Plant Name: Paeonia rockii
Taxonomic Information:
Plant ID: NPO15265
Plant Latin Name: Paeonia rockii
Taxonomy Genus: Paeonia
Taxonomy Family: Paeoniaceae
Plant External Links:
NCBI TaxonomyDB:
62886
Plant-of-the-World-Online:
1005939-1
Used in Medicines:
Unknown.
Geographical Distribution:
China
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| GPBAR1; | |
| TSHR; | |
| PTPN1; PTPN2; CDC25B; | |
| PLA2G1B; ALDH1A1; AKR1B10; POLB; | |
| GAA; | |
| MAPK1; | |
| NR1H4; | |
| RELA; NFKB1; | |
| SLCO1B1; SLCO1B3; | |
| MAPT; HTT; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: | CYP3A4; |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Enzyme_unclassified | PLA2G1B | Phospholipase A2 group 1B | P04054 | CHEMBL4426 |
| Enzyme_unclassified | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P00352 | CHEMBL3577 |
| Enzyme_unclassified | AKR1B10 | Aldo-keto reductase family 1 member B10 | O60218 | CHEMBL5983 |
| Enzyme_unclassified | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Hydrolase | GAA | Lysosomal alpha-glucosidase | P10253 | CHEMBL2608 |
| Nuclear hormone receptor subfamily 1 group H | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
| Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
| Protein Kinase | MAPK1 | MAP kinase ERK2 | P28482 | CHEMBL4040 |
| Protein Phosphatase | PTPN1 | Protein-tyrosine phosphatase 1B | P18031 | CHEMBL335 |
| Protein Phosphatase | PTPN2 | T-cell protein-tyrosine phosphatase | P17706 | CHEMBL3807 |
| Protein Phosphatase | CDC25B | Dual specificity phosphatase Cdc25B | P30305 | CHEMBL4804 |
| SLC superfamily of solute carriers | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | Q9Y6L6 | CHEMBL1697668 |
| SLC superfamily of solute carriers | SLCO1B3 | Solute carrier organic anion transporter family member 1B3 | Q9NPD5 | CHEMBL1743121 |
| Small molecule receptor (family A GPCR) | GPBAR1 | G-protein coupled bile acid receptor 1 | Q8TDU6 | CHEMBL5409 |
| Transcription Factor | RELA | Nuclear factor NF-kappa-B p65 subunit | Q04206 | CHEMBL5533 |
| Transcription Factor | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | P19838 | CHEMBL3251 |
| Unclassified | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
| Unclassified | HTT | Huntingtin | P42858 | CHEMBL5514 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0009987; cellular process | GO:0038183; bile acid signaling pathway | 2.748E-06 | 7.794E-03 | GPBAR1, NR1H4 |
| BP | GO:0051179; localization | GO:0015721; bile acid and bile salt transport | 3.221E-06 | 7.794E-03 | NR1H4, SLCO1B1, SLCO1B3 |
| BP | GO:0050896; response to stimulus | GO:0046627; negative regulation of insulin receptor signaling pathway | 3.221E-06 | 7.794E-03 | PTPN1, PTPN2, RELA |
| MF | GO:0060089; molecular transducer activity | GO:0038181; bile acid receptor activity | 2.748E-06 | 7.794E-03 | GPBAR1, NR1H4 |
| BP | GO:0009987; cellular process | GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway | 5.494E-06 | 9.969E-03 | PTPN1, PTPN2 |
| MF | GO:0003824; catalytic activity | GO:0001758; retinal dehydrogenase activity | 1.919E-05 | 1.672E-02 | AKR1B10, ALDH1A1 |
| CC | GO:0032991; macromolecular complex | GO:0033256; I-kappaB/NF-kappaB complex | 1.919E-05 | 1.672E-02 | NFKB1, RELA |
| MF | GO:0005488; binding | GO:0019900; kinase binding | 2.884E-05 | 2.285E-02 | CDC25B, HTT, MAPK1, PTPN1, PTPN2, RELA |
