TCM Prescription: Yang Xue Qing Nao Pills



Prescription Description
Prescription IDTCMF838
Pinyin NameYang Xue Qing Nao Wan 
Chinese Name养血清脑丸
English NameYang Xue Qing Nao Pills
Function Description头痛, 眩晕眼花, 心烦易怒, 失眠多梦
IndicationsVertigo disorder, Insomnia
Disease ICD-11 Category SD22 [Vertigo disorder (TM1), 眩晕 (TM1) ];
7A0Z [Insomnia disorders, unspecified, 失眠障碍，未特指的 ];
Human Tissues Associated with IndicationBrain, Heart, Blood
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH1966 Rehmannia glutinosa 熟地黄 TCMH1966 ITSAH4578-14
TCMH695 Uncaria rhynchophylla 钩藤 TCMH695 ITSAM939-14
TCMH1036 Spatholobus suberectus 鸡血藤 TCMH1036 ITSAK2607-14
TCMH2244 Prunella vulgaris 夏枯草 TCMH2244 ITSAH2424-14
TCMH1199 Cassia tora 决明子 TCMH1199 GENG109-13
TCMH2610 Concha margaritifera usta;Margarita 珍珠母 TCMH2610
TCMH2376 Corydalis yanhusuo 延胡索 TCMH2376
TCMH2239 Asarum sieboldii 细辛 TCMH2239 ITSAI1576-14
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT158 EPHX2 Epoxide hydratase Lyase P34913
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT220 CYP2J2 Cytochrome P450 2J2 Oxidoreductase P51589
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT407 MYLK Myosin light chain kinase, smooth muscle Kinase Q15746
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT615 SENP8 Sentrin-specific protease 8 Protease Q96LD8
TCMT616 SENP7 Sentrin-specific protease 7 Protease Q9BQF6
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT643 ADRA1A Alpha-1a adrenergic receptor GPCR P35348
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT675 ADRB1 Beta-1 adrenergic receptor GPCR P08588
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT704 ERBB2 Receptor protein-tyrosine kinase erbB-2 Kinase P04626
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT778 KCNA5 Voltage-gated potassium channel subunit Kv1.5 Ion channel P22460
TCMT780 CACNA1D Voltage-gated L-type calcium channel alpha-1D subunit Ion channel Q01668
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT853 SIGMAR1 Sigma opioid receptor Unclassified Q99720
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT899 ALDH2 Aldehyde dehydrogenase Oxidoreductase P05091


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 13.867
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 12.9867
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA1A, ADRB1, AKR1B1, AXL, CA2, CA7, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, F10, F3, FLT3, HCAR2, HTR2A, HTR2B, HTR6, KDR, MET, MMP12, MMP9, PTPN1, SRC, XDH 10.0647
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA1A, ADRB1, AKR1B1, AXL, CA2, CA7, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, F10, F3, FLT3, HCAR2, HTR2A, HTR2B, HTR6, KDR, MET, MMP12, MMP9, PTPN1, SRC, XDH 10.0647
[BP] GO:0003018 None ADORA1, ADRA1A, ADRB1, DRD1, EGFR, EPHX2, HTR1A, HTR2A, HTR2B, HTR7, SRC 8.38159
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, FABP3, PPARA 8.29658
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALDH2, ALOX5, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1B1, CYP2A13, CYP2A6, CYP2D6, EPHX2, FABP3, FUT7, HTR2B, PIM1, PPARA, XDH 8.19638
[BP] GO:0097746 None ADORA1, ADRA1A, ADRB1, DRD1, EGFR, EPHX2, HTR1A, HTR2A, HTR2B, HTR7 8.08735
[BP] GO:0035296 None ADORA1, ADRA1A, ADRB1, DRD1, EGFR, EPHX2, HTR1A, HTR2A, HTR2B, HTR7 8.08735
[BP] GO:0050880 None ADORA1, ADRA1A, ADRB1, DRD1, EGFR, EPHX2, HTR1A, HTR2A, HTR2B, HTR7 7.85399
[BP] GO:0035150 None ADORA1, ADRA1A, ADRB1, DRD1, EGFR, EPHX2, HTR1A, HTR2A, HTR2B, HTR7 7.83961
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA1A, ADRB1, AKR1B1, AXL, CYP1B1, DRD2, EGFR, ERBB2, F10, F3, FLT3, HTR2A, HTR2B, HTR6, KDR, MET, PTPN1, SRC, XDH 7.83447
[BP] GO:0003013 None ADORA1, ADRA1A, ADRB1, DRD1, EGFR, EPHX2, HTR1A, HTR2A, HTR2B, HTR7, SRC 7.36178
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, HTR2A, HTR2B, KDR, SRC 7.30912
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA1A, AKR1B1, CDC25B, CYP1B1, DRD2, DRD3, EGFR, ERBB2, F3, FABP3, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, SRC, XDH 7.15946
[BP] GO:0007210 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.12255
[BP] GO:0098664 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.12255
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA1A, ADRB1, AKR1B1, AXL, CYP1B1, DRD2, DRD3, EGFR, ERBB2, F10, F3, FLT3, HTR2A, HTR2B, HTR6, KDR, MET, MMP12, MMP9, PTPN1, SRC, XDH 7.08031
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, FABP3, PPARA 7.03406
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA1A, ADRB1, AKR1B1, AURKB, AXL, CA12, CA2, CA7, CACNA1C, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, EPHX2, F10, F3, FABP3, FABP4, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR7, KDR, MET, PPARA, SRC, XDH 6.86232
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, EGFR, HCAR2, HTR2A, HTR2B, KDR, SRC 6.80271
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA1A, ADRB1, AKR1B1, AURKB, AXL, CA2, CA7, CACNA1C, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, F10, F3, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MMP12, MMP9, PTPN1, SRC, XDH 6.78892
[BP] GO:0007187 None ADORA1, ADRA1A, ADRB1, DRD1, DRD2, DRD3, HTR1A, HTR5A, HTR6, HTR7 6.72945
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA1A, ADRB1, AKR1B1, AURKB, AXL, CA2, CA7, CACNA1C, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, F10, F3, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MMP12, MMP9, PTPN1, SRC, XDH 6.66732
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA1A, ADRB1, AKR1B1, AKR1B10, ALOX5, ALPL, AXL, CACNA1C, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, EPHX2, F10, F3, FABP4, HTR1A, HTR2A, HTR2B, HTR7, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RORC, SRC 6.56626
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA1A, ADRB1, AKR1B1, AURKB, AXL, CYP1B1, DRD2, DRD3, EGFR, ERBB2, F10, F3, FLT3, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MMP9, PTPN1, SRC, XDH 6.40966
[BP] GO:0042592 homeostatic process ADORA1, ADRA1A, ADRB1, AKR1B1, AXL, CA12, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, EGFR, EPHX2, FABP3, FABP4, FLT3, HTR2A, HTR2B, MET, SRC 6.40652
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, DRD3, EGFR, ERBB2, F10, F3, MET, SRC, XDH 6.19957
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA1A, ADRB1, AKR1B1, AURKB, AXL, CA2, CA7, CDC25B, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, F10, F3, FABP3, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, XDH 6.1421
[BP] GO:0007188 None ADORA1, ADRA1A, ADRB1, DRD1, DRD2, DRD3, HTR1A, HTR5A, HTR7 6.11785
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CDC25B, DRD2, DRD3, EGFR, ERBB2, F3, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1 6.07387
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, AXL, CA2, CA7, CACNA1C, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, F10, F3, HCAR2, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, SRC 6.00536
