TCM Prescription: Yang Xin An Shen Pills



Prescription Description
Prescription IDTCMF6845
Pinyin NameYang Xin An Shen Wan
Chinese Name养心安神丸
English NameYang Xin An Shen Pills
Function Description不寐, 眩晕, 心悸, 耳鸣, 健忘
IndicationsTinnitus disorder, Vertigo disorder, Forgetfulness disorder, Insomnia disorder, Insomnia, Tinnitus, Palpitations, Dizziness
Disease ICD-11 Category SC75 [Tinnitus disorder (TM1), 耳鸣 (TM1) ];
SD22 [Vertigo disorder (TM1), 眩晕 (TM1) ];
SD23 [Forgetfulness disorder (TM1), 健忘 (TM1) ];
SD84 [Insomnia disorder (TM1), 不寐 (TM1) ];
7A0Z [Insomnia disorders, unspecified, 失眠障碍，未特指的 ];
MC41 [Tinnitus, 耳鸣 ];
MC81.2 [Palpitations, 心悸 ];
MB48 [Dizziness and giddiness, 头晕和眩晕 ];
Human Tissues Associated with IndicationHeart, Brain
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2202 Schisandra chinensis 五味子 TCMH2202 ITSAM2867-14
TCMH1963 Caulis polygoni multiflori 首乌藤 TCMH1963
TCMH815 Flos albiziae 合欢花 TCMH815
TCMH967 Polygonatum sibiricum 黄精 TCMH967 ITSAH4762-14
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH407 Salvia miltiorrhiza 丹参 TCMH407 ITSAH2408-14
TCMH2052 Ziziphus jujuba var. spinosa 酸枣仁 TCMH2052 ITSAM943-14
TCMH2554 Polygala tenuifolia 远志 TCMH2554 MF096619
TCMH2624 Anemarrhena asphodeloides 知母 TCMH2624 GBVA3255-11, GBVU1201-13
TCMH324 Magnetitum 磁石 TCMH324
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT186 MAOB Monoamine oxidase B Oxidoreductase P27338
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT211 CES1 Acyl coenzyme A:cholesterol acyltransferase Transferase P23141
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT39 PDE5A Phosphodiesterase 5A Hydrolase O76074
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT633 SLC6A4 Serotonin transporter Transporter P31645
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1168 Trichomonas vaginalis
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1405 Penicillium citrinum
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, FABP3, HMGCR, PDE5A, PIM1, PPARA, TYR, XDH 12.4537
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.9795
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.0089
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, ESR1, FABP3, FABP4, HMGCR, HSD11B1, HSD17B2, MET, PPARA, TRPV1 10.8136
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CES1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP3A4, ESR1, HMGCR, HSD11B1, HSD17B2 9.84125
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HMGCR, HSD11B1, HSD17B2, IGF1R, KCNH2, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PDE5A, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TRPV1, TYR, XDH 9.40465
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX12, ALOX15, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19 8.89178
[BP] GO:0042221 response to chemical ADRA2A, AKR1B1, ALOX15, AXL, CA2, CA9, CES1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HMGCR, HSD17B2, IGF1R, KCNH2, KDR, MAOB, MMP2, MMP9, NR3C1, PPARA, RORC, SLC6A2, SLC6A4, SRC, TERT, TRPV1, TYR 8.62849
[BP] GO:0006690 icosanoid metabolic process ALOX12, ALOX15, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19 8.62849
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 8.17244
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, HMGCR, HSD11B1, HSD17B2, MAOB, TYR, XDH 8.03952
[BP] GO:0019369 arachidonic acid metabolic process ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19 8.00046
[BP] GO:0006631 fatty acid metabolic process ALOX12, ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FABP3, PPARA 7.76908
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19 7.27573
[BP] GO:0010033 response to organic substance ADRA2A, AKR1B1, ALOX15, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HMGCR, HSD17B2, IGF1R, KDR, MAOB, MMP2, NR3C1, PPARA, RORC, SLC6A4, SRC, TRPV1, TYR 7.1357
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AXL, CA9, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, HMGCR, HSD17B2, IGF1R, MAOB, MMP2, MMP9, NR3C1, PPARA, RORC, SLC6A4, SRC, TRPV1, TYR 7.08225
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA2A, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CA2, CA7, CDC25B, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, HCAR2, HMGCR, IGF1R, KCNH2, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PDE5A, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TRPV1, XDH 7.08225
[BP] GO:1901568 fatty acid derivative metabolic process ALOX12, ALOX15, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19 7.08225
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HMGCR, HSD17B2, IGF1R, KCNH2, KDR, MAOB, MET, MMP1, MMP2, NR3C1, PDE5A, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TYR, XDH 7.02467
