Plant ID: NPO12458
Plant Latin Name: Zingiber aromaticum
Taxonomy Genus: Zingiber
Taxonomy Family: Zingiberaceae
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Indonesia; China
HTR1A; | |
TRPV1; | |
RPS6KA3; | |
PPARA; PPARD; PPARG; | |
HSD17B10; ALOX15; ALDH1A1; USP2; POLB; APEX1; | |
ALOX5; | |
SLCO1B3; SLCO1B1; | |
MCL1; GLI2; GLI1; |
Cytochrome P450 Enzymes: | CYP2D6; |
---|
Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|
Cytochrome P450 family 2 | CYP2D6 | Cytochrome P450 2D6 | P10635 | CHEMBL289 |
Enzyme_unclassified | HSD17B10 | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | Q99714 | CHEMBL4159 |
Enzyme_unclassified | ALOX15 | Arachidonate 15-lipoxygenase | P16050 | CHEMBL2903 |
Enzyme_unclassified | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P00352 | CHEMBL3577 |
Enzyme_unclassified | USP2 | Ubiquitin carboxyl-terminal hydrolase 2 | O75604 | CHEMBL1293227 |
Enzyme_unclassified | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
Enzyme_unclassified | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | P27695 | CHEMBL5619 |
Nuclear hormone receptor subfamily 1 group C | PPARA | Peroxisome proliferator-activated receptor alpha | Q07869 | CHEMBL239 |
Nuclear hormone receptor subfamily 1 group C | PPARD | Peroxisome proliferator-activated receptor delta | Q03181 | CHEMBL3979 |
Nuclear hormone receptor subfamily 1 group C | PPARG | Peroxisome proliferator-activated receptor gamma | P37231 | CHEMBL235 |
Oxidoreductase | ALOX5 | Arachidonate 5-lipoxygenase | P09917 | CHEMBL215 |
Protein Kinase | RPS6KA3 | Ribosomal protein S6 kinase alpha 3 | P51812 | CHEMBL2345 |
SLC superfamily of solute carriers | SLCO1B3 | Solute carrier organic anion transporter family member 1B3 | Q9NPD5 | CHEMBL1743121 |
SLC superfamily of solute carriers | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | Q9Y6L6 | CHEMBL1697668 |
Small molecule receptor (family A GPCR) | HTR1A | Serotonin 1a (5-HT1a) receptor | P08908 | CHEMBL214 |
Transient receptor potential channel | TRPV1 | Vanilloid receptor | Q8NER1 | CHEMBL4794 |
Unclassified | MCL1 | Induced myeloid leukemia cell differentiation protein Mcl-1 | Q07820 | CHEMBL4361 |
Unclassified | GLI2 | Zinc finger protein GLI2 | P10070 | CHEMBL5119 |
Unclassified | GLI1 | Zinc finger protein GLI1 | P08151 | CHEMBL5461 |
GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|
BP | GO:0032502; developmental process | GO:0060032; notochord regression | 9.167E-07 | 2.753E-03 | GLI1, GLI2 |
BP | GO:0009987; cellular process | GO:0006286; base-excision repair, base-free sugar-phosphate removal | 9.167E-07 | 2.753E-03 | APEX1, POLB |
BP | GO:0008152; metabolic process | GO:0055114; oxidation-reduction process | 1.012E-06 | 2.753E-03 | ALDH1A1, ALOX15, ALOX5, APEX1, CYP2D6, HSD17B10, PPARD, PPARG |
BP | GO:0032502; developmental process | GO:0007418; ventral midline development | 2.748E-06 | 4.987E-03 | GLI1, GLI2 |
BP | GO:0050896; response to stimulus | GO:0010033; response to organic substance | 5.305E-06 | 7.476E-03 | ALOX15, APEX1, GLI2, MCL1, POLB, PPARA, PPARD, PPARG, RPS6KA3, TRPV1 |
BP | GO:0023052; signaling | GO:0021938; smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation | 5.494E-06 | 7.476E-03 | GLI1, GLI2 |
MF | GO:0140110; transcription regulator activity | GO:0004879; nuclear receptor activity | 1.445E-05 | 1.123E-02 | PPARA, PPARD, PPARG |
MF | GO:0060089; molecular transducer activity | GO:0003707; steroid hormone receptor activity | 2.533E-05 | 1.576E-02 | PPARA, PPARD, PPARG |
CC | GO:0043226; organelle | GO:0005654; nucleoplasm | 2.965E-05 | 1.745E-02 | ALOX5, APEX1, GLI1, GLI2, MCL1, POLB, PPARA, PPARD, PPARG, RPS6KA3, USP2 |
MF | GO:0005488; binding | GO:0046914; transition metal ion binding | 4.415E-05 | 2.404E-02 | ALOX15, ALOX5, CYP2D6, GLI2, PPARA, PPARD, PPARG |
MF | GO:0005488; binding | GO:0036041; long-chain fatty acid binding | 5.015E-05 | 2.457E-02 | PPARD, PPARG |
MF | GO:0003824; catalytic activity | GO:0016491; oxidoreductase activity | 5.077E-05 | 2.457E-02 | ALDH1A1, ALOX15, ALOX5, APEX1, CYP2D6, HSD17B10 |
Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|---|
09150 Organismal Systems | 09156 Nervous system | hsa04726 | Serotonergic synapse | 3.385E-06 | 1.591E-04 | CYP2D6, ALOX5, ALOX15, HTR1A |
09150 Organismal Systems | 09152 Endocrine system | hsa03320 | PPAR signaling pathway | 3.660E-05 | 8.602E-04 | PPARG, PPARA, PPARD |
09160 Human Diseases | 09161 Cancers | hsa05200 | Pathways in cancer | 4.679E-04 | 5.498E-03 | PPARG, GLI1, PPARD, GLI2 |
09130 Environmental Information Processing | 09132 Signal transduction | hsa04024 | cAMP signaling pathway | 8.360E-04 | 7.858E-03 | HTR1A, PPARA, GLI1 |
09120 Genetic Information Processing | 09124 Replication and repair | hsa03410 | Base excision repair | 4.436E-04 | 5.498E-03 | POLB, APEX1 |
09100 Metabolism | 09103 Lipid metabolism | hsa00590 | Arachidonic acid metabolism | 1.563E-03 | 9.182E-03 | ALOX5, ALOX15 |
09160 Human Diseases | 09161 Cancers | hsa05217 | Basal cell carcinoma | 1.232E-03 | 8.273E-03 | GLI1, GLI2 |
09130 Environmental Information Processing | 09132 Signal transduction | hsa04340 | Hedgehog signaling pathway | 1.019E-03 | 7.985E-03 | GLI1, GLI2 |
09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 2.043E-03 | 1.067E-02 | SLCO1B1, SLCO1B3 |
09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04931 | Insulin resistance | 4.737E-03 | 2.226E-02 | RPS6KA3, PPARA |
ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
---|---|---|---|
G00-G99: Diseases of the nervous system G00-G99 | Neuropathic pain | G64, G90.0 | TRPV1; |
L00-L99: Diseases of the skin and subcutaneous tissue | Atopic dermatitis | L00-L99 | TRPV1; |
N00-N99: Diseases of the genitourinary system | Urinary incontinence | N39.3, N39.4, R32 | TRPV1; |
C00-D49: Neoplasms | Overactive bladder disorder | C67, N32.81 | TRPV1; |
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Musculoskeletal pain | R52, G89 | TRPV1; |
G00-G99: Diseases of the nervous system G00-G99 | Pain | G64, G90.0, R52, G89 | TRPV1; |
NA: NA | Esophagus sensitivity | NA | TRPV1; |
A00-B99: Certain infectious and parasitic diseases | Postherpetic neuralgia | B02.2, G44.847, G53.0 | TRPV1; |
J00-J99: Diseases of the respiratory system | Asthma | J45 | TRPV1; |
G00-G99: Diseases of the nervous system G00-G99 | Acute migraine | G43 | TRPV1; |
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Acute or chronic pain | R52, G89 | TRPV1; |
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Chronic pathological pain | R52, G89 | TRPV1; |
K00-K95: Diseases of the digestive system | Gastroesophageal reflux disease | K21 | TRPV1; |
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Cough | R05 | TRPV1; |
E00-E89: Endocrine, nutritional and metabolic diseases | Diabetic neuropathy | E11.40 | TRPV1; |