Prescription ID | TCMF5974 |
Pinyin Name | Yang Xin Ning Shen Wan |
Chinese Name | 养心宁神丸 |
English Name | Yang Xin Ning Shen Pills |
Function Description | 心悸, 不寐, 耳鸣, 眩晕 |
Indications | Tinnitus disorder, Vertigo disorder, Insomnia disorder, Insomnia, Tinnitus, Palpitations, Dizziness |
Disease ICD-11 Category |
SC75 [Tinnitus disorder (TM1), 耳鸣 (TM1)
]; SD22 [Vertigo disorder (TM1), 眩晕 (TM1) ]; SD84 [Insomnia disorder (TM1), 不寐 (TM1) ]; 7A0Z [Insomnia disorders, unspecified, 失眠障碍,未特指的 ]; MC41 [Tinnitus, 耳鸣 ]; MC81.2 [Palpitations, 心悸 ]; MB48 [Dizziness and giddiness, 头晕和眩晕 ]; |
Human Tissues Associated with Indication | Heart, Brain |
Reference | CFDA |
Reference Book/link | http://samr.cfda.gov.cn/WS01/CL0001/ |
Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
---|---|---|---|---|
TCMH426 | Codonopsis pilosula | 党参 | TCMH426 | ITSAL4530-14 |
TCMH2052 | Ziziphus jujuba var. spinosa | 酸枣仁 | TCMH2052 | ITSAM943-14 |
TCMH606 | Wolfiporia cocos | 茯苓 | TCMH606 | GBPOL314-13 |
TCMH2554 | Polygala tenuifolia | 远志 | TCMH2554 | MF096619 |
TCMH120 | Atractylodes macrocephala | 白术 | TCMH120 | ITSAN4430-14 |
TCMH1275 | Nelumbo nucifera | 莲子 | TCMH1275 | ITSAI3109-14 |
TCMH1845 | Dioscorea batatas | 山药 | TCMH1845 | |
TCMH407 | Salvia miltiorrhiza | 丹参 | TCMH407 | ITSAH2408-14 |
TCMH388 | Ziziphus jujuba | 大枣 | TCMH388 | ITSAM869-14 |
TCMH1329 | Arillus longan | 龙眼肉 | TCMH1329 | |
TCMH1920 | Acorus tatarinowii | 石菖蒲 | TCMH1920 | ITSAI4409-14 |
TCMH243 | Pericarpium citri reticulatae | 陈皮 | TCMH243 |
Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
---|---|---|---|---|
TCMT100 | TTR | Transthyretin | Unclassified | P02766 |
TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
TCMT102 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | Hydrolase | P24666 |
TCMT103 | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | Hydrolase | P10586 |
TCMT107 | GRIK2 | Glutamate receptor ionotropic kainate 2 | Ion channel | Q13002 |
TCMT109 | GRIA2 | Glutamate receptor ionotropic, AMPA 2 | Ion channel | P42262 |
TCMT110 | GRIA4 | Glutamate receptor ionotropic, AMPA 4 | Ion channel | P48058 |
TCMT111 | GRIK5 | Glutamate receptor ionotropic kainate 5 | Ion channel | Q16478 |
TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
TCMT126 | TERT | Telomerase reverse transcriptase | Transferase | O14746 |
TCMT127 | PARP1 | Poly [ADP-ribose] polymerase-1 | Transferase | P09874 |
TCMT13 | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | Lyase | P27695 |
TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
TCMT131 | ACHE | Acetylcholinesterase | Hydrolase | P22303 |
TCMT133 | CA1 | Carbonic anhydrase I | Lyase | P00915 |
TCMT134 | CA2 | Carbonic anhydrase II | Lyase | P00918 |
TCMT135 | CA14 | Carbonic anhydrase XIV | Lyase | Q9ULX7 |
TCMT136 | CA12 | Carbonic anhydrase XII | Lyase | O43570 |
TCMT137 | CA9 | Carbonic anhydrase IX | Lyase | Q16790 |
TCMT138 | CA7 | Carbonic anhydrase VII | Lyase | P43166 |
TCMT142 | CA4 | Carbonic anhydrase IV | Lyase | P22748 |
TCMT150 | RORC | Nuclear receptor ROR-gamma | Nuclear receptor | P51449 |
TCMT156 | CYP19A1 | Cytochrome P450 19A1 | Oxidoreductase | P11511 |
TCMT159 | TYR | Tyrosinase | Oxidoreductase | P14679 |
TCMT161 | HCAR2 | Hydroxycarboxylic acid receptor 2 | GPCR | Q8TDS4 |
TCMT171 | PTPN6 | Protein-tyrosine phosphatase 1C | Hydrolase | P29350 |
TCMT174 | HSD11B1 | 11-beta-hydroxysteroid dehydrogenase 1 | Oxidoreductase | P28845 |
TCMT189 | DUSP3 | Dual specificity protein phosphatase 3 | Hydrolase | P51452 |
TCMT190 | PTPN2 | T-cell protein-tyrosine phosphatase | Hydrolase | P17706 |
TCMT2 | MAPT | Microtubule-associated protein tau | Unclassified | P10636 |
TCMT210 | CES2 | Carboxylesterase 2 | Hydrolase | O00748 |
TCMT211 | CES1 | Acyl coenzyme A:cholesterol acyltransferase | Transferase | P23141 |
TCMT212 | SRC | Tyrosine-protein kinase SRC | Kinase | P12931 |
TCMT215 | CYP1A1 | Cytochrome P450 1A1 | Oxidoreductase | P04798 |
TCMT217 | CYP2C8 | Cytochrome P450 2C8 | Oxidoreductase | P10632 |
TCMT219 | CYP1A2 | Cytochrome P450 1A2 | Oxidoreductase | P05177 |
TCMT22 | ALPI | Intestinal alkaline phosphatase | Hydrolase | P09923 |
TCMT223 | AKR1B1 | Aldose reductase | Oxidoreductase | P15121 |
TCMT23 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | Hydrolase | P05186 |
TCMT233 | PTPN11 | Protein-tyrosine phosphatase 2C | Hydrolase | Q06124 |
TCMT236 | ESR2 | Estrogen receptor beta | Nuclear receptor | Q92731 |
TCMT239 | PIM1 | Serine/threonine-protein kinase PIM1 | Kinase | P11309 |
TCMT247 | ADRA2A | Alpha-2a adrenergic receptor | GPCR | P08913 |
TCMT257 | CYP1B1 | Cytochrome P450 1B1 | Oxidoreductase | Q16678 |
TCMT260 | FLT3 | Tyrosine-protein kinase receptor FLT3 | Kinase | P36888 |
TCMT261 | DAPK1 | Death-associated protein kinase 1 | Kinase | P53355 |
TCMT27 | DRD1 | Dopamine D1 receptor | GPCR | P21728 |
TCMT280 | AKR1B10 | Aldo-keto reductase family 1 member B10 | Oxidoreductase | O60218 |
TCMT295 | MMP1 | Matrix metalloproteinase-1 | Hydrolase | P03956 |
TCMT296 | ADORA1 | Adenosine A1 receptor | GPCR | P30542 |
TCMT297 | FABP4 | Fatty acid binding protein adipocyte | Unclassified | P15090 |
TCMT298 | FABP3 | Fatty acid binding protein muscle | Hydrolase | P05413 |
TCMT302 | HMGCR | HMG-CoA reductase | Oxidoreductase | P04035 |
TCMT306 | MMP2 | Matrix metalloproteinase-2 | Hydrolase | P08253 |
TCMT307 | KCNH2 | HERG | Ion channel | Q12809 |
TCMT31 | CYP2C19 | Cytochrome P450 2C19 | Oxidoreductase | P33261 |
TCMT321 | MMP9 | Matrix metalloproteinase 9 | Hydrolase | P14780 |
TCMT322 | MMP13 | Matrix metalloproteinase 13 | Hydrolase | P45452 |
TCMT34 | CYP2D6 | Cytochrome P450 2D6 | Oxidoreductase | P10635 |
TCMT344 | AOX1 | Aldehyde oxidase | Oxidoreductase | Q06278 |
TCMT354 | AURKA | Serine/threonine-protein kinase Aurora-A | Kinase | O14965 |
TCMT359 | FYN | Tyrosine-protein kinase FYN | Kinase | P06241 |
TCMT36 | HTR1A | Serotonin 1a (5-HT1a) receptor | GPCR | P08908 |
TCMT369 | IGF1R | Insulin-like growth factor I receptor | Kinase | P08069 |
TCMT370 | KDR | Vascular endothelial growth factor receptor 2 | Kinase | P35968 |
TCMT374 | AURKB | Serine/threonine-protein kinase Aurora-B | Kinase | Q96GD4 |
TCMT377 | INSR | Insulin receptor | Kinase | P06213 |
TCMT38 | DRD2 | Dopamine D2 receptor | GPCR | P14416 |
TCMT388 | AXL | Tyrosine-protein kinase receptor UFO | Kinase | P30530 |
TCMT401 | MET | Hepatocyte growth factor receptor | Kinase | P08581 |
TCMT418 | EPHB4 | Ephrin type-B receptor 4 | Kinase | P54760 |
TCMT422 | CAMK2B | CaM kinase II beta | Kinase | Q13554 |
TCMT423 | EGFR | Epidermal growth factor receptor erbB1 | Kinase | P00533 |
TCMT436 | NUAK1 | NUAK family SNF1-like kinase 1 | Kinase | O60285 |
TCMT44 | GLO1 | Glyoxalase I | Lyase | Q04760 |
TCMT445 | NEK2 | Serine/threonine-protein kinase NEK2 | Kinase | P51955 |
TCMT457 | FLT4 | Vascular endothelial growth factor receptor 3 | Kinase | P35916 |
TCMT46 | F3 | Coagulation factor III | Unclassified | P13726 |
TCMT462 | NEK6 | Serine/threonine-protein kinase NEK6 | Kinase | Q9HC98 |
TCMT47 | BCL2 | Apoptosis regulator Bcl-2 | Ion channel | P10415 |
TCMT479 | AKT1 | Serine/threonine-protein kinase AKT | Kinase | P31749 |
TCMT484 | PLK1 | Serine/threonine-protein kinase PLK1 | Kinase | P53350 |
TCMT502 | TEK | Tyrosine-protein kinase TIE-2 | Kinase | Q02763 |
TCMT536 | PDGFRB | Platelet-derived growth factor receptor beta | Kinase | P09619 |
TCMT558 | TOP2A | DNA topoisomerase II alpha | Isomerase | P11388 |
TCMT563 | CDC25B | Dual specificity phosphatase Cdc25B | Hydrolase | P30305 |
TCMT565 | EP300 | Histone acetyltransferase p300 | Transferase | Q09472 |
TCMT591 | ESRRA | Estrogen-related receptor alpha | Nuclear receptor | P11474 |
TCMT592 | XDH | Xanthine dehydrogenase | Oxidoreductase | P47989 |
TCMT594 | PTAFR | Platelet activating factor receptor | GPCR | P25105 |
TCMT597 | SLC28A3 | Solute carrier family 28 member 3 | Transporter | Q9HAS3 |
TCMT599 | UBE2N | Ubiquitin-conjugating enzyme E2 N | Transferase | P61088 |
TCMT614 | EGLN1 | Egl nine homolog 1 | Oxidoreductase | Q9GZT9 |
TCMT626 | BRAF | Serine/threonine-protein kinase B-raf | Kinase | P15056 |
TCMT63 | PPARA | Peroxisome proliferator-activated receptor alpha | Nuclear receptor | Q07869 |
TCMT632 | PNP | Purine nucleoside phosphorylase | Transferase | P00491 |
TCMT633 | SLC6A4 | Serotonin transporter | Transporter | P31645 |
TCMT634 | SLC6A2 | Norepinephrine transporter | Transporter | P23975 |
TCMT649 | DRD5 | Dopamine D5 receptor | GPCR | P21918 |
TCMT651 | DRD3 | Dopamine D3 receptor | GPCR | P35462 |
TCMT653 | GRM1 | Metabotropic glutamate receptor 1 | GPCR | Q13255 |
TCMT654 | GRM5 | Metabotropic glutamate receptor 5 | GPCR | P41594 |
TCMT655 | GRM2 | Metabotropic glutamate receptor 2 | GPCR | Q14416 |
TCMT656 | GRM3 | Metabotropic glutamate receptor 3 | GPCR | Q14832 |
TCMT657 | GRM4 | Metabotropic glutamate receptor 4 | GPCR | Q14833 |
TCMT66 | HSD17B2 | Estradiol 17-beta-dehydrogenase 2 | Oxidoreductase | P37059 |
TCMT660 | GRM8 | Metabotropic glutamate receptor 8 | GPCR | O00222 |
TCMT664 | SLC1A1 | Excitatory amino acid transporter 3 | Transporter | P43005 |
TCMT680 | KAT2B | Histone acetyltransferase PCAF | Transferase | Q92831 |
TCMT690 | HDAC3 | Histone deacetylase 3 | Hydrolase | O15379 |
TCMT709 | SLC28A2 | Sodium/nucleoside cotransporter 2 | Transporter | O43868 |
TCMT710 | SLC28A1 | Sodium/nucleoside cotransporter 1 | Transporter | O00337 |
TCMT721 | HSPA1A | Heat shock 70 kDa protein 1 | Unclassified | P0DMV8 |
TCMT734 | MMP12 | Matrix metalloproteinase 12 | Hydrolase | P39900 |
TCMT737 | APOBEC3G | DNA dC->dU-editing enzyme APOBEC-3G | Unclassified | Q9HC16 |
TCMT739 | GPR35 | G-protein coupled receptor 35 | GPCR | Q9HC97 |
TCMT740 | PIK3CG | PI3-kinase p110-gamma subunit | Transferase | P48736 |
TCMT752 | CSNK2A1 | Casein kinase II alpha | Kinase | P68400 |
TCMT753 | SMAD3 | Mothers against decapentaplegic homolog 3 | Unclassified | P84022 |
TCMT755 | PLK4 | Serine/threonine-protein kinase PLK4 | Kinase | O00444 |
TCMT756 | MAP3K8 | Mitogen-activated protein kinase kinase kinase 8 | Kinase | P41279 |
TCMT759 | SAE1 | SUMO-activating enzyme subunit 1 | Unclassified | Q9UBE0 |
TCMT784 | AVPR2 | Vasopressin V2 receptor | GPCR | P30518 |
TCMT785 | CXCR1 | Interleukin-8 receptor A | GPCR | P25024 |
TCMT786 | CCR4 | C-C chemokine receptor type 4 | GPCR | P51679 |
TCMT791 | PKN1 | Protein kinase N1 | Kinase | Q16512 |
TCMT793 | PYGL | Liver glycogen phosphorylase | Transferase | P06737 |
TCMT8 | KDM4E | Lysine-specific demethylase 4D-like | Oxidoreductase | B2RXH2 |
TCMT808 | FABP5 | Fatty acid binding protein epidermal | Unclassified | Q01469 |
TCMT809 | FABP2 | Fatty acid binding protein intestinal | Unclassified | P12104 |
TCMT810 | TLR2 | Toll-like receptor 2 | Unclassified | O60603 |
TCMT82 | ESR1 | Estrogen receptor alpha | Nuclear receptor | P03372 |
TCMT822 | FUT7 | Alpha-(1,3)-fucosyltransferase 7 | Transferase | Q11130 |
TCMT83 | CD38 | Lymphocyte differentiation antigen CD38 | Unclassified | P28907 |
TCMT910 | ESRRB | Estrogen-related receptor beta | Nuclear receptor | O95718 |
TCMT953 | PNMT | Phenylethanolamine N-methyltransferase | Transferase | P11086 |
Target ID | Target Name |
---|---|
TCMT1168 | Trichomonas vaginalis |
TCMT1175 | Human immunodeficiency virus |
TCMT1176 | Streptococcus pneumoniae |
TCMT1178 | Actinomyces viscosus |
TCMT1179 | Escherichia coli ATCC 8739 |
TCMT1180 | Human herpesvirus 2 |
TCMT1181 | Mycobacterium tuberculosis H37Ra |
TCMT1189 | Pseudomonas fluorescens |
TCMT1190 | Plasmodium falciparum (isolate FcB1 / Columbia) |
TCMT1208 | Escherichia coli K12 |
TCMT1209 | Staphylococcus haemolyticus |
TCMT1210 | Streptococcus sobrinus |
TCMT1211 | Fusobacterium nucleatum |
TCMT1212 | Verticillium dahliae |
TCMT1213 | Neisseria gonorrhoeae |
TCMT1214 | Enterococcus faecium |
TCMT1215 | Pseudomonas aeruginosa PAO1 |
TCMT1218 | Staphylococcus aureus |
TCMT1221 | Human herpesvirus 4 |
TCMT1222 | Plasmodium falciparum D6 |
TCMT1223 | Staphylococcus epidermidis |
TCMT1226 | Klebsiella pneumoniae |
TCMT1229 | Enterococcus faecalis |
TCMT1231 | Human herpesvirus 1 strain KOS |
TCMT1232 | Pseudomonas aeruginosa |
TCMT1243 | Aspergillus flavus |
TCMT1245 | Phytophthora cactorum |
TCMT1246 | Escherichia coli |
TCMT1247 | Human herpesvirus 1 |
TCMT1248 | Hepatitis C virus |
TCMT1251 | Candida albicans |
TCMT1253 | Penicillium chrysogenum |
TCMT1255 | Human immunodeficiency virus 1 |
TCMT1282 | Colletotrichum orbiculare |
TCMT1284 | Penicillium expansum |
TCMT1286 | Bacillus cereus |
TCMT1293 | Vaccinia virus |
TCMT1294 | Human parainfluenza virus 3 |
TCMT1310 | Enterococcus hirae |
TCMT1318 | Human T-lymphotropic virus 1 |
TCMT1321 | Staphylococcus hominis |
TCMT1343 | Staphylococcus simulans |
TCMT1344 | Staphylococcus sciuri |
TCMT1346 | Helicobacter pylori |
TCMT1349 | Helicobacter pylori SS1 |
TCMT1353 | Plasmodium yoelii |
TCMT1355 | Rhodococcus equi |
TCMT1361 | Neisseria meningitidis |
TCMT1370 | Prevotella melaninogenica |
TCMT1382 | Plasmodium falciparum (isolate K1 / Thailand) |
TCMT1393 | Vibrio sp. |
