TCM Prescription: Yi Zhu Tian Wine



Prescription Description
Prescription IDTCMF6348
Pinyin NameYi Zhu Tian Jiu
Chinese Name一柱天酒
English NameYi Zhu Tian Wine
Function Description阳痿, 遗精, 不育, 水肿
IndicationsEdema disorders, Involuntary ejaculation disorder, Impotence disorder, Male Infertility disorder, Infertility, Edema, Sexual dysfunction
Disease ICD-11 Category SB06 [Edema disorders (TM1), 水肿 (TM1) ];
SB09 [Involuntary ejaculation disorder (TM1), 遗精 (TM1) ];
SB0B [Impotence disorder (TM1), 阳痿 (TM1) ];
SB0C [Male Infertility disorder (TM1), 不育 (TM1) ];
GA31 [Female infertility, 女性不孕症 ];
MG29 [Oedema, 水肿 ];
HA0Z [Sexual dysfunctions, unspecified, 性功能障碍，未特指的 ];
Human Tissues Associated with IndicationKidney
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH197 Bombyx mori 蚕蛾 TCMH197 AGIRI001-17
TCMH2507 Epimedium brevicornum 淫羊藿 TCMH2507 AY362429
TCMH31 Morinda officinalis 巴戟天 TCMH31 ITSAJ4459-14
TCMH1966 Rehmannia glutinosa 熟地黄 TCMH1966 ITSAH4578-14
TCMH1845 Dioscorea batatas 山药 TCMH1845
TCMH1862 Cornus officinalis 山茱萸 TCMH1862 ITSAO2979-14
TCMH1186 Lycium chinense 枸杞子 TCMH1186 ITSAO4545-14
TCMH2149 Cuscuta australis 菟丝子 TCMH2149 ITSAP4209-14
TCMH1349 Cervus elaphus 鹿茸 TCMH1349 ABMC060-05
TCMH524 Eucommia ulmoides 杜仲 TCMH524 ITSAM1588-14
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH1742 Cinnamomum cassia 肉桂 TCMH1742 GQ255631
TCMH623 Aconitum carmichaeli 附子 TCMH623 ITSAH2410-14
TCMH2176 Scolopendra subspinipes mutilans 蜈蚣 TCMH2176
TCMH2090 Gastrodia elata 天麻 TCMH2090
TCMH1721 Panax ginseng 人参 TCMH1721 GBVE1679-11
TCMH1332 Penis cervi 鹿鞭 TCMH1332
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT118 MGAM Maltase-glucoamylase Hydrolase O43451
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT18 GAA Lysosomal alpha-glucosidase Hydrolase P10253
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT197 PDE4D Phosphodiesterase 4D Hydrolase Q08499
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT241 CHRNA7 Neuronal acetylcholine receptor protein alpha-7 subunit Ion channel P36544
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT290 CHRM5 Muscarinic acetylcholine receptor M5 GPCR P08912
TCMT291 CHRM3 Muscarinic acetylcholine receptor M3 GPCR P20309
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT552 CHRNA3 Neuronal acetylcholine receptor subunit alpha-3 Ion channel P32297
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT605 EDNRA Endothelin receptor ET-A GPCR P25101
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT698 PDE4B Phosphodiesterase 4B Hydrolase Q07343
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT848 ERN1 Serine/threonine-protein kinase/endoribonuclease IRE1 Kinase O75460
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1172 Staphylococcus aureus subsp. aureus RN4220
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1292 Japanese encephalitis virus
TCMT1294 Human parainfluenza virus 3
TCMT1319 Corynebacterium xerosis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1336 Yellow fever virus
TCMT1337 Dengue virus type 4
TCMT1338 Rift Valley fever virus
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1354 Streptococcus mutans UA159
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CHRM1, CHRM3, CHRNA3, CHRNA7, CYP19A1, CYP1A1, CYP1B1, DRD3, EDNRA, ESR1, F10, FABP3, FABP4, FLT3, GAA, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSD11B1, HSD17B1, HSD17B2, KDR, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SLC1A1, SRC, XDH 11.6335
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, ESR1, FABP3, FABP4, FUT7, HMGCR, HSD11B1, HSD17B1, HSD17B2, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 11.6335
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.0939
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, FUT7, GAA, GLO1, HMGCR, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TYR, XDH 11.0939
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 10.4873
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CA9, CHRNA3, CHRNA7, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, ESR1, FABP3, GRIK5, GRM5, HMGCR, HSD17B2, IGF1R, MMP2, MMP9, PIK3CA, PPARA, PTGS2, RORC, SRC, TYR 10.3575
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 10.3575
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.3531
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 9.39122
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 9.10196
[BP] GO:0007193 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD3, GRM1, GRM3, GRM5, GRM8 9.02654
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CHRNA3, CHRNA7, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD17B2, IGF1R, KDR, MMP2, PIK3CA, PPARA, PTGS2, RORC, SRC, TYR 8.82907
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, GAA, HMGCR, HSD11B1, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 8.76762
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, ESR1, HMGCR, HSD11B1, HSD17B1, HSD17B2 8.66291
[BP] GO:0007215 None APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.97078
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 7.92266
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, CHRNA3, CHRNA7, DRD3, GRIK5, GRM1, GRM3, GRM5, GRM8, PTGS2 7.62892
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, CHRNA3, CHRNA7, DRD3, GRIK5, GRM1, GRM3, GRM5, GRM8, PTGS2 7.62892
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CHRM1, CHRM3, CHRM5, CHRNA3, CHRNA7, CYP19A1, CYP1A2, CYP1B1, DRD3, EDNRA, ESR1, F10, FABP4, GAA, GRM1, GRM5, GRM8, HMGCR, HSD17B2, IGF1R, MET, MGAM, MMP1, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SRC, TYR 7.59156
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 7.44044
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, FABP4, FUT7, HMGCR, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 7.43297
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CHRNA7, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, GRIK5, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, TOP2A, XDH 7.39711
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CHRNA3, CHRNA7, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD17B2, IGF1R, KDR, MMP2, MMP9, PIK3CA, PPARA, PTGS2, RORC, SRC, TYR 7.24156
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, CHRM5, CHRNA3, CHRNA7, DRD3, EDNRA, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 6.89297
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, CHRM5, CHRNA3, CHRNA7, DRD3, EDNRA, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 6.82316
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PPARA, PTGS1, PTGS2 6.77835
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, GRIK5, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TOP2A, XDH 6.75364
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CHRNA7, CSNK2A1, CYP19A1, CYP1B1, DRD3, F10, FLT3, GRM1, HCAR2, HMGCR, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 6.74732
