TCM Prescription: Qi Zhu Jian Wei Tea



Prescription Description
Prescription IDTCMF7080
Pinyin NameQi Zhu Jian Wei Cha
Chinese Name七珠健胃茶
English NameQi Zhu Jian Wei Tea
Function Description行气健脾, 消积导滞, 清热利湿。用于脾虚食滞所引起的消化不良, 精神疲倦, 并对肥胖症, 高血压, 高血脂表现为上述症状者有辅助治疗作用。
IndicationsDyspepsia
Disease ICD-11 Category MD92 [Dyspepsia, 消化不良 ];
Human Tissues Associated with IndicationIntestine, Stomach
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1848 Crataegus pinnatifida 山楂 TCMH1848 ITSAH1684-14
TCMH2244 Prunella vulgaris 夏枯草 TCMH2244 ITSAH2424-14
TCMH1181 Chrysanthemum morifolium 菊花 TCMH1181 KX675020
TCMH1240 Raphanus sativus 莱菔子 TCMH1240 ITSAD4259-14
TCMH243 Pericarpium citri reticulatae 陈皮 TCMH243
TCMH1768 Panax notoginseng 三七 TCMH1768 ITSAO2360-14
TCMH436 Fructus oryzae germinatus 稻芽 TCMH436
TCMH426 Codonopsis pilosula 党参 TCMH426 ITSAL4530-14
TCMH1728 Panax ginseng 人参叶 TCMH1728 GBVE1679-11
TCMH1199 Cassia tora 决明子 TCMH1199 GENG109-13
TCMH226 Camellia sinensis 茶叶 TCMH226 ITSAG2924-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT158 EPHX2 Epoxide hydratase Lyase P34913
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT197 PDE4D Phosphodiesterase 4D Hydrolase Q08499
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT304 MMP14 Matrix metalloproteinase 14 Hydrolase P50281
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT567 DNMT1 DNA (cytosine-5)-methyltransferase 1 Transferase P26358
TCMT571 ADORA2B Adenosine A2b receptor GPCR P29275
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT64 PPARD Peroxisome proliferator-activated receptor delta Nuclear receptor Q03181
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT698 PDE4B Phosphodiesterase 4B Hydrolase Q07343
TCMT707 ADORA2A Adenosine A2a receptor GPCR P29274
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT781 CYP2E1 Cytochrome P450 2E1 Oxidoreductase P05181
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT848 ERN1 Serine/threonine-protein kinase/endoribonuclease IRE1 Kinase O75460
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT884 PHF8 Histone lysine demethylase PHF8 Oxidoreductase Q9UPP1
TCMT965 KDM7A Lysine-specific demethylase 7 Oxidoreductase Q6ZMT4


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1172 Staphylococcus aureus subsp. aureus RN4220
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1189 Pseudomonas fluorescens
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1283 Human enterovirus 71
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1292 Japanese encephalitis virus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1336 Yellow fever virus
TCMT1337 Dengue virus type 4
TCMT1338 Rift Valley fever virus
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1393 Vibrio sp.
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EPHX2, ESR1, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, PIK3CA, PIK3CB, PPARA, PPARD, PTGS1, PTGS2 10.9302
[BP] GO:0008152 metabolic process ACHE, ADORA1, ADORA2A, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, DYRK1A, EPHX2, ESR1, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 9.75099
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, FABP3, HSD17B2, IGF1R, MMP2, MMP9, PIK3CA, PPARA, PPARD, PTGS2, RORC, SRC, TYR 9.58504
[BP] GO:0044281 small molecule metabolic process ADORA2A, AKR1B1, AKR1B10, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EPHX2, FABP3, FUT7, GLO1, PIK3CA, PIM1, PPARA, PPARD, PTGS1, PTGS2, TYR, XDH 9.28822
[BP] GO:0042221 response to chemical ABCB1, ADORA2A, AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EPHX2, ESR1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, MMP9, PIK3CA, PPARA, PPARD, PTGS2, RORC, SRC, TERT, TYR 9.23906
[BP] GO:0044237 cellular metabolic process ACHE, ADORA2A, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, DYRK1A, EPHX2, ESR1, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, NQO2, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 9.14421
[BP] GO:0010941 regulation of cell death ADORA1, ADORA2A, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, HCAR2, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PTGS2, PTPN1, SRC, TERT, TOP2A, XDH 9.03756
[BP] GO:0043067 regulation of programmed cell death ADORA1, ADORA2A, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, HCAR2, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARD, PTGS2, PTPN1, SRC, TERT, TOP2A, XDH 8.98144
[BP] GO:0010033 response to organic substance ADORA2A, AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, PIK3CA, PPARA, PPARD, PTGS2, RORC, SRC, TYR 8.668
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, ADORA2A, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, EPHX2, ESR1, FABP3, FABP4, FLT3, HCAR2, HSD17B1, HSD17B2, KDR, MET, PIK3CA, PIK3CB, PPARA, PPARD, PTGS1, PTGS2, SRC, TERT, TNKS, TNKS2, XDH 8.65147
[BP] GO:0032502 developmental process ACHE, ADORA1, ADORA2A, AKR1B1, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CBR1, CDC25B, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, ESR1, FABP4, FLT3, FUT7, GLO1, HSD17B2, KDR, MET, MMP2, MMP9, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PTGS2, RORC, SRC, TERT, TNKS2, TOP2A, TYR 8.64872
[BP] GO:0042981 regulation of apoptotic process ADORA1, ADORA2A, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, HCAR2, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PPARD, PTGS2, PTPN1, SRC, TERT, TOP2A, XDH 8.32851
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADORA2A, AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HCAR2, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARD, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 8.32277
[BP] GO:0023056 positive regulation of signaling ADORA1, ADORA2A, AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HCAR2, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARD, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 8.32277
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, ADORA2A, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, EPHX2, ESR1, FABP3, FABP4, FLT3, HCAR2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 8.31753
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADORA2A, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, ESR1, FABP3, FLT3, HCAR2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 8.12249
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR 8.01192
[BP] GO:0019369 arachidonic acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EPHX2, PTGS1, PTGS2 7.84013
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA2A, ADORA3, AKR1B1, APP, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, DNMT1, ESR1, FABP3, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PPARD, PTGS1, PTGS2, SRC, TERT, XDH 7.71835
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, FABP3, FLT3, HSD17B2, PPARD, PTGS2, RORC, SRC, TYR 7.41717
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EPHX2, PTGS1, PTGS2 7.3358
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, PTGS2, SRC, TERT 7.32281
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, HSD17B1, HSD17B2, PPARD 7.32281
[BP] GO:0060548 negative regulation of cell death ADORA1, ADORA2A, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PPARD, PTGS2, PTPN1, SRC, TERT 7.31696
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EPHX2, FABP3, FABP4, FUT7, MET, PIK3CA, PIK3CB, PPARA, PPARD, PTGS1, PTGS2 7.22583
[BP] GO:0006690 icosanoid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EPHX2, PTGS1, PTGS2 7.12956
