TCM Prescription: Ba Zheng Powder



Prescription Description
Prescription IDTCMF7309
Pinyin NameBa Zheng San
Chinese Name八正散
English NameBa Zheng Powder
Function Description膀胱结热, 小便涩痛
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with IndicationBladder
ReferenceTaiwan Herbal Pharmacopeia 2nd Edition English Version
Reference Book/linkhttps://www.mohw.gov.tw/cp-3690-39025-2.html
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH241 Plantago asiatica 车前子 TCMH241 ITSAB3641-14
TCMH1706 Dianthus superbus 瞿麦 TCMH1706 ITSAJ4556-14
TCMH933 Talcum 滑石 TCMH933
TCMH363 Rheum officinale 大黄 TCMH363 ITSAJ4685-14
TCMH2641 Gardenia jasminoides 栀子 TCMH2641 ITSAJ4473-14
TCMH177 Polygonum aviculare 萹蓄 TCMH177 ITSAG3700-14
TCMH1531 Akebia quinata 木通 TCMH1531 ITSAJ4440-14
TCMH637 Radix glycyrrhizae uralensis 甘草梢 TCMH637
TCMH438 Juncus effusus 灯心草 TCMH438 ITSAD4376-14
Reference: Taiwan Herbal Pharmacopeia 2nd Edition English Version

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT151 PRKCA Protein kinase C alpha Kinase P17252
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT214 MGLL Monoglyceride lipase Unclassified Q99685
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT22 ALPI Intestinal alkaline phosphatase Hydrolase P09923
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT304 MMP14 Matrix metalloproteinase 14 Hydrolase P50281
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT334 EBP 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase Isomerase Q15125
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT434 JAK2 Tyrosine-protein kinase JAK2 Kinase O60674
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT567 DNMT1 DNA (cytosine-5)-methyltransferase 1 Transferase P26358
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT645 HTR1E Serotonin 1e (5-HT1e) receptor GPCR P28566
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT815 HTR1D Serotonin 1d (5-HT1d) receptor GPCR P28221
TCMT816 HTR1B Serotonin 1b (5-HT1b) receptor GPCR P28222
TCMT817 HTR4 Serotonin 4 (5-HT4) receptor GPCR Q13639
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT881 BBOX1 Gamma-butyrobetaine dioxygenase Oxidoreductase O75936


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1182 Streptococcus sanguinis
TCMT1183 Candida albicans SC5314
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1198 Serratia marcescens
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1208 Escherichia coli K12
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0007210 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.5366
[BP] GO:0098664 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.5366
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CNR1, CNR2, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IGF1R, JAK2, KCNH2, KDR, KIT, MMP2, MMP9, PIK3CA, PRKCA, PTGS2, RORC, SRC, TERT, TYR 13.8377
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FABP4, FLT3, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR4, HTR7, JAK2, KCNH2, KDR, KIT, MET, PIK3CA, PIK3CB, PRKCA, PTGS1, PTGS2, SRC, TERT, XDH 11.6691
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CNR1, CNR2, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR1B, HTR5A, IGF1R, JAK2, KDR, KIT, MMP2, PIK3CA, PRKCA, PTGS2, RORC, SRC, TYR 10.3006
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CA9, CNR1, CNR2, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, FABP3, HSD11B2, HSD17B2, HTR1B, HTR5A, IGF1R, JAK2, MMP2, MMP9, PIK3CA, PTGS2, RORC, SRC, TYR 10.3006
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CNR1, CNR2, CYP1A1, CYP1A2, ESR1, FABP3, FLT3, HSD11B2, HSD17B2, HTR1B, HTR5A, JAK2, PTGS2, RORC, SRC, TYR 9.20842
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPI, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EBP, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD11B2, HSD17B2, KIT, MET, MGLL, PIK3CA, PIK3CB, PTGS1, PTGS2 9.20842
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA3, AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CNR1, CNR2, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IGF1R, JAK2, KCNH2, KDR, KIT, MGLL, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A, TYR 9.10634
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, KIT, MMP9, PTGS2, SRC, TERT 8.51571
[BP] GO:0042493 response to drug ABCB1, AKR1B1, APEX1, AXL, BCL2, CA9, CNR1, CNR2, CYP1A1, CYP1B1, FABP3, HSD11B2, HTR1B, HTR2A, HTR2B, HTR2C, KCNH2, KDR, PTGS2, SRC 8.14747
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, ALOX15, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CNR1, CNR2, CYP19A1, CYP1B1, DYRK1A, ESR1, ESR2, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, JAK2, KDR, KIT, MET, MGLL, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TERT, XDH 8.05864
[BP] GO:0042127 regulation of cell proliferation ADORA3, AKR1B1, APP, BCL2, CDC25B, CYP1B1, DNMT1, ESR1, FABP3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, JAK2, KDR, KIT, MMP12, MMP2, MMP9, PIM1, PRKCA, PTGS1, PTGS2, SRC, TERT, XDH 7.92538
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, ALOX15, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CNR1, CNR2, CYP19A1, CYP1B1, DYRK1A, ESR1, ESR2, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, JAK2, KDR, KIT, MET, MGLL, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TERT, XDH 7.92133
[BP] GO:0043067 regulation of programmed cell death AKR1B1, APEX1, AURKB, AXL, BCL2, CNR1, CYP1B1, ESR1, FLT3, GLO1, HTR2B, IGF1R, JAK2, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS2, PTPN1, SRC, TERT, TOP2A, XDH 7.89576
[BP] GO:0010647 positive regulation of cell communication AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CYP19A1, CYP1B1, FLT3, HTR2A, HTR2B, HTR2C, HTR6, JAK2, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TERT, XDH 7.89576
[BP] GO:0023056 positive regulation of signaling AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CYP19A1, CYP1B1, FLT3, HTR2A, HTR2B, HTR2C, HTR6, JAK2, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TERT, XDH 7.86633
[BP] GO:0032501 multicellular organismal process AKR1B1, AKR1B10, ALOX15, ALOX5, ALPI, ALPL, APP, AXL, BCL2, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, ESR1, FABP4, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR7, IGF1R, JAK2, KCNH2, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PTGS2, RORC, SRC, TYR 7.82457
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, ALOX15, APP, AXL, BCL2, CYP1B1, FLT3, HTR2A, HTR2B, HTR2C, HTR6, JAK2, KDR, KIT, MET, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, XDH 7.80058
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CNR1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, FABP3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, JAK2, KCNH2, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A, XDH 7.69782
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EBP, FABP3, FUT7, GLO1, HTR2B, HTR2C, MGLL, PIK3CA, PIM1, PTGS1, PTGS2, TYR, XDH 7.55408
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, APP, BCL2, CA2, CA9, CNR1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, HSD11B2, HTR1B, HTR5A, PTGS2, RORC, SRC, TYR 7.47358
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, FABP4, FLT3, HTR1B, IGF1R, KCNH2, KDR, KIT, MMP2, MMP9, PIK3CA, PTGS2, RORC, SRC, TERT 7.43622
[BP] GO:0010941 regulation of cell death AKR1B1, APEX1, AURKB, AXL, BCL2, CNR1, CYP1B1, ESR1, FLT3, GLO1, HTR2B, IGF1R, JAK2, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS2, PTPN1, SRC, TERT, TOP2A, XDH 7.2828
[BP] GO:0097756 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 7.00923
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, ESR1, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, JAK2, KDR, KIT, MMP12, MMP2, MMP9, PIM1, PRKCA, PTGS2, TERT 6.93936
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CNR1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, FABP3, FABP4, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, JAK2, KCNH2, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A, XDH 6.93936
[BP] GO:0007198 None HTR1A, HTR1B, HTR5A, HTR7 6.91457
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EBP, ESR1, HSD11B1, HSD11B2, HSD17B2 6.85173
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, SRC 6.77104
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPI, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, EBP, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, JAK2, KCNH2, KDR, KIT, MET, MGLL, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A, TYR, XDH 6.75495
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.71456
[BP] GO:0042981 regulation of apoptotic process AKR1B1, APEX1, AURKB, AXL, BCL2, CNR1, CYP1B1, ESR1, FLT3, GLO1, HTR2B, IGF1R, JAK2, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS2, PTPN1, SRC, TERT, TOP2A, XDH 6.67131
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, ALOX15, APP, AXL, BCL2, CYP1B1, FLT3, HTR2A, HTR2B, HTR2C, HTR6, JAK2, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TERT, XDH 6.62559
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, HTR1B, HTR1D, JAK2, KDR, SRC 6.55902
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CNR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, EBP, ESR1, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B2, HTR2A, HTR2B, HTR5A, JAK2, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS2, RORC, SRC, TERT, TOP2A, TYR 6.49459
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CYP1B1, DYRK1A, ESR1, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, JAK2, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, XDH 6.43768
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPI, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, DYRK1A, FLT3, HTR2B, HTR2C, IGF1R, JAK2, KCNH2, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS2, PTPN1, SRC, XDH 6.42744
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AURKB, AXL, BCL2, GLO1, HTR2B, IGF1R, JAK2, KDR, KIT, MET, MMP9, PIK3CA, PIM1, PRKCA, PTGS2, PTPN1, SRC, TERT 6.3631
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.32193
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, APP, BCL2, CA2, CA9, CYP1A2, DNMT1, ESR1, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, IGF1R, KIT, MMP2, PTGS2, SRC 6.30636
[BP] GO:0042310 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7 6.27417
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CYP1A1, CYP1B1, DNMT1, ESR1, FABP4, FLT3, HTR1B, IGF1R, KDR, KIT, MMP2, PIK3CA, PTGS2, RORC, SRC 6.27417
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR2A, HTR2C, JAK2, PRKCA 6.27417
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, MGLL, PTGS1, PTGS2 6.18227
[BP] GO:0042592 homeostatic process AKR1B1, APEX1, APP, AXL, BCL2, CA12, CA2, CA7, CNR1, ESR1, FABP3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, JAK2, KCNH2, MET, PIK3CA, PIK3CB, SRC, TERT 6.15814
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, FABP4, FLT3, HTR1B, IGF1R, JAK2, KCNH2, KDR, KIT, MMP2, MMP9, PIK3CA, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A 6.15814
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA3, ALOX15, APEX1, APP, AXL, BCL2, CA2, CA7, CNR1, CYP19A1, CYP1B1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, JAK2, KCNH2, KDR, KIT, MET, MMP12, MMP9, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TERT 6.15814
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPI, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, DYRK1A, FLT3, HTR2B, HTR2C, IGF1R, JAK2, KCNH2, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS2, PTPN1, SRC, XDH 6.06968
[BP] GO:0007187 None CNR1, CNR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR4, HTR5A, HTR6, HTR7 6.02103
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, ALPI, CYP19A1, CYP1A1, EBP, HSD11B1, HSD11B2, HSD17B2, MGLL, PIK3CA, PIK3CB, PTGS1, PTGS2 5.86447
[BP] GO:0001934 positive regulation of protein phosphorylation ALOX15, APP, BCL2, CDC25B, FLT3, HTR2A, HTR2B, HTR2C, JAK2, KDR, KIT, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, XDH 5.86447
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, MGLL, PTGS1, PTGS2 5.83825
[BP] GO:0060548 negative regulation of cell death AKR1B1, AURKB, AXL, BCL2, GLO1, HTR2B, IGF1R, JAK2, KDR, KIT, MET, MMP9, PIK3CA, PIM1, PRKCA, PTGS2, PTPN1, SRC, TERT 5.83825
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.77083
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CYP1A2, ESR1, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, KIT, PTGS2, SRC 5.73649
[BP] GO:0031401 positive regulation of protein modification process ALOX15, APP, BCL2, CDC25B, DNMT1, DYRK1A, FLT3, HTR2A, HTR2B, HTR2C, JAK2, KDR, KIT, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, XDH 5.66928
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPI, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B2, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, JAK2, KCNH2, KDR, KIT, MET, MGLL, MMP1, MMP2, NQO2, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A, TYR, XDH 5.66319
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CNR1, CNR2, CYP19A1, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, FABP3, FABP4, GLO1, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, JAK2, KCNH2, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIM1, PRKCA, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A, XDH 5.63699
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, MGLL, PTGS1, PTGS2 5.63699
[BP] GO:0010562 positive regulation of phosphorus metabolic process ALOX15, APP, BCL2, CDC25B, FABP3, FLT3, HTR2A, HTR2B, HTR2C, JAK2, KDR, KIT, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, XDH 5.62415
[BP] GO:0045937 positive regulation of phosphate metabolic process ALOX15, APP, BCL2, CDC25B, FABP3, FLT3, HTR2A, HTR2B, HTR2C, JAK2, KDR, KIT, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, XDH 5.62415
[BP] GO:0042327 positive regulation of phosphorylation ALOX15, APP, BCL2, CDC25B, FLT3, HTR2A, HTR2B, HTR2C, JAK2, KDR, KIT, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, XDH 5.61882
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, ALOX15, APP, AXL, BCL2, CNR1, CYP1B1, FABP4, FLT3, HTR2A, HTR2B, HTR2C, HTR6, JAK2, KDR, KIT, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TERT, XDH 5.60718
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, JAK2, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTPN1, SRC 5.58588
[BP] GO:0043410 positive regulation of MAPK cascade ALOX15, APP, FLT3, HTR2A, HTR2B, HTR2C, JAK2, KDR, KIT, PIK3CB, PRKCA, PTPN1, SRC, XDH 5.46229
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, SRC 5.44813
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HTR1B, JAK2, MMP2, MMP9, PTGS2, TERT 5.29114
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation HTR1B, JAK2, MMP2, MMP9, TERT 5.29048
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA3, APP, CA2, CNR1, CNR2, ESR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, JAK2, PIK3CA, PIK3CB, SRC 5.26515
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, DYRK1A, FLT3, HTR2B, IGF1R, JAK2, KCNH2, KDR, KIT, MET, PIK3CA, PIM1, PRKCA, SRC 5.25161
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, CNR1, ESR1, FABP3, FABP4, HTR2A, HTR2B, HTR2C, JAK2, KCNH2, MET, PIK3CA, PIK3CB 5.20375
[BP] GO:0071073 None FABP3, HTR2A, HTR2B, HTR2C 5.1986
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, APP, BACE1, CA2, CA7, CNR1, CNR2, HTR1B, HTR2A, KIT, PTGS2 5.16317
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, APP, BACE1, CA2, CA7, CNR1, CNR2, HTR1B, HTR2A, KIT, PTGS2 5.16317
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, PTGS2, SRC 5.15504
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ALOX15, APP, AXL, BCL2, CA2, CA7, CNR1, CYP19A1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, JAK2, KCNH2, MMP12, MMP9, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TERT 5.13675
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, ALPI, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, KIT, MET, MGLL, PIK3CA, PIK3CB, PTGS1, PTGS2 5.08987
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AURKB, AXL, BCL2, GLO1, HTR2B, IGF1R, JAK2, KDR, MMP9, PIK3CA, PIM1, PRKCA, PTGS2, PTPN1, SRC, TERT 5.08492
[BP] GO:0019220 regulation of phosphate metabolic process ALOX15, APP, BCL2, CDC25B, FABP3, FABP4, FLT3, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, JAK2, KDR, KIT, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, XDH 5.04664
[BP] GO:0051174 regulation of phosphorus metabolic process ALOX15, APP, BCL2, CDC25B, FABP3, FABP4, FLT3, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, JAK2, KDR, KIT, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, XDH 4.9918
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B2 4.96956
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, DYRK1A, FLT3, IGF1R, JAK2, KDR, KIT, MET, SRC 4.95433
[BP] GO:0010038 response to metal ion ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, FABP4, KIT, MMP9, PTGS2, TERT 4.95433
[BP] GO:0048583 regulation of response to stimulus ABCB1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CNR1, CNR2, CYP19A1, CYP1B1, DYRK1A, ESR1, ESR2, FABP4, FLT3, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, JAK2, KDR, KIT, MET, MGLL, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TERT, XDH 4.95433
[BP] GO:0030334 regulation of cell migration ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, IGF1R, JAK2, KDR, KIT, MET, MMP9, PRKCA, PTGS2, SRC, TERT 4.94039
[BP] GO:0018212 peptidyl-tyrosine modification AXL, DYRK1A, FLT3, IGF1R, JAK2, KDR, KIT, MET, SRC 4.90789
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA3, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CNR1, CNR2, CYP19A1, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, FABP3, FABP4, GLO1, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, JAK2, KCNH2, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIM1, PRKCA, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A, XDH 4.8928
[BP] GO:0040012 regulation of locomotion ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, HTR1D, IGF1R, JAK2, KDR, KIT, MET, MMP9, PRKCA, PTGS2, SRC, TERT 4.87472
[BP] GO:0001932 regulation of protein phosphorylation ALOX15, APP, BCL2, CDC25B, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, JAK2, KDR, KIT, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, XDH 4.85392
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 4.85023
[BP] GO:0046777 protein autophosphorylation AURKB, DYRK1A, FLT3, IGF1R, JAK2, KDR, KIT, PIM1, SRC 4.79674
[BP] GO:0032270 positive regulation of cellular protein metabolic process ALOX15, APP, BCL2, CDC25B, DNMT1, DYRK1A, ESR1, FLT3, HTR2A, HTR2B, HTR2C, JAK2, KDR, KIT, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, XDH 4.77043
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, DYRK1A, FLT3, HTR2B, IGF1R, JAK2, KCNH2, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, PRKCA, SRC 4.72025
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, BCL2, CYP1B1, JAK2, MMP9, PTGS1, PTGS2, SRC 4.67897
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 4.61695
[BP] GO:2000145 regulation of cell motility ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, IGF1R, JAK2, KDR, KIT, MET, MMP9, PRKCA, PTGS2, SRC, TERT 4.60612
[BP] GO:0043408 regulation of MAPK cascade ALOX15, APP, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, JAK2, KDR, KIT, PIK3CB, PRKCA, PTPN1, SRC, XDH 4.60032
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, MGLL, PTGS1, PTGS2 4.59798
[BP] GO:0032228 regulation of synaptic transmission, GABAergic CA2, CA7, CNR1, CNR2, HTR1B 4.5574
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, IGF1R, JAK2, KDR, KIT, MET, MMP9, PRKCA, PTGS2, SRC, TERT 4.51099
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, MGLL, PTGS1, PTGS2 4.49112
[BP] GO:0003018 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SRC 4.49112
[BP] GO:0050795 None CNR1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B 4.47001
[BP] GO:0007165 signal transduction ADORA3, AKR1B1, APP, AXL, BCL2, CA1, CA2, CNR1, CNR2, CYP1B1, DNMT1, EBP, ESR1, ESR2, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, JAK2, KCNH2, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PTPN1, RORC, SRC 4.47001
[BP] GO:0019216 regulation of lipid metabolic process CNR1, CYP1A1, FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, PTGS2, RORC, SRC 4.47001
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.4209
[BP] GO:0051247 positive regulation of protein metabolic process ALOX15, APP, BCL2, CDC25B, DNMT1, DYRK1A, ESR1, FLT3, HTR2A, HTR2B, HTR2C, JAK2, KDR, KIT, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, XDH 4.39848
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, IGF1R, JAK2, KDR, KIT, MET, MMP9, PRKCA, PTGS2, SRC, TERT 4.36989
[BP] GO:0031399 regulation of protein modification process ALOX15, APP, BCL2, CDC25B, DNMT1, DYRK1A, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, JAK2, KDR, KIT, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, XDH 4.36602
[BP] GO:0031325 positive regulation of cellular metabolic process ALOX15, APP, AURKB, BCL2, CDC25B, DNMT1, DYRK1A, ESR1, ESR2, FABP3, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, JAK2, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A, XDH 4.3654
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, BCL2, CYP1A1, ESR1, FLT3, HTR1A, KIT, MET, PIK3CB, PIM1, SRC, TYR 4.33717
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, CNR1, CNR2, DNMT1, FABP3, FLT3, HSD11B2, HTR1B, IGF1R, MMP2, PTGS2, SRC, TYR 4.32852
[BP] GO:0042325 regulation of phosphorylation ALOX15, APP, BCL2, CDC25B, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, JAK2, KDR, KIT, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, XDH 4.30663
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, IGF1R, JAK2, KDR, KIT, MET, MMP9, PRKCA, PTGS2, SRC, TERT 4.26054
[BP] GO:0009966 regulation of signal transduction AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CYP1B1, DYRK1A, ESR1, ESR2, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, JAK2, KDR, KIT, MET, MGLL, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TERT, XDH 4.24765
[BP] GO:0065007 biological regulation ABCB1, ACHE, ADORA3, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, EBP, ESR1, ESR2, FABP3, FABP4, FLT3, GLO1, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, JAK2, KCNH2, KDR, KIT, MET, MGLL, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A, XDH 4.22989
[BP] GO:0032844 regulation of homeostatic process AURKB, BCL2, CA2, CA7, CNR1, HTR2A, HTR2B, HTR2C, KDR, PIK3CB, PTGS2, SRC 4.22989
[BP] GO:0071071 None FABP3, HTR2A, HTR2B, HTR2C 4.22569
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, JAK2, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTPN1, SRC 4.20344
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ALOX15, APP, AURKB, BCL2, CDC25B, DNMT1, DYRK1A, ESR1, ESR2, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, JAK2, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A, XDH 4.20344
[BP] GO:0051270 regulation of cellular component movement ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, IGF1R, JAK2, KDR, KIT, MET, MMP9, PRKCA, PTGS2, SRC, TERT 4.20344
[BP] GO:1904705 regulation of vascular smooth muscle cell proliferation HTR1B, JAK2, MMP2, MMP9, TERT 4.18621
[BP] GO:0006950 response to stress ACHE, ADORA3, AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, HSD11B2, HTR1A, HTR2C, JAK2, KIT, MGLL, MMP2, MMP9, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, SRC, TERT, TOP2A 4.12826
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, IGF1R, JAK2, KDR, KIT, MET, MMP9, PRKCA, PTGS2, SRC, TERT 4.12719
[BP] GO:0007193 None HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 4.08785
[BP] GO:0010513 None HTR2A, HTR2B, HTR2C 4.08558
[BP] GO:0097746 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 4.05356
[BP] GO:0035296 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 4.05356
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, EBP, HTR1A, TYR 3.97955
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, HTR1B, JAK2, MMP2, MMP9, PTGS2, TERT 3.9679
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, CNR1, CNR2, DNMT1, FABP3, FLT3, HSD11B2, HTR1B, IGF1R, MMP2, PTGS2, SRC, TYR 3.96198
[BP] GO:0080134 regulation of response to stress ABCB1, APP, CNR1, CNR2, CYP19A1, DYRK1A, ESR1, FABP4, IGF1R, JAK2, MET, MGLL, MMP12, MMP2, PRKCA, PTGS2, PTPN1, SRC, TERT, XDH 3.91065
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPI, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, EBP, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, JAK2, KCNH2, KDR, KIT, MET, MGLL, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A, TYR, XDH 3.90438
[BP] GO:0050880 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 3.88769
[BP] GO:0016477 cell migration AXL, CNR2, CYP1B1, FUT7, HTR2B, HTR6, JAK2, KDR, KIT, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC 3.88026
[BP] GO:0035150 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 3.87052
[BP] GO:0010604 positive regulation of macromolecule metabolic process ALOX15, APP, AURKB, BCL2, CDC25B, DNMT1, DYRK1A, ESR1, ESR2, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, JAK2, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A, XDH 3.84701
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, APP, HTR2A, HTR2B, HTR2C, KDR, PRKCA, SRC 3.80819
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, APP, CYP1A1, CYP1B1, ESR1, FLT3, PTGS2, RORC, SRC 3.76009
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, HTR2A, HTR2B, HTR2C, KDR, PRKCA, PTPN1, SRC 3.72766
[BP] GO:0043271 negative regulation of ion transport BCL2, CNR1, HTR1B, HTR2A, KCNH2, MMP9, PTGS2 3.71687
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AXL, CYP1B1, DNMT1, ESR1, IGF1R, MMP2, MMP9, PIK3CA, PTGS2, RORC, SRC 3.69798
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, JAK2, PTGS2, SRC 3.69798
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPI, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, EBP, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD11B2, HSD17B2, HTR2B, HTR2C, IGF1R, JAK2, KCNH2, KDR, KIT, MET, MGLL, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A, TYR, XDH 3.69798
[BP] GO:0003013 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SRC 3.69743
[BP] GO:0003008 None AKR1B1, APP, BCL2, CNR1, CNR2, CYP1B1, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, KCNH2, KIT, PIK3CA, PTGS2, SRC, TYR 3.66098
[BP] GO:2000021 regulation of ion homeostasis BCL2, CA2, CA7, HTR2A, HTR2B, HTR2C, KDR, SRC 3.65486
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, HTR1B, KCNH2, KDR, PTGS2, SRC 3.64323
[BP] GO:0009628 response to abiotic stimulus AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, HSD11B2, HTR1B, HTR2A, HTR2B, KIT, MMP2, PTGS2, SRC, TERT, TYR 3.62697
[BP] GO:0009893 positive regulation of metabolic process ALOX15, APP, AURKB, BCL2, CDC25B, DNMT1, DYRK1A, ESR1, ESR2, FABP3, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, JAK2, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A, XDH 3.62697
[BP] GO:0048511 rhythmic process AXL, BCL2, DYRK1A, ESR1, HTR7, KIT, RORC, SRC, TOP2A 3.62697
[BP] GO:0010511 None HTR2A, HTR2B, HTR2C 3.61579
[BP] GO:0050801 ion homeostasis APP, BCL2, CA12, CA2, CA7, ESR1, FABP3, HTR2A, HTR2B, HTR2C, JAK2, KCNH2, PIK3CB 3.54719
[BP] GO:0040011 locomotion AXL, CNR2, CYP1B1, FUT7, HTR2B, HTR6, JAK2, KDR, KIT, MET, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC 3.52029
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, FLT3, HSD11B2, HTR1B, PTGS2, SRC 3.5104
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, MGLL, PTGS1, PTGS2 3.49502
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, JAK2, PTGS2, SRC 3.49502
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, FLT3, HSD11B2, HTR1B, PTGS2, SRC 3.48721
[BP] GO:0007188 None CNR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 3.47078
[BP] GO:0099536 None CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 3.46984
[BP] GO:0099537 None CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 3.46984
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CNR1, CNR2, CYP1B1, ESR1, FABP4, IGF1R, JAK2, MET, MMP9, PIM1, PRKCA, PTGS2, PTPN1, SRC 3.46487
[BP] GO:0048870 cell motility AXL, CNR2, CYP1B1, FUT7, HTR2B, HTR6, JAK2, KDR, KIT, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC 3.44949
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CYP19A1, CYP1A1, CYP1A2, EBP, ESR1, FLT3, HSD11B1, HSD17B2, KDR, KIT, PIK3CA, SRC, TYR 3.37629
[BP] GO:0007568 aging APEX1, AURKB, BCL2, CNR1, CYP1A1, HTR2A, PTGS2, TERT 3.36818
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B2 3.32635
[BP] GO:0048015 phosphatidylinositol-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 3.32635
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC 3.31241
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B2 3.31241
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 3.31241
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, ALPI, FABP3, FABP4, KIT, MET, MGLL, PIK3CA, PIK3CB 3.30054
[BP] GO:0050794 regulation of cellular process ACHE, ADORA3, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA7, CA9, CDC25B, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, EBP, ESR1, ESR2, FABP3, FABP4, FLT3, GLO1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, JAK2, KCNH2, KDR, KIT, MET, MGLL, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A, XDH 3.27531
[BP] GO:0043269 regulation of ion transport ABCB1, APP, BCL2, CA2, CA7, CNR1, HTR1A, HTR1B, HTR2A, KCNH2, MMP9, PTGS2 3.2603
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, BCL2, CDC25B, CNR1, CYP19A1, CYP1A1, ESR1, HSD11B2, HSD17B2, KIT, MMP2, MMP9, PTGS2, SRC, TOP2A 3.24226
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, CNR2, HTR1B, HTR2A, PTGS2 3.24226
[BP] GO:0046889 None FABP3, HTR2A, HTR2B, HTR2C, PTGS2 3.24226
[BP] GO:0048017 inositol lipid-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 3.24226
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, MMP9, SRC 3.20373
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, NQO2, PTGS1, RORC 3.19587
[BP] GO:0050789 regulation of biological process ABCB1, ACHE, ADORA3, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA7, CA9, CDC25B, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, EBP, ESR1, ESR2, FABP3, FABP4, FLT3, GLO1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, JAK2, KCNH2, KDR, KIT, MET, MGLL, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A, XDH 3.15782
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.15782
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.15782
[BP] GO:0050790 regulation of catalytic activity ADORA3, APP, AURKB, BCL2, CDC25B, CNR1, CNR2, ESR1, FABP4, FLT3, HTR2A, HTR2B, IGF1R, JAK2, KIT, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TERT, XDH 3.15782
[BP] GO:0006928 movement of cell or subcellular component APP, AXL, CNR2, CYP1B1, FUT7, HTR2B, HTR6, JAK2, KDR, KIT, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, SRC 3.14412
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, BCL2, CYP1B1, DNMT1, HTR2A, HTR2B, HTR5A, IGF1R, JAK2, KCNH2, KDR, KIT, MET, PIK3CA, PIK3CB, PRKCA, PTPN1, SRC 3.14369
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA3, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPI, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, EBP, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, JAK2, KCNH2, KDR, KIT, MET, MGLL, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A, TYR, XDH 3.12933
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AXL, BCL2, CA2, CNR1, CYP1B1, HTR2A, HTR2B, JAK2, KDR, KIT, MET, MMP12, MMP9, PIM1, PRKCA, PTGS2, SRC, TERT 3.11889
[BP] GO:0043405 regulation of MAP kinase activity FLT3, HTR2A, HTR2B, IGF1R, JAK2, KIT, PIK3CB, PTPN1, SRC 3.08087
[BP] GO:0010863 positive regulation of phospholipase C activity ESR1, HTR2A, HTR2B, KIT 3.08059
[BP] GO:0006952 defense response ADORA3, ALOX15, APP, AXL, BCL2, CNR2, HTR1A, HTR2C, JAK2, KIT, MGLL, PIK3CA, PIK3CB, PTGS1, PTGS2, SRC 3.06295
[BP] GO:0006954 inflammatory response ADORA3, ALOX15, AXL, CNR2, KIT, MGLL, PIK3CA, PIK3CB, PTGS1, PTGS2 3.06295
[BP] GO:0098771 inorganic ion homeostasis APP, BCL2, CA12, CA2, CA7, ESR1, HTR2A, HTR2B, HTR2C, JAK2, KCNH2, PIK3CB 3.06295
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 3.04391
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, GLO1, KIT, MMP9, RORC 3.04011
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 3.02796
[BP] GO:0043406 positive regulation of MAP kinase activity FLT3, HTR2A, HTR2B, JAK2, KIT, PIK3CB, PTPN1, SRC 3.00885
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, EBP, ESR1, FLT3, HSD11B1, HSD17B2, HTR5A, JAK2, KDR, KIT, MMP9, PIK3CA, PIM1, PTGS2, RORC, SRC, TYR 3.00885
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, PTGS2, SRC 3.00384
[BP] GO:0010648 negative regulation of cell communication ACHE, BCL2, CNR2, DYRK1A, ESR1, ESR2, HTR1B, HTR2A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TERT, XDH 2.99688
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, EBP, HSD11B1, HSD11B2, HSD17B2 2.98748
[BP] GO:0023057 negative regulation of signaling ACHE, BCL2, CNR2, DYRK1A, ESR1, ESR2, HTR1B, HTR2A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TERT, XDH 2.98271
[BP] GO:1900274 regulation of phospholipase C activity ESR1, HTR2A, HTR2B, KIT 2.95011
[BP] GO:0044093 positive regulation of molecular function ABCB1, APP, AURKB, BCL2, CDC25B, ESR1, ESR2, FLT3, HTR2A, HTR2B, JAK2, KIT, MET, MMP9, PIK3CA, PIK3CB, PTPN1, SRC, TERT, XDH 2.91636
[BP] GO:0046456 icosanoid biosynthetic process ALOX15, ALOX5, PTGS1, PTGS2 2.90515
[BP] GO:0046427 positive regulation of JAK-STAT cascade AKR1B1, CYP1B1, FLT3, JAK2, KIT 2.90208
[BP] GO:0045859 regulation of protein kinase activity APP, CDC25B, FABP4, FLT3, HTR2A, HTR2B, IGF1R, JAK2, KIT, PIK3CA, PIK3CB, PTPN1, SRC 2.88457
[BP] GO:0007208 None HTR2A, HTR2C 2.87687
[BP] GO:1904894 positive regulation of STAT cascade AKR1B1, CYP1B1, FLT3, JAK2, KIT 2.85927
[BP] GO:1903530 regulation of secretion by cell ACHE, CNR1, CYP19A1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, JAK2, MMP12, PRKCA, SRC 2.83735
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, APP, DNMT1, ESR1, FLT3, HTR1B, IGF1R, KIT, MMP2, PTGS2, SRC 2.83269
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPI, ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CYP1A1, CYP1A2, DYRK1A, ESR1, FLT3, FUT7, GLO1, HTR1A, HTR2B, HTR2C, IGF1R, JAK2, KCNH2, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PRKCA, PTGS2, PTPN1, SRC, TOP2A, TYR, XDH 2.82863
[BP] GO:0009892 negative regulation of metabolic process APEX1, APP, AURKB, BCL2, CNR1, CNR2, DNMT1, DYRK1A, ESR1, ESR2, FABP4, HTR1B, HTR1E, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PRKCA, PTGS2, PTPN1, RORC, SRC, TERT, XDH 2.81449
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, SRC, TERT 2.81363
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA3, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CNR1, CNR2, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, FABP3, FABP4, FLT3, GLO1, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, JAK2, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A, XDH 2.76828
[BP] GO:0032787 None ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, MGLL, PTGS1, PTGS2 2.7509
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.7509
[BP] GO:1901989 None APEX1, APP, CDC25B, CYP1A1, TERT 2.74553
[BP] GO:0051896 regulation of protein kinase B signaling AXL, KIT, MET, PIK3CA, PIK3CB, SRC, XDH 2.74096
[BP] GO:0007268 None HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 2.73997
[BP] GO:0098916 None HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 2.73997
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, APP, CDC25B, CYP1A1, PRKCA, TERT 2.70342
[BP] GO:0080090 regulation of primary metabolic process ADORA3, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CNR1, CYP1A1, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, FABP3, FABP4, FLT3, GLO1, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, JAK2, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A, XDH 2.66548
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, APP, AXL, BCL2, CA2, CYP19A1, HTR2B, JAK2, KCNH2, MMP12, PTGS2, SRC, TERT 2.65752
[BP] GO:0050999 None CNR1, CNR2, HTR2B, TERT 2.64493
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.64321
[BP] GO:0002682 regulation of immune system process ALOX15, APP, AXL, BCL2, CA2, CNR1, CNR2, CYP19A1, ESR1, JAK2, KIT, MMP12, MMP2, PIK3CA, PIK3CB, PRKCA, PTPN1, SRC 2.64321
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, DNMT1, HTR1B, IGF1R, MMP2, PTGS2, SRC 2.64321
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA3, APP, AURKB, BCL2, CDC25B, CNR1, CNR2, CYP1B1, ESR1, ESR2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, JAK2, KIT, MET, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS2, PTPN1, SRC, TERT, XDH 2.63902
[BP] GO:0043549 regulation of kinase activity APP, CDC25B, FABP4, FLT3, HTR2A, HTR2B, IGF1R, JAK2, KIT, PIK3CA, PIK3CB, PTPN1, SRC 2.60136
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.59546
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.59546
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.59546
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, KIT, MET, PIK3CA, PIK3CB, SRC 2.59081
[BP] GO:0051046 None ACHE, CNR1, CYP19A1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, JAK2, MMP12, PRKCA, SRC 2.56956
[BP] GO:0031324 negative regulation of cellular metabolic process APEX1, APP, AURKB, BCL2, CNR1, DNMT1, DYRK1A, ESR1, ESR2, FABP4, HTR1B, HTR1E, HTR2B, IGF1R, MET, MMP12, MMP9, PIK3CA, PRKCA, PTGS2, PTPN1, RORC, SRC, TERT, XDH 2.56715
[BP] GO:0051239 regulation of multicellular organismal process ADORA3, APP, AXL, BCL2, CA2, CNR1, CYP1B1, ESR1, HTR2A, HTR2B, HTR2C, JAK2, KCNH2, KDR, KIT, MET, MGLL, MMP12, MMP9, PIK3CA, PIM1, PRKCA, PTGS2, SRC, TERT, XDH 2.56715
[BP] GO:0051094 positive regulation of developmental process APP, AXL, BCL2, CA2, CNR1, CYP1B1, HTR2A, HTR2C, JAK2, KDR, KIT, PIM1, PRKCA, PTGS2, SRC, TERT 2.5574
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation IGF1R, JAK2, KDR, SRC 2.55271
[BP] GO:0045860 positive regulation of protein kinase activity CDC25B, FLT3, HTR2A, HTR2B, JAK2, KIT, PIK3CA, PIK3CB, PTPN1, SRC 2.53134
[BP] GO:0050730 None APP, FLT3, HTR2A, JAK2, KIT, PTPN1, SRC 2.52983
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MMP9, PTGS2, PTPN1, SRC 2.52983
[BP] GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress BCL2, CYP1B1, JAK2 2.52983
[BP] GO:0006939 None HTR1D, HTR2A, HTR2B, HTR7 2.5263
[BP] GO:0007154 None AXL, BCL2, CNR1, ESR2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PTGS2 2.5219
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DYRK1A, ESR1, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 2.52148
[BP] GO:0055080 cation homeostasis APP, BCL2, CA2, CA7, ESR1, HTR2A, HTR2B, HTR2C, JAK2, KCNH2, PIK3CB 2.51927
[BP] GO:0010518 positive regulation of phospholipase activity ESR1, HTR2A, HTR2B, KIT 2.49628
[BP] GO:0001101 response to acid chemical AKR1B1, DNMT1, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC 2.48837
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3 2.48837
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA3, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CNR1, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, FABP3, FABP4, FLT3, GLO1, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, JAK2, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A, XDH 2.48623
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, DYRK1A, FLT3, IGF1R, JAK2, KDR, KIT, MET, PRKCA, SRC, TOP2A 2.4858
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.48035
[BP] GO:0051338 regulation of transferase activity APP, AURKB, CDC25B, FABP4, FLT3, HTR2A, HTR2B, IGF1R, JAK2, KIT, PIK3CA, PIK3CB, PTPN1, SRC 2.46081
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, APP, DNMT1, HTR1B, IGF1R, MMP2, PTGS2, SRC 2.42012
[BP] GO:0045597 positive regulation of cell differentiation APP, AXL, BCL2, CA2, CNR1, HTR2A, HTR2C, JAK2, KDR, KIT, PRKCA, PTGS2, TERT 2.40538
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.40326
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, EBP, FLT3, KDR, KIT, TYR 2.40326
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CNR1, CYP1A1, HSD11B2, PTGS2, SRC, TYR 2.39444
[BP] GO:0055082 cellular chemical homeostasis APP, BCL2, CA2, CA7, ESR1, HTR2A, HTR2B, HTR2C, JAK2, PIK3CA, PIK3CB 2.38859
[BP] GO:0007610 None APP, BCL2, CNR1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, KIT, PTGS2 2.38779
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AURKB, AXL, BCL2, CNR1, DNMT1, ESR1, IGF1R, KDR, KIT, MET, MMP1, MMP9, SRC 2.3867
[BP] GO:0044283 None AKR1B1, ALOX15, ALOX5, CYP19A1, CYP1A1, EBP, MGLL, PTGS1, PTGS2 2.34619
[BP] GO:0032101 regulation of response to external stimulus CNR1, CNR2, CYP19A1, ESR1, FABP4, JAK2, KDR, MET, MGLL, MMP12, PRKCA, PTGS2 2.34146
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.34146
[BP] GO:0033674 positive regulation of kinase activity CDC25B, FLT3, HTR2A, HTR2B, JAK2, KIT, PIK3CA, PIK3CB, PTPN1, SRC 2.34124
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation FLT3, HTR2A, JAK2, KIT, PTPN1, SRC 2.33082
[BP] GO:0019725 cellular homeostasis APEX1, APP, BCL2, CA2, CA7, ESR1, HTR2A, HTR2B, HTR2C, JAK2, PIK3CA, PIK3CB 2.33082
[BP] GO:0032768 None CNR1, CNR2, HTR2B, TERT 2.32989
[BP] GO:0031347 regulation of defense response CNR1, CNR2, CYP19A1, ESR1, FABP4, JAK2, MGLL, MMP12, MMP2, PTGS2, PTPN1, SRC 2.32821
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, JAK2, MET, MMP9, SRC, TERT 2.32821
[BP] GO:0048585 negative regulation of response to stimulus ALOX15, BCL2, CNR1, CNR2, CYP19A1, DYRK1A, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TERT, XDH 2.313
[BP] GO:1904018 positive regulation of vasculature development CYP1B1, KDR, KIT, PRKCA, PTGS2, TERT 2.31282
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, JAK2, PIM1, RORC, SRC 2.31282
[BP] GO:0046686 response to cadmium ion CYP1A2, KIT, MMP9, TERT 2.30804
[BP] GO:0001525 angiogenesis CYP1B1, KDR, MMP2, PIK3CA, PIK3CB, PRKCA, PTGS2 2.30274
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.29707
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.29707
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, HSD11B2, IGF1R, PTGS2, SRC 2.28849
[BP] GO:0030168 platelet activation AXL, PIK3CA, PIK3CB, PRKCA, SRC 2.2838
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AXL, BCL2, CDC25B, CYP1A1, ESR1, FABP4, FLT3, FUT7, GLO1, HTR2B, JAK2, KDR, KIT, MET, MMP2, MMP9, PTGS2, RORC, SRC, TERT, TOP2A 2.27977
[BP] GO:0001666 response to hypoxia BCL2, CYP1A1, HSD11B2, MMP2, PTGS2, SRC, TERT 2.27863
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity FLT3, HTR2A, HTR2B, JAK2, KIT, PIK3CB, PTPN1, SRC 2.27747
[BP] GO:0050900 leukocyte migration CNR2, FUT7, KIT, MMP1, MMP9, PIK3CA, PIK3CB, SRC 2.27747
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, JAK2 2.27372
[BP] GO:0030003 cellular cation homeostasis APP, BCL2, CA2, CA7, ESR1, HTR2A, HTR2B, HTR2C, JAK2, PIK3CB 2.24788
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.24707
[BP] GO:0046883 regulation of hormone secretion CNR1, CYP19A1, HTR1A, HTR2A, HTR2C, JAK2, PRKCA 2.2457
[BP] GO:0051347 positive regulation of transferase activity AURKB, CDC25B, FLT3, HTR2A, HTR2B, JAK2, KIT, PIK3CA, PIK3CB, PTPN1, SRC 2.24435
[BP] GO:0010517 regulation of phospholipase activity ESR1, HTR2A, HTR2B, KIT 2.24124
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic CNR1, HTR1B, HTR2A, PTGS2 2.24124
[BP] GO:0038171 None CNR1, CNR2 2.24028
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.24028
[BP] GO:0014827 None HTR1D, HTR2B 2.24028
[BP] GO:0090087 None ACHE, APP, CA2, CNR1, HTR2B, HTR2C, JAK2, MMP12, PRKCA, PTGS2, PTPN1, SRC 2.23672
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AURKB, BACE1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, MGLL, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH 2.23461
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, MMP2, MMP9 2.23461
[BP] GO:0036293 response to decreased oxygen levels BCL2, CYP1A1, HSD11B2, MMP2, PTGS2, SRC, TERT 2.21926
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.20561
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.20561
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.19876
[BP] GO:0032268 regulation of cellular protein metabolic process ALOX15, APP, BCL2, CDC25B, DNMT1, DYRK1A, ESR1, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, JAK2, KDR, KIT, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, XDH 2.19612
[BP] GO:0048608 reproductive structure development AXL, BCL2, CYP19A1, ESR1, HSD17B2, KIT, SRC 2.19612
[BP] GO:0016042 lipid catabolic process AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, MGLL 2.19612
[BP] GO:0023052 None CNR1, ESR2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, KCNH2 2.19362
[BP] GO:0006873 cellular ion homeostasis APP, BCL2, CA2, CA7, ESR1, HTR2A, HTR2B, HTR2C, JAK2, PIK3CB 2.18752
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, BCL2, JAK2, KDR, PIK3CB, SRC 2.18752
[BP] GO:0030098 lymphocyte differentiation AXL, BCL2, FLT3, FUT7, KIT, RORC 2.18752
[BP] GO:0060193 positive regulation of lipase activity ESR1, HTR2A, HTR2B, KIT 2.18038
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA3, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, FABP3, FABP4, FLT3, GLO1, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, JAK2, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A, XDH 2.17792
[BP] GO:0001775 cell activation ALOX5, APP, AXL, BCL2, FLT3, FUT7, KIT, MMP9, PIK3CA, PIK3CB, PRKCA, RORC, SRC 2.17792
[BP] GO:0090066 None ALOX15, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 2.16614
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B2 2.16614
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.16614
[BP] GO:0045787 positive regulation of cell cycle APEX1, APP, AURKB, CDC25B, CYP1A1, PRKCA, SRC, TERT 2.15249
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.15249
[BP] GO:0034097 response to cytokine ALOX15, AXL, BCL2, FABP4, FLT3, JAK2, PRKCA, PTGS2, SRC 2.13833
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.12608
[BP] GO:0032103 positive regulation of response to external stimulus CNR1, FABP4, JAK2, KDR, MET, PRKCA, PTGS2 2.12608
[BP] GO:0019433 None FABP3, FABP4, MGLL 2.1186
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.11491
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, ESR1, HSD17B2, KIT, PTGS2, SRC 2.09239
[BP] GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling FLT3, JAK2, KDR, KIT 2.09239
[BP] GO:0006874 cellular calcium ion homeostasis APP, BCL2, ESR1, HTR2A, HTR2B, HTR2C, JAK2, PIK3CB 2.08422
[BP] GO:0043085 positive regulation of catalytic activity APP, AURKB, BCL2, CDC25B, ESR1, FLT3, HTR2A, HTR2B, JAK2, KIT, PIK3CA, PIK3CB, PTPN1, SRC, TERT, XDH 2.07446
[BP] GO:0014910 regulation of smooth muscle cell migration APEX1, BCL2, SRC, TERT 2.07136
[BP] GO:0071502 None HTR1B, HTR2B 2.06292
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.06292
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CNR1, CYP1B1, JAK2, MMP9, PIK3CB, PTGS2, SRC, TOP2A, XDH 2.05625
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, MGLL, PIM1, PTGS1, PTGS2, TYR 2.05218
[BP] GO:0051090 regulation of DNA binding transcription factor activity ADORA3, APP, CYP1B1, ESR1, ESR2, JAK2, KIT, PIM1 2.04103
[BP] GO:0050727 regulation of inflammatory response CNR1, CNR2, CYP19A1, ESR1, FABP4, JAK2, MGLL, PTGS2 2.04103
[BP] GO:0070482 response to oxygen levels BCL2, CYP1A1, HSD11B2, MMP2, PTGS2, SRC, TERT 2.03462
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1 2.03462
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CNR1, CYP1B1, JAK2, MMP9, PIK3CB, PTGS2, SRC, TOP2A, XDH 2.03131
[BP] GO:1900182 positive regulation of protein localization to nucleus APP, JAK2, PTGS2, SRC, TERT 2.01874
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, JAK2, RORC, SRC 2.01874
[BP] GO:1901992 positive regulation of mitotic cell cycle phase transition APEX1, APP, CYP1A1, TERT 2.0146
[BP] GO:0055074 calcium ion homeostasis APP, BCL2, ESR1, HTR2A, HTR2B, HTR2C, JAK2, PIK3CB 2.01372
[BP] GO:0071900 regulation of protein serine/threonine kinase activity FLT3, HTR2A, HTR2B, IGF1R, JAK2, KIT, PIK3CB, PTPN1, SRC 2.00386
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA3, ALOX15, ALPI, ALPL, APP, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, ESR1, FLT3, GLO1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, JAK2, KCNH2, KDR, KIT, MET, MGLL, MMP2, PIK3CA, PIK3CB, PIM1, PRKCA, PTPN1, SRC, TERT 7.70959
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA3, ALOX15, ALOX5, ALPI, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EBP, ESR1, FLT3, FUT7, GLO1, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, JAK2, KCNH2, KDR, KIT, MET, MGLL, MMP2, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS1, PTGS2, PTPN1, SRC, TERT, TYR 6.85173
[CC] GO:0044425 membrane part ABCB1, ACHE, ADORA3, ALOX15, ALPI, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EBP, ESR1, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, JAK2, KCNH2, KDR, KIT, MET, MGLL, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, SRC, TYR 6.15814
[CC] GO:0044459 plasma membrane part ABCB1, ADORA3, ALOX15, APP, AXL, BACE1, CA2, CA4, CA9, CNR1, CNR2, EBP, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, JAK2, KCNH2, KDR, KIT, MET, PTGS2, SRC 6.02797
[CC] GO:0031226 intrinsic component of plasma membrane ADORA3, APP, AXL, BACE1, CA4, CNR1, CNR2, EBP, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET 5.63699
[CC] GO:0005887 integral component of plasma membrane ADORA3, APP, AXL, BACE1, CNR1, CNR2, EBP, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET 5.30973
[CC] GO:0045121 membrane raft APP, BACE1, CNR1, HTR2A, JAK2, KDR, PTGS2, SRC 2.73091
[CC] GO:0098857 membrane microdomain APP, BACE1, CNR1, HTR2A, JAK2, KDR, PTGS2, SRC 2.71135
[CC] GO:0044432 endoplasmic reticulum part APP, BACE1, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EBP, FLT3, HSD11B1, HSD11B2, HSD17B2, MGLL, PTGS1, PTGS2, PTPN1 2.47123
[CC] GO:0098589 membrane region APP, BACE1, CNR1, HTR2A, JAK2, KDR, PTGS2, SRC 2.25428
[CC] GO:0005783 None APEX1, APP, BCL2, CA4, CYP19A1, EBP, FLT3, HTR5A, KDR, PRKCA, PTGS2, PTPN1, XDH 2.24028
[MF] GO:0004993 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.5366
[MF] GO:0099589 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.5366
[MF] GO:0043176 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 16.4544
[MF] GO:0051378 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 16.4544
[MF] GO:0099528 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 14.1159
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, ALPI, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESR2, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PRKCA, PTPN1, RORC, TYR, XDH 13.0601
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX15, ALOX5, ALPI, ALPL, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, FABP3, FABP4, FLT3, GLO1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, JAK2, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A, TYR, XDH 13.0601
[MF] GO:0008227 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 12.1529
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPI, ALPL, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESR2, GLO1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, JAK2, KIT, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PRKCA, PTGS1, PTGS2, PTPN1, RORC, TERT, TOP2A, TYR, XDH 10.9428
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 10.8661
[MF] GO:0003824 catalytic activity ABCB1, ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPI, ALPL, APEX1, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, EBP, FLT3, FUT7, GLO1, HSD11B1, HSD11B2, HSD17B2, IGF1R, JAK2, KCNH2, KDR, KIT, MET, MGLL, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS1, PTGS2, PTPN1, SRC, TERT, TOP2A, TYR, XDH 10.6637
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.99656
[MF] GO:0070405 ammonium ion binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 9.43389
[MF] GO:0030594 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 9.20804
[MF] GO:0038023 signaling receptor activity ADORA3, AXL, CNR1, CNR2, EBP, ESR1, ESR2, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, KIT, MET, RORC 7.38663
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CNR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, FLT3, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, JAK2, KDR, KIT, MET, NQO2, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, TOP2A 6.85173
[MF] GO:0008270 zinc ion binding ALPI, CA1, CA12, CA2, CA4, CA7, CA9, DNMT1, ESR1, ESR2, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PRKCA, PTPN1, RORC 6.77104
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.57234
[MF] GO:0004872 receptor activity ADORA3, AXL, CNR1, CNR2, EBP, ESR1, ESR2, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, KIT, MET, RORC 6.43926
[MF] GO:0060089 molecular transducer activity ADORA3, AXL, CNR1, CNR2, EBP, ESR1, ESR2, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, KIT, MET, RORC 6.21844
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.1558
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 5.94681
[MF] GO:0004871 signal transducer activity ADORA3, AXL, CNR1, CNR2, EBP, ESR1, ESR2, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, KIT, MET, RORC 5.72937
[MF] GO:0099600 transmembrane receptor activity ADORA3, AXL, CNR1, CNR2, EBP, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET 5.46229
[MF] GO:0004888 transmembrane signaling receptor activity ADORA3, AXL, CNR1, CNR2, EBP, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET 5.46229
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPI, ALPL, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESR2, GLO1, JAK2, KIT, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PRKCA, PTGS1, PTGS2, PTPN1, RORC, TERT, TOP2A, TYR, XDH 5.24042
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, JAK2, PTGS1, PTGS2, SRC 5.04003
[MF] GO:0004713 protein tyrosine kinase activity AXL, DYRK1A, FLT3, IGF1R, JAK2, KDR, KIT, MET, SRC 5.04003
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1 4.98609
[MF] GO:0043560 insulin receptor substrate binding IGF1R, JAK2, PIK3CA, PIK3CB 4.85884
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, JAK2, PTGS1, PTGS2, SRC 4.8389
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.53918
[MF] GO:0004672 protein kinase activity AURKB, AXL, DYRK1A, FLT3, IGF1R, JAK2, KCNH2, KDR, KIT, MET, PIK3CA, PIM1, PRKCA, SRC 4.34229
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, DYRK1A, FLT3, IGF1R, JAK2, KCNH2, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, PRKCA, SRC 4.18621
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 3.99806
[MF] GO:0042802 identical protein binding ACHE, APP, BCL2, DYRK1A, ESR1, ESR2, FLT3, IGF1R, JAK2, KCNH2, KDR, KIT, MET, MGLL, MMP9, NQO2, PTGS2, TERT, TOP2A, TYR, XDH 3.82311
[MF] GO:0016301 kinase activity AURKB, AXL, DYRK1A, FLT3, IGF1R, JAK2, KCNH2, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, PRKCA, SRC 3.75445
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.6348
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, DYRK1A, FLT3, IGF1R, JAK2, KCNH2, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, TERT 3.58736
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TYR 3.48721
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.44949
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B2, JAK2, NQO2, PTGS1, PTGS2, SRC, XDH 3.42454
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 3.41242
[MF] GO:1901363 heterocyclic compound binding ABCB1, APEX1, APP, AURKB, AXL, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, FLT3, HSD11B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, JAK2, KDR, KIT, MET, MMP12, NQO2, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A, XDH 3.21594
[MF] GO:0097159 organic cyclic compound binding ABCB1, APEX1, APP, AURKB, AXL, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, FLT3, HSD11B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, JAK2, KDR, KIT, MET, MMP12, NQO2, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A, XDH 3.15782
[MF] GO:0004930 None ADORA3, CNR1, CNR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 3.08059
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.87687
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.87687
[MF] GO:0003845 None HSD11B1, HSD11B2 2.87687
[MF] GO:0071886 None HTR2A, HTR2C 2.87687
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B2, XDH 2.82505
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.61341
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.52983
[MF] GO:0035173 histone kinase activity AURKB, JAK2, PRKCA 2.52983
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.48035
[MF] GO:0004949 None CNR1, CNR2 2.48035
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, NQO2, XDH 2.31282
[MF] GO:0042803 protein homodimerization activity ACHE, BCL2, FLT3, KCNH2, KIT, MGLL, NQO2, PTGS2, TERT, TOP2A, TYR, XDH 2.30578
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.24028
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B2 2.16614
[MF] GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity KIT, MET, PIK3CA, PIK3CB 2.09239
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX15, ALOX5, PTGS2 2.07432
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.06292
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B2 2.03521
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX15, ALOX5, PTGS2 2.03521
[MF] GO:0052813 phosphatidylinositol bisphosphate kinase activity KIT, MET, PIK3CA, PIK3CB 2.03462


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Serotonergic synapse_Homo sapiens_hsa04726 APP, HTR1E, ALOX15, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, PRKCA, HTR2A, PTGS2, HTR5A, HTR4, PTGS1, HTR6, HTR7, ALOX5 19.9431
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 HTR1E, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, HTR2A, HTR5A, HTR4, HTR6, HTR7, CNR2, CNR1, ADORA3 9.761
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.7959
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 7.4309
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PRKCA, PIK3CB, MMP9, MET, ESR1, IGF1R 6.7585
Pathways in cancer_Homo sapiens_hsa05200 PIK3CA, FLT3, MMP1, MMP2, KIT, BCL2, PRKCA, PIK3CB, PTGS2, MMP9, MET, IGF1R 6.0645
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 7.06
MicroRNAs in cancer_Homo sapiens_hsa05206 DNMT1, ABCB1, PIK3CA, BCL2, PIM1, CYP1B1, PRKCA, PTGS2, MMP9, MET, CDC25B 6.3167
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, HTR2B, HTR2C, PRKCA, PIK3CB, HTR2A 5.8022
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, BCL2, PIM1, PRKCA, PIK3CB, JAK2 5.8022
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, PIK3CB, PTGS2, MGLL, PTGS1 5.8365
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, CNR1, KIT, KDR, PRKCA, PIK3CB, MET, IGF1R 5.8022
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, ESR2 5.8022
Metabolic pathways_Homo sapiens_hsa01100 DNMT1, ALOX15, AKR1B1, PTGS2, TYR, CYP19A1, PTGS1, HSD11B1, EBP, FUT7, AKR1B10, ALOX5, HSD17B2, CYP1A2, CYP1A1, ALPL, ALPI, XDH, MGLL 5.6702
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PRKCA, PIK3CB, PTGS2 5.8022
Calcium signaling pathway_Homo sapiens_hsa04020 HTR6, HTR7, HTR2B, HTR2C, PRKCA, HTR2A, HTR5A, HTR4 5.3151
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, JAK2, ESR1, ESR2 5.4255
cAMP signaling pathway_Homo sapiens_hsa04024 HTR6, PIK3CA, HTR1E, HTR1D, HTR1A, HTR1B, PIK3CB, HTR4 5.0104
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, BCL2, PRKCA, PIK3CB, MET, IGF1R 4.9851
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, PIK3CA, KIT, KDR, PRKCA, PIK3CB, MET, IGF1R 4.6501
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, PIK3CA, BCL2, PRKCA, PIK3CB, JAK2 4.4549
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 PIK3CA, KIT, KDR, BCL2, PRKCA, PIK3CB, JAK2, MET, IGF1R 4.3165
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, KIT, PIM1, PIK3CB 4.6501
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, KIT, PIK3CB, MET 4.3479
Hepatitis B_Homo sapiens_hsa05161 PIK3CA, SRC, BCL2, PRKCA, PIK3CB, MMP9 3.8778
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, BCL2, PRKCA, PIK3CB, IGF1R 3.5533
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1, PTGS2 3.9698
Gap junction_Homo sapiens_hsa04540 SRC, HTR2B, HTR2C, PRKCA, HTR2A 3.8681
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB, JAK2 3.3168
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PRKCA, PIK3CB, ESR1 3.3168
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PRKCA, PIK3CB, MMP9 3.3168
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, BCL2, PRKCA, PIK3CB 3.3048
Glioma_Homo sapiens_hsa05214 PIK3CA, PRKCA, PIK3CB, IGF1R 3.2614
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, PIK3CA, PRKCA, PIK3CB 3.9851
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, PIK3CB, JAK2 2.8671
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.9307
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PRKCA, PIK3CB, PTGS2 2.8671
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB, MET, IGF1R 3.1357
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, PTGS2, PTGS1 3.3168
Taste transduction_Homo sapiens_hsa04742 HTR1E, HTR1D, HTR1A, HTR1B 2.9176
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PRKCA, PIK3CB 2.8671
Adherens junction_Homo sapiens_hsa04520 PTPN1, SRC, MET, IGF1R 3.0884
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A2, CYP1A1, CYP1B1 3.1002
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, BCL2, PIK3CB, PTGS2 2.869
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB, IGF1R 2.8508
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 3.0109
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 2.7104
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.5394
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1, PRKCA, PTGS2, MGLL 2.6698
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.3891
Endocytosis_Homo sapiens_hsa04144 SRC, KIT, KDR, MET, IGF1R 2.0655
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 PIK3CA, PIK3CB, JAK2, IGF1R 2.2017
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, KIT, PRKCA, PIK3CB 2.194
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PRKCA, PIK3CB 2.1647
Influenza A_Homo sapiens_hsa05164 PIK3CA, PRKCA, PIK3CB, JAK2 1.9252
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.8928
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB, JAK2 1.8671
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, PRKCA 1.8928
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PRKCA, PIK3CB 2.1959
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PRKCA, PIK3CB 1.8788
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB, IGF1R 1.8719
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PRKCA, PIK3CB 2.3148
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB, IGF1R 2.2494
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.2185
Non-small cell lung cancer_Homo sapiens_hsa05223 PIK3CA, PRKCA, PIK3CB 2.3856
Melanogenesis_Homo sapiens_hsa04916 KIT, PRKCA, TYR 1.8327
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, BCL2, PIK3CB 1.6386
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PRKCA, PIK3CB 1.8398
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, PIK3CB 1.7464
Colorectal cancer_Homo sapiens_hsa05210 PIK3CA, BCL2, PIK3CB 2.2814
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PRKCA, PIK3CB 1.8327
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PRKCA, PIK3CB 1.8262
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET 1.4551
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB, IGF1R 1.6057
Herpes simplex infection_Homo sapiens_hsa05168 JAK2 0.2871
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2994
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.5072
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3091
Measles_Homo sapiens_hsa05162 PIK3CA, PIK3CB, JAK2 1.529
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB, IGF1R 1.5449
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PRKCA, PIK3CB 1.5327
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, PIK3CB 1.5089
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1, MGLL 2.328
Wnt signaling pathway_Homo sapiens_hsa04310 PRKCA 0.3615
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, PIK3CB 1.3341
Epstein-Barr virus infection_Homo sapiens_hsa05169 PIK3CA, BCL2, PIK3CB 1.1649
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.3983
Axon guidance_Homo sapiens_hsa04360 MET 0.393
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3983
Dopaminergic synapse_Homo sapiens_hsa04728 PRKCA 0.3905
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2, JAK2 1.2861
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, SRC, PIK3CB 1.1593
MAPK signaling pathway_Homo sapiens_hsa04010 PRKCA, CDC25B 0.5306
Vascular smooth muscle contraction_Homo sapiens_hsa04270 PRKCA 0.4038
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1 2.1919
Glutamatergic synapse_Homo sapiens_hsa04724 PRKCA 0.4187
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 PIK3CA, SRC, PIK3CB 1.1236
HTLV-I infection_Homo sapiens_hsa05166 PIK3CA, TERT, PIK3CB 0.9535
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB 0.8147
Alzheimer's disease_Homo sapiens_hsa05010 BACE1, APP 0.7533
Tight junction_Homo sapiens_hsa04530 SRC, PRKCA 0.8636
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.8867
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB 0.8851
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4802
Circadian entrainment_Homo sapiens_hsa04713 PRKCA 0.4802
Morphine addiction_Homo sapiens_hsa05032 PRKCA 0.49
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4911
Salivary secretion_Homo sapiens_hsa04970 PRKCA 0.4923
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 1.0394
Insulin secretion_Homo sapiens_hsa04911 PRKCA 0.5061
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB 1.0501
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.0501
Peroxisome_Homo sapiens_hsa04146 XDH 0.5119
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 PRKCA 0.518
Pancreatic secretion_Homo sapiens_hsa04972 CA2, PRKCA 1.1037
NF-kappa B signaling pathway_Homo sapiens_hsa04064 BCL2, PTGS2 1.1236
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 1.1593
GABAergic synapse_Homo sapiens_hsa04727 SRC, PRKCA 1.1593
Adipocytokine signaling pathway_Homo sapiens_hsa04920 JAK2 0.5635
Thyroid hormone synthesis_Homo sapiens_hsa04918 PRKCA 0.5611
Long-term potentiation_Homo sapiens_hsa04720 PRKCA 0.5766
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2 0.5659
Amphetamine addiction_Homo sapiens_hsa05031 PRKCA 0.574
Chronic myeloid leukemia_Homo sapiens_hsa05220 PIK3CA, PIK3CB 1.2861
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.2861
Shigellosis_Homo sapiens_hsa05131 SRC 0.5794
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.5794
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.2912
Leishmaniasis_Homo sapiens_hsa05140 PTGS2, JAK2 1.2861
Gastric acid secretion_Homo sapiens_hsa04971 CA2, PRKCA 1.2794
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2 1.2912
Pancreatic cancer_Homo sapiens_hsa05212 PIK3CA, PIK3CB 1.3341
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.763
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.317
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.3397
Long-term depression_Homo sapiens_hsa04730 PRKCA, IGF1R 1.3998
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 PRKCA 0.6375
Vibrio cholerae infection_Homo sapiens_hsa05110 PRKCA 0.6639
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6639
Malaria_Homo sapiens_hsa05144 MET 0.6733
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB 1.5072
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6951
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, PIK3CB 1.5449
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 PRKCA, ESR1 1.5561
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.7062
Cysteine and methionine metabolism_Homo sapiens_hsa00270 DNMT1 0.7005
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.587
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.7409
African trypanosomiasis_Homo sapiens_hsa05143 PRKCA 0.7881
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8236
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.7881
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8671
Base excision repair_Homo sapiens_hsa03410 APEX1 0.8052
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.8788
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8327
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7523
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8817
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8336
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8697
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0508
Steroid biosynthesis_Homo sapiens_hsa00100 EBP 0.9759
Folate biosynthesis_Homo sapiens_hsa00790 ALPL, ALPI 2.3891
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.1828


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)