TCM Prescription: Xiao Shi Tui Re Syrup



Prescription Description
Prescription IDTCMF943
Pinyin NameXiao Shi Tui Re Tang Jiang 
Chinese Name消食退热糖浆
English NameXiao Shi Tui Re Syrup
Function Description小儿呼吸道, 消化道急性感染
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH228 Bupleurum chinense 柴胡 TCMH228 ITSAM2218-14
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
TCMH1681 Artemisia carvifolia 青蒿 TCMH1681 KU555619
TCMH182 Areca catechu 槟榔 TCMH182 ITSAA732-14
TCMH890 Cortex magnoliae officinalis 厚朴 TCMH890 ITSAM1591-14
TCMH1513 Paeonia moutan 牡丹皮 TCMH1513
TCMH1142 Schizonepetae spica 荆芥穗 TCMH1142
TCMH363 Rheum officinale 大黄 TCMH363 ITSAJ4685-14
TCMH2624 Anemarrhena asphodeloides 知母 TCMH2624 GBVA3255-11, GBVU1201-13
TCMH1999 Bubalus bubalis 水牛角浓缩粉 TCMH1999 GBMA0080-06
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT186 MAOB Monoamine oxidase B Oxidoreductase P27338
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT243 ADRA2C Alpha-2c adrenergic receptor GPCR P18825
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT273 NR1H4 Bile acid receptor FXR Nuclear receptor Q96RI1
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT39 PDE5A Phosphodiesterase 5A Hydrolase O76074
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT551 CHRM4 Muscarinic acetylcholine receptor M4 GPCR P08173
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT588 DAO D-amino-acid oxidase Oxidoreductase P14920
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT598 TOP1 DNA topoisomerase I Isomerase P11387
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT645 HTR1E Serotonin 1e (5-HT1e) receptor GPCR P28566
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT69 THRB Thyroid hormone receptor beta-1 Nuclear receptor P10828
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT796 PCNA Proliferating cell nuclear antigen Unclassified P12004
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT815 HTR1D Serotonin 1d (5-HT1d) receptor GPCR P28221
TCMT816 HTR1B Serotonin 1b (5-HT1b) receptor GPCR P28222
TCMT817 HTR4 Serotonin 4 (5-HT4) receptor GPCR Q13639
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT864 THRA Thyroid hormone receptor alpha Nuclear receptor P10827
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1177 Haemophilus influenzae
TCMT1178 Actinomyces viscosus
TCMT1182 Streptococcus sanguinis
TCMT1183 Candida albicans SC5314
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1193 Staphylococcus
TCMT1194 Shigella sonnei
TCMT1195 Streptococcus pasteurianus
TCMT1196 Salmonella
TCMT1197 Shigella sp.
TCMT1198 Serratia marcescens
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1283 Human enterovirus 71
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1319 Corynebacterium xerosis
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADRA2A, ADRA2C, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA12, CA2, CA7, CHRM1, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, F10, FABP3, FABP4, FLT3, GPR35, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSPA1A, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR4, HTR7, INSR, KDR, KIT, MAOB, MET, NR1H4, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SMAD3, SRC, TEK, THRA, THRB, TNKS, TNKS2, XDH 18.0342
[BP] GO:0007210 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.111
[BP] GO:0098664 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.111
[BP] GO:0010647 positive regulation of cell communication ADRA2A, ADRA2C, AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, FLT3, GPR35, HCAR2, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, KIT, MET, MMP12, MMP9, NR1H4, PDE5A, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 14.0855
[BP] GO:0023056 positive regulation of signaling ADRA2A, ADRA2C, AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, FLT3, GPR35, HCAR2, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, KIT, MET, MMP12, MMP9, NR1H4, PDE5A, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 14.0582
[BP] GO:0042221 response to chemical ABCB1, ADRA2A, AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, FABP4, FLT3, HSD11B2, HSPA1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IGF1R, INSR, KDR, KIT, MAOB, MMP2, MMP9, NR1H4, PIK3CA, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TOP1 13.0428
[BP] GO:0010646 regulation of cell communication ACHE, ADRA2A, ADRA2C, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, F10, FLT3, GPR35, HCAR2, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NR1H4, NUAK1, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPRS, SMAD3, SRC, TEK, THRA, TNKS, TNKS2, XDH 12.628
[BP] GO:0023051 regulation of signaling ACHE, ADRA2A, ADRA2C, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, F10, FLT3, GPR35, HCAR2, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NR1H4, NUAK1, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPRS, SMAD3, SRC, TEK, THRA, TNKS, TNKS2, XDH 12.4292
[BP] GO:0009967 positive regulation of signal transduction ADRA2A, ADRA2C, AKR1B1, ALOX15, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, F10, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, KIT, MET, MMP12, MMP9, NR1H4, PDE5A, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 11.9024
[BP] GO:0007187 None ADRA2A, ADRA2C, CHRM1, CHRM2, CHRM4, CNR1, CNR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR4, HTR5A, HTR6, HTR7 11.292
[BP] GO:0010033 response to organic substance ADRA2A, AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, FABP4, FLT3, HSD11B2, HSPA1A, HTR1B, HTR5A, IGF1R, INSR, KDR, KIT, MAOB, MMP2, NR1H4, PIK3CA, PPARA, PTGS2, RORC, SMAD3, SRC, TEK 10.8259
[BP] GO:0032501 multicellular organismal process ADRA2A, ADRA2C, AKR1B1, ALOX15, ALOX5, ALPL, AXL, BCL2, CHRM1, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, F10, FABP4, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR7, IGF1R, INSR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PDE5A, PIK3CA, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, THRA, THRB, TNKS2, TOP1 10.8259
[BP] GO:1902533 positive regulation of intracellular signal transduction ADRA2A, ADRA2C, AKR1B1, ALOX15, AXL, BCL2, CYP1B1, EGFR, F10, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, KIT, MET, PDE5A, PIK3CA, PIK3CB, PTGS2, SRC, TEK, XDH 10.8259
[BP] GO:0048522 positive regulation of cellular process ACHE, ADRA2A, ADRA2C, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, F10, FABP3, FLT3, GPR35, HCAR2, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, THRA, THRB, TNKS, TNKS2, XDH 10.5557
[BP] GO:1902531 regulation of intracellular signal transduction ADRA2A, ADRA2C, AKR1B1, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, F10, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MET, MMP9, NR1H4, NUAK1, PDE5A, PIK3CA, PIK3CB, PTGS2, SRC, TEK, XDH 10.543
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA3, ADRA2A, ADRA2C, ALOX15, AXL, BCL2, CA2, CA7, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, GPR35, HCAR2, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAOB, MET, MMP12, MMP9, NR1H4, PIK3CB, PPARA, PTGS2, SMAD3, SRC, TEK, THRA 10.0717
[BP] GO:0009719 response to endogenous stimulus ADRA2A, AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, IGF1R, INSR, KIT, MAOB, MMP2, NR1H4, PPARA, PTGS2, SMAD3, SRC, TEK 9.93848
[BP] GO:0009725 response to hormone ADRA2A, AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, INSR, KIT, MAOB, PPARA, PTGS2, SRC, TEK 9.93195
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, BCL2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, HSD11B2, HTR1B, HTR5A, IGF1R, INSR, MAOB, MMP2, MMP9, NR1H4, PIK3CA, PPARA, PTGS2, RORC, SRC, TEK 9.83104
[BP] GO:0048584 positive regulation of response to stimulus ADRA2A, ADRA2C, AKR1B1, ALOX15, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, F10, FABP4, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, KIT, MET, MMP12, MMP2, MMP9, NR1H4, PDE5A, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 9.82246
[BP] GO:0003018 None ADRA2A, ADRA2C, CHRM1, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SRC, TEK 9.78571
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, NR1H4, SRC, TEK 9.76654
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADRA2A, ADRA2C, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, GPR35, HCAR2, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, THRA, THRB, TNKS, TNKS2, XDH 9.6019
[BP] GO:0042127 regulation of cell proliferation ADORA3, ADRA2A, AKR1B1, BCL2, CHRM1, CSNK2A1, CYP1B1, EGFR, ESR1, FABP3, FLT3, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, INSR, KDR, KIT, MMP12, MMP2, MMP9, NUAK1, PDE5A, PIM1, PTGS1, PTGS2, SMAD3, SRC, TEK, XDH 9.59014
[BP] GO:0019216 regulation of lipid metabolic process ADRA2A, CNR1, CYP1A1, FABP3, FLT3, HCAR2, HTR2A, HTR2B, HTR2C, KIT, NR1H4, PPARA, PTGS2, RORC, SRC, TEK, THRA 9.4541
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, MAOB, NR1H4, PTGS2, RORC, SRC 9.26496
[BP] GO:0007193 None ADRA2A, CHRM1, CHRM2, CHRM4, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 9.05334
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADRA2A, ADRA2C, AKR1B1, ALOX15, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, F10, FABP4, FLT3, GPR35, HSPA1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP2, MMP9, NR1H4, NUAK1, PDE5A, PIK3CA, PIK3CB, PPARA, PTGS2, PTPRS, SMAD3, SRC, TEK, THRA, TNKS, TNKS2, XDH 9.03393
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, ALOX15, ALOX5, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD11B2, HSD17B1, KIT, MET, NR1H4, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TBXAS1 8.91249
[BP] GO:0007165 signal transduction ADORA3, ADRA2A, ADRA2C, AKR1B1, AXL, BCL2, CA1, CA2, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GPR35, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, NR1H4, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, RORC, SMAD3, SRC, TEK, THRA, THRB, TNKS, TNKS2 8.69281
[BP] GO:0032844 regulation of homeostatic process ADRA2A, AURKB, BCL2, CA2, CA7, CNR1, EGFR, HCAR2, HTR2A, HTR2B, HTR2C, KDR, NR1H4, PIK3CB, PTGS2, SRC, TNKS, TNKS2 8.69135
[BP] GO:0007188 None ADRA2A, ADRA2C, CHRM1, CHRM2, CHRM4, CNR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 8.55056
[BP] GO:0003013 None ADRA2A, ADRA2C, CHRM1, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SRC, TEK 8.39852
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, NR1H4, PPARA, PTGS2, SRC, TEK 8.39096
[BP] GO:0097746 None ADRA2A, ADRA2C, CHRM1, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 8.36721
[BP] GO:0035296 None ADRA2A, ADRA2C, CHRM1, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 8.36721
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA3, ADRA2A, ADRA2C, CA2, CHRM1, CHRM2, CHRM4, CNR1, CNR2, ESR1, GPR35, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, INSR, PIK3CA, PIK3CB, SRC 8.34049
[BP] GO:0042493 response to drug ABCB1, AKR1B1, AXL, BCL2, CA9, CNR1, CNR2, CYP1A1, CYP1B1, EGFR, FABP3, HSD11B2, HTR1B, HTR2A, HTR2B, HTR2C, KDR, MAOB, PTGS2, SRC, TOP1 8.30398