| MF | GO:0005488; binding | GO:0032052; bile acid binding | 3.286E-05 | 2.308E-02 | NR1H4, PLA2G1B |
| MF | GO:0005488; binding | GO:0000980; RNA polymerase II distal enhancer sequence-specific DNA binding | 4.610E-05 | 2.713E-02 | NFKB1, NR1H4, RELA |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 5.428E-07 | 7.219E-05 | SLCO1B1, SLCO1B3, NR1H4, CYP3A4 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04010 | MAPK signaling pathway | 3.255E-06 | 2.165E-04 | MAPK1, MAPT, RELA, NFKB1, CDC25B |
| 09160 Human Diseases | 09161 Cancers | hsa05221 | Acute myeloid leukemia | 2.059E-05 | 4.804E-04 | MAPK1, RELA, NFKB1 |
| 09160 Human Diseases | 09161 Cancers | hsa05212 | Pancreatic cancer | 3.203E-05 | 4.804E-04 | MAPK1, RELA, NFKB1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04024 | cAMP signaling pathway | 3.279E-05 | 4.804E-04 | MAPK1, RELA, NFKB1, TSHR |
| 09160 Human Diseases | 09161 Cancers | hsa05203 | Viral carcinogenesis | 3.682E-05 | 4.804E-04 | POLB, MAPK1, RELA, NFKB1 |
| 09150 Organismal Systems | 09151 Immune system | hsa04621 | NOD-like receptor signaling pathway | 2.059E-05 | 4.804E-04 | MAPK1, RELA, NFKB1 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04917 | Prolactin signaling pathway | 4.159E-05 | 4.804E-04 | MAPK1, RELA, NFKB1 |
| 09150 Organismal Systems | 09151 Immune system | hsa04662 | B cell receptor signaling pathway | 4.335E-05 | 4.804E-04 | MAPK1, RELA, NFKB1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05131 | Shigellosis | 3.059E-05 | 4.804E-04 | MAPK1, RELA, NFKB1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04014 | Ras signaling pathway | 5.479E-05 | 5.205E-04 | PLA2G1B, MAPK1, RELA, NFKB1 |
| 09160 Human Diseases | 09161 Cancers | hsa05220 | Chronic myeloid leukemia | 4.335E-05 | 4.804E-04 | MAPK1, RELA, NFKB1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05140 | Leishmaniasis | 4.335E-05 | 4.804E-04 | MAPK1, RELA, NFKB1 |
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 1.142E-04 | 8.284E-04 | MAPK1, RELA, NFKB1 |
| 09160 Human Diseases | 09161 Cancers | hsa05215 | Prostate cancer | 7.839E-05 | 6.516E-04 | MAPK1, RELA, NFKB1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05133 | Pertussis | 4.701E-05 | 4.809E-04 | MAPK1, RELA, NFKB1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04066 | HIF-1 signaling pathway | 1.211E-04 | 8.284E-04 | MAPK1, RELA, NFKB1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05132 | Salmonella infection | 7.077E-05 | 6.275E-04 | MAPK1, RELA, NFKB1 |
| 09150 Organismal Systems | 09151 Immune system | hsa04660 | T cell receptor signaling pathway | 1.246E-04 | 8.284E-04 | MAPK1, RELA, NFKB1 |
| 09150 Organismal Systems | 09151 Immune system | hsa04620 | Toll-like receptor signaling pathway | 1.318E-04 | 8.349E-04 | MAPK1, RELA, NFKB1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05142 | Chagas disease (American trypanosomiasis) | 1.246E-04 | 8.284E-04 | MAPK1, RELA, NFKB1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04668 | TNF signaling pathway | 1.471E-04 | 8.507E-04 | MAPK1, RELA, NFKB1 |