[BP] GO:0006805 xenobiotic metabolic process CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, CYP3A4, RORC 6.96018
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA2A, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, FABP3, FABP4, FLT3, HCAR2, HMGCR, HSD11B1, HSD17B2, KCNH2, KDR, MAOB, MET, PPARA, SLC6A2, SLC6A4, SRC, TERT, TRPV1, XDH 6.83023
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX12, ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, FABP3, FABP4, HMGCR, MET, PPARA 6.74859
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, TRPV1 6.14854
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA2A, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CA2, CA7, CDC25B, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HCAR2, HMGCR, IGF1R, KCNH2, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PDE5A, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TRPV1, XDH 6.10614
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19 6.07443
[BP] GO:0033993 response to lipid AXL, CA2, CA9, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD17B2, MAOB, NR3C1, RORC, SLC6A4, SRC, TYR 6.05991
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX12, CDC25B, CYP1B1, ESR1, ESRRA, FABP3, FLT3, HMGCR, IGF1R, KDR, MMP12, MMP2, MMP9, PDE5A, PIM1, SLC6A4, SRC, TERT, XDH 6.05808
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MAOB, MMP9, SRC, TERT 5.6986
[BP] GO:0009725 response to hormone ADRA2A, AKR1B1, CA2, CA9, CYP1A2, ESR1, ESRRA, FABP3, FLT3, MAOB, NR3C1, PPARA, SLC6A4, SRC, TRPV1 5.6986
[BP] GO:0032787 None ALOX12, ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FABP3, PPARA 5.52192
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PIM1, PPARA, RORC, SRC 5.48599
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, ALOX15, AXL, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KCNH2, KDR, MMP2, MMP9, NR3C1, RORC, SLC6A4, SRC, TERT, TRPV1 5.34413
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD17B2 5.29688
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA2A, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AXL, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, FABP4, HMGCR, HSD17B2, IGF1R, KCNH2, MET, MMP1, MMP12, MMP2, MMP9, PDE5A, PIM1, PPARA, RORC, SLC6A2, SLC6A4, SRC, TRPV1, TYR 5.29688
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, CES1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HMGCR, MAOB, TYR 5.27861
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC, SRC 5.27861
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADRA2A, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HCAR2, HMGCR, HSD11B1, HSD17B2 5.2718
[BP] GO:0014070 response to organic cyclic compound CA2, CA9, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, MAOB, NR3C1, RORC, SLC6A4, SRC, TRPV1, TYR 5.23695
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP3A4, FABP3, FABP4, MAOB, MMP1, MMP12, MMP2, MMP9, PDE5A, SRC, XDH 5.23695
[BP] GO:0042493 response to drug AKR1B1, AXL, CA9, CYP1A1, CYP1B1, FABP3, HMGCR, KCNH2, KDR, MAOB, NR3C1, SLC6A2, SLC6A4, SRC, TRPV1 5.1715
[BP] GO:0009719 response to endogenous stimulus ADRA2A, AKR1B1, CA2, CA9, CYP1A2, ESR1, ESRRA, FABP3, FLT3, IGF1R, MAOB, MMP2, NR3C1, PPARA, SLC6A4, SRC, TRPV1 5.13359
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 5.07815
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, TRPV1 4.98378
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP2C19, CYP3A4 4.72077
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CYP1B1, ESR1, FLT3, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, TRPV1, XDH 4.71331
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA2A, AKR1B1, ALOX15, AXL, CA2, CA7, CYP19A1, CYP1B1, FLT3, HCAR2, HMGCR, KDR, MET, MMP12, MMP9, PDE5A, PTPN1, SRC, TERT, XDH 4.68775
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA2A, AKR1B1, ALOX15, AXL, CA2, CA7, CYP19A1, CYP1B1, FLT3, HCAR2, HMGCR, KDR, MET, MMP12, MMP9, PDE5A, PTPN1, SRC, TERT, XDH 4.66228
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX12, ALOX15, CES1, CYP19A1, CYP3A4, HMGCR, TYR 4.63201
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B2 4.61048
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CYP1B1, ESR1, FLT3, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC, TERT, TRPV1, XDH 4.57205
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC, SRC 4.54848
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX15, AURKB, AXL, CA2, CA6, CA9, CES1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HMGCR, HSD17B2, IGF1R, KCNH2, KDR, MAOB, MMP12, MMP2, MMP9, NR3C1, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, SRC, TERT, TRPV1, TYR 4.54848