TCMT1405 | Penicillium citrinum |
TCMT1408 | Colletotrichum gloeosporioides |
TCMT1412 | Salmonella typhimurium |
TCMT1438 | Plasmodium falciparum |
TCMT1439 | Mycobacterium smegmatis |
TCMT1442 | Leishmania donovani |
TCMT1443 | Leishmania amazonensis |
TCMT1447 | Respiratory syncytial virus |
TCMT1448 | Enterobacter aerogenes |
TCMT1449 | Influenza A virus |
TCMT1450 | Plasmodium falciparum 3D7 |
TCMT1454 | Bacillus subtilis |
TCMT1455 | Mycobacterium tuberculosis H37Rv |
TCMT1458 | Filobasidiella neoformans |
TCMT1462 | Streptococcus mutans |
TCMT1463 | Mycobacterium tuberculosis |
TCMT1464 | Hepatitis B virus |
TCMT1465 | Entamoeba histolytica |
GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
---|---|---|---|
[BP] GO:0042221 | response to chemical | ADRA2A, AKR1B1, ALPL, APEX1, AXL, BCL2, CA2, CA9, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MMP2, MMP9, PPARA, PTAFR, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TYR | 13.0637 |
[BP] GO:0065008 | regulation of biological quality | ACHE, ADORA1, ADRA2A, AKR1B1, APEX1, AURKB, AXL, BCL2, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, F3, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSD11B1, HSD17B2, HSPA1A, HTR1A, INSR, KCNH2, KDR, MET, PPARA, PTAFR, SLC1A1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, XDH | 13.0637 |
[BP] GO:1901700 | response to oxygen-containing compound | AKR1B1, ALPL, APEX1, AXL, BCL2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESRRA, FABP3, GRIK5, GRM5, HMGCR, HSD17B2, IGF1R, INSR, MMP2, MMP9, PPARA, PTAFR, RORC, SLC6A4, SRC, TEK, TYR | 13.0637 |
[BP] GO:0010033 | response to organic substance | ADRA2A, AKR1B1, ALPL, APEX1, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, PPARA, PTAFR, RORC, SLC6A4, SMAD3, SRC, TEK, TYR | 12.4649 |
[BP] GO:0042127 | regulation of cell proliferation | ADORA1, ADORA3, ADRA2A, AKR1B1, BCL2, CDC25B, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, F3, FABP3, FLT3, HMGCR, HSPA1A, HTR1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PIM1, PTAFR, SLC6A4, SMAD3, SRC, TEK, TERT, XDH | 11.1691 |
[BP] GO:0048522 | positive regulation of cellular process | ACHE, ADORA1, ADRA2A, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GPR35, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSPA1A, HTR1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTAFR, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, XDH | 11.14 |
[BP] GO:0010646 | regulation of cell communication | ACHE, ADORA1, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, HTR1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PTPN1, SLC6A4, SMAD3, SRC, TEK, TERT, XDH | 10.188 |
[BP] GO:0048518 | positive regulation of biological process | ACHE, ADORA1, ADRA2A, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSPA1A, HTR1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTAFR, PTPN1, RORC, SLC1A1, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, XDH | 10.188 |
[BP] GO:0023051 | regulation of signaling | ACHE, ADORA1, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, HTR1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PTPN1, SLC6A4, SMAD3, SRC, TEK, TERT, XDH | 10.0728 |
[BP] GO:0014070 | response to organic cyclic compound | ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESRRA, FLT3, PTAFR, RORC, SLC6A4, SRC, TEK, TYR | 10.0728 |
[BP] GO:0009719 | response to endogenous stimulus | ADRA2A, AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DRD1, DRD5, EGFR, ESR1, ESRRA, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, PPARA, PTAFR, SLC6A4, SMAD3, SRC, TEK | 10.0429 |
[BP] GO:0032501 | multicellular organismal process | ADORA1, ADRA2A, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESRRB, F3, FABP4, GRM1, GRM5, GRM8, HMGCR, HSD17B2, HTR1A, IGF1R, INSR, KCNH2, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTAFR, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TYR | 9.9465 |
[BP] GO:0010647 | positive regulation of cell communication | ADORA1, ADRA2A, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, GRM1, HCAR2, HMGCR, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, TERT, XDH | 9.66038 |
[BP] GO:0023056 | positive regulation of signaling | ADORA1, ADRA2A, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, GRM1, HCAR2, HMGCR, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, TERT, XDH | 9.63113 |
[BP] GO:0070887 | cellular response to chemical stimulus | ADRA2A, AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD5, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM5, HSPA1A, IGF1R, INSR, KCNH2, KDR, MMP2, MMP9, PTAFR, RORC, SLC6A4, SMAD3, SRC, TERT | 9.25124 |
[BP] GO:0032879 | regulation of localization | ACHE, ADORA1, ADORA3, ADRA2A, APEX1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F3, GPR35, GRIK5, GRM5, HCAR2, HMGCR, HSPA1A, HTR1A, IGF1R, INSR, KCNH2, KDR, MET, MMP12, MMP9, PPARA, PTAFR, PTPN1, SLC6A4, SMAD3, SRC, TEK, TERT | 9.06145 |
[BP] GO:0042592 | homeostatic process | ADORA1, ADRA2A, AKR1B1, APEX1, AXL, BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, INSR, KCNH2, MET, SMAD3, SRC, TERT | 8.63289 |
[BP] GO:0050896 | response to stimulus | ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESRRA, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HMGCR, HSD17B2, HSPA1A, HTR1A, IGF1R, INSR, KCNH2, KDR, MMP12, MMP2, MMP9, NUAK1, PPARA, PTAFR, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TYR | 8.60294 |
[BP] GO:0008284 | positive regulation of cell proliferation | ADRA2A, AKR1B1, BCL2, CDC25B, CSNK2A1, DRD2, DRD3, EGFR, ESR1, F3, FLT3, HMGCR, HTR1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, PIM1, PTAFR, TEK, TERT | 8.5266 |
[BP] GO:0050804 | modulation of chemical synaptic transmission | ACHE, ADORA1, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, SLC6A4 | 8.49414 |
[BP] GO:0099177 | regulation of trans-synaptic signaling | ACHE, ADORA1, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, SLC6A4 | 8.49414 |
[BP] GO:0019220 | regulation of phosphate metabolic process | ADORA1, ADRA2A, BCL2, CDC25B, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, PTAFR, PTPN1, SMAD3, SRC, TEK, XDH | 8.43487 |
[BP] GO:0051174 | regulation of phosphorus metabolic process | ADORA1, ADRA2A, BCL2, CDC25B, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, PTAFR, PTPN1, SMAD3, SRC, TEK, XDH | 8.36813 |
[BP] GO:0043067 | regulation of programmed cell death | ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, GRIK5, HCAR2, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, XDH | 8.36813 |
[BP] GO:0010941 | regulation of cell death | ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, GRIK5, HCAR2, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, XDH | 8.34868 |
[BP] GO:0006629 | lipid metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD2, EGFR, ESR1, FABP3, FABP4, FUT7, HMGCR, HSD11B1, HSD17B2, MET, PPARA | 8.32464 |
[BP] GO:0009725 | response to hormone | ADRA2A, AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, INSR, PPARA, PTAFR, SLC6A4, SRC, TEK | 8.32464 |
[BP] GO:0030334 | regulation of cell migration | ADORA1, ADORA3, ADRA2A, APEX1, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PTAFR, SMAD3, SRC, TEK, TERT | 7.99587 |
[BP] GO:0009636 | response to toxic substance | AKR1B1, ALPL, APEX1, AXL, BCL2, CES1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, HMGCR, KDR, SLC6A4, SRC | 7.89102 |
[BP] GO:0051716 | cellular response to stimulus | ADRA2A, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD5, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, HSPA1A, IGF1R, INSR, KCNH2, KDR, MMP2, MMP9, NUAK1, PTAFR, PTPN1, RORC, SLC6A4, SMAD3, SRC, TERT, TOP2A | 7.89102 |
[BP] GO:0042981 | regulation of apoptotic process | ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, GRIK5, HCAR2, HMGCR, HSPA1A, IGF1R, KDR, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, XDH | 7.7967 |
[BP] GO:0040012 | regulation of locomotion | ADORA1, ADORA3, ADRA2A, APEX1, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PTAFR, SMAD3, SRC, TEK, TERT | 7.77045 |
[BP] GO:0007193 | None | ADORA1, ADRA2A, DRD2, DRD3, GRM1, GRM3, GRM5, GRM8, HTR1A | 7.61627 |
[BP] GO:2000145 | regulation of cell motility | ADORA1, ADORA3, ADRA2A, APEX1, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PTAFR, SMAD3, SRC, TEK, TERT | 7.59003 |
[BP] GO:0042493 | response to drug | AKR1B1, APEX1, AXL, BCL2, CA9, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, FABP3, HMGCR, KCNH2, KDR, PTAFR, SLC6A2, SLC6A4, SRC | 7.59003 |
[BP] GO:0071310 | cellular response to organic substance | ADRA2A, AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, DRD1, DRD5, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, INSR, KDR, MMP2, PTAFR, RORC, SLC6A4, SMAD3, SRC | 7.58063 |
[BP] GO:0019748 | secondary metabolic process | AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR | 7.58063 |
[BP] GO:0008202 | steroid metabolic process | AKR1B1, AKR1B10, CES1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, ESR1, HMGCR, HSD11B1, HSD17B2 | 7.54671 |
[BP] GO:0003018 | None | ADORA1, ADRA2A, DRD1, DRD5, EGFR, HMGCR, HTR1A, PTAFR, SLC6A4, SRC, TEK | 7.42916 |
[BP] GO:0007188 | None | ADORA1, ADRA2A, DRD1, DRD2, DRD3, DRD5, GRM1, GRM3, GRM5, GRM8, HTR1A | 7.40708 |
[BP] GO:0001505 | regulation of neurotransmitter levels | ACHE, CYP1B1, DRD1, DRD2, DRD3, EGFR, GRIK5, HTR1A, INSR, SLC1A1, SLC6A2, SLC6A4, SMAD3 | 7.40679 |
[BP] GO:0048878 | chemical homeostasis | ADRA2A, AKR1B1, BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, FABP3, FABP4, GPR35, GRIK5, GRM1, GRM5, INSR, KCNH2, MET, SMAD3 | 7.40251 |
[BP] GO:0051049 | regulation of transport | ACHE, ADORA1, ADRA2A, AXL, BCL2, CA2, CA7, CYP19A1, DRD1, DRD2, DRD3, EGFR, GPR35, GRIK5, GRM5, HCAR2, HMGCR, HSPA1A, HTR1A, INSR, KCNH2, MMP12, MMP9, PPARA, PTAFR, PTPN1, SLC6A4, SMAD3, SRC, TERT | 7.23335 |
[BP] GO:0008152 | metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD11B1, HSD17B2, HSPA1A, HTR1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTAFR, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH | 7.20049 |
[BP] GO:0010648 | negative regulation of cell communication | ACHE, ADORA1, ADRA2A, BCL2, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, GPR35, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, PTPN1, SLC6A4, SMAD3, SRC, TERT, XDH | 7.17358 |
[BP] GO:0023057 | negative regulation of signaling | ACHE, ADORA1, ADRA2A, BCL2, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, GPR35, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, PTPN1, SLC6A4, SMAD3, SRC, TERT, XDH | 7.15235 |
[BP] GO:0009967 | positive regulation of signal transduction | ADORA1, ADRA2A, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, GRM1, HMGCR, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, TERT, XDH | 7.15162 |
[BP] GO:0051966 | regulation of synaptic transmission, glutamatergic | ADORA1, DRD1, DRD2, EGFR, GRM1, GRM3, GRM5, GRM8 | 7.15162 |
[BP] GO:0048523 | negative regulation of cellular process | ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPR35, GRM3, GRM8, HMGCR, HSPA1A, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, XDH | 7.12769 |
[BP] GO:0051270 | regulation of cellular component movement | ADORA1, ADORA3, ADRA2A, APEX1, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PTAFR, SMAD3, SRC, TEK, TERT | 7.06603 |
[BP] GO:0050790 | regulation of catalytic activity | ADORA1, ADORA3, ADRA2A, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GRM1, GRM3, GRM5, HMGCR, HSPA1A, IGF1R, INSR, MMP9, NUAK1, PTAFR, PTPN1, SMAD3, SRC, TEK, TERT, XDH | 7.02636 |
[BP] GO:0010562 | positive regulation of phosphorus metabolic process | ADORA1, ADRA2A, BCL2, CDC25B, DRD1, DRD2, DRD5, EGFR, ESRRB, FABP3, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, MMP9, PTAFR, PTPN1, SMAD3, SRC, TEK, XDH | 7.01325 |
[BP] GO:0045937 | positive regulation of phosphate metabolic process | ADORA1, ADRA2A, BCL2, CDC25B, DRD1, DRD2, DRD5, EGFR, ESRRB, FABP3, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, MMP9, PTAFR, PTPN1, SMAD3, SRC, TEK, XDH | 7.01325 |
[BP] GO:0033993 | response to lipid | ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD17B2, PTAFR, RORC, SLC6A4, SRC, TYR | 7.01325 |
[BP] GO:0009628 | response to abiotic stimulus | ADORA1, AKR1B1, AURKB, BCL2, CA2, CYP1A1, DRD1, DRD2, DRD3, EGFR, GRM1, HMGCR, HSPA1A, MMP2, PPARA, PTAFR, SLC6A4, SMAD3, SRC, TEK, TERT, TYR | 7.00508 |
[BP] GO:0065009 | regulation of molecular function | ADORA1, ADORA3, ADRA2A, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FABP4, FLT3, GPR35, GRM1, GRM3, GRM5, HMGCR, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PIM1, PPARA, PTAFR, PTPN1, SMAD3, SRC, TEK, TERT, XDH | 6.91913 |
[BP] GO:1902531 | regulation of intracellular signal transduction | ADORA1, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DUSP3, EGFR, ESR1, F3, FLT3, GPR35, GRM1, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PTPN1, SRC, TEK, XDH | 6.85102 |
[BP] GO:0007187 | None | ADORA1, ADRA2A, DRD1, DRD2, DRD3, DRD5, GRM1, GRM3, GRM5, GRM8, HTR1A | 6.80555 |
