TCM Prescription: Xin Qin Infusion



Prescription Description
Prescription IDTCMF6052
Pinyin NameXin Qin Chong Ji
Chinese Name辛芩冲剂
English NameXin Qin Infusion
Function Description鼻鼽, 鼻窒
IndicationsAllergic rhinitis disorder, Allergic rhinitis
Disease ICD-11 Category SC90 [Allergic rhinitis disorder (TM1), 鼻鼽 (TM1) ];
CA08.0 [Allergic rhinitis, 变应性鼻炎 ];
Human Tissues Associated with IndicationNose
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2239 Asarum sieboldii 细辛 TCMH2239 ITSAI1576-14
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
TCMH1141 Schizonepeta tenuifolia 荆芥 TCMH1141 ITSAL858-14
TCMH562 Saposhnikovia divaricata 防风 TCMH562 ITSAE3225-14
TCMH118 Angelica dahurica 白芷 TCMH118 ITSAK3312-14
TCMH206 Fructus xanthii sibirici 苍耳子 TCMH206 KJ496390
TCMH981 Astragalus membranaceus 黄芪 TCMH981 ITSAK2981-14
TCMH120 Atractylodes macrocephala 白术 TCMH120 ITSAN4430-14
TCMH761 Cinnamomum cassia 桂枝 TCMH761 GQ255631
TCMH1920 Acorus tatarinowii 石菖蒲 TCMH1920 ITSAI4409-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT220 CYP2J2 Cytochrome P450 2J2 Oxidoreductase P51589
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT377 INSR Insulin receptor Kinase P06213
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT407 MYLK Myosin light chain kinase, smooth muscle Kinase Q15746
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT594 PTAFR Platelet activating factor receptor GPCR P25105
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT675 ADRB1 Beta-1 adrenergic receptor GPCR P08588
TCMT704 ERBB2 Receptor protein-tyrosine kinase erbB-2 Kinase P04626
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT778 KCNA5 Voltage-gated potassium channel subunit Kv1.5 Ion channel P22460
TCMT780 CACNA1D Voltage-gated L-type calcium channel alpha-1D subunit Ion channel Q01668
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1282 Colletotrichum orbiculare
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1319 Corynebacterium xerosis
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, ADRB1, AKR1B1, ALOX15, APP, BCL2, CA12, CA2, CA7, CACNA1C, CYP19A1, CYP1A1, CYP1B1, EGFR, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HMGCR, HSD17B1, HSPA1A, INSR, KDR, KIT, MET, PPARA, PTAFR, SLC1A1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 11.9656
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRB1, AKR1B1, ALOX15, APP, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, FLT3, GPR35, GRM1, HMGCR, HSPA1A, INSR, KDR, KIT, MET, MMP12, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 10.5895
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRB1, AKR1B1, ALOX15, APP, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, FLT3, GPR35, GRM1, HMGCR, HSPA1A, INSR, KDR, KIT, MET, MMP12, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 10.5895
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRB1, AKR1B1, ALOX15, APP, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ERBB2, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, NUAK1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 10.5895
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRB1, AKR1B1, ALOX15, APP, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ERBB2, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, NUAK1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 10.5071
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, PPARA, PTAFR, RORC, SMAD3, SRC, TEK 9.6939
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRB1, AKR1B1, ALOX15, APP, BCL2, CSNK2A1, CYP1B1, EGFR, ERBB2, FLT3, GPR35, GRM1, HMGCR, HSPA1A, INSR, KDR, KIT, MET, MMP12, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 9.06138
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRB1, ALOX15, APP, BCL2, DUSP3, EGFR, ERBB2, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, INSR, KDR, KIT, NUAK1, PPARA, PTAFR, SMAD3, SRC, TEK, XDH 8.66916
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRB1, ALOX15, APP, BCL2, DUSP3, EGFR, ERBB2, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, INSR, KDR, KIT, NUAK1, PPARA, PTAFR, SMAD3, SRC, TEK, XDH 8.62786
[BP] GO:0007215 None APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.62548
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, ALOX15, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, FABP3, FABP4, FUT7, HMGCR, HSD17B1, KIT, MET, PPARA 8.6149
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRB1, AKR1B1, ALOX15, APP, BCL2, CYP1B1, EGFR, ERBB2, FLT3, GPR35, GRM1, HMGCR, HSPA1A, INSR, KDR, KIT, MET, SRC, TEK, XDH 8.53839
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ERBB2, FABP3, FLT3, GRM5, IGF1R, INSR, KIT, PPARA, PTAFR, SMAD3, SRC, TEK 8.50931
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, ALOX15, ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, PPARA, PTAFR, RORC, SMAD3, SRC, TEK 8.43988
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, ALOX15, APP, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, GPR35, GRIK5, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, PPARA, PTAFR, SMAD3, SRC, TEK 7.8396
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, BCL2, CA1, CSNK2A1, EGFR, ERBB2, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, KIT, MET, PTAFR, SMAD3, SRC, TEK, TNKS, TNKS2 7.61709
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRB1, AKR1B1, ALOX15, APP, BCL2, CSNK2A1, CYP1B1, EGFR, ERBB2, FABP4, FLT3, GPR35, GRM1, HMGCR, HSPA1A, INSR, KDR, KIT, MET, MMP12, PTAFR, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 7.57337
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7, GRM5, PTAFR 7.18435
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.14488
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, BCL2, CSNK2A1, CYP1B1, EGFR, ERBB2, FABP3, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MMP12, NUAK1, PTAFR, SMAD3, SRC, TEK, XDH 7.14488
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, APP, BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, FABP4, FLT3, GRIK5, GRM5, HSPA1A, IGF1R, INSR, KDR, KIT, PTAFR, RORC, SMAD3, SRC 7.14488
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, APP, BCL2, CYP1A1, CYP1B1, EGFR, ERBB2, FABP4, FLT3, GRIK5, GRM5, IGF1R, INSR, KDR, KIT, PTAFR, RORC, SMAD3, SRC 7.08656
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRB1, AKR1B1, ALOX15, APP, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ERBB2, FLT3, GPR35, GRM1, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, SRC, TEK, XDH 7.02376
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRB1, ALOX15, APP, BCL2, EGFR, ERBB2, FABP3, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, KIT, PTAFR, SMAD3, SRC, TEK, XDH 7.01137
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRB1, ALOX15, APP, BCL2, EGFR, ERBB2, FABP3, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, KIT, PTAFR, SMAD3, SRC, TEK, XDH 7.01137
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, KIT 6.92896
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, KIT 6.92896
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, INSR, KIT, PPARA, PTAFR, SRC, TEK 6.91046
[BP] GO:0019748 secondary metabolic process AKR1B1, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.84731
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, BCL2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, GRIK5, GRM5, HMGCR, IGF1R, INSR, PPARA, PTAFR, RORC, SRC, TEK 6.84731
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, BCL2, CACNA1C, CYP19A1, CYP1B1, EGFR, ERBB2, IGF1R, INSR, KDR, KIT, MET, PTAFR, SMAD3, SRC, TEK 6.84731
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.71584
[BP] GO:0018108 peptidyl-tyrosine phosphorylation EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK 6.71584
[BP] GO:0018212 peptidyl-tyrosine modification EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK 6.66492
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, EGFR, ERBB2, IGF1R, INSR, KDR, KIT, MET, PTAFR, SMAD3, SRC, TEK 6.53499
[BP] GO:0046777 protein autophosphorylation CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, SRC, TEK 6.52719
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, APP, EGFR, ERBB2, FLT3, GRM1, HMGCR, INSR, KDR, KIT, SRC, TEK, XDH 6.50743
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, APP, DUSP3, EGFR, ERBB2, FLT3, GRM1, HMGCR, IGF1R, INSR, KDR, KIT, SRC, TEK, XDH 6.49428
[BP] GO:0042592 homeostatic process ADORA1, ADRB1, AKR1B1, APP, BCL2, CA12, CA2, CA7, CACNA1C, EGFR, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, INSR, MET, SMAD3, SRC 6.47097
[BP] GO:0044255 cellular lipid metabolic process ACHE, ALOX15, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, FABP3, FABP4, FUT7, HMGCR, KIT, MET, PPARA 6.43198
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, ADRB1, AKR1B1, ALOX15, APP, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ERBB2, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, PPARA, PTAFR, RORC, SLC1A1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 6.39539
[BP] GO:0044281 small molecule metabolic process AKR1B1, ALOX15, APP, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FUT7, HMGCR, HSPA1A, PPARA, PTAFR, XDH 6.23052
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 6.23052
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRB1, AKR1B1, ALOX15, APP, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ERBB2, FABP3, FLT3, GPR35, GRIK5, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, PPARA, PTAFR, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 6.22401
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, ADRB1, AKR1B1, ALOX15, APP, BCL2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ERBB2, FABP4, FLT3, GPR35, GRM1, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, NUAK1, PPARA, PTAFR, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 6.15961
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, EGFR, ERBB2, IGF1R, INSR, KDR, KIT, MET, PTAFR, SMAD3, SRC, TEK 6.11121
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, KIT, MET, PTAFR, SMAD3, SRC, TEK 6.11121
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, KIT, SRC 6.09682
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRB1, APP, BCL2, CSNK2A1, DUSP3, EGFR, ERBB2, FABP4, FLT3, GRM1, GRM3, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KIT, NUAK1, PTAFR, SMAD3, SRC, TEK, TNKS, XDH 5.95397
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APP, BCL2, CSNK2A1, DUSP3, EGFR, ERBB2, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PTAFR, PTPRS, SRC, TEK, TNKS, XDH 5.91945
[BP] GO:0048513 animal organ development ACHE, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ERBB2, FLT3, INSR, KDR, KIT, PPARA, PTPRS, SMAD3, SRC, TEK 5.91945
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRB1, AKR1B1, ALOX15, APP, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ERBB2, FLT3, GPR35, GRM1, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, NUAK1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 5.9031
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, CACNA1C, EGFR, FABP3, FABP4, GPR35, GRIK5, GRM1, GRM5, INSR, MET, SMAD3 5.78203
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.75502
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, EGFR, ERBB2, PPARA, SMAD3 5.74632
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA3, ADRB1, APP, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ERBB2, FABP4, FLT3, GPR35, GRM1, GRM3, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KIT, MET, NUAK1, PPARA, PTAFR, SMAD3, SRC, TEK, TNKS, XDH 5.71815
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, ALOX15, APP, BCL2, CA2, CA7, CACNA1C, CYP19A1, EGFR, ERBB2, GPR35, GRIK5, GRM5, HMGCR, HSPA1A, INSR, MMP12, PPARA, PTAFR, SMAD3, SRC 5.67034
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, PTAFR, RORC, SRC, TEK 5.64215
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APP, BCL2, CSNK2A1, DUSP3, EGFR, ERBB2, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PTAFR, PTPRS, SRC, TEK, TNKS, XDH 5.58277
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, ERBB2, FLT3, GRM1, HMGCR, IGF1R, INSR, KIT, SRC 5.52042
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.48938
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, APP, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, FABP4, FLT3, GRIK5, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, KIT, NUAK1, PTAFR, RORC, SMAD3, SRC 5.48938
[BP] GO:0009628 response to abiotic stimulus ADORA1, ADRB1, AKR1B1, APP, BCL2, CA2, CYP1A1, EGFR, GRM1, HMGCR, HSPA1A, KIT, PPARA, PTAFR, SMAD3, SRC, TEK 5.45668
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, EGFR, IGF1R, INSR, KDR, KIT, MET, PTAFR, SMAD3, SRC, TEK 5.38935
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, EGFR, IGF1R, INSR, KDR, KIT, MET, PTAFR, SMAD3, SRC, TEK 5.22869
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.16722
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRB1, ALOX15, APP, BCL2, CSNK2A1, EGFR, ERBB2, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, PPARA, PTAFR, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 5.16642
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, APP, BCL2, DUSP3, EGFR, ERBB2, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, KDR, KIT, PPARA, SRC, TEK, XDH 5.12141
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, EGFR, IGF1R, INSR, KDR, KIT, MET, PTAFR, SMAD3, SRC, TEK 5.11395
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.09367
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, EGFR, GRM1, GRM3, GRM5, GRM8 5.07452
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, APP, BCL2, EGFR, ERBB2, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, KIT, SRC, TEK, XDH 5.02339
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, APP, BCL2, DUSP3, EGFR, ERBB2, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, KDR, KIT, SRC, TEK, XDH 4.9965
[BP] GO:0006690 icosanoid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 4.9931
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, EGFR, IGF1R, INSR, KDR, KIT, MET, PTAFR, SMAD3, SRC, TEK 4.9765
[BP] GO:0042391 None ADORA1, APP, BCL2, CACNA1C, GPR35, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC 4.89311
[BP] GO:0032501 multicellular organismal process ADORA1, ADRB1, AKR1B1, ALOX15, ALPL, APP, BCL2, CACNA1C, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP4, GRM1, GRM5, GRM8, HMGCR, IGF1R, INSR, KIT, MET, MMP12, PPARA, PTAFR, RORC, SMAD3, SRC, TEK, TNKS2 4.89311
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRB1, ALOX15, APP, BCL2, EGFR, ERBB2, FABP3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, PPARA, PTAFR, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 4.86978
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRB1, AKR1B1, APP, BCL2, CA1, CA2, CACNA1C, CSNK2A1, CYP1B1, EGFR, ERBB2, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, KIT, MET, NUAK1, PPARA, PTAFR, RORC, SMAD3, SRC, TEK, TNKS, TNKS2 4.86145
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, DUSP3, EGFR, ERBB2, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, KIT, SRC, TEK 4.86145
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRB1, APP, BCL2, CA2, CACNA1C, CYP1B1, EGFR, ERBB2, GPR35, GRM1, HMGCR, HSPA1A, INSR, KDR, KIT, MET, MMP12, PTAFR, PTPRS, SLC1A1, SMAD3, SRC, TEK, TNKS2, XDH 4.81298
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, APP, BCL2, EGFR, ERBB2, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, KIT, SRC, TEK, XDH 4.81221
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRB1, ALOX15, APP, BCL2, CSNK2A1, EGFR, ERBB2, FABP3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, PPARA, PTAFR, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 4.78204
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, ALOX15, ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MMP12, NUAK1, PPARA, PTAFR, RORC, SMAD3, SRC, TEK 4.75215
[BP] GO:0031399 regulation of protein modification process ADORA1, ALOX15, APP, BCL2, DUSP3, EGFR, ERBB2, FABP4, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, NUAK1, SRC, TEK, XDH 4.74951
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, SLC1A1 4.74146
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.72501
[BP] GO:0008202 steroid metabolic process AKR1B1, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, HMGCR, HSD17B1 4.71943
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, APP, BCL2, CSNK2A1, EGFR, ERBB2, FLT3, GRM1, GRM5, HMGCR, HSPA1A, INSR, KDR, KIT, PTAFR, SMAD3, SRC, TEK, XDH 4.69629
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, DUSP3, EGFR, ERBB2, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, KIT, SRC, TEK, TNKS 4.69219
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, APP, CYP19A1, DUSP3, EGFR, FABP4, HMGCR, HSPA1A, IGF1R, MET, MMP12, NUAK1, PPARA, PTPRS, SMAD3, SRC, TEK, XDH 4.68361
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.6244
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, DUSP3, EGFR, ERBB2, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, KIT, SRC 4.47254
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRB1, AKR1B1, ALOX15, ALPL, APP, BCL2, CA2, CA9, CACNA1C, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ERBB2, FABP4, FLT3, FUT7, HMGCR, INSR, KDR, KIT, MET, PPARA, PTPRS, RORC, SMAD3, SRC, TEK, TNKS2 4.47254
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ALOX15, APP, BCL2, EGFR, ERBB2, FLT3, GRM1, GRM5, HMGCR, HSPA1A, INSR, KDR, KIT, PTAFR, SMAD3, SRC, TEK, XDH 4.39234
[BP] GO:0006468 protein phosphorylation APP, BCL2, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, SRC, TEK, TNKS 4.37801
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, DUSP3, EGFR, ERBB2, HMGCR, KDR, SRC, TEK 4.3763
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, HMGCR, KIT, PPARA, RORC, SRC, TEK 4.3643
[BP] GO:0044070 regulation of anion transport ABCB1, ADORA1, CA2, CA7, GRM5, PTAFR 4.34098
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC, TEK 4.3405
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, BCL2, CSNK2A1, EGFR, HMGCR, HSPA1A, IGF1R, KDR, KIT, MET, PPARA, SMAD3, SRC, TEK 4.30653
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, APP, BCL2, CSNK2A1, EGFR, ERBB2, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, PPARA, PTAFR, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 4.29544
[BP] GO:0032844 regulation of homeostatic process ADORA1, BCL2, CA2, CA7, CACNA1C, EGFR, HMGCR, KDR, SRC, TNKS, TNKS2 4.25862
[BP] GO:0044093 positive regulation of molecular function ABCB1, ADORA1, ADRB1, APP, BCL2, EGFR, ERBB2, FLT3, GRM1, GRM5, HSPA1A, INSR, KIT, MET, PTAFR, SMAD3, SRC, TEK, TNKS, XDH 4.24046
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRB1, APP, BCL2, EGFR, ERBB2, FLT3, GRM1, GRM5, HSPA1A, INSR, KIT, PTAFR, SMAD3, SRC, TEK, TNKS, XDH 4.20624
[BP] GO:0051896 regulation of protein kinase B signaling EGFR, ERBB2, INSR, KIT, MET, SRC, TEK, XDH 4.19473
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 4.17443
[BP] GO:0033993 response to lipid ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, FABP3, FLT3, PTAFR, RORC, SRC 4.14662
[BP] GO:0006631 fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA 4.14244
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DUSP3, EGFR, ERBB2, FLT3, GRM1, HMGCR, IGF1R, INSR, KIT, SRC 4.04047
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, BCL2, CSNK2A1, EGFR, HMGCR, HSPA1A, IGF1R, KDR, KIT, MET, SMAD3, SRC, TEK 4.03692
[BP] GO:0051897 positive regulation of protein kinase B signaling EGFR, ERBB2, INSR, KIT, MET, SRC, TEK 4.0354
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, GRIK5, HMGCR, HSPA1A, IGF1R, KDR, KIT, MET, PPARA, SMAD3, SRC, TEK, XDH 4.00987
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 3.98976
[BP] GO:0003018 None ADORA1, ADRB1, EGFR, HMGCR, PTAFR, SRC, TEK 3.98976
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX15, BCL2, CYP19A1, DUSP3, EGFR, ERBB2, HMGCR, HSPA1A, IGF1R, MET, MMP12, PPARA, PTPRS, SMAD3, SRC, TEK, XDH 3.96277
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CSNK2A1, EGFR, ERBB2, FLT3, HMGCR, IGF1R, INSR, KDR, KIT, MMP12, PTAFR, TEK 3.96277
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, ALOX15, APP, BCL2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ERBB2, FABP3, FABP4, GPR35, GRM3, GRM8, HMGCR, HSPA1A, IGF1R, KDR, KIT, MET, MMP12, PPARA, PTPRS, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 3.94454
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APP, BCL2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ERBB2, FABP3, FABP4, GPR35, GRM3, GRM8, HMGCR, HSPA1A, IGF1R, KDR, KIT, MET, MMP12, PPARA, PTPRS, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 3.94454
[BP] GO:0044057 None ADORA1, ADORA3, ADRB1, CACNA1C, EGFR, GPR35, GRM1, KIT, PTAFR, SLC1A1, SMAD3 3.93857
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ERBB2, FLT3, INSR, KDR, KIT, PPARA, PTPRS, RORC, SMAD3, SRC, TEK 3.92231
[BP] GO:0010038 response to metal ion ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, KIT 3.91471
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, GRIK5, HMGCR, HSPA1A, IGF1R, KDR, KIT, MET, SMAD3, SRC, TEK, XDH 3.84042
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.81484
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.81484
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, APP, BCL2, EGFR, ERBB2, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, KIT, SRC, TEK, XDH 3.81319
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, SLC1A1 3.75552
[BP] GO:0050801 ion homeostasis APP, BCL2, CA12, CA2, CA7, CACNA1C, EGFR, FABP3, GPR35, GRM1, GRM5, SMAD3 3.7244
[BP] GO:0030155 regulation of cell adhesion ALOX15, BCL2, CYP1B1, DUSP3, ERBB2, KDR, NUAK1, PPARA, PTAFR, SMAD3, SRC, TEK 3.7244
[BP] GO:0035235 None APP, GRIA2, GRIA4, GRIK5 3.7244
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ALOX15, APP, BCL2, CSNK2A1, DUSP3, EGFR, ERBB2, FABP4, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, NUAK1, PTAFR, SMAD3, SRC, TEK, XDH 3.67181
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, EGFR, ERBB2, FLT3, GRM5, IGF1R, INSR, KIT, PTAFR, SMAD3, SRC 3.64017
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, GRM5, IGF1R, INSR, PPARA, SRC, TEK 3.62903
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, CYP1A1, CYP1B1, EGFR, FLT3, PTAFR, RORC, SRC 3.61116
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, ADORA1, APP, BCL2, CA2, CYP19A1, EGFR, ERBB2, INSR, MMP12, PTAFR, SMAD3, SRC 3.58034
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, ERBB2, FLT3, GRM1, INSR, KIT, SRC 3.55978
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, DUSP3, EGFR, ERBB2, GPR35, HMGCR, HSPA1A, IGF1R, MET, MMP12, PTPRS, SMAD3, SRC, XDH 3.50754
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC, TEK 3.4949
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, DUSP3, EGFR, ERBB2, GPR35, HMGCR, HSPA1A, IGF1R, MET, MMP12, PTPRS, SMAD3, SRC, XDH 3.4949
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, ALOX15, ALPL, APP, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CACNA1C, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ERBB2, FABP3, FABP4, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, NUAK1, PPARA, PTAFR, PTPRS, RORC, SLC1A1, SMAD3, SRC, TEK, TNKS, TNKS2, TUBB3, XDH 3.48468
[BP] GO:0010359 None ABCB1, GRM5, PTAFR 3.48453
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, KIT, PPARA, SRC, TEK 3.4505
[BP] GO:0016310 phosphorylation APP, BCL2, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, SRC, TEK, TNKS 3.40432
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, APP, EGFR, HMGCR, KDR, SRC, TEK 3.387
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC, TEK 3.37108
[BP] GO:0042493 response to drug ABCB1, AKR1B1, BCL2, CA9, CYP1A1, CYP1B1, EGFR, FABP3, HMGCR, KDR, PTAFR, SRC 3.35478
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.35478