[BP] GO:0006811 None ADRA1A, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, DRD1, DRD2, DRD3, FABP3, HTR2A, HTR2B, PPARA 5.9813
[BP] GO:0097756 None ADORA1, ADRA1A, HTR1A, HTR2A, HTR2B, HTR7 5.9813
[BP] GO:0042221 response to chemical ADRA1A, AKR1B1, ALPL, AXL, CA2, CA3, CA9, CYP1B1, DRD1, DRD2, DRD3, EGFR, EPHX2, ERBB2, FABP3, FABP4, FLT3, HTR2A, HTR2B, HTR5A, IGF1R, KDR, MMP2, MMP9, PPARA, RORC, SRC 5.90046
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA1A, ADRB1, AKR1B1, AURKB, AXL, CA2, CA7, CDC25B, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, EPHX2, ERBB2, F10, F3, FABP3, FABP4, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, XDH 5.84844
[BP] GO:0019932 second-messenger-mediated signaling ADRA1A, ADRB1, CACNA1C, DRD1, DRD2, DRD3, EGFR, HTR2B, HTR5A, KDR 5.83151
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD2, EGFR, EPHX2, ERBB2, FABP3, FABP4, FUT7, MET, PPARA 5.74957
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA1A, ADRB1, AKR1B1, AXL, CYP1B1, DRD2, DRD3, EGFR, ERBB2, F10, F3, FABP4, FLT3, HTR2A, HTR2B, HTR6, KDR, MET, MMP12, MMP2, MMP9, PTPN1, SRC, XDH 5.70056
[BP] GO:0042493 response to drug ADRA1A, AKR1B1, AXL, CA3, CA9, CYP1B1, DRD1, DRD2, DRD3, EGFR, FABP3, HTR2A, HTR2B, KDR, SRC 5.48031
[BP] GO:0006939 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7 5.47753
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1B1, CYP2A13, CYP2A6, CYP2D6 5.32681
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, F10, F3, IGF1R, KDR, MET, MMP9, SRC 5.26656
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, CACNA1C, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, ERBB2, F10, F3, IGF1R, KDR, MET, MMP9, SRC 5.25368
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, DRD3, EPHX2, FABP3, FLT3, HCAR2, HTR2A, HTR2B, PPARA, RORC, SRC 5.18465
[BP] GO:0010033 response to organic substance ADRA1A, AKR1B1, ALPL, AXL, CA2, CA3, CA9, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, FABP3, FABP4, FLT3, HTR5A, IGF1R, KDR, MMP2, PPARA, RORC, SRC 5.06697
[BP] GO:0042310 None ADRA1A, HTR1A, HTR2A, HTR2B, HTR7 5.00889
[BP] GO:0008152 metabolic process ACHE, ADORA1, ADRB1, AKR1B1, AKR1B10, ALDH2, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CYP19A1, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, EGFR, EPHX2, ERBB2, F10, F3, FABP3, FABP4, FLT3, FUT7, HTR1A, HTR2B, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, XDH 4.9886
[BP] GO:0048878 chemical homeostasis ADRA1A, AKR1B1, CA12, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, EGFR, EPHX2, FABP3, FABP4, HTR2A, HTR2B, MET 4.95241
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, EGFR, HTR2A 4.9244
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, EGFR, HTR2A 4.9244
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, ERBB2, F10, F3, IGF1R, KDR, MET, MMP9, SRC 4.92373
[BP] GO:0001659 None ADORA1, ADRB1, DRD1, DRD2, HTR2A 4.88768
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD2, EGFR, EPHX2, ERBB2, FABP3, FABP4, FUT7, MET, PPARA 4.85955
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA1A, ADRB1, CDC25B, DRD1, DRD2, EGFR, ERBB2, FABP3, FLT3, HTR2A, HTR2B, KDR, MMP9, PTPN1, SRC, XDH 4.85955
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA1A, ADRB1, CDC25B, DRD1, DRD2, EGFR, ERBB2, FABP3, FLT3, HTR2A, HTR2B, KDR, MMP9, PTPN1, SRC, XDH 4.85955
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, ADRA1A, CA2, CA7, DRD2 4.83519
[BP] GO:0050795 None ADORA1, DRD2, DRD3, HTR1A, HTR2A, HTR2B 4.83084
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, CA3, CYP1B1, DRD1, DRD2, DRD3, EPHX2, KDR, SRC 4.81119
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA1A, ADRB1, CDC25B, DRD1, DRD2, DRD3, EGFR, ERBB2, FABP3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 4.79635
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA1A, ADRB1, CDC25B, DRD1, DRD2, DRD3, EGFR, ERBB2, FABP3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 4.74127
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA1A, DRD2, EGFR, ERBB2, FLT3, HTR2A, HTR2B, KDR, PTPN1, SRC, XDH 4.72738
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, CA3, CA9, CYP1B1, DRD1, DRD2, DRD3, EGFR, FABP3, HTR5A, IGF1R, MMP2, MMP9, PPARA, RORC, SRC 4.71721
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA1A, ADRB1, AKR1B1, ALPL, AURKB, AXL, CA2, CA3, CA6, CA9, CYP1B1, DRD1, DRD2, DRD3, EGFR, EPHX2, ERBB2, F10, F3, FABP3, FABP4, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, IGF1R, KDR, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, SRC 4.68134
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, EGFR, HTR6 4.67466
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, ADRB1, AKR1B1, DRD1, DRD2, HTR2A, MET 4.61378
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, ALDH2, CYP1B1, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, EGFR, EPHX2 4.60019
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, ADRA1A, CA2, CA7, DRD1, DRD2, EGFR 4.55445
[BP] GO:0007198 None HTR1A, HTR5A, HTR7 4.55445
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CYP1B1, EGFR, F3, FLT3, HCAR2, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SIGMAR1, SRC, XDH 4.55428
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, KDR, MET, MMP9, SRC 4.51444
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, SRC 4.49242
[BP] GO:0007193 None ADORA1, DRD2, DRD3, HTR1A, HTR5A, HTR7 4.4544
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, SRC 4.44719
[BP] GO:0050801 ion homeostasis ADRA1A, CA12, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, EGFR, EPHX2, FABP3, HTR2A, HTR2B 4.40177
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CYP1B1, EGFR, F3, FLT3, HCAR2, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SIGMAR1, SRC, XDH 4.3842
[BP] GO:0051049 regulation of transport ACHE, ADORA1, AXL, CA2, CA7, CACNA1C, CYP19A1, DRD1, DRD2, DRD3, EGFR, ERBB2, HCAR2, HTR1A, HTR2A, HTR2B, MMP12, MMP9, PPARA, PTPN1, SRC 4.3842
[BP] GO:0035556 intracellular signal transduction ADRA1A, ADRB1, AKR1B1, AXL, CACNA1C, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, HTR2A, HTR2B, HTR5A, IGF1R, KDR, MET, PTPN1, SRC 4.35882
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA1A, ADRB1, AKR1B1, AXL, CA1, CA2, CACNA1C, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SIGMAR1, SRC 4.35151
[BP] GO:0046777 protein autophosphorylation AURKB, EGFR, ERBB2, FLT3, IGF1R, KDR, PIM1, SRC 4.34968
[BP] GO:0045776 None ADORA1, ADRB1, DRD2, DRD3, PPARA 4.33697
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ADRA1A, DRD2, EGFR, ERBB2, HTR2A, HTR2B, KDR, PTPN1, SRC 4.33697
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CACNA1C, CYP19A1, DRD2, DRD3, EGFR, HCAR2, HTR1A, HTR2A, HTR2B, MMP12, SRC 4.33697
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, SRC 4.29511