[BP] GO:0010817 regulation of hormone levels ACHE, ADRA2A, ADRA2C, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, HCAR2, HSD11B1, HSD11B2, HSD17B1, HTR1A, HTR2A, HTR2C, NR1H4 8.28007
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADRA2A, ADRA2C, ALOX15, AXL, BCL2, CA2, CA7, CHRM1, CNR1, CYP19A1, EGFR, GPR35, HCAR2, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, INSR, MAOB, MMP12, MMP9, NR1H4, PIK3CB, PPARA, PTGS2, SMAD3, SRC, THRA 8.28007
[BP] GO:0050880 None ADRA2A, ADRA2C, CHRM1, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 8.11116
[BP] GO:0009966 regulation of signal transduction ADRA2A, ADRA2C, AKR1B1, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, F10, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NR1H4, NUAK1, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPRS, SMAD3, SRC, TEK, THRA, TNKS, TNKS2, XDH 8.10425
[BP] GO:0035150 None ADRA2A, ADRA2C, CHRM1, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 8.08844
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA3, ADRA2A, AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA9, CHRM2, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, F10, FABP3, FABP4, FLT3, HSD11B2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IGF1R, INSR, KDR, KIT, MAOB, MMP12, MMP2, MMP9, NR1H4, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, RORC, SMAD3, SRC, TEK, THRA, TOP1 8.0602
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, NR1H4, SRC, TEK 7.89226
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, BCL2, CHRM1, CSNK2A1, EGFR, ESR1, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, INSR, KDR, KIT, MMP12, MMP2, MMP9, PIM1, PTGS2, TEK 7.73261
[BP] GO:0019220 regulation of phosphate metabolic process ADRA2A, ADRA2C, ALOX15, BCL2, DUSP3, EGFR, FABP3, FABP4, FLT3, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MMP9, NR1H4, NUAK1, PDE5A, PIK3CA, PIK3CB, PPARA, PTGS2, SMAD3, SRC, TEK, XDH 7.6222
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FLT3, HSD11B2, HTR1B, HTR5A, MAOB, PTGS2, RORC, SRC, TEK 7.59384
[BP] GO:0043067 regulation of programmed cell death AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, HCAR2, HSPA1A, HTR2B, IGF1R, KDR, KIT, MET, MMP9, NR1H4, PIK3CA, PIK3CB, PIM1, PTGS2, SMAD3, SRC, TEK, THRA, XDH 7.55816
[BP] GO:0051174 regulation of phosphorus metabolic process ADRA2A, ADRA2C, ALOX15, BCL2, DUSP3, EGFR, FABP3, FABP4, FLT3, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MMP9, NR1H4, NUAK1, PDE5A, PIK3CA, PIK3CB, PPARA, PTGS2, SMAD3, SRC, TEK, XDH 7.55816
[BP] GO:0010941 regulation of cell death AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, HCAR2, HSPA1A, HTR2B, IGF1R, KDR, KIT, MET, MMP9, NR1H4, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, SMAD3, SRC, TEK, THRA, XDH 7.5341
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TBXAS1 7.4493
[BP] GO:0071073 None FABP3, HTR2A, HTR2B, HTR2C, NR1H4 7.20312
[BP] GO:0044281 small molecule metabolic process AKR1B1, ALOX15, ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, FABP3, FUT7, HSPA1A, HTR2B, HTR2C, NR1H4, PDE5A, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, XDH 7.08455
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, ALOX15, ALPL, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, HTR1B, IGF1R, INSR, KDR, KIT, MMP2, MMP9, NR1H4, PIK3CA, PTGS2, RORC, SMAD3, SRC 7.08455
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, KIT, MAOB, MMP9, PTGS2, SRC 7.08455
[BP] GO:0007198 None HTR1A, HTR1B, HTR5A, HTR7 6.9671
[BP] GO:0097756 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 6.92157
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TBXAS1 6.80377
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADRA2A, ADRA2C, ALOX15, BCL2, EGFR, FABP3, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MMP9, NR1H4, PDE5A, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, XDH 6.80049
[BP] GO:0045937 positive regulation of phosphate metabolic process ADRA2A, ADRA2C, ALOX15, BCL2, EGFR, FABP3, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MMP9, NR1H4, PDE5A, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, XDH 6.80049
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA3, ADRA2A, ADRA2C, AKR1B1, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FABP4, GPR35, HSPA1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAOB, MET, MMP12, MMP9, NR1H4, PDE5A, PIK3CA, PIM1, PPARA, PTGS2, PTPRS, RORC, SMAD3, SRC, TEK, THRA, THRB, TNKS, TNKS2, XDH 6.75592
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, ALOX15, ALPL, AXL, BCL2, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, FLT3, HTR1B, IGF1R, INSR, KDR, KIT, MMP2, NR1H4, PIK3CA, PTGS2, RORC, SMAD3, SRC 6.72776
[BP] GO:0051239 regulation of multicellular organismal process ADORA3, ADRA2A, ADRA2C, AXL, BCL2, CA2, CHRM1, CHRM2, CNR1, CYP1B1, EGFR, ESR1, GPR35, HCAR2, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MET, MMP12, MMP9, NR1H4, PDE5A, PIK3CA, PIM1, PTGS2, PTPRS, SMAD3, SRC, TEK, THRA, THRB, TNKS2, XDH 6.67804
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.57183
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TBXAS1 6.56452
[BP] GO:0043410 positive regulation of MAPK cascade ADRA2A, ADRA2C, ALOX15, EGFR, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, PDE5A, PIK3CB, SRC, TEK, XDH 6.5113
[BP] GO:0048878 chemical homeostasis ADRA2A, AKR1B1, BCL2, CA12, CA2, CA7, CNR1, EGFR, ESR1, FABP3, FABP4, GPR35, HTR2A, HTR2B, HTR2C, INSR, MET, NR1H4, PIK3CA, PIK3CB, SMAD3 6.50912
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, BCL2, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PTGS2, PTPRS, SRC, TEK, TNKS, TOP1, XDH 6.48091
[BP] GO:0060548 negative regulation of cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, HTR2B, IGF1R, KDR, KIT, MET, MMP9, NR1H4, PIK3CA, PIM1, PPARA, PTGS2, SMAD3, SRC, TEK 6.46076
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, KIT, PIM1, SRC, TEK 6.45135
[BP] GO:0044057 None ADORA3, ADRA2A, ADRA2C, CHRM1, CHRM2, EGFR, GPR35, HCAR2, HTR2A, HTR2C, KIT, PDE5A, PTGS2, SMAD3, THRA, THRB 6.43642
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, INSR, KIT, MET, PIK3CA, PIK3CB, SRC, TEK 6.36946
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, HTR2B, IGF1R, KDR, KIT, MET, MMP9, NR1H4, PIK3CA, PIM1, PTGS2, SMAD3, SRC, TEK 6.36946
[BP] GO:0003008 None ADRA2A, ADRA2C, AKR1B1, BCL2, CHRM1, CNR1, CNR2, CYP1B1, EGFR, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, INSR, KIT, PDE5A, PIK3CA, PTGS2, SRC, TEK, THRA, THRB 6.36946
[BP] GO:0042981 regulation of apoptotic process AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, HCAR2, HSPA1A, HTR2B, IGF1R, KDR, MMP9, NR1H4, PIK3CA, PIK3CB, PIM1, PTGS2, SMAD3, SRC, TEK, THRA, XDH 6.34251
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA3, ADRA2A, ADRA2C, AKR1B1, ALOX15, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FABP4, GPR35, HCAR2, HSPA1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAOB, MET, MMP12, MMP9, NR1H4, PDE5A, PIK3CA, PIM1, PPARA, PTGS2, PTPRS, RORC, SMAD3, SRC, TEK, THRA, THRB, TNKS, TNKS2, XDH 6.24841
[BP] GO:0040012 regulation of locomotion ADORA3, ADRA2A, BCL2, CHRM1, CHRM4, CYP19A1, CYP1B1, EGFR, F10, HTR1D, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK 6.20024
[BP] GO:0042310 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7 6.15178
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, F10, INSR, KIT, MET, PIK3CA, PIK3CB, SRC, TEK, XDH 6.15178
[BP] GO:0043408 regulation of MAPK cascade ADRA2A, ADRA2C, ALOX15, DUSP3, EGFR, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, PDE5A, PIK3CB, SRC, TEK, XDH 6.11444
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA9, CBR1, CHRM1, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, FABP4, FLT3, FUT7, HSD11B1, HTR2A, HTR2B, HTR5A, INSR, KDR, KIT, MAOB, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPRS, RORC, SMAD3, SRC, TEK, THRA, THRB, TNKS2 6.10978
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, BCL2, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PTGS2, PTPRS, SRC, TEK, TNKS, TOP1, XDH 6.07615
[BP] GO:0007200 None ADRA2A, CHRM1, CHRM2, CHRM4, ESR1, HTR2A, HTR2B, HTR2C 5.92766
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, BCL2, CHRM1, CHRM4, CYP1A1, EGFR, ESR1, FLT3, HTR1A, KIT, MET, PIK3CB, PIM1, SRC, TEK 5.92008
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADRA2A, ADRA2C, ALOX15, AURKB, BCL2, CSNK2A1, EGFR, ESR1, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAOB, MET, MMP12, MMP9, NR1H4, PDE5A, PIK3CA, PIK3CB, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, THRA, THRB, TNKS, TNKS2, XDH 5.89038
[BP] GO:0042592 homeostatic process ADRA2A, AKR1B1, AXL, BCL2, CA12, CA2, CA7, CNR1, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, HTR2A, HTR2B, HTR2C, INSR, MET, NR1H4, PIK3CA, PIK3CB, SMAD3, SRC 5.88914
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, CNR1, EGFR, HCAR2, NR1H4, PIK3CB, PTGS2, TNKS, TNKS2 5.88914
[BP] GO:0071071 None FABP3, HTR2A, HTR2B, HTR2C, NR1H4 5.86106
[BP] GO:0001934 positive regulation of protein phosphorylation ADRA2A, ADRA2C, ALOX15, BCL2, EGFR, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, SRC, TEK, XDH 5.81653
[BP] GO:0044255 cellular lipid metabolic process ACHE, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FUT7, KIT, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TBXAS1 5.68635
[BP] GO:0099536 None CHRM1, CHRM2, CHRM4, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 5.67382
[BP] GO:0099537 None CHRM1, CHRM2, CHRM4, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 5.67382
[BP] GO:0030335 positive regulation of cell migration ADRA2A, BCL2, EGFR, F10, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK 5.62821
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.62821
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK 5.62821
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, FLT3, HSD11B1, INSR, KDR, KIT, PIK3CA, PPARA, PTPRS, SMAD3, SRC, TEK, THRA 5.61629
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK 5.56844
[BP] GO:0043271 negative regulation of ion transport ADRA2A, BCL2, CNR1, GPR35, HTR1B, HTR2A, MAOB, MMP9, PTGS2 5.5429
[BP] GO:0042327 positive regulation of phosphorylation ADRA2A, ADRA2C, ALOX15, BCL2, EGFR, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, SRC, TEK, XDH 5.53094
[BP] GO:0031325 positive regulation of cellular metabolic process ADRA2A, ADRA2C, ALOX15, AURKB, BCL2, EGFR, ESR1, FABP3, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAOB, MET, MMP12, MMP9, NR1H4, PDE5A, PIK3CA, PIK3CB, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, THRA, THRB, TNKS, TNKS2, XDH 5.51053
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TBXAS1 5.51053
[BP] GO:2000147 positive regulation of cell motility ADRA2A, BCL2, EGFR, F10, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK 5.46051
[BP] GO:0051272 positive regulation of cellular component movement ADRA2A, BCL2, EGFR, F10, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK 5.31495