[BP] GO:0019752 carboxylic acid metabolic process ALOX12, ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FABP3, PIM1, PPARA, TYR 4.36624
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ADRA2A, ALOX12, ALOX15, AXL, CA2, CA7, CYP19A1, CYP1B1, HCAR2, HMGCR, IGF1R, KCNH2, KDR, MAOB, MET, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SRC, TERT, TRPV1 4.28571
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, HMGCR 4.20777
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CES1, CYP19A1, CYP3A4, HMGCR, HSD11B1, HSD17B2 4.1895
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX12, AURKB, AXL, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HMGCR, IGF1R, KCNH2, KDR, MAOB, MET, MMP12, MMP9, NR3C1, PDE5A, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TRPV1, XDH 4.16277
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HCAR2, HMGCR, IGF1R, KCNH2, KDR, MAOB, MET, MMP12, MMP9, NR3C1, PDE5A, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TRPV1, XDH 4.11481
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, ADRA2A, CYP1A1, FABP3, FLT3, HCAR2, HMGCR, PPARA, RORC, SRC 3.99448
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, CYP1B1, ESR1, FLT3, HCAR2, HMGCR, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, TERT, TRPV1, XDH 3.99448
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, ALOX15, AXL, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, NR3C1, RORC, SLC6A4, SRC, TRPV1 3.92981
[BP] GO:0043436 oxoacid metabolic process ALOX12, ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FABP3, PIM1, PPARA, TYR 3.87594
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TERT 3.86341
[BP] GO:0006082 organic acid metabolic process ALOX12, ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FABP3, PIM1, PPARA, TYR 3.78818
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 3.7577
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2C19, CYP3A4 3.7577
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, ALOX15, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KCNH2, KDR, MMP2, MMP9, NR3C1, PTPN1, RORC, SLC6A4, SRC, TERT, TRPV1 3.7577
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA2A, ALOX15, AURKB, CDC25B, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, HMGCR, IGF1R, KDR, MAOB, MET, MMP12, MMP9, NR3C1, PDE5A, PPARA, PTPN1, RORC, SRC, TERT, TRPV1, XDH 3.70939
[BP] GO:0009636 response to toxic substance AKR1B1, AXL, CES1, CYP1A1, CYP1B1, HMGCR, KDR, MAOB, SLC6A4, SRC 3.64111
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA2A, ALOX15, AURKB, CDC25B, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, HMGCR, IGF1R, KDR, MAOB, MET, MMP12, MMP9, NR3C1, PDE5A, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TRPV1, XDH 3.60677
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC, TERT 3.60677
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 3.57844
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1, MAOB 3.56787
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, AURKB, AXL, CDC25B, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HMGCR, HSD11B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PDE5A, PIM1, PPARA, PTPN1, RORC, SRC, TERT, TRPV1, TYR, XDH 3.56625
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.55831
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.55831
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, ALOX12, CDC25B, ESR1, FLT3, HMGCR, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, TERT 3.53886
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, AURKB, AXL, CDC25B, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HMGCR, HSD11B1, HSD17B2, IGF1R, KCNH2, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PDE5A, PIM1, PPARA, PTPN1, RORC, SRC, TERT, TRPV1, TYR, XDH 3.51331
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA2A, ALOX15, AURKB, CDC25B, ESR1, ESR2, ESRRA, ESRRB, FLT3, HMGCR, IGF1R, KDR, MAOB, MET, MMP12, MMP9, NR3C1, PDE5A, PPARA, PTPN1, RORC, SRC, TERT, TRPV1, XDH 3.49986
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP3A4, MAOB 3.49628
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4 3.45883
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, PPARA, SRC, TYR 3.45267
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B2 3.39984
[BP] GO:0050665 hydrogen peroxide biosynthetic process CYP1A1, CYP1A2, MAOB 3.3913
[BP] GO:0042592 homeostatic process ADORA1, ADRA2A, AKR1B1, ALOX12, AXL, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, KCNH2, MET, SRC, TERT, TRPV1 3.3753
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ADRA2A, ALOX15, AXL, CA2, CA7, CYP19A1, HCAR2, HMGCR, KCNH2, MAOB, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SRC, TERT, TRPV1 3.37462