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CBR1, CDC25B, CHRM1, CHRM2, CHRM3, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EDNRA, ESR1, FABP4, FLT3, FUT7, GAA, GLO1, HMGCR, HSD11B1, HSD17B2, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RORC, SRC, TOP2A, TYR 6.72481
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CHRNA7, CSNK2A1, CYP19A1, CYP1B1, DRD3, F10, FLT3, GRM1, HCAR2, HMGCR, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 6.72442
[BP] GO:0095500 None CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7 6.72073
[BP] GO:1903831 None CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7 6.72073
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, PTGS2, SRC 6.45815
[BP] GO:0007188 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD3, GRM1, GRM3, GRM5, GRM8 6.37307
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APEX1, APP, AXL, BCL2, CA12, CA2, CA7, CHRNA7, DRD3, EDNRA, ESR1, FABP3, FABP4, FLT3, GAA, GRIK5, GRM1, GRM5, MET, PIK3CA, PIK3CB, SRC 6.36996
[BP] GO:0007197 None CHRM1, CHRM2, CHRM3, CHRM5 6.29791
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, GRIK5, HCAR2, HMGCR, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TOP2A, XDH 6.26148
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD3, FABP3, PPARA, SLC1A1 6.12759
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CHRNA7, CYP1B1, F10, FLT3, GRM1, HMGCR, KDR, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.99377
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, APP, BCL2, CA2, CA9, CHRNA3, CHRNA7, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, PTGS2, SRC 5.95476
[BP] GO:0007268 None CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 5.95476
[BP] GO:0098916 None CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 5.95476
[BP] GO:0007207 None CHRM1, CHRM2, CHRM3, CHRM5 5.87851
[BP] GO:0099536 None CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 5.86837
[BP] GO:0099537 None CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 5.86837
[BP] GO:0007187 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD3, GRM1, GRM3, GRM5, GRM8 5.82177
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, ESR1, FLT3, PTGS2, RORC, SRC, TYR 5.65017
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.56179
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.56179
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, CHRNA3, CHRNA7, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.50982
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GLO1, PPARA, PTGS1, PTGS2 5.47891
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CHRNA3, CHRNA7, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, PPARA, PTGS2, SRC 5.43728
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CHRNA7, CSNK2A1, CYP1B1, DRD3, ESR1, F10, FLT3, GRM1, HMGCR, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.39965
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA6, CA9, CHRM2, CHRNA3, CHRNA7, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EDNRA, ESR1, F10, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HMGCR, HSD17B2, IGF1R, KDR, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TOP2A, TYR 5.3647
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD3, ESR1, F10, FABP3, FABP4, FLT3, FUT7, GAA, GLO1, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, MET, MGAM, MMP1, MMP2, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TOP2A, TYR, XDH 5.32396
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.26254
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1B1, DRD3, ESR1, F10, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.26254
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, CHRNA3, CHRNA7, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.25987
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, PIK3CA, PTGS2, RORC, SRC 5.25987
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, CHRNA3, CHRNA7, FABP3, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.25987
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, CHRNA3, CHRNA7, FABP3, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.25987
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD3, ESR1, F10, FABP3, FABP4, FLT3, FUT7, GAA, GLO1, HMGCR, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MGAM, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TOP2A, TYR, XDH 5.2495
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, NQO2, PTGS1, RORC 5.20777
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CHRM1, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD3, ESR1, F10, FABP3, FLT3, GRIK5, GRM1, GRM5, HCAR2, HMGCR, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TOP2A, XDH 5.18104
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CHRM1, CHRM3, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD3, ESR1, F10, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HCAR2, HMGCR, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC1A1, SRC, TOP2A, XDH 5.17157
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1B1, DRD3, ESR1, F10, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.16222
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, MMP9, PIK3CA, PTGS2, RORC, SRC 5.15578
[BP] GO:0060078 None ADORA1, CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5, GRM5 5.13234
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.12264
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CHRM5, CYP1A1, DRD3, FABP3, FLT3, HCAR2, HMGCR, PPARA, PTGS2, RORC, SRC 5.08515
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, BCL2, CDC25B, CHRM1, CHRNA7, CSNK2A1, CYP1B1, DRD3, ESR1, FABP3, FLT3, HMGCR, IGF1R, KDR, MMP2, MMP9, PIM1, PTGS1, PTGS2, SRC, XDH 5.07817
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CHRNA7, CSNK2A1, CYP1B1, DRD3, F10, FLT3, GRM1, HMGCR, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.02946
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, ESR1, FABP3, FLT3, HSD17B2, PTGS2, RORC, SRC, TYR 5.00019
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD3, FABP3, PPARA, SLC1A1 4.90347
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, CHRNA7, DRD3, EDNRA, ESR1, FABP3, FABP4, GRIK5, GRM1, GRM5, MET, PIK3CA, PIK3CB 4.88441
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, HMGCR, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SRC 4.84379
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, HMGCR, HSD11B1, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 4.84055
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD17B1, HSD17B2 4.78152
[BP] GO:0007271 None CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3 4.77659
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CHRM1, CHRM3, CHRM5, CYP1A1, EDNRA, ESR1, FLT3, MET, PIK3CB, PIM1, SRC, TYR 4.77177
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, HMGCR, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SRC 4.68545
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CHRNA7, CYP1A1, CYP1B1, DRD3, HMGCR, KDR, SRC 4.65532