[BP] GO:0051173 | positive regulation of nitrogen compound metabolic process | ADORA1, ADRA2A, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PTAFR, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH | 6.79855 |
[BP] GO:0044281 | small molecule metabolic process | AKR1B1, AKR1B10, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FABP3, FUT7, GLO1, HMGCR, HSPA1A, PIM1, PPARA, PTAFR, TYR, XDH | 6.74798 |
[BP] GO:0010243 | response to organonitrogen compound | AKR1B1, APEX1, DRD1, DRD2, DRD3, DRD5, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, PPARA, PTAFR, SLC6A4, SRC, TEK, TYR | 6.67991 |
[BP] GO:0060548 | negative regulation of cell death | ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TERT | 6.66758 |
[BP] GO:0007215 | None | GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 | 6.62837 |
[BP] GO:0015701 | bicarbonate transport | CA1, CA12, CA14, CA2, CA4, CA7, CA9 | 6.62837 |
[BP] GO:0009893 | positive regulation of metabolic process | ADORA1, ADRA2A, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PTAFR, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, XDH | 6.62837 |
[BP] GO:0030335 | positive regulation of cell migration | ADRA2A, BCL2, DRD1, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PTAFR, SMAD3, SRC, TEK, TERT | 6.60806 |
[BP] GO:0043069 | negative regulation of programmed cell death | ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TERT | 6.57092 |
[BP] GO:1902533 | positive regulation of intracellular signal transduction | ADORA1, ADRA2A, AKR1B1, AXL, BCL2, CYP1B1, DRD2, EGFR, F3, FLT3, GPR35, GRM1, HMGCR, HSPA1A, INSR, KDR, MET, PTPN1, SRC, TEK, XDH | 6.50158 |
[BP] GO:0048519 | negative regulation of biological process | ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPR35, GRM3, GRM8, HCAR2, HMGCR, HSPA1A, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, XDH | 6.4458 |
[BP] GO:0048584 | positive regulation of response to stimulus | ADORA1, ADRA2A, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, ESRRA, F3, FABP4, FLT3, GPR35, GRM1, HMGCR, HSPA1A, INSR, KDR, MET, MMP12, MMP2, MMP9, PTAFR, PTPN1, SMAD3, SRC, TEK, TERT, XDH | 6.44099 |
[BP] GO:2000147 | positive regulation of cell motility | ADRA2A, BCL2, DRD1, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PTAFR, SMAD3, SRC, TEK, TERT | 6.43616 |
[BP] GO:0031325 | positive regulation of cellular metabolic process | ADORA1, ADRA2A, AURKB, BCL2, CDC25B, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PTAFR, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH | 6.42611 |
[BP] GO:0010035 | response to inorganic substance | AKR1B1, APEX1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP4, KDR, MMP9, SRC, TERT | 6.39396 |
[BP] GO:0003013 | None | ADORA1, ADRA2A, DRD1, DRD5, EGFR, HMGCR, HTR1A, PTAFR, SLC6A4, SRC, TEK | 6.39012 |
[BP] GO:0010604 | positive regulation of macromolecule metabolic process | ADORA1, ADRA2A, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PTAFR, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, XDH | 6.37526 |
[BP] GO:0051272 | positive regulation of cellular component movement | ADRA2A, BCL2, DRD1, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PTAFR, SMAD3, SRC, TEK, TERT | 6.29797 |
[BP] GO:0044237 | cellular metabolic process | ACHE, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD17B2, HSPA1A, HTR1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP2, NUAK1, PIM1, PPARA, PTAFR, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH | 6.23646 |
[BP] GO:1901698 | response to nitrogen compound | AKR1B1, APEX1, DRD1, DRD2, DRD3, DRD5, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, PPARA, PTAFR, SLC6A4, SRC, TEK, TYR | 6.22865 |
[BP] GO:0040017 | positive regulation of locomotion | ADRA2A, BCL2, DRD1, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PTAFR, SMAD3, SRC, TEK, TERT | 6.10242 |
[BP] GO:1901615 | organic hydroxy compound metabolic process | AKR1B1, AKR1B10, BCL2, CES1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, HMGCR, HTR1A, PTAFR, TYR | 6.08703 |
[BP] GO:0097746 | None | ADORA1, ADRA2A, DRD1, DRD5, EGFR, HMGCR, HTR1A, PTAFR, SLC6A4 | 6.06102 |
[BP] GO:0035296 | None | ADORA1, ADRA2A, DRD1, DRD5, EGFR, HMGCR, HTR1A, PTAFR, SLC6A4 | 6.06102 |
[BP] GO:0007165 | signal transduction | ADORA1, ADORA3, ADRA2A, AKR1B1, AXL, BCL2, CA1, CA2, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, IGF1R, INSR, KCNH2, KDR, MET, MMP2, MMP9, NUAK1, PIM1, PPARA, PTAFR, PTPN1, RORC, SMAD3, SRC, TEK | 6.04067 |
[BP] GO:1901701 | cellular response to oxygen-containing compound | AKR1B1, APEX1, AXL, CYP1B1, DRD1, DRD5, EGFR, ESR1, GRIK5, GRM5, IGF1R, INSR, MMP2, MMP9, PTAFR, RORC, SLC6A4, SRC | 6.02729 |
[BP] GO:0048511 | rhythmic process | AXL, BCL2, CSNK2A1, DRD2, DRD3, EGFR, ESR1, PPARA, RORC, SLC6A4, SRC, TOP2A | 6.02729 |
[BP] GO:0071407 | cellular response to organic cyclic compound | ALPL, APEX1, CYP1A1, CYP1B1, DRD1, DRD5, EGFR, ESR1, FLT3, PTAFR, RORC, SLC6A4, SRC | 6.00653 |
[BP] GO:0043066 | negative regulation of apoptotic process | ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HMGCR, HSPA1A, IGF1R, KDR, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TERT | 5.9824 |
[BP] GO:0044092 | negative regulation of molecular function | ADORA3, ADRA2A, AURKB, CSNK2A1, CYP1B1, CYP2D6, DRD2, DRD3, DRD5, DUSP3, ESR1, FABP4, GPR35, GRM3, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC | 5.97692 |
[BP] GO:0051050 | positive regulation of transport | ACHE, ADORA1, ADRA2A, AXL, BCL2, CA2, CYP19A1, DRD1, DRD2, DRD3, EGFR, HCAR2, INSR, KCNH2, MMP12, PTAFR, SLC6A4, SMAD3, SRC, TERT | 5.92059 |
[BP] GO:0044255 | cellular lipid metabolic process | ACHE, AKR1B10, ALOX5, ALPI, CES1, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD2, EGFR, FABP3, FABP4, FUT7, HMGCR, MET, PPARA | 5.91681 |
[BP] GO:0010817 | regulation of hormone levels | ACHE, ADORA1, ADRA2A, AKR1B1, CYP19A1, CYP1A1, CYP1B1, DRD2, EGFR, ESR1, HCAR2, HMGCR, HSD11B1, HSD17B2, HTR1A | 5.90814 |
[BP] GO:0050880 | None | ADORA1, ADRA2A, DRD1, DRD5, EGFR, HMGCR, HTR1A, PTAFR, SLC6A4 | 5.86442 |
[BP] GO:0048513 | animal organ development | ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, INSR, KDR, PPARA, SMAD3, SRC, TEK, TYR | 5.8615 |
[BP] GO:0035150 | None | ADORA1, ADRA2A, DRD1, DRD5, EGFR, HMGCR, HTR1A, PTAFR, SLC6A4 | 5.84298 |
[BP] GO:0006730 | one-carbon metabolic process | CA1, CA12, CA2, CA4, CA7, CA9 | 5.67997 |
[BP] GO:0032502 | developmental process | ACHE, ADORA1, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CES1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD11B1, HSD17B2, INSR, KDR, MET, MMP2, MMP9, PIM1, PPARA, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TYR | 5.677 |
[BP] GO:0006796 | phosphate-containing compound metabolic process | ACHE, ALPI, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, PTAFR, PTPN1, SRC, TEK, XDH | 5.65281 |
[BP] GO:0046777 | protein autophosphorylation | AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK | 5.52984 |
[BP] GO:0019222 | regulation of metabolic process | ACHE, ADORA1, ADORA3, ADRA2A, APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, HTR1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIM1, PPARA, PTAFR, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, XDH | 5.49929 |
[BP] GO:0048585 | negative regulation of response to stimulus | ADORA1, ADRA2A, BCL2, CYP19A1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK, TERT, XDH | 5.47906 |
[BP] GO:0051239 | regulation of multicellular organismal process | ADORA1, ADORA3, ADRA2A, AXL, BCL2, CA2, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, ESRRB, F3, GPR35, GRM1, HCAR2, HMGCR, HSPA1A, INSR, KCNH2, KDR, MET, MMP12, MMP9, PIM1, PTAFR, SLC1A1, SLC6A4, SMAD3, SRC, TEK, TERT, XDH | 5.4674 |
[BP] GO:0001666 | response to hypoxia | ADORA1, BCL2, CYP1A1, DRD2, MMP2, PPARA, SLC6A4, SMAD3, SRC, TEK, TERT | 5.45364 |
[BP] GO:0032844 | regulation of homeostatic process | ADORA1, ADRA2A, AURKB, BCL2, CA2, CA7, DRD1, DRD2, DRD3, EGFR, HCAR2, HMGCR, KDR, SRC | 5.42684 |
[BP] GO:0007166 | cell surface receptor signaling pathway | ADORA1, ADORA3, AXL, BCL2, CA1, CSNK2A1, DRD2, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTAFR, PTPN1, SMAD3, SRC, TEK | 5.37182 |
[BP] GO:0036293 | response to decreased oxygen levels | ADORA1, BCL2, CYP1A1, DRD2, MMP2, PPARA, SLC6A4, SMAD3, SRC, TEK, TERT | 5.3314 |
[BP] GO:0045776 | None | ADORA1, DRD2, DRD3, DRD5, PPARA, PTAFR | 5.30399 |
[BP] GO:0051896 | regulation of protein kinase B signaling | AXL, DRD2, DRD3, EGFR, F3, INSR, MET, SRC, TEK, XDH | 5.26076 |
[BP] GO:0006793 | phosphorus metabolic process | ACHE, ALPI, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, PTAFR, PTPN1, SRC, TEK, XDH | 5.26076 |
[BP] GO:0051240 | positive regulation of multicellular organismal process | ADRA2A, AXL, BCL2, CA2, CYP1B1, DRD2, DRD3, EGFR, ESRRB, F3, HCAR2, HMGCR, HSPA1A, KDR, MET, MMP12, MMP9, PIM1, PTAFR, SLC1A1, SMAD3, SRC, TEK, TERT | 5.25473 |
[BP] GO:0050801 | ion homeostasis | BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, FABP3, GPR35, GRM1, GRM5, KCNH2, SMAD3 | 5.23257 |
[BP] GO:0006805 | xenobiotic metabolic process | CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, RORC | 5.18957 |
[BP] GO:0007196 | None | GRM1, GRM3, GRM5, GRM8 | 5.15454 |
[BP] GO:0048661 | positive regulation of smooth muscle cell proliferation | AKR1B1, EGFR, HMGCR, MMP2, MMP9, PTAFR, TERT | 5.1523 |
[BP] GO:0071495 | cellular response to endogenous stimulus | ADRA2A, AKR1B1, APEX1, DRD1, DRD5, EGFR, ESR1, FLT3, GRM5, IGF1R, INSR, MMP2, PTAFR, SLC6A4, SMAD3, SRC | 5.13002 |
[BP] GO:0018958 | None | AKR1B1, BCL2, DRD1, DRD2, DRD3, HTR1A, TYR | 5.08627 |
[BP] GO:0080134 | regulation of response to stress | ADORA1, ADRA2A, CYP19A1, DRD2, DUSP3, EGFR, ESR1, F3, FABP4, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP2, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TERT, XDH | 5.01354 |
[BP] GO:0070482 | response to oxygen levels | ADORA1, BCL2, CYP1A1, DRD2, MMP2, PPARA, SLC6A4, SMAD3, SRC, TEK, TERT | 5.00885 |
[BP] GO:0007268 | None | DRD1, DRD2, DRD3, DRD5, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 | 5.00147 |
[BP] GO:0098916 | None | DRD1, DRD2, DRD3, DRD5, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 | 5.00147 |
[BP] GO:0043269 | regulation of ion transport | ADORA1, ADRA2A, BCL2, CA2, CA7, DRD1, DRD2, DRD3, GPR35, GRM5, HTR1A, KCNH2, MMP9, PTAFR, SLC6A4 | 5.00147 |
[BP] GO:0019216 | regulation of lipid metabolic process | ADORA1, ADRA2A, CYP1A1, DRD3, FABP3, FLT3, HCAR2, HMGCR, PPARA, RORC, SRC, TEK | 4.99839 |
[BP] GO:2001225 | regulation of chloride transport | CA2, CA7, GRM5, PTAFR | 4.98085 |
[BP] GO:0097267 | omega-hydroxylase P450 pathway | CYP1A1, CYP1A2, CYP1B1, CYP2C19 | 4.98085 |
[BP] GO:0080090 | regulation of primary metabolic process | ADORA1, ADORA3, ADRA2A, APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, HTR1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIM1, PPARA, PTAFR, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH | 4.96767 |
[BP] GO:0017144 | drug metabolic process | ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, EGFR, HSPA1A | 4.95628 |
[BP] GO:0006720 | isoprenoid metabolic process | AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, EGFR, HMGCR | 4.9403 |
[BP] GO:0099536 | None | DRD1, DRD2, DRD3, DRD5, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 | 4.93048 |
[BP] GO:0099537 | None | DRD1, DRD2, DRD3, DRD5, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 | 4.93048 |
[BP] GO:1900542 | None | ADRA2A, DRD1, DRD2, DRD3, DRD5, ESRRB, GRM3, GRM8, INSR, PPARA | 4.93048 |
[BP] GO:0045787 | positive regulation of cell cycle | APEX1, AURKB, CDC25B, CYP1A1, DRD2, DRD3, DUSP3, EGFR, INSR, SLC6A4, SRC, TERT | 4.92806 |
[BP] GO:0044093 | positive regulation of molecular function | ADORA1, ADRA2A, AURKB, BCL2, CDC25B, DRD2, DRD5, EGFR, ESR1, ESR2, F3, FLT3, GRM1, GRM5, HSPA1A, INSR, MET, MMP9, PTAFR, PTPN1, SMAD3, SRC, TEK, TERT, XDH | 4.91972 |
[BP] GO:0009611 | response to wounding | ACHE, ADORA3, BCL2, CYP1A1, DRD2, DRD5, EGFR, PPARA, SMAD3 | 4.87852 |
[BP] GO:0042325 | regulation of phosphorylation | ADORA1, ADRA2A, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, ESRRB, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, KDR, MMP9, PPARA, PTPN1, SRC, TEK, XDH | 4.84753 |
[BP] GO:0006140 | None | ADRA2A, DRD1, DRD2, DRD3, DRD5, ESRRB, GRM3, GRM8, INSR, PPARA | 4.82896 |
[BP] GO:0003008 | None | ADORA1, ADRA2A, AKR1B1, BCL2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, GRM1, GRM5, GRM8, HMGCR, HTR1A, INSR, KCNH2, PTAFR, SLC6A4, SRC, TEK, TYR | 4.82638 |
[BP] GO:0009892 | negative regulation of metabolic process | ADORA1, ADRA2A, APEX1, AURKB, BCL2, CSNK2A1, CYP2D6, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HCAR2, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TERT, XDH | 4.80064 |
[BP] GO:0098771 | inorganic ion homeostasis | BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, GPR35, GRM1, GRM5, KCNH2, SMAD3 | 4.75888 |
[BP] GO:0018108 | peptidyl-tyrosine phosphorylation | AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK | 4.75867 |