[BP] GO:0090066 None ADORA1, ADRA1A, ADRB1, DRD1, EGFR, EPHX2, HTR1A, HTR2A, HTR2B, HTR7 4.26374
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, EGFR, HCAR2, HTR2B, MMP12, SRC 4.12941
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA1A, DRD2, EGFR, ERBB2, FLT3, HTR2A, HTR2B, IGF1R, KDR, PTPN1, SRC, XDH 4.0976
[BP] GO:0009719 response to endogenous stimulus ADRA1A, AKR1B1, ALPL, CA2, CA9, DRD1, EGFR, ERBB2, FABP3, FLT3, HTR5A, IGF1R, MMP2, PPARA, SRC 4.08947
[BP] GO:0048148 None DRD1, DRD2, DRD3, HTR2A 4.07549
[BP] GO:0019933 None ADRA1A, ADRB1, DRD1, DRD2, DRD3, HTR5A 4.05427
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, ADRA1A, ADRB1, CA2, DRD1, DRD2, DRD3, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1, SRC 4.05054
[BP] GO:0008217 None ADORA1, ADRA1A, ADRB1, DRD2, DRD3, EPHX2, PPARA 4.03042
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 4.02048
[BP] GO:0051046 None ACHE, ADORA1, CACNA1C, CYP19A1, DRD2, DRD3, EGFR, HCAR2, HTR1A, HTR2A, HTR2B, MMP12, SRC 4.01726
[BP] GO:0019373 epoxygenase P450 pathway CYP1B1, CYP2A13, CYP2A6, EPHX2 4.0053
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, ERBB2, F10, F3, MET, SRC 3.98535
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CACNA1C, CYP19A1, CYP1B1, DRD2, EGFR, HCAR2, HTR1A, HTR2A 3.94899
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, DRD3, EGFR, HCAR2 3.94649
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1B1, CYP2A13, CYP2A6, CYP2D6, EPHX2 3.92007
[BP] GO:0019369 arachidonic acid metabolic process CYP1B1, CYP2A13, CYP2A6, CYP2D6, EPHX2 3.85468
[BP] GO:0019935 None ADRA1A, ADRB1, DRD1, DRD2, DRD3, HTR5A 3.85468
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA1A, CDC25B, DRD1, DRD2, EGFR, ERBB2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 3.84591
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CYP1B1, EGFR, F3, FLT3, HCAR2, HTR2B, IGF1R, KDR, MMP9, PIM1, PTPN1, SIGMAR1, SRC, XDH 3.84483
[BP] GO:0098771 inorganic ion homeostasis ADRA1A, CA12, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, EGFR, EPHX2, HTR2A, HTR2B 3.83685
[BP] GO:0007202 None ADRA1A, EGFR, HTR2A, HTR2B 3.79752
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1B1, CYP2A13, CYP2A6, CYP2D6, EPHX2 3.76973
[BP] GO:0009698 phenylpropanoid metabolic process CYP2A13, CYP2A6, CYP2D6 3.767
[BP] GO:0009804 coumarin metabolic process CYP2A13, CYP2A6, CYP2D6 3.767
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA1A, ADRB1, AXL, CA2, CYP1B1, DRD2, DRD3, EGFR, F3, HCAR2, HTR2A, HTR2B, KDR, MET, MMP12, MMP9, PIM1, SRC 3.74608
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA1A, CDC25B, DRD1, DRD2, EGFR, ERBB2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, MMP9, PTPN1, SRC, XDH 3.70897
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, DRD2, EGFR, HTR2A 3.69773
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 3.69414
[BP] GO:0051234 None ACHE, ADORA1, ADRA1A, ALOX5, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, DRD1, DRD2, DRD3, EGFR, F10, FABP3, HTR2A, HTR2B, MMP12, MMP9, PPARA, SIGMAR1, SRC, XDH 3.67099
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, EGFR, ERBB2, FLT3, HTR2A, HTR2B, IGF1R, PTPN1, SRC 3.67099
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALDH2, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CYP19A1, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, EGFR, EPHX2, ERBB2, F10, FABP3, FABP4, FLT3, FUT7, HTR1A, HTR2B, IGF1R, KDR, MET, MMP1, MMP2, PIM1, PPARA, PTPN1, RORC, SRC, XDH 3.67099
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA1A, CDC25B, DRD2, EGFR, ERBB2, FLT3, HTR2A, HTR2B, KDR, MMP9, PTPN1, SRC, XDH 3.6193
[BP] GO:0002793 None ACHE, ADORA1, DRD2, EGFR, HCAR2, HTR2B, MMP12, SRC 3.6193
[BP] GO:0090087 None ACHE, ADORA1, CA2, CACNA1C, DRD2, DRD3, EGFR, ERBB2, HCAR2, HTR2B, MMP12, PTPN1, SRC 3.60371
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, EGFR, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC 3.60094
[BP] GO:0051940 None DRD1, DRD2, DRD3 3.60094
[BP] GO:0051584 None DRD1, DRD2, DRD3 3.60094
[BP] GO:0002791 None ACHE, ADORA1, CACNA1C, DRD2, DRD3, EGFR, HCAR2, HTR2B, MMP12, SRC 3.59228
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2, HTR2A 3.5568
[BP] GO:0060402 None ADRA1A, CACNA1C, DRD2, HTR2A, HTR2B 3.5568
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, DRD1, DRD2, DRD3, HTR1A 3.55564
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, AXL, CA2, CYP19A1, DRD1, DRD2, DRD3, EGFR, ERBB2, HCAR2, HTR2B, MMP12, SRC 3.55464
[BP] GO:0046883 regulation of hormone secretion ADORA1, CACNA1C, CYP19A1, DRD2, EGFR, HCAR2, HTR1A, HTR2A 3.54648
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, ERBB2, FLT3, HTR2A, HTR2B, PTPN1, SRC 3.53685
[BP] GO:0010035 response to inorganic substance AKR1B1, AXL, CA2, CYP1B1, DRD2, EGFR, FABP4, KDR, MMP9, SRC 3.52586
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, AURKB, AXL, CA3, CDC25B, DRD1, DRD2, EGFR, EPHX2, ERBB2, FLT3, HTR2B, IGF1R, KDR, MET, PIM1, PTPN1, SRC, XDH 3.52509
[BP] GO:0016477 cell migration AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR2B, HTR6, KDR, MMP1, MMP12, MMP9, SRC 3.50473
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA1A, DRD1, DRD2, DRD3, EGFR, ERBB2, HTR2A, IGF1R, MET, MMP12, MMP9, PTPN1, SRC, XDH 3.48757
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA1A, DRD1, DRD2, DRD3, EGFR, ERBB2, HTR2A, IGF1R, MET, MMP12, MMP9, PTPN1, SRC, XDH 3.47262
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRA1A, ADRB1, AKR1B1, ALPL, AURKB, AXL, CA2, CA9, CACNA1C, CDC25B, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, ERBB2, FABP4, FLT3, FUT7, HTR2A, HTR2B, HTR5A, KDR, MET, MMP2, MMP9, PIM1, PPARA, RORC, SIGMAR1, SRC 3.46997
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRA1A, ADRB1, AKR1B1, AURKB, AXL, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, F10, F3, FABP4, FLT3, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MMP12, MMP2, MMP9, PPARA, PTPN1, SRC, XDH 3.46997
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRA1A, ADRB1, AKR1B1, AKR1B10, ALDH2, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CDC25B, CYP19A1, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, EGFR, EPHX2, ERBB2, F10, F3, FABP3, FABP4, FLT3, FUT7, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SIGMAR1, SRC, XDH 3.46997
[BP] GO:0071073 None FABP3, HTR2A, HTR2B 3.46997
[BP] GO:0006810 None ACHE, ADORA1, ADRA1A, ALOX5, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, DRD1, DRD2, DRD3, F10, FABP3, HTR2A, HTR2B, MMP12, MMP9, PPARA, SIGMAR1, SRC, XDH 3.45879
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA1A, CDC25B, DRD2, EGFR, ERBB2, FLT3, HTR2A, HTR2B, KDR, MMP9, PTPN1, SRC, XDH 3.45539
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, PPARA, SRC 3.4409
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling ERBB2, HTR2A, HTR2B, IGF1R 3.43648