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, KIT, SRC, TEK 3.35478
[BP] GO:0018193 peptidyl-amino acid modification BCL2, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK, TNKS 3.32877
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRB1, ALOX15, APP, BCL2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ERBB2, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, NUAK1, PPARA, PTAFR, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 3.32877
[BP] GO:0010638 positive regulation of organelle organization ALOX15, BCL2, HSPA1A, INSR, KDR, MET, SMAD3, SRC, TEK, TNKS, TNKS2 3.31984
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK 3.30702
[BP] GO:0003013 None ADORA1, ADRB1, EGFR, HMGCR, PTAFR, SRC, TEK 3.30452
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRB1, ALOX15, APP, BCL2, CA9, CSNK2A1, CYP1A1, CYP1B1, DUSP3, EGFR, ERBB2, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, NUAK1, PPARA, PTAFR, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 3.29751
[BP] GO:0007193 None ADORA1, GRM1, GRM3, GRM5, GRM8 3.28345
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, CACNA1C, KDR, SRC 3.26944
[BP] GO:0042060 None ALOX15, EGFR, ERBB2, PPARA, SMAD3 3.26175
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5 3.26175
[BP] GO:0035556 intracellular signal transduction ADRB1, AKR1B1, BCL2, CACNA1C, CYP1B1, EGFR, ERBB2, GRM5, IGF1R, INSR, KDR, KIT, MET, NUAK1, PTAFR, SRC, TEK 3.25366
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 3.25134
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CACNA1C, CYP19A1, CYP1A1, CYP1B1, EGFR, HMGCR, HSD17B1 3.25017
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, PPARA, PTAFR, SRC, TEK 3.24685
[BP] GO:0051240 positive regulation of multicellular organismal process ADRB1, APP, BCL2, CA2, CYP1B1, EGFR, HMGCR, HSPA1A, KDR, KIT, MET, MMP12, PTAFR, SLC1A1, SMAD3, SRC, TEK 3.23542
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, EGFR, ERBB2, FABP3, FABP4, KIT, MET 3.20227
[BP] GO:0098771 inorganic ion homeostasis APP, BCL2, CA12, CA2, CA7, CACNA1C, EGFR, GPR35, GRM1, GRM5, SMAD3 3.17667
[BP] GO:0003008 None ADORA1, ADRB1, AKR1B1, APP, BCL2, CYP1B1, EGFR, GRM1, GRM5, GRM8, HMGCR, INSR, KIT, PTAFR, SRC, TEK 3.15774
[BP] GO:0051246 regulation of protein metabolic process ADORA1, ALOX15, APP, BCL2, CSNK2A1, DUSP3, EGFR, ERBB2, FABP4, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, NUAK1, PTAFR, SMAD3, SRC, TEK, XDH 3.1475
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, EGFR, FLT3, PTAFR, SRC 3.1475
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, EGFR, FABP4, HMGCR, KDR, MET, MMP12, PPARA, PTPRS, SMAD3, TEK 3.13089
[BP] GO:0032845 None ADORA1, BCL2, HMGCR, SRC, TNKS, TNKS2 3.13089
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, HMGCR, PTAFR 3.13089
[BP] GO:0040008 regulation of growth ADRB1, APP, BCL2, CSNK2A1, EGFR, ERBB2, HSPA1A, INSR, PTPRS, SMAD3, TNKS2 3.12304
[BP] GO:0008283 cell proliferation ABCB1, ACHE, BCL2, CYP1A1, EGFR, ERBB2, FLT3, KIT, MET, SRC, TEK 3.11874
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ADRB1, ALOX15, APP, BCL2, CA9, CSNK2A1, CYP1B1, DUSP3, EGFR, ERBB2, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, NUAK1, PPARA, PTAFR, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 3.11179
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ADRB1, ALOX15, APP, BCL2, CA9, CSNK2A1, CYP1B1, DUSP3, EGFR, ERBB2, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, NUAK1, PPARA, PTAFR, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 3.06323
[BP] GO:0050730 None ADORA1, APP, EGFR, FLT3, GRM5, KIT, SRC 3.01794
[BP] GO:0033674 positive regulation of kinase activity ADORA1, EGFR, ERBB2, FLT3, GRM1, GRM5, INSR, KIT, SRC, TEK 3.00931
[BP] GO:0007167 enzyme linked receptor protein signaling pathway EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MET, SMAD3, SRC, TEK 3.00931
[BP] GO:0045776 None ADORA1, ADRB1, PPARA, PTAFR 3.00537
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, PTAFR, SRC 2.97677
[BP] GO:0043551 regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC, TEK 2.96963
[BP] GO:0007188 None ADORA1, ADRB1, GRM1, GRM3, GRM5, GRM8 2.96455
[BP] GO:0008152 metabolic process ACHE, ADORA1, ADRB1, AKR1B1, ALOX15, ALPL, APP, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ERBB2, FABP3, FABP4, FLT3, FUT7, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, NUAK1, PPARA, PTAFR, PTPRS, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 2.96334
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, PPARA, PTAFR, SRC, TEK 2.96334
[BP] GO:0051347 positive regulation of transferase activity ADORA1, EGFR, ERBB2, FLT3, GRM1, GRM5, INSR, KIT, SRC, TEK, TNKS 2.96211
[BP] GO:0051701 interaction with host EGFR, HSPA1A, INSR, MET, SMAD3, SRC 2.94215
[BP] GO:0006811 None ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, FABP3, GRIA2, GRIA4, GRIK5, PPARA, SLC1A1 2.88146
[BP] GO:0071363 cellular response to growth factor stimulus APP, EGFR, ERBB2, INSR, KDR, SMAD3, SRC 2.88001
[BP] GO:0014066 regulation of phosphatidylinositol 3-kinase signaling EGFR, FLT3, KDR, KIT, TEK 2.84174
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, EGFR, ERBB2, FLT3, GRM1, INSR, KIT, SRC 2.80056
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, BCL2, CSNK2A1, EGFR, HMGCR, HSPA1A, IGF1R, KDR, SMAD3, SRC, TEK 2.80056
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, INSR, SMAD3, XDH 2.78859
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, CSNK2A1, CYP1B1, DUSP3, FABP4, GPR35, GRM3, HMGCR, IGF1R, MET, PPARA, SRC, TNKS 2.78048
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, EGFR, GRIK5, INSR, SLC1A1, SMAD3 2.78033
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, GRIK5, HMGCR, HSPA1A, IGF1R, KDR, SMAD3, SRC, TEK, XDH 2.77703
[BP] GO:0065007 biological regulation ABCB1, ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, ALOX15, APP, BCL2, CA1, CA12, CA2, CA7, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ERBB2, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, NUAK1, PPARA, PTAFR, PTPRS, RORC, SLC1A1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 2.77386
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, MMP12, PPARA, SMAD3, TEK 2.76912
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, BCL2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, SMAD3, SRC, TEK, TNKS, TNKS2 2.76912
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, ALOX15, ALPL, APP, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ERBB2, FABP3, FABP4, FLT3, FUT7, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PPARA, PTAFR, PTPRS, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 2.76912
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 2.7567
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, PPARA, SMAD3, SRC, TEK 2.74891
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, KDR, SMAD3, SRC, TEK 2.73957
[BP] GO:0032787 None ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA 2.69859
[BP] GO:0010676 None INSR, PPARA, PTAFR, SRC 2.68523
[BP] GO:0043550 regulation of lipid kinase activity FLT3, KIT, SRC, TEK 2.68523
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, EGFR, PTAFR, SRC 2.68523
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, PPARA, SMAD3, SRC, TEK 2.67456
[BP] GO:0043269 regulation of ion transport ABCB1, ADORA1, APP, BCL2, CA2, CA7, CACNA1C, GPR35, GRM5, PTAFR 2.67456
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1 2.65172
[BP] GO:0050789 regulation of biological process ABCB1, ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, ALOX15, APP, BCL2, CA1, CA2, CA7, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ERBB2, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, NUAK1, PPARA, PTAFR, PTPRS, RORC, SLC1A1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 2.64575
[BP] GO:0055114 oxidation-reduction process AKR1B1, ALOX15, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HMGCR, HSD17B1, XDH 2.63732
[BP] GO:0050890 None ADORA1, APP, EGFR, GRM5, HMGCR, INSR, KIT 2.63475
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.63475
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.63475
[BP] GO:0007187 None ADORA1, ADRB1, GRM1, GRM3, GRM5, GRM8 2.63384
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, CYP1B1, EGFR, GRIK5, GRM5, IGF1R, INSR, PTAFR, RORC, SRC 2.63277
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1 2.61502
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, ALOX15, APP, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, HSPA1A, KIT, NUAK1, PPARA, PTAFR, SMAD3, SRC, TEK 2.61502
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.61502
[BP] GO:0099566 None GRM1, GRM5 2.61462
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.61462
[BP] GO:0002520 None CACNA1C, SMAD3 2.61462
[BP] GO:0055080 cation homeostasis APP, BCL2, CA2, CA7, CACNA1C, EGFR, GPR35, GRM1, GRM5, SMAD3 2.59011
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, BCL2, KDR, SMAD3, SRC, TEK 2.59011
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CYP19A1, HMGCR, PPARA, PTPRS, SMAD3, TEK 2.59011
[BP] GO:0070848 response to growth factor APP, EGFR, ERBB2, INSR, KDR, SMAD3, SRC 2.59011
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, EGFR, TEK 2.57644
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, RORC 2.57644
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.57089
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, EGFR, MET, SMAD3, SRC 2.5669
[BP] GO:0035588 None ADORA1, ADORA3, PTAFR 2.56686
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, SMAD3, TEK 2.56421
[BP] GO:0048511 rhythmic process BCL2, CSNK2A1, EGFR, KIT, PPARA, RORC, SRC 2.55186
[BP] GO:0007423 None BCL2, CACNA1C, CYP1A1, EGFR, KIT 2.54912
[BP] GO:1903522 None ADORA1, ADORA3, ADRB1, CACNA1C, EGFR, PTAFR, SLC1A1 2.54512
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, EGFR, ERBB2, FLT3, GRM1, GRM5, INSR, KIT, SRC 2.52374
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, EGFR, GRM5, IGF1R, INSR, PTAFR, SRC 2.52374
[BP] GO:1903959 None ABCB1, GRM5, PTAFR 2.51704
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, FABP4, HSPA1A, MMP12, PPARA, PTPRS, SMAD3, SRC, TEK 2.50511
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, PPARA, SMAD3, SRC, TEK 2.50079
[BP] GO:0080135 regulation of cellular response to stress APP, DUSP3, EGFR, HMGCR, HSPA1A, IGF1R, MET, NUAK1, PTPRS, XDH 2.49904
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, EGFR 2.48499
[BP] GO:0010675 None INSR, PPARA, PTAFR, RORC, SRC 2.48499
[BP] GO:0055082 cellular chemical homeostasis APP, BCL2, CA2, CA7, CACNA1C, GPR35, GRIK5, GRM1, GRM5, SMAD3 2.48499
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, BCL2, CYP1A1, CYP1B1, HMGCR, KDR, SRC 2.48499
[BP] GO:0009891 positive regulation of biosynthetic process ADRB1, APP, EGFR, ERBB2, FABP3, IGF1R, INSR, KDR, MET, MMP12, PPARA, PTAFR, RORC, SMAD3, SRC, TNKS, TNKS2 2.47613
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, EGFR, HSPA1A 2.45288
[BP] GO:0097746 None ADORA1, ADRB1, EGFR, HMGCR, PTAFR 2.44047
[BP] GO:0035296 None ADORA1, ADRB1, EGFR, HMGCR, PTAFR 2.44047
[BP] GO:0006720 isoprenoid metabolic process CYP1A1, CYP1A2, CYP1B1, EGFR, HMGCR 2.4252
[BP] GO:0048869 cellular developmental process ACHE, ADRB1, ALPL, APP, BCL2, CBR1, CYP1A1, EGFR, ERBB2, FABP4, FLT3, FUT7, HMGCR, KDR, KIT, MET, PTPRS, RORC, SMAD3, SRC, TEK 2.41711
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.41711
[BP] GO:0090087 None ACHE, ADORA1, APP, CA2, CACNA1C, EGFR, ERBB2, HMGCR, MMP12, SMAD3, SRC 2.40629
[BP] GO:1901653 cellular response to peptide AKR1B1, APP, GRM5, IGF1R, INSR, SRC 2.3968
[BP] GO:0007610 None APP, BCL2, EGFR, GRM1, GRM5, HMGCR, INSR, KIT, PPARA 2.38995
[BP] GO:0072507 divalent inorganic cation homeostasis APP, BCL2, CACNA1C, EGFR, GPR35, GRM1, GRM5, SMAD3 2.383
[BP] GO:0050793 regulation of developmental process ADRB1, APP, BCL2, CA2, CYP1B1, EGFR, ERBB2, HMGCR, INSR, KDR, KIT, NUAK1, PPARA, PTPRS, RORC, SMAD3, SRC, TEK, TNKS2, XDH 2.383
[BP] GO:0070213 None TNKS, TNKS2 2.383
[BP] GO:1901529 None ABCB1, PTAFR 2.383
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.383
[BP] GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling FLT3, KDR, KIT, TEK 2.38145
[BP] GO:0051894 None KDR, SMAD3, TEK 2.38145
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1 2.38145
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.38145
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CACNA1C, CYP19A1, EGFR, GRIK5, HMGCR, MMP12, PTAFR, SRC 2.36161
[BP] GO:0051054 positive regulation of DNA metabolic process EGFR, IGF1R, INSR, SRC, TNKS, TNKS2 2.36161
[BP] GO:0040014 regulation of multicellular organism growth ADRB1, APP, BCL2, TNKS2 2.36161
[BP] GO:0050880 None ADORA1, ADRB1, EGFR, HMGCR, PTAFR 2.3431
[BP] GO:0032872 regulation of stress-activated MAPK cascade APP, DUSP3, EGFR, HMGCR, IGF1R, XDH 2.34216
[BP] GO:0045913 None INSR, PPARA, PTAFR, SRC 2.34017
[BP] GO:0048169 None APP, GRM5, KIT 2.33862
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APP, EGFR, GRM5, IGF1R, INSR, PTAFR, SRC 2.33862
[BP] GO:0070302 regulation of stress-activated protein kinase signaling cascade APP, DUSP3, EGFR, HMGCR, IGF1R, XDH 2.33862
[BP] GO:0035150 None ADORA1, ADRB1, EGFR, HMGCR, PTAFR 2.33767
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5 2.32537
[BP] GO:0031644 None ADORA1, GPR35, GRM1, PTAFR 2.30363
[BP] GO:1903524 None ADRB1, EGFR, PTAFR, SLC1A1 2.30363
[BP] GO:0007612 None APP, GRM5, HMGCR, INSR, KIT 2.30363
[BP] GO:0023052 None ADORA1, ADRB1, CACNA1C, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, TEK 2.30363
[BP] GO:1903393 None KDR, SMAD3, TEK 2.30363
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, BCL2, CYP1B1, ERBB2, FABP3, HSPA1A, SMAD3, XDH 2.27976
[BP] GO:0034762 None ABCB1, APP, BCL2, CA2, CACNA1C, GPR35, GRM5, PTAFR 2.27976
[BP] GO:0030003 cellular cation homeostasis APP, BCL2, CA2, CA7, CACNA1C, GPR35, GRM1, GRM5, SMAD3 2.27614
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, EGFR, FLT3, PTAFR 2.26649
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.26425
[BP] GO:1904646 cellular response to amyloid-beta APP, GRM5, IGF1R 2.26425
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, APP, BCL2, CA2, CYP19A1, DUSP3, ERBB2, HSPA1A, KIT, MMP12, PTAFR, PTPRS, SMAD3, SRC 2.26077
[BP] GO:0050678 None EGFR, ERBB2, KDR, MMP12, SMAD3, TEK, XDH 2.24072
[BP] GO:0022898 None ABCB1, APP, BCL2, GPR35, GRM5, PTAFR 2.23724
[BP] GO:0009968 negative regulation of signal transduction BCL2, DUSP3, EGFR, ERBB2, HMGCR, HSPA1A, IGF1R, MET, MMP12, PTPRS, SMAD3, SRC, XDH 2.23547
[BP] GO:0035587 None ADORA1, ADORA3, PTAFR 2.22316
[BP] GO:0051128 regulation of cellular component organization ALOX15, APP, BCL2, CSNK2A1, EGFR, ERBB2, GRIK5, HSPA1A, IGF1R, INSR, KDR, KIT, MET, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2 2.2189
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.2189
[BP] GO:0006873 cellular ion homeostasis APP, BCL2, CA2, CA7, CACNA1C, GPR35, GRM1, GRM5, SMAD3 2.21481
[BP] GO:0007154 None ADORA1, ADRB1, BCL2, CACNA1C, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, TEK 2.21481
[BP] GO:0006650 glycerophospholipid metabolic process ACHE, ALOX15, CSNK2A1, EGFR, ERBB2, KIT, MET 2.20372
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, PTAFR 2.19714
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, ALOX15, APP, BCL2, CA1, CA2, CA7, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ERBB2, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, NUAK1, PPARA, PTAFR, PTPRS, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 2.18413
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APP, BCL2, CSNK2A1, DUSP3, EGFR, FABP4, GRM3, GRM8, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP12, PPARA, RORC, SMAD3, SRC, TNKS, TNKS2, XDH 2.18413
[BP] GO:0007611 None APP, EGFR, GRM5, HMGCR, INSR, KIT 2.1803