[BP] GO:0065007 biological regulation ABCB1, ACHE, ADORA3, ADRA2A, ADRA2C, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, GPR35, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPRS, RORC, SMAD3, SRC, TEK, THRA, THRB, TNKS, TNKS2, TOP1, XDH 5.28686
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, HTR1B, HTR1D, KDR, MAOB, SRC 5.23391
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, HSD11B2, HTR1B, MAOB, PTGS2, SRC 5.21646
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TBXAS1 5.21646
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CSNK2A1, EGFR, FLT3, HTR2B, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIM1, SRC, TEK, TNKS, TOP1 5.20172
[BP] GO:0009893 positive regulation of metabolic process ADRA2A, ADRA2C, ALOX15, AURKB, BCL2, CSNK2A1, EGFR, ESR1, FABP3, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAOB, MET, MMP12, MMP9, NR1H4, PDE5A, PIK3CA, PIK3CB, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, THRA, THRB, TNKS, TNKS2, XDH 5.1992
[BP] GO:0001932 regulation of protein phosphorylation ADRA2A, ADRA2C, ALOX15, BCL2, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, SRC, TEK, XDH 5.17584
[BP] GO:0040017 positive regulation of locomotion ADRA2A, BCL2, EGFR, F10, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK 5.15355
[BP] GO:0042325 regulation of phosphorylation ADRA2A, ADRA2C, ALOX15, BCL2, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MMP9, PDE5A, PIK3CA, PIK3CB, PPARA, PTGS2, SRC, TEK, XDH 5.14511
[BP] GO:0043405 regulation of MAP kinase activity ADRA2A, DUSP3, EGFR, FLT3, HTR2A, HTR2B, IGF1R, INSR, KIT, PDE5A, PIK3CB, SRC 5.13308
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, EGFR, MMP2, MMP9, TEK, THRA 5.11594
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, HTR2B, IGF1R, KDR, MMP9, NR1H4, PIK3CA, PIM1, PTGS2, SMAD3, SRC, TEK 5.09405
[BP] GO:0050790 regulation of catalytic activity ADORA3, ADRA2A, ADRA2C, AURKB, BCL2, CNR1, CNR2, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KIT, MMP9, NUAK1, PDE5A, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, TNKS, XDH 5.0869
[BP] GO:0010648 negative regulation of cell communication ACHE, ADRA2A, ADRA2C, BCL2, CNR2, DUSP3, EGFR, ESR1, GPR35, HSPA1A, HTR1B, HTR2A, IGF1R, MET, MMP12, MMP9, NR1H4, PTGS2, PTPRS, SMAD3, SRC, XDH 5.0869
[BP] GO:0023057 negative regulation of signaling ACHE, ADRA2A, ADRA2C, BCL2, CNR2, DUSP3, EGFR, ESR1, GPR35, HSPA1A, HTR1B, HTR2A, IGF1R, MET, MMP12, MMP9, NR1H4, PTGS2, PTPRS, SMAD3, SRC, XDH 5.06585
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, SRC, TEK 5.06184
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, EGFR, FLT3, HSD11B2, HTR1B, MAOB, PTGS2, SRC 5.04566
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA2A, ADRA2C, AXL, BCL2, CA2, CNR1, CYP1B1, EGFR, HCAR2, HSPA1A, HTR2A, HTR2B, KDR, KIT, MET, MMP12, MMP9, NR1H4, PDE5A, PIM1, PTGS2, SMAD3, SRC, TEK 5.01388
[BP] GO:0030334 regulation of cell migration ADORA3, ADRA2A, BCL2, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK 4.99803
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, EGFR, ESR1, HTR7, KIT, PPARA, RORC, SRC, TOP1 4.99803
[BP] GO:1903522 None ADORA3, ADRA2A, ADRA2C, CHRM1, CHRM2, EGFR, HTR2A, PDE5A, PTGS2, THRA, THRB 4.98519
[BP] GO:1903530 regulation of secretion by cell ACHE, ADRA2A, ADRA2C, CNR1, CYP19A1, EGFR, HCAR2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MAOB, MMP12, NR1H4, SRC 4.97887
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADRA2A, ADRA2C, ALOX15, AURKB, BCL2, CSNK2A1, EGFR, ESR1, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NR1H4, PDE5A, PIK3CA, PIK3CB, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, THRA, THRB, TNKS, TNKS2, XDH 4.97677
[BP] GO:0008152 metabolic process ACHE, AKR1B1, ALOX15, ALOX5, ALPL, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B1, HSPA1A, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR1H4, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPRS, RORC, SMAD3, SRC, TBXAS1, TEK, THRA, THRB, TNKS, TNKS2, TOP1, XDH 4.94063
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, ALOX15, ALOX5, ALPL, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSPA1A, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAOB, MET, MMP1, MMP2, NQO2, NR1H4, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPRS, RORC, SMAD3, SRC, TBXAS1, TEK, THRA, THRB, TNKS, TNKS2, TOP1, XDH 4.92903
[BP] GO:0007268 None CHRM1, CHRM2, CHRM4, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 4.90162
[BP] GO:0098916 None CHRM1, CHRM2, CHRM4, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 4.90162
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA3, ADRA2A, ADRA2C, AURKB, BCL2, CNR1, CNR2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, FABP4, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KIT, MET, MMP9, NR1H4, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, SMAD3, SRC, TEK, TNKS, XDH 4.85302
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGS1, PTGS2, TBXAS1 4.84694
[BP] GO:0055114 oxidation-reduction process AKR1B1, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, HSD11B1, HSD11B2, HSD17B1, MAOB, NQO2, PTGS1, PTGS2, TBXAS1, XDH 4.84423
[BP] GO:0009628 response to abiotic stimulus AKR1B1, AURKB, BCL2, CA2, CYP1A1, EGFR, HSD11B2, HSPA1A, HTR1B, HTR2A, HTR2B, KIT, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, THRA 4.82102
[BP] GO:0090066 None ADRA2A, ADRA2C, ALOX15, CHRM1, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 4.81759
[BP] GO:0080134 regulation of response to stress ABCB1, ADRA2A, CNR1, CNR2, CYP19A1, DUSP3, EGFR, ESR1, FABP4, HSPA1A, IGF1R, MET, MMP12, MMP2, NR1H4, NUAK1, PPARA, PTGS2, PTPRS, SMAD3, SRC, TEK, XDH 4.79704
[BP] GO:0019371 None CBR1, PTGS1, PTGS2, TBXAS1 4.79234
[BP] GO:0007610 None BCL2, CNR1, EGFR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, INSR, KIT, PPARA, PTGS2, THRA, THRB 4.702
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1 4.66552
[BP] GO:2000145 regulation of cell motility ADORA3, ADRA2A, BCL2, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK 4.65916
[BP] GO:0051247 positive regulation of protein metabolic process ADRA2A, ADRA2C, ALOX15, BCL2, CSNK2A1, EGFR, ESR1, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, XDH 4.63955
[BP] GO:0008202 steroid metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, NR1H4 4.62553
[BP] GO:0051046 None ACHE, ADRA2A, ADRA2C, CNR1, CYP19A1, EGFR, HCAR2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MAOB, MMP12, NR1H4, SRC 4.60921
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CSNK2A1, EGFR, FLT3, HTR2B, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TNKS, TOP1 4.59891
[BP] GO:0010038 response to metal ion ALOX15, BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, KIT, MAOB, MMP9, PTGS2 4.56529
[BP] GO:0031399 regulation of protein modification process ADRA2A, ADRA2C, ALOX15, BCL2, DUSP3, EGFR, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PDE5A, PIK3CA, PIK3CB, PTGS2, SRC, TEK, XDH 4.54745
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRA2A, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, DUSP3, ESR1, FABP4, GPR35, IGF1R, MET, MMP9, NR1H4, PIM1, PPARA, PTGS2, SRC, TNKS 4.52412
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 4.50151
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADRA2A, ADRA2C, ALOX15, BCL2, EGFR, ESR1, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, XDH 4.48493
[BP] GO:0019229 None ADRA2A, ADRA2C, CHRM1, EGFR, HTR2A, PTGS2 4.44766
[BP] GO:0032845 None ADRA2A, BCL2, HTR2A, HTR2B, HTR2C, SRC, TNKS, TNKS2 4.44697
[BP] GO:0032228 regulation of synaptic transmission, GABAergic CA2, CA7, CNR1, CNR2, HTR1B 4.44227
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, HTR1B, IGF1R, INSR, KDR, KIT, MMP2, MMP9, NR1H4, NUAK1, PIK3CA, PTGS2, RORC, SMAD3, SRC 4.44197
[BP] GO:0010243 response to organonitrogen compound AKR1B1, CNR1, CNR2, EGFR, FABP3, FLT3, HSD11B2, HTR1B, IGF1R, INSR, MMP2, NR1H4, PPARA, PTGS2, SRC, TEK 4.42944
[BP] GO:0009895 negative regulation of catabolic process ADRA2A, BCL2, CNR1, EGFR, HCAR2, HTR2B, MET, PIK3CA, PPARA, SMAD3 4.41789
[BP] GO:0046883 regulation of hormone secretion ADRA2A, ADRA2C, CNR1, CYP19A1, EGFR, HCAR2, HTR1A, HTR2A, HTR2C, NR1H4 4.41789
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CHRM1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, FLT3, HSD11B1, HTR5A, INSR, KDR, KIT, MAOB, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPRS, RORC, SMAD3, SRC, TEK, THRA 4.41639
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.40896
[BP] GO:0043406 positive regulation of MAP kinase activity ADRA2A, EGFR, FLT3, HTR2A, HTR2B, INSR, KIT, PDE5A, PIK3CB, SRC 4.40896
[BP] GO:0050789 regulation of biological process ABCB1, ACHE, ADORA3, ADRA2A, ADRA2C, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, GPR35, HCAR2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPRS, RORC, SMAD3, SRC, TEK, THRA, THRB, TNKS, TNKS2, TOP1, XDH 4.40132
[BP] GO:0010863 positive regulation of phospholipase C activity EGFR, ESR1, HTR2A, HTR2B, KIT 4.39123
[BP] GO:0007154 None ADRA2C, AXL, BCL2, CHRM1, CHRM2, CHRM4, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PTGS2, TEK 4.38831
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, SMAD3, SRC, TEK 4.37123
[BP] GO:0051051 negative regulation of transport ADRA2A, ADRA2C, BCL2, CNR1, GPR35, HSPA1A, HTR1B, HTR2A, MAOB, MMP9, NR1H4, PTGS2, THRA 4.36478
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, EGFR, F10, FLT3, IGF1R, INSR, KDR, KIT, MET, NR1H4, SRC, TEK, TNKS, TOP1 4.33199
[BP] GO:0031401 positive regulation of protein modification process ADRA2A, ADRA2C, ALOX15, BCL2, EGFR, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, SRC, TEK, XDH 4.32814
[BP] GO:0046889 None FABP3, HTR2A, HTR2B, HTR2C, NR1H4, PTGS2 4.31995
[BP] GO:0050795 None CNR1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B 4.31995
[BP] GO:0051347 positive regulation of transferase activity ADRA2A, ADRA2C, AURKB, EGFR, FLT3, HTR2A, HTR2B, INSR, KIT, PDE5A, PIK3CA, PIK3CB, SRC, TEK, TNKS 4.29827
[BP] GO:0006940 None ADRA2A, ADRA2C, CHRM1, CHRM2, KIT, PTGS2 4.28338
[BP] GO:0031347 regulation of defense response CNR1, CNR2, CYP19A1, EGFR, ESR1, FABP4, HSPA1A, MMP12, MMP2, NR1H4, PPARA, PTGS2, PTPRS, SMAD3, SRC, TEK 4.26635
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, MAOB, NR1H4, PTGS2, SRC 4.24759
[BP] GO:0051270 regulation of cellular component movement ADORA3, ADRA2A, BCL2, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK 4.24263
[BP] GO:1900274 regulation of phospholipase C activity EGFR, ESR1, HTR2A, HTR2B, KIT 4.22454
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA3, ADRA2A, ADRA2C, AKR1B1, ALOX15, ALOX5, ALPL, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, FUT7, GPR35, HCAR2, HSD17B1, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR1H4, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPRS, RORC, SMAD3, SRC, TBXAS1, TEK, THRA, THRB, TNKS, TNKS2, TOP1, TUBB3, XDH 4.20514
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, HTR2A, INSR, MET, SMAD3, SRC 4.19381
[BP] GO:0043269 regulation of ion transport ABCB1, ADRA2A, BCL2, CA2, CA7, CHRM1, CNR1, GPR35, HTR1A, HTR1B, HTR2A, MAOB, MMP9, PTGS2 4.17196
