TCM Prescription: Feng Han Gan Mao Granules



Prescription Description
Prescription IDTCMF7009
Pinyin NameFeng Han Gan Mao Ke Li
Chinese Name风寒感冒颗粒
English NameFeng Han Gan Mao Granules
Function Description解表发汗, 疏风散寒。用于风寒感冒, 发热, 头痛, 恶寒, 无汗, 咳嗽, 鼻塞, 流清涕。
IndicationsCommon cold disorder, Common cold
Disease ICD-11 Category SA60 [Common cold disorder (TM1), 感冒 (TM1) ];
CA00 [Acute nasopharyngitis, 急性鼻咽炎 ];
Human Tissues Associated with IndicationLung, Blood
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1398 Ephedra sinica 麻黄 TCMH1398 ITSAM882-14
TCMH677 Pueraria lobata 葛根 TCMH677 ITSAJ4206-14
TCMH2722 Perilla frutescens var. arguta 紫苏叶 TCMH2722 ITSAF2620-14
TCMH562 Saposhnikovia divaricata 防风 TCMH562 ITSAE3225-14
TCMH761 Cinnamomum cassia 桂枝 TCMH761 GQ255631
TCMH118 Angelica dahurica 白芷 TCMH118 ITSAK3312-14
TCMH243 Pericarpium citri reticulatae 陈皮 TCMH243
TCMH1219 Semen armeniacae amarum 苦杏仁 TCMH1219
TCMH1080 Platycodon grandiflorum 桔梗 TCMH1080 ITSAJ4293-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH1059 Glycine max 姜 TCMH1059 ITSAJ4675-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT226 PDPK1 3-phosphoinositide dependent protein kinase-1 Kinase O15530
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT287 TAS2R31 Taste receptor type 2 member 31 GPCR P59538
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT601 F2 Thrombin Unclassified P00734
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1354 Streptococcus mutans UA159
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 14.3829
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 13.4389
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 10.038
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 8.98483
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FUT7, GBA2, MIF, PIM1, TYR, XDH 8.7199
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP12, PIM1, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 8.41635
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FLT3, HSD11B2, HSD17B2, SRC, TYR 8.37679
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, MIF 8.37679
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.58909
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, BCL2, CA3, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, HSD11B2, HSD17B2, IGF1R, SRC, TYR 6.21276
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, ESR1, F2, F3, FABP4, FLT3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KDR, MET, MIF, SRC, TNKS, TNKS2, XDH 6.08425
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, AXL, BCL2, CA2, CA3, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KDR, SRC, TYR 5.94512
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, F2, FABP4, FLT3, FUT7, GBA2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, PIM1, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 5.94512
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CDK6, CNR1, F2, KDR, MIF, SRC, TNKS, TNKS2 5.89116
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, HSD11B2, SRC, TYR 5.59009
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.46752
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 5.30911
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F2, F3, FLT3, KDR, MET, MIF, MMP12, PTPN1, SRC, TNKS, TNKS2, XDH 5.30911
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F2, F3, FLT3, KDR, MET, MIF, MMP12, PTPN1, SRC, TNKS, TNKS2, XDH 5.30323
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF 4.96739
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF 4.76802
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.75765
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CA3, CNR1, CNR2, CYP1A1, CYP1B1, KDR, SRC 4.75329
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.71187
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, ESR1, ESRRA, F2, F3, FLT3, IGF1R, KDR, MIF, MMP12, PIM1, SRC, XDH 4.71187
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.70904
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, CNR1, CNR2 4.66951
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 4.63296
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, SRC, TYR 4.56985
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, IGF1R, KDR, MET, MIF, PIM1, PTPN1, SRC, XDH 4.51295
[BP] GO:0042221 response to chemical AKR1B1, ALPL, AXL, BCL2, CA2, CA3, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KDR, SRC, TYR 4.3972
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.3097
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F2, F3, FLT3, IGF1R, KDR, MET, MIF, MMP12, PTPN1, SRC, TNKS, TNKS2, XDH 4.3037
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, F2, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD17B2, KDR, MET, MIF, PIM1, SRC, TNKS2, TYR 4.26653
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F2, F3, FLT3, IGF1R, KDR, MET, MIF, MMP12, PTPN1, SRC, TNKS, TNKS2, XDH 4.21532
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, IGF1R, KDR, MET, MIF, PIM1, PTPN1, SRC, XDH 4.07585
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CA3, CA9, CDK6, CNR1, CNR2, CYP1A1, CYP1B1, HSD11B2, KDR, SRC 4.00837
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, IGF1R, KDR, MIF, PIM1, PTPN1, SRC, XDH 3.94056
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, ESR1, F2, F3, FLT3, IGF1R, KDR, MIF, MMP12, PIM1 3.93084
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, F2, F3, FLT3, KDR, MET, MIF, MMP12, PTPN1, SRC, TNKS, TNKS2, XDH 3.91669
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF 3.80847
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FLT3, HSD11B2, SRC 3.69804
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 3.6752
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 3.65578
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.58674
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESRRA, F2, F3, FABP4, FLT3, KDR, MET, MIF, MMP12, PTPN1, SRC, TNKS, TNKS2, XDH 3.57229
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP4, FUT7, GBA2, MET, MIF 3.54111
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.54054
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.54054
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AXL, BCL2, CYP1B1, F2, F3, FLT3, KDR, MET, MIF, PTPN1, SRC, XDH 3.49587
[BP] GO:0010035 response to inorganic substance AKR1B1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, SRC 3.43777
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, IGF1R, KDR, MET, MIF, MMP12, PIM1, PTPN1, SRC, TNKS, TNKS2, XDH 3.4137
