA; CYP1A2; CYP1A1; CYP1B1
hsa00590 Arachidonic acid metabolism_Homo sapiens_hsa00590 2.658E-08 2.049E-07 CYP2C9; CYP2C8; PLA2G1B; ALOX5; ALOX15; ALOX12; CYP2C19
hsa00591 Linoleic acid metabolism_Homo sapiens_hsa00591 9.664E-11 2.235E-09 CYP2C9; CYP2C8; PLA2G1B; CYP1A2; ALOX15; CYP3A4; CYP2C19
hsa00830 Retinol metabolism_Homo sapiens_hsa00830 1.931E-05 7.600E-05 CYP2C9; CYP2C8; CYP1A2; CYP1A1; CYP3A4
hsa00910 Nitrogen metabolism_Homo sapiens_hsa00910 3.750E-22 6.938E-20 CA12; CA1; CA3; CA2; CA5A; CA4; CA7; CA6; CA9; CA14; CA13
hsa00980 Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 3.401E-05 1.187E-04 CYP2C9; CYP1A2; CYP1A1; CYP1B1; CYP3A4
Showing 1 to 10 of 113 entries
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Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases
ICD10 Disease CategoryDisease NameICD10 CodeLinked Targets
A00-B99: Certain infectious and parasitic diseases HCV infection B17.1, B18.2 MMP3
A00-B99: Certain infectious and parasitic diseases Cryptosporidium infection A07.2 EGFR
A00-B99: Certain infectious and parasitic diseases Visceral leishmaniasis B55.0 PLA2G1B
A00-B99: Certain infectious and parasitic diseases Bacterial infections A00-B99 CYP2C9
A00-B99: Certain infectious and parasitic diseases Infections disease A00-B99 MPO
A00-B99: Certain infectious and parasitic diseases Leishmaniasis B55.0 PLA2G1B
A00-B99: Certain infectious and parasitic diseases Lymphatic filariasis B74 ALOX5
A00-B99: Certain infectious and parasitic diseases Fungal infections B35-B49 ALOX5
A00-B99: Certain infectious and parasitic diseases Human immunodeficiency virus infection B20-B26 FLT3
C00-D49: Neoplasms Acute lymphoblastic leukemia C91.0 FLT3
Showing 1 to 10 of 215 entries
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Data Section
Select to Download
1. General Info & Plant Usage & Geographical Distribution  
2. Human Target Proteins  
3. Target Gene Ontology  
4. Target KEGG Pathway  
5. Related Human Diseases  
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The CMAUP database is developed by the Bioinformatics & Drug Design group (BIDD), which is based in the Department of Pharmacy, National University of Singapore, Singapore.

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