[BP] GO:0051338 regulation of transferase activity ADRA2A, ADRA2C, AURKB, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, KIT, PDE5A, PIK3CA, PIK3CB, SRC, TEK, TNKS 4.16099
[BP] GO:0048585 negative regulation of response to stimulus ADRA2A, ALOX15, BCL2, CNR1, CNR2, CYP19A1, DUSP3, EGFR, ESR1, HSPA1A, IGF1R, MET, MMP12, MMP9, NR1H4, PPARA, PTGS2, PTPRS, SMAD3, SRC, TEK, XDH 4.15829
[BP] GO:0009894 regulation of catabolic process ADRA2A, BCL2, CNR1, CSNK2A1, EGFR, HCAR2, HSPA1A, HTR2A, HTR2B, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, SMAD3, THRA 4.11834
[BP] GO:0090087 None ACHE, ADRA2A, ADRA2C, CA2, CHRM1, CNR1, EGFR, HCAR2, HTR2B, HTR2C, MMP12, NR1H4, PTGS2, SMAD3, SRC, THRA 4.10805
[BP] GO:0050794 regulation of cellular process ACHE, ADORA3, ADRA2A, ADRA2C, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, GPR35, HCAR2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPRS, RORC, SMAD3, SRC, TEK, THRA, THRB, TNKS, TNKS2, XDH 4.08501
[BP] GO:0007197 None CHRM1, CHRM2, CHRM4 4.07112
[BP] GO:0010513 None HTR2A, HTR2B, HTR2C 4.07112
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA3, ADRA2A, ADRA2C, ALOX15, AURKB, BCL2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, HCAR2, HSPA1A, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAOB, MET, MMP12, MMP9, NR1H4, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, THRA, THRB, TNKS, TNKS2, TOP1, XDH 4.07112
[BP] GO:1901698 response to nitrogen compound AKR1B1, CNR1, CNR2, EGFR, FABP3, FLT3, HSD11B2, HTR1B, IGF1R, INSR, MMP2, NR1H4, PPARA, PTGS2, SRC, TEK 4.05616
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AURKB, AXL, BCL2, CHRM1, CSNK2A1, CYP1A1, CYP1A2, DAO, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, HSPA1A, HTR1A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NUAK1, PDE5A, PIK3CA, PIM1, PPARA, PTGS2, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, XDH 4.05137
[BP] GO:0007267 None ADRA2C, CHRM1, CHRM2, CHRM4, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, TEK 4.04566
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, MAOB, NR1H4, PTGS2, SRC 4.02076
[BP] GO:0016477 cell migration AXL, CNR2, CYP1B1, EGFR, FUT7, HTR2B, HTR6, KDR, KIT, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC, TEK 3.9673
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, CA2, CA7, CNR1, CNR2, EGFR, HTR1B, HTR2A, KIT, PTGS2 3.9603
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, CA2, CA7, CNR1, CNR2, EGFR, HTR1B, HTR2A, KIT, PTGS2 3.9603
[BP] GO:0033674 positive regulation of kinase activity ADRA2A, ADRA2C, EGFR, FLT3, HTR2A, HTR2B, INSR, KIT, PDE5A, PIK3CA, PIK3CB, SRC, TEK 3.94091
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, AURKB, AXL, BCL2, CNR1, ESR1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 3.94068
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, HTR1B, MMP2, MMP9, PTGS2 3.92769
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, PIK3CA, PIK3CB, PTGS1, PTGS2 3.90233
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, NR1H4, PIM1, PPARA, RORC, SRC, THRA, THRB 3.90002
[BP] GO:0009892 negative regulation of metabolic process ADRA2A, AURKB, BCL2, CNR1, CNR2, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, HCAR2, HSPA1A, HTR1B, HTR1E, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, NR1H4, PIK3CA, PPARA, PTGS2, RORC, SMAD3, SRC, THRA, THRB, TNKS, TNKS2, XDH 3.8889
[BP] GO:0043549 regulation of kinase activity ADRA2A, ADRA2C, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, KIT, PDE5A, PIK3CA, PIK3CB, SRC, TEK 3.8889
[BP] GO:0050727 regulation of inflammatory response CNR1, CNR2, CYP19A1, EGFR, ESR1, FABP4, NR1H4, PPARA, PTGS2, SMAD3, TEK 3.84723
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, ADRA2A, AXL, BCL2, CA2, CHRM1, CYP19A1, EGFR, HCAR2, HTR2B, INSR, MMP12, NR1H4, PTGS2, SMAD3, SRC 3.84723
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, EGFR, PPARA, SMAD3 3.83489
[BP] GO:0007207 None CHRM1, CHRM2, CHRM4 3.80296
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, NR1H4, PPARA, PTGS1, PTGS2, TBXAS1 3.77975
[BP] GO:0050801 ion homeostasis BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, GPR35, HTR2A, HTR2B, HTR2C, NR1H4, PIK3CB, SMAD3 3.73664
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, NR1H4, PPARA, RORC, SRC, THRA, THRB 3.71549
[BP] GO:0050433 None ADRA2A, ADRA2C, CNR1, HTR1B, HTR2A 3.69605
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.69605
[BP] GO:0032101 regulation of response to external stimulus CNR1, CNR2, CYP19A1, EGFR, ESR1, FABP4, KDR, MET, MMP12, NR1H4, PPARA, PTGS2, PTPRS, SMAD3, TEK 3.64497
[BP] GO:0050793 regulation of developmental process ADRA2C, AXL, BCL2, CA2, CNR1, CYP1B1, EGFR, ESR1, HTR2A, HTR2C, INSR, KDR, KIT, NR1H4, NUAK1, PDE5A, PIK3CA, PIM1, PPARA, PTGS2, PTPRS, RORC, SMAD3, SRC, TEK, THRA, TNKS2, XDH 3.64207
[BP] GO:0071495 cellular response to endogenous stimulus ADRA2A, AKR1B1, EGFR, ESR1, FLT3, HTR1B, IGF1R, INSR, KIT, MMP2, NR1H4, PTGS2, SMAD3, SRC 3.64207
[BP] GO:0044093 positive regulation of molecular function ABCB1, ADRA2A, ADRA2C, AURKB, BCL2, EGFR, ESR1, FLT3, HSPA1A, HTR2A, HTR2B, INSR, KIT, MET, MMP9, PDE5A, PIK3CA, PIK3CB, SMAD3, SRC, TEK, TNKS, XDH 3.63117
[BP] GO:0010518 positive regulation of phospholipase activity EGFR, ESR1, HTR2A, HTR2B, KIT 3.61282
[BP] GO:0045859 regulation of protein kinase activity ADRA2A, ADRA2C, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, KIT, PDE5A, PIK3CA, PIK3CB, SRC 3.61266
[BP] GO:0001666 response to hypoxia BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 3.6116
[BP] GO:0014062 None HTR1A, HTR1B, MAOB 3.58741
[BP] GO:0010511 None HTR2A, HTR2B, HTR2C 3.58741
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADRA2A, DUSP3, EGFR, FLT3, HTR2A, HTR2B, IGF1R, INSR, KIT, PDE5A, PIK3CB, SRC 3.58687
[BP] GO:0080090 regulation of primary metabolic process ADORA3, ADRA2A, ADRA2C, ALOX15, AURKB, BCL2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, HCAR2, HSPA1A, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAOB, MET, MMP12, MMP9, NR1H4, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, THRA, THRB, TNKS, TNKS2, XDH 3.57753
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, NR1H4, PPARA 3.57059
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, EGFR, HTR2A, HTR2B, HTR2C, KDR, SRC, TEK 3.56033
[BP] GO:0023052 None ADRA2C, CHRM1, CHRM2, CHRM4, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, TEK 3.55526
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, EGFR, FLT3, HSD11B2, MAOB, PTGS2 3.55376
[BP] GO:0019748 secondary metabolic process AKR1B1, BCL2, CYP1A1, CYP1A2, CYP1B1 3.54743
[BP] GO:0040011 locomotion AXL, CNR2, CYP1B1, EGFR, FUT7, HTR2B, HTR6, KDR, KIT, MET, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC, TEK 3.53171
[BP] GO:0036293 response to decreased oxygen levels BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 3.52572
[BP] GO:0051094 positive regulation of developmental process ADRA2C, AXL, BCL2, CA2, CNR1, CYP1B1, HTR2A, HTR2C, INSR, KDR, KIT, NR1H4, PDE5A, PIM1, PTGS2, SMAD3, SRC, TEK, THRA 3.52197
[BP] GO:0006979 response to oxidative stress AKR1B1, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, PTGS1, PTGS2, SRC 3.5166
[BP] GO:0050994 None ADRA2A, CNR1, HCAR2, PPARA, THRA 3.51271
[BP] GO:0045860 positive regulation of protein kinase activity ADRA2A, ADRA2C, EGFR, FLT3, HTR2A, HTR2B, INSR, KIT, PDE5A, PIK3CA, PIK3CB, SRC 3.5107
[BP] GO:0048870 cell motility AXL, CNR2, CYP1B1, EGFR, FUT7, HTR2B, HTR6, KDR, KIT, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC, TEK 3.50846
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1, MAOB 3.50582
[BP] GO:0002682 regulation of immune system process ALOX15, AXL, BCL2, CA2, CNR1, CNR2, CYP19A1, DUSP3, ESR1, HCAR2, HSPA1A, KIT, MMP12, MMP2, NR1H4, PDE5A, PIK3CA, PIK3CB, PTPRS, SMAD3, SRC 3.46414
[BP] GO:0006950 response to stress ACHE, ADORA3, AKR1B1, ALOX15, AXL, BCL2, CA2, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, EGFR, HSD11B2, HSPA1A, HTR1A, HTR2C, KIT, MMP2, MMP9, NR1H4, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SMAD3, SRC, TEK, THRA 3.45781
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, BCL2, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 3.45554
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, DUSP3, EGFR, HTR2A, HTR2B, HTR2C, KDR, SRC, TEK 3.44939
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADRA2A, EGFR, FLT3, HTR2A, HTR2B, INSR, KIT, PDE5A, PIK3CB, SRC 3.44156
[BP] GO:0070201 None ACHE, ADRA2A, ADRA2C, BCL2, CHRM1, CNR1, EGFR, HCAR2, HTR2B, MMP12, NR1H4, PTGS2, SMAD3, SRC, THRA 3.42566
[BP] GO:0050665 hydrogen peroxide biosynthetic process CYP1A1, CYP1A2, MAOB 3.41962
[BP] GO:2000021 regulation of ion homeostasis BCL2, CA2, CA7, HTR2A, HTR2B, HTR2C, KDR, SRC 3.41455
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 3.40031
[BP] GO:0043085 positive regulation of catalytic activity ADRA2A, ADRA2C, AURKB, BCL2, EGFR, ESR1, FLT3, HSPA1A, HTR2A, HTR2B, INSR, KIT, PDE5A, PIK3CA, PIK3CB, SMAD3, SRC, TEK, TNKS, XDH 3.38065
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.29376
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.29376
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.29376
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.29376
[BP] GO:0002791 None ACHE, ADRA2A, ADRA2C, CNR1, EGFR, HCAR2, HTR2B, HTR2C, MMP12, NR1H4, SRC 3.29376
[BP] GO:0001775 cell activation ADRA2A, ADRA2C, ALOX5, AXL, BCL2, EGFR, FLT3, FUT7, HSPA1A, KIT, MMP9, PIK3CA, PIK3CB, RORC, SMAD3, SRC 3.29184
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR, MAOB 3.27653
[BP] GO:0010517 regulation of phospholipase activity EGFR, ESR1, HTR2A, HTR2B, KIT 3.27653
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic CNR1, EGFR, HTR1B, HTR2A, PTGS2 3.27653
[BP] GO:0070482 response to oxygen levels BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 3.26682
[BP] GO:0033032 regulation of myeloid cell apoptotic process BCL2, HCAR2, PIK3CB, THRA 3.26287
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, KDR, PIK3CB, SMAD3, SRC, TEK 3.25663
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CYP1B1, EGFR, ESR1, IGF1R, INSR, MMP2, MMP9, NR1H4, PIK3CA, PTGS2, RORC, SRC 3.22637
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1 3.21296
[BP] GO:0048015 phosphatidylinositol-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 3.21296
[BP] GO:0006937 None ADRA2A, ADRA2C, CHRM1, CHRM2, KIT, PDE5A, PTGS2 3.19094
[BP] GO:0060193 positive regulation of lipase activity EGFR, ESR1, HTR2A, HTR2B, KIT 3.18207
[BP] GO:0090257 None ADRA2A, ADRA2C, CHRM1, CHRM2, KIT, PDE5A, PTGS2, SMAD3 3.15763
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC, TEK 3.15552
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR, MAOB 3.15552
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1 3.15552
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 3.15552
[BP] GO:0022414 reproductive process ADRA2C, AKR1B1, ALPL, AXL, BCL2, CNR1, CYP19A1, CYP1A1, EGFR, ESR1, HSD11B2, INSR, KIT, MMP2, MMP9, PTGS2, SRC, THRA, THRB 3.13976
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.13976
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.13976
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, CNR2, HTR1B, HTR2A, PTGS2 3.12981
[BP] GO:0048017 inositol lipid-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 3.12981
[BP] GO:0030155 regulation of cell adhesion ALOX15, BCL2, CYP1B1, DUSP3, KDR, NUAK1, PDE5A, PIK3CA, PIK3CB, PPARA, SMAD3, SRC, TEK 3.12193
[BP] GO:0030168 platelet activation ADRA2A, ADRA2C, AXL, PIK3CA, PIK3CB, SRC 3.11888
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, NR1H4, PPARA, RORC, SRC, THRA, THRB 3.10835
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA3, ADRA2A, ADRA2C, ALOX15, AURKB, BCL2, CA9, CNR1, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, HSPA1A, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAOB, MET, MMP12, MMP9, NR1H4, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, THRA, THRB, TNKS, TNKS2, XDH 3.10596
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, INSR, PTGS2, SMAD3, XDH 3.07728
[BP] GO:0051223 None ACHE, ADRA2A, ADRA2C, CHRM1, CNR1, EGFR, HCAR2, HTR2B, MMP12, NR1H4, PTGS2, SMAD3, SRC, THRA 3.07296
[BP] GO:0031348 negative regulation of defense response CNR2, CYP19A1, MMP12, NR1H4, PPARA, SMAD3, TEK 3.04791
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, NQO2, PTGS1, RORC 3.03897
[BP] GO:0006928 movement of cell or subcellular component ADRA2A, AXL, CNR2, CYP1B1, EGFR, FUT7, HTR2B, HTR6, KDR, KIT, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TEK, TUBB3 3.03587
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 3.03526
[BP] GO:0050728 negative regulation of inflammatory response CNR2, CYP19A1, NR1H4, PPARA, SMAD3, TEK 3.02204
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 3.02204
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, KIT, SRC, TEK 3.01651
[BP] GO:0045907 None ADRA2C, EGFR, HTR2A, PTGS2 3.01651
[BP] GO:0031324 negative regulation of cellular metabolic process ADRA2A, AURKB, BCL2, CNR1, CSNK2A1, DUSP3, ESR1, FABP4, HSPA1A, HTR1B, HTR1E, HTR2B, IGF1R, MET, MMP12, MMP9, NR1H4, PIK3CA, PPARA, PTGS2, RORC, SMAD3, SRC, THRA, THRB, TNKS, TNKS2, XDH 3.01651
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC 3.01141
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, PIK3CA, SMAD3, THRA 3.00858
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, ALOX15, ALOX5, ALPL, AURKB, AXL, BCL2, CBR1, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B1, HSPA1A, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPRS, RORC, SMAD3, SRC, TBXAS1, TEK, THRA, THRB, TNKS, TNKS2, TOP1, XDH 3.00704
[BP] GO:0035556 intracellular signal transduction ADRA2A, ADRA2C, AKR1B1, AXL, BCL2, CYP1B1, EGFR, HTR2A, HTR2B, HTR5A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, SRC, TEK 2.99397
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, EGFR, FABP3, FABP4, KIT, MET, PIK3CA, PIK3CB 2.99215
[BP] GO:0032880 regulation of protein localization ACHE, ADRA2A, ADRA2C, BCL2, CHRM1, CNR1, CSNK2A1, EGFR, HCAR2, HTR2B, MMP12, NR1H4, PTGS2, SMAD3, SRC, THRA 2.98102
[BP] GO:0032148 None ADRA2A, ADRA2C, INSR, SRC 2.97358
[BP] GO:0009891 positive regulation of biosynthetic process AURKB, EGFR, ESR1, FABP3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP12, NR1H4, PPARA, PTGS2, RORC, SMAD3, SRC, THRA, THRB, TNKS, TNKS2 2.96363
[BP] GO:0043207 response to external biotic stimulus ALPL, AXL, BCL2, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, MAOB, MMP12, NR1H4, PTGS2, SMAD3, SRC 2.9411
[BP] GO:0032268 regulation of cellular protein metabolic process ADRA2A, ADRA2C, ALOX15, BCL2, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PDE5A, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, XDH 2.9411
[BP] GO:0045759 None CNR1, CNR2, GPR35 2.91808
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 2.91597
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, ALOX15, BCL2, CYP19A1, CYP1A1, CYP1B1, DAO, HTR1A, MAOB, NR1H4 2.91064
[BP] GO:0008050 None THRA, THRB 2.90935
[BP] GO:0007208 None HTR2A, HTR2C 2.90935
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, EGFR, HTR1A, INSR, MAOB, PTGS2, SMAD3 2.8685
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, BCL2, CHRM1, EGFR, HCAR2, HTR2B, MMP12, NR1H4, PTGS2, SMAD3, SRC 2.85029
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC, TEK 2.84995
[BP] GO:0046456 icosanoid biosynthetic process ALOX15, ALOX5, PTGS1, PTGS2 2.84465
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DUSP3, ESR1, HSPA1A, IGF1R, MET, MMP9, NR1H4, PTGS2, SRC, XDH 2.8383
[BP] GO:0050708 None ACHE, ADRA2A, ADRA2C, CNR1, EGFR, HCAR2, HTR2B, MMP12, NR1H4, SRC 2.83727
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, BCL2, KDR, PIK3CB, SMAD3, SRC, TEK 2.82673
[BP] GO:0033604 None ADRA2A, ADRA2C, CNR1 2.82541
[BP] GO:0051952 None ADRA2A, ADRA2C, CNR1, HTR1B, HTR2A 2.82131
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, HTR1B, MMP2, MMP9, PTGS2 2.79969
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA3, ADRA2A, ADRA2C, ALOX15, AURKB, BCL2, CA9, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, HSPA1A, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAOB, MET, MMP12, MMP9, NR1H4, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, THRA, THRB, TNKS, TNKS2, XDH 2.79672
[BP] GO:0018958 None AKR1B1, BCL2, DAO, HTR1A, MAOB 2.76992
[BP] GO:0009607 response to biotic stimulus ALPL, AXL, BCL2, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, MAOB, MMP12, NR1H4, PTGS2, SMAD3, SRC 2.7654
[BP] GO:0007166 cell surface receptor signaling pathway ADORA3, AXL, BCL2, CA1, CHRM4, CSNK2A1, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, NR1H4, PIK3CA, PIK3CB, SMAD3, SRC, TEK, TNKS, TNKS2 2.75847
[BP] GO:0006954 inflammatory response ADORA3, ALOX15, AXL, CNR2, KIT, NR1H4, PIK3CA, PIK3CB, PTGS1, PTGS2 2.75294
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 2.74952
[BP] GO:1901652 response to peptide AKR1B1, FABP3, HSD11B2, IGF1R, INSR, PPARA, PTGS2, SRC, TEK 2.73434
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.73338
[BP] GO:0050900 leukocyte migration CNR2, FUT7, KIT, MMP1, MMP9, PIK3CA, PIK3CB, SRC, TEK 2.71832
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, PTGS2, RORC, SRC 2.71832
[BP] GO:0050890 None CHRM1, CNR1, EGFR, HTR2A, INSR, KIT, PTGS2, THRA 2.69311
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, DAO, FABP3, NR1H4, PIM1, PPARA, PTGS1, PTGS2, TBXAS1 2.68866
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, PTGS2, SMAD3 2.68866
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.68866
[BP] GO:0098771 inorganic ion homeostasis BCL2, CA12, CA2, CA7, EGFR, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3 2.68172
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, NR1H4, PPARA 2.65511
[BP] GO:0048609 multicellular organismal reproductive process AKR1B1, AXL, CNR1, CYP1A1, EGFR, ESR1, KIT, PTGS2, SRC, THRA, THRB 2.62137
[BP] GO:0055082 cellular chemical homeostasis BCL2, CA2, CA7, ESR1, GPR35, HTR2A, HTR2B, HTR2C, NR1H4, PIK3CA, PIK3CB, SMAD3 2.61583
[BP] GO:0043551 regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC, TEK 2.61341
[BP] GO:0060191 regulation of lipase activity EGFR, ESR1, HTR2A, HTR2B, KIT 2.61259
[BP] GO:0031328 positive regulation of cellular biosynthetic process AURKB, EGFR, ESR1, FABP3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, MET, MMP12, NR1H4, PPARA, PTGS2, RORC, SMAD3, SRC, THRA, THRB, TNKS, TNKS2 2.60902
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.59738
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, EGFR, HTR1B, KDR, PTGS2, SRC 2.59738
[BP] GO:0050999 None CNR1, CNR2, EGFR, HTR2B 2.58099
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.57611
[BP] GO:0007213 None CHRM1, CHRM2, CHRM4 2.57611
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.57611
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.57611
[BP] GO:0051704 multi-organism process ADRA2C, AXL, BCL2, CHRM2, CYP1A1, EGFR, HSD11B2, HSPA1A, HTR2A, INSR, KDR, MET, MMP1, MMP12, NR1H4, SMAD3, SRC, TOP1 2.55888
[BP] GO:0019637 organophosphate metabolic process ACHE, ALOX15, CSNK2A1, EGFR, HSPA1A, HTR2B, HTR2C, KIT, MET, PDE5A, PIK3CA, PIK3CB, PTGS2, XDH 2.55695
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, EGFR, IGF1R, INSR, SRC, TNKS, TNKS2 2.52716
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, PTGS2, SMAD3, XDH 2.51119
[BP] GO:0009605 response to external stimulus ALPL, AXL, BCL2, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, EGFR, HSD11B2, HTR2A, KIT, MAOB, MMP12, NR1H4, PTGS2, SMAD3, SRC 2.50348
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.50253
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.49904
[BP] GO:0006808 regulation of nitrogen utilization BCL2, NR1H4 2.49904
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, ALOX15, ALOX5, ALPL, AURKB, AXL, BCL2, CBR1, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B1, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPRS, RORC, SMAD3, SRC, TBXAS1, TEK, THRA, THRB, TNKS, TNKS2, TOP1, XDH 2.49904
[BP] GO:0008217 None CNR1, HSD11B2, PPARA, PTGS1, PTGS2, SMAD3 2.485
[BP] GO:0050776 regulation of immune response ALOX15, BCL2, CNR1, DUSP3, ESR1, HSPA1A, KIT, MMP12, MMP2, NR1H4, PIK3CA, PIK3CB, PTPRS, SMAD3, SRC 2.485
[BP] GO:0009266 None HSPA1A, HTR1B, HTR2A, HTR2B, PTGS2, THRA 2.47011
[BP] GO:0006939 None HTR1D, HTR2A, HTR2B, HTR7 2.45731
[BP] GO:0009056 catabolic process ACHE, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, FABP3, FABP4, FUT7, HSPA1A, MAOB, MMP1, MMP12, MMP2, MMP9, PDE5A, PIK3CB, SRC, XDH 2.45326
[BP] GO:0051222 positive regulation of protein transport ACHE, CHRM1, EGFR, HCAR2, HTR2B, MMP12, NR1H4, PTGS2, SMAD3, SRC 2.44148
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTGS2, SRC 2.41906
[BP] GO:0044089 positive regulation of cellular component biogenesis ALOX15, ESR1, HSPA1A, KDR, KIT, MET, MMP1, SMAD3, SRC, TEK 2.40821
[BP] GO:0014066 regulation of phosphatidylinositol 3-kinase signaling EGFR, FLT3, KDR, KIT, TEK 2.38005
[BP] GO:0051246 regulation of protein metabolic process ADRA2A, ADRA2C, ALOX15, BCL2, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PDE5A, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, XDH 2.38005
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, EGFR, HTR1B, IGF1R, INSR, MMP2, NR1H4, PTGS2, SRC 2.38005
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.37547
[BP] GO:0046854 phosphatidylinositol phosphorylation EGFR, KIT, MET, PIK3CA, PIK3CB 2.34356
[BP] GO:0009968 negative regulation of signal transduction ADRA2A, BCL2, DUSP3, EGFR, ESR1, HSPA1A, IGF1R, MET, MMP12, MMP9, NR1H4, PTGS2, PTPRS, SMAD3, SRC, XDH 2.34345
[BP] GO:0050730 None ADRA2A, ADRA2C, EGFR, FLT3, HTR2A, KIT, SRC 2.33881
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.33842
[BP] GO:0043550 regulation of lipid kinase activity FLT3, KIT, SRC, TEK 2.33842
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, NR1H4, PPARA, RORC, THRA, THRB 2.33648