[BP] GO:0046427 positive regulation of JAK-STAT cascade AKR1B1, CYP1B1, FLT3, KIT 2.17959
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4 2.16249
[BP] GO:0051046 None ACHE, ADORA1, CACNA1C, CYP19A1, EGFR, GRIK5, HMGCR, MMP12, PTAFR, SRC 2.15954
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, BCL2, CYP1B1, EGFR, HSPA1A, SRC 2.15954
[BP] GO:0051098 regulation of binding APP, BCL2, MET, PPARA, SMAD3, SRC, TNKS 2.15954
[BP] GO:0008217 None ADORA1, ADRB1, PPARA, PTAFR, SMAD3 2.15437
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.15363
[BP] GO:1904645 response to amyloid-beta APP, GRM5, IGF1R 2.15363
[BP] GO:0019637 organophosphate metabolic process ACHE, ALOX15, CSNK2A1, EGFR, ERBB2, HMGCR, HSPA1A, KIT, MET, PTAFR, XDH 2.14895
[BP] GO:1904894 positive regulation of STAT cascade AKR1B1, CYP1B1, FLT3, KIT 2.14747
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, SMAD3 2.12522
[BP] GO:0032409 None ABCB1, APP, BCL2, GPR35, GRM5, PTAFR 2.12522
[BP] GO:1901890 None KDR, SMAD3, TEK 2.11705
[BP] GO:0009889 regulation of biosynthetic process ADORA3, ADRB1, APP, BCL2, CA9, CSNK2A1, CYP1B1, EGFR, ERBB2, FABP3, FABP4, GRM3, GRM5, GRM8, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, PPARA, PTAFR, RORC, SMAD3, SRC, TNKS, TNKS2 2.11506
[BP] GO:0031328 positive regulation of cellular biosynthetic process ADRB1, APP, EGFR, ERBB2, FABP3, IGF1R, INSR, MET, MMP12, PPARA, PTAFR, RORC, SMAD3, SRC, TNKS, TNKS2 2.1076
[BP] GO:1901888 regulation of cell junction assembly KDR, SMAD3, SRC, TEK 2.0934
[BP] GO:0048729 tissue morphogenesis BCL2, CA2, CA9, EGFR, MET, SMAD3, SRC 2.08381
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7 2.08353
[BP] GO:0001816 cytokine production APP, FABP4, KIT, PTAFR 2.08353
[BP] GO:0051902 negative regulation of mitochondrial depolarization BCL2, SRC 2.08353
[BP] GO:1990535 None APP, INSR 2.08353
[BP] GO:1903961 None ABCB1, PTAFR 2.08353
[BP] GO:1904306 None KIT, PTAFR 2.08353
[BP] GO:1904304 None KIT, PTAFR 2.08353
[BP] GO:0051234 None ABCB1, ACHE, ADORA1, ALOX15, APP, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, EGFR, FABP3, GRIA2, GRIA4, GRIK5, HSPA1A, KIT, MMP12, PPARA, PTAFR, SLC1A1, SRC, TNKS, XDH 2.05752
[BP] GO:0010863 positive regulation of phospholipase C activity EGFR, KIT, PTAFR 2.05523
[BP] GO:0010907 None INSR, PPARA, SRC 2.05523
[BP] GO:0106027 None APP, IGF1R, INSR 2.05523
[BP] GO:0044089 positive regulation of cellular component biogenesis ALOX15, HSPA1A, KDR, KIT, MET, SMAD3, SRC, TEK 2.04072
[BP] GO:0051930 None ADORA1, GRM1, PTAFR 2.02027
[BP] GO:0051931 None ADORA1, GRM1, PTAFR 2.02027
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX15, CYP19A1, HMGCR, PTAFR 2.01979
[BP] GO:0007267 None ADORA1, ADRB1, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, TEK 2.01671
[CC] GO:0044459 plasma membrane part ABCB1, ADORA1, ADORA3, ADRB1, ALOX15, APP, CA2, CA4, CA9, CACNA1C, DUSP3, EGFR, ERBB2, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, KIT, MET, PTAFR, PTPRS, SLC1A1, SRC, TEK 8.42109
[CC] GO:0098590 plasma membrane region ABCB1, ADORA1, CA2, CA4, CA9, EGFR, ERBB2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, INSR, MET, SLC1A1, SRC, TEK 7.00703
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA1, ADORA3, ADRB1, ALOX15, ALPL, APP, CA12, CA14, CA2, CA4, CA9, CACNA1C, CSNK2A1, EGFR, ERBB2, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, KIT, MET, PTAFR, PTPRS, SLC1A1, SMAD3, SRC, TEK 6.48514
[CC] GO:0044425 membrane part ABCB1, ACHE, ADORA1, ADORA3, ADRB1, ALOX15, ALPL, APP, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ERBB2, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, INSR, KDR, KIT, MET, PTAFR, PTPRS, SLC1A1, SRC, TEK 5.91945
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA1, ADORA3, ADRB1, ALOX15, ALPL, APP, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, INSR, KDR, KIT, MET, PTAFR, PTPRS, SLC1A1, SMAD3, SRC, TEK, TNKS, TNKS2 5.6661
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRB1, APP, CA4, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, PTAFR, PTPRS, SLC1A1, TEK 5.283
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRB1, APP, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, PTAFR, PTPRS, SLC1A1, TEK 4.89311
[CC] GO:0043235 receptor complex APP, EGFR, ERBB2, GRIA2, GRIA4, GRIK5, GRM1, IGF1R, INSR, SMAD3 4.78204
[CC] GO:0044456 None ACHE, ADORA1, APP, CACNA1C, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, PTPRS, SRC 4.29916
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.6468
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, ERBB2, TEK 3.52865
[CC] GO:0014069 None ADORA1, CACNA1C, GRIK5, GRM1, GRM3, GRM5, SRC 3.37728
[CC] GO:0099572 None ADORA1, CACNA1C, GRIK5, GRM1, GRM3, GRM5, SRC 3.37728
[CC] GO:0043005 None ADORA1, APP, CA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PTPRS, SRC, TUBB3 3.0886
[CC] GO:0097458 None ADORA1, APP, CA2, CACNA1C, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, INSR, PTPRS, SRC, TUBB3 2.59011
[CC] GO:0097060 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 2.52878
[CC] GO:0043197 None ADORA1, APP, GRIA2, GRIA4, GRM3 2.52374
[CC] GO:0044309 None ADORA1, APP, GRIA2, GRIA4, GRM3 2.49594
[CC] GO:0120025 None ADORA1, AKR1B1, APP, CA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PTPRS, SRC, TEK, TUBB3 2.36378
[CC] GO:0031224 None ABCB1, ACHE, ADORA1, ADORA3, ADRB1, ALPL, APP, CA12, CA14, CA4, CA9, CACNA1C, EGFR, ERBB2, FLT3, FUT7, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, INSR, KDR, KIT, MET, PTAFR, PTPRS, SLC1A1, TEK 2.30363
[CC] GO:0042995 cell projection ADORA1, AKR1B1, APP, CA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PTPRS, SRC, TEK, TUBB3 2.16227
[CC] GO:0098794 None ADORA1, APP, GRIA2, GRIA4, GRM3 2.12149
[CC] GO:0044464 cell part ABCB1, ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, ALOX15, ALPL, APP, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ERBB2, FABP3, FABP4, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, NUAK1, PPARA, PTAFR, PTPRS, RORC, SLC1A1, SMAD3, SRC, TEK, TNKS, TNKS2, TUBB3, XDH 2.08588
[CC] GO:0043226 organelle ABCB1, ACHE, ADORA1, ADRB1, AKR1B1, ALOX15, ALPL, APP, BCL2, CA1, CA2, CA4, CA9, CACNA1C, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ERBB2, FABP3, FABP4, FLT3, FUT7, GRIA4, GRIK5, GRM1, GRM3, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MMP12, NUAK1, PPARA, PTPRS, RORC, SLC1A1, SMAD3, SRC, TNKS, TNKS2, TUBB3, XDH 2.03307
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.1961
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MET, TEK 9.00565
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.49539
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX15, ALPL, APP, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, NUAK1, PPARA, PTAFR, PTPRS, RORC, SLC1A1, SMAD3, SRC, TEK, TNKS, TNKS2, TUBB3, XDH 8.39417
[MF] GO:0019199 transmembrane receptor protein kinase activity EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MET, TEK 8.36481
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRB1, EGFR, ERBB2, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, KIT, MET, PPARA, PTAFR, RORC, TEK 7.69396
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, ERBB2, INSR, KDR, KIT 7.46726
[MF] GO:0046914 transition metal ion binding ALOX15, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MMP12, PPARA, RORC, SMAD3, TNKS, XDH 7.1522
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRB1, EGFR, ERBB2, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, KIT, MET, PTAFR, TEK 6.93676
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRB1, EGFR, ERBB2, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, KIT, MET, PTAFR, TEK 6.93676
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.92896
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRB1, EGFR, ERBB2, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, KIT, MET, PPARA, PTAFR, RORC, TEK 6.91046
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRB1, EGFR, ERBB2, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, KIT, MET, PPARA, PTAFR, RORC, SMAD3, TEK 6.88975