[BP] GO:0009628 response to abiotic stimulus ADORA1, ADRB1, AKR1B1, AURKB, CA2, DRD1, DRD2, DRD3, EGFR, HTR2A, HTR2B, MMP2, PPARA, SRC 3.39598
[BP] GO:0014070 response to organic cyclic compound ALPL, CA2, CA9, CYP1B1, DRD1, DRD2, DRD3, EGFR, FLT3, HTR5A, RORC, SRC 3.39598
[BP] GO:0022029 None DRD1, DRD2, EGFR, HTR6 3.38909
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ADRA1A, DRD2, EGFR, HTR2A, HTR2B, KDR, SRC 3.38252
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, ALDH2, AURKB, CYP19A1, CYP1B1, CYP2A6, CYP2D6, EPHX2, FABP3, FABP4, FUT7, MMP1, MMP12, MMP2, MMP9, SRC, XDH 3.37745
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, SRC 3.36648
[BP] GO:0007189 None ADRA1A, ADRB1, DRD1, DRD2, DRD3 3.36648
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, EGFR, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC 3.3658
[BP] GO:0048511 rhythmic process AXL, DRD2, DRD3, EGFR, HTR7, PPARA, RORC, SRC 3.36285
[BP] GO:1903522 None ADORA1, ADORA3, ADRA1A, ADRB1, CACNA1C, DRD2, EGFR, HTR2A 3.35478
[BP] GO:0010863 positive regulation of phospholipase C activity ADRA1A, EGFR, HTR2A, HTR2B 3.35478
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA1A, ADRB1, AURKB, CDC25B, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FABP3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SRC, XDH 3.32668
[BP] GO:0040011 locomotion AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR2B, HTR6, KDR, MET, MMP1, MMP12, MMP9, SRC 3.3202
[BP] GO:0051179 None ACHE, ADORA1, ADRA1A, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, DRD1, DRD2, DRD3, EGFR, F10, FABP3, HTR2A, HTR2B, MMP12, MMP9, PPARA, SIGMAR1, SRC, XDH 3.30957
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, AURKB, AXL, CA3, CDC25B, DRD1, DRD2, EGFR, EPHX2, ERBB2, FLT3, HTR2B, IGF1R, KDR, MET, PIM1, PTPN1, SRC, XDH 3.28974
[BP] GO:0051952 None ADORA1, DRD1, DRD2, DRD3, HTR2A 3.27698
[BP] GO:0060401 None ADRA1A, CACNA1C, DRD2, HTR2A, HTR2B 3.27698
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA1A, ADRB1, AURKB, CDC25B, DRD1, DRD2, DRD3, EGFR, EPHX2, ERBB2, F3, FABP3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SRC, XDH 3.26787
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1B1, CYP2A13, CYP2A6, CYP2D6, EPHX2, FABP3, PPARA 3.25487
[BP] GO:0055080 cation homeostasis ADRA1A, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, EGFR, EPHX2, HTR2A, HTR2B 3.24649
[BP] GO:0007623 circadian rhythm DRD2, DRD3, EGFR, HTR7, PPARA, RORC 3.24504
[BP] GO:0002031 None DRD2, DRD3, HTR2B 3.24504
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA1A, ADRB1, AKR1B1, AURKB, AXL, CYP1B1, DRD2, DRD3, EGFR, ERBB2, F10, F3, FLT3, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MMP12, MMP9, PTPN1, SRC, XDH 3.24374
[BP] GO:0018958 None AKR1B1, DRD1, DRD2, DRD3, HTR1A 3.23617
[BP] GO:1900274 regulation of phospholipase C activity ADRA1A, EGFR, HTR2A, HTR2B 3.23225
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, DRD2, EGFR, ERBB2, FLT3, HTR2A, HTR2B, PTPN1, SRC 3.21491
[BP] GO:0032467 None AURKB, CDC25B, DRD2, DRD3 3.18984
[BP] GO:0044057 None ADORA1, ADORA3, ADRA1A, ADRB1, CACNA1C, DRD2, DRD3, EGFR, HCAR2, HTR2A 3.1821
[BP] GO:0048870 cell motility AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR2B, HTR6, KDR, MMP1, MMP12, MMP9, SRC 3.15814
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA1A, ADRB1, AURKB, CDC25B, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, MMP9, PTPN1, SRC, XDH 3.15814
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRA1A, ADRB1, AURKB, CDC25B, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC, XDH 3.13193
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, DRD3, EGFR, F3, FABP4, KDR, MET, MMP12, PPARA 3.12998
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALDH2, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, HTR1A 3.1289
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA1A, ADRB1, AURKB, CDC25B, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SRC, XDH 3.11487
[BP] GO:0051781 None AURKB, CDC25B, DRD2, DRD3, HTR2B 3.10643
[BP] GO:0045859 regulation of protein kinase activity ADORA1, CDC25B, DRD2, EGFR, ERBB2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, PTPN1, SRC 3.10643
[BP] GO:0072507 divalent inorganic cation homeostasis ADRA1A, CACNA1C, DRD1, DRD2, DRD3, EGFR, EPHX2, HTR2A, HTR2B 3.10521
[BP] GO:0009725 response to hormone ADRA1A, AKR1B1, ALPL, CA2, CA9, EGFR, FABP3, FLT3, HTR5A, PPARA, SRC 3.09149
[BP] GO:0006468 protein phosphorylation AURKB, AXL, CDC25B, DRD1, EGFR, ERBB2, FLT3, HTR2B, IGF1R, KDR, MET, PIM1, SRC 3.0872
[BP] GO:0050708 None ACHE, CACNA1C, DRD2, DRD3, EGFR, HCAR2, HTR2B, MMP12, SRC 3.06331
[BP] GO:0060134 None DRD1, DRD2, DRD3 3.05815
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic ADRA1A, CA2, CA7 3.05815
[BP] GO:0007200 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B 3.05048
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, DRD2, EGFR, ERBB2, FLT3, HTR2A, HTR2B, PTPN1, SRC 3.01683
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 3.01683
[BP] GO:0001997 None ADRA1A, ADRB1 3.01319
[BP] GO:2001023 None DRD1, DRD2, DRD3, HTR2A, MET 3.01143
[BP] GO:0050714 None ACHE, DRD2, EGFR, HCAR2, HTR2B, MMP12, SRC 2.9882
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1B1, CYP2A13, CYP2A6, CYP2D6, EPHX2 2.98599
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, DRD3 2.98062
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, DRD3 2.98062
[BP] GO:0051580 None DRD1, DRD2, DRD3 2.97652
[BP] GO:0051967 None ADORA1, DRD2, HTR2A 2.97652
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, DRD2, EGFR, ERBB2, FLT3, HTR2A, HTR2B, PTPN1, SRC 2.96932
[BP] GO:0030335 positive regulation of cell migration DRD1, EGFR, F10, F3, IGF1R, KDR, MET, MMP9, SRC 2.95051
[BP] GO:0071702 None ADORA1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, DRD3, FABP3, MMP12, PPARA, SIGMAR1 2.93291
[BP] GO:0030003 cellular cation homeostasis ADRA1A, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, EPHX2, HTR2A, HTR2B 2.91691
[BP] GO:0001963 None DRD1, DRD2, DRD3 2.89648
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA1A, AURKB, CDC25B, DRD1, DRD2, DRD3, EGFR, EPHX2, ERBB2, F3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SRC, XDH 2.8558
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA1A, CYP19A1, DRD1, DRD2, DRD3, EGFR, ERBB2, IGF1R, MET, MMP12, MMP9, PPARA, PTPN1, SRC, XDH 2.85234
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, KDR, SRC 2.85123
[BP] GO:0043549 regulation of kinase activity ADORA1, CDC25B, DRD2, EGFR, ERBB2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, PTPN1, SRC 2.85047
[BP] GO:2000147 positive regulation of cell motility DRD1, EGFR, F10, F3, IGF1R, KDR, MET, MMP9, SRC 2.85047
[BP] GO:0042752 None ADORA1, DRD2, DRD3, PPARA, RORC 2.8461
[BP] GO:0006873 cellular ion homeostasis ADRA1A, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, EPHX2, HTR2A, HTR2B 2.84307
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, EGFR, ERBB2, FLT3, HTR2A, HTR2B, PTPN1, SRC 2.83088
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, EGFR, HTR2B, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC 2.83088
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA1A, ADRB1, AXL, CA2, CACNA1C, CYP1B1, DRD2, DRD3, EGFR, ERBB2, F3, HCAR2, HTR2A, HTR2B, KDR, MET, MMP12, MMP9, PIM1, SRC, XDH 2.83088
[BP] GO:0071071 None FABP3, HTR2A, HTR2B 2.83088
[BP] GO:0032225 None DRD1, DRD2, DRD3 2.83088
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1B1, CYP2A13, CYP2A6, CYP2D6, EPHX2 2.81675
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CYP1B1, CYP2D6, DRD2, DRD3, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC 2.81254
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, DRD3, EGFR, HTR1A 2.81227
[BP] GO:0010518 positive regulation of phospholipase activity ADRA1A, EGFR, HTR2A, HTR2B 2.80707
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HTR2A, MET, SRC 2.80707
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HTR2A, MET, SRC 2.80707
[BP] GO:0030260 entry into host cell AXL, EGFR, HTR2A, MET, SRC 2.80707
[BP] GO:0044409 entry into host AXL, EGFR, HTR2A, MET, SRC 2.80707
[BP] GO:1903532 None ACHE, CYP19A1, DRD2, EGFR, HCAR2, HTR2B, MMP12, SRC 2.80528
[BP] GO:0051338 regulation of transferase activity ADORA1, AURKB, CDC25B, DRD2, EGFR, ERBB2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, PTPN1, SRC 2.7989
[BP] GO:0051272 positive regulation of cellular component movement DRD1, EGFR, F10, F3, IGF1R, KDR, MET, MMP9, SRC 2.78544
[BP] GO:0097755 None ADRB1, DRD1, EGFR, EPHX2 2.77937
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 2.76833
[BP] GO:0050679 None EGFR, ERBB2, F3, HTR2B, KDR, MMP12 2.75583
[BP] GO:0003012 None ADORA1, ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7 2.73454
[BP] GO:0044236 multicellular organism metabolic process ADRB1, MMP1, MMP12, MMP2, MMP9 2.71802
[BP] GO:0009611 response to wounding ACHE, ADORA3, DRD2, EGFR, ERBB2, PPARA 2.70639
[BP] GO:0043269 regulation of ion transport ADORA1, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, HTR1A, HTR2A, MMP9 2.70639
[BP] GO:0014821 None DRD1, DRD2, HTR2B 2.69948
[BP] GO:0040017 positive regulation of locomotion DRD1, EGFR, F10, F3, IGF1R, KDR, MET, MMP9, SRC 2.67838
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA1A, CDC25B, DRD2, EGFR, ERBB2, FLT3, HTR2A, HTR2B, KDR, MMP9, PTPN1, SRC, XDH 2.67192
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, AXL, CYP1B1, DRD1, EGFR, ERBB2, FABP4, FLT3, IGF1R, KDR, MMP2, RORC, SRC 2.64182
[BP] GO:0044093 positive regulation of molecular function ADORA1, ADRA1A, ADRB1, AURKB, CDC25B, DRD2, EGFR, ERBB2, F3, FLT3, HTR2A, HTR2B, MET, MMP9, PTPN1, SRC, XDH 2.64171
[BP] GO:0003008 None ADORA1, ADRA1A, ADRB1, AKR1B1, CYP1B1, DRD1, DRD2, DRD3, EGFR, EPHX2, HTR1A, HTR2A, HTR2B, HTR7, SRC 2.64171
[BP] GO:0045187 None ADORA1, DRD2, DRD3 2.63721
[BP] GO:0031623 None ACHE, DRD2, DRD3, HTR2B 2.63721
[BP] GO:0032922 None DRD2, DRD3, PPARA, RORC 2.63721
[BP] GO:0001996 None ADRA1A, ADRB1 2.63721
[BP] GO:0060160 None DRD2, DRD3 2.63721
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.63721
[BP] GO:0003099 None ADRA1A, ADRB1 2.63721
[BP] GO:0010243 response to organonitrogen compound AKR1B1, DRD1, DRD2, DRD3, EGFR, FABP3, FLT3, IGF1R, MMP2, PPARA, SRC 2.63543
[BP] GO:0006874 cellular calcium ion homeostasis ADRA1A, CACNA1C, DRD1, DRD2, DRD3, EPHX2, HTR2A, HTR2B 2.63277
[BP] GO:0051282 None CACNA1C, DRD1, DRD2, HTR2A, HTR2B 2.61256
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, EGFR, ERBB2, FLT3, HTR2A, HTR2B, IGF1R, PTPN1, SRC 2.59942
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA1A, ADRB1, AKR1B1, AURKB, AXL, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, EGFR, ERBB2, FABP3, FABP4, HCAR2, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, XDH 2.59942
[BP] GO:0006805 xenobiotic metabolic process CYP1B1, CYP2A13, CYP2D6, EPHX2, RORC 2.59849
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, DRD1, EGFR, KDR, SRC 2.5901
[BP] GO:0035813 None ADORA1, DRD2, DRD3 2.5901
[BP] GO:0071880 None ADRA1A, ADRB1, DRD2 2.5901
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, AURKB, AXL, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, EGFR, ERBB2, FABP3, FABP4, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, XDH 2.58992
[BP] GO:0031399 regulation of protein modification process ADORA1, ADRA1A, CDC25B, DRD1, DRD2, EGFR, ERBB2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, MMP9, PTPN1, SRC, XDH 2.58911
[BP] GO:0055074 calcium ion homeostasis ADRA1A, CACNA1C, DRD1, DRD2, DRD3, EPHX2, HTR2A, HTR2B 2.55441
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 2.55295
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRA1A, ADRB1, AURKB, CDC25B, DRD2, EGFR, ERBB2, F3, FLT3, HTR2A, HTR2B, PTPN1, SRC, XDH 2.55094
[BP] GO:0010517 regulation of phospholipase activity ADRA1A, EGFR, HTR2A, HTR2B 2.54752
[BP] GO:0051223 None ACHE, CACNA1C, DRD2, DRD3, EGFR, ERBB2, HCAR2, HTR2B, MMP12, PTPN1, SRC 2.54706
[BP] GO:0042749 None ADORA1, DRD2, DRD3 2.53672
[BP] GO:1902532 negative regulation of intracellular signal transduction ADRA1A, DRD2, DRD3, IGF1R, MET, MMP9, PTPN1, SRC, XDH 2.52917
[BP] GO:0072503 cellular divalent inorganic cation homeostasis ADRA1A, CACNA1C, DRD1, DRD2, DRD3, EPHX2, HTR2A, HTR2B 2.52528
[BP] GO:0048015 phosphatidylinositol-mediated signaling ERBB2, HTR2A, HTR2B, IGF1R 2.49882
[BP] GO:0055082 cellular chemical homeostasis ADRA1A, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, EPHX2, HTR2A, HTR2B 2.49882
[BP] GO:0009891 positive regulation of biosynthetic process ADRB1, AURKB, DRD1, DRD2, DRD3, EGFR, ERBB2, FABP3, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, PPARA, RORC, SRC 2.48983
[BP] GO:0060193 positive regulation of lipase activity ADRA1A, EGFR, HTR2A, HTR2B 2.47458
[BP] GO:0044062 None ADORA1, DRD2, DRD3 2.42523
[BP] GO:0048017 inositol lipid-mediated signaling ERBB2, HTR2A, HTR2B, IGF1R 2.42287
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.39768
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.38035
[BP] GO:1901698 response to nitrogen compound AKR1B1, DRD1, DRD2, DRD3, EGFR, FABP3, FLT3, IGF1R, MMP2, PPARA, SRC 2.3749
[BP] GO:0071875 None ADRA1A, ADRB1, DRD2 2.3749
[BP] GO:0055065 metal ion homeostasis ADRA1A, CACNA1C, DRD1, DRD2, DRD3, EGFR, EPHX2, HTR2A, HTR2B 2.36984
[BP] GO:0070201 None ACHE, CACNA1C, DRD2, DRD3, EGFR, ERBB2, HCAR2, HTR2B, MMP12, PTPN1, SRC 2.36379
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, AXL, CYP1B1, DRD1, EGFR, ERBB2, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, RORC, SRC 2.35746
[BP] GO:0015908 None DRD2, DRD3, FABP3, PPARA 2.35513
[BP] GO:0006936 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7 2.34563
[BP] GO:0032465 None AURKB, CDC25B, DRD2, DRD3 2.33246
[BP] GO:0016310 phosphorylation AURKB, AXL, CDC25B, DRD1, EGFR, ERBB2, FLT3, HTR2B, IGF1R, KDR, MET, PIM1, SRC 2.31379
[BP] GO:1903524 None ADRA1A, ADRB1, EGFR, HTR2A 2.28568
[BP] GO:0023052 None ADORA1, ADRA1A, ADRB1, CACNA1C, DRD1, DRD2, DRD3, HTR2A, HTR6, HTR7 2.28244
[BP] GO:0001975 None DRD1, DRD2, DRD3 2.28244
[BP] GO:0030534 None DRD1, DRD2, DRD3, HTR2A, PPARA 2.22463
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.22182
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRA1A, CDC25B, DRD2, EGFR, ERBB2, F3, FLT3, HTR2A, HTR2B, KDR, MMP9, PTPN1, SRC, XDH 2.22182
[BP] GO:0043271 negative regulation of ion transport ADORA1, DRD2, DRD3, HTR2A, MMP9 2.21384
[BP] GO:0050678 None EGFR, ERBB2, F3, HTR2B, KDR, MMP12, XDH 2.2127
[BP] GO:0042417 None DRD1, DRD2, DRD3 2.1951
[BP] GO:0014059 None DRD2, DRD3, HTR2A 2.1951
[BP] GO:0051302 None AURKB, CDC25B, DRD2, DRD3, HTR2B 2.1951
[BP] GO:0021853 None DRD1, DRD2 2.1951
[BP] GO:0010641 None F3, SRC 2.1951
[BP] GO:0007598 None F10, F3 2.1951
[BP] GO:1904936 None DRD1, DRD2 2.1951
[BP] GO:0042321 None ADORA1, DRD2 2.1951
[BP] GO:0090325 None DRD2, DRD3 2.1951
[BP] GO:0010513 None HTR2A, HTR2B 2.1951
[BP] GO:0050730 None ADORA1, EGFR, FLT3, HTR2A, PTPN1, SRC 2.19113
[BP] GO:0007154 None ADORA1, ADRA1A, ADRB1, AXL, CACNA1C, DRD1, DRD2, DRD3, HTR2A, HTR6, HTR7 2.19113
[BP] GO:0033993 response to lipid ALPL, AXL, CA2, CA9, EGFR, FABP3, FLT3, HTR5A, RORC, SRC 2.18925
[BP] GO:0032845 None ADORA1, DRD2, HTR2A, HTR2B, SRC 2.18925
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9 2.1748
[BP] GO:1900542 None ADRB1, DRD1, DRD2, DRD3, HTR2A, PPARA 2.16588
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, DRD1, EGFR, ERBB2, F10, FLT3, IGF1R, KDR, MET, SRC 2.15767
[BP] GO:0006928 movement of cell or subcellular component AXL, CYP1B1, DRD1, DRD2, EGFR, ERBB2, FUT7, HTR2B, HTR6, KDR, MMP1, MMP12, MMP9, SRC 2.14123
[BP] GO:0008016 None ADORA1, ADORA3, ADRA1A, ADRB1, CACNA1C, DRD2 2.1404
[BP] GO:0006979 response to oxidative stress AKR1B1, AXL, CA3, CYP1B1, EGFR, MMP9, SRC 2.13419
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, ADRA1A, AKR1B1, ALPL, AXL, CA2, CACNA1C, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, ERBB2, FLT3, HTR5A, KDR, MMP9, PIM1, PPARA, RORC, SIGMAR1, SRC 2.12348
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.11892
[BP] GO:0006140 None ADRB1, DRD1, DRD2, DRD3, HTR2A, PPARA 2.10545
[BP] GO:0045744 None DRD2, DRD3, MET 2.08763
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.08146
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, CYP1B1, DRD1, EGFR, FLT3, RORC, SRC 2.08054
[BP] GO:0031328 positive regulation of cellular biosynthetic process ADRB1, AURKB, DRD1, DRD2, DRD3, EGFR, ERBB2, FABP3, HTR2A, HTR2B, IGF1R, MET, MMP12, PPARA, RORC, SRC 2.07841
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1B1, CYP2A6, CYP2D6 2.0574
[BP] GO:0098801 None ADORA1, DRD2, DRD3 2.0574
[BP] GO:0042596 None ADRB1, DRD1, HTR1A 2.0574
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CYP1B1, DRD1, EGFR, IGF1R, MMP2, MMP9, RORC, SRC 2.0574
[BP] GO:0007204 positive regulation of cytosolic calcium ion concentration ADRA1A, CACNA1C, DRD1, DRD2, HTR2A, HTR2B 2.0574
[BP] GO:0021843 None DRD1, DRD2 2.0574
[BP] GO:0021830 None DRD1, DRD2 2.0574
[BP] GO:0003057 None ADRA1A, ADRB1 2.0574
[BP] GO:0021826 None DRD1, DRD2 2.0574
[BP] GO:0032787 None ALOX5, CYP1B1, CYP2A13, CYP2A6, CYP2D6, EPHX2, FABP3, PPARA 2.05245
[BP] GO:0051222 positive regulation of protein transport ACHE, DRD2, EGFR, ERBB2, HCAR2, HTR2B, MMP12, SRC 2.04119
[BP] GO:0051701 interaction with host AXL, EGFR, HTR2A, MET, SRC 2.03619
[BP] GO:0045907 None ADRA1A, EGFR, HTR2A 2.02942
[BP] GO:0060191 regulation of lipase activity ADRA1A, EGFR, HTR2A, HTR2B 2.02425
[BP] GO:0006875 cellular metal ion homeostasis ADRA1A, CACNA1C, DRD1, DRD2, DRD3, EPHX2, HTR2A, HTR2B 2.02218
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA1A, CDC25B, DRD2, EGFR, ERBB2, F3, FLT3, HTR2A, HTR2B, KDR, MMP9, PTPN1, SRC, XDH 2.01294
[BP] GO:0044259 multicellular organismal macromolecule metabolic process MMP1, MMP12, MMP2, MMP9 2.00792
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA1A, ADRB1, AXL, CA4, DRD1, DRD2, DRD3, F10, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1 6.59315
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ADRA1A, ADRB1, AXL, CA2, CA4, CA9, CACNA1C, DRD1, DRD2, DRD3, EGFR, ERBB2, F10, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1, SRC 5.90046
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRA1A, ADRB1, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, DRD1, DRD2, DRD3, EGFR, ERBB2, F10, F3, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP2, PIM1, PTPN1, SRC 5.26656
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRA1A, ADRB1, AXL, DRD1, DRD2, DRD3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1 4.83084
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ADRA1A, ADRB1, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CYP19A1, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, EGFR, ERBB2, F10, F3, FLT3, FUT7, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PTPN1, SIGMAR1, SRC 3.39598
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRA1A, ADRB1, ALOX5, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CYP19A1, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, EGFR, ERBB2, F10, F3, FLT3, FUT7, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP2, PIM1, PTPN1, SIGMAR1, SRC 3.10643
[CC] GO:0098590 plasma membrane region ADORA1, ADRA1A, CA2, CA4, CA9, DRD1, DRD2, EGFR, ERBB2, HTR2A, MET, SIGMAR1, SRC 2.92255
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, ERBB2 2.63543
[CC] GO:0031233 None CA4, F10, F3 2.5901
[CC] GO:0031224 None ACHE, ADORA1, ADORA3, ADRA1A, ADRB1, ALPL, AXL, CA12, CA14, CA4, CA9, CACNA1C, DRD1, DRD2, DRD3, EGFR, ERBB2, F10, F3, FLT3, FUT7, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1 2.28389
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.0574
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 20.2845
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 12.9867
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 11.493
[MF] GO:0046914 transition metal ion binding ALOX5, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1B1, CYP2A13, CYP2A6, CYP2D6, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, XDH 11.4599
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, EGFR, EPHX2, ERBB2, F10, F3, FABP3, FABP4, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, XDH 11.4599
[MF] GO:0008227 None ADRA1A, ADRB1, DRD2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 9.39906
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA1A, ADRB1, AXL, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PPARA, RORC, SIGMAR1 9.22834
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, EPHX2, F10, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, XDH 8.64695