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CA3, CA6, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, F2, F3, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KDR, MIF, MMP12, PTPN1, SRC, TYR 3.39578
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MET, MIF, PIM1, PTPN1, SRC 3.32487
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.23357
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.21022
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP12, PIM1, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 3.17816
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, F2, FLT3, GBA2, HSD11B1, HSD17B2, KDR, PIM1, SRC, TYR 3.13904
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AXL, BCL2, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, F2, F3, FABP4, HSD11B2, HSD17B2, IGF1R, MET, MMP12, PIM1, SRC, TNKS2, TYR 3.12447
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.09352
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, F2, KDR, SRC 3.09352
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CNR1, CNR2, CYP19A1, ESR1, F2, F3, FABP4, KDR, MET, MIF, MMP12 3.0554
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC, TNKS 3.02175
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, ESR1, FLT3, MET, MIF, PIM1, SRC, TYR 3.02048
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MET, MIF, PIM1, PTPN1, SRC 2.96086
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F2, F3, FLT3, IGF1R, KDR, MET, MIF, PTPN1, SRC, XDH 2.95601
[BP] GO:0032845 None ADORA1, BCL2, MIF, SRC, TNKS, TNKS2 2.93793
[BP] GO:0080134 regulation of response to stress ADORA1, CDK6, CNR1, CNR2, CYP19A1, ESR1, F2, F3, FABP4, IGF1R, MET, MIF, MMP12, PTPN1, SRC, XDH 2.91571
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, CNR1, F2, TNKS, TNKS2 2.90336
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MIF, SRC 2.87655
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MIF 2.87469
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, F2, F3, FABP4, FLT3, IGF1R, KDR, MET, MIF, MMP12, PTPN1, SRC, TNKS, TNKS2, XDH 2.85632
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, BCL2, CDK6, CNR1, CNR2, CYP19A1, ESR1, ESR2, F2, IGF1R, MET, MIF, MMP12, PTPN1, SRC, XDH 2.84757
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FLT3, HSD11B2, IGF1R, SRC 2.84539
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.79738
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, FABP4, IGF1R, KDR, MET, MIF, MMP12, PIM1, PTPN1, SRC, TNKS, TNKS2, XDH 2.79738
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP4, FLT3, IGF1R, KDR, MET, MIF, MMP12, PIM1, PTPN1, SRC, TNKS, TNKS2, XDH 2.76158
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, FABP4, IGF1R, MET, PIM1, PTPN1, SRC, TNKS 2.76158
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MIF, PIM1, PTPN1, SRC 2.74721
[BP] GO:0009115 None AOX1, XDH 2.7449
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.72808
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP12, PIM1, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 2.67569
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MIF, SRC 2.60638
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 2.604
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, AURKB, AXL, BCL2, CA3, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, PTPN1, SRC, TNKS, XDH 2.6039
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MIF, SRC 2.60281
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.57645
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, SRC 2.56905
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP4, GBA2 2.51559
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.51559
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, AXL, BCL2, CA2, CA7, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1B1, F2, F3, IGF1R, KDR, MET, MIF, MMP12, PTPN1, SRC 2.51559
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MIF, SRC 2.49263
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.49035
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.47621
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, SRC 2.47309
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.46559
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.46258
[BP] GO:0032103 positive regulation of response to external stimulus CNR1, F2, F3, FABP4, KDR, MET, MIF 2.46258
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP4, FUT7, GBA2, MMP12, SRC, XDH 2.45241
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.4327
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.40902
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, AURKB, AXL, BCL2, CA3, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, PTPN1, SRC, TNKS, XDH 2.40902
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, IGF1R, KDR, MET, MIF, MMP12, PTPN1, SRC, TNKS, TNKS2, XDH 2.39357
[BP] GO:0046110 None AOX1, XDH 2.39357
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.39357
[BP] GO:0043207 response to external biotic stimulus ALPL, AXL, BCL2, CDK6, CNR1, CNR2, CYP1A1, CYP1A2, F2, MMP12, SRC 2.36981
[BP] GO:0002683 negative regulation of immune system process ADORA1, AXL, CDK6, CNR1, CNR2, CYP19A1, MIF, MMP12 2.34845
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.34595
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF 2.34595
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, SRC 2.34595
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, ESR1, F2, F3, FABP4, FLT3, IGF1R, MIF, PTPN1, SRC, TNKS, XDH 2.34548
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.32766
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, BCL2, CYP19A1, CYP1A1, CYP1B1, GBA2, TYR 2.31085
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC, TNKS 2.30478
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.26412
[BP] GO:0002682 regulation of immune system process ADORA1, AXL, BCL2, CA2, CDK6, CNR1, CNR2, CYP19A1, ESR1, ESRRA, F2, MIF, MMP12, PTPN1, SRC 2.25797
[BP] GO:0009607 response to biotic stimulus ALPL, AXL, BCL2, CDK6, CNR1, CNR2, CYP1A1, CYP1A2, F2, MMP12, SRC 2.23833
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.23573
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.21509
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, AXL, BCL2, CA12, CA2, CA7, CNR1, ESR1, F2, FABP4, FLT3, MET, SRC 2.2084
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, SRC 2.20428
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CNR1, CYP1A1, HSD11B2, SRC, TYR 2.20428
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.17108
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, FLT3, HSD11B2, SRC 2.16617
[BP] GO:0070213 None TNKS, TNKS2 2.16617
[BP] GO:0006145 None AOX1, XDH 2.16617
[BP] GO:0038171 None CNR1, CNR2 2.16617
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.16617
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, F2, FLT3, IGF1R, KDR, MET, SRC, TNKS 2.11486
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, AXL, BCL2, CDK6, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, SRC 2.11166
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, AXL, BCL2, CA2, CDK6, CNR1, CYP1B1, ESR1, ESRRA, ESRRB, F2, F3, KDR, MET, MIF, MMP12, PIM1, SRC, TNKS2, XDH 2.11166
[BP] GO:0009605 response to external stimulus ADORA1, ALPL, AXL, BCL2, CDK6, CNR1, CNR2, CYP1A1, CYP1A2, F2, HSD11B2, MMP12, SRC, TYR 2.107
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.09159
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, FABP4, IGF1R, KDR, MET, MIF, MMP12, PIM1, PTPN1, SRC, TNKS, TNKS2, XDH 2.06761
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.04618
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, ESR1, ESRRB, HSD17B2, SRC 2.02327
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, ESR2, F2, F3, FABP4, FLT3, IGF1R, MET, MIF, PIM1, PTPN1, SRC, TNKS, XDH 2.00752
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, AURKB, BCL2, CA1, CA2, CA3, CA4, CA5A, CA5B, CA7, CDC25B, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, F2, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KDR, MIF, PIM1, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 2.47847
[CC] GO:0044432 endoplasmic reticulum part BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, F2, FLT3, GBA2, HSD11B1, HSD11B2, HSD17B2, PTPN1 2.40165
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX5, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, F2, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B2, IGF1R, KDR, MET, PIM1, PTPN1, SRC, TNKS, TNKS2, TYR 2.01134
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, GBA2, HSD11B1, HSD11B2, HSD17B2 1.97557
[CC] GO:0097443 sorting endosome KDR, PTPN1 1.85732
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 20.6266
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, MMP12, PIM1, PTPN1, TNKS, TYR, XDH 15.2596
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 13.4389
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, F2, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP12, PIM1, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 13.4389
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 11.9763
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, MMP12, PIM1, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 8.37679
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 7.92629
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.72852
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP12, PTPN1, TNKS 6.63184
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 6.39189
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, XDH 5.93122
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, F2, MMP12, PIM1, PTPN1, TNKS, TNKS2, TYR, XDH 5.68338
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, F2, MMP12, PIM1, PTPN1, TNKS, TNKS2, TYR, XDH 5.30911
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 5.30911
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 5.28797
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 5.01851
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC 4.27507
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B2, HSD17B1, SRC, XDH 4.08472
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC 4.08472
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1 4.02387
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 4.0221
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 3.80847
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.42867
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.42079
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.33342
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.31939
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6 3.07512
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.99849
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.7449
[MF] GO:0003845 None HSD11B1, HSD11B2 2.7449
[MF] GO:0008389 None CYP2A13, CYP2A6 2.7449
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.72715
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.7117
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, IGF1R, KDR, MET 2.6615
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB 2.57558
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB 2.57558
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CDK6, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, IGF1R, KDR, MET 2.53261
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.50325
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.49035
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.40323
[MF] GO:0004949 None CNR1, CNR2 2.39357
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB 2.34595
[MF] GO:0008289 lipid binding AXL, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP4, HSD11B2, HSD17B1 2.31612
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, IGF1R, KDR, MET 2.20161
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.16617


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA3, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 22.0818
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 9.4306
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.2982
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 5.6385
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, TYR, GBA2, CYP19A1, HSD11B1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 5.1818
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 5.4311
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.3963
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 4.1
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1 3.2999
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, BCL2, PIM1, CYP1B1, MET, CDC25B 2.6107
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, KDR, MET, ESR1, IGF1R 2.5355
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, IGF1R 2.5355
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, CNR1, KDR, MET, IGF1R 2.4885
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, MIF, TYR 2.7742
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CNR2, CNR1, ADORA3, ADORA1, F2 2.0593
Melanoma_Homo sapiens_hsa05218 CDK6, MET, IGF1R 2.062
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.062
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2, AOX1 2.0643
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, KDR, BCL2, MET, IGF1R 1.7484
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 BCL2, PIM1, F3 1.7484
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, ESR1, ESR2 1.7484
Pathways in cancer_Homo sapiens_hsa05200 CDK6, FLT3, BCL2, MET, IGF1R 1.5577
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.514
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.6085
Hepatitis B_Homo sapiens_hsa05161 CDK6, SRC, BCL2 1.4345
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.3555
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.2994
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MET, IGF1R 1.2789
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.3497
Glioma_Homo sapiens_hsa05214 CDK6, IGF1R 1.2789
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3479
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.1001
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.3166
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.332
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.2745
Prostate cancer_Homo sapiens_hsa05215 BCL2, IGF1R 1.106
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.0571
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.2745
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.9846
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2 0.9851
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2 1.1237
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.4728
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1823
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 1.0267
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7392
Complement and coagulation cascades_Homo sapiens_hsa04610 F2, F3 1.1822
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.0897
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.618
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.9626
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 0.9626
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 0.8841
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8894
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.8661
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.9473
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8748
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7016
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.7838
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.6737
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.7457
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC 0.6694
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, F2 0.66
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2745
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3863
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3636
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3763
cAMP signaling pathway_Homo sapiens_hsa04024 ADORA1 0.347
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3636
Apoptosis_Homo sapiens_hsa04210 BCL2 0.4362
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.4054
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.4242
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.4362
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.435
Platelet activation_Homo sapiens_hsa04611 SRC 0.4641
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.4467
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.4641
Insulin resistance_Homo sapiens_hsa04931 PTPN1 0.4911
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4641
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.4641
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.5289
Axon guidance_Homo sapiens_hsa04360 MET 0.4593
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5 0.4852
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5153
GnRH signaling pathway_Homo sapiens_hsa04912 SRC 0.5289
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5181
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5217
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5289
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5289
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5217
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1 0.5153
Gap junction_Homo sapiens_hsa04540 SRC 0.5289
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5289
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5217
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5289
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.5724
Peroxisome_Homo sapiens_hsa04146 XDH 0.5322
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5719
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5921
Pancreatic cancer_Homo sapiens_hsa05212 CDK6 0.5921
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5929
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5921
Bile secretion_Homo sapiens_hsa04976 CA2 0.5784
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5921
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5845
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.5921
PPAR signaling pathway_Homo sapiens_hsa03320 FABP4 0.5845
Shigellosis_Homo sapiens_hsa05131 SRC 0.5921
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6 0.6149
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5 0.5921
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.66
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6469
Malaria_Homo sapiens_hsa05144 MET 0.6574
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.66
Bladder cancer_Homo sapiens_hsa05219 SRC 0.6878
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.66
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2 0.702
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7838
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.7981
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7981
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8228
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8142
Phenylalanine metabolism_Homo sapiens_hsa00360 MIF 0.9566
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.9473
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9978
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2745


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)