[BP] GO:0032147 activation of protein kinase activity ADRA2A, ADRA2C, EGFR, INSR, KIT, PIK3CA, PIK3CB, SRC 2.32139
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.31053
[BP] GO:0022900 electron transport chain AKR1B1, CYP19A1, CYP1A2, MAOB, NQO2, XDH 2.31053
[BP] GO:1900542 None ADRA2A, HTR1B, HTR1E, HTR2A, INSR, PDE5A, PPARA 2.31053
[BP] GO:0002683 negative regulation of immune system process ALOX15, AXL, CNR1, CNR2, CYP19A1, DUSP3, MMP12, PDE5A, PTPRS 2.30378
[BP] GO:0050714 None ACHE, EGFR, HCAR2, HTR2B, MMP12, NR1H4, SRC 2.30182
[BP] GO:0007611 None CNR1, EGFR, HTR2A, INSR, KIT, PTGS2, THRA 2.30182
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, DAO, FABP3, NR1H4, PIM1, PPARA, PTGS1, PTGS2, TBXAS1 2.29486
[BP] GO:0051128 regulation of cellular component organization ALOX15, AURKB, AXL, BCL2, CNR1, CSNK2A1, EGFR, ESR1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP9, PIK3CB, PTPRS, SMAD3, SRC, TEK, THRA, TNKS, TNKS2 2.28677
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.28522
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.28522
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.26211
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.26211
[BP] GO:0006464 cellular protein modification process ALPL, AURKB, AXL, BCL2, CHRM1, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, KIT, MET, NR1H4, NUAK1, PIK3CA, PIM1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1 2.26211
[BP] GO:0036211 protein modification process ALPL, AURKB, AXL, BCL2, CHRM1, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, KIT, MET, NR1H4, NUAK1, PIK3CA, PIM1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1 2.26211
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, KDR, MMP2, NR1H4, PTGS2, SRC 2.25992
[BP] GO:0032768 None CNR1, CNR2, EGFR, HTR2B 2.25947
[BP] GO:0046890 None FABP3, HTR2A, HTR2B, HTR2C, NR1H4, PTGS2 2.25105
[BP] GO:0006140 None ADRA2A, HTR1B, HTR1E, HTR2A, INSR, PDE5A, PPARA 2.25018
[BP] GO:0035625 None ADRA2A, ADRA2C 2.25018
[BP] GO:0032811 None ADRA2A, ADRA2C 2.25018
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.25018
[BP] GO:0070213 None TNKS, TNKS2 2.25018
[BP] GO:0038171 None CNR1, CNR2 2.25018
[BP] GO:0014063 None HTR1B, MAOB 2.25018
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.25018
[BP] GO:0014827 None HTR1D, HTR2B 2.25018
[BP] GO:0001817 regulation of cytokine production ADRA2A, AXL, CYP1B1, HSPA1A, HTR2B, MMP12, NR1H4, PTGS2, PTPRS, SMAD3, SRC 2.24545
[BP] GO:0044267 cellular protein metabolic process ALPL, AURKB, AXL, BCL2, CHRM1, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP2, NR1H4, NUAK1, PIK3CA, PIM1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1 2.24501
[BP] GO:0046686 response to cadmium ion CYP1A2, EGFR, KIT, MMP9 2.24054
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, DAO, FABP3, NR1H4, PIM1, PPARA, PTGS1, PTGS2, TBXAS1 2.23486
[BP] GO:0031349 positive regulation of defense response CNR1, EGFR, FABP4, HSPA1A, MMP12, MMP2, NR1H4, PTGS2, SRC 2.23469
[BP] GO:0072507 divalent inorganic cation homeostasis BCL2, EGFR, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3 2.23469
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation HTR1B, MMP2, MMP9 2.2201
[BP] GO:0050995 None ADRA2A, CNR1, HCAR2 2.2201
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.21752
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.21752
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.20609
[BP] GO:0008406 gonad development BCL2, CYP19A1, ESR1, INSR, KIT 2.20609
[BP] GO:0055080 cation homeostasis BCL2, CA2, CA7, EGFR, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3 2.19601
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADRA2A, ADRA2C, FLT3, HTR2A, KIT, SRC 2.18862
[BP] GO:0051953 None ADRA2A, ADRA2C, CNR1 2.17069
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.17069
[BP] GO:0095500 None CHRM1, CHRM2, CHRM4 2.17069
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.17069
[BP] GO:1903831 None CHRM1, CHRM2, CHRM4 2.17069
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, CBR1, CYP1A1, CYP1A2, CYP1B1, DAO, EGFR, HSPA1A, MAOB 2.17069
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, EGFR, HTR1B, IGF1R, INSR, MMP2, NR1H4, PTGS2, SRC 2.17069
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.16943
[BP] GO:0019538 protein metabolic process ACHE, ALPL, AURKB, AXL, BCL2, CHRM1, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NUAK1, PIK3CA, PIM1, PPARA, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1 2.16832
[BP] GO:0006650 glycerophospholipid metabolic process ACHE, ALOX15, CSNK2A1, EGFR, KIT, MET, PIK3CA, PIK3CB 2.16492
[BP] GO:0046834 lipid phosphorylation EGFR, KIT, MET, PIK3CA, PIK3CB 2.16137
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CNR1, CYP1A1, EGFR, HSD11B2, PTGS2, SRC 2.14524
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.14524
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, EGFR, MAOB, SRC 2.13325
[BP] GO:0002793 None ACHE, EGFR, HCAR2, HTR2B, MMP12, NR1H4, SRC 2.1278
[BP] GO:0051894 None KDR, SMAD3, TEK 2.12723
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1 2.12723
[BP] GO:0007202 None EGFR, HTR2A, HTR2B 2.12723
[BP] GO:0032098 None HTR2C, HTR4, PPARA 2.12723
[BP] GO:0001525 angiogenesis CYP1B1, KDR, MMP2, PIK3CA, PIK3CB, PTGS2, TEK 2.12239
[BP] GO:0051098 regulation of binding AURKB, BCL2, MET, MMP9, PPARA, SMAD3, SRC, TNKS 2.11479
[BP] GO:0097164 None ACHE, AKR1B1, CSNK2A1, DAO, HTR1A, MAOB 2.08926
[BP] GO:0045932 None ADRA2C, PDE5A, PTGS2 2.07667
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, KIT, MMP9, RORC 2.0746
[BP] GO:1903531 None ADRA2A, ADRA2C, CNR1, HTR1B, MAOB, NR1H4 2.07144
[BP] GO:0035624 None ADRA2A, ADRA2C 2.07144
[BP] GO:0060509 None THRA, THRB 2.07144
[BP] GO:0071502 None HTR1B, HTR2B 2.07144
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.07144
[BP] GO:0014060 None ADRA2A, ADRA2C 2.07144
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.05463
[BP] GO:0008150 biological_process ABCB1, ACHE, ADORA3, ADRA2A, ADRA2C, AKR1B1, ALOX15, ALOX5, ALPL, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, FUT7, GPR35, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR1H4, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPRS, RORC, SMAD3, SRC, TBXAS1, TEK, THRA, THRB, TNKS, TNKS2, TOP1, TUBB3, XDH 2.05407
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.03791
[BP] GO:1903393 None KDR, SMAD3, TEK 2.03791
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.03582
[BP] GO:0051926 negative regulation of calcium ion transport ADRA2A, BCL2, GPR35, PTGS2 2.03582
[BP] GO:0045597 positive regulation of cell differentiation ADRA2C, AXL, BCL2, CA2, CNR1, HTR2A, HTR2C, KDR, KIT, PDE5A, PTGS2, SMAD3, THRA 2.03511
[BP] GO:0048729 tissue morphogenesis BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.03272
[BP] GO:0045598 None HTR2A, HTR2C, PTGS2, RORC, SMAD3 2.03272
[BP] GO:0030098 lymphocyte differentiation AXL, BCL2, FLT3, FUT7, KIT, RORC 2.03257
[BP] GO:1903532 None ACHE, CYP19A1, EGFR, HCAR2, HTR2B, MMP12, NR1H4, SRC 2.02635
[BP] GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling FLT3, KDR, KIT, TEK 2.01495
[BP] GO:0031329 regulation of cellular catabolic process ADRA2A, BCL2, CNR1, HSPA1A, HTR2A, HTR2B, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA 2.00543
[BP] GO:0048608 reproductive structure development AXL, BCL2, CYP19A1, ESR1, INSR, KIT, SRC 2.00543
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.00086
[BP] GO:0007271 None CHRM1, CHRM2, CHRM4 2.00086
[CC] GO:0031226 intrinsic component of plasma membrane ADORA3, ADRA2A, ADRA2C, AXL, CA4, CHRM1, CHRM2, CHRM4, CNR1, CNR2, F10, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PTPRS, TEK 9.25277
[CC] GO:0044459 plasma membrane part ABCB1, ADORA3, ADRA2A, ADRA2C, ALOX15, AXL, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DUSP3, EGFR, F10, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, PTGS2, PTPRS, SRC, TEK 8.65813
[CC] GO:0005887 integral component of plasma membrane ADORA3, ADRA2A, ADRA2C, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PTPRS, TEK 8.28007
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA3, ADRA2A, ADRA2C, ALOX15, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, EGFR, ESR1, F10, FLT3, GPR35, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTPRS, SMAD3, SRC, TEK 7.89226
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA3, ADRA2A, ADRA2C, ALOX15, ALOX5, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, EGFR, ESR1, F10, FLT3, FUT7, GPR35, HCAR2, HSD11B1, HSD11B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MAOB, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPRS, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2 6.83137
[CC] GO:0044425 membrane part ABCB1, ACHE, ADORA3, ADRA2A, ADRA2C, ALOX15, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, GPR35, HCAR2, HSD11B1, HSD11B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MAOB, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPRS, SRC, TBXAS1, TEK 6.10207
[CC] GO:0031224 None ABCB1, ACHE, ADORA3, ADRA2A, ADRA2C, ALPL, AXL, CA12, CA14, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, EGFR, ESR1, F10, FLT3, FUT7, GPR35, HCAR2, HSD11B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MAOB, MET, PTPRS, TBXAS1, TEK 3.35636
[CC] GO:0098590 plasma membrane region ABCB1, ADRA2A, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, EGFR, HTR2A, INSR, MET, PTGS2, SRC, TEK 3.20041
[CC] GO:0044464 cell part ABCB1, ACHE, ADORA3, ADRA2A, ADRA2C, AKR1B1, ALOX15, ALOX5, ALPL, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, FUT7, GPR35, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MAOB, MET, MMP12, MMP2, MMP9, NQO2, NR1H4, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPRS, RORC, SMAD3, SRC, TBXAS1, TEK, THRA, THRB, TNKS, TNKS2, TOP1, TUBB3, XDH 2.65207
[CC] GO:0016021 None ABCB1, ADORA3, ADRA2A, ADRA2C, ALPL, AXL, CA12, CA14, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, EGFR, ESR1, FLT3, FUT7, GPR35, HCAR2, HSD11B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MAOB, MET, PTPRS, TBXAS1, TEK 2.56187
[CC] GO:0045121 membrane raft CNR1, EGFR, HTR2A, INSR, KDR, PTGS2, SRC, TEK 2.49904
[CC] GO:0098857 membrane microdomain CNR1, EGFR, HTR2A, INSR, KDR, PTGS2, SRC, TEK 2.485
[CC] GO:0043005 None ADRA2C, CA2, CHRM1, CHRM2, CNR1, CNR2, HTR2A, HTR2B, HTR5A, PTGS2, PTPRS, SRC, TUBB3 2.46473
[CC] GO:0120025 None ADRA2C, AKR1B1, CA2, CHRM1, CHRM2, CNR1, CNR2, HTR2A, HTR2B, HTR5A, HTR6, PIK3CA, PTGS2, PTPRS, SRC, TEK, TUBB3 2.36583
[CC] GO:0042995 cell projection ADRA2C, AKR1B1, CA2, CHRM1, CHRM2, CNR1, CNR2, HTR2A, HTR2B, HTR5A, HTR6, PIK3CA, PTGS2, PTPRS, SRC, TEK, TUBB3 2.1282
[CC] GO:0016323 basolateral plasma membrane ADRA2A, CA2, CA4, CA9, EGFR, TEK 2.04883
[CC] GO:0098589 membrane region CNR1, EGFR, HTR2A, INSR, KDR, PTGS2, SRC, TEK 2.0373
[MF] GO:0008227 None ADRA2A, ADRA2C, CHRM1, CHRM2, CHRM4, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 19.9675
[MF] GO:0099528 None CHRM1, CHRM2, CHRM4, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 19.1933
