CMAUP Plant Collective Molecular Activities

Plant Name: Paeonia rockii

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0065007; biological regulation	GO:0044093; positive regulation of molecular function	1.545E-06	7.794E-03	ALDH1A1, CDC25B, HTT, MAPK1, MAPT, NFKB1, PLA2G1B, PTPN1, RELA, TSHR
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	2.748E-06	7.794E-03	GPBAR1, NR1H4
BP	GO:0051179; localization	GO:0015721; bile acid and bile salt transport	3.221E-06	7.794E-03	NR1H4, SLCO1B1, SLCO1B3
BP	GO:0050896; response to stimulus	GO:0046627; negative regulation of insulin receptor signaling pathway	3.221E-06	7.794E-03	PTPN1, PTPN2, RELA
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	2.748E-06	7.794E-03	GPBAR1, NR1H4
BP	GO:0009987; cellular process	GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway	5.494E-06	9.969E-03	PTPN1, PTPN2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa04976	Bile secretion_Homo sapiens_hsa04976	5.428E-07	7.219E-05	SLCO1B1; SLCO1B3; NR1H4; CYP3A4
hsa04010	MAPK signaling pathway_Homo sapiens_hsa04010	3.255E-06	2.165E-04	MAPK1; MAPT; RELA; NFKB1; CDC25B
hsa05221	Acute myeloid leukemia_Homo sapiens_hsa05221	2.059E-05	4.804E-04	MAPK1; RELA; NFKB1
hsa05212	Pancreatic cancer_Homo sapiens_hsa05212	3.203E-05	4.804E-04	MAPK1; RELA; NFKB1
hsa04024	cAMP signaling pathway_Homo sapiens_hsa04024	3.279E-05	4.804E-04	MAPK1; RELA; NFKB1; TSHR
hsa05203	Viral carcinogenesis_Homo sapiens_hsa05203	3.682E-05	4.804E-04	POLB; MAPK1; RELA; NFKB1
hsa04621	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	2.059E-05	4.804E-04	MAPK1; RELA; NFKB1
hsa04917	Prolactin signaling pathway_Homo sapiens_hsa04917	4.159E-05	4.804E-04	MAPK1; RELA; NFKB1
hsa04662	B cell receptor signaling pathway_Homo sapiens_hsa04662	4.335E-05	4.804E-04	MAPK1; RELA; NFKB1
hsa05131	Shigellosis_Homo sapiens_hsa05131	3.059E-05	4.804E-04	MAPK1; RELA; NFKB1
hsa04014	Ras signaling pathway_Homo sapiens_hsa04014	5.479E-05	5.205E-04	PLA2G1B; MAPK1; RELA; NFKB1
hsa05220	Chronic myeloid leukemia_Homo sapiens_hsa05220	4.335E-05	4.804E-04	MAPK1; RELA; NFKB1
hsa05140	Leishmaniasis_Homo sapiens_hsa05140	4.335E-05	4.804E-04	MAPK1; RELA; NFKB1
hsa04933	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	1.142E-04	8.284E-04	MAPK1; RELA; NFKB1
hsa05215	Prostate cancer_Homo sapiens_hsa05215	7.839E-05	6.516E-04	MAPK1; RELA; NFKB1
hsa05133	Pertussis_Homo sapiens_hsa05133	4.701E-05	4.809E-04	MAPK1; RELA; NFKB1
hsa04066	HIF-1 signaling pathway_Homo sapiens_hsa04066	1.211E-04	8.284E-04	MAPK1; RELA; NFKB1
hsa05132	Salmonella infection_Homo sapiens_hsa05132	7.077E-05	6.275E-04	MAPK1; RELA; NFKB1
hsa04660	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.246E-04	8.284E-04	MAPK1; RELA; NFKB1
hsa04620	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	1.318E-04	8.349E-04	MAPK1; RELA; NFKB1
hsa05142	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	1.246E-04	8.284E-04	MAPK1; RELA; NFKB1
hsa04668	TNF signaling pathway_Homo sapiens_hsa04668	1.471E-04	8.507E-04	MAPK1; RELA; NFKB1
hsa04931	Insulin resistance_Homo sapiens_hsa04931	1.432E-04	8.507E-04	PTPN1; RELA; NFKB1
hsa05145	Toxoplasmosis_Homo sapiens_hsa05145	1.811E-04	9.734E-04	MAPK1; RELA; NFKB1
hsa04722	Neurotrophin signaling pathway_Homo sapiens_hsa04722	1.903E-04	9.734E-04	MAPK1; RELA; NFKB1
hsa04210	Apoptosis_Homo sapiens_hsa04210	2.996E-04	1.374E-03	MAPK1; RELA; NFKB1
hsa04071	Sphingolipid signaling pathway_Homo sapiens_hsa04071	1.903E-04	9.734E-04	MAPK1; RELA; NFKB1
hsa04380	Osteoclast differentiation_Homo sapiens_hsa04380	2.520E-04	1.224E-03	MAPK1; RELA; NFKB1
hsa05161	Hepatitis B_Homo sapiens_hsa05161	3.389E-04	1.467E-03	MAPK1; RELA; NFKB1
hsa05160	Hepatitis C_Homo sapiens_hsa05160	2.577E-04	1.224E-03	MAPK1; RELA; NFKB1
hsa05164	Influenza A_Homo sapiens_hsa05164	5.756E-04	2.320E-03	MAPK1; RELA; NFKB1
hsa04062	Chemokine signaling pathway_Homo sapiens_hsa04062	6.980E-04	2.652E-03	MAPK1; RELA; NFKB1
hsa05152	Tuberculosis_Homo sapiens_hsa05152	6.048E-04	2.366E-03	MAPK1; RELA; NFKB1
hsa05166	HTLV-I infection_Homo sapiens_hsa05166	1.765E-03	5.724E-03	POLB; RELA; NFKB1
hsa05206	MicroRNAs in cancer_Homo sapiens_hsa05206	2.634E-03	7.614E-03	MAPK1; NFKB1; CDC25B
hsa04151	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	3.887E-03	1.014E-02	MAPK1; RELA; NFKB1
hsa01100	Metabolic pathways_Homo sapiens_hsa01100	5.067E-03	1.272E-02	AKR1B10; PLA2G1B; GAA; ALDH1A1; CYP3A4
hsa05200	Pathways in cancer_Homo sapiens_hsa05200	5.939E-03	1.436E-02	MAPK1; NFKB1; RELA
hsa04914	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	3.849E-03	1.014E-02	MAPK1; CDC25B
hsa05321	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.716E-03	5.706E-03	RELA; NFKB1
hsa04211	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	3.548E-03	9.630E-03	RELA; NFKB1
hsa05120	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	1.876E-03	5.942E-03	RELA; NFKB1
hsa05134	Legionellosis_Homo sapiens_hsa05134	1.232E-03	4.429E-03	RELA; NFKB1
hsa00830	Retinol metabolism_Homo sapiens_hsa00830	1.716E-03	5.706E-03	ALDH1A1; CYP3A4
hsa05222	Small cell lung cancer_Homo sapiens_hsa05222	2.980E-03	8.433E-03	RELA; NFKB1
hsa04920	Adipocytokine signaling pathway_Homo sapiens_hsa04920	1.987E-03	6.006E-03	RELA; NFKB1
hsa04064	NF-kappa B signaling pathway_Homo sapiens_hsa04064	3.474E-03	9.627E-03	RELA; NFKB1
hsa05146	Amoebiasis_Homo sapiens_hsa05146	4.004E-03	1.024E-02	RELA; NFKB1
hsa04623	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.664E-03	5.706E-03	RELA; NFKB1
hsa04520	Adherens junction_Homo sapiens_hsa04520	2.217E-03	6.553E-03	PTPN1; MAPK1
hsa05162	Measles_Homo sapiens_hsa05162	7.276E-03	1.728E-02	RELA; NFKB1
hsa04932	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	8.901E-03	2.041E-02	RELA; NFKB1
hsa04270	Vascular smooth muscle contraction_Homo sapiens_hsa04270	5.711E-03	1.407E-02	PLA2G1B; MAPK1
hsa04910	Insulin signaling pathway_Homo sapiens_hsa04910	7.589E-03	1.771E-02	PTPN1; MAPK1
hsa05030	Cocaine addiction_Homo sapiens_hsa05030	9.791E-04	3.617E-03	RELA; NFKB1
hsa05169	Epstein-Barr virus infection_Homo sapiens_hsa05169	1.550E-02	3.326E-02	RELA; NFKB1
hsa05010	Alzheimer's disease_Homo sapiens_hsa05010	1.092E-02	2.462E-02	MAPK1; MAPT
hsa04622	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	1.987E-03	6.006E-03	RELA; NFKB1
hsa05202	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	1.246E-02	2.761E-02	RELA; NFKB1
hsa05168	Herpes simplex infection_Homo sapiens_hsa05168	1.312E-02	2.861E-02	RELA; NFKB1
hsa00052	Galactose metabolism_Homo sapiens_hsa00052	3.661E-04	1.522E-03	AKR1B10; GAA
hsa00591	Linoleic acid metabolism_Homo sapiens_hsa00591	3.419E-04	1.467E-03	PLA2G1B; CYP3A4
hsa00592	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.350E-02	4.960E-02	PLA2G1B