[BP] GO:0048583 | regulation of response to stimulus | ADORA1, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, F3, FABP4, FLT3, GPR35, GRM1, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP2, MMP9, NUAK1, PPARA, PTAFR, PTPN1, SMAD3, SRC, TEK, TERT, XDH | 4.73725 |
[BP] GO:0018212 | peptidyl-tyrosine modification | AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK | 4.7043 |
[BP] GO:0031323 | regulation of cellular metabolic process | ACHE, ADORA1, ADORA3, ADRA2A, APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, HTR1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIM1, PPARA, PTAFR, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH | 4.69504 |
[BP] GO:0009987 | cellular process | ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B2, HSPA1A, HTR1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTAFR, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH | 4.68688 |
[BP] GO:0071417 | cellular response to organonitrogen compound | AKR1B1, APEX1, DRD1, DRD5, EGFR, GRM5, IGF1R, INSR, MMP2, PTAFR, SLC6A4, SRC | 4.67859 |
[BP] GO:0043085 | positive regulation of catalytic activity | ADORA1, ADRA2A, AURKB, BCL2, CDC25B, DRD2, DRD5, EGFR, ESR1, F3, FLT3, GRM1, GRM5, HSPA1A, INSR, PTAFR, PTPN1, SMAD3, SRC, TEK, TERT, XDH | 4.66739 |
[BP] GO:0043271 | negative regulation of ion transport | ADORA1, ADRA2A, BCL2, DRD2, DRD3, GPR35, KCNH2, MMP9 | 4.59579 |
[BP] GO:0033559 | unsaturated fatty acid metabolic process | ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6 | 4.53811 |
[BP] GO:0030817 | None | ADRA2A, DRD1, DRD2, DRD3, DRD5, GRM3, GRM8 | 4.51206 |
[BP] GO:0051171 | regulation of nitrogen compound metabolic process | ADORA1, ADORA3, ADRA2A, APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, HTR1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIM1, PPARA, PTAFR, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH | 4.47899 |
[BP] GO:0042327 | positive regulation of phosphorylation | ADORA1, ADRA2A, BCL2, CDC25B, DRD2, EGFR, ESRRB, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH | 4.47899 |
[BP] GO:1903530 | regulation of secretion by cell | ACHE, ADORA1, ADRA2A, CYP19A1, DRD2, DRD3, EGFR, GRIK5, HCAR2, HMGCR, HTR1A, MMP12, PTAFR, SLC6A4, SRC | 4.46267 |
[BP] GO:0032101 | regulation of response to external stimulus | ADORA1, CYP19A1, DRD1, DRD2, DRD3, EGFR, ESR1, F3, FABP4, HMGCR, KDR, MET, MMP12, PPARA, SMAD3, TEK | 4.44586 |
[BP] GO:0043405 | regulation of MAP kinase activity | ADORA1, ADRA2A, DUSP3, EGFR, FLT3, GRM1, HMGCR, IGF1R, INSR, PTPN1, SRC | 4.44586 |
[BP] GO:0015711 | organic anion transport | CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, FABP3, PPARA, SLC1A1 | 4.44497 |
[BP] GO:0032847 | regulation of cellular pH reduction | BCL2, CA2, CA7 | 4.42754 |
[BP] GO:0007216 | None | GRM1, GRM3, GRM5, GRM8 | 4.41149 |
[BP] GO:0050890 | None | ADORA1, DRD1, DRD2, DRD3, DRD5, EGFR, GRM5, HMGCR, INSR, SLC6A4 | 4.40791 |
[BP] GO:2000021 | regulation of ion homeostasis | ADORA1, BCL2, CA2, CA7, DRD1, DRD2, DRD3, KDR, SRC | 4.39975 |
[BP] GO:0050805 | negative regulation of synaptic transmission | ACHE, ADORA1, DRD1, DRD2, DRD5, SLC6A4 | 4.36867 |
[BP] GO:0043410 | positive regulation of MAPK cascade | ADORA1, ADRA2A, DRD2, EGFR, FLT3, GRM1, HMGCR, INSR, KDR, PTPN1, SRC, TEK, XDH | 4.36867 |
[BP] GO:0006690 | icosanoid metabolic process | ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6 | 4.36372 |
[BP] GO:0023052 | None | ADORA1, DRD1, DRD2, DRD3, DRD5, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, KCNH2, SLC1A1, SLC6A2, TEK | 4.35916 |
[BP] GO:0051247 | positive regulation of protein metabolic process | ADORA1, ADRA2A, BCL2, CDC25B, CSNK2A1, DRD2, EGFR, ESR1, F3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, INSR, KDR, MMP9, PTAFR, PTPN1, SMAD3, SRC, TEK, XDH | 4.35916 |
[BP] GO:1901699 | cellular response to nitrogen compound | AKR1B1, APEX1, DRD1, DRD5, EGFR, GRM5, IGF1R, INSR, MMP2, PTAFR, SLC6A4, SRC | 4.35718 |
[BP] GO:1902532 | negative regulation of intracellular signal transduction | BCL2, DRD2, DRD3, DUSP3, ESR1, HMGCR, HSPA1A, IGF1R, MET, MMP9, PTPN1, SRC, XDH | 4.32393 |
[BP] GO:0044057 | None | ADORA1, ADORA3, ADRA2A, DRD2, DRD3, EGFR, GPR35, GRM1, HCAR2, KCNH2, PTAFR, SLC1A1, SMAD3 | 4.30704 |
[BP] GO:0001963 | None | DRD1, DRD2, DRD3, DRD5 | 4.30505 |
[BP] GO:0001932 | regulation of protein phosphorylation | ADORA1, ADRA2A, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH | 4.30059 |
[BP] GO:0006721 | terpenoid metabolic process | AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, EGFR | 4.30016 |
[BP] GO:0035690 | cellular response to drug | AKR1B1, APEX1, AXL, CYP1B1, DRD1, EGFR, KCNH2, KDR, PTAFR, SRC | 4.29554 |
[BP] GO:0034614 | cellular response to reactive oxygen species | AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC | 4.27665 |
[BP] GO:0043408 | regulation of MAPK cascade | ADORA1, ADRA2A, DRD2, DUSP3, EGFR, FLT3, GRM1, HMGCR, IGF1R, INSR, KDR, PTPN1, SRC, TEK, XDH | 4.22857 |
[BP] GO:0032225 | None | DRD1, DRD2, DRD3, SLC6A4 | 4.19441 |
[BP] GO:0032270 | positive regulation of cellular protein metabolic process | ADORA1, ADRA2A, BCL2, CDC25B, DRD2, EGFR, ESR1, F3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, INSR, KDR, MMP9, PTAFR, PTPN1, SMAD3, SRC, TEK, XDH | 4.18758 |
[BP] GO:0007267 | None | ADORA1, DRD1, DRD2, DRD3, DRD5, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2, TEK | 4.18758 |
[BP] GO:0055080 | cation homeostasis | BCL2, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, GPR35, GRM1, GRM5, KCNH2, SMAD3 | 4.17307 |
[BP] GO:0006468 | protein phosphorylation | AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, SRC, TEK | 4.172 |
[BP] GO:0071704 | organic substance metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD11B1, HSD17B2, HSPA1A, HTR1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTAFR, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH | 4.16317 |
[BP] GO:1900543 | None | ADRA2A, DRD2, DRD3, GRM3, GRM8, PPARA | 4.14303 |
[BP] GO:0007610 | None | BCL2, DRD1, DRD2, DRD3, DRD5, EGFR, GRM1, GRM5, HMGCR, HTR1A, INSR, PPARA, SLC6A4 | 4.14303 |
[BP] GO:0009966 | regulation of signal transduction | ADORA1, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F3, FLT3, GPR35, GRM1, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, TERT, XDH | 4.14153 |
[BP] GO:0051046 | None | ACHE, ADORA1, ADRA2A, CYP19A1, DRD2, DRD3, EGFR, GRIK5, HCAR2, HMGCR, HTR1A, MMP12, PTAFR, SLC6A4, SRC | 4.12915 |
[BP] GO:0006631 | fatty acid metabolic process | ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FABP3, PPARA | 4.12915 |
[BP] GO:0001934 | positive regulation of protein phosphorylation | ADORA1, ADRA2A, BCL2, CDC25B, DRD2, EGFR, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH | 4.12346 |
[BP] GO:0097756 | None | ADORA1, DRD5, HMGCR, HTR1A, SLC6A4 | 4.12346 |
[BP] GO:0045980 | None | ADRA2A, DRD2, DRD3, GRM3, GRM8, PPARA | 4.11932 |
[BP] GO:0030814 | None | ADRA2A, DRD1, DRD2, DRD3, DRD5, GRM3, GRM8 | 4.09683 |
[BP] GO:0009968 | negative regulation of signal transduction | ADRA2A, BCL2, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, TERT, XDH | 4.07946 |
[BP] GO:0043549 | regulation of kinase activity | ADORA1, ADRA2A, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, PTPN1, SRC, TEK | 4.05938 |
[BP] GO:0030802 | None | ADRA2A, DRD1, DRD2, DRD3, DRD5, GRM3, GRM8 | 4.02774 |
[BP] GO:0051047 | None | ACHE, ADORA1, CYP19A1, DRD2, DRD3, EGFR, HCAR2, MMP12, PTAFR, SLC6A4, SRC | 4.02774 |
[BP] GO:0007611 | None | DRD1, DRD2, DRD3, DRD5, EGFR, GRM5, HMGCR, INSR, SLC6A4 | 4.02763 |
[BP] GO:1901564 | organonitrogen compound metabolic process | ACHE, AKR1B1, ALPI, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, F3, FLT3, FUT7, GLO1, HMGCR, HSPA1A, HTR1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A, TYR, XDH | 4.00823 |
[BP] GO:0000302 | response to reactive oxygen species | AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC | 4.00823 |
[BP] GO:0030522 | intracellular receptor signaling pathway | ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, RORC, SRC | 3.99309 |
[BP] GO:0007346 | regulation of mitotic cell cycle | APEX1, AURKB, BCL2, CDC25B, CYP1A1, DRD3, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TERT, TOP2A | 3.96485 |
[BP] GO:0007154 | None | ADORA1, AXL, BCL2, DRD1, DRD2, DRD3, DRD5, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2, TEK | 3.94352 |
[BP] GO:0030818 | None | ADRA2A, DRD2, DRD3, GRM3, GRM8 | 3.88111 |
[BP] GO:0097164 | None | ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2, DRD3, HTR1A | 3.87216 |
[BP] GO:0042391 | None | ADORA1, BCL2, DRD1, GPR35, GRIA2, GRIA4, GRIK5, GRM5, KCNH2, KDR, SRC | 3.85104 |
[BP] GO:0022414 | reproductive process | AKR1B1, ALPL, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, DRD1, DRD5, EGFR, ESR1, ESRRB, HSD17B2, INSR, MMP2, MMP9, PTAFR, SLC6A4, SRC, TOP2A | 3.84908 |
[BP] GO:0045761 | None | ADRA2A, DRD2, DRD3, DRD5, GRM3 | 3.84103 |
[BP] GO:0048660 | regulation of smooth muscle cell proliferation | AKR1B1, EGFR, HMGCR, MMP2, MMP9, PTAFR, TERT | 3.84103 |
[BP] GO:0016098 | monoterpenoid metabolic process | CYP1A2, CYP2C19, CYP2D6 | 3.83438 |
[BP] GO:0042445 | hormone metabolic process | ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD17B2 | 3.83116 |
[BP] GO:0065007 | biological regulation | ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B2, HSPA1A, HTR1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTAFR, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, XDH | 3.82581 |
[BP] GO:1900371 | None | ADRA2A, DRD1, DRD2, DRD3, DRD5, GRM3, GRM8 | 3.82525 |
[BP] GO:0043401 | steroid hormone mediated signaling pathway | ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC | 3.80617 |
[BP] GO:0030808 | None | ADRA2A, DRD1, DRD2, DRD3, DRD5, GRM3, GRM8 | 3.80617 |
[BP] GO:0030803 | None | ADRA2A, DRD2, DRD3, GRM3, GRM8 | 3.80557 |
[BP] GO:1904063 | None | ADRA2A, DRD2, DRD3, GPR35, KCNH2, MMP9 | 3.80122 |
[BP] GO:0055114 | oxidation-reduction process | AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, HMGCR, HSD11B1, HSD17B2, TYR, XDH | 3.79859 |
[BP] GO:0045859 | regulation of protein kinase activity | ADORA1, ADRA2A, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, PTPN1, SRC | 3.7902 |
[BP] GO:0031399 | regulation of protein modification process | ADORA1, ADRA2A, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PTPN1, SRC, TEK, XDH | 3.78874 |
[BP] GO:0038083 | peptidyl-tyrosine autophosphorylation | EGFR, IGF1R, INSR, KDR, SRC | 3.7666 |
[BP] GO:0019373 | epoxygenase P450 pathway | CYP1A1, CYP1A2, CYP1B1, CYP2C19 | 3.76629 |
[BP] GO:0051338 | regulation of transferase activity | ADORA1, ADRA2A, AURKB, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, PTPN1, SRC, TEK | 3.76613 |
[BP] GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SRC, TEK | 3.76538 |
[BP] GO:0030815 | None | ADRA2A, DRD2, DRD3, GRM3, GRM8 | 3.72693 |
[BP] GO:0034599 | cellular response to oxidative stress | AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC | 3.70345 |
[BP] GO:0072507 | divalent inorganic cation homeostasis | BCL2, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, GPR35, GRM1, GRM5, SMAD3 | 3.70345 |
[BP] GO:0007200 | None | ADRA2A, DRD1, DRD2, DRD5, ESR1, GRM5 | 3.70146 |
[BP] GO:0006950 | response to stress | ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD5, EGFR, HSPA1A, HTR1A, MMP2, MMP9, NUAK1, PPARA, PTAFR, PTPN1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A | 3.70146 |
[BP] GO:0007612 | None | DRD1, DRD2, DRD3, DRD5, GRM5, HMGCR, INSR | 3.70146 |
[BP] GO:0035556 | intracellular signal transduction | ADRA2A, AKR1B1, AXL, BCL2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, GRM5, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PTAFR, PTPN1, SRC, TEK | 3.69615 |
[BP] GO:1900372 | None | ADRA2A, DRD2, DRD3, GRM3, GRM8 | 3.69615 |
[BP] GO:0030809 | None | ADRA2A, DRD2, DRD3, GRM3, GRM8 | 3.69615 |
[BP] GO:0009891 | positive regulation of biosynthetic process | AURKB, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, INSR, KDR, MET, MMP12, PPARA, PTAFR, RORC, SMAD3, SRC, TERT, TOP2A | 3.65746 |
[BP] GO:0030800 | None | ADRA2A, DRD2, DRD3, GRM3, GRM8 | 3.65662 |
[BP] GO:0051588 | None | DRD1, DRD2, DRD3, GRIK5, HTR1A, SLC6A4 | 3.62863 |
[BP] GO:0007186 | G-protein coupled receptor signaling pathway | ADORA1, ADORA3, ADRA2A, CA2, DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, INSR, PTAFR, SRC | 3.61831 |
[BP] GO:0051726 | regulation of cell cycle | APEX1, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, DRD2, DRD3, DUSP3, EGFR, HSPA1A, INSR, PIM1, SLC6A4, SMAD3, SRC, TERT, TOP2A | 3.61092 |
[BP] GO:0030799 | None | ADRA2A, DRD1, DRD2, DRD3, DRD5, GRM3, GRM8 | 3.5923 |
[BP] GO:0044238 | primary metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD11B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH | 3.58021 |
[BP] GO:0010676 | None | ESRRB, INSR, PPARA, PTAFR, SRC | 3.58021 |
[BP] GO:0009056 | catabolic process | ACHE, ADORA1, AKR1B10, AOX1, AURKB, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FABP3, FABP4, FUT7, HSPA1A, MMP1, MMP12, MMP2, MMP9, SRC, XDH | 3.56895 |
[BP] GO:0006811 | None | CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD1, DRD2, DRD3, FABP3, GRIA2, GRIA4, GRIK5, KCNH2, PPARA, SLC1A1, SLC6A2, SLC6A4 | 3.5596 |
[BP] GO:0045931 | positive regulation of mitotic cell cycle | APEX1, CDC25B, CYP1A1, DRD3, DUSP3, INSR, TERT | 3.5596 |
[BP] GO:0048856 | anatomical structure development | ACHE, ADORA1, AKR1B1, ALPL, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, INSR, KDR, MMP9, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TYR | 3.53533 |
[BP] GO:0034766 | None | ADRA2A, DRD2, DRD3, GPR35, KCNH2, MMP9 | 3.53357 |
[BP] GO:0034762 | None | ADRA2A, BCL2, CA2, DRD1, DRD2, DRD3, GPR35, GRM5, KCNH2, MMP9, PTAFR | 3.53357 |
[BP] GO:0019369 | arachidonic acid metabolic process | CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6 | 3.50859 |
[BP] GO:0032102 | negative regulation of response to external stimulus | ADORA1, CYP19A1, DRD1, DRD2, DRD3, HMGCR, PPARA, SMAD3, TEK | 3.50555 |
[BP] GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | AURKB, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, IGF1R, INSR, MET, MMP12, PPARA, PTPN1, RORC, SMAD3, SRC, TERT, TOP2A | 3.47191 |
[BP] GO:0008217 | None | ADORA1, DRD2, DRD3, DRD5, PPARA, PTAFR, SMAD3 | 3.47188 |
[BP] GO:0051940 | None | DRD1, DRD2, DRD3 | 3.46164 |
[BP] GO:0051584 | None | DRD1, DRD2, DRD3 | 3.46164 |
[BP] GO:0042752 | None | ADORA1, DRD2, DRD3, PPARA, RORC, TOP2A | 3.44006 |
[BP] GO:0001975 | None | DRD1, DRD2, DRD3, DRD5 | 3.43035 |
[BP] GO:0006820 | anion transport | CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, FABP3, PPARA, SLC1A1 | 3.42647 |
[BP] GO:0055065 | metal ion homeostasis | BCL2, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, GPR35, GRM1, GRM5, KCNH2, SMAD3 | 3.42647 |
[BP] GO:0051897 | positive regulation of protein kinase B signaling | AXL, EGFR, F3, INSR, MET, SRC, TEK | 3.42492 |
[BP] GO:0033674 | positive regulation of kinase activity | ADORA1, ADRA2A, CDC25B, DRD2, EGFR, FLT3, GRM1, GRM5, INSR, PTPN1, SRC, TEK | 3.40513 |
[BP] GO:0034763 | None | ADRA2A, DRD2, DRD3, GPR35, KCNH2, MMP9 | 3.3978 |
[BP] GO:1901568 | fatty acid derivative metabolic process | ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6 | 3.3747 |
[BP] GO:0055082 | cellular chemical homeostasis | BCL2, CA2, CA7, DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, GRIK5, GRM1, GRM5, SMAD3 | 3.36106 |
[BP] GO:0008283 | cell proliferation | ACHE, AURKB, BCL2, CYP1A1, EGFR, ESR1, FLT3, HTR1A, MET, PIM1, SRC, TEK, TYR | 3.35532 |
[BP] GO:0072593 | reactive oxygen species metabolic process | BCL2, CYP1A1, CYP1A2, CYP1B1, DRD5, EGFR | 3.35506 |
[BP] GO:0051701 | interaction with host | AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC | 3.327 |
[BP] GO:0006874 | cellular calcium ion homeostasis | BCL2, DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, GRM1, GRM5, SMAD3 | 3.28699 |
[BP] GO:0032846 | positive regulation of homeostatic process | AURKB, CA2, CA7, DRD1, DRD2, DRD3, EGFR, HCAR2 | 3.28162 |
[BP] GO:0031279 | None | ADRA2A, DRD2, DRD3, DRD5, GRM3 | 3.27781 |
[BP] GO:0060255 | regulation of macromolecule metabolic process | ACHE, ADORA1, ADORA3, ADRA2A, APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, GLO1, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIM1, PPARA, PTAFR, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, XDH | 3.27623 |
[BP] GO:0030003 | cellular cation homeostasis | BCL2, CA2, CA7, DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, GRM1, GRM5, SMAD3 | 3.27503 |
[BP] GO:0031328 | positive regulation of cellular biosynthetic process | AURKB, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, INSR, MET, MMP12, PPARA, PTAFR, RORC, SMAD3, SRC, TERT, TOP2A | 3.27443 |
[BP] GO:0022898 | None | ADRA2A, BCL2, DRD2, DRD3, GPR35, GRM5, MMP9, PTAFR | 3.26053 |
[BP] GO:0051339 | None | ADRA2A, DRD2, DRD3, DRD5, GRM3 | 3.25103 |
[BP] GO:0007167 | enzyme linked receptor protein signaling pathway | AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK | 3.23577 |
[BP] GO:0042542 | response to hydrogen peroxide | AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC | 3.23368 |
[BP] GO:0034754 | cellular hormone metabolic process | AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B2 | 3.23368 |
[BP] GO:0032787 | None | ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FABP3, GLO1, PPARA | 3.22437 |
[BP] GO:0019725 | cellular homeostasis | APEX1, BCL2, CA2, CA7, DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, GRIK5, GRM1, GRM5, SMAD3 | 3.20604 |
[BP] GO:0050794 | regulation of cellular process | ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, APEX1, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, HTR1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTAFR, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, XDH | 3.20383 |
[BP] GO:0031324 | negative regulation of cellular metabolic process | ADRA2A, APEX1, AURKB, BCL2, CSNK2A1, CYP2D6, DRD2, DRD3, DUSP3, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TERT, XDH | 3.20378 |
[BP] GO:0031347 | regulation of defense response | ADORA1, CYP19A1, DRD2, EGFR, ESR1, FABP4, HSPA1A, MMP12, MMP2, PPARA, PTPN1, SMAD3, SRC, TEK | 3.20378 |
[BP] GO:0009755 | hormone-mediated signaling pathway | ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC | 3.19784 |
[BP] GO:0055074 | calcium ion homeostasis | BCL2, DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, GRM1, GRM5, SMAD3 | 3.19648 |
[BP] GO:0006873 | cellular ion homeostasis | BCL2, CA2, CA7, DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, GRM1, GRM5, SMAD3 | 3.19127 |
[BP] GO:0019932 | second-messenger-mediated signaling | ADRA2A, DRD1, DRD2, DRD3, DRD5, EGFR, GRM5, KDR | 3.1872 |
[BP] GO:0007191 | None | DRD1, DRD3, DRD5 | 3.1872 |
[BP] GO:0051347 | positive regulation of transferase activity | ADORA1, ADRA2A, AURKB, CDC25B, DRD2, EGFR, FLT3, GRM1, GRM5, INSR, PTPN1, SRC, TEK | 3.17928 |
[BP] GO:0045744 | None | ADRA2A, DRD2, DRD3, MET | 3.16924 |
[BP] GO:0072503 | cellular divalent inorganic cation homeostasis | BCL2, DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, GRM1, GRM5, SMAD3 | 3.15783 |
[BP] GO:0032268 | regulation of cellular protein metabolic process | ADORA1, ADRA2A, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PTAFR, PTPN1, SMAD3, SRC, TEK, XDH | 3.15604 |
[BP] GO:0031348 | negative regulation of defense response | ADORA1, CYP19A1, DRD2, MMP12, PPARA, SMAD3, TEK | 3.14374 |
[BP] GO:0016310 | phosphorylation | AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, SRC, TEK | 3.14374 |
[BP] GO:0009894 | regulation of catabolic process | ADORA1, ADRA2A, APEX1, BCL2, CSNK2A1, EGFR, ESRRB, HCAR2, HSPA1A, INSR, KDR, MET, PPARA, PTPN1, SMAD3 | 3.13387 |
[BP] GO:0001503 | ossification | ALPL, BCL2, EGFR, MMP2, MMP9, TEK | 3.12476 |
[BP] GO:0007194 | None | ADRA2A, DRD2, DRD3, GRM3 | 3.12288 |
[BP] GO:0032228 | regulation of synaptic transmission, GABAergic | ADORA1, CA2, CA7, DRD2 | 3.12288 |
[BP] GO:0045936 | None | ADRA2A, DRD2, DRD3, DUSP3, FABP4, GRM3, GRM8, HMGCR, IGF1R, PPARA, PTPN1, XDH | 3.12032 |
[BP] GO:0010563 | None | ADRA2A, DRD2, DRD3, DUSP3, FABP4, GRM3, GRM8, HMGCR, IGF1R, PPARA, PTPN1, XDH | 3.11474 |
[BP] GO:0010038 | response to metal ion | BCL2, CA2, CYP1A1, CYP1A2, DRD2, EGFR, FABP4, MMP9, TERT | 3.11474 |
[BP] GO:0032409 | None | ADRA2A, BCL2, DRD2, DRD3, GPR35, GRM5, MMP9, PTAFR | 3.11384 |
[BP] GO:0045913 | None | ESRRB, INSR, PPARA, PTAFR, SRC | 3.09321 |
[BP] GO:0001101 | response to acid chemical | AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTAFR, SLC6A4, SRC | 3.08733 |
[BP] GO:0050789 | regulation of biological process | ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, APEX1, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, HTR1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTAFR, PTPN1, RORC, SLC1A1, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, XDH | 3.08402 |
[BP] GO:0010907 | None | ESRRB, INSR, PPARA, SRC | 3.07939 |
[BP] GO:0042180 | None | AKR1B1, AKR1B10, CYP19A1, GLO1, HMGCR | 3.0682 |
[BP] GO:0071900 | regulation of protein serine/threonine kinase activity | ADORA1, ADRA2A, DUSP3, EGFR, FLT3, GRM1, HMGCR, IGF1R, INSR, PTPN1, SRC | 3.06671 |
[BP] GO:0031280 | None | ADRA2A, DRD2, DRD3, GRM3 | 3.03137 |
[BP] GO:0008306 | None | DRD1, DRD2, DRD3, DRD5, HMGCR | 3.01219 |
[BP] GO:0050806 | positive regulation of synaptic transmission | ADORA1, CA2, CA7, DRD1, DRD2, EGFR | 3.00019 |
[BP] GO:0010675 | None | ESRRB, INSR, PPARA, PTAFR, RORC, SRC | 3.00019 |
[BP] GO:0045860 | positive regulation of protein kinase activity | ADORA1, ADRA2A, CDC25B, DRD2, EGFR, FLT3, GRM1, GRM5, INSR, PTPN1, SRC | 2.98852 |
[BP] GO:0007189 | None | ADRA2A, DRD1, DRD2, DRD3, DRD5 | 2.98852 |
[BP] GO:0021885 | forebrain cell migration | AXL, DRD1, DRD2, EGFR | 2.98852 |
[BP] GO:0015872 | None | DRD1, SLC6A2, SLC6A4 | 2.96638 |
[BP] GO:0051350 | None | ADRA2A, DRD2, DRD3, GRM3 | 2.94126 |
[BP] GO:0046960 | None | DRD1, DRD5 | 2.94048 |
[BP] GO:0009115 | None | AOX1, XDH | 2.94048 |
[BP] GO:0031401 | positive regulation of protein modification process | ADORA1, ADRA2A, BCL2, CDC25B, DRD2, EGFR, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH | 2.91557 |
[BP] GO:0006694 | steroid biosynthetic process | AKR1B1, CES1, CYP19A1, HMGCR, HSD11B1, HSD17B2 | 2.91413 |
[BP] GO:0032413 | None | ADRA2A, DRD2, DRD3, GPR35, MMP9 | 2.91413 |
[BP] GO:0048869 | cellular developmental process | ACHE, ALPL, AXL, BCL2, CDC25B, CES1, CYP1A1, DRD1, DRD2, EGFR, ESR1, ESRRB, FABP4, FLT3, FUT7, GLO1, HMGCR, KDR, MET, MMP2, MMP9, RORC, SMAD3, SRC, TEK, TERT, TOP2A | 2.91413 |
[BP] GO:0007212 | None | DRD1, DRD2, DRD3, DRD5 | 2.90464 |
[BP] GO:0032467 | None | AURKB, CDC25B, DRD2, DRD3 | 2.90464 |
[BP] GO:0006979 | response to oxidative stress | AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, SRC | 2.90223 |
[BP] GO:0051098 | regulation of binding | AURKB, BCL2, CYP2D6, MET, MMP9, PPARA, SMAD3, SRC, TERT | 2.90223 |
[BP] GO:0051952 | None | ADORA1, ADRA2A, DRD1, DRD2, DRD3 | 2.89254 |
[BP] GO:0009895 | negative regulation of catabolic process | ADORA1, ADRA2A, BCL2, EGFR, HCAR2, MET, PPARA, SMAD3 | 2.89254 |
[BP] GO:0046883 | regulation of hormone secretion | ADORA1, ADRA2A, CYP19A1, DRD2, EGFR, HCAR2, HMGCR, HTR1A | 2.89254 |
[BP] GO:0043406 | positive regulation of MAP kinase activity | ADORA1, ADRA2A, EGFR, FLT3, GRM1, INSR, PTPN1, SRC | 2.88187 |
[BP] GO:0060134 | None | DRD1, DRD2, DRD3 | 2.87576 |
[BP] GO:0060158 | None | DRD1, DRD2, DRD5 | 2.87576 |
[BP] GO:0060078 | None | ADORA1, GRIA2, GRIA4, GRIK5, GRM5 | 2.87155 |
[BP] GO:0014075 | None | DRD1, DRD2, DRD3, DRD5 | 2.86915 |
[BP] GO:1901652 | response to peptide | AKR1B1, APEX1, FABP3, GRM5, IGF1R, INSR, PPARA, SRC, TEK | 2.85432 |
[BP] GO:0051172 | None | ADRA2A, APEX1, AURKB, CSNK2A1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HMGCR, HSPA1A, IGF1R, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TERT, XDH | 2.83041 |
[BP] GO:1903532 | None | ACHE, CYP19A1, DRD2, EGFR, HCAR2, MMP12, PTAFR, SLC6A4, SRC | 2.79119 |
[BP] GO:0060065 | uterus development | CYP19A1, ESR1, SRC | 2.78353 |
[BP] GO:0051580 | None | DRD1, DRD2, DRD3 | 2.78353 |
[BP] GO:0090068 | positive regulation of cell cycle process | APEX1, AURKB, CDC25B, CYP1A1, DRD2, DRD3, INSR, TERT | 2.78214 |
[BP] GO:0070372 | regulation of ERK1 and ERK2 cascade | DRD2, DUSP3, EGFR, HMGCR, KDR, PTPN1, SRC, TEK | 2.78214 |
[BP] GO:0018193 | peptidyl-amino acid modification | AURKB, AXL, BCL2, CSNK2A1, DRD1, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK, TOP2A | 2.75854 |
[BP] GO:0002791 | None | ACHE, ADORA1, ADRA2A, DRD2, DRD3, EGFR, HCAR2, HMGCR, MMP12, SRC | 2.75587 |
[BP] GO:0007623 | circadian rhythm | DRD2, DRD3, EGFR, PPARA, RORC, SLC6A4 | 2.75587 |
[BP] GO:0044070 | regulation of anion transport | ADORA1, CA2, CA7, GRM5, PTAFR | 2.75545 |
[BP] GO:0010557 | positive regulation of macromolecule biosynthetic process | AURKB, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, IGF1R, INSR, KDR, MET, MMP12, PPARA, PTAFR, RORC, SMAD3, SRC, TERT, TOP2A | 2.75211 |
[BP] GO:0009889 | regulation of biosynthetic process | ADORA3, ADRA2A, APEX1, AURKB, BCL2, CA9, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, PIM1, PPARA, PTAFR, RORC, SMAD3, SRC, TERT, TOP2A | 2.7487 |
[BP] GO:0032410 | None | ADRA2A, DRD2, DRD3, GPR35, MMP9 | 2.73428 |
[BP] GO:0043268 | None | ADORA1, ADRA2A, DRD1, KCNH2 | 2.71606 |
[BP] GO:0043393 | regulation of protein binding | AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT | 2.71513 |
[BP] GO:0002009 | morphogenesis of an epithelium | BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC | 2.70626 |
[BP] GO:0051937 | None | DRD1, SLC6A2, SLC6A4 | 2.70417 |
[BP] GO:0050877 | None | ADORA1, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, GRM1, GRM5, GRM8, HMGCR, INSR, SLC6A4, TYR | 2.69329 |
[BP] GO:0090066 | None | ADORA1, ADRA2A, DRD1, DRD5, EGFR, HMGCR, HTR1A, PTAFR, SLC6A4 | 2.69128 |