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AXL, BCL2, CA2, CA7, CHRM1, CHRNA3, CSNK2A1, CYP19A1, CYP1B1, DRD3, F10, GRIK5, GRM5, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SRC 4.5694
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, GRM1, GRM3, GRM5, GRM8, PTGS2 4.50337
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, CHRNA3, CHRNA7, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 4.47677
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, CHRNA3, CHRNA7, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.45911
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CHRNA3, CYP19A1, CYP1A1, CYP1B1, ESR1, HCAR2, HMGCR, HSD11B1, HSD17B1, HSD17B2 4.44301
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.31419
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.31419
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, CYP2D6, DRD3, ESR1, FABP4, GRM3, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC 4.28123
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CHRM1, CHRM2, CHRM3, CHRNA3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EDNRA, ESR1, FLT3, GAA, HSD11B1, HSD17B2, KDR, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SRC, TYR 4.28011
[BP] GO:0006940 None ADORA1, CHRM1, CHRM2, CHRM3, CHRNA3, PTGS2 4.27869
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM5, CHRNA3, CHRNA7, DRD3, FABP3, GRIA2, GRIA4, GRIK5, PPARA, SLC1A1 4.22437
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.22437
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD3, EDNRA, ESR1, F10, FABP3, FABP4, FLT3, FUT7, GAA, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, MET, MGAM, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SRC, TOP2A, TYR, XDH 4.20704
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, BCL2, CA9, CHRNA3, CHRNA7, CYP1A1, CYP1B1, DRD3, FABP3, HMGCR, KDR, PTGS2, SRC 4.18128
[BP] GO:0060079 None ADORA1, CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5 4.13847
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, HMGCR, IGF1R, KDR, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SRC 4.095
[BP] GO:0007213 None CHRM1, CHRM2, CHRM3, CHRM5 4.09468
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, APP, BCL2, CDC25B, CHRNA3, CHRNA7, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.07867
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GLO1, PIM1, PPARA, PTGS1, PTGS2, TYR 4.07867
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, IGF1R, KDR, MMP2, MMP9, PIK3CA, PTGS2, PTPN1, RORC, SRC, TOP2A 4.07867
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AXL, CYP1B1, ESR1, GRIK5, GRM5, IGF1R, MMP2, MMP9, PIK3CA, PTGS2, RORC, SRC 4.0699
[BP] GO:0007154 None ADORA1, AXL, BCL2, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, PTGS2, SLC1A1 4.01959
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, DRD3, HCAR2, HMGCR, KDR, PIK3CB, PTGS2, SRC 3.9711
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CHRM1, CHRNA7, CSNK2A1, DRD3, ESR1, FLT3, HMGCR, IGF1R, KDR, MMP2, MMP9, PIM1, PTGS2 3.9267
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CHRNA7, CYP1A1, DRD3, EDNRA, GRM1, HMGCR, MMP2, PPARA, PTGS2, SRC, TYR 3.90411
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, APP, BCL2, CHRM1, CYP19A1, CYP1B1, DRD3, F10, IGF1R, KDR, MET, MMP9, PTGS2, SRC 3.8938
[BP] GO:0042391 None ADORA1, APP, BCL2, CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC 3.86239
[BP] GO:0019725 cellular homeostasis APEX1, APP, BCL2, CA2, CA7, CHRNA7, DRD3, EDNRA, ESR1, GAA, GRIK5, GRM1, GRM5, PIK3CA, PIK3CB 3.86239
[BP] GO:0003008 None ADORA1, AKR1B1, APP, BCL2, CHRM1, CHRM3, CHRM5, CHRNA7, CYP1B1, DRD3, EDNRA, GAA, GRM1, GRM5, GRM8, HMGCR, PIK3CA, PTGS2, SRC, TYR 3.85527
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, CHRNA3, CHRNA7, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, PIK3CA, PIK3CB, PTPN1, SRC 3.8473
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, DRD3, HMGCR, TYR 3.73141
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, APP, CA2, CHRM1, CHRM2, CHRM3, CHRM5, DRD3, EDNRA, ESR1, GRM1, GRM3, GRM5, GRM8, HCAR2, PIK3CA, PIK3CB, SRC 3.71197
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CHRNA7, CYP1A1, EDNRA, MMP2, PPARA, PTGS2, SRC 3.69166
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, APP, CHRNA7, FLT3, GRM1, HMGCR, KDR, PIK3CB, PTPN1, SRC, XDH 3.67499
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AURKB, BCL2, CDC25B, CHRNA3, CHRNA7, CSNK2A1, DRD3, EDNRA, ESR1, FABP4, FLT3, GRM1, GRM3, GRM5, HMGCR, IGF1R, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.65466
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, CHRNA3, CHRNA7, DRD3, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, PTGS2, SRC, TYR 3.65466
[BP] GO:0007200 None CHRM1, CHRM2, CHRM3, CHRM5, ESR1, GRM5 3.62056
[BP] GO:0044057 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, CHRNA3, DRD3, GAA, GRM1, HCAR2, PTGS2, SLC1A1 3.62056
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, BCL2, CYP1B1, MMP9, PTGS1, PTGS2, SRC 3.62005
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EDNRA, ESR1, FLT3, HSD11B1, HSD17B2, KDR, PIK3CA, PPARA, SRC, TYR 3.61036
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CHRNA7, CYP1A1, EDNRA, MMP2, PPARA, PTGS2, SRC 3.61036
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GLO1, PIM1, PPARA, PTGS1, PTGS2, TYR 3.5948
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CHRNA7, CSNK2A1, CYP1B1, DRD3, F10, FABP4, FLT3, GRM1, HMGCR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.57426
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, CHRNA7, FABP3, GRM5, IGF1R, PPARA, PTGS2, SRC 3.57046
[BP] GO:0007267 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 3.57001
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, APP, CYP1A1, CYP1B1, ESR1, FLT3, PTGS2, RORC, SRC 3.55754
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, CDC25B, CHRNA3, CHRNA7, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, PIK3CA, PIK3CB, PTPN1, SRC 3.52033
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GLO1, PIM1, PPARA, PTGS1, PTGS2, TYR 3.51698
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, CHRNA3, CHRNA7, CSNK2A1, ESR1, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.48432
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.45612
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD3, F10, MET, PIK3CA, PIK3CB, SRC, XDH 3.43593
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD3, ESR1, PPARA, RORC, SRC, TOP2A 3.42744
[BP] GO:0055082 cellular chemical homeostasis APP, BCL2, CA2, CA7, CHRNA7, DRD3, EDNRA, ESR1, GRIK5, GRM1, GRM5, PIK3CA, PIK3CB 3.39049
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, CHRNA7, DRD3, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, PTGS2, SRC, TYR 3.38938
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CHRNA7, CYP1A1, EDNRA, MMP2, PPARA, PTGS2, SRC 3.34814
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AXL, BCL2, CA1, CA2, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7, CSNK2A1, CYP1B1, DRD3, EDNRA, ESR1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTPN1, RORC, SRC 3.32769