[MF] GO:0004993 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.111
[MF] GO:0099589 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.111
[MF] GO:0043176 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 16.0886
[MF] GO:0051378 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 16.0886
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, EGFR, ESR1, F10, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, INSR, KDR, KIT, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR1H4, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPRS, RORC, SMAD3, SRC, TBXAS1, TEK, THRA, THRB, TNKS, TNKS2, TOP1, TUBB3, XDH 15.6391
[MF] GO:0038023 signaling receptor activity ADORA3, ADRA2A, ADRA2C, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, EGFR, ESR1, FLT3, GPR35, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, NR1H4, PPARA, RORC, TEK, THRA, THRB 14.7775
[MF] GO:0004872 receptor activity ADORA3, ADRA2A, ADRA2C, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, EGFR, ESR1, FLT3, GPR35, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, NR1H4, PPARA, RORC, TEK, THRA, THRB 13.1808
[MF] GO:0030594 None CHRM1, CHRM2, CHRM4, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 12.989
[MF] GO:0060089 molecular transducer activity ADORA3, ADRA2A, ADRA2C, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, EGFR, ESR1, FLT3, GPR35, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, NR1H4, PPARA, RORC, TEK, THRA, THRB 12.8276
[MF] GO:0004871 signal transducer activity ADORA3, ADRA2A, ADRA2C, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, EGFR, ESR1, FLT3, GPR35, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, NR1H4, PPARA, RORC, SMAD3, TEK, THRA, THRB 12.8099
[MF] GO:0099600 transmembrane receptor activity ADORA3, ADRA2A, ADRA2C, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, EGFR, FLT3, GPR35, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, TEK 10.8259
[MF] GO:0004888 transmembrane signaling receptor activity ADORA3, ADRA2A, ADRA2C, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, EGFR, FLT3, GPR35, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, TEK 10.8259
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, MMP1, MMP12, MMP2, MMP9, NQO2, NR1H4, PIM1, PPARA, RORC, SMAD3, TBXAS1, THRA, THRB, TNKS, XDH 10.8185
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 10.5853
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.87078
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CHRM1, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, HSPA1A, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, SRC, TEK, TOP1 9.7143
[MF] GO:0070405 ammonium ion binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 9.22561
[MF] GO:0003824 catalytic activity ABCB1, ACHE, AKR1B1, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DUSP3, EGFR, F10, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPRS, SRC, TBXAS1, TEK, TNKS, TNKS2, TOP1, TUBB3, XDH 8.689
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, TEK 8.39852
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F10, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, KIT, MMP1, MMP12, MMP2, MMP9, NQO2, NR1H4, NUAK1, PDE5A, PIM1, PPARA, PTGS1, PTGS2, RORC, SMAD3, TBXAS1, THRA, THRB, TNKS, TNKS2, XDH 7.96187
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, TEK 7.55816
[MF] GO:0004930 None ADORA3, ADRA2A, ADRA2C, CHRM1, CHRM2, CHRM4, CNR1, CNR2, GPR35, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 7.08455
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, MMP1, MMP12, MMP2, MMP9, NQO2, NR1H4, PPARA, RORC, SMAD3, THRA, THRB, TNKS 6.09936
[MF] GO:0016491 oxidoreductase activity AKR1B1, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, HSD11B1, HSD11B2, HSD17B1, MAOB, NQO2, PTGS1, PTGS2, TBXAS1, XDH 6.03078
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR, NQO2, THRA, THRB 6.00129
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.96075
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK 5.72108
[MF] GO:0097159 organic cyclic compound binding ABCB1, ADRA2A, ADRA2C, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, EGFR, ESR1, FLT3, HSD11B2, HSD17B1, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, INSR, KDR, KIT, MAOB, MET, MMP12, NQO2, NR1H4, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, RORC, SMAD3, SRC, TBXAS1, TEK, THRA, THRB, TOP1, TUBB3, XDH 5.34543
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, HSD11B2, HSD17B1, MAOB, NQO2, PTGS1, PTGS2, SRC, TBXAS1, XDH 5.1992
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIM1, SRC, TEK, TOP1 5.188
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR, KIT 5.12966
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.12201
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1 4.9197
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, NR1H4, PPARA, RORC, THRA, THRB 4.9144
[MF] GO:0004879 nuclear receptor activity ESR1, NR1H4, PPARA, RORC, THRA, THRB 4.9144
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, SRC, TBXAS1 4.79234
[MF] GO:0043560 insulin receptor substrate binding IGF1R, INSR, PIK3CA, PIK3CB 4.79234
[MF] GO:0036094 small molecule binding ABCB1, AURKB, AXL, CSNK2A1, DAO, EGFR, FABP3, FABP4, FLT3, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MAOB, MET, NQO2, NR1H4, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1, TUBB3, XDH 4.61823
[MF] GO:0043168 anion binding ABCB1, ALOX15, AURKB, AXL, CSNK2A1, DAO, EGFR, F10, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MAOB, MET, NQO2, NR1H4, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PTPRS, SRC, TEK, TOP1, TUBB3, XDH 4.61823
[MF] GO:1901363 heterocyclic compound binding ABCB1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, EGFR, ESR1, FLT3, HSD11B2, HSD17B1, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, INSR, KDR, KIT, MAOB, MET, MMP12, NQO2, NR1H4, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, RORC, SMAD3, SRC, TBXAS1, TEK, THRA, THRB, TOP1, TUBB3, XDH 4.61769
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, SRC, TBXAS1 4.56922
[MF] GO:0003707 steroid hormone receptor activity ESR1, NR1H4, PPARA, RORC, THRA, THRB 4.48559
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1 4.44766
[MF] GO:0000166 nucleotide binding ABCB1, AURKB, AXL, CSNK2A1, DAO, EGFR, FLT3, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MAOB, MET, NQO2, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1, TUBB3, XDH 4.3283
[MF] GO:1901265 nucleoside phosphate binding ABCB1, AURKB, AXL, CSNK2A1, DAO, EGFR, FLT3, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MAOB, MET, NQO2, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1, TUBB3, XDH 4.32814
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, XDH 4.15829
[MF] GO:0016907 None CHRM1, CHRM2, CHRM4 4.07112
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1 3.58741
[MF] GO:0004887 None NR1H4, THRA, THRB 3.58741
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.56518
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.37672
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F10, KIT, MMP1, MMP12, MMP2, MMP9, NQO2, NR1H4, NUAK1, PDE5A, PIM1, PPARA, PTGS1, PTGS2, RORC, SMAD3, TBXAS1, THRA, THRB, TNKS, TNKS2, XDH 3.37388
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TBXAS1 3.28388
[MF] GO:0044877 macromolecular complex binding ACHE, ADRA2A, CSNK2A1, EGFR, FLT3, HTR2A, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, SMAD3, SRC, THRA 3.15625
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, MAOB, NQO2, XDH 3.15552
[MF] GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity EGFR, KIT, MET, PIK3CA, PIK3CB 3.07296
[MF] GO:0032403 protein complex binding ACHE, ADRA2A, EGFR, FLT3, HTR2A, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, SMAD3, SRC, THRA 3.01651
[MF] GO:0052813 phosphatidylinositol bisphosphate kinase activity EGFR, KIT, MET, PIK3CA, PIK3CB 2.99557
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.90935
[MF] GO:0003845 None HSD11B1, HSD11B2 2.90935
[MF] GO:0071886 None HTR2A, HTR2C 2.90935
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 2.8775
[MF] GO:0035004 phosphatidylinositol 3-kinase activity EGFR, KIT, MET, PIK3CA, PIK3CB 2.8685
[MF] GO:0005524 ATP binding ABCB1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1 2.71394
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, CBR1, HSD11B1, HSD11B2, HSD17B1, XDH 2.67026
[MF] GO:0005496 steroid binding ESR1, HSD11B2, HSD17B1, NR1H4, RORC 2.59338
[MF] GO:0032559 adenyl ribonucleotide binding ABCB1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1 2.59338
[MF] GO:0030554 adenyl nucleotide binding ABCB1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1 2.56187
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.55147
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.49904
[MF] GO:0004949 None CNR1, CNR2 2.49904
[MF] GO:0004938 None ADRA2A, ADRA2C 2.49904
[MF] GO:0015464 None CHRM1, CHRM2, CHRM4 2.44085
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1 2.41906
[MF] GO:0032555 purine ribonucleotide binding ABCB1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1, TUBB3 2.39475
[MF] GO:0017076 purine nucleotide binding ABCB1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1, TUBB3 2.3604
[MF] GO:0032553 ribonucleotide binding ABCB1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1, TUBB3 2.35138
[MF] GO:0003674 molecular_function ABCB1, ACHE, ADORA3, ADRA2A, ADRA2C, AKR1B1, ALOX15, ALOX5, ALPL, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, FUT7, GPR35, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR1H4, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPRS, RORC, SMAD3, SRC, TBXAS1, TEK, THRA, THRB, TNKS, TNKS2, TOP1, TUBB3, XDH 2.23478
[MF] GO:0035639 purine ribonucleoside triphosphate binding ABCB1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1, TUBB3 2.12723
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.0746
[MF] GO:0043559 insulin binding IGF1R, INSR 2.07144
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, CBR1, HSD11B1, HSD11B2, HSD17B1 2.04243
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX15, ALOX5, PTGS2 2.03791
[MF] GO:0005057 signal transducer activity, downstream of receptor EGFR, INSR, KDR, KIT, SMAD3 2.00409
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1 2.00086
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX15, ALOX5, PTGS2 2.00086


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, THRB, CHRM1, THRA, HTR1E, GPR35, CHRM4, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, HTR2A, HTR5A, ADRA2C, HTR4, ADRA2A, HTR6, HTR7, CNR2, CNR1, ADORA3 18.7929
Serotonergic synapse_Homo sapiens_hsa04726 MAOB, HTR1E, ALOX15, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, HTR2A, PTGS2, HTR5A, HTR4, PTGS1, HTR6, HTR7, ALOX5 17.498
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 8.6763
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, HTR6, CHRM1, PIK3CA, HTR1E, HTR1D, HTR1A, HTR1B, PIK3CB, PPARA, HTR4 8.5702
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.5552