[BP] GO:0006584 | None | AKR1B1, DRD1, DRD2, DRD3 | 2.68565 |
[BP] GO:0009712 | None | AKR1B1, DRD1, DRD2, DRD3 | 2.68565 |
[BP] GO:1903727 | positive regulation of phospholipid metabolic process | FABP3, FLT3, SRC, TEK | 2.68565 |
[BP] GO:0061098 | None | ADORA1, ADRA2A, GRM5, PTPN1 | 2.68565 |
[BP] GO:0009416 | response to light stimulus | AURKB, BCL2, DRD1, DRD2, DRD3, EGFR, HMGCR, TYR | 2.68418 |
[BP] GO:1903522 | None | ADORA1, ADORA3, ADRA2A, DRD2, EGFR, KCNH2, PTAFR, SLC1A1 | 2.68418 |
[BP] GO:0032845 | None | ADORA1, ADRA2A, BCL2, DRD2, HMGCR, SRC | 2.64072 |
[BP] GO:0060359 | None | DRD1, DRD2, DRD3, DRD5, PTAFR | 2.63198 |
[BP] GO:0030540 | female genitalia development | AXL, CYP19A1, ESR1 | 2.63198 |
[BP] GO:0070920 | None | EGFR, ESR1, TERT | 2.63198 |
[BP] GO:0097366 | None | DRD1, DRD2, DRD3, DRD5 | 2.61704 |
[BP] GO:0009410 | None | DRD1, DRD2, DRD3, DRD5, EGFR, PTAFR | 2.61332 |
[BP] GO:0045934 | None | ADRA2A, APEX1, AURKB, DRD2, DRD3, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HSPA1A, MMP12, PPARA, RORC, SMAD3, SRC, TERT | 2.59799 |
[BP] GO:0051246 | regulation of protein metabolic process | ADORA1, ADRA2A, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PTAFR, PTPN1, SMAD3, SRC, TEK, XDH | 2.5891 |
[BP] GO:0019933 | None | ADRA2A, DRD1, DRD2, DRD3, DRD5 | 2.57076 |
[BP] GO:0051130 | positive regulation of cellular component organization | AURKB, AXL, BCL2, DRD2, DRD3, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK | 2.56777 |
[BP] GO:0048545 | response to steroid hormone | ALPL, BCL2, CA2, EGFR, FLT3, PTAFR, SRC | 2.5609 |
[BP] GO:0001504 | None | SLC1A1, SLC6A2, SLC6A4 | 2.55911 |
[BP] GO:0006875 | cellular metal ion homeostasis | BCL2, DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, GRM1, GRM5, SMAD3 | 2.54438 |
[BP] GO:0099566 | None | GRM1, GRM5 | 2.54438 |
[BP] GO:0046110 | None | AOX1, XDH | 2.54438 |
[BP] GO:0060160 | None | DRD2, DRD3 | 2.54438 |
[BP] GO:0032849 | positive regulation of cellular pH reduction | CA2, CA7 | 2.54438 |
[BP] GO:0032412 | None | ADRA2A, DRD2, DRD3, GPR35, GRM5, MMP9, PTAFR | 2.53541 |
[BP] GO:0090087 | None | ACHE, ADORA1, ADRA2A, CA2, DRD2, DRD3, EGFR, HCAR2, HMGCR, MMP12, PTPN1, SMAD3, SRC | 2.53083 |
[BP] GO:0008542 | None | DRD1, DRD2, DRD3, HMGCR | 2.52729 |
[BP] GO:2001243 | negative regulation of intrinsic apoptotic signaling pathway | BCL2, HSPA1A, MMP9, PTPN1, SRC | 2.49898 |
[BP] GO:0031960 | response to corticosteroid | ALPL, BCL2, EGFR, FLT3, PTAFR, SRC | 2.49126 |
[BP] GO:0010906 | None | ESRRB, INSR, PPARA, RORC, SRC | 2.47918 |
[BP] GO:0003006 | developmental process involved in reproduction | ALPL, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, INSR, SRC | 2.47421 |
[BP] GO:0051051 | negative regulation of transport | ADORA1, ADRA2A, BCL2, DRD2, DRD3, GPR35, HMGCR, HSPA1A, KCNH2, MMP9 | 2.47421 |
[BP] GO:0043266 | None | ADORA1, ADRA2A, DRD1, DRD2, KCNH2 | 2.43933 |
[BP] GO:0050730 | None | ADORA1, ADRA2A, EGFR, FLT3, GRM5, PTPN1, SRC | 2.43652 |
[BP] GO:0045187 | None | ADORA1, DRD2, DRD3 | 2.43225 |
[BP] GO:0051900 | regulation of mitochondrial depolarization | BCL2, KDR, SRC | 2.43225 |
[BP] GO:0032147 | activation of protein kinase activity | ADORA1, ADRA2A, DRD2, EGFR, GRM1, INSR, PTPN1, SRC | 2.43108 |
[BP] GO:0043065 | positive regulation of apoptotic process | BCL2, CYP1B1, F3, GRIK5, HCAR2, HMGCR, MMP9, SMAD3, SRC, TOP2A, XDH | 2.43087 |
[BP] GO:0006367 | transcription initiation from RNA polymerase II promoter | ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC | 2.42681 |
[BP] GO:0010564 | regulation of cell cycle process | APEX1, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, DRD2, DRD3, EGFR, HSPA1A, INSR, TERT | 2.42681 |
[BP] GO:0001676 | long-chain fatty acid metabolic process | CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6 | 2.40883 |
[BP] GO:0019935 | None | ADRA2A, DRD1, DRD2, DRD3, DRD5 | 2.40883 |
[BP] GO:0050994 | None | ADORA1, ADRA2A, HCAR2, PPARA | 2.40863 |
[BP] GO:1901617 | organic hydroxy compound biosynthetic process | AKR1B1, CES1, CYP19A1, HMGCR, PTAFR, TYR | 2.40198 |
[BP] GO:0043068 | positive regulation of programmed cell death | BCL2, CYP1B1, F3, GRIK5, HCAR2, HMGCR, MMP9, SMAD3, SRC, TOP2A, XDH | 2.40039 |
[BP] GO:0051828 | entry into other organism involved in symbiotic interaction | AXL, EGFR, HSPA1A, MET, SRC | 2.39473 |
[BP] GO:0030260 | entry into host cell | AXL, EGFR, HSPA1A, MET, SRC | 2.39473 |
[BP] GO:0051806 | entry into cell of other organism involved in symbiotic interaction | AXL, EGFR, HSPA1A, MET, SRC | 2.39473 |
[BP] GO:0044409 | entry into host | AXL, EGFR, HSPA1A, MET, SRC | 2.39473 |
[BP] GO:0010638 | positive regulation of organelle organization | AURKB, BCL2, DRD3, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK | 2.39243 |
[BP] GO:0007632 | None | DRD1, DRD2, DRD3, HMGCR | 2.38335 |
[BP] GO:0035588 | None | ADORA1, ADORA3, PTAFR | 2.38147 |
[BP] GO:0048148 | None | DRD1, DRD2, DRD3 | 2.38147 |
[BP] GO:0035813 | None | ADORA1, DRD2, DRD3 | 2.38147 |
[BP] GO:0043270 | None | ADORA1, ADRA2A, DRD1, DRD2, KCNH2, PTAFR, SLC6A4 | 2.37852 |
[BP] GO:0001952 | regulation of cell-matrix adhesion | BCL2, KDR, SMAD3, SRC, TEK | 2.36155 |
[BP] GO:0051893 | regulation of focal adhesion assembly | KDR, SMAD3, SRC, TEK | 2.3595 |
[BP] GO:0033555 | multicellular organismal response to stress | BCL2, DRD1, HTR1A, SLC6A2 | 2.3595 |
[BP] GO:0090109 | regulation of cell-substrate junction assembly | KDR, SMAD3, SRC, TEK | 2.3595 |
[BP] GO:0048732 | gland development | BCL2, CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR | 2.33789 |
[BP] GO:0032922 | None | DRD2, DRD3, PPARA, RORC | 2.32996 |
[BP] GO:0015844 | None | DRD1, SLC6A2, SLC6A4 | 2.32468 |
[BP] GO:0042749 | None | ADORA1, DRD2, DRD3 | 2.32468 |
[BP] GO:0019752 | carboxylic acid metabolic process | ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FABP3, GLO1, PIM1, PPARA, TYR | 2.32468 |
[BP] GO:2000377 | regulation of reactive oxygen species metabolic process | BCL2, CYP1B1, EGFR, INSR, SMAD3, XDH | 2.32063 |
[BP] GO:0050708 | None | ACHE, ADRA2A, DRD2, DRD3, EGFR, HCAR2, HMGCR, MMP12, SRC | 2.30544 |
[BP] GO:0046686 | response to cadmium ion | CYP1A2, EGFR, MMP9, TERT | 2.30454 |
[BP] GO:0034765 | None | ADRA2A, DRD1, DRD2, DRD3, GPR35, GRM5, KCNH2, MMP9, PTAFR | 2.29587 |
[BP] GO:0006145 | None | AOX1, XDH | 2.29587 |
[BP] GO:0018894 | dibenzo-p-dioxin metabolic process | CYP1A1, CYP1A2 | 2.29587 |
[BP] GO:1903391 | regulation of adherens junction organization | KDR, SMAD3, SRC, TEK | 2.28347 |
[BP] GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | ADORA1, ADRA2A, FLT3, GRM5, PTPN1, SRC | 2.27818 |
[BP] GO:1904707 | positive regulation of vascular smooth muscle cell proliferation | MMP2, MMP9, TERT | 2.27818 |
[BP] GO:0030520 | intracellular estrogen receptor signaling pathway | ESR1, ESR2, SRC | 2.27818 |
[BP] GO:0050995 | None | ADORA1, ADRA2A, HCAR2 | 2.27818 |
[BP] GO:0006109 | regulation of carbohydrate metabolic process | ESRRB, INSR, PPARA, PTAFR, RORC, SRC | 2.26763 |
[BP] GO:0010628 | positive regulation of gene expression | DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, INSR, MET, MMP12, PPARA, PTAFR, RORC, SLC6A4, SMAD3, SRC, TERT, TOP2A | 2.26281 |
[BP] GO:0009991 | response to extracellular stimulus | ALPL, AXL, BCL2, CYP1A1, EGFR, HMGCR, SLC6A4, SRC, TYR | 2.26145 |
[BP] GO:0050793 | regulation of developmental process | AXL, BCL2, CA2, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, ESRRB, F3, HMGCR, INSR, KDR, NUAK1, PIM1, PPARA, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH | 2.26023 |
[BP] GO:0070988 | demethylation | APEX1, CYP1A1, CYP1A2, CYP2D6 | 2.23387 |
[BP] GO:0060341 | regulation of cellular localization | ADRA2A, BCL2, CSNK2A1, DRD1, DRD2, DRD3, EGFR, GRIK5, HMGCR, PTPN1, SMAD3, SRC, TERT | 2.22739 |
[BP] GO:0051953 | None | ADORA1, ADRA2A, DRD2 | 2.22731 |
[BP] GO:0044062 | None | ADORA1, DRD2, DRD3 | 2.22731 |
[BP] GO:0009404 | toxin metabolic process | CYP1A1, CYP1A2, CYP1B1 | 2.22731 |
[BP] GO:0002793 | None | ACHE, ADORA1, DRD2, EGFR, HCAR2, MMP12, SRC | 2.22544 |
[BP] GO:1901654 | None | AKR1B1, CA9, CSNK2A1, EGFR, PTAFR, SRC | 2.22269 |
[BP] GO:0043086 | negative regulation of catalytic activity | ADRA2A, CSNK2A1, DRD2, DRD3, DRD5, DUSP3, FABP4, GRM3, HMGCR, IGF1R, MMP9, PTPN1, SRC | 2.22269 |
[BP] GO:0040008 | regulation of growth | BCL2, CSNK2A1, DRD2, DRD3, EGFR, ESR2, HSPA1A, INSR, PIM1, SLC6A4, SMAD3 | 2.20452 |
[BP] GO:0070301 | cellular response to hydrogen peroxide | AKR1B1, APEX1, AXL, CYP1B1 | 2.18573 |
[BP] GO:0042446 | hormone biosynthetic process | AKR1B1, CYP19A1, HSD11B1, HSD17B2 | 2.18573 |
[BP] GO:0051894 | None | KDR, SMAD3, TEK | 2.17817 |
[BP] GO:0008210 | estrogen metabolic process | CYP19A1, CYP1B1, HSD17B2 | 2.17817 |
[BP] GO:1903409 | reactive oxygen species biosynthetic process | CYP1A1, CYP1A2, CYP1B1 | 2.17817 |
[BP] GO:0050728 | negative regulation of inflammatory response | ADORA1, CYP19A1, PPARA, SMAD3, TEK | 2.17529 |
[BP] GO:0031326 | regulation of cellular biosynthetic process | ADORA3, ADRA2A, APEX1, AURKB, BCL2, CA9, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GRM3, GRM5, GRM8, HSPA1A, IGF1R, INSR, MET, MMP12, PIM1, PPARA, PTAFR, RORC, SMAD3, SRC, TERT, TOP2A | 2.17228 |
[BP] GO:0002521 | leukocyte differentiation | AXL, BCL2, FLT3, FUT7, GLO1, MMP9, RORC | 2.17228 |
[BP] GO:0040011 | locomotion | AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, KDR, MET, MMP1, MMP12, MMP9, PTAFR, SRC, TEK | 2.16734 |
[BP] GO:0010942 | positive regulation of cell death | BCL2, CYP1B1, F3, GRIK5, HCAR2, HMGCR, MMP9, SMAD3, SRC, TOP2A, XDH | 2.16674 |
[BP] GO:0071902 | positive regulation of protein serine/threonine kinase activity | ADORA1, ADRA2A, EGFR, FLT3, GRM1, INSR, PTPN1, SRC | 2.16042 |
[BP] GO:0008610 | lipid biosynthetic process | ACHE, AKR1B1, ALPI, CES1, CSNK2A1, CYP19A1, CYP1A1, HMGCR, HSD11B1, HSD17B2 | 2.15717 |
[BP] GO:0032880 | regulation of protein localization | ACHE, ADRA2A, BCL2, CSNK2A1, DRD2, DRD3, EGFR, HCAR2, HMGCR, MMP12, PTPN1, SMAD3, SRC, TERT | 2.15303 |
[BP] GO:0046888 | None | ADORA1, ADRA2A, DRD2, HMGCR | 2.14182 |
[BP] GO:0030336 | None | ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD2 | 2.13877 |
[BP] GO:0050927 | None | F3, KDR, SMAD3 | 2.13732 |
[BP] GO:0048871 | multicellular organismal homeostasis | ADORA1, AKR1B1, DRD1, DRD2, MET | 2.13732 |
[BP] GO:0048729 | tissue morphogenesis | BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC | 2.13732 |
[BP] GO:0010959 | None | ADORA1, ADRA2A, BCL2, DRD1, DRD2, DRD3, GPR35, KCNH2 | 2.13732 |
[BP] GO:0071396 | cellular response to lipid | AXL, EGFR, ESR1, FLT3, PTAFR, RORC, SLC6A4, SRC | 2.1298 |
[BP] GO:0050795 | None | ADORA1, DRD2, DRD3, HTR1A | 2.12403 |
[BP] GO:0021853 | None | DRD1, DRD2 | 2.12035 |
[BP] GO:0010641 | None | F3, SRC | 2.12035 |
[BP] GO:0090325 | None | DRD2, DRD3 | 2.12035 |
[BP] GO:1904936 | None | DRD1, DRD2 | 2.12035 |
[BP] GO:0042321 | None | ADORA1, DRD2 | 2.12035 |
[BP] GO:0097237 | cellular response to toxic substance | AKR1B1, APEX1, AXL, CYP1B1, KDR | 2.11349 |
[BP] GO:0008150 | biological_process | ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B2, HSPA1A, HTR1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTAFR, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH | 2.11257 |
[BP] GO:0030574 | collagen catabolic process | MMP1, MMP12, MMP2, MMP9 | 2.11073 |
[BP] GO:0051926 | negative regulation of calcium ion transport | ADRA2A, BCL2, DRD2, GPR35 | 2.11073 |
[BP] GO:0048608 | reproductive structure development | AXL, BCL2, CYP19A1, ESR1, HSD17B2, INSR, SRC | 2.11073 |
[BP] GO:0016042 | lipid catabolic process | ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 | 2.11073 |
[BP] GO:0050926 | None | F3, KDR, SMAD3 | 2.1069 |
[BP] GO:0035235 | None | GRIA2, GRIA4, GRIK5 | 2.1069 |
[BP] GO:1903393 | None | KDR, SMAD3, TEK | 2.1069 |
[BP] GO:0019219 | regulation of nucleobase-containing compound metabolic process | ADORA3, ADRA2A, APEX1, AURKB, CA9, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP4, GLO1, GRM3, GRM8, HSPA1A, IGF1R, INSR, MET, MMP12, PIM1, PPARA, PTAFR, PTPN1, RORC, SMAD3, SRC, TERT, TOP2A | 2.08878 |
[BP] GO:0045834 | positive regulation of lipid metabolic process | FABP3, FLT3, PPARA, SRC, TEK | 2.07571 |
[BP] GO:0007584 | response to nutrient | ALPL, CYP1A1, EGFR, HMGCR, SLC6A4, TYR | 2.07565 |
[BP] GO:0014910 | regulation of smooth muscle cell migration | APEX1, BCL2, SRC, TERT | 2.07003 |
[BP] GO:0015908 | None | DRD2, DRD3, FABP3, PPARA | 2.07003 |
[BP] GO:0071229 | cellular response to acid chemical | EGFR, KDR, MMP2, PTAFR, SLC6A4, SRC | 2.06579 |
[BP] GO:0032355 | response to estradiol | CYP1A2, EGFR, ESR1, ESRRA, SLC6A4 | 2.06309 |
[BP] GO:0010634 | positive regulation of epithelial cell migration | KDR, MET, MMP9, SRC, TEK | 2.04816 |
[BP] GO:0032465 | None | AURKB, CDC25B, DRD2, DRD3 | 2.04816 |
[BP] GO:0070374 | positive regulation of ERK1 and ERK2 cascade | DRD2, EGFR, HMGCR, KDR, SRC, TEK | 2.03286 |