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR7 8.49747
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRA1A, ADRB1, AXL, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1 8.37818
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRA1A, ADRB1, AXL, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1 8.37818
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA1A, ADRB1, AXL, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PPARA, RORC, SIGMAR1 8.26846
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA1A, ADRB1, AXL, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PPARA, RORC, SIGMAR1 8.05374
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 7.83447
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA1A, ADRB1, AXL, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PPARA, RORC, SIGMAR1 7.51572
[MF] GO:0030594 None DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.25751
[MF] GO:0004993 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.12255
[MF] GO:0099589 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.12255
[MF] GO:0043176 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 7.08031
[MF] GO:0051378 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 7.08031
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CYP19A1, CYP1B1, CYP2A13, CYP2A6, CYP2D6, EGFR, EPHX2, ERBB2, F10, F3, FLT3, FUT7, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTPN1, SRC, XDH 6.84908
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC 6.57992
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET 6.29411
[MF] GO:0099528 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.03009
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET 5.65442
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CYP19A1, CYP1B1, CYP2A13, CYP2D6, DRD1, DRD2, DRD3, EGFR, ERBB2, FLT3, HTR2A, HTR2B, IGF1R, KDR, MET, PIM1, PPARA, SIGMAR1, SRC 5.46034
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR2A, HTR2B, HTR5A, HTR7 5.28083
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1B1, CYP2A13, CYP2A6, CYP2D6 5.24515
[MF] GO:0004930 None ADORA1, ADORA3, ADRA1A, ADRB1, DRD1, DRD2, DRD3, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1 4.67466
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, SRC 4.56245
[MF] GO:1901338 None ADRB1, DRD1, DRD2, DRD3 4.07549
[MF] GO:0070330 aromatase activity CYP19A1, CYP1B1, CYP2A13, CYP2D6 3.85468
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1B1, CYP2A13, CYP2A6, CYP2D6, XDH 3.85468
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1B1, CYP2A13, CYP2A6, CYP2D6, EPHX2, F10, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, XDH 3.767
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, ERBB2, KDR 3.46997
[MF] GO:0020037 heme binding CYP19A1, CYP1B1, CYP2A13, CYP2A6, CYP2D6, SRC 3.3658
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP2A13, CYP2A6, CYP2D6 3.30957
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1B1, CYP2A13, CYP2A6, CYP2D6, SRC 3.21891
[MF] GO:0004952 None DRD1, DRD2, DRD3 3.14179
[MF] GO:0032403 protein complex binding ACHE, ADORA1, EGFR, FLT3, HTR2A, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SRC 3.09014
[MF] GO:0035240 None DRD1, DRD2, DRD3 3.05815
[MF] GO:0008389 None CYP2A13, CYP2A6 3.01319
[MF] GO:0016903 None AKR1B1, AKR1B10, ALDH2, XDH 2.94925
[MF] GO:0019825 oxygen binding CYP19A1, CYP1B1, CYP2A13, CYP2D6 2.91691
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1B1, CYP2A13, CYP2A6, CYP2D6 2.89812
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, EGFR, FLT3, HTR2A, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC 2.8891
[MF] GO:0004935 None ADRA1A, ADRB1, DRD2 2.83088
[MF] GO:0017171 serine hydrolase activity ACHE, F10, F3, MMP1, MMP12, MMP2, MMP9 2.58609
[MF] GO:0004672 protein kinase activity AURKB, AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.49882
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALDH2, ALOX5, CYP19A1, CYP1B1, CYP2A13, CYP2A6, CYP2D6, XDH 2.15542
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.08763
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1B1, CYP2A13, CYP2A6, CYP2D6 2.05808
[MF] GO:0004252 None F10, F3, MMP1, MMP12, MMP2, MMP9 2.0574
[MF] GO:0004064 arylesterase activity CA1, CA2 2.0574
[MF] GO:0048037 cofactor binding ALDH2, CYP19A1, CYP1B1, CYP2A13, CYP2A6, CYP2D6, SRC, XDH 2.03111


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA3, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 21.684
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 HTR2B, HTR1A, ADRB1, HTR2A, HTR5A, ADRA1A, HTR6, HTR7, ADORA3, ADORA1, DRD1, DRD2, DRD3 9.6834
Calcium signaling pathway_Homo sapiens_hsa04020 HTR6, HTR7, ERBB2, HTR2B, ADRB1, CACNA1C, HTR2A, DRD1, HTR5A, ADRA1A, EGFR 9.3516
Serotonergic synapse_Homo sapiens_hsa04726 HTR6, HTR7, CYP2D6, ALOX5, HTR2B, HTR1A, CACNA1C, HTR2A, HTR5A 8.5965
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, ERBB2, MMP9, EGFR 7.0504
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, HTR6, ADORA1, HTR1A, ADRB1, CACNA1C, DRD1, DRD2, PPARA 6.6214
Gap junction_Homo sapiens_hsa04540 SRC, HTR2B, ADRB1, HTR2A, DRD1, DRD2, EGFR 6.6214
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, ERBB2, KDR, MMP9, MET, EGFR, IGF1R 5.433
Adherens junction_Homo sapiens_hsa04520 PTPN1, SRC, ERBB2, MET, EGFR, IGF1R 5.6747
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, ERBB2, MMP9, MET, EGFR, IGF1R 3.3669
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, CYP1B1, CYP19A1, IGF1R 3.5844
MicroRNAs in cancer_Homo sapiens_hsa05206 ERBB2, PIM1, CYP1B1, MMP9, MET, EGFR, CDC25B 3.3469
Focal adhesion_Homo sapiens_hsa04510 SRC, ERBB2, KDR, MET, EGFR, IGF1R 3.3469
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, DRD2, MET, EGFR, IGF1R 3.2737
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, ERBB2, MET, EGFR 3.2557
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, ADRB1, MET, EGFR, IGF1R 2.9172
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1, ADRB1, CACNA1C, ADRA1A 2.8976
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP2A6, CYP2A13, CYP2D6, CYP1B1 3.1639
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.2335
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, CACNA1C, EGFR 2.8976
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, EGFR 2.7828
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, KDR, MET, EGFR, IGF1R 2.3954
Dopaminergic synapse_Homo sapiens_hsa04728 CACNA1C, DRD1, DRD2, DRD3 2.3954
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1, ADRB1 2.3954
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.1631
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, ALDH2, AKR1B1 2.3508
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.2025
Renin secretion_Homo sapiens_hsa04924 ADORA1, ADRB1, CACNA1C 2.2636
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.9714
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1, F3 1.8271