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, ADORA2A, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARD, PTGS2, PTPN1, SRC, TERT 7.12396
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, PIK3CA, PPARD, PTGS2, RORC, SRC, TERT 7.11916
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.95756
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HSD17B1, HSD17B2, NQO2, PHF8, PPARD, PTGS1, PTGS2, TYR, XDH 6.93517
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, ADORA2A, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, DYRK1A, EPHX2, ESR1, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 6.60049
[BP] GO:0014070 response to organic cyclic compound ADORA2A, ALPL, APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, PTGS2, RORC, SRC, TYR 6.6002
[BP] GO:0006631 fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EPHX2, FABP3, PPARA, PPARD, PTGS1, PTGS2 6.56055
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA2A, ADORA3, AKR1B1, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EPHX2, ESR1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PPARD, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A, TYR 6.52207
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, ADORA2A, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, IGF1R, KDR, MMP9, PIK3CA, PIM1, PPARD, PTGS2, PTPN1, SRC, TERT 6.43613
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CDK6, CYP1A1, CYP1B1, DNMT1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, PIK3CA, PPARD, PTGS2, RORC, SRC 6.42674
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA2A, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DNMT1, DYRK1A, ESR1, FABP3, FABP4, GLO1, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PIK3CA, PIM1, PPARA, PPARD, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 6.32199
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADORA2A, AURKB, BCL2, CA2, CA7, CDK6, HCAR2, KDR, PIK3CB, PTGS2, SRC, TNKS, TNKS2 6.31172
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADORA2A, AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, FLT3, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARD, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 6.2955
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ADORA2A, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, EPHX2, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PPARD, PTGS2, PTPN1, SRC, TNKS, XDH 6.2955
[BP] GO:0001676 long-chain fatty acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EPHX2, PTGS1, PTGS2 5.97965
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.91235
[BP] GO:0006793 phosphorus metabolic process ACHE, ADORA2A, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, EPHX2, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PPARD, PTGS2, PTPN1, SRC, TNKS, XDH 5.89467
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, ADORA2A, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, DYRK1A, EPHX2, ESR1, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 5.85593
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EPHX2, PTGS1, PTGS2 5.8046
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA2A, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DNMT1, DYRK1A, ESR1, FABP3, FABP4, GLO1, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PIK3CA, PIM1, PPARA, PPARD, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 5.63012
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, PIK3CA, PPARD, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A 5.62532
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADORA2A, AKR1B1, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, ESR1, FLT3, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARD, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 5.62266
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DNMT1, ESR1, FABP3, FLT3, IGF1R, MMP2, PPARA, PTGS2, SRC 5.6098
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AXL, CDK6, CYP1B1, DNMT1, ESR1, IGF1R, MMP2, MMP9, PIK3CA, PPARD, PTGS2, RORC, SRC 5.6098
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6, EPHX2, NQO2, PTGS1, RORC 5.60919
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADORA2A, AKR1B1, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, ESR1, FLT3, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARD, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 5.51572
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA2A, ADORA3, APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PPARD, PTGS2, SRC, TERT 5.44587
[BP] GO:0032787 None ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EPHX2, FABP3, GLO1, PPARA, PPARD, PTGS1, PTGS2 5.38681
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADORA2A, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EPHX2, ESR1, FABP3, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PIK3CA, PIK3CB, PPARA, PPARD, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 5.32039
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADORA2A, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, ESR1, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PIK3CA, PIK3CB, PPARA, PPARD, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 5.26155
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PPARD, PTGS2, SRC, TERT 5.13379
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA2A, ADORA3, APEX1, APP, AXL, BCL2, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1B1, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, PIK3CB, PPARA, PPARD, PTGS2, PTPN1, SRC, TERT 5.04934
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, ADORA2A, AKR1B1, ALPL, APP, AXL, BCL2, CA2, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, ESR1, FLT3, HSD17B2, KDR, MMP9, PHF8, PIK3CA, PIM1, PPARA, PPARD, PTGS2, RORC, SRC, TYR 4.98704
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADORA2A, APP, AURKB, BCL2, CDC25B, DNMT1, DYRK1A, ESR1, FABP3, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PIK3CA, PIK3CB, PPARA, PPARD, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 4.92986
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EPHX2, FABP3, FABP4, FUT7, MMP1, MMP12, MMP2, MMP9, PIK3CB, PPARD, SRC, XDH 4.90986
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EPHX2, ESR1, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PIK3CA, PIK3CB, PPARA, PPARD, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 4.88834
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADORA2A, AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, FABP4, FLT3, KDR, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARD, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 4.85463
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, ESR1, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PPARD, PTGS2, TERT 4.74896
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, PPARA, PTGS2, SRC 4.72994
[BP] GO:0009892 negative regulation of metabolic process ADORA1, ADORA2A, APEX1, APP, AURKB, BCL2, CSNK2A1, CYP2D6, DNMT1, DYRK1A, ESR1, FABP4, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PPARA, PPARD, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 4.72943
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PPARD, PTGS2, SRC, TERT 4.72564
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PPARD, PTGS2, SRC, TERT 4.70962