[BP] GO:2000146 | None | ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD2 | 2.02769 |
[BP] GO:0060079 | None | ADORA1, GRIA2, GRIA4, GRIK5 | 2.02591 |
[BP] GO:0051254 | None | DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, INSR, MET, MMP12, PPARA, RORC, SMAD3, SRC, TERT, TOP2A | 2.02349 |
[BP] GO:0051482 | None | DRD1, GPR35, GRM1 | 2.02349 |
[BP] GO:0035587 | None | ADORA1, ADORA3, PTAFR | 2.02349 |
[BP] GO:0042417 | None | DRD1, DRD2, DRD3 | 2.02349 |
[BP] GO:0031644 | None | ADORA1, GPR35, GRM1, PTAFR | 2.00624 |
[CC] GO:0005886 | plasma membrane | ACHE, ADORA1, ADORA3, ADRA2A, ALPI, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, F3, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, IGF1R, INSR, KCNH2, KDR, MET, MMP2, PIM1, PTAFR, PTPN1, SLC1A1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT | 7.77045 |
[CC] GO:0031226 | intrinsic component of plasma membrane | ADORA1, ADORA3, ADRA2A, AXL, CA4, DRD1, DRD2, DRD3, DRD5, F3, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR1A, IGF1R, INSR, KDR, MET, PTAFR, SLC1A1, SLC6A2, SLC6A4, TEK | 7.40679 |
[CC] GO:0044459 | plasma membrane part | ADORA1, ADORA3, ADRA2A, AXL, CA2, CA4, CA9, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, IGF1R, INSR, KCNH2, KDR, MET, PTAFR, SLC1A1, SLC6A2, SLC6A4, SRC, TEK | 6.67991 |
[CC] GO:0005887 | integral component of plasma membrane | ADORA1, ADORA3, ADRA2A, AXL, DRD1, DRD2, DRD3, DRD5, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR1A, IGF1R, INSR, KDR, MET, PTAFR, SLC1A1, SLC6A2, SLC6A4, TEK | 6.51415 |
[CC] GO:0098590 | plasma membrane region | ADORA1, ADRA2A, CA2, CA4, CA9, DRD1, DRD2, DRD5, EGFR, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, INSR, MET, SLC1A1, SRC, TEK | 6.49059 |
[CC] GO:0016020 | membrane | ACHE, ADORA1, ADORA3, ADRA2A, ALOX5, ALPI, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, F3, FLT3, FUT7, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B2, HTR1A, IGF1R, INSR, KCNH2, KDR, MET, MMP2, PIM1, PTAFR, PTPN1, SLC1A1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TYR | 5.6529 |
[CC] GO:0044425 | membrane part | ACHE, ADORA1, ADORA3, ADRA2A, ALPI, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, F3, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B2, HTR1A, IGF1R, INSR, KCNH2, KDR, MET, PTAFR, PTPN1, SLC1A1, SLC6A2, SLC6A4, SRC, TEK, TYR | 5.25821 |
[CC] GO:0042734 | None | GRIK5, GRM1, GRM3, GRM5, GRM8 | 3.25103 |
[CC] GO:0043235 | receptor complex | ADRA2A, EGFR, GRIA2, GRIA4, GRIK5, GRM1, IGF1R, INSR, SMAD3 | 3.08733 |
[CC] GO:0005783 | None | ADORA1, APEX1, BCL2, CA4, CES1, CES2, CYP19A1, CYP2D6, FLT3, GRIK5, HMGCR, HSPA1A, KDR, PTPN1, XDH | 3.00732 |
[CC] GO:0016323 | basolateral plasma membrane | ADORA1, ADRA2A, CA2, CA4, CA9, EGFR, TEK | 2.94126 |
[CC] GO:0014069 | None | ADORA1, DRD2, GRIK5, GRM1, GRM3, GRM5, SRC | 2.79416 |
[CC] GO:0099572 | None | ADORA1, DRD2, GRIK5, GRM1, GRM3, GRM5, SRC | 2.79416 |
[CC] GO:0031224 | None | ACHE, ADORA1, ADORA3, ADRA2A, ALPI, ALPL, AXL, CA12, CA14, CA4, CA9, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, F3, FLT3, FUT7, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B2, HTR1A, IGF1R, INSR, KDR, MET, PTAFR, SLC1A1, SLC6A2, SLC6A4, TEK, TYR | 2.66033 |
[CC] GO:0044432 | endoplasmic reticulum part | BCL2, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, EGFR, FLT3, GRIA2, HMGCR, HSD11B1, HSD17B2, PTPN1 | 2.61577 |
[CC] GO:0044456 | None | ACHE, ADORA1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SLC6A4, SRC | 2.54438 |
[CC] GO:0044464 | cell part | ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B2, HSPA1A, HTR1A, IGF1R, INSR, KCNH2, KDR, MET, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTAFR, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH | 2.52666 |
[CC] GO:0031253 | None | ADORA1, CA4, CA9, DRD1, DRD2, DRD5, INSR, SRC | 2.42521 |
[CC] GO:0042995 | cell projection | ADORA1, AKR1B1, CA2, DRD1, DRD2, DRD3, DRD5, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SLC6A2, SLC6A4, SRC, TEK | 2.30267 |
[CC] GO:0016021 | None | ADORA1, ADORA3, ADRA2A, ALPI, ALPL, AXL, CA12, CA14, CA9, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, F3, FLT3, FUT7, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B2, HTR1A, IGF1R, INSR, KDR, MET, PTAFR, SLC1A1, SLC6A2, SLC6A4, TEK, TYR | 2.29028 |
[CC] GO:0043197 | None | ADORA1, DRD2, GRIA2, GRIA4, GRM3 | 2.13732 |
[CC] GO:0120025 | None | ADORA1, AKR1B1, CA2, DRD1, DRD2, DRD5, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SLC6A2, SLC6A4, SRC, TEK | 2.11766 |
[CC] GO:0044309 | None | ADORA1, DRD2, GRIA2, GRIA4, GRM3 | 2.11349 |
[CC] GO:0043005 | None | ADORA1, CA2, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SLC6A2, SLC6A4, SRC | 2.11073 |
[CC] GO:0005789 | endoplasmic reticulum membrane | BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, EGFR, GRIA2, HMGCR, HSD11B1, HSD17B2 | 2.10244 |
[CC] GO:0043227 | membrane-bounded organelle | ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA2, CA4, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GRIA4, GRIK5, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC1A1, SMAD3, SRC, TERT, TOP2A, TYR, XDH | 2.09392 |
[MF] GO:0046914 | transition metal ion binding | ALOX5, ALPI, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SMAD3, TYR, XDH | 13.0637 |
[MF] GO:0038023 | signaling receptor activity | ADORA1, ADORA3, ADRA2A, AXL, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, IGF1R, INSR, KCNH2, KDR, MET, PPARA, PTAFR, RORC, TEK | 13.0637 |
[MF] GO:0004872 | receptor activity | ADORA1, ADORA3, ADRA2A, AXL, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, IGF1R, INSR, KCNH2, KDR, MET, PPARA, PTAFR, RORC, TEK | 11.6465 |
[MF] GO:0060089 | molecular transducer activity | ADORA1, ADORA3, ADRA2A, AXL, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, IGF1R, INSR, KCNH2, KDR, MET, PPARA, PTAFR, RORC, TEK | 11.3422 |
[MF] GO:0004871 | signal transducer activity | ADORA1, ADORA3, ADRA2A, AXL, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, IGF1R, INSR, KCNH2, KDR, MET, PPARA, PTAFR, RORC, SMAD3, TEK | 11.3422 |
[MF] GO:0043167 | ion binding | ACHE, ALOX5, ALPI, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HMGCR, HSPA1A, HTR1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTAFR, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH | 11.1691 |
[MF] GO:0004089 | carbonate dehydratase activity | CA1, CA12, CA14, CA2, CA4, CA7, CA9 | 9.71299 |
[MF] GO:0099600 | transmembrane receptor activity | ADORA1, ADORA3, ADRA2A, AXL, DRD1, DRD2, DRD3, DRD5, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, IGF1R, INSR, KDR, MET, PTAFR, TEK | 8.64686 |
[MF] GO:0004888 | transmembrane signaling receptor activity | ADORA1, ADORA3, ADRA2A, AXL, DRD1, DRD2, DRD3, DRD5, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, IGF1R, INSR, KDR, MET, PTAFR, TEK | 8.64686 |
[MF] GO:0008066 | None | GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 | 7.89283 |
[MF] GO:0043169 | cation binding | ACHE, ALOX5, ALPI, ALPL, AOX1, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DRD5, ESR1, ESR2, ESRRA, ESRRB, GLO1, HTR1A, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A4, SMAD3, TERT, TOP2A, TYR, XDH | 7.80056 |
[MF] GO:0030594 | None | DRD1, DRD2, DRD3, DRD5, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HTR1A | 7.5986 |
[MF] GO:0003824 | catalytic activity | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DUSP3, EGFR, F3, FLT3, FUT7, GLO1, HMGCR, HSD11B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTPN1, SRC, TEK, TERT, TOP2A, TYR, XDH | 7.58059 |
[MF] GO:0004714 | transmembrane receptor protein tyrosine kinase activity | AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK | 7.01325 |
[MF] GO:0008270 | zinc ion binding | ALPI, CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, SMAD3 | 7.00806 |
[MF] GO:0008144 | drug binding | ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DRD5, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, SLC6A4, SRC, TEK, TOP2A | 6.69618 |
[MF] GO:0016835 | carbon-oxygen lyase activity | APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9 | 6.45024 |
[MF] GO:0019199 | transmembrane receptor protein kinase activity | AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK | 6.30416 |
[MF] GO:0016836 | hydro-lyase activity | CA1, CA12, CA14, CA2, CA4, CA7, CA9 | 6.02729 |
[MF] GO:1901338 | None | ADRA2A, DRD1, DRD2, DRD3, DRD5 | 5.41326 |
[MF] GO:0070405 | ammonium ion binding | ACHE, DRD1, DRD2, DRD3, DRD5, HTR1A, SLC6A4 | 5.25473 |
[MF] GO:0005506 | iron ion binding | ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, XDH | 5.21327 |
[MF] GO:0019825 | oxygen binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6 | 5.1523 |
[MF] GO:0070330 | aromatase activity | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 | 5.13002 |
[MF] GO:0044877 | macromolecular complex binding | ACHE, ADORA1, ADRA2A, APEX1, CSNK2A1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SLC6A4, SMAD3, SRC | 5.09708 |
[MF] GO:0032403 | protein complex binding | ACHE, ADORA1, ADRA2A, APEX1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SMAD3, SRC | 5.01825 |
[MF] GO:0046872 | metal ion binding | ALOX5, ALPI, ALPL, AOX1, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A4, SMAD3, TERT, TOP2A, TYR, XDH | 4.98085 |
[MF] GO:0098531 | transcription factor activity, direct ligand regulated sequence-specific DNA binding | ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC | 4.9698 |
[MF] GO:0004879 | nuclear receptor activity | ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC | 4.9698 |
[MF] GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 | 4.90945 |
[MF] GO:0004713 | protein tyrosine kinase activity | AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK | 4.84233 |
[MF] GO:0016491 | oxidoreductase activity | AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, HMGCR, HSD11B1, HSD17B2, TYR, XDH | 4.82207 |
[MF] GO:0016829 | lyase activity | APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1 | 4.79384 |
[MF] GO:0004952 | None | DRD1, DRD2, DRD3, DRD5 | 4.67859 |
[MF] GO:0004497 | monooxygenase activity | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, TYR | 4.59579 |
[MF] GO:0003707 | steroid hormone receptor activity | ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC | 4.54984 |
[MF] GO:0035240 | None | DRD1, DRD2, DRD3, DRD5 | 4.53604 |
[MF] GO:0042802 | identical protein binding | ACHE, ADRA2A, AOX1, BCL2, CSNK2A1, DRD2, EGFR, ESR1, ESR2, FLT3, GRIK5, HMGCR, IGF1R, KCNH2, KDR, MET, MMP9, SLC6A4, SMAD3, TERT, TOP2A, TYR, XDH | 4.3303 |
[MF] GO:0019899 | enzyme binding | ADRA2A, ALPI, AURKB, BCL2, CDC25B, CYP1A1, CYP1A2, CYP2C19, DUSP3, EGFR, ESR1, ESR2, ESRRB, F3, GRM5, HMGCR, HSPA1A, KCNH2, MET, PPARA, PTAFR, PTPN1, SLC6A4, SMAD3, SRC, TEK, TOP2A | 4.30505 |
[MF] GO:0004672 | protein kinase activity | AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, SRC, TEK | 4.00807 |
[MF] GO:0020037 | heme binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, SRC | 3.84103 |
[MF] GO:0016614 | oxidoreductase activity, acting on CH-OH group of donors | AKR1B1, AKR1B10, AOX1, HMGCR, HSD11B1, HSD17B2, XDH | 3.70146 |
[MF] GO:0046906 | tetrapyrrole binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, SRC | 3.66553 |
[MF] GO:0016705 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, TYR | 3.3747 |
[MF] GO:0004930 | None | ADORA1, ADORA3, ADRA2A, DRD1, DRD2, DRD3, DRD5, GPR35, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, PTAFR | 3.34348 |
[MF] GO:0004716 | signal transducer, downstream of receptor, with protein tyrosine kinase activity | EGFR, INSR, KDR | 3.30842 |
[MF] GO:0019902 | phosphatase binding | BCL2, EGFR, HMGCR, MET, PPARA, PTPN1, SMAD3 | 3.23599 |
[MF] GO:0016773 | phosphotransferase activity, alcohol group as acceptor | AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, SRC, TEK | 3.21719 |
[MF] GO:0042803 | protein homodimerization activity | ACHE, ADRA2A, AOX1, BCL2, DRD2, FLT3, HMGCR, KCNH2, SLC6A4, SMAD3, TERT, TOP2A, TYR, XDH | 3.17576 |
[MF] GO:0008395 | steroid hydroxylase activity | CYP19A1, CYP1A1, CYP2C19, CYP2D6 | 3.03137 |
[MF] GO:0038052 | RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding | ESR1, ESR2 | 2.94048 |
[MF] GO:0016301 | kinase activity | AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, SRC, TEK | 2.86286 |
[MF] GO:0046983 | protein dimerization activity | ACHE, ADORA1, ADRA2A, AOX1, AXL, BCL2, DRD2, EGFR, FLT3, HMGCR, KCNH2, SLC6A4, SMAD3, TERT, TOP2A, TYR, XDH | 2.73635 |
[MF] GO:0019900 | None | ADRA2A, AURKB, CDC25B, DUSP3, EGFR, ESR1, GRM5, PTAFR, PTPN1, SMAD3, SRC, TOP2A | 2.73136 |
[MF] GO:0016772 | transferase activity, transferring phosphorus-containing groups | AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, SRC, TEK, TERT | 2.70365 |
[MF] GO:0005496 | steroid binding | ESR1, ESR2, ESRRA, ESRRB, RORC | 2.67558 |
[MF] GO:0016903 | None | AKR1B1, AKR1B10, AOX1, XDH | 2.65089 |
[MF] GO:0019901 | None | ADRA2A, CDC25B, DUSP3, EGFR, ESR1, GRM5, PTAFR, PTPN1, SMAD3, SRC, TOP2A | 2.59666 |