Prostate cancer_Homo sapiens_hsa05215 ERBB2, EGFR, IGF1R 1.9492
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, HTR2B, HTR2A 1.8435
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, ERBB2, EGFR 1.9646
Metabolic pathways_Homo sapiens_hsa01100 CYP2A6, FUT7, AKR1B10, ALDH2, ALOX5, EPHX2, ALPL, AKR1B1, CYP19A1, XDH 1.7567
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP2A6, CYP2A13, CYP1B1 1.9978
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, ALDH2, AKR1B1 2.8976
HIF-1 signaling pathway_Homo sapiens_hsa04066 ERBB2, EGFR, IGF1R 1.8176
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.5058
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 ADRB1, CACNA1C, ADRA1A 1.4564
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, CACNA1C, EGFR 1.4077
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 KDR, MET, EGFR, IGF1R 1.2619
MAPK signaling pathway_Homo sapiens_hsa04010 CACNA1C, EGFR, CDC25B 1.0284
Non-small cell lung cancer_Homo sapiens_hsa05223 ERBB2, EGFR 1.4077
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.0942
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.3308
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.3664
Taste transduction_Homo sapiens_hsa04742 HTR1A, CACNA1C 1.1926
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, CACNA1C 1.0219
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 1.0284
Endometrial cancer_Homo sapiens_hsa05213 ERBB2, EGFR 1.4546
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.4054
Pancreatic cancer_Homo sapiens_hsa05212 ERBB2, EGFR 1.3262
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 1.1528
Amphetamine addiction_Homo sapiens_hsa05031 CACNA1C, DRD1 1.3218
Salivary secretion_Homo sapiens_hsa04970 ADRB1, ADRA1A 1.1506
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 1.1463
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.221
Dilated cardiomyopathy_Homo sapiens_hsa05414 ADRB1, CACNA1C 1.1484
Hepatitis B_Homo sapiens_hsa05161 SRC, MMP9 0.8649
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.9796
FoxO signaling pathway_Homo sapiens_hsa04068 EGFR, IGF1R 0.9183
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.8801
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9805
AMPK signaling pathway_Homo sapiens_hsa04152 ADRA1A, IGF1R 0.9602
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.9183
Vascular smooth muscle contraction_Homo sapiens_hsa04270 CACNA1C, ADRA1A 0.9796
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.218
Peroxisome_Homo sapiens_hsa04146 EPHX2, XDH 1.1926
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP2D6 1.3054
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.7567
Cocaine addiction_Homo sapiens_hsa05030 DRD1, DRD2 1.4852
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.6639
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, EPHX2 1.3614
Steroid hormone biosynthesis_Homo sapiens_hsa00140 CYP1B1, CYP19A1 1.3996
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3206
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.5183
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3597
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3592
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3464
Alzheimer's disease_Homo sapiens_hsa05010 CACNA1C 0.3718
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.3891
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.4012
Tight junction_Homo sapiens_hsa04530 SRC 0.4199
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.4199
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 IGF1R 0.4158
Phospholipase D signaling pathway_Homo sapiens_hsa04072 EGFR 0.4142
Platelet activation_Homo sapiens_hsa04611 SRC 0.45
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.45
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4725
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.45
Axon guidance_Homo sapiens_hsa04360 MET 0.4449
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.4575
Glutamatergic synapse_Homo sapiens_hsa04724 CACNA1C 0.4631
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.4575
Tryptophan metabolism_Homo sapiens_hsa00380 ALDH2, CYP1B1 1.6256
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.5003
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5003
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5085
Circadian entrainment_Homo sapiens_hsa04713 CACNA1C 0.5085
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5085
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CACNA1C 0.5003
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5082
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5176
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5223
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.5317
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.5421
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.5715
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.5527
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.5367
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.569
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5743
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5889
Long-term potentiation_Homo sapiens_hsa04720 CACNA1C 0.5889
Bile secretion_Homo sapiens_hsa04976 CA2 0.5728
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5889
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8271
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.569
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6 0.5889
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6003
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.5889
Shigellosis_Homo sapiens_hsa05131 SRC 0.5889
Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 ALDH2 0.5872
Lysine degradation_Homo sapiens_hsa00310 ALDH2 0.6527
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.794
Malaria_Homo sapiens_hsa05144 MET 0.6639
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9817
Type II diabetes mellitus_Homo sapiens_hsa04930 CACNA1C 0.6664
Arginine and proline metabolism_Homo sapiens_hsa00330 ALDH2 0.6639
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 ALDH2 0.6664
Fatty acid degradation_Homo sapiens_hsa00071 ALDH2 0.6919
Pyruvate metabolism_Homo sapiens_hsa00620 ALDH2 0.7258
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8626
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8207
beta-Alanine metabolism_Homo sapiens_hsa00410 ALDH2 0.8207
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8626
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8242
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8626
Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 ALDH2 0.8626
Histidine metabolism_Homo sapiens_hsa00340 ALDH2 0.8801
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0476
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, XDH 3.119


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)