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, ADORA2A, AKR1B1, ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, DYRK1A, ESR1, FLT3, FUT7, GLO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIK3CA, PIM1, PPARA, PPARD, PTGS2, PTPN1, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 4.68726
[BP] GO:0044092 negative regulation of molecular function ADORA2A, ADORA3, APP, AURKB, CSNK2A1, CYP1B1, CYP2D6, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS 4.623
[BP] GO:0032846 positive regulation of homeostatic process ADORA2A, AURKB, CA2, CA7, HCAR2, PIK3CB, PTGS2, TNKS, TNKS2 4.57805
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, ADORA2A, APP, CDK6, CYP19A1, DYRK1A, ESR1, FABP4, IGF1R, MET, MMP12, MMP2, PPARA, PPARD, PTGS2, PTPN1, SRC, TERT, XDH 4.57112
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.56469
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, FLT3, HSD17B2, KDR, PHF8, PIK3CA, PPARA, PPARD, SRC, TYR 4.53666
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, MET, PIK3CA, PIM1, SRC, TNKS 4.47032
[BP] GO:0009636 response to toxic substance ADORA2A, AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, EPHX2, KDR, SRC 4.40231
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.39907
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DYRK1A, ESR1, FLT3, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PPARD, PTGS2, PTPN1, SRC, XDH 4.38753
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APEX1, APP, AXL, BCL2, CA12, CA2, CA7, EPHX2, ESR1, FABP3, FABP4, FLT3, MET, PIK3CA, PIK3CB, SRC, TERT 4.38753
[BP] GO:0032501 multicellular organismal process ADORA1, ADORA2A, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, EPHX2, ESR1, FABP4, HSD17B2, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PPARD, PTGS2, RORC, SRC, TNKS2, TYR 4.35864
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADORA2A, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HCAR2, HSD17B1, HSD17B2, PPARD 4.31173
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, PPARD 4.26063
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AXL, BCL2, CYP1B1, FLT3, KDR, MET, PIK3CA, PIK3CB, PPARD, PTGS2, PTPN1, SRC, XDH 4.26063
[BP] GO:0042493 response to drug ABCB1, ADORA2A, AKR1B1, APEX1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, FABP3, KDR, PTGS2, SRC 4.23869
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EPHX2, FABP3, GLO1, PIM1, PPARA, PPARD, PTGS1, PTGS2, TYR 4.21648
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.18914
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, MMP2, PPARA, PPARD, PTGS2, SRC, TERT 4.1484
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA2A, ADORA3, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, DYRK1A, EPHX2, ESR1, FABP3, FABP4, FLT3, GLO1, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 4.13056
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, BCL2, CYP1B1, MMP9, PTGS1, PTGS2, SRC 4.13056
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, CYP2D6, MET, MMP9, PPARA, SRC, TERT, TNKS 4.13056
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, MMP2, PPARA, PPARD, PTGS2, SRC, TERT 4.05646
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC, TNKS 4.05646
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, APP, CYP1A1, CYP1B1, ESR1, FLT3, PTGS2, RORC, SRC 4.05074
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, BCL2, CYP1A1, ESR1, FLT3, MET, PIK3CB, PIM1, PPARD, SRC, TYR 4.04041
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, PIM1, SRC 4.03417
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PPARD, PTGS1, PTGS2 3.98934
[BP] GO:0031324 negative regulation of cellular metabolic process ADORA2A, APEX1, APP, AURKB, BCL2, CSNK2A1, CYP2D6, DNMT1, DYRK1A, ESR1, FABP4, IGF1R, MET, MMP12, MMP9, PIK3CA, PPARA, PPARD, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 3.9405
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, EPHX2, FABP3, FLT3, HCAR2, PPARA, PTGS2, RORC, SRC 3.94035
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT 3.90521
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA1, ADORA2A, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, DYRK1A, EPHX2, ESR1, FABP3, FABP4, FLT3, FUT7, GLO1, HCAR2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 3.87431
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DYRK1A, ESR1, PPARA, RORC, SRC, TOP2A 3.87431
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, ADORA2A, AKR1B1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, ESR1, FABP4, FLT3, IGF1R, KDR, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PPARD, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 3.87431
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, EPHX2 3.81779
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, MMP2, PPARA, PPARD, PTGS2, SRC, TERT 3.7941
[BP] GO:0043436 oxoacid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EPHX2, FABP3, GLO1, PIM1, PPARA, PPARD, PTGS1, PTGS2, TYR 3.75044
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, ADORA1, ADORA2A, APP, AXL, BCL2, CA2, CYP19A1, HCAR2, MMP12, PPARD, PTGS2, SRC, TERT 3.67584
[BP] GO:0006082 organic acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EPHX2, FABP3, GLO1, PIM1, PPARA, PPARD, PTGS1, PTGS2, TYR 3.66804
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA2A, ADORA3, AKR1B1, APEX1, APP, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EPHX2, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PPARD, PTGS1, PTGS2, PTPN1, SRC, TERT, TOP2A 3.63553
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 3.61631
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.60326
[BP] GO:0010038 response to metal ion APP, BCL2, CA2, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2, TERT 3.49839
[BP] GO:0048869 cellular developmental process ACHE, ADORA2A, ALPL, APP, AXL, BCL2, CBR1, CDC25B, CDK6, CYP1A1, ESR1, FABP4, FLT3, FUT7, GLO1, KDR, MET, MMP2, MMP9, PPARD, PTGS2, RORC, SRC, TERT, TOP2A 3.47737
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TERT, TNKS, TNKS2 3.46033
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP2D6, PHF8 3.46033
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PPARD 3.44359
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC 3.42627
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 3.42627
[BP] GO:0010243 response to organonitrogen compound ADORA2A, AKR1B1, APEX1, APP, DNMT1, FABP3, FLT3, IGF1R, MMP2, PPARA, PTGS2, SRC, TYR 3.40392
[BP] GO:2001251 None DNMT1, PHF8, SRC, TNKS, TNKS2, TOP2A 3.36915
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, MMP9, SRC 3.36166
[BP] GO:0009966 regulation of signal transduction ADORA1, ADORA2A, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DYRK1A, ESR1, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARD, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 3.32662
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADORA2A, BCL2, CDK6, CYP19A1, DYRK1A, ESR1, IGF1R, MET, MMP12, MMP9, PPARA, PPARD, PTGS2, PTPN1, SRC, TERT, XDH 3.31639
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, PPARD 3.30311
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA2A, ADORA3, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, EPHX2, ESR1, FABP3, FABP4, FLT3, GLO1, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 3.28947
[BP] GO:0001973 None ADORA1, ADORA2A, ADORA3 3.28368
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA2A, ADORA3, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, EPHX2, ESR1, FABP4, FLT3, GLO1, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 3.26008
