Prescription Description
| Prescription ID | TCMFx4740 |
| Pinyin Name | Nao Li Qing Pian |
| Chinese Name | 脑立清片 |
| English Name | Nao Li Qing Tablets |
| Function Description | 眩晕, 耳鸣, ä¸å¯ |
| Indications | Tinnitus disorder, Vertigo disorder, Insomnia disorder, Insomnia, Tinnitus, Dizziness |
| Disease ICD-11 Category |
SC75 [Tinnitus disorder (TM1), 耳鸣 (TM1)
]; SD22 [Vertigo disorder (TM1), 眩晕 (TM1) ]; SD84 [Insomnia disorder (TM1), ä¸å¯ (TM1) ]; 7A0Z [Insomnia disorders, unspecified, å¤±çœ éšœç¢ï¼Œæœªç‰¹æŒ‡çš„ ]; MC41 [Tinnitus, 耳鸣 ]; MB48 [Dizziness and giddiness, 头晕和眩晕 ]; |
| Human Tissues Associated with Indication | Brain, Heart |
| Reference | CFDA |
| Reference Book/link | http://samr.cfda.gov.cn/WS01/CL0001/ |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH324 | Magnetitum | ç£çŸ³ | TCMH324 | |
| TCMH1677 | Pinellia ternata | 清åŠå¤ | TCMH1677 | GBVT1123-13, GBVY1693-14 |
| TCMH1168 | NA | 酒曲 | TCMH1168 | |
| TCMH1588 | Achyranthes bidentata | ç‰›è† | TCMH1588 | ITSAJ4612-14 |
| TCMH189 | Mentholum | è–„è·è„‘ | TCMH189 | |
| TCMH183 | Dryobalanops aromatica | 冰片 | TCMH183 | GBVK4926-11 |
| TCMH2601 | Haematitum | èµçŸ³ | TCMH2601 | |
| TCMH2610 | Concha margaritifera usta;Margarita | çç æ¯ | TCMH2610 | |
| TCMH2695 | NA | 猪胆 | TCMH2695 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
| TCMT107 | GRIK2 | Glutamate receptor ionotropic kainate 2 | Ion channel | Q13002 |
| TCMT109 | GRIA2 | Glutamate receptor ionotropic, AMPA 2 | Ion channel | P42262 |
| TCMT110 | GRIA4 | Glutamate receptor ionotropic, AMPA 4 | Ion channel | P48058 |
| TCMT111 | GRIK5 | Glutamate receptor ionotropic kainate 5 | Ion channel | Q16478 |
| TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
| TCMT134 | CA2 | Carbonic anhydrase II | Lyase | P00918 |
| TCMT135 | CA14 | Carbonic anhydrase XIV | Lyase | Q9ULX7 |
| TCMT190 | PTPN2 | T-cell protein-tyrosine phosphatase | Hydrolase | P17706 |
| TCMT280 | AKR1B10 | Aldo-keto reductase family 1 member B10 | Oxidoreductase | O60218 |
| TCMT296 | ADORA1 | Adenosine A1 receptor | GPCR | P30542 |
| TCMT297 | FABP4 | Fatty acid binding protein adipocyte | Unclassified | P15090 |
| TCMT298 | FABP3 | Fatty acid binding protein muscle | Hydrolase | P05413 |
| TCMT563 | CDC25B | Dual specificity phosphatase Cdc25B | Hydrolase | P30305 |
| TCMT571 | ADORA2B | Adenosine A2b receptor | GPCR | P29275 |
| TCMT597 | SLC28A3 | Solute carrier family 28 member 3 | Transporter | Q9HAS3 |
| TCMT637 | SIRT3 | NAD-dependent deacetylase sirtuin 3 | Hydrolase | Q9NTG7 |
| TCMT638 | SIRT2 | NAD-dependent deacetylase sirtuin 2 | Hydrolase | Q8IXJ6 |
| TCMT653 | GRM1 | Metabotropic glutamate receptor 1 | GPCR | Q13255 |
| TCMT654 | GRM5 | Metabotropic glutamate receptor 5 | GPCR | P41594 |
| TCMT655 | GRM2 | Metabotropic glutamate receptor 2 | GPCR | Q14416 |
| TCMT656 | GRM3 | Metabotropic glutamate receptor 3 | GPCR | Q14832 |
| TCMT657 | GRM4 | Metabotropic glutamate receptor 4 | GPCR | Q14833 |
| TCMT660 | GRM8 | Metabotropic glutamate receptor 8 | GPCR | O00222 |
| TCMT664 | SLC1A1 | Excitatory amino acid transporter 3 | Transporter | P43005 |
| TCMT709 | SLC28A2 | Sodium/nucleoside cotransporter 2 | Transporter | O43868 |
| TCMT710 | SLC28A1 | Sodium/nucleoside cotransporter 1 | Transporter | O00337 |
| TCMT808 | FABP5 | Fatty acid binding protein epidermal | Unclassified | Q01469 |
| TCMT809 | FABP2 | Fatty acid binding protein intestinal | Unclassified | P12104 |
| TCMT810 | TLR2 | Toll-like receptor 2 | Unclassified | O60603 |
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1178 | Actinomyces viscosus |
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
| TCMT1218 | Staphylococcus aureus |
| TCMT1221 | Human herpesvirus 4 |
| TCMT1226 | Klebsiella pneumoniae |
| TCMT1229 | Enterococcus faecalis |
| TCMT1231 | Human herpesvirus 1 strain KOS |
| TCMT1232 | Pseudomonas aeruginosa |
| TCMT1245 | Phytophthora cactorum |
| TCMT1246 | Escherichia coli |
| TCMT1247 | Human herpesvirus 1 |
| TCMT1248 | Hepatitis C virus |
| TCMT1251 | Candida albicans |
| TCMT1253 | Penicillium chrysogenum |
| TCMT1255 | Human immunodeficiency virus 1 |
| TCMT1294 | Human parainfluenza virus 3 |
| TCMT1361 | Neisseria meningitidis |
| TCMT1382 | Plasmodium falciparum (isolate K1 / Thailand) |
| TCMT1390 | Human herpesvirus 2 strain G |
| TCMT1408 | Colletotrichum gloeosporioides |
| TCMT1438 | Plasmodium falciparum |
| TCMT1442 | Leishmania donovani |
| TCMT1454 | Bacillus subtilis |
| TCMT1455 | Mycobacterium tuberculosis H37Rv |
| TCMT1458 | Filobasidiella neoformans |
| TCMT1462 | Streptococcus mutans |
| TCMT1463 | Mycobacterium tuberculosis |
| TCMT1464 | Hepatitis B virus |
| TCMT1465 | Entamoeba histolytica |
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples