TCM Prescription: Yu Biao Bu Shen Pills



Prescription Description
Prescription IDTCMF6299
Pinyin NameYu Biao Bu Shen Wan
Chinese Name鱼鳔补肾丸
English NameYu Biao Bu Shen Pills
Function Description眩晕, 耳鸣, 阳痿, 早泄, 遗精, 遗精, 不育, 不孕
IndicationsPremature ejaculation disorder, Involuntary ejaculation disorder, Impotence disorder, Male Infertility disorder, Infertility disorder, Tinnitus disorder, Vertigo disorder, Infertility, Tinnitus, Dizziness, Sexual dysfunction, Premature ejaculation
Disease ICD-11 Category SB08 [Premature ejaculation disorder (TM1), 早泄 (TM1) ];
SB09 [Involuntary ejaculation disorder (TM1), 遗精 (TM1) ];
SB0B [Impotence disorder (TM1), 阳痿 (TM1) ];
SB0C [Male Infertility disorder (TM1), 不育 (TM1) ];
SC22 [Infertility disorder (TM1), 不孕 (TM1) ];
SC75 [Tinnitus disorder (TM1), 耳鸣 (TM1) ];
SD22 [Vertigo disorder (TM1), 眩晕 (TM1) ];
GA31 [Female infertility, 女性不孕症 ];
MC41 [Tinnitus, 耳鸣 ];
MB48 [Dizziness and giddiness, 头晕和眩晕 ];
HA0Z [Sexual dysfunctions, unspecified, 性功能障碍，未特指的 ];
HA03.0Z [Male early ejaculation, unspecified, 男性早泄，未特指的 ];
Human Tissues Associated with IndicationBrain, Kidney
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1186 Lycium chinense 枸杞子 TCMH1186 ITSAO4545-14
TCMH1274 Stamen nelumbinis 莲须 TCMH1274
TCMH31 Morinda officinalis 巴戟天 TCMH31 ITSAJ4459-14
TCMH524 Eucommia ulmoides 杜仲 TCMH524 ITSAM1588-14
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH193 Psoralea corylifolia 补骨脂 TCMH193
TCMH623 Aconitum carmichaeli 附子 TCMH623 ITSAH2410-14
TCMH1588 Achyranthes bidentata 牛膝 TCMH1588 ITSAJ4612-14
TCMH2526 NA 鱼鳔胶 TCMH2526
TCMH1740 Cistanche deserticola 肉苁蓉 TCMH1740 ITSAM2511-14
TCMH2149 Cuscuta australis 菟丝子 TCMH2149 ITSAP4209-14
TCMH1742 Cinnamomum cassia 肉桂 TCMH1742 GQ255631
TCMH2507 Epimedium brevicornum 淫羊藿 TCMH2507 AY362429
TCMH1811 Semen astragali complanati 沙苑子 TCMH1811
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT290 CHRM5 Muscarinic acetylcholine receptor M5 GPCR P08912
TCMT291 CHRM3 Muscarinic acetylcholine receptor M3 GPCR P20309
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT619 HSP90AA1 Heat shock protein HSP 90-alpha Unclassified P07900
TCMT624 HSP90AB1 Heat shock protein HSP 90-beta Unclassified P08238
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT67 PPARG Peroxisome proliferator-activated receptor gamma Nuclear receptor P37231
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1208 Escherichia coli K12
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1319 Corynebacterium xerosis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1354 Streptococcus mutans UA159
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.6198
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.7395
[BP] GO:0007193 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD3, GRM1, GRM3, GRM5, GRM8 9.45219
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 9.45219
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AXL, BCL2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, ESR1, FABP3, GRIK5, GRM5, HSD17B2, HSP90AB1, IGF1R, MMP2, MMP9, PPARA, PPARG, RORC, SRC, TYR 8.9316
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CHRM1, CHRM3, CYP19A1, CYP1A1, CYP1B1, DRD3, ESR1, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, KDR, MET, PPARA, PPARG, SLC1A1, SRC, XDH 8.79817
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KDR, MMP2, PPARA, PPARG, RORC, SRC, TYR 8.79817
[BP] GO:0007215 None APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.38312
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PIM1, PPARA, PPARG, TYR, XDH 8.05277
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, FABP3, FABP4, HSD17B1, HSD17B2, MET, PPARA, PPARG 7.9319
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD3, FABP3, PPARA, PPARG, SLC1A1 7.80405
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KDR, MMP2, MMP9, PPARA, PPARG, RORC, SRC, TYR 7.43742
[BP] GO:0007188 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD3, GRM1, GRM3, GRM5, GRM8 6.80726
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, ESR1, FLT3, HSP90AB1, PPARG, RORC, SRC, TYR 6.53722
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD3, FABP3, PPARA, PPARG, SLC1A1 6.41636
[BP] GO:0007197 None CHRM1, CHRM2, CHRM3, CHRM5 6.32187
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.30083
[BP] GO:0007187 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD3, GRM1, GRM3, GRM5, GRM8 6.27824
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, HSD17B1, HSD17B2 6.25225
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.01257
[BP] GO:0007207 None CHRM1, CHRM2, CHRM3, CHRM5 5.94281
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, ESR1, FABP3, FLT3, HSD17B2, PPARG, RORC, SRC, TYR 5.80522
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.8022
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM5, HSP90AB1, IGF1R, KDR, MMP2, MMP9, PPARG, RORC, SRC 5.74585
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM5, HSP90AB1, IGF1R, KDR, MMP2, PPARG, RORC, SRC 5.71539
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, DRD3, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HSP90AA1, HSP90AB1, MET, PPARG, SRC 5.68435
[BP] GO:0007268 None CHRM1, CHRM2, CHRM3, CHRM5, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 5.61494
[BP] GO:0098916 None CHRM1, CHRM2, CHRM3, CHRM5, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 5.61494
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PPARG 5.56216
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, SRC 5.55093
[BP] GO:0099536 None CHRM1, CHRM2, CHRM3, CHRM5, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 5.54154
[BP] GO:0099537 None CHRM1, CHRM2, CHRM3, CHRM5, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 5.54154
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD3, ESR1, ESR2, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HCAR2, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PPARG, PTPN1, RORC, SLC1A1, SRC, XDH 5.535
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, DRD3, GRIK5, GRM1, GRM3, GRM5, GRM8 5.535
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, DRD3, GRIK5, GRM1, GRM3, GRM5, GRM8 5.535
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.46798
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD3, ESR1, ESR2, FABP3, FLT3, GRIK5, GRM1, GRM5, HCAR2, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PPARG, PTPN1, RORC, SRC, XDH 5.42123
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AXL, BCL2, CA1, CA2, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP1B1, DRD3, ESR1, ESR2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP2, MMP9, PIM1, PPARA, PPARG, PTPN1, RORC, SRC 5.25049
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.23284
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD3, ESR1, ESR2, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AB1, IGF1R, KDR, MET, MMP9, PPARG, PTPN1, SRC, XDH 5.22139
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, FLT3, GRIK5, HCAR2, HSP90AB1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PPARG, PTPN1, SRC, XDH 5.15563
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD3, FLT3, GRM1, HCAR2, HSP90AB1, KDR, MET, MMP9, PTPN1, SRC, XDH 5.12866
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD3, ESR1, ESR2, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AB1, IGF1R, KDR, MET, MMP9, PPARG, PTPN1, SRC, XDH 5.11094
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD3, FLT3, GRM1, HCAR2, HSP90AB1, KDR, MET, MMP9, PTPN1, SRC, XDH 5.10802
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, FLT3, GRIK5, HCAR2, HSP90AB1, IGF1R, KDR, MET, MMP9, PIM1, PPARG, PTPN1, SRC, XDH 5.0409
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CHRM1, CHRM3, CHRM5, CYP19A1, CYP1A2, CYP1B1, DRD3, ESR1, FABP4, GRM1, GRM5, GRM8, HSD17B2, IGF1R, MET, MMP1, MMP2, MMP9, PIM1, PPARA, RORC, SRC, TYR 5.02293
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, PPARG, SRC 4.97899
[BP] GO:0007154 None ADORA1, AXL, BCL2, CHRM1, CHRM2, CHRM3, CHRM5, DRD3, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, PPARG, SLC1A1 4.92647
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CHRM5, CYP1A1, DRD3, FABP3, FLT3, HCAR2, PPARA, PPARG, RORC, SRC 4.83625
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 4.78054
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, CHRM5, DRD3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HSP90AB1, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 4.78054
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, HSD17B2, PPARG, TYR, XDH 4.77099
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, CHRM5, DRD3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HSP90AB1, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 4.73289
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 4.73289
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM5, DRD3, FABP3, GRIA2, GRIA4, GRIK5, PPARA, PPARG, SLC1A1 4.73202
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, HSP90AB1, IGF1R, KDR, MMP2, MMP9, PPARG, PTPN1, RORC, SRC 4.64385
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.58964
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, BCL2, CDC25B, CHRM1, CSNK2A1, CYP1B1, DRD3, ESR1, FABP3, FLT3, IGF1R, KDR, MMP2, MMP9, PIM1, PPARG, SRC, XDH 4.58358
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD3, ESR1, ESR2, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP1, MMP2, PIM1, PPARA, PPARG, PTPN1, RORC, SRC, TYR, XDH 4.53316
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, FLT3, GRIK5, HCAR2, HSP90AB1, IGF1R, KDR, MMP9, PIM1, PPARG, PTPN1, SRC, XDH 4.48467
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.48467
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 4.44973
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.40912
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, MET, PPARA, PPARG 4.39591
[BP] GO:0007267 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD3, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 4.26953
[BP] GO:0007213 None CHRM1, CHRM2, CHRM3, CHRM5 4.25952
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.21772
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, DRD3, GRM1, HSP90AA1, HSP90AB1, MMP2, PPARA, PPARG, SRC, TYR 4.1906
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD3, ESR1, ESR2, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PPARG, PTPN1, RORC, SRC, TYR, XDH 4.18738
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA2, CA6, CA9, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KDR, MMP2, MMP9, PPARA, PPARG, PTPN1, RORC, SRC, TYR 4.12372
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX15, APP, AXL, BCL2, CA2, CA7, CHRM1, CSNK2A1, CYP19A1, CYP1B1, DRD3, GRIK5, GRM5, HCAR2, HSP90AB1, IGF1R, KDR, MET, MMP9, PPARA, PPARG, PTPN1, SRC 4.10283
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, HSD17B2, HSP90AB1, KDR, MMP9, PIM1, PPARA, PPARG, RORC, SRC, TYR 4.09581
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CHRM1, CHRM3, CHRM5, CYP1A1, ESR1, FLT3, MET, PIM1, SRC, TYR 4.09581
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, CYP1A1, CYP1B1, ESR1, FLT3, HSP90AB1, PPARG, RORC, SRC 4.09581
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, DRD3, ESR1, FABP4, GRM3, IGF1R, MET, MMP9, PIM1, PPARA, PPARG, PTPN1, SRC 4.07706
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, PPARA, PPARG, SRC 4.07227
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, FLT3, HSD17B2, HSP90AB1, KDR, PPARA, PPARG, SRC, TYR 3.98947
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, HSP90AB1, MET, MMP9, PPARA, SRC 3.94361
[BP] GO:0007200 None CHRM1, CHRM2, CHRM3, CHRM5, ESR1, GRM5 3.94081
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD3, ESR1, PPARA, PPARG, RORC, SRC 3.91917
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CBR1, CDC25B, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, HSD17B2, HSP90AB1, KDR, MET, MMP2, MMP9, PIM1, PPARA, PPARG, RORC, SRC, TYR 3.9071
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD3, ESR1, ESR2, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PPARG, PTPN1, RORC, SLC1A1, SRC, TYR, XDH 3.88806
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, DRD3, ESR1, FABP3, FABP4, GRIK5, GRM1, GRM5, MET, PPARG 3.86275
[BP] GO:0051972 regulation of telomerase activity AURKB, HSP90AA1, HSP90AB1, PPARG, SRC 3.86275
[BP] GO:0023052 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD3, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 3.85009
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PPARG 3.84509
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HSP90AB1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC 3.83347
[BP] GO:0095500 None CHRM1, CHRM2, CHRM3, CHRM5 3.70318
[BP] GO:1903831 None CHRM1, CHRM2, CHRM3, CHRM5 3.70318
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, DRD3, HSP90AA1, KDR, SRC 3.6517
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.63546
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.63546
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.63546
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HSP90AB1, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC 3.58236
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, APP, CA2, CHRM1, CHRM2, CHRM3, CHRM5, DRD3, ESR1, GRM1, GRM3, GRM5, GRM8, HCAR2, PPARG, SRC 3.58146
[BP] GO:0006810 None ACHE, ADORA1, ALOX15, ALOX5, APP, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CHRM3, CHRM5, DRD3, FABP3, GRIA2, GRIA4, GRIK5, HSP90AA1, HSP90AB1, MMP9, PPARA, PPARG, SLC1A1, SRC, XDH 3.56885
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, DRD3, TYR 3.56246
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AXL, CYP1B1, ESR1, GRIK5, GRM5, IGF1R, MMP2, MMP9, PPARG, RORC, SRC 3.52615
[BP] GO:0035235 None APP, GRIA2, GRIA4, GRIK5 3.51753
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, GRM1, GRM3, GRM5, GRM8 3.51681
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, DRD3, FABP3, FLT3, GRM5, HSP90AB1, IGF1R, MMP2, PPARA, PPARG, SRC, TYR 3.49403
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, BCL2, CHRM1, CYP19A1, CYP1B1, DRD3, IGF1R, KDR, MET, MMP9, PPARG, SRC 3.48295
[BP] GO:0007271 None CHRM1, CHRM2, CHRM3, CHRM5 3.46407
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, PIM1, PPARA, PPARG, RORC, SRC 3.40711
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD3, ESR1, FLT3, GRM1, IGF1R, KDR, MET, MMP9, PTPN1, SRC, XDH 3.40711
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, HSP90AB1, RORC 3.36565
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, HSP90AB1, MET, MMP9, PPARA, PPARG, SRC 3.35548
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, DRD3, FLT3, GRM1, HSP90AB1, KDR, MET, MMP9, PTPN1, SRC, XDH 3.32903
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, APP, AXL, BCL2, CA2, CA7, CHRM1, CYP19A1, DRD3, GRIK5, GRM5, HCAR2, HSP90AB1, MMP9, PPARA, PPARG, PTPN1, SRC 3.29085
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, HSP90AA1, IGF1R, KDR, MET, SRC 3.26151
[BP] GO:0051234 None ACHE, ADORA1, ALOX15, ALOX5, APP, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CHRM3, CHRM5, DRD3, FABP3, GRIA2, GRIA4, GRIK5, HSP90AA1, HSP90AB1, MMP9, PPARA, PPARG, SLC1A1, SRC, XDH 3.25174
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, FLT3, GRM1, GRM5, HSP90AB1, KDR, MMP9, PTPN1, SRC, XDH 3.22398
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, HSP90AA1, IGF1R, KDR, MET, SRC 3.2237
[BP] GO:0048608 reproductive structure development AXL, BCL2, CYP19A1, ESR1, HSD17B2, HSP90AB1, PPARG, SRC 3.20718
[BP] GO:0051179 None ACHE, ADORA1, ALOX15, ALOX5, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CHRM3, CHRM5, DRD3, ESR1, FABP3, GRIA2, GRIA4, GRIK5, HSP90AA1, HSP90AB1, MMP9, PPARA, PPARG, SLC1A1, SRC, XDH 3.19541
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 3.19541
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.19541
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, DRD3, FABP3, FLT3, GRM5, HSP90AB1, IGF1R, MMP2, PPARA, PPARG, SRC, TYR 3.19443
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, FABP3, FLT3, GRM1, GRM5, HSP90AB1, KDR, MMP9, PTPN1, SRC, XDH 3.17097
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, FABP3, FLT3, GRM1, GRM5, HSP90AB1, KDR, MMP9, PTPN1, SRC, XDH 3.17097
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.14047
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CYP1B1, FLT3, GRM1, KDR, MET, PTPN1, SRC, XDH 3.102
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, PPARA, PPARG, RORC, SRC 3.10141
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD3, ESR1, FABP4, FLT3, GRM1, GRM3, GRM5, HSP90AA1, HSP90AB1, IGF1R, MMP9, PPARG, PTPN1, SRC, XDH 3.05465
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, FLT3, GRM1, GRM5, HSP90AB1, KDR, MMP9, PTPN1, SRC, XDH 3.04387
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5 3.03874
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HSP90AB1, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC 3.0342
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PIM1, PPARA, PPARG, TYR 3.01485
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, DRD3, KDR, SRC 3.00079
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CA9, CYP1A1, CYP1B1, DRD3, FABP3, HSP90AB1, KDR, PPARG, SRC 2.98197
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, HSP90AA1, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.97097
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, FABP4, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, IGF1R, PPARG, PTPN1, SRC 2.94199
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD3, ESR1, ESR2, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP9, PPARA, PPARG, PTPN1, RORC, SRC, XDH 2.92309
[BP] GO:0042391 None ADORA1, APP, BCL2, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC 2.91519
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HCAR2, HSD17B1, HSD17B2 2.90974
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, DRD3, FABP4, FLT3, GRM1, HSP90AA1, HSP90AB1, KDR, MET, MMP2, MMP9, PTPN1, SRC, XDH 2.90644
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CHRM1, CSNK2A1, DRD3, ESR1, FLT3, IGF1R, KDR, MMP2, MMP9, PIM1 2.90644
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.88846
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, FABP4, FLT3, GRM1, GRM5, HSP90AB1, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 2.8403
[BP] GO:0046903 None ALOX5, APP, AXL, CA2, CA9, CHRM1, CHRM3, CHRM5, DRD3, HSP90AA1, HSP90AB1, MMP9, SLC1A1, XDH 2.83118
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DRD3, ESR1, ESR2, FABP4, FLT3, GRM1, GRM3, GRM5, HSP90AA1, HSP90AB1, IGF1R, MET, MMP9, PIM1, PPARA, PPARG, PTPN1, SRC, XDH 2.82531
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PPARG, SRC 2.80469
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.80006
[BP] GO:0010038 response to metal ion ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, FABP4, MMP9 2.77188
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, FABP4, FLT3, GRM1, GRM5, HSP90AB1, IGF1R, KDR, MMP9, PTPN1, SRC, XDH 2.71165
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, FLT3, HSP90AA1, IGF1R, KDR, MET, PIM1, SRC 2.66809
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.62364
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PIM1, PPARA, PPARG, TYR 2.61436
[BP] GO:0044093 positive regulation of molecular function ADORA1, APP, AURKB, BCL2, CDC25B, ESR1, ESR2, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, MET, MMP9, PPARG, PTPN1, SRC, XDH 2.60754
[BP] GO:0042752 None ADORA1, DRD3, PPARA, PPARG, RORC 2.59424
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, PPARA, PPARG, RORC, SRC 2.55993
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PPARG, SRC 2.55558
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, APP, AXL, BCL2, CA2, CHRM1, CYP19A1, DRD3, HCAR2, HSP90AB1, PPARG, SRC 2.55558
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PIM1, PPARA, PPARG, TYR 2.54823
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD3, ESR1, ESR2, FABP3, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP9, PPARA, PPARG, PTPN1, RORC, SRC, XDH 2.54498
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, DRD3, ESR1, ESR2, FABP3, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP9, PPARA, PPARG, PTPN1, RORC, SRC, XDH 2.54214
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD3, ESR1, ESR2, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP9, PPARA, PPARG, PTPN1, RORC, SRC, XDH 2.52323
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, GRM5, IGF1R, PPARA, PPARG, SRC 2.52323
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD3, GRIK5, HSP90AA1, HSP90AB1, SLC1A1 2.50731
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC 2.47775
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, CSNK2A1, ESR1, FLT3, GRM1, GRM5, HSP90AB1, KDR, MMP9, PPARG, PTPN1, SRC, XDH 2.47571
[BP] GO:2000278 regulation of DNA biosynthetic process AURKB, HSP90AA1, HSP90AB1, PPARG, SRC 2.47571
[BP] GO:0099566 None GRM1, GRM5 2.45897
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.45897
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.43831
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.4378
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.4378
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, PPARA 2.4355
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, DRD3, HCAR2, KDR, SRC 2.41715
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, ESR1, HSD17B2, HSP90AB1, PPARG, SRC 2.38805
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.3837
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, HSP90AA1, MMP1, MMP2, MMP9, SRC, XDH 2.37793
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AURKB, AXL, BCL2, DRD3, ESR1, IGF1R, KDR, MET, MMP1, MMP9, PPARG, SRC 2.35661
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, MMP2, MMP9 2.34346
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PPARG, SRC 2.26936
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, ESR1, HSD17B2, HSP90AB1, MMP2, MMP9, PPARG, SRC 2.26936
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.26936
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.26051
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, ESR1, FLT3, GRM1, GRM5, HSP90AB1, KDR, MMP9, PPARG, PTPN1, SRC, XDH 2.25009
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, APP, BCL2, CDC25B, FLT3, GRM1, GRM5, HSP90AB1, KDR, MMP9, PTPN1, SRC, XDH 2.22833
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.22014
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, MMP2, PPARA, PPARG, SRC 2.21545
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, APP, FLT3, GRM1, KDR, PTPN1, SRC, XDH 2.21545
[BP] GO:1905323 None HSP90AA1, HSP90AB1 2.21545
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.21545
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PPARG, SRC 2.21545
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, HSP90AA1, HSP90AB1, SRC 2.19884
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DRD3, ESR1, IGF1R, MET, MMP9, PTPN1, SRC, XDH 2.18329
[BP] GO:0035902 response to immobilization stress CYP1A1, CYP1A2, PPARG 2.18329
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.18329
[BP] GO:0022600 None CHRM1, CHRM3, CHRM5, DRD3 2.18224
[BP] GO:0006940 None ADORA1, CHRM1, CHRM2, CHRM3 2.18224
[BP] GO:0044057 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, DRD3, GRM1, HCAR2, SLC1A1 2.17793
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AXL, BCL2, CA2, CHRM1, CHRM2, CHRM3, CYP1B1, DRD3, ESR1, GRM1, HCAR2, HSP90AB1, KDR, MET, MMP9, PIM1, PPARG, SLC1A1, SRC, XDH 2.13978
[BP] GO:1901653 cellular response to peptide AKR1B1, APP, GRM5, IGF1R, PPARG, SRC 2.13745
[BP] GO:0015908 None DRD3, FABP3, PPARA, PPARG 2.13745
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, FABP4, FLT3, GRM1, GRM5, HSP90AB1, IGF1R, PTPN1, SRC 2.13608
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, DRD3 2.13064
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5 2.09502
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, APP, AURKB, BCL2, CDC25B, ESR1, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, PPARG, PTPN1, SRC, XDH 2.09086
[BP] GO:0031399 regulation of protein modification process ADORA1, ALOX15, APP, BCL2, CDC25B, FABP4, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, IGF1R, KDR, MMP9, PTPN1, SRC, XDH 2.08973
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, FLT3, HSP90AA1, IGF1R, KDR, MET, PIM1, PTPN1, SRC, XDH 2.06822
[BP] GO:0050801 ion homeostasis APP, BCL2, CA12, CA2, CA7, DRD3, ESR1, FABP3, GRM1, GRM5 2.06356
[BP] GO:1900543 None DRD3, GRM3, GRM8, PPARA 2.05662
[BP] GO:1904646 cellular response to amyloid-beta APP, GRM5, IGF1R 2.05662
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APP, AURKB, BCL2, CSNK2A1, DRD3, ESR1, ESR2, FABP4, GRM3, GRM8, HCAR2, HSP90AB1, IGF1R, KDR, MET, MMP9, PPARA, PPARG, PTPN1, RORC, SRC, XDH 2.05548
[BP] GO:0031099 regeneration AXL, BCL2, CSNK2A1, FLT3, PPARG 2.05059
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, HSP90AA1, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.05059
[BP] GO:1903725 regulation of phospholipid metabolic process CHRM5, FABP3, FLT3, SRC 2.05059
[BP] GO:0045980 None DRD3, GRM3, GRM8, PPARA 2.05059
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, HSP90AA1, KDR, SRC 2.05059
[BP] GO:0030100 regulation of endocytosis ALOX15, APP, AXL, PPARG, PTPN1, SRC 2.05059
[BP] GO:0046541 None CHRM1, CHRM3 2.05059
[BP] GO:0032800 receptor biosynthetic process ACHE, PPARG 2.05059
[BP] GO:0010891 None PPARA, PPARG 2.05059
[BP] GO:0046320 None FABP3, PPARA, PPARG 2.02787
[BP] GO:0061097 None ADORA1, APP, GRM5, PTPN1 2.00978
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, PTPN1, SRC 2.00862
[BP] GO:0001101 response to acid chemical AKR1B1, FABP3, HSD17B2, KDR, MMP2, PPARG, SRC 2.00862
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, MET, SLC1A1, SRC 7.08594
[CC] GO:0097060 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 5.66633
[CC] GO:0044456 None ACHE, ADORA1, APP, CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SRC 5.28589
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALOX15, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, DRD3, ESR1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AA1, IGF1R, KDR, MET, MMP2, PIM1, PTPN1, SLC1A1, SRC 5.27831
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ALOX15, APP, AXL, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, DRD3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, SLC1A1, SRC 5.07911
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, AXL, CA4, CHRM1, CHRM2, CHRM3, CHRM5, DRD3, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1 4.64385
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, APP, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD3, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1 4.26953
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALOX15, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD3, ESR1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, PTPN1, SLC1A1, SRC, TYR 4.00243
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD3, ESR1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP2, PIM1, PTPN1, SLC1A1, SRC, TYR 3.94081
[CC] GO:0045211 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM3 3.87096
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.42372
[CC] GO:0044463 None ADORA1, AKR1B1, APP, CA4, CA9, CHRM1, CHRM2, CHRM3, GRIA2, GRIA4, GRIK5, GRM3, HSP90AA1, HSP90AB1, SRC 3.35354
[CC] GO:0120038 None ADORA1, AKR1B1, APP, CA4, CA9, CHRM1, CHRM2, CHRM3, GRIA2, GRIA4, GRIK5, GRM3, HSP90AA1, HSP90AB1, SRC 3.35354
[CC] GO:0043005 None ADORA1, APP, CA2, CHRM1, CHRM2, CHRM3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SRC 3.32903
[CC] GO:0014069 None ADORA1, CHRM1, GRIK5, GRM1, GRM3, GRM5, SRC 3.11904
[CC] GO:0099572 None ADORA1, CHRM1, GRIK5, GRM1, GRM3, GRM5, SRC 3.11904
[CC] GO:0098793 None ADORA1, APP, CHRM1, CHRM2, CHRM3, GRIK5 2.57258
[CC] GO:0045202 None ACHE, APP, CHRM1, CHRM2, CHRM3, CHRM5, GRIA2 2.46334
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, CHRM3, HSP90AB1 2.35661
[CC] GO:0043197 None ADORA1, APP, GRIA2, GRIA4, GRM3 2.27373
[CC] GO:0044309 None ADORA1, APP, GRIA2, GRIA4, GRM3 2.25009
[CC] GO:0042995 cell projection ADORA1, AKR1B1, APP, CA2, CHRM1, CHRM2, CHRM3, DRD3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SRC 2.19545
[CC] GO:0043235 receptor complex APP, GRIA2, GRIA4, GRIK5, GRM1, HSP90AB1, IGF1R 2.00862
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 17.0253
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, MMP1, MMP2, MMP9, PIM1, PPARA, PPARG, PTPN1, RORC, TYR, XDH 15.4481
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.7395
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.45219
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD3, ESR1, ESR2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA, PPARG, RORC 8.38312
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.19578
[MF] GO:0030594 None CHRM1, CHRM2, CHRM3, CHRM5, DRD3, GRIA2, GRIA4, GRIK5, GRM1, GRM5 8.16098
[MF] GO:0043167 ion binding ACHE, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD3, ESR1, ESR2, FABP3, FABP4, FLT3, HSD17B1, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PPARG, PTPN1, RORC, SLC1A1, SRC, TYR, XDH 7.75492
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD3, ESR1, ESR2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA, PPARG, RORC 7.45125
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD3, ESR1, ESR2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA, PPARG, RORC 7.19657
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, MMP1, MMP2, MMP9, PPARA, PPARG, PTPN1, RORC 6.66162
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD3, ESR1, ESR2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA, PPARG, RORC 6.65497
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.57378
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FLT3, HSD17B1, HSD17B2, HSP90AA1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PTPN1, SRC, TYR, XDH 6.53722
[MF] GO:0016907 None CHRM1, CHRM2, CHRM3, CHRM5 6.32187
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 6.26776
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARG 6.25225
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARG 6.25225
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD3, ESR1, ESR2, MMP1, MMP2, MMP9, PIM1, PPARA, PPARG, PTPN1, RORC, SLC1A1, TYR, XDH 5.68435
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, XDH 5.66633
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, DRD3, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, PIM1, PPARA, PPARG, SRC 5.42123
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 5.28088
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, HSD17B2, TYR, XDH 5.07911
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 4.92296
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, MMP1, MMP2, MMP9, PIM1, PPARA, PPARG, PTPN1, RORC, SLC1A1, TYR, XDH 4.26953
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC 4.15256
[MF] GO:0015464 None CHRM1, CHRM2, CHRM3, CHRM5 4.07837
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 4.00243
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC 3.97886
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, PPARA, PPARG, RORC 3.86275
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, PPARA, PPARG, RORC 3.86275
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 3.69903
[MF] GO:0030235 nitric-oxide synthase regulator activity ESR1, HSP90AA1, HSP90AB1 3.63546
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, PPARA, PPARG, RORC 3.51681
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.42372
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, HSP90AA1, IGF1R, KDR, MET, SRC 3.32903
[MF] GO:0004629 None ADORA1, CHRM1, CHRM3, CHRM5 3.30805
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6 3.12084
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2, XDH 3.00321
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.99583
[MF] GO:0004930 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, CHRM5, DRD3, GRM1, GRM3, GRM5, GRM8, HCAR2, PPARG 2.96444
[MF] GO:0099528 None CHRM1, CHRM2, CHRM3, CHRM5 2.96201
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.87194
[MF] GO:0008389 None CYP2A13, CYP2A6 2.87194
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, MMP9, PIM1, PPARA, PTPN1, SRC 2.46448
[MF] GO:0042802 identical protein binding ACHE, APP, BCL2, CSNK2A1, ESR1, ESR2, FLT3, GRIK5, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP9, PPARG, TYR, XDH 2.45911
[MF] GO:0099583 None GRM1, GRM5 2.45897
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.43831
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.43831
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, SRC, XDH 2.36826
[MF] GO:0008227 None CHRM1, CHRM2, CHRM3, CHRM5 2.36094
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2 2.2633
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.21545
[MF] GO:0004971 None GRIA2, GRIA4 2.21545
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, HSP90AA1, IGF1R, KDR, MET, PIM1, SRC 2.13745
[MF] GO:0032403 protein complex binding ACHE, ADORA1, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC 2.11979
[MF] GO:0005504 None FABP3, FABP4, PPARG 2.05662
[MF] GO:0004435 None CHRM1, CHRM3, CHRM5 2.05662
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.05059
[MF] GO:0008289 lipid binding ALOX15, AXL, ESR1, ESR2, FABP3, FABP4, HSD17B1, PPARA, PPARG, RORC 2.05059


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 18.5653
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, GRIA2, CHRM3, CHRM1, GRIK5, CHRM5, GRM1, GRM3, GRM5, ADORA3, GRM8, ADORA1, DRD3, GRIA4 10.5229
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.8055
Estrogen signaling pathway_Homo sapiens_hsa04915 HSP90AA1, HSP90AB1, SRC, MMP2, MMP9, ESR1, GRM1, ESR2 7.2677
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 6.8748
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.0005
Pathways in cancer_Homo sapiens_hsa05200 HSP90AA1, HSP90AB1, FLT3, MMP1, MMP2, BCL2, PPARG, MMP9, MET, IGF1R 4.9136
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 5.4609
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM3, CHRM1, CHRM5, BCL2 4.5772
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 5.2414
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, GRIA2, CHRM1, ADORA1, PPARA, GRIA4 4.2856
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 4.277
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, HSP90AA1, HSP90AB1, CHRM1, KDR, BCL2, MET, IGF1R 3.7902
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.2856
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARG, PPARA 4.3693
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM3, GRM5, CHRM1, CHRM5, GRM1 3.5879
Metabolic pathways_Homo sapiens_hsa01100 CBR1, ALOX15, AKR1B1, TYR, CYP19A1, CYP2A6, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH 3.3613
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.0129
Prostate cancer_Homo sapiens_hsa05215 HSP90AA1, HSP90AB1, BCL2, IGF1R 2.7807
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 HSP90AA1, HSP90AB1, CDC25B, IGF1R 2.6621
MicroRNAs in cancer_Homo sapiens_hsa05206 BCL2, PIM1, CYP1B1, MMP9, MET, CDC25B 2.5458
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, GRM1, GRIA4 2.6499
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, PPARG, MMP9, MET, IGF1R 2.656
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, IGF1R 2.4811
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM3, CHRM1, SRC, CHRM5 2.3845
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, GRM8, GRM1 2.1962
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.6621
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.2581
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.1008
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15 2.232
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1 1.7462
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 2.1962
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1 2.1962
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, IGF1R 1.6994
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, GRM1 1.8784
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, ALOX15 1.66
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.4636
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.5931
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, DRD3, GRIA4 1.5272
Hepatitis B_Homo sapiens_hsa05161 SRC, BCL2, MMP9 1.4283
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSP90AA1, HSP90AB1, BCL2 1.3095
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.0848
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.0951
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.9634
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.3771
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PPARG, IGF1R 1.0848
Taste transduction_Homo sapiens_hsa04742 CHRM3, GRM1 1.1613
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 1.0848
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, GRIA4 1.2841
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 1.004
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.3375
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3771
Gastric acid secretion_Homo sapiens_hsa04971 CHRM3, CA2 1.2327
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 1.0419
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.2841
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.259
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.0848
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.9634
FoxO signaling pathway_Homo sapiens_hsa04068 GRM1, IGF1R 0.8867
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1 0.786
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9634
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 0.9634
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.6417
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8592
AMPK signaling pathway_Homo sapiens_hsa04152 PPARG, IGF1R 0.934
Huntington's disease_Homo sapiens_hsa05016 GRM5, PPARG 0.6635
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.7508
Pancreatic secretion_Homo sapiens_hsa04972 CHRM3, CA2 1.0848
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2043
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.7153
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.2795
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2346
Antigen processing and presentation_Homo sapiens_hsa04612 HSP90AA1, HSP90AB1 1.2077
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3568
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2 1.275
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.2941
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 HSP90AA1, HSP90AB1 1.3771
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3193
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3318
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3191
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.3434
Apoptosis_Homo sapiens_hsa04210 BCL2 0.3858
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2, BCL2 1.4349
Measles_Homo sapiens_hsa05162 CSNK2A1 0.3868
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.3752
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.3858
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.3718
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.3601
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2 1.4592
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 IGF1R 0.3858
Platelet activation_Homo sapiens_hsa04611 SRC 0.4047
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3858
Osteoclast differentiation_Homo sapiens_hsa04380 PPARG 0.3909
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.3909
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.4053
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4047
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.4047
Axon guidance_Homo sapiens_hsa04360 MET 0.3999
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4325
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4597
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4597
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.4831
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.4632
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4707
Insulin secretion_Homo sapiens_hsa04911 CHRM3 0.4831
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4831
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4831
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4828
Small cell lung cancer_Homo sapiens_hsa05222 BCL2 0.4831
Salivary secretion_Homo sapiens_hsa04970 CHRM3 0.4831
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4831
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4831
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.4932
Peroxisome_Homo sapiens_hsa04146 XDH 0.4831
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4831
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.5911
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5328
Bile secretion_Homo sapiens_hsa04976 CA2 0.5318
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5528
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.76
Glioma_Homo sapiens_hsa05214 IGF1R 0.5528
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5513
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5528
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.5528
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.5528
Shigellosis_Homo sapiens_hsa05131 SRC 0.5528
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.777
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7277
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.66
Malaria_Homo sapiens_hsa05144 MET 0.6368
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.644
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9519
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.2414
Thyroid cancer_Homo sapiens_hsa05216 PPARG 0.8055
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.7486
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7967
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.83
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0493


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)