[BP] GO:0035235 None APP, GRIA2, GRIA4, GRIK5 3.32661
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, F10, IGF1R, KDR, MET, MMP9, PTGS2, SRC 3.32128
[BP] GO:0003018 None ADORA1, CHRM1, CHRM3, EDNRA, HMGCR, PTGS2, SRC 3.32128
[BP] GO:0050801 ion homeostasis APP, BCL2, CA12, CA2, CA7, CHRNA7, DRD3, EDNRA, ESR1, FABP3, GRM1, GRM5, PIK3CB 3.29339
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, CHRNA3, CHRNA7, ESR1, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.29339
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, CHRNA3, CHRNA7, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, PIK3CA, PIK3CB, PTPN1, SRC 3.27068
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, FABP3, FABP4, FUT7, GAA, MGAM, MMP1, MMP2, MMP9, PIK3CB, SRC, XDH 3.23254
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD17B1, HSD17B2 3.18802
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC 3.15922
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 3.15922
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, APP, AXL, BCL2, CA2, CA7, CHRM1, CHRNA3, CYP19A1, DRD3, GRIK5, GRM5, HCAR2, HMGCR, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SRC 3.15629
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 3.14833
[BP] GO:0023052 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 3.12109
[BP] GO:1904645 response to amyloid-beta APP, CHRNA7, GRM5, IGF1R 3.10551
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 3.07466
[BP] GO:0010038 response to metal ion ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 3.0709
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 3.05693
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.05693
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, F10, IGF1R, KDR, MET, MMP9, PTGS2, SRC 3.04813
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, MMP9, SRC 3.0354
[BP] GO:0006810 None ACHE, ADORA1, ALOX15, ALOX5, APP, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CHRM3, CHRM5, CHRNA3, CHRNA7, DRD3, EDNRA, F10, FABP3, GAA, GRIA2, GRIA4, GRIK5, MGAM, MMP9, PPARA, SLC1A1, SRC, XDH 3.02393
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, APP, CHRNA7, FLT3, GRM1, HMGCR, IGF1R, KDR, PIK3CB, PTPN1, SRC, XDH 3.00813
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, CHRNA3, CHRNA7, FLT3, GRM1, GRM5, PIK3CA, PIK3CB, PTPN1, SRC 2.97007
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1, HMGCR 2.96233
[BP] GO:0031399 regulation of protein modification process ADORA1, ALOX15, APP, BCL2, CDC25B, CHRNA3, CHRNA7, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.95781
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DRD3, ESR1, HMGCR, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 2.95232
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, APP, AURKB, BCL2, CDC25B, CHRNA3, CHRNA7, CSNK2A1, CYP1B1, CYP2D6, DRD3, EDNRA, ESR1, FABP4, FLT3, GRM1, GRM3, GRM5, HMGCR, IGF1R, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, XDH 2.94703
[BP] GO:0019371 None CBR1, PTGS1, PTGS2 2.94163
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, CHRNA7, PTGS2 2.91543
[BP] GO:1900543 None DRD3, EDNRA, GRM3, GRM8, PPARA 2.91486
[BP] GO:0045980 None DRD3, EDNRA, GRM3, GRM8, PPARA 2.88883
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 2.88883
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, CHRNA7, FLT3, GRM1, HMGCR, IGF1R, PIK3CB, PTPN1, SRC 2.88503
[BP] GO:0097746 None ADORA1, CHRM1, CHRM3, EDNRA, HMGCR, PTGS2 2.86695
[BP] GO:0035296 None ADORA1, CHRM1, CHRM3, EDNRA, HMGCR, PTGS2 2.86695
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HMGCR 2.8498
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, FLT3, HMGCR, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, XDH 2.83824
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HMGCR, HSD11B1, HSD17B1, HSD17B2 2.83376
[BP] GO:0098771 inorganic ion homeostasis APP, BCL2, CA12, CA2, CA7, CHRNA7, DRD3, EDNRA, ESR1, GRM1, GRM5, PIK3CB 2.82432
[BP] GO:0007610 None APP, BCL2, CHRNA3, CHRNA7, DRD3, GAA, GRM1, GRM5, HMGCR, PPARA, PTGS2 2.81019
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, CHRNA3, CHRNA7, CSNK2A1, DRD3, ESR1, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SRC, TOP2A, XDH 2.80674
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, PTGS2 2.80072
[BP] GO:0046456 icosanoid biosynthetic process ALOX15, ALOX5, PTGS1, PTGS2 2.79997
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, CHRNA3, CHRNA7, FLT3, GRM1, GRM5, PIK3CA, PIK3CB, PTPN1, SRC 2.76183
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 2.75833
[BP] GO:0051234 None ACHE, ADORA1, ALOX15, ALOX5, APP, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CHRM3, CHRM5, CHRNA3, CHRNA7, DRD3, EDNRA, F10, FABP3, GAA, GRIA2, GRIA4, GRIK5, MGAM, MMP9, PPARA, SLC1A1, SRC, XDH 2.75799
[BP] GO:0050890 None ADORA1, APP, CHRM1, CHRNA7, DRD3, GRM5, HMGCR, PTGS2 2.75636
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.75271
[BP] GO:0050880 None ADORA1, CHRM1, CHRM3, EDNRA, HMGCR, PTGS2 2.74726
[BP] GO:0035150 None ADORA1, CHRM1, CHRM3, EDNRA, HMGCR, PTGS2 2.7321
[BP] GO:0050877 None ADORA1, APP, CHRM1, CHRM5, CHRNA7, CYP1B1, DRD3, GAA, GRM1, GRM5, GRM8, HMGCR, PTGS2, TYR 2.72647
[BP] GO:0097756 None ADORA1, EDNRA, HMGCR, PTGS2 2.72647
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, F10, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.72373
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.66288
[BP] GO:0003013 None ADORA1, CHRM1, CHRM3, EDNRA, HMGCR, PTGS2, SRC 2.65643
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC 2.65643
[BP] GO:0030003 cellular cation homeostasis APP, BCL2, CA2, CA7, CHRNA7, DRD3, EDNRA, ESR1, GRM1, GRM5, PIK3CB 2.65295
[BP] GO:1903522 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, GAA, PTGS2, SLC1A1 2.63327
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, DRD3, KDR, SRC 2.62098
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, CHRNA3, CHRNA7, FLT3, GRM1, GRM5, PIK3CA, PIK3CB, PTPN1, SRC 2.59748
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, FLT3, HMGCR, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, XDH 2.58509
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AXL, BCL2, CA2, CHRM1, CHRM2, CHRM3, CHRNA3, CHRNA7, CYP1B1, DRD3, ESR1, GAA, GRM1, HCAR2, HMGCR, KDR, MET, MMP9, PIK3CA, PIM1, PTGS2, SLC1A1, SRC, XDH 2.5838
[BP] GO:0006873 cellular ion homeostasis APP, BCL2, CA2, CA7, CHRNA7, DRD3, EDNRA, ESR1, GRM1, GRM5, PIK3CB 2.56918
[BP] GO:0006874 cellular calcium ion homeostasis APP, BCL2, CHRNA7, DRD3, EDNRA, ESR1, GRM1, GRM5, PIK3CB 2.56682
[BP] GO:0030818 None DRD3, EDNRA, GRM3, GRM8 2.5421
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.50822
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.50822
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.50822
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.50822
[BP] GO:0051179 None ACHE, ADORA1, ALOX15, ALOX5, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CHRM3, CHRM5, CHRNA3, CHRNA7, DRD3, EDNRA, ESR1, F10, FABP3, GAA, GRIA2, GRIA4, GRIK5, MGAM, MMP9, PPARA, SLC1A1, SRC, XDH 2.50822
[BP] GO:0008217 None ADORA1, DRD3, EDNRA, PPARA, PTGS1, PTGS2 2.49469
[BP] GO:0030803 None DRD3, EDNRA, GRM3, GRM8 2.47784
[BP] GO:0055074 calcium ion homeostasis APP, BCL2, CHRNA7, DRD3, EDNRA, ESR1, GRM1, GRM5, PIK3CB 2.47784
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, CHRNA3, CHRNA7, DRD3, ESR1, FABP3, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SRC, TOP2A, XDH 2.46452
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, F10, MET, PIK3CA, PIK3CB, SRC 2.45394
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, CHRNA3, CHRNA7, CSNK2A1, DRD3, ESR1, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SRC, TOP2A, XDH 2.44611
[BP] GO:0072503 cellular divalent inorganic cation homeostasis APP, BCL2, CHRNA7, DRD3, EDNRA, ESR1, GRM1, GRM5, PIK3CB 2.44297
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD3, HCAR2, PIK3CB, PTGS2 2.42779
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CYP1B1, GRIK5, HCAR2, HMGCR, MMP9, PIK3CB, PTGS2, SRC, TOP2A, XDH 2.41831
[BP] GO:0030815 None DRD3, EDNRA, GRM3, GRM8 2.41758
[BP] GO:0043269 regulation of ion transport ADORA1, APP, BCL2, CA2, CA7, CHRM1, CHRNA3, DRD3, GRM5, MMP9, PTGS2 2.41488
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MMP9, PTGS2, PTPN1, SRC 2.41131
[BP] GO:0099566 None GRM1, GRM5 2.41131
[BP] GO:0000023 None GAA, MGAM 2.41131
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.41131
[BP] GO:1905144 None CHRNA3, CHRNA7 2.41131
[BP] GO:1900372 None DRD3, EDNRA, GRM3, GRM8 2.39903
[BP] GO:0030809 None DRD3, EDNRA, GRM3, GRM8 2.39903
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CYP1B1, GRIK5, HCAR2, HMGCR, MMP9, PIK3CB, PTGS2, SRC, TOP2A, XDH 2.39903
[BP] GO:0032147 activation of protein kinase activity ADORA1, CHRNA3, CHRNA7, GRM1, PIK3CA, PIK3CB, PTPN1, SRC 2.39539
[BP] GO:0030800 None DRD3, EDNRA, GRM3, GRM8 2.36766
[BP] GO:0042752 None ADORA1, DRD3, PPARA, RORC, TOP2A 2.36275
[BP] GO:0006937 None ADORA1, CHRM1, CHRM2, CHRM3, CHRNA3, PTGS2 2.34562
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CHRNA7, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD3, EDNRA, ESR1, FABP3, FABP4, GLO1, GRM3, GRM8, HMGCR, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TOP2A, XDH 2.33251
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APEX1, APP, AURKB, BCL2, CHRNA7, CSNK2A1, CYP2D6, DRD3, EDNRA, ESR1, FABP4, GRM3, GRM8, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SRC, XDH 2.32795
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.32349
[BP] GO:0055080 cation homeostasis APP, BCL2, CA2, CA7, CHRNA7, DRD3, EDNRA, ESR1, GRM1, GRM5, PIK3CB 2.32058
[BP] GO:0072507 divalent inorganic cation homeostasis APP, BCL2, CHRNA7, DRD3, EDNRA, ESR1, GRM1, GRM5, PIK3CB 2.31913
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CHRNA7, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD3, EDNRA, ESR1, FABP3, FABP4, GLO1, GRM3, GRM8, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TOP2A, XDH 2.28179
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, DRD3 2.27585
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, CHRNA3, CHRNA7, CSNK2A1, DRD3, ESR1, FABP3, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SRC, TOP2A, XDH 2.25291
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, APP, AURKB, BCL2, CDC25B, CHRNA3, CHRNA7, EDNRA, ESR1, FLT3, GRM1, GRM5, PIK3CA, PIK3CB, PTPN1, SRC, XDH 2.2492
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.21432
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6 2.21131
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.21035
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, CYP2D6, MET, MMP9, PPARA, SRC 2.16857
[BP] GO:0044093 positive regulation of molecular function ADORA1, APP, AURKB, BCL2, CDC25B, CHRNA3, CHRNA7, EDNRA, ESR1, FLT3, GRM1, GRM5, MET, MMP9, PIK3CA, PIK3CB, PTPN1, SRC, XDH 2.16857
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CHRNA3, CYP1B1, DRD3, GRIK5, PTGS2, SLC1A1 2.166
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, F10, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.166
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.166
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.166
[BP] GO:0010942 positive regulation of cell death BCL2, CYP1B1, GRIK5, HCAR2, HMGCR, MMP9, PIK3CB, PTGS2, SRC, TOP2A, XDH 2.15932
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, PPARA 2.13988
[BP] GO:0007626 None APP, CHRNA3, DRD3, GAA, GRM1, GRM5 2.13988
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP2D6 2.13683
[BP] GO:0046903 None ALOX5, APP, AXL, CA2, CA9, CHRM1, CHRM3, CHRM5, DRD3, GAA, MGAM, MMP9, SLC1A1, XDH 2.12325
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, GLO1, MMP9, RORC 2.11708
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.11559
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.11559
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, MMP2, MMP9 2.11072
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 2.09885
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, CHRNA7, FLT3, GRM1, PIK3CB, PTPN1, SRC 2.09269
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.09269
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BCL2, CBR1, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, ESR1, F10, FABP3, FABP4, FLT3, FUT7, GAA, GLO1, HMGCR, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MGAM, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TOP2A, TYR, XDH 2.08779
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, F10, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.07401
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.0712
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.07102
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.04447
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.03674
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIM1, SRC 2.03529
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.02542
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, CHRNA7, HMGCR, KDR, PTPN1, SRC 2.01111
[BP] GO:0048754 branching morphogenesis of an epithelial tube BCL2, EDNRA, ESR1, MET, SRC 2.01089
[BP] GO:0022600 None CHRM1, CHRM3, CHRM5, DRD3 2.00447
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CA9, CHRNA7, CYP1A1, CYP1A2, CYP1B1, EDNRA, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, SRC, TOP2A 2.0005
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, MET, MGAM, PTGS2, SLC1A1, SRC 7.3508
[CC] GO:0097060 None CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 6.89444
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALOX15, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7, CSNK2A1, DRD3, EDNRA, ESR1, F10, FLT3, GAA, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, MGAM, MMP2, PIK3CA, PIK3CB, PIM1, PTPN1, SLC1A1, SRC 6.82088
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD3, EDNRA, ESR1, F10, FLT3, FUT7, GAA, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B2, IGF1R, KDR, MET, MGAM, MMP2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SLC1A1, SRC, TYR 6.72073
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALOX15, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD3, EDNRA, ESR1, F10, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B2, IGF1R, KDR, MET, MGAM, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, SLC1A1, SRC, TYR 6.04862
[CC] GO:0044456 None ACHE, ADORA1, APP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SRC 5.88636
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ALOX15, APP, AXL, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7, DRD3, EDNRA, F10, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MGAM, PTGS2, SLC1A1, SRC 5.45877
[CC] GO:0045211 None CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5, GRM3 5.30194
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, AXL, CA4, CHRM1, CHRM2, CHRM3, CHRM5, DRD3, EDNRA, F10, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1 4.65098
[CC] GO:0043005 None ADORA1, APP, CA2, CHRM1, CHRM2, CHRM3, CHRNA3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PTGS2, SRC 3.8227
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, APP, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD3, EDNRA, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1 3.77154
[CC] GO:0014069 None ADORA1, CHRM1, CHRNA3, GRIK5, GRM1, GRM3, GRM5, SRC 3.61036
[CC] GO:0099572 None ADORA1, CHRM1, CHRNA3, GRIK5, GRM1, GRM3, GRM5, SRC 3.61036
[CC] GO:0044432 endoplasmic reticulum part APP, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, F10, FLT3, GRIA2, HMGCR, HSD11B1, HSD17B2, PTGS1, PTGS2, PTPN1 3.17053
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.15935
[CC] GO:0042995 cell projection ADORA1, AKR1B1, APP, CA2, CHRM1, CHRM2, CHRM3, CHRNA3, DRD3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PIK3CA, PTGS2, SRC 2.82432
[CC] GO:0120025 None ADORA1, AKR1B1, APP, CA2, CHRM1, CHRM2, CHRM3, CHRNA3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PIK3CA, PTGS2, SRC 2.6115
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, GRIA2, HMGCR, HSD11B1, HSD17B2, PTGS1, PTGS2 2.60683
[CC] GO:0005783 None ADORA1, APEX1, APP, BCL2, CA4, CYP19A1, CYP2D6, FLT3, GRIK5, HMGCR, KDR, PTGS2, PTPN1, XDH 2.50822
[CC] GO:0098794 None ADORA1, APP, CHRNA7, GRIA2, GRIA4, GRM3 2.45394
[CC] GO:0043235 receptor complex APP, CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5, GRM1, IGF1R 2.32737
[CC] GO:0097458 None ADORA1, APP, CA2, CHRM1, CHRM2, CHRM3, CHRNA3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, PTGS1, PTGS2, SRC 2.31913
[CC] GO:0098793 None ADORA1, APP, CHRM1, CHRM2, CHRM3, GRIK5 2.29005
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, APP, AURKB, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA7, CBR1, CDC25B, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD3, ESR1, F10, FABP3, FABP4, FLT3, FUT7, GAA, GLO1, GRIA2, GRIA4, GRIK5, HMGCR, HSD11B1, HSD17B1, HSD17B2, KDR, MGAM, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TOP2A, TYR, XDH 2.2492
[CC] GO:0098802 None CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5, GRM1 2.19196
[CC] GO:0045202 None ACHE, APP, CHRM1, CHRM2, CHRM3, CHRM5, GRIA2 2.12364
[CC] GO:0044463 None ADORA1, AKR1B1, APP, CA4, CA9, CHRM1, CHRM2, CHRM3, GRIA2, GRIA4, GRIK5, GRM3, PTGS1, SRC 2.08171
[CC] GO:0120038 None ADORA1, AKR1B1, APP, CA4, CA9, CHRM1, CHRM2, CHRM3, GRIA2, GRIA4, GRIK5, GRM3, PTGS1, SRC 2.08171
[CC] GO:0043197 None ADORA1, APP, GRIA2, GRIA4, GRM3 2.0537
[CC] GO:0044309 None ADORA1, APP, GRIA2, GRIA4, GRM3 2.02542
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 16.16
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, ESR1, GLO1, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, PTPN1, RORC, TYR, XDH 13.6998
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, EDNRA, F10, FLT3, FUT7, GAA, GLO1, HMGCR, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MGAM, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TOP2A, TYR, XDH 11.6335
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.4167
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.3444
[MF] GO:0030594 None CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7, DRD3, GRIA2, GRIA4, GRIK5, GRM1, GRM5 10.2845
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HMGCR, HSD11B1, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 9.49312
[MF] GO:0043167 ion binding ACHE, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM3, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD3, ESR1, F10, FABP3, FABP4, FLT3, GLO1, HMGCR, HSD17B1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SRC, TOP2A, TYR, XDH 9.1795
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 7.97078
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.87669
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1 7.83701
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7, DRD3, EDNRA, ESR1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA, RORC 7.54655
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM3, CHRNA3, CHRNA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD3, ESR1, F10, GLO1, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, TOP2A, TYR, XDH 7.39439
[MF] GO:0015464 None CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7 7.29275
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2, SRC 7.03973
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2, SRC 6.77835
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 6.72073
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7, DRD3, EDNRA, ESR1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA, RORC 6.63448
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2, TYR 6.38064
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM1, CHRM2, CHRM3, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, DRD3, FLT3, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, SRC, TOP2A 6.38064
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7, DRD3, EDNRA, ESR1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA, RORC 6.37307
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7, DRD3, EDNRA, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET 6.33603
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7, DRD3, EDNRA, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET 6.33603
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, XDH 6.29791
[MF] GO:0016907 None CHRM1, CHRM2, CHRM3, CHRM5 6.29791
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7, DRD3, EDNRA, ESR1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA, RORC 5.87245
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, GLO1, MMP1, MMP2, MMP9, NQO2, PPARA, PTPN1, RORC 5.74005
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 5.73856
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HMGCR, HSD17B1, NQO2, PTGS1, PTGS2, SRC, XDH 5.44356
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 5.14318
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, ESR1, F10, GLO1, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, TOP2A, TYR, XDH 5.14318
[MF] GO:0042562 hormone binding ACHE, CHRM3, CHRNA3, CHRNA7, HSD17B1, IGF1R, NQO2 4.8632
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HMGCR, HSD11B1, HSD17B1, HSD17B2, XDH 4.69211
[MF] GO:0004629 None ADORA1, CHRM1, CHRM3, CHRM5, EDNRA 4.55894
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2D6 4.29759
[MF] GO:0042166 None ACHE, CHRM3, CHRNA3, CHRNA7 3.99743
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HMGCR, HSD11B1, HSD17B1, HSD17B2 3.97385
[MF] GO:0098960 None CHRNA3, CHRNA7, GRM1, GRM5 3.65209
[MF] GO:0005231 None CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5 3.63011
[MF] GO:0022824 None CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5 3.57046
[MF] GO:0022835 None CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5 3.57046
[MF] GO:0008081 None ADORA1, APEX1, CHRM1, CHRM3, CHRM5, EDNRA 3.53882
[MF] GO:0004435 None CHRM1, CHRM3, CHRM5, EDNRA 3.27068
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.15935
[MF] GO:0043560 insulin receptor substrate binding IGF1R, PIK3CA, PIK3CB 2.94163
[MF] GO:0070405 ammonium ion binding ACHE, CHRM3, CHRNA3, CHRNA7, DRD3 2.86695
[MF] GO:0005230 None CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5 2.82048
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.80072
[MF] GO:0008389 None CYP2A13, CYP2A6 2.80072
[MF] GO:0099528 None CHRM1, CHRM2, CHRM3, CHRM5 2.75833
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.73498
[MF] GO:0042578 None ADORA1, ALPL, APEX1, CDC25B, CHRM1, CHRM3, CHRM5, EDNRA, PTPN1 2.68198
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.41131
[MF] GO:0032450 None GAA, MGAM 2.41131
[MF] GO:0099583 None GRM1, GRM5 2.41131
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.32349
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.32349
[MF] GO:0042165 neurotransmitter binding ACHE, CHRM3, CHRNA3, CHRNA7 2.31704
[MF] GO:0004620 None ADORA1, CHRM1, CHRM3, CHRM5, EDNRA 2.2966
[MF] GO:0004930 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, CHRM5, DRD3, EDNRA, GRM1, GRM3, GRM5, GRM8, HCAR2 2.29322
[MF] GO:0016788 None ACHE, ADORA1, ALPL, APEX1, CA1, CA2, CDC25B, CHRM1, CHRM3, CHRM5, EDNRA, PTPN1 2.27585
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, NQO2, XDH 2.19481
[MF] GO:0008227 None CHRM1, CHRM2, CHRM3, CHRM5 2.18009
[MF] GO:0004971 None GRIA2, GRIA4 2.166
[MF] GO:0004558 None GAA, MGAM 2.166
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.11849
[MF] GO:0042802 identical protein binding ACHE, APP, BCL2, CHRNA7, CSNK2A1, ESR1, FLT3, GRIK5, HMGCR, IGF1R, KDR, MET, MMP9, NQO2, PTGS2, TOP2A, TYR, XDH 2.08331


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 17.6203
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, GRIA2, CHRM3, CHRNA3, CHRM1, CHRNA7, GRIK5, CHRM5, GRM1, GRM3, GRM5, EDNRA, ADORA3, GRM8, ADORA1, DRD3, GRIA4 13.0304
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM3, CHRNA3, CHRM1, PIK3CA, CHRNA7, CHRM5, BCL2, PIK3CB 8.9329
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 8.9329
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP2A6, CYP2A13, CHRNA7, CYP1A2, CYP1A1, CYP1B1, PTGS2 8.7981
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP2D6, CYP1A2, CYP1A1, CYP1B1 7.7729
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, GRIA2, EDNRA, CHRM1, PIK3CA, ADORA1, PIK3CB, PPARA, GRIA4 6.743
Metabolic pathways_Homo sapiens_hsa01100 CBR1, MGAM, GAA, ALOX15, AKR1B1, HMGCR, PTGS2, TYR, CYP19A1, PTGS1, HSD11B1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH 6.4912
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 7.044
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 6.4412
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, IGF1R 5.6889
Pathways in cancer_Homo sapiens_hsa05200 EDNRA, PIK3CA, FLT3, MMP1, MMP2, BCL2, PIK3CB, PTGS2, MMP9, MET, IGF1R 5.1362
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, ADORA1, PIK3CB, PTGS2, PTGS1 5.7849
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, GRM1 5.6767
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM3, GRM5, EDNRA, CHRM1, CHRNA7, CHRM5, GRM1 5.1123
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 4.3037
Serotonergic synapse_Homo sapiens_hsa04726 APP, CYP2D6, ALOX5, ALOX15, PTGS2, PTGS1 4.2563
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, PTGS2, PTGS1 4.2935
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, BCL2, PIK3CB, MET, IGF1R 3.8353
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM3, CHRM1, PIK3CA, SRC, CHRM5, PIK3CB 3.73
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, PIK3CA, GRM8, PIK3CB, GRM1 3.73
MicroRNAs in cancer_Homo sapiens_hsa05206 PIK3CA, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B 3.7235
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 3.9809
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, BCL2, PIM1, PIK3CB 3.4517
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CHRM1, PIK3CA, KDR, BCL2, PIK3CB, MET, IGF1R 3.3485
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, PTGS2, GRM1, GRIA4 3.4517
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, KDR, PIK3CB, MET, IGF1R 2.9731
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, BCL2, ADORA1, PIK3CB 3.141
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.7673
Hepatitis B_Homo sapiens_hsa05161 PIK3CA, SRC, BCL2, PIK3CB, MMP9 2.833
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.3132
Galactose metabolism_Homo sapiens_hsa00052 MGAM, AKR1B10, GAA, AKR1B1 4.2563
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET 3.0668
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB, MET, IGF1R 2.9957
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1 2.9846
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 EDNRA, PIK3CA, ADORA3, ADORA1, PIK3CB 2.6202
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB, IGF1R 2.6902
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.0306
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, BCL2, PIK3CB, PTGS2 2.7357
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 2.8748
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 2.5737
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, BCL2, PIK3CB, IGF1R 2.5119
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.4239
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, PIK3CB, PPARA 2.4295
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.2925
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1 2.3373
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB 2.3373
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.3373
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB, HMGCR, IGF1R 2.2748
Ras signaling pathway_Homo sapiens_hsa04014 PIK3CA, KDR, PIK3CB, MET, IGF1R 2.1742
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB, GRM1, IGF1R 2.1877
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, PIK3CB 1.9901
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2 1.9901
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.8164
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB 1.6796
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PIK3CB 1.8658
Glioma_Homo sapiens_hsa05214 PIK3CA, PIK3CB, IGF1R 2.1742
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.2288
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, PIK3CB 1.7662
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB, IGF1R 2.1742
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, BCL2, PIK3CB 1.5505
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB, IGF1R 1.8041
Colorectal cancer_Homo sapiens_hsa05210 PIK3CA, BCL2, PIK3CB 2.1959
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.398
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, DRD3, GRIA4 1.4778
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB 1.44
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.186
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, GRM1 1.8586
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.4257
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA 1.4588
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 1.8108
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.2577
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2672
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, PIK3CB 1.4289
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2792
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.2886
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 2.1702
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 PIK3CA, PIK3CB, IGF1R 1.4145
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.2886
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.1702
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB, PPARA 1.3697
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PIK3CB 1.3869
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1 2.1742
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3374
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 MGAM, PIK3CA, PIK3CB 2.5127
Lysosome_Homo sapiens_hsa04142 GAA 0.3763
HTLV-I infection_Homo sapiens_hsa05166 PIK3CA, PIK3CB 0.4764
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.3763
Axon guidance_Homo sapiens_hsa04360 MET 0.3711
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP2D6, CYP1A2 2.1222
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3763
Vascular smooth muscle contraction_Homo sapiens_hsa04270 EDNRA 0.379
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, SRC, PIK3CB 1.1001
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, CHRNA7, GRIA4 2.6336
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.8874
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4356
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4362
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.688
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 1.19
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB 0.6962
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4515
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.6336
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8371
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4639
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4651
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4651
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4651
Salivary secretion_Homo sapiens_hsa04970 CHRM3 0.4651
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 0.8548
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.8639
Insulin secretion_Homo sapiens_hsa04911 CHRM3 0.468
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4651
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4651
Peroxisome_Homo sapiens_hsa04146 XDH 0.4737
Complement and coagulation cascades_Homo sapiens_hsa04610 F10 0.4857
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 1.0121
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB 1.0228
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.0816
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB 1.0376
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.5119
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.0228
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.0906
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 1.0415
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 1.0693
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.0531
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5245
Pancreatic secretion_Homo sapiens_hsa04972 CHRM3, CA2 1.065
Taste transduction_Homo sapiens_hsa04742 CHRM3, GRM1 1.154
Shigellosis_Homo sapiens_hsa05131 SRC 0.5493
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.5493
Chronic myeloid leukemia_Homo sapiens_hsa05220 PIK3CA, PIK3CB 1.2427
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.2427
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.2822
Gastric acid secretion_Homo sapiens_hsa04971 CHRM3, CA2 1.236
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.2563
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR 1.2563
Pancreatic cancer_Homo sapiens_hsa05212 PIK3CA, PIK3CB 1.2929
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, GRIA4 1.2853
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.2822
Renin secretion_Homo sapiens_hsa04924 EDNRA, ADORA1 1.3132
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.3606
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB 1.4291
Non-small cell lung cancer_Homo sapiens_hsa05223 PIK3CA, PIK3CB 1.398
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3697
Malaria_Homo sapiens_hsa05144 MET 0.6521
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2, BCL2 1.44
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2 1.4588
Starch and sucrose metabolism_Homo sapiens_hsa00500 MGAM, GAA 1.398
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, PIK3CB 1.4688
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6653
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.493
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PIK3CA, PIK3CB 1.6191
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.7196
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.7698
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8125
Base excision repair_Homo sapiens_hsa03410 APEX1 0.7905
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.821
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6796
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7662
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8639
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8225
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9901
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8554
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.1362
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.9259
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0816


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)