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04931 | Insulin resistance | 1.432E-04 | 8.507E-04 | PTPN1, RELA, NFKB1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05145 | Toxoplasmosis | 1.811E-04 | 9.734E-04 | MAPK1, RELA, NFKB1 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04722 | Neurotrophin signaling pathway | 1.903E-04 | 9.734E-04 | MAPK1, RELA, NFKB1 |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04210 | Apoptosis | 2.996E-04 | 1.374E-03 | MAPK1, RELA, NFKB1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04071 | Sphingolipid signaling pathway | 1.903E-04 | 9.734E-04 | MAPK1, RELA, NFKB1 |
| 09150 Organismal Systems | 09158 Development | hsa04380 | Osteoclast differentiation | 2.520E-04 | 1.224E-03 | MAPK1, RELA, NFKB1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05161 | Hepatitis B | 3.389E-04 | 1.467E-03 | MAPK1, RELA, NFKB1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05160 | Hepatitis C | 2.577E-04 | 1.224E-03 | MAPK1, RELA, NFKB1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05164 | Influenza A | 5.756E-04 | 2.320E-03 | MAPK1, RELA, NFKB1 |
| 09150 Organismal Systems | 09151 Immune system | hsa04062 | Chemokine signaling pathway | 6.980E-04 | 2.652E-03 | MAPK1, RELA, NFKB1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05152 | Tuberculosis | 6.048E-04 | 2.366E-03 | MAPK1, RELA, NFKB1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05166 | HTLV-I infection | 1.765E-03 | 5.724E-03 | POLB, RELA, NFKB1 |
| 09160 Human Diseases | 09161 Cancers | hsa05206 | MicroRNAs in cancer | 2.634E-03 | 7.614E-03 | MAPK1, NFKB1, CDC25B |
| 09160 Human Diseases | 09162 Immune diseases | hsa05321 | Inflammatory bowel disease (IBD) | 1.716E-03 | 5.706E-03 | RELA, NFKB1 |
| 09150 Organismal Systems | 09149 Aging | hsa04211 | Longevity regulating pathway - mammal | 3.548E-03 | 9.630E-03 | RELA, NFKB1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection | 1.876E-03 | 5.942E-03 | RELA, NFKB1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05134 | Legionellosis | 1.232E-03 | 4.429E-03 | RELA, NFKB1 |
| 09100 Metabolism | 09108 Metabolism of cofactors and vitamins | hsa00830 | Retinol metabolism | 1.716E-03 | 5.706E-03 | ALDH1A1, CYP3A4 |
| 09160 Human Diseases | 09161 Cancers | hsa05222 | Small cell lung cancer | 2.980E-03 | 8.433E-03 | RELA, NFKB1 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04920 | Adipocytokine signaling pathway | 1.987E-03 | 6.006E-03 | RELA, NFKB1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04064 | NF-kappa B signaling pathway | 3.474E-03 | 9.627E-03 | RELA, NFKB1 |
| 09150 Organismal Systems | 09151 Immune system | hsa04623 | Cytosolic DNA-sensing pathway | 1.664E-03 | 5.706E-03 | RELA, NFKB1 |
| 09140 Cellular Processes | 09144 Cellular community - eukaryotes | hsa04520 | Adherens junction | 2.217E-03 | 6.553E-03 | PTPN1, MAPK1 |
| 09160 Human Diseases | 09164 Substance dependence | hsa05030 | Cocaine addiction | 9.791E-04 | 3.617E-03 | RELA, NFKB1 |
| 09150 Organismal Systems | 09151 Immune system | hsa04622 | RIG-I-like receptor signaling pathway | 1.987E-03 | 6.006E-03 | RELA, NFKB1 |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00052 | Galactose metabolism | 3.661E-04 | 1.522E-03 | AKR1B10, GAA |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00591 | Linoleic acid metabolism | 3.419E-04 | 1.467E-03 | PLA2G1B, CYP3A4 |
Human Diseases Associated with the Target Proteins of the Plant
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