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, CNR1, INSR, KIT, KDR, TEK, PIK3CB, MET, EGFR, IGF1R 7.1708
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, HTR6, HTR7, CHRM1, HTR2B, HTR2C, HTR2A, HTR5A, HTR4, EGFR 6.815
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, MMP1, MMP2, PIK3CB, PTGS2, MMP9, EGFR, IGF1R, PIK3CA, KIT, BCL2, MET 6.4546
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, EGFR, IGF1R 6.4546
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, EGFR, HSPA1A 6.6015
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CHRM1, PIK3CA, INSR, KIT, KDR, BCL2, TEK, PIK3CB, MET, EGFR, IGF1R 6.3146
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.815
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, PIK3CA, INSR, KIT, KDR, TEK, PIK3CB, MET, EGFR, IGF1R 6.1011
Adherens junction_Homo sapiens_hsa04520 SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 6.3146
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM1, PIK3CA, CHRM4, BCL2, PIK3CB 5.2612
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, INSR, PIK3CB, PTGS2, PTGS1 5.7113
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, INSR, BCL2, TEK, PIK3CB, EGFR, IGF1R 5.4345
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, TBXAS1, PTGS2, PTGS1 5.4715
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, KIT, PIK3CB, MET, EGFR 5.3199
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, BCL2, PIK3CB, MET, EGFR, IGF1R 4.6276
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, HTR2B, HTR2C, PIK3CB, HTR2A 4.4695
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, PIK3CA, MMP2, BCL2, PIM1, PIK3CB 4.4283
MicroRNAs in cancer_Homo sapiens_hsa05206 ABCB1, PIK3CA, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, EGFR 4.3718
Gap junction_Homo sapiens_hsa04540 SRC, TUBB3, HTR2B, HTR2C, HTR2A, EGFR 4.7047
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, PTGS2 4.8649
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, INSR, PDE5A, PIK3CB, ADRA2C, ADRA2A 4.2766
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.0739
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, KIT, PIM1, PIK3CB 4.4479
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KIT, KDR, MET, EGFR, IGF1R, HSPA1A 4.0095
Metabolic pathways_Homo sapiens_hsa01100 CBR1, MAOB, ALOX15, AKR1B1, PTGS2, CYP19A1, PTGS1, HSD11B1, FUT7, DAO, ALOX5, HSD17B1, TBXAS1, CYP1A2, CYP1A1, ALPL, XDH 3.8976
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 THRB, PIK3CA, THRA, SRC, PIK3CB, ESR1 4.116
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 4.3507
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, INSR, PIK3CB, IGF1R, HSPA1A 4.2766
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB, MET, EGFR, IGF1R 4.0837
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM1, PIK3CA, SRC, CHRM4, PIK3CB, EGFR 3.7149
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, PIK3CA, INSR, PIK3CB, EGFR, IGF1R 3.8976
Hepatitis B_Homo sapiens_hsa05161 SMAD3, PIK3CA, SRC, BCL2, PIK3CB, MMP9 3.7149
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1 4.038
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB, EGFR, IGF1R 3.7149
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB, HSPA1A 3.1548
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, TBXAS1, PIK3CB, PTGS1 3.1259
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, INSR, KIT, PIK3CB, EGFR 2.8289
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2, EGFR 2.6788
Glioma_Homo sapiens_hsa05214 PIK3CA, PIK3CB, EGFR, IGF1R 3.1338
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, PIK3CA, BCL2, PIK3CB 3.1836
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, PIK3CA, PIK3CB, EGFR 3.1259
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1 2.9996
Taste transduction_Homo sapiens_hsa04742 HTR1E, HTR1D, HTR1A, HTR1B 2.7894
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB, HSPA1A 2.2712
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PIK3CB, EGFR 2.7284
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, INSR, PIK3CB, IGF1R 2.6178
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.3867
Insulin resistance_Homo sapiens_hsa04931 PIK3CA, INSR, PIK3CB, PPARA 2.3938
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 2.8752
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, BCL2, PIK3CB, PTGS2 2.7392
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.2892
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, BCL2, PIK3CB 2.2765
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.0616
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA, EGFR 2.1349
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, PIK3CA, INSR, PIK3CB 3.9017
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB, HSPA1A 2.1131
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, INSR, PIK3CB, IGF1R 2.2383
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, PIK3CA, PIK3CB, IGF1R 2.0586
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, INSR, PIK3CB, PPARA 1.9859
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET, EGFR 1.8456
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, PIK3CB 1.9245
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.756
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.3431
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2491
Alcoholism_Homo sapiens_hsa05034 MAOB 0.2558
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PIK3CB 1.286
Insulin signaling pathway_Homo sapiens_hsa04910 PIK3CA, INSR, PIK3CB 1.3462
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, IGF1R 1.7133
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, BCL2, PIK3CB 1.4981
Tryptophan metabolism_Homo sapiens_hsa00380 MAOB, CYP1A2, CYP1A1, CYP1B1 3.8935
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.2973
Phagosome_Homo sapiens_hsa04145 TUBB3 0.2973
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.7849
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB, EGFR 1.683
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.3351
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB, HSPA1A 1.14
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, SRC, PIK3CB 0.9991
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3, PIK3CA, PIK3CB 1.654
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 1.0738
Axon guidance_Homo sapiens_hsa04360 MET 0.3469
Cell cycle_Homo sapiens_hsa04110 SMAD3 0.3518
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3518
Dopaminergic synapse_Homo sapiens_hsa04728 MAOB 0.3446
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, HSPA1A 0.8164
HTLV-I infection_Homo sapiens_hsa05166 SMAD3, PIK3CA, PIK3CB 0.8091
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3, PIK3CA, PIK3CB 2.016
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 1.7645
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.6564
Purine metabolism_Homo sapiens_hsa00230 PDE5A, XDH 0.637
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.6353
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4151
Melanogenesis_Homo sapiens_hsa04916 KIT 0.4158
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 0.7765
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.7667
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.7889
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.7587
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.1131
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4279
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4271
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 0.9223
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 0.9322
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 0.9539
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4492
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 0.961
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 0.9965
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.4628
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1, PTGS2 0.9504
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4479
Non-small cell lung cancer_Homo sapiens_hsa05223 PIK3CA, PIK3CB, EGFR 2.2784
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.0843
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.013
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 1.0216
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2, NR1H4 2.0438
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB, EGFR 2.357
Complement and coagulation cascades_Homo sapiens_hsa04610 F10 0.482
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.4884
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.502
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5
Peroxisome_Homo sapiens_hsa04146 DAO, XDH 1.0623
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.149
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5144
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.1912
Amphetamine addiction_Homo sapiens_hsa05031 MAOB 0.5277
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.1663
Shigellosis_Homo sapiens_hsa05131 SRC 0.536
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, INSR, PIK3CB 2.4356
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 MAOB, CYP1A2 1.1843
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5632
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.2769
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.2224
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.2224
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B1 0.5664
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.5901
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3 0.5901
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.613
Malaria_Homo sapiens_hsa05144 MET 0.6253
Cocaine addiction_Homo sapiens_hsa05030 MAOB 0.6253
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6351
Arginine and proline metabolism_Homo sapiens_hsa00330 DAO, MAOB 1.4048
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.637
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.6478
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.486
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7286
Galactose metabolism_Homo sapiens_hsa00052 AKR1B1 0.7698
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.7983
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7637
Tyrosine metabolism_Homo sapiens_hsa00350 MAOB 0.7286
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B1 0.7208
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B1 0.758
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 DAO, MAOB 1.5732
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8063
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7698
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.8052
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7983
Histidine metabolism_Homo sapiens_hsa00340 MAOB 0.8277
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9859
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOB 0.9539
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.013
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.1406


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)