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	CYP3A4
C00-D49: Neoplasms	Solid tumours	C00-D48	MAPK1
L00-L99: Diseases of the skin and subcutaneous tissue	Inflammatory and pruritic manifestations of corticosteroid responsive dermatoses	L20-L30	PLA2G1B
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	PLA2G1B
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAPT
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MAPK1
C00-D49: Neoplasms	Cancer	C00-C96	CDC25B; MAPK1; NFKB1
I00-I99: Diseases of the circulatory system	Arteriosclerosis	I70	PLA2G1B
J00-J99: Diseases of the respiratory system	Asthma	J45	PLA2G1B
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	PLA2G1B
L00-L99: Diseases of the skin and subcutaneous tissue	Pruritus	L29	PLA2G1B
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	MAPT
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	PTPN1; PTPN1; GPBAR1; NFKB1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	PLA2G1B
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	PTPN1
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAPT
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	PTPN1
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	GPBAR1
A00-B99: Certain infectious and parasitic diseases	Visceral leishmaniasis	B55.0	PLA2G1B
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	PLA2G1B
A00-B99: Certain infectious and parasitic diseases	Infections	A00-B99	PTPN1
L00-L99: Diseases of the skin and subcutaneous tissue	Inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses of the scalp	L20-L30	PLA2G1B
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR
A00-B99: Certain infectious and parasitic diseases	Leishmaniasis	B55.0	PLA2G1B
S00-T88: Injury, poisoning and certain other consequences of external causes	Allergy	T78.4	PLA2G1B
S00-T88: Injury, poisoning and certain other consequences of external causes	Nerve injury	T14.4	PLA2G1B
NA: NA	Colour dead tissues	NA	PTPN1
L00-L99: Diseases of the skin and subcutaneous tissue	Contact dermatitis	L23, L24, L25	PLA2G1B
E00-E89: Endocrine, nutritional and metabolic diseases	Pompe's disease	E74.02	GAA

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases