TCM Prescription: Fu Yan Shu Capsules



Prescription Description
Prescription IDTCMF7219
Pinyin NameFu Yan Shu Jiao Nang
Chinese Name妇炎舒胶囊
English NameFu Yan Shu Capsules
Function Description清热凉血, 活血止痛。用于妇女盆腔炎症等引起的带下量多, 腹痛。
IndicationsAbdominal pain disorder, Pelvic inflammatory diseases
Disease ICD-11 Category SA58 [Abdominal pain disorder (TM1), 腹痛 (TM1) ];
GA05 [Female pelvic inflammatory diseases, 女性盆腔炎性疾病 ];
Human Tissues Associated with IndicationUterus
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH385 Sargentodoxa cuneata 大血藤 TCMH385 ITSAG360-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH381 Isatis indigotica 大青叶 TCMH381 KJ765825
TCMH1632 Taraxacum mongolicum 蒲公英 TCMH1632 ITSAG679-14
TCMH258 Paeonia obovata 赤芍 TCMH258 GBVX7902-15
TCMH363 Rheum officinale 大黄 TCMH363 ITSAJ4685-14
TCMH407 Salvia miltiorrhiza 丹参 TCMH407 ITSAH2408-14
TCMH921 Polygonum cuspidatum 虎杖 TCMH921 ITSAI2369-14
TCMH284 Melia toosendan 川楝子 TCMH284 KY197925
TCMH1714 Lonicera japonica 忍冬藤 TCMH1714 ITSAI3881-14
TCMH2376 Corydalis yanhusuo 延胡索 TCMH2376
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT132 BCHE Butyrylcholinesterase Hydrolase P06276
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT188 DHFR Dihydrofolate reductase Oxidoreductase P00374
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT211 CES1 Acyl coenzyme A:cholesterol acyltransferase Transferase P23141
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT265 GSK3B Glycogen synthase kinase-3 beta Kinase P49841
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT575 PLA2G2A Phospholipase A2 group IIA Hydrolase P14555
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT615 SENP8 Sentrin-specific protease 8 Protease Q96LD8
TCMT616 SENP7 Sentrin-specific protease 7 Protease Q9BQF6
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT633 SLC6A4 Serotonin transporter Transporter P31645
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT643 ADRA1A Alpha-1a adrenergic receptor GPCR P35348
TCMT645 HTR1E Serotonin 1e (5-HT1e) receptor GPCR P28566
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT783 NR3C2 Mineralocorticoid receptor Nuclear receptor P08235
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT815 HTR1D Serotonin 1d (5-HT1d) receptor GPCR P28221
TCMT816 HTR1B Serotonin 1b (5-HT1b) receptor GPCR P28222
TCMT817 HTR4 Serotonin 4 (5-HT4) receptor GPCR Q13639
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT853 SIGMAR1 Sigma opioid receptor Unclassified Q99720
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT904 PGR Progesterone receptor Nuclear receptor P06401
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1168 Trichomonas vaginalis
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1183 Candida albicans SC5314
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1206 Influenza A virus (A/PR/8/34(H1N1))
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1241 Human rhinovirus 14
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1285 Human coxsackievirus B3
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1333 Human rhinovirus 1A
TCMT1346 Helicobacter pylori
TCMT1347 Human rhinovirus 16
TCMT1348 Human rhinovirus 2
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1405 Penicillium citrinum
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0042221 response to chemical ADRA1A, ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AXL, BCHE, BCL2, CA2, CA9, CDK6, CES1, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DRD1, DRD2, DRD3, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GSK3B, HSD11B2, HSD17B2, HSPA1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IDO1, IGF1R, INSR, KCNH2, KDR, MMP2, MMP9, NR3C1, PIK3CA, PPARA, PTGS2, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TYR 19.9271
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA1A, ADRA2A, AKR1B1, ALOX15, APEX1, APP, AR, AURKB, AXL, BCHE, BCL2, CA12, CA2, CA7, CDK6, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, DHFR, DRD1, DRD2, DRD3, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, GPR35, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR4, HTR7, INSR, KCNH2, KDR, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 18.2542
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, APP, AR, AXL, BCHE, BCL2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DRD1, DRD2, DRD3, EGFR, ESR1, ESRRA, FABP3, GSK3B, HSD11B2, HSD17B2, HTR1B, HTR5A, IDO1, IGF1R, INSR, MMP2, MMP9, NR3C1, PIK3CA, PPARA, PTGS2, RORC, SLC6A4, SRC, TEK, TYR 17.7635
[BP] GO:0010033 response to organic substance ADRA1A, ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AXL, BCHE, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DRD1, DRD2, DRD3, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GSK3B, HSD11B2, HSD17B2, HSPA1A, HTR1B, HTR5A, IDO1, IGF1R, INSR, KDR, MMP2, NR3C1, PIK3CA, PPARA, PTGS2, RORC, SLC6A4, SMAD3, SRC, TEK, TYR 17.0743
[BP] GO:0007210 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 15.3009
[BP] GO:0098664 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 15.3009
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, APP, AR, BCHE, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, F3, FABP3, FLT3, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, IDO1, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PGR, PIM1, PTGS1, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 15.1364
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA1A, ADRA2A, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, FLT3, GPR35, GSK3B, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 15.0383
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA1A, ADRA2A, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, FLT3, GPR35, GSK3B, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 14.9902
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, APP, AR, BCHE, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DRD1, DRD2, DRD3, EGFR, ESR1, ESRRA, FLT3, HSD11B2, HTR1B, HTR5A, NR3C1, PTGS2, RORC, SLC6A4, SRC, TEK, TYR 14.923
[BP] GO:0042493 response to drug ADRA1A, AKR1B1, APEX1, AXL, BCHE, BCL2, CA9, CDK6, CNR1, CNR2, CYP1A1, CYP1B1, DHFR, DRD1, DRD2, DRD3, EGFR, FABP3, HSD11B2, HTR1B, HTR2A, HTR2B, HTR2C, KCNH2, KDR, NR3C1, PTGS2, SLC6A2, SLC6A4, SRC 13.8195
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AURKB, AXL, BCHE, BCL2, CA2, CA6, CA9, CDK6, CES1, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DRD1, DRD2, DRD3, EGFR, ESR1, ESRRA, F10, F3, FABP3, FABP4, FLT3, GSK3B, HSD11B2, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IDO1, IGF1R, INSR, KCNH2, KDR, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TYR 13.3265
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA1A, ADRA2A, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, F10, F3, FLT3, GPR35, GSK3B, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 13.165
[BP] GO:0033993 response to lipid ALPL, AR, AXL, BCHE, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, HTR1B, HTR5A, IDO1, NR3C1, PTGS2, RORC, SLC6A4, SRC, TYR 13.15
[BP] GO:0009719 response to endogenous stimulus ADRA1A, ADRA2A, AKR1B1, ALPL, APEX1, APP, AR, BCHE, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DRD1, EGFR, ESR1, ESRRA, FABP3, FLT3, GSK3B, HSD11B2, HTR1B, HTR5A, IGF1R, INSR, MMP2, NR3C1, PPARA, PTGS2, SLC6A4, SMAD3, SRC, TEK 13.138
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA1A, ADRA2A, AKR1B1, ALOX15, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FLT3, GPR35, GSK3B, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IDO1, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 13.0239
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA1A, ADRA2A, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AR, AXL, BCHE, BCL2, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESRRB, F10, F3, FABP4, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR7, IDO1, IGF1R, INSR, KCNH2, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TNKS2, TYR 12.3297
[BP] GO:0009725 response to hormone ADRA1A, ADRA2A, AKR1B1, ALPL, APEX1, AR, BCHE, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, INSR, NR3C1, PPARA, PTGS2, SLC6A4, SRC, TEK 12.2729
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA1A, ADRA2A, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCHE, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, GSK3B, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 12.1286
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA1A, ADRA2A, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCHE, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, GSK3B, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 11.9015
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA1A, ADRA2A, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, ESRRA, F10, F3, FABP4, FLT3, GPR35, GSK3B, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IDO1, INSR, KDR, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 11.5699
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA1A, ADRA2A, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CYP1B1, DRD2, EGFR, F10, F3, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 11.5699
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCHE, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DHFR, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR2B, HTR2C, IDO1, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 11.5313
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CBR1, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD2, EGFR, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 11.5294
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DHFR, FABP3, FUT7, GBA2, GLO1, HSPA1A, HTR2B, HTR2C, IDO1, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TYR, XDH 11.5093
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA1A, ADRA2A, AKR1B1, ALOX15, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DHFR, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GPR35, GSK3B, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IDO1, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 11.4903
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DHFR 11.4606
[BP] GO:0007187 None ADORA1, ADRA1A, ADRA2A, CNR1, CNR2, DRD1, DRD2, DRD3, HTR1A, HTR1B, HTR1D, HTR1E, HTR4, HTR5A, HTR6, HTR7 11.2908
[BP] GO:0003018 None ADORA1, ADRA1A, ADRA2A, DRD1, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SLC6A4, SRC, TEK 11.1156
[BP] GO:0097756 None ADORA1, ADRA1A, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SLC6A4 11.1156
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, APEX1, APP, AR, AURKB, AXL, BCHE, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DHFR, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPR35, GSK3B, HSPA1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IDO1, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, NR3C1, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 10.6658
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.5649
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCHE, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DHFR, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GSK3B, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR2B, HTR2C, IDO1, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP2, NQO2, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 10.5649
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AURKB, AXL, BCHE, BCL2, CA2, CA9, CBR1, CDC25B, CDK6, CES1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DRD1, DRD2, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, GSK3B, HSD11B1, HSD17B2, HTR2A, HTR2B, HTR5A, INSR, KDR, MET, MMP2, MMP9, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RORC, SIGMAR1, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS2, TOP2A, TYR 10.2756
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA1A, ADRA2A, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DUSP3, EGFR, ESR1, F10, F3, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 10.0687
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ADRA2A, ALOX15, APEX1, APP, AR, AXL, BCL2, CA2, CA7, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, GPR35, GSK3B, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KCNH2, KDR, MET, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TEK, TERT 10.0461
[BP] GO:0097746 None ADORA1, ADRA1A, ADRA2A, DRD1, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SLC6A4 9.86494
[BP] GO:0035296 None ADORA1, ADRA1A, ADRA2A, DRD1, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SLC6A4 9.86494
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, GSK3B, HSPA1A, HTR1B, IGF1R, INSR, KCNH2, KDR, MMP2, MMP9, NR3C1, PIK3CA, PTGS2, RORC, SLC6A4, SMAD3, SRC, TERT 9.85466
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADRA2A, AURKB, BCL2, CA2, CA7, CDK6, CNR1, DRD1, DRD2, DRD3, EGFR, HTR2A, HTR2B, HTR2C, KDR, PIK3CB, PTGS2, SRC, TNKS, TNKS2 9.79829
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, ALOX15, APEX1, APP, AR, AURKB, AXL, BCHE, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DHFR, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPR35, GSK3B, HSPA1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IDO1, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, NR3C1, PGR, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 9.79829
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, GSK3B, HSPA1A, HTR2B, IDO1, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SIGMAR1, SMAD3, SRC, TEK, TERT, TOP2A, XDH 9.59653
[BP] GO:0050880 None ADORA1, ADRA1A, ADRA2A, DRD1, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SLC6A4 9.55973
[BP] GO:0035150 None ADORA1, ADRA1A, ADRA2A, DRD1, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SLC6A4 9.52369
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, AR, BCL2, CDC25B, CDK6, CSNK2A1, DRD2, DRD3, EGFR, ESR1, F3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, PIM1, PTGS2, TEK, TERT 9.4992
[BP] GO:0003013 None ADORA1, ADRA1A, ADRA2A, DRD1, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SLC6A4, SRC, TEK 9.47601
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRA1A, ADRA2A, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DHFR, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, F10, F3, FABP4, FLT3, GPR35, GSK3B, HSPA1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IDO1, IGF1R, INSR, KDR, MET, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 9.47259
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CES1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 9.45032
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, GSK3B, HSPA1A, HTR2B, IDO1, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SIGMAR1, SMAD3, SRC, TEK, TERT, TOP2A, XDH 9.41266
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, BCHE, CNR1, CNR2, DHFR, DRD1, DRD2, DRD3, EGFR, FABP3, FLT3, GSK3B, HSD11B2, HTR1B, IGF1R, INSR, MMP2, PPARA, PTGS2, SLC6A4, SRC, TEK, TYR 9.33647
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, ADRA1A, APP, BCHE, CA2, CA7, CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, HTR1B, HTR2A, PTGS2, SLC6A4 9.24718
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, ADRA1A, APP, BCHE, CA2, CA7, CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, HTR1B, HTR2A, PTGS2, SLC6A4 9.24718
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, GSK3B, HSPA1A, HTR2B, IDO1, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SIGMAR1, SMAD3, SRC, TEK, TERT, TOP2A, XDH 9.06989
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, BCHE, CNR2, DRD1, DRD2, HTR1B, HTR2A, PTGS2, SLC6A4 9.00962
[BP] GO:0042310 None ADRA1A, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, SLC6A4 8.95952
[BP] GO:0042592 homeostatic process ADORA1, ADRA1A, ADRA2A, AKR1B1, APEX1, APP, AXL, BCL2, CA12, CA2, CA7, CNR1, DRD1, DRD2, DRD3, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, HTR2A, HTR2B, HTR2C, INSR, KCNH2, MET, PIK3CA, PIK3CB, SMAD3, SRC, TERT 8.84085
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA1A, ADRA2A, AR, BCHE, BCL2, CNR2, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, GPR35, GSK3B, HSPA1A, HTR1B, HTR2A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TERT, XDH 8.76777
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA1A, ADRA2A, ALOX15, APP, AR, BCL2, CDC25B, DRD1, DRD2, DRD3, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 8.75415
[BP] GO:0007188 None ADORA1, ADRA1A, ADRA2A, CNR1, DRD1, DRD2, DRD3, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 8.74817
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA1A, ADRA2A, AR, BCHE, BCL2, CNR2, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, GPR35, GSK3B, HSPA1A, HTR1B, HTR2A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TERT, XDH 8.74817
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ADRA2A, APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, HTR1D, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 8.72671
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, BCHE, CNR1, CNR2, DHFR, DRD1, DRD2, DRD3, EGFR, FABP3, FLT3, GSK3B, HSD11B2, HTR1B, IGF1R, INSR, MMP2, PPARA, PTGS2, SLC6A4, SRC, TEK, TYR 8.69278
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA1A, ADRA2A, ALOX15, APP, AR, BCL2, CDC25B, DRD1, DRD2, DRD3, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 8.67793
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AXL, BCL2, CDK6, CYP1A1, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, GSK3B, HTR1B, IGF1R, INSR, KDR, MMP2, NR3C1, PIK3CA, PTGS2, RORC, SLC6A4, SMAD3, SRC 8.64722
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, ADRA1A, CA2, CA7, CNR1, CNR2, DRD2, HTR1B 8.63123
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, PTGS1, PTGS2 8.59716
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA1A, ADRA2A, ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GSK3B, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 8.57467
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA1A, ADRA2A, ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DHFR, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GSK3B, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 8.55025
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA1A, ADRA2A, ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GSK3B, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 8.52493
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, APP, AR, AXL, BCL2, CA1, CA2, CDK6, CNR1, CNR2, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GSK3B, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNH2, KDR, MET, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTPN1, RORC, SIGMAR1, SMAD3, SRC, TEK, TNKS, TNKS2 8.45595
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CES1, CNR1, CNR2, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, HTR1B, HTR1D, KDR, SLC6A4, SRC 8.35359
[BP] GO:0007193 None ADORA1, ADRA2A, DRD2, DRD3, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 8.33135
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, PTGS1, PTGS2 8.2967
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, PTGS1, PTGS2 8.28081
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA1A, ADRA2A, ALOX15, APP, AR, BCL2, CDC25B, DRD1, DRD2, EGFR, ESRRB, FABP3, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 8.24505
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA1A, ADRA2A, ALOX15, APP, AR, BCL2, CDC25B, DRD1, DRD2, EGFR, ESRRB, FABP3, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 8.24505
[BP] GO:0048878 chemical homeostasis ADRA1A, ADRA2A, AKR1B1, APP, BCL2, CA12, CA2, CA7, CNR1, DRD1, DRD2, DRD3, EGFR, ESR1, FABP3, FABP4, GPR35, HTR2A, HTR2B, HTR2C, INSR, KCNH2, MET, PIK3CA, PIK3CB, SMAD3 8.23849
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, GSK3B, HSPA1A, HTR2B, IDO1, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 8.23849
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, GSK3B, HSPA1A, HTR2B, IDO1, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 8.17424
[BP] GO:0043271 negative regulation of ion transport ADORA1, ADRA2A, BCL2, CNR1, DRD2, DRD3, GPR35, HTR1B, HTR2A, KCNH2, MMP9, PTGS2 8.12508
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, ADRA1A, ADRA2A, APP, CA2, CNR1, CNR2, DRD1, DRD2, DRD3, ESR1, GPR35, GSK3B, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, INSR, PIK3CA, PIK3CB, SIGMAR1, SRC 8.10707
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA1A, ADRA2A, ALOX15, APP, AR, AURKB, BCL2, CDC25B, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GSK3B, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 8.06293
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DHFR, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, NQO2, PTGS1, PTGS2, TYR, XDH 7.97577
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ADRA2A, APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 7.95511
[BP] GO:0006805 xenobiotic metabolic process BCHE, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, NQO2, PTGS1, RORC 7.90598
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA1A, ADRA2A, APP, AR, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, DHFR, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GSK3B, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH 7.86799
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ADRA2A, APEX1, APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 7.71945
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD2, DRD3, EGFR, ESR1, GSK3B, HTR7, PGR, PPARA, RORC, SLC6A4, SRC, TOP2A 7.68216
[BP] GO:0050795 None ADORA1, CNR1, DRD2, DRD3, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B 7.64823
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, GSK3B, HSPA1A, HTR2B, IDO1, IGF1R, KDR, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 7.64648
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA1A, ADRA2A, ALOX15, APP, AR, DRD2, EGFR, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, PIK3CB, PTPN1, SRC, TEK, XDH 7.63718
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP4, KDR, MMP9, PTGS2, SRC, TERT 7.46104
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ADRA2A, ALOX15, APP, AXL, BCL2, CA2, CA7, CNR1, CYP19A1, DRD1, DRD2, DRD3, EGFR, GPR35, GSK3B, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, INSR, KCNH2, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TERT 7.43768
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DHFR, DRD1, DRD2, DUSP3, EGFR, FLT3, GSK3B, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TEK, TNKS, XDH 7.42963
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CBR1, CES1, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD2, EGFR, FABP3, FABP4, FUT7, GBA2, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 7.35302
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA1A, ADRA2A, ALOX15, AR, BCL2, CDK6, CNR1, CNR2, CYP19A1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, GSK3B, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 7.34209
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA1A, ADRA2A, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, GSK3B, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 7.34209
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, RORC, SRC 7.342
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, BCHE, CYP1B1, DHFR, DRD1, DRD2, DRD3, EGFR, HTR1A, INSR, PTGS2, SLC6A2, SLC6A4, SMAD3 7.31203
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DHFR, DRD1, EGFR, ESR1, FABP4, FLT3, GSK3B, HSPA1A, HTR1B, IGF1R, INSR, KCNH2, KDR, MMP2, MMP9, NR3C1, NUAK1, PIK3CA, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TERT, TOP2A 7.30161
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ADRA2A, APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 7.29542
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, DRD3, EGFR, F10, F3, INSR, MET, PIK3CA, PIK3CB, SRC, TEK, XDH 7.28378
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA1A, ADRA2A, ALOX15, APP, AR, BCL2, CDC25B, DRD2, EGFR, ESRRB, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 7.15507
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR 7.06056
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, DRD1, DRD2, DRD3, EGFR, HSD11B2, HSPA1A, HTR1B, HTR2A, HTR2B, MMP2, PPARA, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT, TYR 7.03521
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DHFR, DRD1, DRD2, DUSP3, EGFR, FLT3, GSK3B, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TEK, TNKS, XDH 6.92465
[BP] GO:0030335 positive regulation of cell migration ADRA2A, APP, BCL2, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 6.90621
[BP] GO:0080134 regulation of response to stress ADORA1, ADRA2A, APP, CDK6, CNR1, CNR2, CYP19A1, DHFR, DRD2, DUSP3, EGFR, ESR1, F3, FABP4, GSK3B, HSPA1A, IDO1, IGF1R, MET, MMP12, MMP2, NUAK1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 6.89588
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADRA2A, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, DRD2, EGFR, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2C 6.85499
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA1A, ADRA2A, ALOX15, APP, AR, BCL2, CDC25B, DRD2, EGFR, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 6.83541
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA1A, ADRA2A, ALOX15, APP, AR, DRD2, DUSP3, EGFR, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, PIK3CB, PTPN1, SRC, TEK, XDH 6.82222
[BP] GO:0007198 None HTR1A, HTR1B, HTR5A, HTR7 6.789
[BP] GO:0003008 None ADORA1, ADRA1A, ADRA2A, AKR1B1, APP, BCHE, BCL2, CNR1, CNR2, CYP1B1, DRD1, DRD2, DRD3, EGFR, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, INSR, KCNH2, PIK3CA, PTGS2, SLC6A4, SRC, TEK, TYR 6.789
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCHE, BCL2, CBR1, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DHFR, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR2B, HTR2C, IDO1, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 6.78146
[BP] GO:0008217 None ADORA1, ADRA1A, AR, CNR1, DRD2, DRD3, HSD11B2, PPARA, PTGS1, PTGS2, SMAD3 6.77081
[BP] GO:2000147 positive regulation of cell motility ADRA2A, APP, BCL2, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 6.70471
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA1A, ADRA2A, ALOX15, APP, AR, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, ESRRB, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, TEK, XDH 6.63195
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, BCHE, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DHFR, DRD1, DRD2, DRD3, EGFR, HSPA1A, IDO1 6.62909
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRA1A, ADRA2A, APP, AR, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, CYP1B1, CYP2D6, DHFR, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F3, FABP4, FLT3, GPR35, GSK3B, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH 6.62178
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, PTGS1, PTGS2 6.60252
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, CNR1, DRD1, DRD2, EGFR, HTR1B, HTR2A, PTGS2 6.59153
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FABP3, PPARA, PTGS1, PTGS2 6.5507
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, APP, AR, CYP1A1, CYP1B1, DRD1, EGFR, ESR1, FLT3, NR3C1, PTGS2, RORC, SLC6A4, SRC 6.54394
[BP] GO:0051272 positive regulation of cellular component movement ADRA2A, APP, BCL2, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 6.54367
[BP] GO:0009892 negative regulation of metabolic process ADORA1, ADRA2A, APEX1, APP, AR, AURKB, BCL2, CNR1, CNR2, CSNK2A1, CYP2D6, DHFR, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, GSK3B, HSPA1A, HTR1B, HTR1E, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, XDH 6.5149
[BP] GO:0007610 None APP, BCHE, BCL2, CNR1, DRD1, DRD2, DRD3, EGFR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, IDO1, INSR, PPARA, PTGS2, SLC6A4 6.49735
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AR, AXL, CDK6, CYP1B1, DRD1, EGFR, ESR1, GSK3B, IGF1R, INSR, MMP2, MMP9, NR3C1, PIK3CA, PTGS2, RORC, SLC6A4, SRC 6.48867
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, APP, BCL2, CES1, CYP19A1, CYP1A1, CYP1B1, DHFR, DRD1, DRD2, DRD3, GBA2, HTR1A, TYR 6.48423
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCHE, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CES1, CES2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DHFR, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPR35, GSK3B, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IDO1, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SIGMAR1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 6.46899
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FABP3, GBA2, GLO1, IDO1, PPARA, PTGS1, PTGS2 6.44977
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, ADRA2A, CNR1, CYP1A1, DRD3, FABP3, FLT3, HTR2A, HTR2B, HTR2C, PPARA, PTGS2, RORC, SRC, TEK 6.36955
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, DRD1, DRD2, DRD3, HTR2A, HTR2B, HTR2C, KDR, SRC 6.36205
[BP] GO:0040017 positive regulation of locomotion ADRA2A, APP, BCL2, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 6.33904
[BP] GO:0023052 None ADORA1, ADRA1A, AR, CNR1, DRD1, DRD2, DRD3, ESR2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, KCNH2, PGR, SLC6A2, TEK 6.31391
[BP] GO:0007267 None ADORA1, ADRA1A, AR, CNR1, DRD1, DRD2, DRD3, ESR2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PGR, SLC6A2, TEK 6.30915
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT 6.30763
[BP] GO:0009755 hormone-mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, RORC, SRC 6.30748
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA1A, ADRA2A, APP, AR, AXL, BCL2, CA2, CDK6, CNR1, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, ESRRB, F3, GPR35, GSK3B, HSPA1A, HTR2A, HTR2B, HTR2C, IDO1, INSR, KCNH2, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS2, XDH 6.30278
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, EGFR, FLT3, GSK3B, HTR2B, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIM1, SRC, TEK, TNKS 6.27953
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA1A, ADRA2A, ALOX15, APP, AR, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 6.25876
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, ALPL, APP, AR, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DRD1, DRD2, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FLT3, GBA2, GSK3B, HSD11B1, HSD17B2, HTR5A, INSR, KDR, MMP9, PGR, PIK3CA, PIM1, PPARA, PTGS2, RORC, SIGMAR1, SMAD3, SRC, TEK, TYR 6.2345
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, SRC, TEK 6.19607
[BP] GO:0007154 None ADORA1, ADRA1A, AR, AXL, BCL2, CNR1, DRD1, DRD2, DRD3, ESR2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PGR, PTGS2, SLC6A2, TEK 6.17309
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT 6.17309
[BP] GO:0048545 response to steroid hormone ALPL, AR, BCHE, BCL2, CA2, EGFR, FLT3, HSD11B2, HTR1B, NR3C1, PTGS2, SRC 6.14879
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, PGR, PIM1, PPARA, RORC, SRC 6.12299
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, ALOX15, APEX1, APP, AR, AURKB, BCL2, CA9, CDC25B, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DHFR, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GSK3B, HSPA1A, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 6.09703
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, PTGS1, PTGS2 6.08567
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ADRA1A, ALOX15, APP, DRD2, DUSP3, EGFR, HTR2A, HTR2B, HTR2C, KDR, PTPN1, SRC, TEK 6.05238
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, CNR1, DRD1, DRD2, DRD3, EGFR, PIK3CB, PTGS2, TNKS, TNKS2 6.00925
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA1A, ADRA2A, ALOX15, APP, AR, BCL2, CDC25B, CSNK2A1, DRD2, EGFR, ESR1, F3, FLT3, GSK3B, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.98775
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRA1A, ADRA2A, ALOX15, APP, AR, BCL2, CDC25B, DRD2, EGFR, ESR1, F3, FLT3, GSK3B, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.92307
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CDK6, CYP1B1, DRD1, EGFR, HTR1B, KCNH2, KDR, NR3C1, PTGS2, SRC 5.91447
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DHFR, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR2B, HTR2C, IDO1, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 5.91187
[BP] GO:0050801 ion homeostasis ADRA1A, APP, BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, EGFR, ESR1, FABP3, GPR35, HTR2A, HTR2B, HTR2C, KCNH2, PIK3CB, SMAD3 5.89939
[BP] GO:0006939 None ADRA1A, DRD1, DRD2, HTR1D, HTR2A, HTR2B, HTR7 5.88684
[BP] GO:0032845 None ADORA1, ADRA2A, BCL2, DRD2, HTR2A, HTR2B, HTR2C, SRC, TNKS, TNKS2 5.86208
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRA2A, APP, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, CYP2D6, DRD2, DRD3, DUSP3, ESR1, FABP4, GPR35, GSK3B, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS 5.86121
[BP] GO:0044093 positive regulation of molecular function ADORA1, ADRA1A, ADRA2A, APP, AR, AURKB, BCL2, CDC25B, DHFR, DRD2, EGFR, ESR1, ESR2, F3, FLT3, GSK3B, HSPA1A, HTR2A, HTR2B, INSR, MET, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH 5.86121
[BP] GO:0051952 None ADORA1, ADRA2A, CNR1, DRD1, DRD2, DRD3, HTR1B, HTR2A 5.80497
[BP] GO:0043269 regulation of ion transport ADORA1, ADRA2A, APP, BCL2, CA2, CA7, CNR1, DRD1, DRD2, DRD3, GPR35, HTR1A, HTR1B, HTR2A, KCNH2, MMP9, PTGS2, SLC6A4 5.78172
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT 5.77269
[BP] GO:0071495 cellular response to endogenous stimulus ADRA2A, AKR1B1, APEX1, APP, AR, DRD1, EGFR, ESR1, FLT3, GSK3B, HTR1B, IGF1R, INSR, MMP2, NR3C1, PTGS2, SLC6A4, SMAD3, SRC 5.77269
[BP] GO:0048513 animal organ development ACHE, ADRA1A, AR, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, INSR, KDR, PIK3CA, PPARA, SMAD3, SRC, TEK, TYR 5.72762
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, GSK3B, IGF1R, INSR, KDR, PIM1, SRC, TEK 5.6581
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, F3, INSR, MET, PIK3CA, PIK3CB, SRC, TEK 5.6581
[BP] GO:0099536 None CNR1, DRD1, DRD2, DRD3, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, SLC6A2 5.64807
[BP] GO:0099537 None CNR1, DRD1, DRD2, DRD3, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, SLC6A2 5.64807
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ADRA1A, ALOX15, APP, DRD2, EGFR, HTR2A, HTR2B, HTR2C, KDR, SRC, TEK 5.64473
[BP] GO:0031960 response to corticosteroid ALPL, BCHE, BCL2, EGFR, FLT3, HSD11B2, HTR1B, NR3C1, PTGS2, SRC 5.58728
[BP] GO:0032225 None DRD1, DRD2, DRD3, PTGS2, SLC6A4 5.5774
[BP] GO:0009891 positive regulation of biosynthetic process APP, AR, AURKB, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP12, NR3C1, PGR, PPARA, PTGS2, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A 5.52882
[BP] GO:0090066 None ADORA1, ADRA1A, ADRA2A, ALOX15, DRD1, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SLC6A4 5.47239
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, RORC 5.46593
[BP] GO:0098771 inorganic ion homeostasis ADRA1A, APP, BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, EGFR, ESR1, GPR35, HTR2A, HTR2B, HTR2C, KCNH2, PIK3CB, SMAD3 5.45672
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, ADRA2A, APP, AXL, BCL2, CA2, CYP19A1, DRD1, DRD2, DRD3, EGFR, GSK3B, HTR2B, INSR, KCNH2, MMP12, PTGS2, SLC6A4, SMAD3, SRC, TERT 5.44913
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRA1A, ADRA2A, APP, AURKB, BCL2, CDC25B, DHFR, DRD2, EGFR, ESR1, F3, FLT3, GSK3B, HSPA1A, HTR2A, HTR2B, INSR, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH 5.44624
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, ADRA1A, APP, CA2, CA7, DRD1, DRD2, EGFR, PTGS2 5.43043
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, DHFR, DRD1, DRD2, EGFR, GSK3B, HSD11B2, HSPA1A, HTR1A, HTR2C, IDO1, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A 5.38639
[BP] GO:0007200 None ADRA1A, ADRA2A, DRD1, DRD2, ESR1, HTR2A, HTR2B, HTR2C 5.38587
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, PPARA, PTGS2, SRC, TEK 5.37417
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA1A, ADRA2A, APP, AR, AXL, BCL2, CA2, CNR1, CYP1B1, DRD2, DRD3, EGFR, ESRRB, F3, HSPA1A, HTR2A, HTR2B, IDO1, KDR, MET, MMP12, MMP9, PIM1, PTGS2, SMAD3, SRC, TEK, TERT 5.36652
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, EGFR, FLT3, GSK3B, HTR2B, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TNKS 5.36596
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, ALOX15, APEX1, APP, AR, AURKB, BCL2, CA9, CDC25B, CNR1, CSNK2A1, CYP1B1, CYP2D6, DHFR, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GSK3B, HSPA1A, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 5.33015
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, APP, AR, AURKB, AXL, BCHE, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, DHFR, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, GBA2, GLO1, GSK3B, HSPA1A, HTR1A, HTR2B, HTR2C, IDO1, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH 5.28488
[BP] GO:0031324 negative regulation of cellular metabolic process ADRA2A, APEX1, APP, AR, AURKB, BCL2, CNR1, CSNK2A1, CYP2D6, DHFR, DRD2, DRD3, DUSP3, ESR1, ESR2, ESRRA, FABP4, GSK3B, HSPA1A, HTR1B, HTR1E, HTR2B, IGF1R, MET, MMP12, MMP9, NR3C1, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, XDH 5.2351
[BP] GO:0050890 None ADORA1, APP, BCHE, CNR1, DRD1, DRD2, DRD3, EGFR, HTR2A, INSR, PTGS2, SLC6A4 5.20314
[BP] GO:0031399 regulation of protein modification process ADORA1, ADRA1A, ADRA2A, ALOX15, APP, AR, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 5.19822
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AR, AURKB, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, MET, MMP12, NR3C1, PGR, PPARA, PTGS2, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A 5.15128
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRA1A, ADRA2A, ALOX15, APEX1, APP, AR, AURKB, BCL2, CA9, CDC25B, CNR1, CSNK2A1, CYP1A1, CYP1B1, DHFR, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GSK3B, HSPA1A, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 5.11884
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, DHFR, DRD2, EGFR, PPARA, SMAD3 5.04156
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA1A, ADRA2A, ALOX15, APP, AR, BCL2, CDC25B, DRD2, EGFR, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 5.00176
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DHFR, FABP3, GBA2, GLO1, IDO1, PIM1, PPARA, PTGS1, PTGS2, TYR 4.96235
[BP] GO:0007611 None APP, BCHE, CNR1, DRD1, DRD2, DRD3, EGFR, HTR2A, INSR, PTGS2, SLC6A4 4.91963
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.91824
[BP] GO:0071073 None FABP3, HTR2A, HTR2B, HTR2C 4.91444
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, ADRA1A, APP, AR, BCHE, BCL2, CDK6, CYP1B1, DRD2, FABP3, HSPA1A, IDO1, PTGS2, SLC6A4, SMAD3, TERT, XDH 4.91444
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CNR1, CNR2, CYP19A1, DRD1, DRD2, DRD3, EGFR, ESR1, F3, FABP4, IDO1, KDR, MET, MMP12, PPARA, PTGS2, SMAD3, TEK 4.91204
[BP] GO:0007268 None DRD1, DRD2, DRD3, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, SLC6A2 4.89715
[BP] GO:0098916 None DRD1, DRD2, DRD3, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, SLC6A2 4.89715
[BP] GO:0055080 cation homeostasis ADRA1A, APP, BCL2, CA2, CA7, DRD1, DRD2, DRD3, EGFR, ESR1, GPR35, HTR2A, HTR2B, HTR2C, KCNH2, PIK3CB, SMAD3 4.89662
[BP] GO:0072507 divalent inorganic cation homeostasis ADRA1A, APP, BCL2, DRD1, DRD2, DRD3, EGFR, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3 4.87144
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, FABP3, PPARA 4.87144
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, CDK6, GSK3B, KDR, PIK3CB, SMAD3, SRC, TEK 4.86095
[BP] GO:0051051 negative regulation of transport ADORA1, ADRA2A, APP, BCL2, CNR1, DRD2, DRD3, GPR35, GSK3B, HSPA1A, HTR1B, HTR2A, KCNH2, MMP9, PTGS2 4.76313
[BP] GO:0050999 None CNR1, CNR2, DHFR, EGFR, HTR2B, TERT 4.75702
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, SRC, TEK 4.75291
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ADRA1A, ADRA2A, ALOX15, APEX1, APP, AR, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DHFR, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GSK3B, HSPA1A, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 4.72752
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 4.72277
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, ALOX15, APEX1, APP, AR, AURKB, AXL, BCHE, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DHFR, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, GPR35, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IDO1, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SIGMAR1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 4.71437
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AR, AXL, BCL2, CDC25B, CNR1, CYP19A1, CYP1A1, DRD1, EGFR, ESR1, ESRRB, HSD11B2, HSD17B2, IDO1, INSR, MMP2, MMP9, PGR, PTGS2, SLC6A4, SRC, TOP2A 4.71437
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AR, AURKB, AXL, BCL2, CNR1, DRD2, DRD3, ESR1, GSK3B, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 4.6736
[BP] GO:0045787 positive regulation of cell cycle APEX1, APP, AURKB, CDC25B, CYP1A1, DRD2, DRD3, DUSP3, EGFR, INSR, SLC6A4, SRC, TERT 4.66419
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CYP1A1, DRD3, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TERT, TNKS, TOP2A 4.63518
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, HTR1B, MMP2, MMP9, PTGS2, TERT 4.60955
[BP] GO:0050433 None ADRA2A, CNR1, DRD2, DRD3, HTR1B, HTR2A 4.60409
[BP] GO:0009894 regulation of catabolic process ADORA1, ADRA2A, APEX1, BCL2, CNR1, CSNK2A1, EGFR, ESRRB, GSK3B, HSPA1A, HTR2A, HTR2B, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PTPN1, SMAD3 4.57921
[BP] GO:0006352 DNA-templated transcription, initiation AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, RORC 4.55617
[BP] GO:0002031 None DRD2, DRD3, HTR1B, HTR2B 4.55271
[BP] GO:0006874 cellular calcium ion homeostasis ADRA1A, APP, BCL2, DRD1, DRD2, DRD3, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3 4.54702
[BP] GO:0018958 None AKR1B1, BCL2, DRD1, DRD2, DRD3, HTR1A, TYR 4.54573
[BP] GO:0010038 response to metal ion ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, DRD2, EGFR, FABP4, MMP9, PTGS2, TERT 4.53814
[BP] GO:0051338 regulation of transferase activity ADORA1, ADRA2A, APP, AURKB, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, GSK3B, HTR2A, HTR2B, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK, TNKS 4.50786
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AR, AURKB, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, HTR2A, IGF1R, INSR, MET, MMP12, NR3C1, PGR, PPARA, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A 4.42722
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, ALOX15, APEX1, APP, AR, AURKB, AXL, BCHE, BCL2, CA1, CA2, CA7, CA9, CDC25B, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2D6, DHFR, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, GPR35, GSK3B, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IDO1, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SIGMAR1, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 4.42271
[BP] GO:0055074 calcium ion homeostasis ADRA1A, APP, BCL2, DRD1, DRD2, DRD3, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3 4.40685
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, DRD1, EGFR, GSK3B, HTR1B, IGF1R, INSR, MMP2, PTGS2, SLC6A4, SRC 4.38349
[BP] GO:0014059 None CNR1, DRD2, DRD3, HTR1B, HTR2A 4.377
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AR, AXL, BCHE, BCL2, CBR1, CDC25B, CDK6, CES1, CYP1A1, DRD1, DRD2, EGFR, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, GSK3B, HTR2B, KDR, MET, MMP2, MMP9, PGR, PTGS2, RORC, SMAD3, SRC, TEK, TERT, TOP2A 4.35907
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DHFR, FABP3, GBA2, GLO1, IDO1, PIM1, PPARA, PTGS1, PTGS2, TYR 4.35471
[BP] GO:0072503 cellular divalent inorganic cation homeostasis ADRA1A, APP, BCL2, DRD1, DRD2, DRD3, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3 4.35247
[BP] GO:0055065 metal ion homeostasis ADRA1A, APP, BCL2, DRD1, DRD2, DRD3, EGFR, ESR1, GPR35, HTR2A, HTR2B, HTR2C, KCNH2, PIK3CB, SMAD3 4.29957
[BP] GO:0033555 multicellular organismal response to stress BCL2, DRD1, HTR1A, HTR2C, IDO1, SLC6A2 4.27125
[BP] GO:0031347 regulation of defense response ADORA1, CNR1, CNR2, CYP19A1, DRD2, EGFR, ESR1, FABP4, HSPA1A, IDO1, MMP12, MMP2, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 4.26905
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, ADRA2A, DUSP3, EGFR, FLT3, HTR2A, HTR2B, IGF1R, INSR, PIK3CB, PTPN1, SRC 4.26657
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DHFR, FABP3, GBA2, GLO1, IDO1, PIM1, PPARA, PTGS1, PTGS2, TYR 4.24482
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.24466
[BP] GO:0035265 organ growth ADRA1A, AR, BCL2, CYP19A1, ESR1 4.23629
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, PTGS1, PTGS2, SRC 4.23629
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, CYP2D6, GSK3B, MET, MMP9, PPARA, SMAD3, SRC, TERT, TNKS 4.23629
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CES1, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 4.23629
[BP] GO:0032768 None CNR1, CNR2, DHFR, EGFR, HTR2B, TERT 4.23629
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, ALOX15, APEX1, APP, AR, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A2, CYP1B1, DHFR, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, GLO1, GSK3B, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 4.23146
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ADRA1A, ADRA2A, ALOX15, APP, AR, BCL2, CDC25B, CSNK2A1, DHFR, DRD1, DRD2, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GSK3B, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.19881
[BP] GO:2001023 None CNR1, DRD1, DRD2, DRD3, HTR1B, HTR2A, MET 4.19247
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 4.17457
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, GSK3B, HSD11B2, IGF1R, INSR, PPARA, PTGS2, SRC, TEK 4.16594
[BP] GO:0051588 None DRD1, DRD2, DRD3, HTR1A, HTR1B, HTR2C, SLC6A4 4.16458
[BP] GO:0051726 regulation of cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, DRD2, DRD3, DUSP3, EGFR, HSPA1A, INSR, PIM1, PTGS2, SLC6A4, SMAD3, SRC, TERT, TNKS, TOP2A 4.16458
[BP] GO:0050793 regulation of developmental process APP, AR, AXL, BCL2, CA2, CDK6, CNR1, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, ESRRB, F3, GSK3B, HTR2A, HTR2C, IDO1, INSR, KDR, NUAK1, PIK3CA, PIM1, PPARA, PTGS2, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS2, XDH 4.14723
[BP] GO:0051967 None ADORA1, DRD2, HTR1B, HTR2A 4.12993
[BP] GO:0030003 cellular cation homeostasis ADRA1A, APP, BCL2, CA2, CA7, DRD1, DRD2, DRD3, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3 4.11775
[BP] GO:1900542 None ADRA2A, DRD1, DRD2, DRD3, ESRRB, HTR1B, HTR1E, HTR2A, INSR, PPARA 4.09259
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, BCHE, CSNK2A1, DRD1, DRD2, DRD3, HTR1A 4.07255
[BP] GO:0009968 negative regulation of signal transduction ADRA1A, ADRA2A, AR, BCL2, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, GSK3B, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SMAD3, SRC, TERT, XDH 4.0668
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC, TEK 4.05419
[BP] GO:0055082 cellular chemical homeostasis ADRA1A, APP, BCL2, CA2, CA7, DRD1, DRD2, DRD3, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB, SMAD3 4.05419
[BP] GO:0010863 positive regulation of phospholipase C activity ADRA1A, EGFR, ESR1, HTR2A, HTR2B 4.05419
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, APP, DRD1, EGFR, GSK3B, HTR1B, IGF1R, INSR, MMP2, PTGS2, SLC6A4, SRC 4.04622
[BP] GO:0007623 circadian rhythm DRD2, DRD3, EGFR, GSK3B, HTR7, PPARA, RORC, SLC6A4 4.04214
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.00489
[BP] GO:0006873 cellular ion homeostasis ADRA1A, APP, BCL2, CA2, CA7, DRD1, DRD2, DRD3, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3 4.00394
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.00227
[BP] GO:0006140 None ADRA2A, DRD1, DRD2, DRD3, ESRRB, HTR1B, HTR1E, HTR2A, INSR, PPARA 3.99438
[BP] GO:0051384 response to glucocorticoid ALPL, BCHE, BCL2, EGFR, FLT3, HSD11B2, NR3C1, PTGS2 3.9786
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, BCL2, CDK6, GSK3B, KDR, PIK3CB, SMAD3, SRC, TEK 3.97299
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 3.95522
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, EGFR, HTR6 3.9368
[BP] GO:0071071 None FABP3, HTR2A, HTR2B, HTR2C 3.90479
[BP] GO:0010513 None HTR2A, HTR2B, HTR2C 3.90216
[BP] GO:1902532 negative regulation of intracellular signal transduction ADRA1A, BCL2, DRD2, DRD3, DUSP3, ESR1, HSPA1A, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 3.89534
[BP] GO:1900274 regulation of phospholipase C activity ADRA1A, EGFR, ESR1, HTR2A, HTR2B 3.88036
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, APP, CDC25B, CYP1A1, DRD3, DUSP3, INSR, TERT 3.87576
[BP] GO:0035556 intracellular signal transduction ADRA1A, ADRA2A, AKR1B1, AXL, BCL2, CYP1B1, DRD1, DRD2, DRD3, EGFR, GSK3B, HTR2A, HTR2B, HTR5A, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PTPN1, SRC, TEK 3.87576
[BP] GO:0043549 regulation of kinase activity ADORA1, ADRA2A, APP, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK 3.86516
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, ADRA2A, CNR1, CYP19A1, DRD2, DRD3, EGFR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MMP12, SLC6A4, SRC 3.83683
[BP] GO:0009410 None CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, HTR1B, NR3C1 3.83502
[BP] GO:0051347 positive regulation of transferase activity ADORA1, ADRA2A, AURKB, CDC25B, DRD2, EGFR, FLT3, HTR2A, HTR2B, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK, TNKS 3.81486
[BP] GO:0040014 regulation of multicellular organism growth APP, BCL2, DRD2, DRD3, PIK3CA, TNKS2 3.78322
[BP] GO:0007613 None CNR1, DRD1, DRD2, HTR2A, INSR, PTGS2, SLC6A4 3.76149
[BP] GO:0050727 regulation of inflammatory response ADORA1, CNR1, CNR2, CYP19A1, EGFR, ESR1, FABP4, IDO1, PPARA, PTGS2, SMAD3, TEK 3.7409
[BP] GO:0001101 response to acid chemical AKR1B1, BCHE, DHFR, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGS2, SLC6A4, SRC 3.72971
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, BCL2, DRD3, GSK3B, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 3.72151
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, EGFR 3.71282
[BP] GO:0014821 None DRD1, DRD2, HTR1D, HTR2B 3.70611
[BP] GO:0019725 cellular homeostasis ADRA1A, APEX1, APP, BCL2, CA2, CA7, DRD1, DRD2, DRD3, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB, SMAD3 3.69861
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, GSK3B, MET, MMP9, PPARA, SRC, TERT 3.69376
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 3.69314
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 3.69314
[BP] GO:0009895 negative regulation of catabolic process ADORA1, ADRA2A, BCL2, CNR1, EGFR, HTR2B, MET, PIK3CA, PPARA, SMAD3 3.69242
[BP] GO:0045859 regulation of protein kinase activity ADORA1, ADRA2A, APP, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC 3.68385
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, ADRA2A, EGFR, FLT3, HTR2A, HTR2B, INSR, PIK3CB, PTPN1, SRC 3.68137
[BP] GO:0003012 None ADORA1, ADRA1A, DRD1, DRD2, HTR1D, HTR2A, HTR2B, HTR7, KCNH2, PIK3CA 3.68137
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, FABP3, PPARA 3.66199
[BP] GO:1900543 None ADRA2A, DRD2, DRD3, HTR1B, HTR1E, PPARA 3.6566
[BP] GO:0050678 None AR, CDK6, EGFR, F3, HTR2B, KDR, MMP12, PGR, SMAD3, TEK, XDH 3.64701
[BP] GO:0032229 None ADORA1, CNR2, HTR1B 3.64132
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2C19, CYP2D6 3.64132
[BP] GO:0033674 positive regulation of kinase activity ADORA1, ADRA2A, CDC25B, DRD2, EGFR, FLT3, HTR2A, HTR2B, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK 3.64048
[BP] GO:0045980 None ADRA2A, DRD2, DRD3, HTR1B, HTR1E, PPARA 3.62679
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, HTR2A, INSR, MET, SMAD3, SRC 3.61214
[BP] GO:0045776 None ADORA1, CNR1, DRD2, DRD3, PPARA 3.57952
[BP] GO:0006936 None ADRA1A, DRD1, DRD2, HTR1D, HTR2A, HTR2B, HTR7, KCNH2, PIK3CA 3.56181
[BP] GO:0050789 regulation of biological process ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, ALOX15, APEX1, APP, AR, AURKB, AXL, BCHE, BCL2, CA1, CA2, CA7, CA9, CDC25B, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DHFR, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, GPR35, GSK3B, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IDO1, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SIGMAR1, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 3.55563
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, EGFR, MMP2, MMP9, TEK 3.55563
[BP] GO:0048148 None DRD1, DRD2, DRD3, HTR2A 3.53833
[BP] GO:0090087 None ACHE, ADORA1, ADRA2A, APP, CA2, CNR1, DRD2, DRD3, EGFR, GSK3B, HTR2B, HTR2C, MMP12, PTGS2, PTPN1, SMAD3, SRC 3.53833
[BP] GO:0006875 cellular metal ion homeostasis ADRA1A, APP, BCL2, DRD1, DRD2, DRD3, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3 3.51956
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FABP3, FABP4, FUT7, GBA2, GSK3B, HSPA1A, IDO1, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH 3.50331
[BP] GO:0051046 None ACHE, ADORA1, ADRA2A, CNR1, CYP19A1, DRD2, DRD3, EGFR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MMP12, SLC6A4, SRC 3.47647
[BP] GO:0006811 None ADRA1A, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, DRD3, FABP3, HTR2A, HTR2B, HTR2C, KCNH2, PPARA, SLC6A2, SLC6A4 3.47445
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, HTR2A, MET, PIK3CA 3.4655
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 3.45607
[BP] GO:0040008 regulation of growth APP, AR, BCL2, CSNK2A1, DRD2, DRD3, EGFR, ESR2, HSPA1A, INSR, PIK3CA, PIM1, SLC6A4, SMAD3, TNKS2 3.44843
[BP] GO:0001954 positive regulation of cell-matrix adhesion CDK6, GSK3B, KDR, SMAD3, TEK 3.4467
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway AR, ESR1, ESR2, NR3C1, PGR, SRC 3.44513
[BP] GO:0008283 cell proliferation ACHE, AR, AURKB, BCL2, CYP1A1, EGFR, ESR1, FLT3, HTR1A, MET, PIK3CB, PIM1, SRC, TEK, TYR 3.44513
[BP] GO:0009820 alkaloid metabolic process BCHE, CYP1A2, CYP2D6 3.42876
[BP] GO:0014062 None HTR1A, HTR1B, SLC6A4 3.42876
[BP] GO:0010511 None HTR2A, HTR2B, HTR2C 3.42876
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, DHFR, EGFR, INSR, PTGS2, SMAD3, XDH 3.4224
[BP] GO:0016477 cell migration AXL, CNR2, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR2B, HTR6, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC, TEK 3.39797
[BP] GO:0031348 negative regulation of defense response ADORA1, CNR2, CYP19A1, DRD2, MMP12, PPARA, SMAD3, TEK 3.38706
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation HTR1B, MMP2, MMP9, TERT 3.38538
[BP] GO:0051246 regulation of protein metabolic process ADORA1, ADRA1A, ADRA2A, ALOX15, APP, AR, BCL2, CDC25B, CSNK2A1, DHFR, DRD1, DRD2, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GSK3B, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.37342
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.36409
[BP] GO:0032355 response to estradiol CYP1A2, EGFR, ESR1, ESRRA, HTR5A, PTGS2, SLC6A4 3.34225
[BP] GO:0030155 regulation of cell adhesion ALOX15, BCL2, CDK6, CYP1B1, DUSP3, GSK3B, IDO1, KDR, NUAK1, PIK3CA, PIK3CB, PPARA, SMAD3, SRC, TEK 3.33977
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC 3.33821
[BP] GO:0033273 response to vitamin ALPL, BCHE, CYP1A1, EGFR, PTGS2, TYR 3.33411
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCHE, BCL2, CNR1, CYP1A1, EGFR, HSD11B2, PTGS2, SLC6A4, SRC, TYR 3.33018
[BP] GO:0007568 aging ADRA1A, APEX1, AURKB, BCL2, CNR1, CYP1A1, HTR2A, PTGS2, TERT 3.32917
[BP] GO:0030815 None ADRA2A, DRD2, DRD3, HTR1B, HTR1E 3.32686
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, EGFR 3.32686
[BP] GO:0051953 None ADORA1, ADRA2A, CNR1, DRD2 3.31733
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AR, AURKB, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, IGF1R, INSR, KDR, MET, MMP12, NR3C1, PGR, PPARA, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A 3.31314
[BP] GO:1904063 None ADRA2A, DRD2, DRD3, GPR35, KCNH2, MMP9 3.31314
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK 3.31314
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CES1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.31049
[BP] GO:0010518 positive regulation of phospholipase activity ADRA1A, EGFR, ESR1, HTR2A, HTR2B 3.28968
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, ADRA2A, CDC25B, DRD2, EGFR, FLT3, HTR2A, HTR2B, INSR, PIK3CA, PIK3CB, PTPN1, SRC 3.28847
[BP] GO:0019932 second-messenger-mediated signaling ADRA1A, ADRA2A, DRD1, DRD2, DRD3, EGFR, HTR2B, HTR5A, KDR 3.28098
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, HTR1B, MMP2, MMP9, PTGS2, TERT 3.2698
[BP] GO:0051940 None DRD1, DRD2, DRD3 3.25542
[BP] GO:0051584 None DRD1, DRD2, DRD3 3.25542
[BP] GO:0030800 None ADRA2A, DRD2, DRD3, HTR1B, HTR1E 3.25476
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.25476
[BP] GO:0007202 None ADRA1A, EGFR, HTR2A, HTR2B 3.25476
[BP] GO:0003006 developmental process involved in reproduction ALPL, AR, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, INSR, PGR, PTGS2, SRC 3.25411
[BP] GO:0044057 None ADORA1, ADORA3, ADRA1A, ADRA2A, DRD2, DRD3, EGFR, GPR35, HTR2A, HTR2C, KCNH2, PTGS2, SMAD3 3.25411
[BP] GO:0008150 biological_process ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCHE, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CES1, CES2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DHFR, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPR35, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IDO1, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SIGMAR1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 3.2448
[BP] GO:0051094 positive regulation of developmental process APP, AR, AXL, BCL2, CA2, CNR1, CYP1B1, DRD2, ESRRB, F3, HTR2A, HTR2C, IDO1, INSR, KDR, PIM1, PTGS2, SMAD3, SRC, TEK, TERT 3.19438
[BP] GO:0048732 gland development AR, BCL2, CSNK2A1, CYP19A1, EGFR, INSR, PIK3CA, SMAD3, TYR 3.19242
[BP] GO:0042133 neurotransmitter metabolic process ACHE, BCHE, CYP1B1, DHFR, HTR1A, SLC6A4 3.18602
[BP] GO:0051341 None CNR1, CNR2, DHFR, EGFR, HTR2B, TERT 3.18602
[BP] GO:0031329 regulation of cellular catabolic process ADRA2A, APEX1, BCL2, CNR1, ESRRB, GSK3B, HSPA1A, HTR2A, HTR2B, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PTPN1 3.17442
[BP] GO:0051172 None ADRA2A, APEX1, APP, AR, AURKB, CSNK2A1, DHFR, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, HSPA1A, HTR1B, HTR1E, IGF1R, MMP12, MMP9, NR3C1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, XDH 3.16992
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DRD1, EGFR, F10, FLT3, GSK3B, IGF1R, INSR, KDR, MET, SRC, TEK, TNKS, TOP2A 3.15583
[BP] GO:0048638 regulation of developmental growth APP, AR, BCL2, DRD2, DRD3, INSR, PIK3CA, PIM1, SLC6A4, TNKS2 3.13691
[BP] GO:0001975 None CNR2, DRD1, DRD2, DRD3 3.12558
[BP] GO:0007612 None APP, BCHE, DRD1, DRD2, DRD3, INSR, PTGS2 3.1202
[BP] GO:0019933 None ADRA1A, ADRA2A, DRD1, DRD2, DRD3, HTR5A 3.11129
[BP] GO:0010628 positive regulation of gene expression APP, AR, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, GSK3B, HSPA1A, INSR, MET, MMP12, NR3C1, PGR, PIK3CB, PPARA, RORC, SLC6A4, SMAD3, SRC, TERT, TNKS, TOP2A 3.08938
[BP] GO:0031623 None ACHE, DRD2, DRD3, HTR1B, HTR2B 3.07017
[BP] GO:0007584 response to nutrient ALPL, BCHE, CNR1, CYP1A1, EGFR, PTGS2, SLC6A4, TYR 3.05614
[BP] GO:0009605 response to external stimulus ADORA1, ADRA1A, ALPL, AXL, BCHE, BCL2, CDK6, CNR1, CNR2, CYP1A1, CYP1A2, DRD3, EGFR, HSD11B2, HTR2A, IDO1, MMP12, PTGS2, SLC6A4, SMAD3, SRC, TYR 3.04871
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.04189
[BP] GO:0034766 None ADRA2A, DRD2, DRD3, GPR35, KCNH2, MMP9 3.03938
[BP] GO:0010564 regulation of cell cycle process APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, DRD2, DRD3, EGFR, HSPA1A, INSR, TERT, TNKS 3.02171
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC 3.01519
[BP] GO:0048609 multicellular organismal reproductive process AKR1B1, APP, AR, AXL, CNR1, CYP1A1, DRD1, EGFR, ESR1, PGR, PTGS2, SLC6A4, SRC 3.01519
[BP] GO:0010906 None ESRRB, GSK3B, INSR, PPARA, RORC, SRC 2.99195
[BP] GO:0003014 None ADORA1, ADRA1A, AKR1B1, BCL2, DRD2, HSD11B2 2.99195
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, APP, AXL, BCL2, CA2, CDK6, CNR1, CNR2, CYP19A1, DRD2, DUSP3, ESR1, ESRRA, HSPA1A, IDO1, MMP12, MMP2, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC 2.96463
[BP] GO:0042391 None ADORA1, ADRA1A, APP, BCL2, CNR1, CNR2, DRD1, GPR35, KCNH2, KDR, SRC 2.95885
[BP] GO:0043266 None ADORA1, ADRA2A, DRD1, DRD2, HTR2A, KCNH2 2.94566
[BP] GO:0042752 None ADORA1, DRD2, DRD3, PPARA, RORC, TOP2A 2.94566
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TERT, TNKS, TNKS2 2.93838
[BP] GO:0010517 regulation of phospholipase activity ADRA1A, EGFR, ESR1, HTR2A, HTR2B 2.93838
[BP] GO:0046883 regulation of hormone secretion ADORA1, ADRA2A, CNR1, CYP19A1, DRD2, EGFR, HTR1A, HTR2A, HTR2C 2.93838
[BP] GO:0048870 cell motility AXL, CNR2, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR2B, HTR6, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC, TEK 2.93686
[BP] GO:0045934 None ADRA2A, APEX1, AR, AURKB, DRD2, DRD3, ESR1, ESR2, ESRRA, FABP4, HSPA1A, HTR1B, HTR1E, MMP12, NR3C1, PPARA, RORC, SMAD3, SRC, TERT, TNKS, TNKS2 2.92454
[BP] GO:0031667 response to nutrient levels ALPL, BCHE, BCL2, CNR1, CYP1A1, EGFR, HSD11B2, PTGS2, SLC6A4, SRC, TYR 2.91877
[BP] GO:0002683 negative regulation of immune system process ADORA1, ALOX15, AXL, CDK6, CNR1, CNR2, CYP19A1, DRD2, DUSP3, IDO1, MMP12 2.9109
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.9109
[BP] GO:0080135 regulation of cellular response to stress APP, CDK6, DHFR, DUSP3, EGFR, GSK3B, HSPA1A, IGF1R, MET, NUAK1, PTGS2, PTPN1, TERT, XDH 2.9109
[BP] GO:0019229 None ADRA1A, ADRA2A, EGFR, HTR2A, PTGS2 2.91013
[BP] GO:0019935 None ADRA1A, ADRA2A, DRD1, DRD2, DRD3, HTR5A 2.90791
[BP] GO:0034763 None ADRA2A, DRD2, DRD3, GPR35, KCNH2, MMP9 2.90791
[BP] GO:0002209 None BCL2, DRD1, HTR1A, HTR2C 2.9046
[BP] GO:0001662 None BCL2, DRD1, HTR1A, HTR2C 2.9046
[BP] GO:0040011 locomotion AXL, CNR2, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR2B, HTR6, KDR, MET, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC, TEK 2.89331
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, HTR2A, MET, SRC 2.88977
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, HTR2A, MET, SRC 2.88977
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, HTR2A, MET, SRC 2.88977
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, HTR2A, MET, SRC 2.88977
[BP] GO:0048015 phosphatidylinositol-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 2.88417
[BP] GO:0032880 regulation of protein localization ACHE, ADRA2A, APP, AR, BCL2, CNR1, CSNK2A1, DRD2, DRD3, EGFR, GSK3B, HTR2B, MMP12, PTGS2, PTPN1, SMAD3, SRC, TERT 2.87652
[BP] GO:0042220 None CNR1, DRD2, DRD3, HTR1B 2.85686
[BP] GO:0045777 None ADORA1, ADRA1A, CNR1, HSD11B2 2.85686
[BP] GO:0001659 None ADORA1, DRD1, DRD2, HTR2A 2.85686
[BP] GO:0045744 None ADRA2A, DRD2, DRD3, MET 2.85686
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 2.85686
[BP] GO:0019371 None CBR1, PTGS1, PTGS2 2.85686
[BP] GO:0060193 positive regulation of lipase activity ADRA1A, EGFR, ESR1, HTR2A, HTR2B 2.85686
[BP] GO:0090068 positive regulation of cell cycle process APEX1, APP, AURKB, CDC25B, CYP1A1, DRD2, DRD3, INSR, TERT 2.82616
[BP] GO:0007208 None HTR2A, HTR2C 2.82616
[BP] GO:0009115 None AOX1, XDH 2.82616
[BP] GO:2001234 negative regulation of apoptotic signaling pathway AR, BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC, TERT 2.82568
[BP] GO:0022029 None DRD1, DRD2, EGFR, HTR6 2.8129
[BP] GO:0042596 None BCL2, DRD1, HTR1A, HTR2C 2.8129
[BP] GO:0046889 None FABP3, HTR2A, HTR2B, HTR2C, PTGS2 2.80197
[BP] GO:0060402 None ADRA1A, DRD2, HTR2A, HTR2B, HTR2C 2.80197
[BP] GO:0048017 inositol lipid-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 2.80197
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, IDO1, PTGS2, SRC 2.79908
[BP] GO:0010811 positive regulation of cell-substrate adhesion ALOX15, CDK6, GSK3B, KDR, SMAD3, TEK 2.79313
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CNR2, CYP19A1, DRD1, DRD2, DRD3, PPARA, SMAD3, TEK 2.77734
[BP] GO:0032103 positive regulation of response to external stimulus CNR1, EGFR, F3, FABP4, IDO1, KDR, MET, PTGS2, SMAD3 2.77734
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, ADRA2A, DUSP3, EGFR, FLT3, HTR2A, HTR2B, IGF1R, INSR, PIK3CB, PTPN1, SRC 2.7767
[BP] GO:2000026 regulation of multicellular organismal development APP, AR, AXL, BCL2, CA2, CDK6, CNR1, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, F3, GSK3B, IDO1, INSR, KDR, PIM1, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 2.77638
[BP] GO:0051926 negative regulation of calcium ion transport ADRA2A, BCL2, DRD2, GPR35, PTGS2 2.7761
[BP] GO:0010907 None ESRRB, INSR, PPARA, SRC 2.76993
[BP] GO:0045907 None ADRA1A, EGFR, HTR2A, PTGS2 2.76993
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, ADRA2A, EGFR, FLT3, HTR2A, HTR2B, INSR, PIK3CB, PTPN1, SRC 2.75993
[BP] GO:0045759 None CNR1, CNR2, GPR35 2.75844
[BP] GO:0015872 None DRD1, SLC6A2, SLC6A4 2.75844
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC 2.75844
[BP] GO:0002009 morphogenesis of an epithelium AR, BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.75145
[BP] GO:0051254 None APP, AR, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, INSR, MET, MMP12, NR3C1, PGR, PPARA, RORC, SMAD3, SRC, TERT, TNKS, TOP2A 2.73743
[BP] GO:0010959 None ADORA1, ADRA2A, BCL2, DRD1, DRD2, DRD3, GPR35, HTR2A, KCNH2, PTGS2 2.72511
[BP] GO:0051480 regulation of cytosolic calcium ion concentration ADRA1A, DRD1, DRD2, ESR1, GPR35, HTR2A, HTR2B, HTR2C, SMAD3 2.72082
[BP] GO:0009416 response to light stimulus APP, AURKB, BCL2, DRD1, DRD2, DRD3, EGFR, PTGS2, TYR 2.72082
[BP] GO:1903522 None ADORA1, ADORA3, ADRA1A, ADRA2A, DRD2, EGFR, HTR2A, KCNH2, PTGS2 2.72082
[BP] GO:0071396 cellular response to lipid AR, AXL, CDK6, EGFR, ESR1, FLT3, NR3C1, RORC, SLC6A4, SRC 2.71832
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, NQO2, XDH 2.71005
[BP] GO:0045913 None ESRRB, HTR2A, INSR, PPARA, SRC 2.69536
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1, IDO1 2.66553
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.66022
[BP] GO:0060134 None DRD1, DRD2, DRD3 2.66022
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic ADRA1A, CA2, CA7 2.66022
[BP] GO:0033604 None ADRA2A, CNR1, DRD2 2.66022
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CNR1, CYP1B1, F3, GSK3B, IDO1, MMP9, PIK3CB, PTGS2, SMAD3, SRC, TOP2A, XDH 2.63926
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CNR2, CYP19A1, PPARA, SMAD3, TEK 2.62108
[BP] GO:0009896 positive regulation of catabolic process ADRA2A, CSNK2A1, ESRRB, GSK3B, HSPA1A, HTR2A, INSR, KDR, PIK3CB, PPARA, PTPN1 2.61055
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, IDO1, PTGS2, SRC 2.60696
[BP] GO:0030814 None ADRA2A, DRD1, DRD2, DRD3, HTR1B, HTR1E 2.60411
[BP] GO:0051128 regulation of cellular component organization ALOX15, APP, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, DRD2, DRD3, EGFR, ESR1, ESR2, GSK3B, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PIK3CB, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 2.60356
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CNR1, CYP1B1, F3, GSK3B, IDO1, MMP9, PIK3CB, PTGS2, SMAD3, SRC, TOP2A, XDH 2.60242
[BP] GO:0007212 None DRD1, DRD2, DRD3, GSK3B 2.59783
[BP] GO:0032467 None AURKB, CDC25B, DRD2, DRD3 2.59783
[BP] GO:0046456 icosanoid biosynthetic process ALOX15, ALOX5, PTGS1, PTGS2 2.59783
[BP] GO:0007189 None ADRA1A, ADRA2A, DRD1, DRD2, DRD3 2.5926
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 2.5926
[BP] GO:0050730 None ADORA1, ADRA2A, APP, EGFR, FLT3, HTR2A, PTPN1, SRC 2.59182
[BP] GO:0045893 None APP, AR, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, INSR, MET, MMP12, NR3C1, PGR, PPARA, RORC, SMAD3, SRC, TERT, TNKS, TOP2A 2.59182
[BP] GO:1903508 None APP, AR, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, INSR, MET, MMP12, NR3C1, PGR, PPARA, RORC, SMAD3, SRC, TERT, TNKS, TOP2A 2.59182
[BP] GO:1902680 None APP, AR, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, INSR, MET, MMP12, NR3C1, PGR, PPARA, RORC, SMAD3, SRC, TERT, TNKS, TOP2A 2.5882
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.57416
[BP] GO:0051580 None DRD1, DRD2, DRD3 2.57416
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.56873
[BP] GO:0002791 None ACHE, ADORA1, ADRA2A, CNR1, DRD2, DRD3, EGFR, HTR2B, HTR2C, MMP12, SRC 2.56427
[BP] GO:0014075 None CNR2, DRD1, DRD2, DRD3 2.56015
[BP] GO:0051241 negative regulation of multicellular organismal process ADORA1, ADRA1A, APP, AXL, BCL2, CDK6, DRD2, DRD3, EGFR, GPR35, GSK3B, IDO1, PTGS2, SLC6A4, SMAD3, TEK, TERT, XDH 2.54523
[BP] GO:0071383 None AR, EGFR, FLT3, NR3C1, SRC 2.54408
[BP] GO:0006109 regulation of carbohydrate metabolic process ESRRB, GSK3B, HTR2A, INSR, PPARA, RORC, SRC 2.54102
[BP] GO:0050679 None AR, EGFR, F3, HTR2B, KDR, MMP12, TEK 2.52615
[BP] GO:1904705 regulation of vascular smooth muscle cell proliferation HTR1B, MMP2, MMP9, TERT 2.52001
[BP] GO:0010675 None ESRRB, GSK3B, INSR, PPARA, RORC, SRC 2.52001
[BP] GO:0032413 None ADRA2A, DRD2, DRD3, GPR35, MMP9 2.52001
[BP] GO:2001233 regulation of apoptotic signaling pathway AR, BCL2, GSK3B, HSPA1A, MMP9, PTGS2, PTPN1, SMAD3, SRC, TERT 2.50464
[BP] GO:0009889 regulation of biosynthetic process ADORA3, ADRA2A, APEX1, APP, AR, AURKB, BCL2, CA9, CSNK2A1, CYP1B1, DHFR, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GSK3B, HSPA1A, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP12, NR3C1, NR3C2, PGR, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A 2.50259
[BP] GO:0043467 regulation of generation of precursor metabolites and energy ESRRB, GSK3B, HTR2A, INSR, PIK3CA, PPARA 2.50259
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, EGFR, HTR2B, MMP12, SLC6A4, SRC 2.49754
[BP] GO:0060401 None ADRA1A, DRD2, HTR2A, HTR2B, HTR2C 2.49631
[BP] GO:0001963 None DRD1, DRD2, DRD3 2.49301
[BP] GO:0051937 None DRD1, SLC6A2, SLC6A4 2.49301
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.49301
[BP] GO:1901654 None AKR1B1, AR, CA9, CSNK2A1, EGFR, NR3C1, SRC 2.48901
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC, TEK 2.44947
[BP] GO:0070201 None ACHE, ADRA2A, APP, BCL2, CNR1, DRD2, DRD3, EGFR, GSK3B, HTR2B, MMP12, PTGS2, PTPN1, SMAD3, SRC 2.44925
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, PTGS2, SMAD3 2.44403
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.44403
[BP] GO:0032147 activation of protein kinase activity ADORA1, ADRA2A, DRD2, EGFR, INSR, PIK3CA, PIK3CB, PTPN1, SRC 2.44061
[BP] GO:0060748 None AR, PGR 2.42548
[BP] GO:0046110 None AOX1, XDH 2.42548
[BP] GO:0060160 None DRD2, DRD3 2.42548
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.42548
[BP] GO:0033602 None CNR1, DRD2 2.42548
[BP] GO:0032227 negative regulation of synaptic transmission, dopaminergic PTGS2, SLC6A4 2.42548
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.42111
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.42111
[BP] GO:0070920 None EGFR, ESR1, TERT 2.42111
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.42111
[BP] GO:0043268 None ADORA1, ADRA2A, DRD1, KCNH2 2.41588
[BP] GO:0007204 positive regulation of cytosolic calcium ion concentration ADRA1A, DRD1, DRD2, ESR1, GPR35, HTR2A, HTR2B, HTR2C 2.41207
[BP] GO:0001819 positive regulation of cytokine production ADRA2A, CYP1B1, DRD2, HSPA1A, HTR2B, IDO1, MMP12, PTGS2, SMAD3, SRC 2.40032
[BP] GO:0031331 positive regulation of cellular catabolic process ADRA2A, ESRRB, GSK3B, HSPA1A, HTR2A, INSR, KDR, PIK3CB, PPARA, PTPN1 2.40032
[BP] GO:1901655 None AKR1B1, AR, EGFR, NR3C1, SRC 2.38743
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, DRD3 2.38052
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, DRD3 2.38052
[BP] GO:1900182 positive regulation of protein localization to nucleus APP, EGFR, PTGS2, SMAD3, SRC, TERT 2.37763
[BP] GO:0046683 response to organophosphorus APEX1, APP, PTGS2, SLC6A4, TEK, TYR 2.37763
[BP] GO:0031326 regulation of cellular biosynthetic process ADORA3, ADRA2A, APEX1, APP, AR, AURKB, BCL2, CA9, CSNK2A1, CYP1B1, DHFR, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GSK3B, HSPA1A, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, INSR, MET, MMP12, NR3C1, NR3C2, PGR, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A 2.36088
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, DRD2, EGFR, F3, FLT3, GPR35, GSK3B, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 2.35063
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.34877
[BP] GO:0030818 None ADRA2A, DRD2, DRD3, HTR1B 2.34683
[BP] GO:0032410 None ADRA2A, DRD2, DRD3, GPR35, MMP9 2.34506
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, DRD2, EGFR, FABP3, FABP4, MET, PIK3CA, PIK3CB 2.33043
[BP] GO:0010942 positive regulation of cell death BCL2, CNR1, CYP1B1, F3, GSK3B, IDO1, MMP9, PIK3CB, PTGS2, SMAD3, SRC, TOP2A, XDH 2.32776
[BP] GO:0051781 None AURKB, CDC25B, DRD2, DRD3, HTR2B 2.32326
[BP] GO:1901989 None APEX1, APP, CDC25B, CYP1A1, TERT 2.32326
[BP] GO:0051283 None DRD2, HTR2A, HTR2B, HTR2C 2.31402
[BP] GO:0051209 None DRD2, HTR2A, HTR2B, HTR2C 2.31402
[BP] GO:0097366 None CNR2, DRD1, DRD2, DRD3 2.31402
[BP] GO:0060191 regulation of lipase activity ADRA1A, EGFR, ESR1, HTR2A, HTR2B 2.30176
[BP] GO:0045595 regulation of cell differentiation APP, AR, AXL, BCL2, CA2, CDK6, CNR1, DRD2, DRD3, EGFR, ESRRA, ESRRB, GSK3B, HTR2A, HTR2C, KDR, PPARA, PTGS2, RORC, SLC6A4, SMAD3, TERT, XDH 2.28842
[BP] GO:0006928 movement of cell or subcellular component ADRA2A, APP, AXL, CNR2, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR2B, HTR6, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TEK 2.28838
[BP] GO:0031099 regeneration AXL, BCL2, CSNK2A1, DHFR, EGFR, FLT3 2.28414
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.28414
[BP] GO:0051000 None DHFR, HTR2B, TERT 2.28414
[BP] GO:0045821 None ESRRB, HTR2A, INSR 2.28414
[BP] GO:0042058 None ADORA1, ADRA2A, APP, EGFR, MMP9 2.28414
[BP] GO:0042136 neurotransmitter biosynthetic process ACHE, CYP1B1, DHFR, SLC6A4 2.28414
[BP] GO:0030803 None ADRA2A, DRD2, DRD3, HTR1B 2.28414
[BP] GO:0040007 None ADRA1A, APP, AR, BCL2, CYP19A1, ESR1, SMAD3, SRC, TNKS2 2.24671
[BP] GO:0060359 None CNR1, DRD1, DRD2, DRD3, HTR1B 2.23903
[BP] GO:0010605 negative regulation of macromolecule metabolic process APEX1, APP, AR, AURKB, CSNK2A1, DHFR, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, GSK3B, HSPA1A, IGF1R, KDR, MMP12, MMP9, NR3C1, PGR, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, XDH 2.23651
[BP] GO:0030534 None APP, DRD1, DRD2, DRD3, HTR2A, PPARA 2.22175
[BP] GO:0045187 None ADORA1, DRD2, DRD3 2.21893
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.21893
[BP] GO:0051197 None ESRRB, HTR2A, INSR 2.21893
[BP] GO:0006807 nitrogen compound metabolic process ACHE, AKR1B1, AKR1B10, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCHE, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DHFR, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FLT3, FUT7, GBA2, GLO1, GSK3B, HSPA1A, HTR1A, HTR2B, HTR2C, IDO1, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 2.21849
[BP] GO:0008542 None APP, DRD1, DRD2, DRD3 2.21849
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, PTGS2, SMAD3, XDH 2.19996
[BP] GO:0032870 cellular response to hormone stimulus ADRA2A, APEX1, AR, EGFR, ESR1, FLT3, INSR, NR3C1, SRC 2.19807
[BP] GO:0051336 regulation of hydrolase activity ADRA1A, APP, CSNK2A1, DRD2, EGFR, ESR1, F3, GSK3B, HSPA1A, HTR2A, HTR2B, MMP9, NUAK1, PTGS2, PTPN1, SMAD3, SRC, XDH 2.19807
[BP] GO:0030799 None ADRA2A, DRD1, DRD2, DRD3, HTR1B, HTR1E 2.19639
[BP] GO:0048608 reproductive structure development AR, AXL, BCL2, CYP19A1, ESR1, HSD17B2, INSR, SRC 2.19445
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 2.19445
[BP] GO:1900372 None ADRA2A, DRD2, DRD3, HTR1B 2.19021
[BP] GO:0030809 None ADRA2A, DRD2, DRD3, HTR1B 2.19021
[BP] GO:0051223 None ACHE, ADRA2A, APP, CNR1, DRD2, DRD3, EGFR, GSK3B, HTR2B, MMP12, PTGS2, PTPN1, SMAD3, SRC 2.18617
[BP] GO:0043279 None BCHE, CNR1, DRD2, DRD3, HTR1B 2.18518
[BP] GO:0051302 None AURKB, CDC25B, DRD2, DRD3, ESRRB, HTR2B 2.18518
[BP] GO:0060341 regulation of cellular localization ADRA2A, APP, AR, BCL2, CSNK2A1, DRD1, DRD2, DRD3, EGFR, GSK3B, PTGS2, PTPN1, SMAD3, SRC, TERT 2.17694
[BP] GO:0070213 None TNKS, TNKS2 2.17694
[BP] GO:0006145 None AOX1, XDH 2.17694
[BP] GO:0038171 None CNR1, CNR2 2.17694
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.17694
[BP] GO:0014827 None HTR1D, HTR2B 2.17694
[BP] GO:0043086 negative regulation of catalytic activity ADRA2A, APP, CNR1, CNR2, CSNK2A1, DRD2, DRD3, DUSP3, FABP4, GSK3B, IGF1R, MMP9, PTGS2, PTPN1, SRC 2.17219
[BP] GO:0035813 None ADORA1, DRD2, DRD3 2.17022
[BP] GO:0071880 None ADRA1A, ADRA2A, DRD2 2.17022
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, F3, MMP9, PTGS2, SMAD3, SRC, XDH 2.16328
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, APP, BCL2, DRD2, EGFR, GSK3B, HTR2B, MMP12, PTGS2, SMAD3, SRC 2.14872
[BP] GO:0014074 response to purine-containing compound APEX1, APP, PTGS2, SLC6A4, TEK, TYR 2.14812
[BP] GO:0045944 None APP, AR, DRD2, DRD3, EGFR, ESR1, ESRRA, ESRRB, MET, MMP12, NR3C1, PGR, PPARA, SMAD3, TERT, TNKS, TOP2A 2.14812
[BP] GO:0098657 import into cell ACHE, ADORA1, ALOX15, APP, AXL, DRD2, DRD3, HTR1B, HTR2B, SLC6A2, SLC6A4 2.14342
[BP] GO:1901653 cellular response to peptide AKR1B1, APEX1, APP, GSK3B, IGF1R, INSR, SRC 2.14086
[BP] GO:0050877 None ADORA1, APP, BCHE, CNR1, CNR2, CYP1B1, DRD1, DRD2, DRD3, EGFR, HTR2A, INSR, PTGS2, SLC6A4, TYR 2.13796
[BP] GO:0019219 regulation of nucleobase-containing compound metabolic process ADORA3, ADRA2A, APEX1, APP, AR, AURKB, CA9, CSNK2A1, CYP1B1, DHFR, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP4, GLO1, HSPA1A, HTR1B, HTR1E, HTR2A, IGF1R, INSR, MET, MMP12, NR3C1, NR3C2, PGR, PIK3CA, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A 2.13385
[BP] GO:0043434 None APEX1, FABP3, HSD11B2, INSR, PPARA, PTGS2, SRC, TEK 2.12813
[BP] GO:0007631 None APP, DRD1, DRD2, HTR1B, HTR2C 2.11543
[BP] GO:0043112 None ACHE, DRD2, DRD3, HTR1B, HTR2B 2.11543
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.11543
[BP] GO:0015844 None DRD1, SLC6A2, SLC6A4 2.11543
[BP] GO:0051968 None DRD1, EGFR, PTGS2 2.11543
[BP] GO:0042749 None ADORA1, DRD2, DRD3 2.11543
[BP] GO:0048729 tissue morphogenesis AR, BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.11456
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.11437
[BP] GO:0010676 None ESRRB, INSR, PPARA, SRC 2.11437
[BP] GO:0050994 None ADORA1, ADRA2A, CNR1, PPARA 2.11437
[BP] GO:0009266 None ADORA1, HSPA1A, HTR1B, HTR2A, HTR2B, PTGS2 2.09553
[BP] GO:0044283 None AKR1B1, ALOX15, ALOX5, CES1, CYP19A1, CYP1A1, DHFR, IDO1, PTGS1, PTGS2 2.09172
[BP] GO:0034762 None ADRA2A, APP, BCL2, CA2, DRD1, DRD2, DRD3, GPR35, KCNH2, MMP9 2.09172
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, EGFR, IGF1R, INSR, SRC, TNKS, TNKS2 2.0888
[BP] GO:0098900 None ADRA1A, CNR1, CNR2, GPR35 2.08665
[BP] GO:0007632 None APP, DRD1, DRD2, DRD3 2.08665
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.08665
[BP] GO:0030817 None ADRA2A, DRD1, DRD2, DRD3, HTR1B 2.06306
[BP] GO:0051194 None ESRRB, HTR2A, INSR 2.06306
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.06306
[BP] GO:0050995 None ADORA1, ADRA2A, CNR1 2.06306
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.05892
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.05892
[BP] GO:1901360 None ACHE, AKR1B1, AKR1B10, AOX1, APEX1, APP, AR, BCHE, BCL2, CES1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DHFR, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2B, HTR2C, IDO1, NR3C1, NR3C2, PGR, PPARA, PTGS2, RORC, SMAD3, TERT, TOP2A, TYR, XDH 2.05063
[BP] GO:1904062 None ADRA2A, APP, DRD1, DRD2, DRD3, GPR35, KCNH2, MMP9 2.05063
[BP] GO:0033138 positive regulation of peptidyl-serine phosphorylation APP, BCL2, EGFR, PIK3CA, PTGS2 2.04734
[BP] GO:1901184 None ADORA1, ADRA2A, APP, EGFR, MMP9 2.04734
[BP] GO:0045766 positive regulation of angiogenesis CYP1B1, F3, KDR, PTGS2, TEK, TERT 2.04461
[BP] GO:0032922 None DRD2, DRD3, PPARA, RORC 2.03179
[BP] GO:0051100 negative regulation of binding AURKB, CYP2D6, GSK3B, MET, PPARA, TNKS 2.03136
[BP] GO:0000904 cell morphogenesis involved in differentiation AR, AXL, MET, SRC, TEK 2.03015
[BP] GO:0030100 regulation of endocytosis ALOX15, APP, AXL, DRD2, PIK3CB, PTPN1, SRC 2.02739
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.01346
[BP] GO:0044062 None ADORA1, DRD2, DRD3 2.01346
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.01346
[BP] GO:0048589 None ADRA1A, APP, AR, BCL2, CYP19A1, ESR1, SMAD3, TNKS2 2.00771
[BP] GO:0046686 response to cadmium ion CYP1A2, EGFR, MMP9, TERT 2.00717
[BP] GO:1900180 regulation of protein localization to nucleus APP, EGFR, GSK3B, PTGS2, SMAD3, SRC, TERT 2.00717
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA1A, ADRA2A, APP, AXL, CA4, CNR1, CNR2, DRD1, DRD2, DRD3, F10, F3, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SIGMAR1, SLC6A2, SLC6A4, TEK 9.98638
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRA1A, ADRA2A, APP, AXL, CNR1, CNR2, DRD1, DRD2, DRD3, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SIGMAR1, SLC6A2, SLC6A4, TEK 8.53215
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ADRA1A, ADRA2A, ALOX15, APP, AXL, CA2, CA4, CA9, CNR1, CNR2, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNH2, KDR, MET, PTGS2, SIGMAR1, SLC6A2, SLC6A4, SRC, TEK 7.64823
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, ALOX15, ALPL, APP, AR, AXL, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ESR1, F10, F3, FLT3, GBA2, GLO1, GPR35, GSK3B, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNH2, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTPN1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT 7.64735
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, ALOX15, ALOX5, ALPL, APP, AR, AXL, BCHE, BCL2, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, EGFR, ESR1, F10, F3, FLT3, FUT7, GBA2, GLO1, GPR35, GSK3B, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNH2, KDR, MET, MMP2, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SIGMAR1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TYR 6.89654
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, ADRA1A, AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APEX1, APP, AR, AURKB, BCHE, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA7, CBR1, CDC25B, CDK6, CES1, CES2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DHFR, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR2A, HTR4, HTR5A, IDO1, INSR, KCNH2, KDR, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SIGMAR1, SLC6A4, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 4.96235
[CC] GO:0045121 membrane raft ADRA1A, APP, CNR1, EGFR, HTR2A, INSR, KDR, PTGS2, SLC6A2, SLC6A4, SRC, TEK 4.88459
[CC] GO:0098857 membrane microdomain ADRA1A, APP, CNR1, EGFR, HTR2A, INSR, KDR, PTGS2, SLC6A2, SLC6A4, SRC, TEK 4.85957
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, ALOX15, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, GBA2, GPR35, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNH2, KDR, MET, NR3C2, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, SIGMAR1, SLC6A2, SLC6A4, SRC, TEK, TYR 4.699
[CC] GO:0044432 endoplasmic reticulum part APP, BCHE, BCL2, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, EGFR, F10, FLT3, GBA2, HSD11B1, HSD11B2, HSD17B2, NR3C2, PTGS1, PTGS2, PTPN1, SIGMAR1 4.54573
[CC] GO:0098589 membrane region ADRA1A, APP, CNR1, EGFR, HTR2A, INSR, KDR, PTGS2, SLC6A2, SLC6A4, SRC, TEK 4.11094
[CC] GO:0005783 None ADORA1, APEX1, APP, BCL2, CA4, CES1, CES2, CYP19A1, CYP2D6, FLT3, GBA2, HSPA1A, HTR5A, KDR, PTGS2, PTPN1, SIGMAR1, XDH 3.31778
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, BCHE 3.25542
[CC] GO:0044464 cell part ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCHE, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA7, CA9, CBR1, CDC25B, CDK6, CES1, CES2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DHFR, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPR35, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IDO1, IGF1R, INSR, KCNH2, KDR, MET, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SIGMAR1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 3.13691
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, EGFR, GBA2, HSD11B1, HSD11B2, HSD17B2, NR3C2, PTGS1, PTGS2, SIGMAR1 2.93181
[CC] GO:0098590 plasma membrane region ADORA1, ADRA1A, ADRA2A, CA2, CA4, CA9, CNR1, DRD1, DRD2, EGFR, HTR2A, INSR, MET, PTGS2, SIGMAR1, SRC, TEK 2.64922
[CC] GO:0005901 caveola ADRA1A, HTR2A, INSR, PTGS2, SRC 2.61302
[CC] GO:0016323 basolateral plasma membrane ADORA1, ADRA2A, CA2, CA4, CA9, EGFR, TEK 2.38903
[CC] GO:0042995 cell projection ADORA1, AKR1B1, APP, CA2, CDK6, CNR1, CNR2, DRD1, DRD2, DRD3, HTR2A, HTR2B, HTR5A, HTR6, PIK3CA, PTGS2, SLC6A2, SLC6A4, SRC, TEK 2.28487
[CC] GO:0044853 plasma membrane raft ADRA1A, HTR2A, INSR, PTGS2, SRC 2.18518
[CC] GO:0031233 None CA4, F10, F3 2.17022
[CC] GO:0120025 None ADORA1, AKR1B1, APP, CA2, CDK6, CNR1, CNR2, DRD1, DRD2, HTR2A, HTR2B, HTR5A, HTR6, PIK3CA, PTGS2, SLC6A2, SLC6A4, SRC, TEK 2.16819
[CC] GO:0043227 membrane-bounded organelle ACHE, ADORA1, ADRA1A, AKR1B1, AKR1B10, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CBR1, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DHFR, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GSK3B, HSPA1A, HTR2A, HTR4, HTR5A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SIGMAR1, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 2.03136
[MF] GO:0043167 ion binding ACHE, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCHE, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DHFR, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, GSK3B, HSD17B1, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 19.9271
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, AOX1, APP, AR, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, TNKS, TYR, XDH 18.5979
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA1A, ADRA2A, AR, AXL, CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNH2, KDR, MET, NR3C1, NR3C2, PGR, PPARA, RORC, SIGMAR1, TEK 15.8248
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 15.6035
[MF] GO:0070405 ammonium ion binding ACHE, BCHE, DRD1, DRD2, DRD3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, SLC6A4 15.4878
[MF] GO:0008227 None ADRA1A, ADRA2A, DRD2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 15.4878
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, BCHE, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, GLO1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IDO1, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 15.386
[MF] GO:0043176 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 15.3009
[MF] GO:0051378 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 15.3009
[MF] GO:0004993 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 15.3009
[MF] GO:0099589 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 15.3009
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA1A, ADRA2A, AR, AXL, CDK6, CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNH2, KDR, MET, NR3C1, NR3C2, PGR, PPARA, RORC, SIGMAR1, TEK 14.7094
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA1A, ADRA2A, AR, AXL, CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNH2, KDR, MET, NR3C1, NR3C2, PGR, PPARA, RORC, SIGMAR1, TEK 14.3916
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA1A, ADRA2A, AR, AXL, CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNH2, KDR, MET, NR3C1, NR3C2, PGR, PPARA, RORC, SIGMAR1, SMAD3, TEK 13.6954
[MF] GO:0099528 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 12.9082
[MF] GO:0030594 None DRD1, DRD2, DRD3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 11.8338
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCHE, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DHFR, DUSP3, EGFR, F10, F3, FLT3, FUT7, GBA2, GLO1, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 11.476
[MF] GO:0042165 neurotransmitter binding ACHE, BCHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 11.3989
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PPARA, PTPN1, RORC, SMAD3, TNKS 11.1181
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DHFR, DRD1, DRD2, DRD3, EGFR, FLT3, GSK3B, HSPA1A, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, SIGMAR1, SLC6A4, SRC, TEK, TOP2A 10.7592
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.68459
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.60253
[MF] GO:0003707 steroid hormone receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, RORC 9.33647
[MF] GO:0005496 steroid binding AR, ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, NR3C1, NR3C2, PGR, RORC 9.09646
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRA1A, ADRA2A, AXL, CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SIGMAR1, TEK 9.02371
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRA1A, ADRA2A, AXL, CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SIGMAR1, TEK 9.02371
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DHFR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, NQO2, PTGS1, PTGS2, TYR, XDH 8.92652
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, F10, GLO1, IDO1, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 7.57515
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, ESR1, ESR2, ESRRA, ESRRB, PGR, PPARA, RORC 7.19984
[MF] GO:0004879 nuclear receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, PGR, PPARA, RORC 7.19984
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1 6.89654
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.44145
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, IDO1, PTGS1, PTGS2, SRC 6.30397
[MF] GO:0097159 organic cyclic compound binding ADORA1, ADRA2A, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DHFR, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GSK3B, HSD11B2, HSD17B1, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IDO1, IGF1R, INSR, KDR, MET, MMP12, NQO2, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, XDH 6.17309
[MF] GO:0004930 None ADORA1, ADORA3, ADRA1A, ADRA2A, CNR1, CNR2, DRD1, DRD2, DRD3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, SIGMAR1 6.15873
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, IDO1, PTGS1, PTGS2, SRC 6.0225
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 5.68094
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DHFR, HSD11B2, HSD17B1, IDO1, NQO2, PTGS1, PTGS2, SRC, XDH 5.64807
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, XDH 5.46593
[MF] GO:0042562 hormone binding ACHE, AR, EGFR, HSD17B1, IGF1R, INSR, NQO2, NR3C1 5.4562
[MF] GO:0008289 lipid binding ALOX15, AR, AXL, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HSD11B2, HSD17B1, NR3C1, NR3C2, PGR, PPARA, RORC 5.14981
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 5.01864
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 4.78102
[MF] GO:1901363 heterocyclic compound binding ADORA1, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DHFR, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GSK3B, HSD11B2, HSD17B1, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IDO1, IGF1R, INSR, KDR, MET, MMP12, NQO2, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, XDH 4.7274
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6 4.70861
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, GSK3B, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIM1, SRC, TEK 4.68604
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, PTGS1, PTGS2, TYR 4.5909
[MF] GO:0043560 insulin receptor substrate binding IGF1R, INSR, PIK3CA, PIK3CB 4.55271
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 4.53814
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, GSK3B, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 4.28995
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ADRA2A, APEX1, EGFR, ESRRB, FLT3, HTR2A, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SMAD3, SRC 4.23478
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, ADRA2A, APEX1, CSNK2A1, EGFR, ESRRB, FLT3, HTR2A, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SLC6A4, SMAD3, SRC 4.11775
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.0911
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, TYR 4.02602
[MF] GO:0042802 identical protein binding ACHE, ADRA2A, AOX1, APP, BCHE, BCL2, CSNK2A1, DRD2, EGFR, ESR1, ESR2, FLT3, IGF1R, KCNH2, KDR, MET, MMP9, NQO2, PGR, PTGS2, SLC6A4, SMAD3, TERT, TOP2A, TYR, XDH 3.90479
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, GSK3B, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 3.81304
[MF] GO:0019899 enzyme binding ADRA2A, APP, AR, AURKB, BCHE, BCL2, CDC25B, CYP1A1, CYP1A2, CYP2C19, DUSP3, EGFR, ESR1, ESR2, ESRRB, F3, GSK3B, HSPA1A, KCNH2, MET, NR3C1, PGR, PPARA, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TEK, TNKS2, TOP2A 3.71282
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, NQO2, XDH 3.69314
[MF] GO:1901338 None ADRA2A, DRD1, DRD2, DRD3 3.53833
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, GSK3B, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TERT 3.44843
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.4467
[MF] GO:0003674 molecular_function ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCHE, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CES1, CES2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DHFR, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPR35, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IDO1, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SIGMAR1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 3.24683
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX15, ALOX5, IDO1, PTGS2 3.12558
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.10243
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.0648
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX15, ALOX5, IDO1, PTGS2 3.0648
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.94889
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.82616
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.82616
[MF] GO:0003990 acetylcholinesterase activity ACHE, BCHE 2.82616
[MF] GO:0003845 None HSD11B1, HSD11B2 2.82616
[MF] GO:0071886 None HTR2A, HTR2C 2.82616
[MF] GO:0046983 protein dimerization activity ACHE, ADORA1, ADRA1A, ADRA2A, AOX1, AR, AXL, BCL2, DRD2, EGFR, FLT3, KCNH2, NQO2, PTGS2, SLC6A4, SMAD3, TERT, TOP2A, TYR, XDH 2.77638
[MF] GO:0004952 None DRD1, DRD2, DRD3 2.75844
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2C19, CYP2D6 2.72511
[MF] GO:0035240 None DRD1, DRD2, DRD3 2.66022
[MF] GO:0042803 protein homodimerization activity ACHE, ADRA2A, AOX1, BCL2, DRD2, FLT3, KCNH2, NQO2, PTGS2, SLC6A4, SMAD3, TERT, TOP2A, TYR, XDH 2.60699
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.42548
[MF] GO:0004949 None CNR1, CNR2 2.42548
[MF] GO:0005330 None SLC6A2, SLC6A4 2.42548
[MF] GO:0004104 cholinesterase activity ACHE, BCHE 2.42548
[MF] GO:0047374 None CES1, CES2 2.42548
[MF] GO:0004935 None ADRA1A, ADRA2A, DRD2 2.42111
[MF] GO:0008013 beta-catenin binding AR, CSNK2A1, ESR1, GSK3B, SMAD3 2.36573
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.34683
[MF] GO:0008134 transcription factor binding APEX1, AR, BCL2, ESR1, ESRRB, FLT3, GSK3B, PIM1, PPARA, SMAD3, SRC, TERT 2.21893
[MF] GO:0051213 dioxygenase activity ALOX15, ALOX5, IDO1, PTGS1, PTGS2 2.19996
[MF] GO:0052689 carboxylic ester hydrolase activity ACHE, BCHE, CA1, CA2, CES1, CES2 2.19639
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.17694
[MF] GO:0032795 None ADORA1, ADRA2A 2.17694
[MF] GO:0051425 None APP, INSR 2.17694
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.17022


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Serotonergic synapse_Homo sapiens_hsa04726 APP, HTR1E, ALOX15, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, HTR2A, PTGS2, HTR5A, HTR4, CYP2C19, PTGS1, SLC6A4, HTR6, HTR7, CYP2D6, ALOX5 20.1948
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 HTR1E, GPR35, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, HTR2A, NR3C1, HTR5A, HTR4, ADRA1A, ADRA2A, HTR6, HTR7, CNR2, CNR1, ADORA3, ADORA1, DRD1, DRD2, DRD3 16.6323
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 16.616
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 9.4165
cAMP signaling pathway_Homo sapiens_hsa04024 HTR6, PIK3CA, HTR1E, HTR1D, ADORA1, HTR1A, HTR1B, PIK3CB, DRD1, DRD2, PPARA, HTR4 7.3931
Pathways in cancer_Homo sapiens_hsa05200 GSK3B, SMAD3, FLT3, MMP1, MMP2, PIK3CB, PTGS2, MMP9, EGFR, IGF1R, AR, CDK6, PIK3CA, BCL2, MET 6.8184
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, EGFR, ESR2, HSPA1A 6.9197
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 7.3931
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 6.7602
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, CNR1, INSR, KDR, TEK, PIK3CB, DRD2, MET, EGFR, IGF1R 6.2997
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, INSR, ADORA1, PIK3CB, PTGS2, PTGS1 6.308
Calcium signaling pathway_Homo sapiens_hsa04020 HTR6, HTR7, HTR2B, HTR2C, HTR2A, DRD1, HTR5A, HTR4, ADRA1A, EGFR 5.957
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, EGFR, IGF1R 5.5038
Metabolic pathways_Homo sapiens_hsa01100 CBR1, ALOX15, AKR1B1, PTGS2, TYR, CYP2C19, GBA2, CYP19A1, PTGS1, DHFR, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, IDO1, CES1 5.3467
Prostate cancer_Homo sapiens_hsa05215 AR, GSK3B, PIK3CA, BCL2, PIK3CB, EGFR, IGF1R 5.1321
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, PIK3CA, MMP2, BCL2, PIM1, PIK3CB, F3 4.8072
Gap junction_Homo sapiens_hsa04540 SRC, HTR2B, HTR2C, HTR2A, DRD1, DRD2, EGFR 5.1393
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP2C19 5.3218
Focal adhesion_Homo sapiens_hsa04510 GSK3B, PIK3CA, SRC, KDR, BCL2, PIK3CB, MET, EGFR, IGF1R 4.7352
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, INSR, BCL2, TEK, PIK3CB, EGFR, IGF1R 4.7721
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, PTGS2, CYP2C19, PTGS1 4.8811
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 GSK3B, CDK6, PIK3CA, INSR, KDR, BCL2, TEK, PIK3CB, MET, EGFR, IGF1R 4.6334
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, PIK3CA, INSR, KDR, TEK, PIK3CB, MET, EGFR, IGF1R 4.4614
Melanoma_Homo sapiens_hsa05218 CDK6, PIK3CA, PIK3CB, MET, EGFR, IGF1R 4.6568
Prolactin signaling pathway_Homo sapiens_hsa04917 GSK3B, PIK3CA, SRC, PIK3CB, ESR1, ESR2 4.6461
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, PIK3CA, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, EGFR, CDC25B 4.3749
Hepatitis B_Homo sapiens_hsa05161 CDK6, SMAD3, PIK3CA, SRC, BCL2, PIK3CB, MMP9 3.969
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, HTR2B, HTR2C, PIK3CB, HTR2A 3.969
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP2D6, CYP1A2, CYP1A1, CYP1B1 4.6368
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, PIK3CA, INSR, PIK3CB, NR3C2 4.6842
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1, IDO1 4.6568
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, INSR, ADORA1, PIK3CB, ADRA1A, ADRA2A 3.6975
Insulin resistance_Homo sapiens_hsa04931 PTPN1, GSK3B, PIK3CA, INSR, PIK3CB, PPARA 3.7815
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 3.8891
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 4.6461
Glioma_Homo sapiens_hsa05214 CDK6, PIK3CA, PIK3CB, EGFR, IGF1R 3.7921
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, INSR, PIK3CB, IGF1R, HSPA1A 3.8125
Colorectal cancer_Homo sapiens_hsa05210 GSK3B, SMAD3, PIK3CA, BCL2, PIK3CB 3.8674
Measles_Homo sapiens_hsa05162 GSK3B, CDK6, CSNK2A1, PIK3CA, PIK3CB, HSPA1A 3.2895
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, PIK3CA, INSR, PIK3CB, EGFR, IGF1R 3.3323
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, SMAD3, PIK3CA, PIK3CB, EGFR 3.7815
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 GSK3B, SMAD3, PIK3CA, ESRRB, PIK3CB, IGF1R 3.2167
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET, EGFR 3.7627
ErbB signaling pathway_Homo sapiens_hsa04012 GSK3B, PIK3CA, SRC, PIK3CB, EGFR 3.2714
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PGR, PIK3CB, CDC25B, IGF1R 3.057
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, PIK3CA, BCL2, PIK3CB, PTGS2 3.2852
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 2.6817
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 GSK3B, PIK3CA, SRC, PIK3CB, ESR1 2.7289
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB, HSPA1A 2.7289
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, BCL2, ADORA1, PIK3CB 2.712
Epstein-Barr virus infection_Homo sapiens_hsa05169 GSK3B, CSNK2A1, PIK3CA, BCL2, PIK3CB, HSPA1A 2.5423
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, INSR, PIK3CB, ADRA1A, IGF1R 2.6782
Hepatitis C_Homo sapiens_hsa05160 GSK3B, PIK3CA, PIK3CB, PPARA, EGFR 2.5558
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 GSK3B, PIK3CA, INSR, PIK3CB, PPARA 2.3458
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, GSK3B, PIK3CA, INSR, PIK3CB 2.4915
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, AOX1, PIK3CB 2.2793
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2, EGFR 2.2793
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6, PIK3CA, PIK3CB, EGFR 2.9863
Endometrial cancer_Homo sapiens_hsa05213 GSK3B, PIK3CA, PIK3CB, EGFR 3.093
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 2.9658
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6, SMAD3, PIK3CA, PIK3CB 2.6364
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, INSR, PIK3CB, IGF1R 2.2793
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, PIK3CA, BCL2, PIK3CB 2.0594
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.0675
Taste transduction_Homo sapiens_hsa04742 HTR1E, HTR1D, HTR1A, HTR1B 2.4629
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 1.9311
Neurotrophin signaling pathway_Homo sapiens_hsa04722 GSK3B, PIK3CA, BCL2, PIK3CB 1.9508
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2D6, CYP1A2, AOX1, CYP2C19 2.7062
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 2.5427
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 1.9706
Dopaminergic synapse_Homo sapiens_hsa04728 GSK3B, DRD1, DRD2, DRD3 1.8671
Cell cycle_Homo sapiens_hsa04110 GSK3B, CDK6, SMAD3, CDC25B 1.9119
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.1864
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, INSR, PIK3CB, EGFR 1.7242
HTLV-I infection_Homo sapiens_hsa05166 GSK3B, SMAD3, PIK3CA, TERT, PIK3CB 1.5133
Purine metabolism_Homo sapiens_hsa00230 XDH 0.1963
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.7062
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PIK3CB, ADRA1A 1.6887
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.2682
Influenza A_Homo sapiens_hsa05164 GSK3B, PIK3CA, PIK3CB, HSPA1A 1.4802
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.4483
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, PIK3CA, SRC, PIK3CB 1.2935
Vascular smooth muscle contraction_Homo sapiens_hsa04270 ADRA1A 0.2984
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 PIK3CA, SRC, PIK3CB, EGFR 1.2499
Chemokine signaling pathway_Homo sapiens_hsa04062 GSK3B, PIK3CA, SRC, PIK3CB 1.4125
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.0072
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.1304
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.0485
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.5306
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.3499
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.5099
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.5099
Alzheimer's disease_Homo sapiens_hsa05010 GSK3B, APP 0.5306
Hippo signaling pathway_Homo sapiens_hsa04390 GSK3B, SMAD3 0.5724
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.6146
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.3647
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.3638
Wnt signaling pathway_Homo sapiens_hsa04310 GSK3B, SMAD3, CSNK2A1 1.1215
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.6254
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.5287
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 0.6353
Oocyte meiosis_Homo sapiens_hsa04114 AR, PGR, IGF1R 1.2524
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.647
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.3837
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB, EGFR 1.4421
Axon guidance_Homo sapiens_hsa04360 GSK3B, MET 0.6666
Salivary secretion_Homo sapiens_hsa04970 ADRA1A 0.3837
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.3837
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3, PIK3CA, PIK3CB 1.4179
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.3928
T cell receptor signaling pathway_Homo sapiens_hsa04660 GSK3B, PIK3CA, PIK3CB 1.4179
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.3837
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 0.7683
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 1.5133
Peroxisome_Homo sapiens_hsa04146 XDH 0.3943
Melanogenesis_Homo sapiens_hsa04916 GSK3B, TYR 0.803
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 0.803
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 0.8066
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 0.841
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1, PTGS2 0.7991
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 0.8496
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 0.8539
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.4174
B cell receptor signaling pathway_Homo sapiens_hsa04662 GSK3B, PIK3CA, PIK3CB 1.7622
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.4306
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4285
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4399
Bile secretion_Homo sapiens_hsa04976 CA2 0.4376
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.4423
Amphetamine addiction_Homo sapiens_hsa05031 DRD1 0.45
Shigellosis_Homo sapiens_hsa05131 SRC 0.458
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.4608
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 1.8671
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.4814
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 0.9469
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 1.8365
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 1.8745
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.0485
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.02
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.5099
Basal cell carcinoma_Homo sapiens_hsa05217 GSK3B 0.5099
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.1304
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.5271
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.0761
Malaria_Homo sapiens_hsa05144 MET 0.5306
Hedgehog signaling pathway_Homo sapiens_hsa04340 GSK3B 0.5306
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.54
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.5351
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.1353
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.54
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, INSR, PIK3CB 2.1999
Cocaine addiction_Homo sapiens_hsa05030 DRD1, DRD2 1.2655
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH, CES2, CES1 2.2467
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.5926
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.6353
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.6353
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.3253
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.6666
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.7086
Base excision repair_Homo sapiens_hsa03410 APEX1 0.647
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP2C19 2.7203
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.6834
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.5976
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7169
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.6733
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.494
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.5487
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7086
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.4802
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8011
One carbon pool by folate_Homo sapiens_hsa00670 DHFR 0.806
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.841
Folate biosynthesis_Homo sapiens_hsa00790 DHFR, ALPL 2.1682
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2499
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 2.9606


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)