CMAUP Plant Collective Molecular Activities

Plant Name: Zingiber aromaticum

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0032502; developmental process	GO:0060032; notochord regression	9.167E-07	2.753E-03	GLI1, GLI2
BP	GO:0009987; cellular process	GO:0006286; base-excision repair, base-free sugar-phosphate removal	9.167E-07	2.753E-03	APEX1, POLB
BP	GO:0008152; metabolic process	GO:0055114; oxidation-reduction process	1.012E-06	2.753E-03	ALDH1A1, ALOX15, ALOX5, APEX1, CYP2D6, HSD17B10, PPARD, PPARG
BP	GO:0032502; developmental process	GO:0007418; ventral midline development	2.748E-06	4.987E-03	GLI1, GLI2
BP	GO:0050896; response to stimulus	GO:0010033; response to organic substance	5.305E-06	7.476E-03	ALOX15, APEX1, GLI2, MCL1, POLB, PPARA, PPARD, PPARG, RPS6KA3, TRPV1
BP	GO:0023052; signaling	GO:0021938; smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation	5.494E-06	7.476E-03	GLI1, GLI2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa04726	Serotonergic synapse_Homo sapiens_hsa04726	3.385E-06	1.591E-04	CYP2D6; ALOX5; ALOX15; HTR1A
hsa03320	PPAR signaling pathway_Homo sapiens_hsa03320	3.660E-05	8.602E-04	PPARG; PPARA; PPARD
hsa05200	Pathways in cancer_Homo sapiens_hsa05200	4.679E-04	5.498E-03	PPARG; GLI1; PPARD; GLI2
hsa04024	cAMP signaling pathway_Homo sapiens_hsa04024	8.360E-04	7.858E-03	HTR1A; PPARA; GLI1
hsa03410	Base excision repair_Homo sapiens_hsa03410	4.436E-04	5.498E-03	POLB; APEX1
hsa00590	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.563E-03	9.182E-03	ALOX5; ALOX15
hsa05217	Basal cell carcinoma_Homo sapiens_hsa05217	1.232E-03	8.273E-03	GLI1; GLI2
hsa04340	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.019E-03	7.985E-03	GLI1; GLI2
hsa04976	Bile secretion_Homo sapiens_hsa04976	2.043E-03	1.067E-02	SLCO1B1; SLCO1B3
hsa04931	Insulin resistance_Homo sapiens_hsa04931	4.737E-03	2.226E-02	RPS6KA3; PPARA

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	ALOX5
K00-K95: Diseases of the digestive system	Inflammatory bowel disease	K50, K51	PPARG
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	ALOX5
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CYP2D6
G00-G99: Diseases of the nervous system G00-G99	Migraine	G43	HTR1A; CYP2D6
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	PPARG
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	PPARD
E00-E89: Endocrine, nutritional and metabolic diseases	Dyslipidaemias	E78	PPARD; PPARD
E00-E89: Endocrine, nutritional and metabolic diseases	Eating disorder	E66, F50, I10-I16, I50	HTR1A
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	TRPV1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Nicotine dependence	F17	PPARG
NA: NA	Cervical dystonia	NA	HTR1A
A00-B99: Certain infectious and parasitic diseases	Lymphatic filariasis	B74	ALOX5
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	PPARD; PPARD; PPARG
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	HTR1A; HTR1A
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	CYP2D6
NA: NA	Anxiety disorders	NA	HTR1A
I00-I99: Diseases of the circulatory system	Thrombosis	I80-I82	ALOX5
L00-L99: Diseases of the skin and subcutaneous tissue	Atopic dermatitis	L00-L99	ALOX5; TRPV1
H00-H59: Diseases of the eye and adnexa	Ocular inflammation	H16.229	PPARG
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Spasm	R25.2	HTR1A
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	ALOX5; PPARD
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	ALOX5
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	ALOX5
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	PPARG
N00-N99: Diseases of the genitourinary system	Urinary incontinence	N39.3, N39.4, R32	HTR1A; TRPV1
K00-K95: Diseases of the digestive system	Non-alcoholic fatty liver disease	K76.0	PPARD; PPARG
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	HTR1A
C00-D49: Neoplasms	Overactive bladder disorder	C67, N32.81	TRPV1; TRPV1
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Musculoskeletal pain	R52, G89	TRPV1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Hypoactive sexual desire disorder	F52.0	HTR1A
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	HTR1A
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	HTR1A; TRPV1; TRPV1
I00-I99: Diseases of the circulatory system	Coronary artery disease	I20-I25	HTR1A
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mood disorder	F30-F39	HTR1A
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	PPARD
NA: NA	Episode	NA	HTR1A
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	HTR1A; HTR1A
NA: NA	Peripheral sensory neuropathies	NA	HTR1A
NA: NA	Esophagus sensitivity	NA	TRPV1
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	HTR1A; HTR1A; PPARG; PPARG
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	ALOX5
J00-J99: Diseases of the respiratory system	Rhinitis	J00, J30, J31.0	ALOX5
NA: NA	Schizoaffective disorder	NA	HTR1A
A00-B99: Certain infectious and parasitic diseases	Postherpetic neuralgia	B02.2, G44.847, G53.0	TRPV1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Premature ejaculation	F52.4	HTR1A
A00-B99: Certain infectious and parasitic diseases	Fungal infections	B35-B49	ALOX5
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Female sexual dysfunction	F52	HTR1A
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Severe mood disorders	F30-F39	HTR1A; HTR1A
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychiatric disorder	F01-F99	HTR1A
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychotic disorders	F20-F29	HTR1A
J00-J99: Diseases of the respiratory system	Asthma	J45	ALOX5; ALOX5; TRPV1
G00-G99: Diseases of the nervous system G00-G99	Acute migraine	G43	TRPV1
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Acute or chronic pain	R52, G89	TRPV1
L00-L99: Diseases of the skin and subcutaneous tissue	Pruritus	L29	ALOX5
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	ALOX5
NA: NA	Social phobia	NA	HTR1A
NA: NA	Dyslipidemia	NA	PPARD
C00-D49: Neoplasms	Ocular cancer	C69	APEX1
E00-E89: Endocrine, nutritional and metabolic diseases	Type 1 diabetes	E10	PPARD; PPARG
J00-J99: Diseases of the respiratory system	Respiratory disease	J00-J99	ALOX5
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	PPARD
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	HTR1A
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Chronic pathological pain	R52, G89	TRPV1
K00-K95: Diseases of the digestive system	Gastroesophageal reflux disease	K21	TRPV1
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	ALOX5
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Drug abuse	F10-F19	PPARG
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	HTR1A
G00-G99: Diseases of the nervous system G00-G99	Lateral sclerosis	G12.2	HTR1A
L00-L99: Diseases of the skin and subcutaneous tissue	Dermatitis	L20-L30	ALOX5
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	HTR1A
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	PPARG
S00-T88: Injury, poisoning and certain other consequences of external causes	Allergy	T78.4	ALOX5
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Cough	R05	TRPV1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Generalized anxiety disorder	F32, F40-F42, F41.1	HTR1A; HTR1A
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	TRPV1
NA: NA	Bulimia nervosa	NA	HTR1A
C00-D49: Neoplasms	Cancer	C00-C96	MCL1
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	PPARD; PPARG; PPARG

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases