TCM Prescription: Gu Shu Kang Capsule



Prescription Description
Prescription IDTCMF750
Pinyin NameGu Shu Kang Jiao Nang 
Chinese Name骨疏康胶囊
English NameGu Shu Kang Capsule
Function Description原发性骨质疏松症
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with IndicationSkeletalMuscle
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2507 Epimedium brevicornum 淫羊藿 TCMH2507 AY362429
TCMH1966 Rehmannia glutinosa 熟地黄 TCMH1966 ITSAH4578-14
TCMH700 Drynaria fortunei 骨碎补 TCMH700 GBVM3977-11
TCMH981 Astragalus membranaceus 黄芪 TCMH981 ITSAK2981-14
TCMH407 Salvia miltiorrhiza 丹参 TCMH407 ITSAH2408-14
TCMH1515 Auricularia auricula 木耳 TCMH1515 GBSO13455-15
TCMH960 NA 黄瓜子 TCMH960
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT211 CES1 Acyl coenzyme A:cholesterol acyltransferase Transferase P23141
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT633 SLC6A4 Serotonin transporter Transporter P31645
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718
TCMT974 GPER1 G-protein coupled estrogen receptor 1 GPCR Q99527
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1168 Trichomonas vaginalis
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1405 Penicillium citrinum
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0042221 response to chemical ADRA2A, AKR1B1, ALPL, AR, AXL, CA2, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, GPER1, HSD17B2, IGF1R, KCNH2, KDR, MMP2, MMP9, PPARA, RORC, SLC6A2, SLC6A4, SRC, TERT, TYR 8.14407
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, PPARA 7.57056
[BP] GO:0033993 response to lipid ALPL, AR, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, GPER1, HSD17B2, RORC, SLC6A4, SRC, TYR 7.47097
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AR, AXL, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, GPER1, HSD17B2, IGF1R, MMP2, MMP9, PPARA, RORC, SLC6A4, SRC, TYR 7.21039
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA2A, AKR1B1, AR, CDC25B, CSNK2A1, CYP1B1, ESR1, ESRRA, FABP3, FLT3, GPER1, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, SLC6A4, SRC, TERT, XDH 6.99182
[BP] GO:0010033 response to organic substance ADRA2A, AKR1B1, ALPL, AR, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, GPER1, HSD17B2, IGF1R, KDR, MMP2, PPARA, RORC, SLC6A4, SRC, TYR 6.92933
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PIM1, PPARA, RORC, SRC 6.90349
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CES1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, HSD17B1, HSD17B2 6.77373
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PPARA, RORC, SRC 6.75106
[BP] GO:0009725 response to hormone ADRA2A, AKR1B1, ALPL, AR, CA2, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, GPER1, PPARA, SLC6A4, SRC 6.24058
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, ALPL, AR, AXL, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GPER1, IGF1R, KCNH2, KDR, MMP2, MMP9, RORC, SLC6A4, SRC, TERT 6.24058
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TYR, XDH 6.19023
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA2A, AKR1B1, AR, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, GPER1, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, XDH 6.19023
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, FUT7, PIM1, PPARA, TYR, XDH 5.99954
[BP] GO:0009755 hormone-mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PPARA, RORC, SRC 5.92315
[BP] GO:0014070 response to organic cyclic compound ALPL, AR, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, GPER1, RORC, SLC6A4, SRC, TYR 5.81224
[BP] GO:0009719 response to endogenous stimulus ADRA2A, AKR1B1, ALPL, AR, CA2, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, GPER1, IGF1R, MMP2, PPARA, SLC6A4, SRC 5.81224
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA2A, AKR1B1, AKR1B10, ALOX5, ALPL, AR, AXL, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, FABP4, GPER1, HSD17B2, IGF1R, KCNH2, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RORC, SLC6A2, SLC6A4, SRC, TYR 5.63317
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7 5.62589
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP1, MMP2, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TYR, XDH 5.56124
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA2A, AKR1B1, AR, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FABP4, FLT3, GPER1, HSD17B1, HSD17B2, KCNH2, KDR, MET, PPARA, SLC6A2, SLC6A4, SRC, TERT, XDH 5.30037
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA2A, AKR1B1, AR, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GPER1, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, XDH 5.2893
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, TYR 5.28038
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 5.06857
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GPER1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, XDH 4.93658
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA2A, AKR1B1, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GPER1, KDR, MET, MMP12, MMP9, PTPN1, SRC, TERT, XDH 4.91701
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA2A, AKR1B1, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GPER1, KDR, MET, MMP12, MMP9, PTPN1, SRC, TERT, XDH 4.91605
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, FABP4, FUT7, MMP1, MMP12, MMP2, MMP9, SRC, XDH 4.91605
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, AR, CDC25B, CSNK2A1, ESR1, FLT3, GPER1, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, TERT 4.84811
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.82599
[BP] GO:0048513 animal organ development ACHE, AR, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, KDR, PPARA, SRC, TYR 4.80734
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALPL, AR, AURKB, AXL, CA2, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, GPER1, HSD17B2, IGF1R, KCNH2, KDR, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, SRC, TERT, TYR 4.79783
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GPER1, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC, TERT, XDH 4.78773
[BP] GO:0006805 xenobiotic metabolic process CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, RORC 4.70154
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, ALPL, AR, AXL, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, GPER1, IGF1R, KDR, MMP2, RORC, SLC6A4, SRC 4.68694
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7 4.54318
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.54134
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, AR, CYP1A1, CYP1B1, ESR1, FLT3, GPER1, RORC, SLC6A4, SRC 4.53371
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TERT 4.53275
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CES1, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, FABP4, FUT7, MET, PPARA 4.46441
[BP] GO:0010035 response to inorganic substance AKR1B1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, SRC, TERT 4.46046
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, AR, AURKB, AXL, CA2, CDC25B, CES1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, HSD17B2, KDR, MET, MMP2, MMP9, PIM1, PPARA, RORC, SLC6A4, SRC, TERT, TYR 4.3955
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, ALPL, AR, AURKB, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GPER1, IGF1R, KCNH2, KDR, MMP2, MMP9, PTPN1, RORC, SLC6A4, SRC, TERT 4.34322
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPER1, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, XDH 4.30188
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC, TERT 4.24207
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GPER1, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, TERT, XDH 4.22301
[BP] GO:0006631 fatty acid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, PPARA 4.18518
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADRA2A, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, GPER1, HSD17B1, HSD17B2 4.11597
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AR, AURKB, AXL, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TERT, TYR, XDH 3.92525
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 3.92525
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19 3.92407
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 3.89559
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ADRA2A, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, GPER1, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SRC, TERT 3.78625
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA2A, AR, ESR1, ESR2, GPER1, IGF1R, MET, MMP12, MMP9, PTPN1, SLC6A4, SRC, TERT, XDH 3.78538
[BP] GO:0006690 icosanoid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19 3.77835
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA2A, AR, ESR1, ESR2, GPER1, IGF1R, MET, MMP12, MMP9, PTPN1, SLC6A4, SRC, TERT, XDH 3.77835
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.72995
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA2A, AKR1B1, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, GPER1, IGF1R, KDR, MET, MMP12, MMP9, PTPN1, SLC6A4, SRC, TERT, XDH 3.65633
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, TERT 3.6072
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA2A, AKR1B1, AR, AXL, CSNK2A1, CYP1B1, FLT3, GPER1, KDR, MET, MMP12, MMP9, PTPN1, SRC, TERT, XDH 3.58075
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA2A, AKR1B1, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, GPER1, IGF1R, KDR, MET, MMP12, MMP9, PTPN1, SLC6A4, SRC, TERT, XDH 3.57495
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, ADRA2A, CYP1A1, FABP3, FLT3, GPER1, PPARA, RORC, SRC 3.57495
[BP] GO:0042592 homeostatic process ADORA1, ADRA2A, AKR1B1, AXL, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, GPER1, KCNH2, MET, SRC, TERT 3.50726
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, HSD17B1, HSD17B2, TYR, XDH 3.42042
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AR, AXL, CYP1B1, ESR1, GPER1, IGF1R, MMP2, MMP9, RORC, SLC6A4, SRC 3.41257
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.39684
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA2A, AKR1B1, AR, AXL, CSNK2A1, CYP1B1, ESRRA, FABP4, FLT3, GPER1, KDR, MET, MMP12, MMP2, MMP9, PTPN1, SRC, TERT, XDH 3.3409
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA2A, AR, AURKB, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, GPER1, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, XDH 3.34047
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA2A, AR, AURKB, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, XDH 3.33265
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ADRA2A, CYP19A1, CYP1B1, GPER1, IGF1R, KDR, MET, MMP9, SRC, TERT 3.32777
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPER1, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, XDH 3.32412
[BP] GO:0006352 DNA-templated transcription, initiation AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 3.30299
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, CES1, CYP1A1, CYP1B1, KDR, SLC6A4, SRC 3.27421
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA2A, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GPER1, IGF1R, KDR, MET, MMP9, PTPN1, SRC, XDH 3.23552
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AR, AURKB, AXL, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TERT, TYR, XDH 3.18572
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway AR, ESR1, ESR2, GPER1, SRC 3.16635
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA2A, AR, AURKB, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SRC, TERT, XDH 3.11986
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 3.1065
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA2A, AR, CYP19A1, ESR1, ESR2, GPER1, IGF1R, MET, MMP12, MMP9, PPARA, PTPN1, SRC, TERT, XDH 3.10209
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ADRA2A, CYP19A1, CYP1B1, GPER1, IGF1R, KDR, MET, MMP9, SRC, TERT 3.1008
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA2A, AKR1B1, AR, AXL, CYP1B1, FLT3, GPER1, KDR, MET, PTPN1, SRC, XDH 3.1008
[BP] GO:0045742 None ADORA1, ADRA2A, GPER1, MMP9 3.0973
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, AR, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, KDR, MMP9, PIM1, PPARA, RORC, SRC, TYR 3.02022
[BP] GO:1901186 None ADORA1, ADRA2A, GPER1, MMP9 3.01518
[BP] GO:1904705 regulation of vascular smooth muscle cell proliferation GPER1, MMP2, MMP9, TERT 3.01518
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRA2A, AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC 3.00005
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19 2.95097
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.91795
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA2A, AR, AURKB, CDC25B, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, GPER1, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SRC, TERT, XDH 2.89557
[BP] GO:0009115 None AOX1, XDH 2.83359
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.83143
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ADRA2A, CYP19A1, CYP1B1, GPER1, IGF1R, KDR, MET, MMP9, SRC, TERT 2.81126
[BP] GO:0071396 cellular response to lipid AR, AXL, ESR1, FLT3, GPER1, RORC, SLC6A4, SRC 2.80969
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ADRA2A, CYP19A1, CYP1B1, GPER1, IGF1R, KDR, MET, MMP9, SRC, TERT 2.80325
[BP] GO:0032787 None ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, PPARA 2.77049
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, MMP2, PPARA, SLC6A4, SRC, TERT 2.75553
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, MMP2, PPARA, SLC6A4, SRC, TERT 2.67956
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.67568
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.65451
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.65139
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA2A, AR, CDC25B, ESRRB, FABP3, FLT3, GPER1, KDR, MMP9, PTPN1, SRC, XDH 2.63221
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA2A, AR, CDC25B, ESRRB, FABP3, FLT3, GPER1, KDR, MMP9, PTPN1, SRC, XDH 2.63221
[BP] GO:0080134 regulation of response to stress ADORA1, ADRA2A, CYP19A1, ESR1, FABP4, GPER1, IGF1R, MET, MMP12, MMP2, PPARA, PTPN1, SRC, TERT, XDH 2.62446
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19 2.62151
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.6097
[BP] GO:0010676 None ESRRB, GPER1, PPARA, SRC 2.6097
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA2A, AR, FLT3, GPER1, KDR, PTPN1, SRC, XDH 2.59973
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.58894
[BP] GO:0008283 cell proliferation ACHE, AR, AURKB, CYP1A1, ESR1, FLT3, MET, PIM1, SRC, TYR 2.56341
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2C19 2.56341
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.56341
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, ESR1, PPARA, RORC, SLC6A4, SRC 2.56341
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, ADRA2A, AXL, CA2, CYP19A1, GPER1, KCNH2, MMP12, SLC6A4, SRC, TERT 2.55225
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA2A, AR, CDC25B, ESRRB, FABP4, FLT3, GPER1, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 2.51962
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, MMP2, PPARA, SLC6A4, SRC, TERT 2.50383
[BP] GO:0046110 None AOX1, XDH 2.46301
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.46301
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA2A, AR, CDC25B, ESRRB, FLT3, GPER1, KDR, MMP9, PTPN1, SRC, XDH 2.45723
[BP] GO:0071495 cellular response to endogenous stimulus ADRA2A, AKR1B1, AR, ESR1, FLT3, GPER1, IGF1R, MMP2, SLC6A4, SRC 2.43505
[BP] GO:0010675 None ESRRB, GPER1, PPARA, RORC, SRC 2.42566
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA2A, AR, CDC25B, ESRRB, FABP3, FABP4, FLT3, GPER1, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 2.42566
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, FABP3, PPARA 2.41928
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRA2A, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, FABP4, FLT3, GPER1, IGF1R, KDR, MET, MMP12, MMP2, MMP9, PPARA, PTPN1, SRC, TERT, XDH 2.41533
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AR, AXL, CDC25B, CYP19A1, CYP1A1, ESR1, ESRRB, HSD17B2, MMP2, MMP9, SLC6A4, SRC 2.41533
[BP] GO:0043393 regulation of protein binding AURKB, MET, MMP9, PPARA, SRC, TERT 2.40778
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.40107
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA2A, AR, CDC25B, ESRRB, FABP3, FABP4, FLT3, GPER1, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 2.39816
[BP] GO:0032355 response to estradiol CYP1A2, ESR1, ESRRA, GPER1, SLC6A4 2.39434
[BP] GO:0009968 negative regulation of signal transduction ADRA2A, AR, ESR1, ESR2, GPER1, IGF1R, MET, MMP12, MMP9, PTPN1, SRC, TERT, XDH 2.39201
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, GPER1, KDR, SRC 2.38501
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19 2.38501
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CES1, CYP19A1, HSD17B1, HSD17B2 2.37084
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA2A, AR, AXL, CA2, CYP1B1, ESR1, ESRRA, ESRRB, GPER1, KCNH2, KDR, MET, MMP12, MMP9, PIM1, SLC6A4, SRC, TERT, XDH 2.37065
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.36276
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.36276
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, PIM1, PPARA, TYR 2.36064
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, GPER1, MMP2, MMP9, TERT 2.35007
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.3211
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.31247
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA2A, AR, FLT3, GPER1, IGF1R, KDR, PTPN1, SRC, XDH 2.30324
[BP] GO:0001101 response to acid chemical AKR1B1, FABP3, HSD17B2, KDR, MMP2, SLC6A4, SRC 2.29682
[BP] GO:0030335 positive regulation of cell migration ADRA2A, GPER1, IGF1R, KDR, MET, MMP9, SRC, TERT 2.29625
[BP] GO:0048545 response to steroid hormone ALPL, AR, CA2, FLT3, GPER1, SRC 2.2908
[BP] GO:0009891 positive regulation of biosynthetic process AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, GPER1, IGF1R, KDR, MET, MMP12, PPARA, RORC, SRC, TERT 2.26925
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.26925
[BP] GO:0045913 None ESRRB, GPER1, PPARA, SRC 2.26222
[BP] GO:0009892 negative regulation of metabolic process ADORA1, ADRA2A, AR, AURKB, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, GPER1, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SRC, TERT, XDH 2.25797
[BP] GO:0006145 None AOX1, XDH 2.25214
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.25214
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.25214
[BP] GO:0042493 response to drug AKR1B1, AXL, CYP1A1, CYP1B1, FABP3, KCNH2, KDR, SLC6A2, SLC6A4, SRC 2.24435
[BP] GO:2000147 positive regulation of cell motility ADRA2A, GPER1, IGF1R, KDR, MET, MMP9, SRC, TERT 2.21657
[BP] GO:0003006 developmental process involved in reproduction ALPL, AR, AXL, CDC25B, CYP19A1, ESR1, ESRRB, HSD17B2, SRC 2.18734
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.16734
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ADRA2A, AXL, CA2, CA7, CYP19A1, GPER1, KCNH2, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SRC, TERT 2.16183
[BP] GO:0071383 None AR, FLT3, GPER1, SRC 2.14839
[BP] GO:0051272 positive regulation of cellular component movement ADRA2A, GPER1, IGF1R, KDR, MET, MMP9, SRC, TERT 2.1442
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, GPER1, IGF1R, KDR, MET, MMP12, PPARA, RORC, SRC, TERT 2.14224
[BP] GO:0010243 response to organonitrogen compound AKR1B1, FABP3, FLT3, GPER1, IGF1R, MMP2, PPARA, SLC6A4, SRC, TYR 2.14224
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADRA2A, AURKB, CA2, CA7, GPER1, KDR, SRC 2.1248
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, TERT 2.11343
[BP] GO:0006468 protein phosphorylation AURKB, AXL, CDC25B, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIM1, SRC 2.08636
[BP] GO:0048878 chemical homeostasis ADRA2A, AKR1B1, CA12, CA2, CA7, ESR1, FABP3, FABP4, GPER1, KCNH2, MET 2.05547
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.05381
[BP] GO:0040017 positive regulation of locomotion ADRA2A, GPER1, IGF1R, KDR, MET, MMP9, SRC, TERT 2.05336
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA2A, AR, CDC25B, FLT3, GPER1, KDR, MMP9, PTPN1, SRC, XDH 2.05336
[BP] GO:0043436 oxoacid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, PIM1, PPARA, TYR 2.04863
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, ESR1, FABP4, GPER1, MMP12, MMP2, PPARA, PTPN1, SRC 2.03693
[BP] GO:0003018 None ADORA1, ADRA2A, GPER1, SLC6A4, SRC 2.03575
[BP] GO:0035265 organ growth AR, CYP19A1, ESR1 2.03575
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.02738
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GPER1, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, SRC, TERT, TYR, XDH 2.01044
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, GPER1, IGF1R, MET, MMP12, PPARA, PTPN1, RORC, SRC, TERT 2.00025
[CC] GO:0097443 sorting endosome KDR, PTPN1 1.94793
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRA2A, ALPL, AR, AXL, CA12, CA14, CA2, CA4, CSNK2A1, ESR1, FLT3, GPER1, IGF1R, KCNH2, KDR, MET, MMP2, PIM1, PTPN1, SLC6A2, SLC6A4, SRC, TERT 1.84205
[CC] GO:0043227 membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, AR, AURKB, AXL, CA1, CA2, CA4, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GPER1, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SHBG, SRC, TERT, TYR, XDH 1.70631
[CC] GO:0005783 None ADORA1, CA4, CES1, CES2, CYP19A1, FLT3, GPER1, KDR, PTPN1, XDH 1.57101
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, AR, AURKB, CA1, CA2, CA4, CA7, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GPER1, HSD17B1, HSD17B2, KCNH2, KDR, MMP2, MMP9, PIM1, PTPN1, SLC6A4, SRC, TERT, TYR, XDH 1.50365
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, AR, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, TYR, XDH 14.2642
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PPARA, RORC 8.11324
[MF] GO:0004879 nuclear receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PPARA, RORC 8.11324
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AOX1, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, SRC, TERT, TYR, XDH 8.04772
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7 8.04772
[MF] GO:0005496 steroid binding AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, HSD17B1, RORC, SHBG 7.97811
[MF] GO:0003707 steroid hormone receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PPARA, RORC 7.73239
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTPN1, SRC, TERT, TYR, XDH 7.25118
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA7, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC 6.86937
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, TERT, TYR, XDH 6.18201
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, TERT, TYR, XDH 5.81195
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7 5.09016
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, XDH 4.91605
[MF] GO:0008289 lipid binding AR, AXL, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPER1, HSD17B1, PPARA, RORC, SHBG 4.5498
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7 4.46441
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, ADRA2A, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SLC6A4, SRC 4.36202
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, HSD17B1, HSD17B2, TYR, XDH 4.26572
[MF] GO:0042562 hormone binding ACHE, AR, GPER1, HSD17B1, IGF1R, SHBG 4.20321
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19 4.16188
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2, GPER1 4.10963
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA2A, AR, AXL, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, IGF1R, KCNH2, KDR, MET, PPARA, RORC 4.08637
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, TYR 3.95372
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ADRA2A, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SRC 3.92407
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.78619
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.59938
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.57495
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA2A, AR, AXL, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, IGF1R, KCNH2, KDR, MET, PPARA, RORC 3.46045
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, SRC 3.33265
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA2A, AR, AXL, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, IGF1R, KCNH2, KDR, MET, PPARA, RORC 3.31685
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD17B1, HSD17B2, XDH 3.20973
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, SRC 3.18122
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.14297
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA2A, AR, AXL, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, IGF1R, KCNH2, KDR, MET, PPARA, RORC 3.00005
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FLT3, IGF1R, KDR, MET, PIM1, PPARA, SLC6A4, SRC 2.95716
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, TYR 2.95097
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.83359
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.83359
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, HSD17B1, SRC, XDH 2.74818
[MF] GO:0042802 identical protein binding ACHE, ADRA2A, AOX1, CSNK2A1, ESR1, ESR2, FLT3, IGF1R, KCNH2, KDR, MET, MMP9, SLC6A4, TERT, TYR, XDH 2.68976
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.63221
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.6097
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7 2.6097
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIM1, SRC 2.56341
[MF] GO:0005330 None SLC6A2, SLC6A4 2.46301
[MF] GO:0047374 None CES1, CES2 2.46301
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.44873
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.25214
[MF] GO:0032795 None ADORA1, ADRA2A 2.25214
[MF] GO:0005497 None AR, SHBG 2.25214
[MF] GO:0052689 carboxylic ester hydrolase activity ACHE, CA1, CA2, CES1, CES2 2.17992
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIM1, SRC 2.04863
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.00025


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.2563
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA14 9.2384
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.24
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, GPER1, MMP9, ESR1, ESR2 4.9618
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, TYR, CYP2C19, CYP19A1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, CES1 4.515
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 4.474
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.4387
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 4.1418
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.1418
Pathways in cancer_Homo sapiens_hsa05200 AR, FLT3, MMP1, MMP2, MMP9, MET, IGF1R 2.9333
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.2821
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP1A2, CYP1A1, CYP1B1, CYP2C19 3.0671
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH, CES2, CES1 2.5931
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.1133
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET, CDC25B 2.0187
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.1807
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1, CYP2C19 2.1332
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP1A2, CYP1A1, CYP1B1 2.1133
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, IGF1R 1.8548
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.9952
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, IGF1R 1.823
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5, CYP2C19, SLC6A4 1.7595
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.6068
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1, ADRA2A 1.3732
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.3764
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3755
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.1347
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.3581
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.3049
Prostate cancer_Homo sapiens_hsa05215 AR, IGF1R 1.1347
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3732
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1 1.0674
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.2912
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.1313
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.0818
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.3043
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.0215
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, CYP2C19 1.3569
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, ADORA1, ADRA2A 0.9983
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 1.0215
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2251
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.9983
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 KDR, MET, IGF1R 0.8441
Oocyte meiosis_Homo sapiens_hsa04114 AR, IGF1R 0.9821
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8116
Hepatitis B_Homo sapiens_hsa05161 SRC, MMP9 0.8742
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9983
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.9935
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.8874
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP2C19 1.823
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.7286
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8959
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, AOX1 0.8441
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9658
cAMP signaling pathway_Homo sapiens_hsa04024 ADORA1, PPARA 0.7022
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7731
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7199
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2812
HTLV-I infection_Homo sapiens_hsa05166 TERT 0.2812
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1 0.3416
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.5061
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.3309
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3715
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3407
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3629
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3715
Platelet activation_Homo sapiens_hsa04611 SRC 0.4564
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4793
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.4157
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.4041
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3629
Measles_Homo sapiens_hsa05162 CSNK2A1 0.4402
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5061
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.4793
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.4439
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4332
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.4564
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5025
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.4366
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5056
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5007
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5061
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.4439
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.498
Gap junction_Homo sapiens_hsa04540 SRC 0.5061
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5007
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5061
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.4613
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.4564
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5061
Axon guidance_Homo sapiens_hsa04360 MET 0.4521
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5061
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.5056
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5056
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5056
Peroxisome_Homo sapiens_hsa04146 XDH 0.5061
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5435
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5717
Glioma_Homo sapiens_hsa05214 IGF1R 0.5717
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5541
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5732
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5717
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5715
Bile secretion_Homo sapiens_hsa04976 CA2 0.5541
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.5717
Shigellosis_Homo sapiens_hsa05131 SRC 0.5717
Malaria_Homo sapiens_hsa05144 MET 0.6482
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6521
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6501
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8099
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8239
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8441
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8167
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8441
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.0736
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0215
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2929


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)