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX12, ALOX15, CES1, CYP19A1, CYP1A1, CYP3A4, HMGCR, HSD11B1, HSD17B2 3.34047
[BP] GO:0042737 drug catabolic process ACHE, CYP1A2, CYP2A6, CYP2C19, CYP3A4, MAOB 3.33605
[BP] GO:0071407 cellular response to organic cyclic compound CYP1A1, CYP1B1, ESR1, FLT3, NR3C1, RORC, SLC6A4, SRC, TRPV1 3.27887
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 3.18223
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, CA2, CA9, CDC25B, CES1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FLT3, HMGCR, HSD11B1, HSD17B2, KDR, MAOB, MET, MMP2, MMP9, PIM1, PPARA, RORC, SLC6A4, SRC, TERT, TYR 3.11772
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA2A, AKR1B1, ALOX15, AXL, CYP1B1, FLT3, HMGCR, KDR, MET, PDE5A, PTPN1, SRC, XDH 3.11772
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADRA2A, AURKB, CA2, CA7, HCAR2, HMGCR, KDR, SRC, TRPV1 3.11043
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, KCNH2, KDR, NR3C1, SRC, TRPV1 3.06369
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, HMGCR, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, TERT 3.04402
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, KCNH2, PPARA, SLC6A2, SLC6A4, TRPV1 3.01394
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, TERT 3.00274
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 2.99485
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA2A, ALOX12, ALOX15, CYP19A1, ESR1, ESR2, HMGCR, IGF1R, MET, MMP12, MMP9, PPARA, PTPN1, SRC, TERT, XDH 2.93126
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CYP1B1, ESR1, IGF1R, MMP2, MMP9, NR3C1, RORC, SLC6A4, SRC, TRPV1 2.88603
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA2A, ALOX15, FLT3, HMGCR, KDR, PDE5A, PTPN1, SRC, XDH 2.87117
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA2A, AKR1B1, ALOX15, AXL, CYP1B1, FLT3, HMGCR, KDR, MET, MMP12, MMP9, PDE5A, PTPN1, SRC, TERT, XDH 2.83667
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA2A, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, HCAR2, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PDE5A, PTPN1, SLC6A4, SRC, TERT, XDH 2.82517
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ADRA2A, ALOX12, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, SRC, TERT 2.7898
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA2A, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, HCAR2, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PDE5A, PTPN1, SLC6A4, SRC, TERT, XDH 2.78037
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA2A, ALOX12, AXL, CA2, CYP1B1, ESRRB, HCAR2, HMGCR, KDR, MET, MMP12, MMP9, PDE5A, PIM1, SRC, TERT, TRPV1 2.78037
[BP] GO:0009115 None AOX1, XDH 2.78037
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 2.78037
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 2.78037
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 2.78037
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HCAR2, HMGCR, HSD17B2, IGF1R, KCNH2, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PDE5A, PIM1, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, SRC, TERT, TRPV1, TYR, XDH 2.7666
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA2A, ALOX15, AURKB, CDC25B, ESR1, ESR2, ESRRA, ESRRB, FLT3, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PDE5A, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, XDH 2.76324
[BP] GO:0010038 response to metal ion ALOX15, CA2, CYP1A1, CYP1A2, FABP4, MAOB, MMP9, TERT 2.74975
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA2A, ALOX12, AXL, CA2, CYP1B1, ESR1, ESRRA, ESRRB, HCAR2, HMGCR, KCNH2, KDR, MET, MMP12, MMP9, PDE5A, PIM1, SLC6A4, SRC, TERT, TRPV1, XDH 2.7478
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.72758
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA2A, ALOX15, CDC25B, ESRRB, FABP3, FLT3, HMGCR, KDR, MMP9, PDE5A, PTPN1, SRC, XDH 2.6254
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA2A, ALOX15, CDC25B, ESRRB, FABP3, FLT3, HMGCR, KDR, MMP9, PDE5A, PTPN1, SRC, XDH 2.6254
[BP] GO:0044283 None AKR1B1, ALOX12, ALOX15, ALOX5, CES1, CYP19A1, CYP1A1, CYP3A4, HMGCR 2.6254
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, MAOB, XDH 2.59245
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, ADRA2A, AXL, CA2, CYP19A1, HCAR2, KCNH2, MMP12, SLC6A4, SRC, TERT, TRPV1 2.58296
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ADRA2A, ALOX12, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, SRC, TERT 2.57747
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, ADRA2A, FLT3, HMGCR, IGF1R, PDE5A, PTPN1, SRC 2.57747
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.56944
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5 2.56944
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA2A, ESR1, ESR2, HMGCR, IGF1R, MET, MMP12, MMP9, PTPN1, SLC6A4, SRC, TERT, XDH 2.54061
[BP] GO:1901361 None AOX1, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP3A4, MAOB, PDE5A, XDH 2.53141
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA2A, ESR1, ESR2, HMGCR, IGF1R, MET, MMP12, MMP9, PTPN1, SLC6A4, SRC, TERT, XDH 2.52994
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA2A, AKR1B1, ALOX15, AXL, CYP1B1, ESRRA, FABP4, FLT3, HMGCR, KDR, MET, MMP12, MMP2, MMP9, PDE5A, PTPN1, SRC, TERT, XDH 2.51191
[BP] GO:0080134 regulation of response to stress ADORA1, ADRA2A, ALOX12, CYP19A1, ESR1, FABP4, HMGCR, IGF1R, MET, MMP12, MMP2, PPARA, PTPN1, SRC, TERT, XDH 2.50463
[BP] GO:0072593 reactive oxygen species metabolic process ALOX12, CYP1A1, CYP1A2, CYP1B1, MAOB 2.49762
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA2A, ALOX15, CDC25B, ESRRB, FLT3, HMGCR, KDR, MMP9, PDE5A, PTPN1, SRC, XDH 2.49762
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA2A, AKR1B1, ALOX15, AURKB, AXL, CYP1B1, ESR1, FLT3, HMGCR, IGF1R, KDR, MET, MMP9, PDE5A, PTPN1, SRC, XDH 2.48716
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, MMP2, PPARA, SLC6A4, SRC, TERT 2.45988
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA2A, ALOX15, FLT3, HMGCR, IGF1R, KDR, PDE5A, PTPN1, SRC, XDH 2.45143
[BP] GO:0050994 None ADORA1, ADRA2A, HCAR2, PPARA 2.44627
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, CA2, CYP1A1, HMGCR, MMP2, PPARA, SLC6A4, SRC, TERT, TRPV1, TYR 2.44615
[BP] GO:0044236 multicellular organism metabolic process MMP1, MMP12, MMP2, MMP9, TRPV1 2.43313
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRA2A, AURKB, CYP1B1, ESR1, FABP4, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC 2.41079
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.41079
[BP] GO:0046110 None AOX1, XDH 2.41079
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.41079
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, MMP2, PPARA, SLC6A4, SRC, TERT 2.41058
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA2A, ALOX15, CDC25B, ESRRB, FABP4, FLT3, HMGCR, IGF1R, KDR, MMP9, PDE5A, PPARA, PTPN1, SRC, XDH 2.40372
[BP] GO:0051046 None ACHE, ADORA1, ADRA2A, CYP19A1, HCAR2, HMGCR, MAOB, MMP12, SLC6A4, SRC, TRPV1 2.40327
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.34204
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ADRA2A, ALOX12, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, SRC, TERT 2.32517
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ADRA2A, ALOX12, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, SRC, TERT 2.31321
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.31194
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AOX1, AURKB, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP3A4, FABP3, FABP4, MAOB, PDE5A, SRC, XDH 2.30988
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, HCAR2, MMP12, SLC6A4, SRC, TRPV1 2.30988
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.29513
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, ALOX12, MET, TRPV1 2.26107
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AOX1, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, MAOB, PDE5A, XDH 2.25588
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA2A, ALOX15, CDC25B, ESRRB, FABP3, FABP4, FLT3, HMGCR, IGF1R, KDR, MMP9, PDE5A, PPARA, PTPN1, SRC, XDH 2.24214
[BP] GO:0046777 protein autophosphorylation AURKB, FLT3, IGF1R, KDR, PIM1, SRC 2.24214
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.24214
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.24214
[BP] GO:0050995 None ADORA1, ADRA2A, HCAR2 2.24214
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, MMP2, PPARA, SLC6A4, SRC, TERT 2.21656
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA2A, ALOX15, CDC25B, ESRRB, FABP3, FABP4, FLT3, HMGCR, IGF1R, KDR, MMP9, PDE5A, PPARA, PTPN1, SRC, XDH 2.21042
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.18858
[BP] GO:0006145 None AOX1, XDH 2.17347
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.17347
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.17347
[BP] GO:0043393 regulation of protein binding AURKB, MET, MMP9, PPARA, SRC, TERT 2.16082
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.15716
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B2 2.15322
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, TERT 2.13843
[BP] GO:0048878 chemical homeostasis ADRA2A, AKR1B1, ALOX12, CA12, CA2, CA7, ESR1, FABP3, FABP4, KCNH2, MET, TRPV1 2.13843
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, KDR, SRC, TRPV1 2.13744
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA2A, ALOX15, CDC25B, FLT3, HMGCR, KDR, MMP9, PDE5A, PTPN1, SRC, XDH 2.13346
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, HMGCR 2.07063
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.06162
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, AXL, CA2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, MAOB, MMP9, PIM1, PPARA, RORC, SRC, TYR 2.05369
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, ADRA2A, CYP19A1, HCAR2, HMGCR, MAOB, MMP12, SLC6A4, SRC 2.03297
[BP] GO:0071495 cellular response to endogenous stimulus ADRA2A, AKR1B1, ESR1, FLT3, IGF1R, MMP2, NR3C1, SLC6A4, SRC, TRPV1 2.02957
[CC] GO:0044432 endoplasmic reticulum part CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, FLT3, HMGCR, HSD11B1, HSD17B2, PTPN1 2.52067
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, AURKB, CA1, CA2, CA4, CA5A, CA5B, CA7, CDC25B, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, ESR1, ESR2, FABP3, FABP4, FLT3, HMGCR, HSD11B1, HSD17B2, KCNH2, KDR, MAOB, MMP2, MMP9, NR3C1, PDE5A, PIM1, PTPN1, SLC6A4, SRC, TERT, TRPV1, TYR, XDH 2.41079
[CC] GO:0097443 sorting endosome KDR, PTPN1 1.8589
[CC] GO:0005789 endoplasmic reticulum membrane CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, HMGCR, HSD11B1, HSD17B2 1.70261
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRA2A, ALOX12, ALOX15, ALOX5, AXL, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, ESR1, FLT3, HCAR2, HMGCR, HSD11B1, HSD17B2, IGF1R, KCNH2, KDR, MAOB, MET, MMP2, PIM1, PTPN1, SLC6A2, SLC6A4, SRC, TERT, TRPV1, TYR 1.59495
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, TYR, XDH 23.0842
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 17.4654
[MF] GO:0043167 ion binding ACHE, ALOX12, ALOX15, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HMGCR, IGF1R, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PDE5A, PIM1, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, SRC, TERT, TRPV1, TYR, XDH 12.4537
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.0089
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NR3C1, PDE5A, PIM1, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, TERT, TRPV1, TYR, XDH 10.8136
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, XDH 10.8136
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, FLT3, HMGCR, HSD11B1, HSD17B2, IGF1R, KCNH2, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, PDE5A, PIM1, PTPN1, SRC, TERT, TYR, XDH 10.8136
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NR3C1, PDE5A, PIM1, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, TERT, TRPV1, TYR, XDH 10.4347
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.90622
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NR3C1, PPARA, PTPN1, RORC 9.66963
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, HMGCR, HSD11B1, HSD17B2, MAOB, TYR, XDH 9.53068
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 8.59536
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, TYR 7.55075
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 7.08225
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, CYP3A4 6.98794
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, SRC 6.54362
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 6.4469
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, SRC 6.27421
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 6.20944
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2C19, CYP3A4 6.10614
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, TYR 5.90608
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, HMGCR, MAOB, SRC, XDH 5.48731
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.251
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.251
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, ESRRA, ESRRB, NR3C1, RORC 5.23695
[MF] GO:0008289 lipid binding ALOX15, AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, NR3C1, PPARA, RORC, TRPV1 3.99448
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HMGCR, HSD11B1, HSD17B2, XDH 3.99448
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA2A, AXL, ESR1, ESR2, ESRRA, ESRRB, FLT3, HCAR2, IGF1R, KCNH2, KDR, MET, NR3C1, PPARA, RORC, TRPV1 3.89983
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, MAOB, XDH 3.44306
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.3753
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ADRA2A, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SRC 3.35141
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA2A, AXL, ESR1, ESR2, ESRRA, ESRRB, FLT3, HCAR2, IGF1R, KCNH2, KDR, MET, NR3C1, PPARA, RORC, TRPV1 3.27116
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, CYP3A4, FLT3, IGF1R, KDR, MET, PIM1, PPARA, SLC6A4, SRC, TRPV1 3.2531
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.2531
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA2A, AXL, ESR1, ESR2, ESRRA, ESRRB, FLT3, HCAR2, IGF1R, KCNH2, KDR, MET, NR3C1, PPARA, RORC, TRPV1 3.10154
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, ADRA2A, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SLC6A4, SRC 3.072
[MF] GO:0042802 identical protein binding ACHE, ADRA2A, AOX1, ESR1, ESR2, FLT3, HMGCR, IGF1R, KCNH2, KDR, MAOB, MET, MMP9, SLC6A4, TERT, TRPV1, TYR, XDH 3.02083
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.92946
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.78037
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 2.78037
[MF] GO:0008389 None CYP2A13, CYP2A6 2.78037
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA2A, AXL, ESR1, ESR2, ESRRA, ESRRB, FLT3, HCAR2, IGF1R, KCNH2, KDR, MET, NR3C1, PPARA, RORC, TRPV1 2.77603
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.67813
[MF] GO:0008392 None CYP2A13, CYP2A6, CYP2C19 2.50463
[MF] GO:0008391 None CYP2A13, CYP2A6, CYP2C19 2.50463
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.41079
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.41079
[MF] GO:0005330 None SLC6A2, SLC6A4 2.41079
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.41079
[MF] GO:0047374 None CES1, CES2 2.41079
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.40372
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.3411
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HMGCR, HSD11B1, HSD17B2 2.24776
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.17347
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.17347
[MF] GO:0032795 None ADORA1, ADRA2A 2.17347
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.17347
[MF] GO:0042803 protein homodimerization activity ACHE, ADRA2A, AOX1, FLT3, HMGCR, KCNH2, MAOB, SLC6A4, TERT, TYR, XDH 2.15506
[MF] GO:0019899 enzyme binding ADRA2A, AURKB, CDC25B, CYP1A1, CYP1A2, CYP2A6, CYP2C19, CYP3A4, ESR1, ESR2, ESRRB, HMGCR, KCNH2, MET, NR3C1, PPARA, PTPN1, SLC6A4, SRC 2.08162
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX12, ALOX15, ALOX5 2.06162
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX12, ALOX15, ALOX5 2.01886


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 18.776
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP2C19 7.8069
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 7.501
Metabolic pathways_Homo sapiens_hsa01100 MAOB, ALOX15, AKR1B1, ALOX12, HMGCR, TYR, CYP3A4, CYP2C19, CYP19A1, HSD11B1, CYP2A6, AKR1B10, ALOX5, HSD17B2, CYP1A2, CYP1A1, AOX1, XDH, CES1 6.6167
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 6.909
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 6.5482
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, MAOB, CYP1A2, AOX1, CYP3A4, CYP2C19 5.7587
Tryptophan metabolism_Homo sapiens_hsa00380 MAOB, CYP1A2, CYP1A1, AOX1, CYP1B1 5.5299
Serotonergic synapse_Homo sapiens_hsa04726 MAOB, ALOX5, ALOX15, ALOX12, CYP2C19, SLC6A4 4.7031
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH, CES2, CES1 5.3147
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 4.4064
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1, CYP3A4 4.6629
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, ESR2 3.8598
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.1083
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, ALOX12, CYP2C19 3.4442
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4, CYP2C19 4.6629
Adherens junction_Homo sapiens_hsa04520 PTPN1, SRC, MET, IGF1R 3.191
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.2863
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, MMP9, MET, IGF1R 2.0009
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, ADORA1, TRPV1, NR3C1, ADRA2A 1.9755
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.0337
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1, PDE5A, ADRA2A 1.9755
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET, CDC25B 1.9048
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR, CYP3A4 2.0337
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.9048
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, ALOX12, TRPV1 1.7734
Tyrosine metabolism_Homo sapiens_hsa00350 MAOB, AOX1, TYR 2.914
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, IGF1R 1.7731
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, IGF1R 1.7335
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.4516
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, ADORA1, PPARA 1.1365
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.011
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.3199
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3172
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.2843
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1 0.9792
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.0336
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.203
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 0.9935
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.2294
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.901
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3004
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.2278
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.9285
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1372
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.901
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.901
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.8959
Hepatitis B_Homo sapiens_hsa05161 SRC, MMP9 0.7862
AMPK signaling pathway_Homo sapiens_hsa04152 HMGCR, IGF1R 0.8788
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.7994
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 KDR, MET, IGF1R 0.7324
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, AOX1 0.756
Purine metabolism_Homo sapiens_hsa00230 PDE5A, XDH 0.6914
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7731
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2395
HTLV-I infection_Homo sapiens_hsa05166 TERT 0.2395
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.2858
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.2951
Alcoholism_Homo sapiens_hsa05034 MAOB 0.3297
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3297
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3197
Platelet activation_Homo sapiens_hsa04611 SRC 0.4126
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.3737
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.4706
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.3625
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4347
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.3977
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.4347
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4126
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.4048
Tight junction_Homo sapiens_hsa04530 SRC 0.3977
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4556
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.4048
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.453
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.4126
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.4173
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4556
Axon guidance_Homo sapiens_hsa04360 MET 0.4085
Dopaminergic synapse_Homo sapiens_hsa04728 MAOB 0.4073
Prostate cancer_Homo sapiens_hsa05215 IGF1R 0.4706
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.465
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4706
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4706
Gap junction_Homo sapiens_hsa04540 SRC 0.4706
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4706
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4706
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.465
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.465
Peroxisome_Homo sapiens_hsa04146 XDH 0.4706
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5085
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.537
Glioma_Homo sapiens_hsa05214 IGF1R 0.537
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6649
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5246
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5396
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5366
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.537
Amphetamine addiction_Homo sapiens_hsa05031 MAOB 0.5361
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.537
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7387
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9326
Shigellosis_Homo sapiens_hsa05131 SRC 0.537
Malaria_Homo sapiens_hsa05144 MET 0.6078
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6078
Cocaine addiction_Homo sapiens_hsa05030 MAOB 0.6078
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOB 0.6059
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6078
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOB 0.6645
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.3525
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.763
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.756
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7854
Histidine metabolism_Homo sapiens_hsa00340 MAOB 0.8128
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOB 0.9017
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.8416
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2407


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)