[BP] GO:0014910 regulation of smooth muscle cell migration APEX1, BCL2, PPARD, SRC, TERT 3.23855
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, DYRK1A, FLT3, IGF1R, KDR, MET, SRC 3.20208
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, ADORA2A, APP, CA2, CA7, PTGS2 3.1893
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, ADORA2A, APP, AXL, BCL2, CA2, CA7, CYP19A1, HCAR2, MMP12, MMP9, PIK3CB, PPARA, PPARD, PTGS2, PTPN1, SRC, TERT 3.17487
[BP] GO:0018212 peptidyl-tyrosine modification AXL, DYRK1A, FLT3, IGF1R, KDR, MET, SRC 3.16966
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, ADORA2A, CA2, CA7 3.16966
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.16043
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.16043
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, PPARD 3.15359
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PPARD 3.12935
[BP] GO:0019538 protein metabolic process ACHE, ADORA2A, ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, ESR1, FLT3, FUT7, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIK3CA, PIM1, PPARA, PPARD, PTPN1, SRC, TNKS, TNKS2, TOP2A 3.12623
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 3.11613
[BP] GO:1901698 response to nitrogen compound ADORA2A, AKR1B1, APEX1, APP, DNMT1, FABP3, FLT3, IGF1R, MMP2, PPARA, PTGS2, SRC, TYR 3.11568
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, PPARD, PTGS2, TERT 3.08532
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADORA2A, APP, BCL2, CDC25B, FABP3, FLT3, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.08532
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADORA2A, APP, BCL2, CDC25B, FABP3, FLT3, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.08532
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA2A, ADORA3, APP, BCL2, CDK6, CYP1B1, FABP3, PPARD, PTGS2, TERT, XDH 3.07828
[BP] GO:0019371 None CBR1, PTGS1, PTGS2 3.05427
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CDK6, CYP1B1, KDR, PTGS2, SRC 3.0461
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, PTGS2, TERT 3.02561
[BP] GO:0065007 biological regulation ABCB1, ACHE, ADORA1, ADORA2A, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, DYRK1A, EPHX2, ESR1, FABP3, FABP4, FLT3, GLO1, HCAR2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 2.97723
[BP] GO:2000021 regulation of ion homeostasis ADORA1, ADORA2A, BCL2, CA2, CA7, KDR, SRC 2.95049
[BP] GO:0007566 embryo implantation MMP2, MMP9, PPARD, PTGS2 2.92029
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, MMP2, PPARA, PPARD, PTGS2, SRC, TERT, TYR 2.90676
[BP] GO:0044070 regulation of anion transport ABCB1, ADORA1, ADORA2A, CA2, CA7 2.88511
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, PPARD, PTGS2, TYR 2.88511
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, ADORA2A, APP, BACE1, CA2, CA7, PTGS2 2.87117
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, ADORA2A, APP, BACE1, CA2, CA7, PTGS2 2.87117
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.85582
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic ADORA2A, CA2, CA7 2.85582
[BP] GO:1901989 None APEX1, APP, CDC25B, CYP1A1, TERT 2.84773
[BP] GO:0009891 positive regulation of biosynthetic process ADORA2A, APP, AURKB, ESR1, FABP3, IGF1R, KDR, MET, MMP12, PHF8, PPARA, PPARD, PTGS2, RORC, SRC, TERT, TNKS, TNKS2, TOP2A 2.84192
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DYRK1A, ESR1, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 2.79565
[BP] GO:0040013 None ADORA1, ADORA2A, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, PPARD 2.79451
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA2A, ADORA3, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DNMT1, DYRK1A, ESR1, FABP3, FABP4, FLT3, GLO1, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 2.78546
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.76791
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, PPARD, TYR 2.7571
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADORA2A, APP, BCL2, CDC25B, FABP4, FLT3, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 2.74992
[BP] GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ADORA2A, CSNK2A1, MMP9, PTGS2, SRC 2.72153
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA2A, ADORA3, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, CYP2D6, ESR1, FABP4, FLT3, IGF1R, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, TERT, TNKS, XDH 2.71635
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, ESR1, HSD17B2, MMP2, MMP9, PPARD, PTGS2, SRC, TOP2A 2.71018
[BP] GO:0001101 response to acid chemical AKR1B1, DNMT1, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC 2.69323
[BP] GO:0003018 None ADORA1, ADORA2A, EPHX2, PPARD, PTGS2, SRC 2.69021
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.69021
[BP] GO:0031401 positive regulation of protein modification process ADORA1, APP, BCL2, CDC25B, DNMT1, DYRK1A, FLT3, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.69021
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CYP1A1, PIM1, TERT, TNKS, TOP2A 2.66779
[BP] GO:0031347 regulation of defense response ADORA1, ADORA2A, CYP19A1, ESR1, FABP4, MMP12, MMP2, PPARA, PPARD, PTGS2, PTPN1, SRC 2.66779
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADORA2A, APP, BCL2, CDC25B, FABP4, FLT3, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.63502
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MMP9, PTGS2, PTPN1, SRC 2.62867
[BP] GO:0006954 inflammatory response ADORA1, ADORA2A, ADORA3, AXL, EPHX2, PIK3CA, PIK3CB, PTGS1, PTGS2 2.61696
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.61696
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.61696
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process ADORA2A, APP, AURKB, DNMT1, ESR1, IGF1R, MET, MMP12, PHF8, PPARA, PPARD, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A 2.60373
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 2.59489
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, EPHX2, ESR1, FABP3, FABP4, MET, PIK3CA, PIK3CB 2.581
[BP] GO:0042752 None ADORA1, ADORA2A, PPARA, RORC, TOP2A 2.57954
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 2.57918
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, APP, BCL2, CDC25B, FLT3, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.57918
[BP] GO:0044267 cellular protein metabolic process ADORA2A, ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, ESR1, FLT3, FUT7, IGF1R, KDR, MET, MMP1, MMP2, PHF8, PIK3CA, PIM1, PTPN1, SRC, TNKS, TNKS2, TOP2A 2.57918
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADORA2A, APP, BCL2, CDC25B, FABP3, FABP4, FLT3, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 2.56538
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.55756
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADORA2A, APP, BCL2, CDC25B, FABP3, FABP4, FLT3, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 2.525
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EPHX2 2.51324
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA2A, ADORA3, APP, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, FABP4, FLT3, IGF1R, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, TNKS, XDH 2.50359
[BP] GO:0031348 negative regulation of defense response ADORA1, ADORA2A, CYP19A1, MMP12, PPARA, PPARD 2.50015
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, CDK6, KDR, PIK3CB, SRC 2.50015