[MF] GO:0004713 protein tyrosine kinase activity EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK 6.80486
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRB1, EGFR, ERBB2, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, KIT, MET, PPARA, PTAFR, RORC, TEK 6.71584
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.67083
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, ALOX15, ALPL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ERBB2, FLT3, FUT7, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, NUAK1, PTPRS, SRC, TEK, TNKS, TNKS2, TUBB3, XDH 6.43644
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.86418
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 5.57703
[MF] GO:0005506 iron ion binding ALOX15, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, XDH 4.9765
[MF] GO:0008144 drug binding ABCB1, ACHE, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, EGFR, ERBB2, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PPARA, SRC, TEK 4.89311
[MF] GO:0005057 signal transducer activity, downstream of receptor ADRB1, EGFR, ERBB2, INSR, KDR, KIT, SMAD3 4.60495
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC 4.47254
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC 4.28299
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 4.25858
[MF] GO:0043168 anion binding ABCB1, ALOX15, APP, CSNK2A1, EGFR, ERBB2, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PTAFR, PTPRS, SLC1A1, SRC, TEK, TUBB3, XDH 4.10632
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 4.01679
[MF] GO:0019902 phosphatase binding BCL2, EGFR, ERBB2, HMGCR, MET, PPARA, SMAD3 3.84721
[MF] GO:0004672 protein kinase activity CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, SRC, TEK 3.8172
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.55739
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HMGCR, HSD17B1, SRC, XDH 3.39845
[MF] GO:0016491 oxidoreductase activity AKR1B1, ALOX15, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HMGCR, HSD17B1, XDH 3.387
[MF] GO:0019838 growth factor binding EGFR, ERBB2, IGF1R, INSR, KDR, TEK 3.33637
[MF] GO:0036094 small molecule binding ABCB1, ADORA1, CSNK2A1, EGFR, ERBB2, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, SLC1A1, SRC, TEK, TUBB3, XDH 3.31478
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6 3.31478
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, SRC, TEK 3.13035
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR 3.0886
[MF] GO:0008389 None CYP2A13, CYP2A6 3.00537
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 2.97677
[MF] GO:0019899 enzyme binding ADRB1, APP, BCL2, CYP1A1, CYP1A2, CYP2A6, DUSP3, EGFR, ERBB2, GRM5, HMGCR, HSPA1A, KIT, MET, PPARA, PTAFR, SMAD3, SRC, TEK, TNKS2 2.96334
[MF] GO:0016301 kinase activity CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, SRC, TEK 2.79228
[MF] GO:0030594 None GRIA2, GRIA4, GRIK5, GRM1, GRM5 2.63732
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.61502
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.61502
[MF] GO:0099583 None GRM1, GRM5 2.61462
[MF] GO:0097367 carbohydrate derivative binding ABCB1, ADORA1, APP, CSNK2A1, EGFR, ERBB2, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PTAFR, PTPRS, SRC, TEK, TUBB3 2.54036
[MF] GO:0019903 protein phosphatase binding BCL2, EGFR, ERBB2, HMGCR, MET 2.52374
[MF] GO:0032403 protein complex binding ACHE, ADORA1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, PPARA, SMAD3, SRC 2.48499
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, MMP12, PPARA, RORC, SMAD3, TNKS 2.40974
[MF] GO:0004971 None GRIA2, GRIA4 2.383
[MF] GO:0051425 None APP, INSR 2.383
[MF] GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity EGFR, ERBB2, KIT, MET 2.38145
[MF] GO:0035586 None ADORA1, ADORA3, PTAFR 2.33862
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, PPARA, SMAD3, SRC 2.33862
[MF] GO:0052813 phosphatidylinositol bisphosphate kinase activity EGFR, ERBB2, KIT, MET 2.32537
[MF] GO:0043169 cation binding ACHE, ALOX15, ALPL, APP, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, KIT, MMP12, NUAK1, PPARA, RORC, SLC1A1, SMAD3, TNKS, TNKS2, XDH 2.30363
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, CBR1, HMGCR, HSD17B1, XDH 2.30363
[MF] GO:0000166 nucleotide binding ABCB1, CSNK2A1, EGFR, ERBB2, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, SRC, TEK, TUBB3, XDH 2.26727
[MF] GO:1901265 nucleoside phosphate binding ABCB1, CSNK2A1, EGFR, ERBB2, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, SRC, TEK, TUBB3, XDH 2.26649
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, SRC, TEK 2.26425
[MF] GO:0035004 phosphatidylinositol 3-kinase activity EGFR, ERBB2, KIT, MET 2.23304
[MF] GO:0043559 insulin binding IGF1R, INSR 2.2189
[MF] GO:0046872 metal ion binding ALOX15, ALPL, APP, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, KIT, MMP12, NUAK1, PPARA, RORC, SLC1A1, SMAD3, TNKS, TNKS2, XDH 2.11391
[MF] GO:0004064 arylesterase activity CA1, CA2 2.08353
[MF] GO:0005088 Ras guanyl-nucleotide exchange factor activity ADRB1, EGFR, ERBB2, KIT, MET, TEK 2.07612
[MF] GO:0042802 identical protein binding ACHE, APP, BCL2, CSNK2A1, EGFR, ERBB2, FLT3, GRIK5, HMGCR, IGF1R, KDR, KIT, MET, SMAD3, XDH 2.02001


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.1791
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GRM3, GRIA2, GRM5, GPR35, ADORA3, GRIK5, PTAFR, GRM8, ADORA1, ADRB1, GRM1, GRIA4 8.472
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, CACNA1C, GRM1, GRIA4 8.472
Adherens junction_Homo sapiens_hsa04520 SMAD3, CSNK2A1, SRC, INSR, ERBB2, MET, EGFR, IGF1R 8.472
Ovarian steroidogenesis_Homo sapiens_hsa04913 INSR, HSD17B1, CYP1A1, CYP1B1, CYP19A1, IGF1R 6.4568
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KIT, KDR, ADRB1, MET, EGFR, IGF1R, HSPA1A 5.5815
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 5.5815
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KIT, KDR, TEK, MET, EGFR, IGF1R 5.3407
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, INSR, KIT, GRM8, GRM1, EGFR 5.3407
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 5.3518
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, TUBB3, ADRB1, GRM1, EGFR 5.3407
Calcium signaling pathway_Homo sapiens_hsa04020 GRM5, PTAFR, ERBB2, ADRB1, CACNA1C, GRM1, EGFR 4.7846
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, ERBB2, BCL2, TEK, EGFR, IGF1R 4.9739
Focal adhesion_Homo sapiens_hsa04510 SRC, ERBB2, KDR, BCL2, MET, EGFR, IGF1R 4.5063
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KIT, KDR, TEK, MET, EGFR, IGF1R 4.1979
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 INSR, KIT, KDR, BCL2, TEK, MET, EGFR, IGF1R 4.023
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, KIT, ERBB2, MET, EGFR 4.6592
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP19A1 4.9154
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, KIT, ERBB2, BCL2, MET, EGFR, IGF1R 3.613
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, CACNA1C, GRM1, GRIA4 3.8778
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, ERBB2, KDR, MET, EGFR, IGF1R 3.5464
cAMP signaling pathway_Homo sapiens_hsa04024 GRIA2, ADORA1, ADRB1, CACNA1C, PPARA, GRIA4 3.5761
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1, ADRB1 3.6552
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, GRM1, EGFR, IGF1R 3.4169
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1, ADRB1, CACNA1C 2.9838
Prostate cancer_Homo sapiens_hsa05215 ERBB2, BCL2, EGFR, IGF1R 2.9838
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, CACNA1C, GRM1 3.4483
Metabolic pathways_Homo sapiens_hsa01100 CBR1, CYP2A6, FUT7, HSD17B1, ALOX15, CYP1A2, CYP1A1, ALPL, AKR1B1, HMGCR, CYP19A1, XDH 2.6855
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, GRM1, EGFR, HSPA1A 2.8404
MicroRNAs in cancer_Homo sapiens_hsa05206 ABCB1, ERBB2, BCL2, CYP1B1, MET, EGFR 2.769
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET, EGFR 2.2699
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.3179
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.3746
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, ERBB2, EGFR 2.3026
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, CACNA1C, GRIA4 2.2949
Renin secretion_Homo sapiens_hsa04924 ADORA1, ADRB1, CACNA1C 2.3179
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1 2.3102
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2, CACNA1C 1.7799
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, CACNA1C, EGFR 1.9952
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.2699
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.2873
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, ERBB2, EGFR 2.0411
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, CACNA1C, GRIA4 1.9516
Bladder cancer_Homo sapiens_hsa05219 SRC, ERBB2, EGFR 2.8225
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, CACNA1C, EGFR, HSPA1A 1.6128
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.8404
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX15, CACNA1C 1.7775
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2, HMGCR 2.2699
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, PPARA 2.2797
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.7031
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, HMGCR, IGF1R 1.6799
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, CACNA1C, GRIA4 1.6411
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, BCL2 1.5328
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2, ADRB1, CACNA1C 1.5312
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, CACNA1C, EGFR 1.4755
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2, HSPA1A 1.2579
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MET, IGF1R 1.3702
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, BCL2 1.1033
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.9045
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.9115
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, IGF1R 0.8867
Insulin resistance_Homo sapiens_hsa04931 INSR, PPARA 1.0541
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8931
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.8867
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.8595
HTLV-I infection_Homo sapiens_hsa05166 SMAD3 0.2524
Toxoplasmosis_Homo sapiens_hsa05145 BCL2, HSPA1A 0.9978
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.8033
Taste transduction_Homo sapiens_hsa04742 CACNA1C, GRM1 1.2261
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 1.1546
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.6647
Alzheimer's disease_Homo sapiens_hsa05010 APP, CACNA1C 0.8033
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3179
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 1.1906
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.334
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.342
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.7783
Dilated cardiomyopathy_Homo sapiens_hsa05414 ADRB1, CACNA1C 1.1782
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3553
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.1577
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 1.1906
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.3553
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3413
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3912
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2 0.3853
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2645
Phagosome_Homo sapiens_hsa04145 TUBB3 0.3912
Apoptosis_Homo sapiens_hsa04210 BCL2 0.4181
Insulin signaling pathway_Homo sapiens_hsa04910 INSR 0.4181
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.4275
Platelet activation_Homo sapiens_hsa04611 SRC 0.4489
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.4516
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.4216
Cell cycle_Homo sapiens_hsa04110 SMAD3 0.4489
Axon guidance_Homo sapiens_hsa04360 MET 0.4433
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4489
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.4516
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.3947
Vascular smooth muscle contraction_Homo sapiens_hsa04270 CACNA1C 0.4516
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 IGF1R 0.5038
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.4943
Melanogenesis_Homo sapiens_hsa04916 KIT 0.502
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.502
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5038
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.502
Non-small cell lung cancer_Homo sapiens_hsa05223 ERBB2, EGFR 1.4755
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5056
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.505
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5184
Rheumatoid arthritis_Homo sapiens_hsa05323 TEK 0.5193
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, KIT 1.4711
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.5251
Salivary secretion_Homo sapiens_hsa04970 ADRB1 0.5193
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, BCL2 1.421
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2 1.358
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5193
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.524
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.5283
Endometrial cancer_Homo sapiens_hsa05213 ERBB2, EGFR 1.527
Small cell lung cancer_Homo sapiens_hsa05222 BCL2 0.523
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.5522
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.5193
Peroxisome_Homo sapiens_hsa04146 XDH 0.5261
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.3947
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.5522
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.5261
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.5393
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5522
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5405
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5589
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX15 1.421
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.5522
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR, CACNA1C 1.5578
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5781
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2 1.5479
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2, BCL2 1.5312
Shigellosis_Homo sapiens_hsa05131 SRC 0.5802
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.5859
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B1 0.6144
Staphylococcus aureus infection_Homo sapiens_hsa05150 PTAFR 0.6313
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6345
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3 0.6345
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.6799
Malaria_Homo sapiens_hsa05144 MET 0.6688
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.3407
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.7082
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.753
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.9115
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7849
Galactose metabolism_Homo sapiens_hsa00052 AKR1B1 0.8265
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8595
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8176
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0748
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B1 0.8088
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B1 0.7783
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8633
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8265
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8595
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.9087
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0793


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)