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, IGF1R, PPARA, PTGS2, SRC 2.50015
[BP] GO:0010605 negative regulation of macromolecule metabolic process ADORA2A, APEX1, APP, AURKB, CSNK2A1, DNMT1, DYRK1A, ESR1, FABP4, IGF1R, KDR, MMP12, MMP9, PPARA, PPARD, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 2.50015
[BP] GO:0051172 None ADORA2A, APEX1, APP, AURKB, CSNK2A1, DNMT1, DYRK1A, ESR1, FABP4, IGF1R, MMP12, MMP9, PPARA, PPARD, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 2.49343
[BP] GO:0002793 None ACHE, ADORA1, ADORA2A, HCAR2, MMP12, PPARD, SRC 2.49251
[BP] GO:0071456 cellular response to hypoxia BCL2, PPARD, PTGS2, SRC, TERT 2.48875
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 2.48875
[BP] GO:0031399 regulation of protein modification process ADORA1, ADORA2A, APP, BCL2, CDC25B, DNMT1, DYRK1A, FABP4, FLT3, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.48511
[BP] GO:1900673 olefin metabolic process CYP1A1, EPHX2 2.47199
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.47199
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, PIM1, PPARA, PPARD, RORC, SRC 2.47052
[BP] GO:0031328 positive regulation of cellular biosynthetic process ADORA2A, APP, AURKB, ESR1, FABP3, IGF1R, MET, MMP12, PHF8, PPARA, PPARD, PTGS2, RORC, SRC, TERT, TNKS, TNKS2, TOP2A 2.47021
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.47021
[BP] GO:0050789 regulation of biological process ABCB1, ACHE, ADORA1, ADORA2A, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA7, CA9, CDC25B, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, DYRK1A, EPHX2, ESR1, FABP3, FABP4, FLT3, GLO1, HCAR2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 2.46759
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, GLO1, MMP9, RORC 2.45353
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.44998
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, APP, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, ESR1, FLT3, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.44068
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, APP, BCL2, CDC25B, FLT3, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.43826
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, PPARA, PPARD 2.43308
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 2.42795
[BP] GO:0030336 None ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, PPARD 2.42543
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA2A, ADORA3, APP, AXL, BCL2, CA2, CDK6, CHRM2, CYP1B1, ESR1, HCAR2, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PPARD, PTGS2, SRC, TERT, TNKS2, XDH 2.41705
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA2A, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC, TNKS, TNKS2 2.41591
[BP] GO:2000117 negative regulation of cysteine-type endopeptidase activity ADORA2A, CSNK2A1, MMP9, PTGS2, SRC 2.4142
[BP] GO:0030154 cell differentiation ALPL, AXL, BCL2, CBR1, CDK6, CYP1A1, ESR1, FABP4, FLT3, FUT7, GLO1, KDR, MMP2, MMP9, PPARD, PTGS2, RORC, TOP2A 2.4142
[BP] GO:0035588 None ADORA1, ADORA2A, ADORA3 2.40262
[BP] GO:0036294 cellular response to decreased oxygen levels BCL2, PPARD, PTGS2, SRC, TERT 2.40077
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, ESR1, HSD17B2, PPARD, PTGS2, SRC 2.37899
[BP] GO:1901215 negative regulation of neuron death ADORA2A, AXL, BCL2, PIK3CA, PPARA, TERT 2.35862
[BP] GO:0051338 regulation of transferase activity ADORA1, ADORA2A, APP, AURKB, CDC25B, FABP4, FLT3, IGF1R, PIK3CA, PIK3CB, PTPN1, SRC, TNKS 2.34542
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.34542
[BP] GO:0051726 regulation of cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, PIM1, PTGS2, SRC, TERT, TNKS, TOP2A 2.34542
[BP] GO:0043065 positive regulation of apoptotic process ADORA2A, BCL2, CYP1B1, HCAR2, MMP9, PIK3CB, PTGS2, SRC, TOP2A, XDH 2.33896
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, ADORA2A, CYP19A1, PPARA, PPARD 2.33869
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 2.33544
[BP] GO:0051130 positive regulation of cellular component organization APP, AURKB, AXL, BCL2, DNMT1, ESR1, IGF1R, KDR, MET, MMP1, MMP9, SRC, TNKS, TNKS2 2.3325
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CYP1A1, CYP1A2, PPARD, PTGS2, SRC 2.3325
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, MET, SRC, TNKS, TOP2A 2.32684
[BP] GO:0043068 positive regulation of programmed cell death ADORA2A, BCL2, CYP1B1, HCAR2, MMP9, PIK3CB, PTGS2, SRC, TOP2A, XDH 2.31449
[BP] GO:2000146 None ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, PPARD 2.31
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.31
[BP] GO:0051047 None ACHE, ADORA1, ADORA2A, CYP19A1, HCAR2, MMP12, PPARD, SRC 2.30513
[BP] GO:0060969 None ESR1, PHF8, TERT 2.30463
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.30463
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.29024
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.29024
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA2A, ADORA3, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DNMT1, DYRK1A, ESR1, FABP3, FABP4, FLT3, GLO1, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 2.29024
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.29024
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.27716
[BP] GO:0050727 regulation of inflammatory response ADORA1, ADORA2A, CYP19A1, ESR1, FABP4, PPARA, PPARD, PTGS2 2.27162
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.25874
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.25874
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.25322
[BP] GO:0070213 None TNKS, TNKS2 2.25322
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.25322
[BP] GO:0002682 regulation of immune system process ADORA1, ADORA2A, APP, AXL, BCL2, CA2, CDK6, CYP19A1, ESR1, HCAR2, MMP12, MMP2, PIK3CA, PIK3CB, PTPN1, SRC 2.24544
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PTGS2, SRC 2.23829
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, APP, BCL2, CDC25B, DNMT1, DYRK1A, ESR1, FLT3, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.23829
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, DNMT1, IGF1R, MMP2, PTGS2, SRC 2.23135
[BP] GO:0051881 regulation of mitochondrial membrane potential ADORA2A, BCL2, KDR, SRC 2.23135
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.23135
[BP] GO:0097746 None ADORA1, ADORA2A, EPHX2, PPARD, PTGS2 2.23022
[BP] GO:0035296 None ADORA1, ADORA2A, EPHX2, PPARD, PTGS2 2.23022
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.21946
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC 2.21657
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.21213
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, ADORA2A, APP, BCL2, HCAR2, MMP12, PPARD, PTGS2, SRC 2.20843
[BP] GO:0051271 None ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, PPARD 2.20361
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CYP1A1, CYP1A2, PPARD, PTGS2, SRC 2.20361
[BP] GO:0071453 cellular response to oxygen levels BCL2, PPARD, PTGS2, SRC, TERT 2.19302
[BP] GO:0003013 None ADORA1, ADORA2A, EPHX2, PPARD, PTGS2, SRC 2.19302
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AURKB, BACE1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EPHX2, FABP3, FABP4, FUT7, PPARD, XDH 2.18418
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process ADORA2A, CSNK2A1, MMP9, PTGS2, SRC, XDH 2.18418
[BP] GO:0040014 regulation of multicellular organism growth APP, BCL2, PIK3CA, TNKS2 2.17464
[BP] GO:0032101 regulation of response to external stimulus ADORA1, ADORA2A, CYP19A1, ESR1, FABP4, KDR, MET, MMP12, PPARA, PPARD, PTGS2 2.16664
[BP] GO:0033044 None AURKB, DNMT1, PHF8, SRC, TNKS, TNKS2, TOP2A 2.16224
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, PPARA, PPARD, RORC, SRC 2.15836
[BP] GO:0010468 regulation of gene expression ADORA2A, ADORA3, APEX1, APP, AURKB, BCL2, CA9, CDK6, CSNK2A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, EPHX2, ESR1, FABP4, GLO1, KDR, MET, MMP12, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, RORC, SRC, TERT, TNKS, TOP2A, XDH 2.14868
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EPHX2 2.1476
[BP] GO:0045859 regulation of protein kinase activity ADORA1, ADORA2A, APP, CDC25B, FABP4, FLT3, IGF1R, PIK3CA, PIK3CB, PTPN1, SRC 2.14754
[BP] GO:0044093 positive regulation of molecular function ABCB1, ADORA1, APP, AURKB, BCL2, CDC25B, ESR1, FLT3, MET, MMP9, PIK3CA, PIK3CB, PTPN1, SRC, TERT, TNKS, XDH 2.14754
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.14605
[BP] GO:0051896 regulation of protein kinase B signaling AXL, MET, PIK3CA, PIK3CB, SRC, XDH 2.14605
[BP] GO:2001234 negative regulation of apoptotic signaling pathway BCL2, MMP9, PTGS2, PTPN1, SRC, TERT 2.14605
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1 2.14232
[BP] GO:0050880 None ADORA1, ADORA2A, EPHX2, PPARD, PTGS2 2.13916
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, DNMT1, IGF1R, SRC, TNKS, TNKS2 2.12889
[BP] GO:0035150 None ADORA1, ADORA2A, EPHX2, PPARD, PTGS2 2.12881
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.12881
[BP] GO:1901992 positive regulation of mitotic cell cycle phase transition APEX1, APP, CYP1A1, TERT 2.12684
[BP] GO:0010942 positive regulation of cell death ADORA2A, BCL2, CYP1B1, HCAR2, MMP9, PIK3CB, PTGS2, SRC, TOP2A, XDH 2.12684
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.12399
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.11179
[BP] GO:0007165 signal transduction ADORA1, ADORA2A, ADORA3, AKR1B1, APP, AXL, BCL2, CA1, CA2, CDK6, CHRM2, CSNK2A1, CYP1B1, DNMT1, ESR1, FLT3, HCAR2, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PTPN1, RORC, SRC, TNKS, TNKS2 2.10116
[BP] GO:0006807 nitrogen compound metabolic process ACHE, ADORA2A, AKR1B1, AKR1B10, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, DYRK1A, ESR1, FLT3, FUT7, GLO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIK3CA, PIM1, PPARA, PPARD, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 2.10116
[BP] GO:0051128 regulation of cellular component organization APP, AURKB, AXL, BCL2, CSNK2A1, DNMT1, ESR1, IGF1R, KDR, MET, MMP1, MMP9, PHF8, PIK3CB, PPARD, PTPN1, SRC, TNKS, TNKS2, TOP2A 2.09165
[BP] GO:0043207 response to external biotic stimulus ALPL, AXL, BCL2, CDK6, CHRM2, CYP1A1, CYP1A2, MMP12, PPARD, PTGS2, SRC 2.0847
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, FLT3, PTGS2, SRC 2.08223
[BP] GO:0035587 None ADORA1, ADORA2A, ADORA3 2.07649
[BP] GO:0033032 regulation of myeloid cell apoptotic process BCL2, HCAR2, PIK3CB 2.07649
[BP] GO:0043524 negative regulation of neuron apoptotic process ADORA2A, AXL, BCL2, PIK3CA, TERT 2.07649
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.07649
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA2A, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA7, CA9, CDC25B, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2D6, DNMT1, DYRK1A, ESR1, FABP3, FABP4, FLT3, GLO1, HCAR2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 2.07649
[BP] GO:0090087 None ACHE, ADORA1, ADORA2A, APP, CA2, HCAR2, MMP12, PPARD, PTGS2, PTPN1, SRC 2.07589
[BP] GO:0001775 cell activation ADORA2A, ALOX5, APP, AXL, BCL2, FLT3, FUT7, MMP9, PIK3CA, PIK3CB, RORC, SRC 2.0679
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, APP, DNMT1, IGF1R, MMP2, PTGS2, SRC 2.06635
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CYP1A1, PPARD, PTGS2, SRC, TYR 2.03991
[BP] GO:0033280 response to vitamin D ALPL, PTGS2, TYR 2.03991
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, APP, DNMT1, ESR1, FLT3, IGF1R, MMP2, PTGS2, SRC 2.03975
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, DYRK1A, ESR1, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TERT, XDH 2.02956
[BP] GO:0010639 None DNMT1, MET, PHF8, SRC, TNKS, TNKS2, TOP2A 2.02806
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, DYRK1A, ESR1, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TERT, XDH 2.02025
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, APP, CDC25B, CYP1A1, TERT 2.00698
[BP] GO:0032845 None ADORA1, BCL2, SRC, TNKS, TNKS2 2.00698
[BP] GO:0035265 organ growth BCL2, CYP19A1, ESR1 2.0061
[BP] GO:0010631 epithelial cell migration CYP1B1, KDR, PIK3CA, PPARD 2.00595
[CC] GO:0043227 membrane-bounded organelle ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CBR1, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, DYRK1A, EPHX2, ESR1, FABP3, FABP4, FLT3, FUT7, GLO1, IGF1R, KDR, MMP12, MMP2, MMP9, NQO2, PHF8, PIK3CB, PIM1, PPARA, PPARD, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 3.17075
[CC] GO:0043226 organelle ABCB1, ACHE, ADORA1, ADORA2A, AKR1B1, AKR1B10, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA9, CBR1, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, DYRK1A, EPHX2, ESR1, FABP3, FABP4, FLT3, FUT7, GLO1, IGF1R, KDR, MMP12, MMP2, MMP9, NQO2, PHF8, PIK3CB, PIM1, PPARA, PPARD, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 2.61025
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA1, ADORA2A, ADORA3, ALOX5, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, FLT3, FUT7, GLO1, HCAR2, HSD17B2, IGF1R, KDR, MET, MMP2, PHF8, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, TYR 2.48764
[CC] GO:0043231 intracellular membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, APEX1, APP, AURKB, BACE1, BCL2, CA4, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, DYRK1A, EPHX2, ESR1, FABP4, FLT3, FUT7, GLO1, IGF1R, KDR, MMP12, MMP2, PHF8, PIK3CB, PIM1, PPARA, PPARD, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 2.47199
[CC] GO:0099056 None ADORA1, ADORA2A 2.47199
[CC] GO:0098889 None ADORA1, ADORA2A 2.47199
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APEX1, APP, AURKB, BACE1, BCL2, CA1, CA2, CA4, CA7, CBR1, CDC25B, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EPHX2, ESR1, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, KDR, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 2.20843
[CC] GO:0005783 None ADORA1, APEX1, APP, BCL2, CA4, CYP19A1, CYP2D6, FLT3, KDR, PTGS2, PTPN1, XDH 2.12356
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA1, ADORA2A, ADORA3, ALPL, APP, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CHRM2, CSNK2A1, ESR1, FLT3, GLO1, HCAR2, IGF1R, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTPN1, SRC, TERT 2.07649
[MF] GO:0046914 transition metal ion binding ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, ESR1, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PHF8, PIM1, PPARA, PPARD, PTPN1, RORC, TNKS, TYR, XDH 14.9226
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, DYRK1A, EPHX2, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PHF8, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 14.1917
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX5, ALPL, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, DYRK1A, EPHX2, ESR1, FABP3, FABP4, FLT3, GLO1, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 12.5969
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.82778
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, DNMT1, ESR1, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PHF8, PPARA, PPARD, PTPN1, RORC, TNKS 8.32277
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, EPHX2, ESR1, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PHF8, PIM1, PPARA, PPARD, PTGS1, PTGS2, PTPN1, RORC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 7.85737
[MF] GO:0046872 metal ion binding ALOX5, ALPL, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, EPHX2, ESR1, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PHF8, PIM1, PPARA, PPARD, PTGS1, PTGS2, PTPN1, RORC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 7.51166
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HSD17B1, HSD17B2, NQO2, PHF8, PTGS1, PTGS2, TYR, XDH 7.35477
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.86673
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DYRK1A, FLT3, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, SRC, TOP2A 6.61027
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.35099
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PHF8, PTGS1, PTGS2, TYR 5.8046
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 5.28866
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2, SRC 5.25745
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1 5.24852
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 5.03786
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2, SRC 5.03114
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PHF8, XDH 4.601
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 3.98324
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HSD17B1, NQO2, PTGS1, PTGS2, SRC, XDH 3.73717
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR 3.71061
[MF] GO:0001609 None ADORA1, ADORA2A, ADORA3 3.60326
[MF] GO:0042802 identical protein binding ACHE, ADORA2A, APP, BCL2, CSNK2A1, DYRK1A, EPHX2, ESR1, FLT3, IGF1R, KDR, MET, MMP9, NQO2, PTGS2, TERT, TOP2A, TYR, XDH 3.3742
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.37122
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, MET, PIK3CA, PIM1, SRC 3.3333
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC 3.28625
[MF] GO:0004713 protein tyrosine kinase activity AXL, DYRK1A, FLT3, IGF1R, KDR, MET, SRC 3.27171
[MF] GO:0036094 small molecule binding ABCB1, ADORA1, AURKB, AXL, CDK6, CSNK2A1, DNMT1, DYRK1A, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARD, SRC, TOP2A, XDH 3.076
[MF] GO:0043560 insulin receptor substrate binding IGF1R, PIK3CA, PIK3CB 3.05427
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2, XDH 2.95417
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.95049
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC 2.95049
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC, TERT 2.87492
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.8458
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, PPARA, PPARD, RORC 2.56538
[MF] GO:0004879 nuclear receptor activity ESR1, PPARA, PPARD, RORC 2.56538
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC 2.44212
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, NQO2, XDH 2.43924
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.40262
[MF] GO:0003707 steroid hormone receptor activity ESR1, PPARA, PPARD, RORC 2.3325
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2 2.29024
[MF] GO:0035586 None ADORA1, ADORA2A, ADORA3 2.1806
[MF] GO:0000166 nucleotide binding ABCB1, AURKB, AXL, CDK6, CSNK2A1, DNMT1, DYRK1A, FLT3, HSD17B1, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, SRC, TOP2A, XDH 2.16228
[MF] GO:1901265 nucleoside phosphate binding ABCB1, AURKB, AXL, CDK6, CSNK2A1, DNMT1, DYRK1A, FLT3, HSD17B1, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, SRC, TOP2A, XDH 2.16224
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SRC 2.13688
[MF] GO:0005504 None FABP3, FABP4, PPARD 2.11179
[MF] GO:0046983 protein dimerization activity ACHE, ADORA1, ADORA2A, AXL, BCL2, EPHX2, FLT3, NQO2, PPARD, PTGS2, TERT, TOP2A, TYR, XDH 2.10287
[MF] GO:1901363 heterocyclic compound binding ABCB1, ADORA1, APEX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, DYRK1A, ESR1, FLT3, HSD17B1, IGF1R, KDR, MET, MMP12, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A, XDH 2.0847
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, BACE1, CDC25B, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIK3CA, PIM1, PTPN1, SRC 2.02844
[MF] GO:0043168 anion binding ABCB1, APP, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARD, SRC, TOP2A, XDH 2.02177


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 9.3102
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.9038
Pathways in cancer_Homo sapiens_hsa05200 CDK6, PIK3CA, FLT3, MMP1, MMP2, BCL2, PIK3CB, PTGS2, MMP9, MET, IGF1R, PPARD 6.4082
MicroRNAs in cancer_Homo sapiens_hsa05206 DNMT1, CDK6, ABCB1, PIK3CA, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B 6.5491
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, IGF1R 6.0048
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, ADORA1, PIK3CB, PTGS2, PTGS1 6.0048
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 5.9784
Metabolic pathways_Homo sapiens_hsa01100 CBR1, DNMT1, EPHX2, AKR1B1, PTGS2, TYR, CYP19A1, PTGS1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH 4.8551
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1 4.6934
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB, PPARD 4.6231
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 4.519
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, EPHX2, PTGS2, PTGS1 4.519
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, ADORA2A, PIK3CA, ADORA1, PIK3CB, PPARA 4.288
Melanoma_Homo sapiens_hsa05218 CDK6, PIK3CA, PIK3CB, MET, IGF1R 4.2927
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, BCL2, PIK3CB, MET, IGF1R 4.277
Rap1 signaling pathway_Homo sapiens_hsa04015 ADORA2A, PIK3CA, SRC, KDR, PIK3CB, MET, IGF1R 4.1766
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP2D6, CYP1A2, CYP1A1, CYP1B1 4.288
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA, PPARD 4.3221
Hepatitis B_Homo sapiens_hsa05161 CDK6, PIK3CA, SRC, BCL2, PIK3CB, MMP9 4.0947
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.288
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CDK6, PIK3CA, KDR, BCL2, PIK3CB, MET, IGF1R 3.8425
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, BCL2, PIM1, PIK3CB 3.7951
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, PIK3CA, BCL2, PIK3CB, PTGS2 4.0947
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, PIK3CA, BCL2, PIK3CB 3.6146
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP1A2, CYP1A1, CYP1B1, PTGS2 4.139
Serotonergic synapse_Homo sapiens_hsa04726 APP, CYP2D6, ALOX5, PTGS2, PTGS1 3.6124
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, BCL2, ADORA1, PIK3CB 3.4849
Glioma_Homo sapiens_hsa05214 CDK6, PIK3CA, PIK3CB, IGF1R 3.3973
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.0947
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1 3.2524
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET 3.3604
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB, IGF1R 2.9363
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 2.8011
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 3.1444
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, BCL2, PIK3CB, IGF1R 2.731
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.6457
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, PIK3CB, PPARA 2.6494
Ras signaling pathway_Homo sapiens_hsa04014 PIK3CA, KDR, PIK3CB, MET, IGF1R 2.4126
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.5194
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB 2.5634
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1 2.5634
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.5634
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1, PIK3CA, PIK3CB 2.3735
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, PIK3CB 2.1963
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2 2.1963
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, ADORA1, PIK3CB 2.1174
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.024
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB 1.8831
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, PIK3CA, SRC, PIK3CB 1.8745
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6, PIK3CA, PIK3CB 2.2041
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6, PIK3CA, PIK3CB 2.4728
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, PIK3CA, SRC, PIK3CB 1.8162
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, PIK3CB 1.9144
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB, IGF1R 2.3422
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, PIK3CA, PIK3CB 2.3213
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PIK3CB 2.0281
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB, IGF1R 1.9562
Colorectal cancer_Homo sapiens_hsa05210 PIK3CA, BCL2, PIK3CB 2.3729
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.3213
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 1.9618
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.594
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, BCL2, PIK3CB 1.7242
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.8044
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB, IGF1R 1.6919
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB, IGF1R 1.6278
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.5914
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA 1.6278
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, ADORA2A, ADORA3, ADORA1 1.5305
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, PIK3CB 1.594
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 PIK3CA, PIK3CB, IGF1R 1.5805
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB, PPARA 1.5305
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PIK3CB 1.5436
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2305
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3215
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3314
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3415
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 1.3396
Alcoholism_Homo sapiens_hsa05034 ADORA2A 0.3289
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.0185
HTLV-I infection_Homo sapiens_hsa05166 PIK3CA, TERT, PIK3CB 1.042
Parkinson's disease_Homo sapiens_hsa05012 ADORA2A 0.3959
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9187
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 0.9363
Axon guidance_Homo sapiens_hsa04360 MET 0.4312
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1, PPARD 0.9108
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4394
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.9488
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, PIK3CB 0.9048
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, ADORA2A 0.7815
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.7857
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB 0.794
Vascular smooth muscle contraction_Homo sapiens_hsa04270 ADORA2A 0.4451
Alzheimer's disease_Homo sapiens_hsa05010 BACE1, APP 0.8193
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.9918
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 1.0989
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 1.1233
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB 1.1233
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.182
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.1696
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB 1.1093
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.1332
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.1093
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5038
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5038
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5141
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.5038
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5133
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.527
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.528
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.53
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.53
Gap junction_Homo sapiens_hsa04540 SRC 0.53
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.529
Peroxisome_Homo sapiens_hsa04146 EPHX2, XDH 1.2502
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.3433
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.3809
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.5879
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5859
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6007
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.3608
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.6029
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2 1.3608
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.3809
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2D6, CYP1A2 1.3741
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.4674
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6227
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.4073
Shigellosis_Homo sapiens_hsa05131 SRC 0.6227
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.6227
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6438
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB 1.5581
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4759
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, PIK3CB 1.5959
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.6313
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.7047
Malaria_Homo sapiens_hsa05144 MET 0.7172
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PIK3CA, PIK3CB 1.7324
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.7303
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.7354
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.7462
Cysteine and methionine metabolism_Homo sapiens_hsa00270 DNMT1 0.7406
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.9144
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.7812
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8745
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.8193
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7934
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8595
Base excision repair_Homo sapiens_hsa03410 APEX1 0.8374
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8791
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0979
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.9108
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.869
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.9048
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.1233
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.2484


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)