[MF] GO:0048037 | cofactor binding | AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, HMGCR, SRC, XDH | 2.55278 |
[MF] GO:0005330 | None | SLC6A2, SLC6A4 | 2.54438 |
[MF] GO:0099583 | None | GRM1, GRM5 | 2.54438 |
[MF] GO:0047374 | None | CES1, CES2 | 2.54438 |
[MF] GO:0004970 | None | GRIA2, GRIA4, GRIK5 | 2.43225 |
[MF] GO:0005234 | None | GRIA2, GRIA4, GRIK5 | 2.43225 |
[MF] GO:0001223 | transcription coactivator binding | ESR1, PPARA, TERT | 2.38147 |
[MF] GO:0001588 | None | DRD1, DRD5 | 2.29587 |
[MF] GO:0034056 | estrogen response element binding | ESR1, ESR2 | 2.29587 |
[MF] GO:0004971 | None | GRIA2, GRIA4 | 2.29587 |
[MF] GO:0032795 | None | ADORA1, ADRA2A | 2.29587 |
[MF] GO:0009055 | electron transfer activity | AKR1B1, AOX1, CYP19A1, CYP1A2, XDH | 2.28347 |
[MF] GO:0016788 | None | ACHE, ADORA1, ALPI, ALPL, APEX1, CA1, CA2, CDC25B, CES1, CES2, DUSP3, PTPN1 | 2.27236 |
[MF] GO:0005518 | collagen binding | ACHE, MMP12, MMP9, SMAD3 | 2.14182 |
[MF] GO:0097159 | organic cyclic compound binding | ADORA1, ADRA2A, AOX1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HMGCR, HSPA1A, HTR1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, XDH | 2.13877 |
[MF] GO:0035586 | None | ADORA1, ADORA3, PTAFR | 2.13732 |
[MF] GO:0019903 | protein phosphatase binding | BCL2, EGFR, HMGCR, MET, PTPN1 | 2.13732 |
[MF] GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | AKR1B1, AKR1B10, HMGCR, HSD11B1, HSD17B2 | 2.12265 |
[MF] GO:0030284 | estrogen receptor activity | ESR1, ESR2 | 2.12035 |
[MF] GO:0043559 | insulin binding | IGF1R, INSR | 2.12035 |
[MF] GO:0003674 | molecular_function | ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B2, HSPA1A, HTR1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTAFR, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH | 2.11257 |
[MF] GO:0099094 | None | GRIA2, GRIA4, GRIK5, KCNH2 | 2.11073 |
[MF] GO:0008289 | lipid binding | AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, PPARA, PTAFR, RORC | 2.11073 |
[MF] GO:0051721 | None | BCL2, HMGCR, PTPN1 | 2.02349 |
KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
---|---|---|
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | GRIA2, GPR35, GRIK5, PTAFR, HTR1A, GRM1, ADRA2A, GRM3, GRM5, ADORA3, GRM8, ADORA1, DRD1, DRD2, DRD3, DRD5, GRIA4 | 12.3765 |
Nitrogen metabolism_Homo sapiens_hsa00910 | CA12, CA1, CA2, CA4, CA7, CA9, CA14 | 10.4972 |
Ovarian steroidogenesis_Homo sapiens_hsa04913 | ALOX5, INSR, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R | 7.1372 |
Adherens junction_Homo sapiens_hsa04520 | PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R | 7.2718 |
Estrogen signaling pathway_Homo sapiens_hsa04915 | SRC, MMP2, MMP9, ESR1, GRM1, EGFR, ESR2, HSPA1A | 6.476 |
Glutamatergic synapse_Homo sapiens_hsa04724 | GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 | 6.0707 |
cAMP signaling pathway_Homo sapiens_hsa04024 | HCAR2, GRIA2, ADORA1, HTR1A, DRD1, DRD2, PPARA, DRD5, GRIA4 | 5.4217 |
Steroid hormone biosynthesis_Homo sapiens_hsa00140 | HSD11B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 | 5.4217 |
Proteoglycans in cancer_Homo sapiens_hsa05205 | SRC, MMP2, KDR, MMP9, MET, ESR1, EGFR, IGF1R | 4.415 |
Rap1 signaling pathway_Homo sapiens_hsa04015 | SRC, INSR, KDR, TEK, DRD2, MET, EGFR, IGF1R | 4.3283 |
Bladder cancer_Homo sapiens_hsa05219 | SRC, MMP1, MMP2, MMP9, EGFR | 4.8122 |
Gap junction_Homo sapiens_hsa04540 | GRM5, SRC, DRD1, DRD2, GRM1, EGFR | 4.4604 |
Metabolic pathways_Homo sapiens_hsa01100 | AKR1B1, HMGCR, TYR, CYP2C19, CYP19A1, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, ALPI, XDH, CES1 | 3.6942 |
Dopaminergic synapse_Homo sapiens_hsa04728 | GRIA2, DRD1, DRD2, DRD3, DRD5, GRIA4 | 3.6765 |
Pathways in cancer_Homo sapiens_hsa05200 | SMAD3, FLT3, MMP1, MMP2, BCL2, MMP9, MET, EGFR, IGF1R | 3.357 |
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | HSD11B1, CYP2D6, CYP1A2, CYP1A1, CYP1B1 | 3.7167 |
Phospholipase D signaling pathway_Homo sapiens_hsa04072 | GRM3, GRM5, INSR, GRM8, GRM1, EGFR | 3.4859 |
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | SMAD3, MMP2, BCL2, PIM1, F3 | 3.2437 |
Chemical carcinogenesis_Homo sapiens_hsa05204 | HSD11B1, CYP1A2, CYP1A1, CYP1B1, CYP2C19 | 3.587 |
Calcium signaling pathway_Homo sapiens_hsa04020 | GRM5, PTAFR, DRD1, GRM1, EGFR, DRD5 | 3.0911 |
Endocytosis_Homo sapiens_hsa04144 | SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A | 3.0911 |
Tryptophan metabolism_Homo sapiens_hsa00380 | CYP1A2, CYP1A1, AOX1, CYP1B1 | 3.587 |
HIF-1 signaling pathway_Homo sapiens_hsa04066 | INSR, BCL2, TEK, EGFR, IGF1R | 3.2234 |
Serotonergic synapse_Homo sapiens_hsa04726 | CYP2D6, ALOX5, HTR1A, CYP2C19, SLC6A4 | 3.0911 |
Focal adhesion_Homo sapiens_hsa04510 | SRC, KDR, BCL2, MET, EGFR, IGF1R | 2.8837 |
Cocaine addiction_Homo sapiens_hsa05030 | GRM3, GRIA2, DRD1, DRD2 | 3.3316 |
MicroRNAs in cancer_Homo sapiens_hsa05206 | BCL2, PIM1, CYP1B1, MMP9, MET, EGFR, CDC25B | 2.8207 |
Ras signaling pathway_Homo sapiens_hsa04014 | INSR, KDR, TEK, MET, EGFR, IGF1R | 2.656 |
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | INSR, KDR, BCL2, TEK, MET, EGFR, IGF1R | 2.4896 |
FoxO signaling pathway_Homo sapiens_hsa04068 | SMAD3, INSR, GRM1, EGFR, IGF1R | 2.8371 |
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | CYP2D6, CYP1A2, AOX1, CYP2C19 | 2.8955 |
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | GRIA2, GRM5, GRM1, GRIA4 | 2.3509 |
PPAR signaling pathway_Homo sapiens_hsa03320 | FABP3, FABP4, MMP1, PPARA | 2.8955 |
Hepatitis B_Homo sapiens_hsa05161 | SMAD3, SRC, BCL2, MMP9 | 1.9003 |
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | ADORA3, INSR, ADORA1, ADRA2A | 1.7185 |
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | INSR, IGF1R, HSPA1A | 1.9642 |
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | FABP4, INSR, ADORA1 | 2.1076 |
Long-term depression_Homo sapiens_hsa04730 | GRIA2, GRM1, IGF1R | 2.033 |
Amphetamine addiction_Homo sapiens_hsa05031 | GRIA2, DRD1, GRIA4 | 1.95 |
Long-term potentiation_Homo sapiens_hsa04720 | GRIA2, GRM5, GRM1 | 1.95 |
Melanoma_Homo sapiens_hsa05218 | MET, EGFR, IGF1R | 1.9003 |
Central carbon metabolism in cancer_Homo sapiens_hsa05230 | FLT3, MET, EGFR | 1.95 |
Prostate cancer_Homo sapiens_hsa05215 | BCL2, EGFR, IGF1R | 1.67 |
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | FLT3, MMP9, MET, IGF1R | 1.6476 |
Retinol metabolism_Homo sapiens_hsa00830 | CYP1A2, CYP1A1, AOX1 | 1.9559 |
Prolactin signaling pathway_Homo sapiens_hsa04917 | SRC, ESR1, ESR2 | 1.9003 |
GnRH signaling pathway_Homo sapiens_hsa04912 | SRC, MMP2, EGFR | 1.6603 |
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | SRC, MET, EGFR | 1.9416 |
Insulin resistance_Homo sapiens_hsa04931 | PTPN1, INSR, PPARA | 1.4943 |
MAPK signaling pathway_Homo sapiens_hsa04010 | DUSP3, EGFR, CDC25B, HSPA1A | 1.2233 |
Toxoplasmosis_Homo sapiens_hsa05145 | ALOX5, BCL2, HSPA1A | 1.4167 |
Drug metabolism - other enzymes_Homo sapiens_hsa00983 | XDH, CES2, CES1 | 2.3315 |
Sphingolipid signaling pathway_Homo sapiens_hsa04071 | ADORA3, BCL2, ADORA1 | 1.4044 |
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | SMAD3, ESRRB, IGF1R | 1.2333 |
AMPK signaling pathway_Homo sapiens_hsa04152 | INSR, HMGCR, IGF1R | 1.3737 |
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | FLT3, KDR, MET, EGFR | 1.1959 |
Jak-STAT signaling pathway_Homo sapiens_hsa04630 | BCL2, PIM1, AOX1 | 1.1715 |
Epstein-Barr virus infection_Homo sapiens_hsa05169 | CSNK2A1, BCL2, HSPA1A | 0.9523 |
Cholinergic synapse_Homo sapiens_hsa04725 | ACHE, BCL2 | 0.8233 |
Viral carcinogenesis_Homo sapiens_hsa05203 | SRC | 0.2303 |
Huntington's disease_Homo sapiens_hsa05016 | GRM5 | 0.2441 |
Herpes simplex infection_Homo sapiens_hsa05168 | CSNK2A1 | 0.2506 |
Purine metabolism_Homo sapiens_hsa00230 | XDH | 0.2622 |
Measles_Homo sapiens_hsa05162 | CSNK2A1, HSPA1A | 0.7176 |
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | CDC25B, IGF1R | 0.9115 |
Chemokine signaling pathway_Homo sapiens_hsa04062 | SRC | 0.2503 |
Influenza A_Homo sapiens_hsa05164 | HSPA1A | 0.2622 |
ErbB signaling pathway_Homo sapiens_hsa04012 | SRC, EGFR | 0.9662 |
Cell cycle_Homo sapiens_hsa04110 | SMAD3, CDC25B | 0.7612 |
Hepatitis C_Homo sapiens_hsa05160 | PPARA, EGFR | 0.7291 |
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | SRC, ESR1 | 0.7926 |
Leukocyte transendothelial migration_Homo sapiens_hsa04670 | MMP2, MMP9 | 0.7926 |
Parkinson's disease_Homo sapiens_hsa05012 | DRD1, DRD2 | 0.7156 |
Insulin signaling pathway_Homo sapiens_hsa04910 | PTPN1, INSR | 0.7162 |
Taste transduction_Homo sapiens_hsa04742 | HTR1A, GRM1 | 0.997 |
Tight junction_Homo sapiens_hsa04530 | CSNK2A1, SRC | 0.7162 |
Hippo signaling pathway_Homo sapiens_hsa04390 | SMAD3 | 0.2984 |
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | INSR, IGF1R | 0.9333 |
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | BCL2 | 0.3059 |
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | BCL2, HSPA1A | 0.6251 |
Morphine addiction_Homo sapiens_hsa05032 | ADORA1, DRD1 | 0.9477 |
Wnt signaling pathway_Homo sapiens_hsa04310 | SMAD3, CSNK2A1 | 0.7156 |
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | INSR, PPARA | 0.6824 |
Apoptosis_Homo sapiens_hsa04210 | BCL2 | 0.3205 |
Circadian entrainment_Homo sapiens_hsa04713 | GRIA2, GRIA4 | 0.9303 |
Tuberculosis_Homo sapiens_hsa05152 | SRC, BCL2 | 0.5941 |
Alcoholism_Homo sapiens_hsa05034 | DRD1, DRD2 | 0.5941 |
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | SRC, EGFR | 0.5117 |
Rheumatoid arthritis_Homo sapiens_hsa05323 | MMP1, TEK | 0.9508 |
Spliceosome_Homo sapiens_hsa03040 | HSPA1A | 0.3316 |
Oxytocin signaling pathway_Homo sapiens_hsa04921 | SRC, EGFR | 0.6592 |
HTLV-I infection_Homo sapiens_hsa05166 | SMAD3, TERT | 0.4358 |
NF-kappa B signaling pathway_Homo sapiens_hsa04064 | CSNK2A1, BCL2 | 0.9363 |
Platelet activation_Homo sapiens_hsa04611 | SRC | 0.3538 |
Axon guidance_Homo sapiens_hsa04360 | MET | 0.3462 |
Neurotrophin signaling pathway_Homo sapiens_hsa04722 | BCL2 | 0.3561 |
Oocyte meiosis_Homo sapiens_hsa04114 | IGF1R | 0.3538 |
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | SRC, MET | 1.04 |
TNF signaling pathway_Homo sapiens_hsa04668 | MMP9 | 0.3824 |
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | SMAD3 | 0.3986 |
Melanogenesis_Homo sapiens_hsa04916 | TYR | 0.4057 |
Choline metabolism in cancer_Homo sapiens_hsa05231 | EGFR | 0.4057 |
Glucagon signaling pathway_Homo sapiens_hsa04922 | PPARA | 0.4057 |
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | SRC | 0.407 |
Glycerophospholipid metabolism_Homo sapiens_hsa00564 | ACHE | 0.4118 |
VEGF signaling pathway_Homo sapiens_hsa04370 | SRC, KDR | 1.1878 |
Pancreatic secretion_Homo sapiens_hsa04972 | CA2 | 0.4113 |
Acute myeloid leukemia_Homo sapiens_hsa05221 | FLT3, PIM1 | 1.2169 |
Glioma_Homo sapiens_hsa05214 | EGFR, IGF1R | 1.167 |
Hematopoietic cell lineage_Homo sapiens_hsa04640 | FLT3 | 0.4295 |
TGF-beta signaling pathway_Homo sapiens_hsa04350 | SMAD3 | 0.4358 |
GABAergic synapse_Homo sapiens_hsa04727 | SRC | 0.4295 |
Pancreatic cancer_Homo sapiens_hsa05212 | SMAD3, EGFR | 1.1605 |
Bile secretion_Homo sapiens_hsa04976 | CA2, HMGCR | 1.1083 |
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | CSNK2A1 | 0.4286 |
Small cell lung cancer_Homo sapiens_hsa05222 | BCL2 | 0.4313 |
Protein digestion and absorption_Homo sapiens_hsa04974 | SLC1A1 | 0.4278 |
Peroxisome_Homo sapiens_hsa04146 | XDH | 0.4358 |
Colorectal cancer_Homo sapiens_hsa05210 | SMAD3, BCL2 | 1.187 |
Chronic myeloid leukemia_Homo sapiens_hsa05220 | SMAD3 | 0.4678 |
Glycerolipid metabolism_Homo sapiens_hsa00561 | AKR1B10, AKR1B1 | 1.202 |
Complement and coagulation cascades_Homo sapiens_hsa04610 | F3 | 0.4489 |
Antigen processing and presentation_Homo sapiens_hsa04612 | HSPA1A | 0.4549 |
Gastric acid secretion_Homo sapiens_hsa04971 | CA2 | 0.4662 |
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | SMAD3, RORC | 1.167 |
Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.4799 |
Arachidonic acid metabolism_Homo sapiens_hsa00590 | ALOX5, CYP2C19 | 1.187 |
Renal cell carcinoma_Homo sapiens_hsa05211 | MET | 0.4985 |
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | GRIA2, BCL2 | 1.287 |
Renin secretion_Homo sapiens_hsa04924 | ADORA1 | 0.5031 |
Shigellosis_Homo sapiens_hsa05131 | SRC | 0.5007 |
Non-small cell lung cancer_Homo sapiens_hsa05223 | EGFR | 0.5468 |
Staphylococcus aureus infection_Homo sapiens_hsa05150 | PTAFR | 0.5468 |
Legionellosis_Homo sapiens_hsa05134 | HSPA1A | 0.5468 |
Endometrial cancer_Homo sapiens_hsa05213 | EGFR | 0.5646 |
Nicotine addiction_Homo sapiens_hsa05033 | GRIA2, GRIA4 | 1.4588 |
Malaria_Homo sapiens_hsa05144 | MET | 0.584 |
Type II diabetes mellitus_Homo sapiens_hsa04930 | INSR | 0.5884 |
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | ESR1 | 0.5891 |
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | AOX1 | 0.5884 |
Galactose metabolism_Homo sapiens_hsa00052 | AKR1B10, AKR1B1 | 1.6536 |
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | INSR | 0.6434 |
Tyrosine metabolism_Homo sapiens_hsa00350 | AOX1, TYR | 1.5476 |
Linoleic acid metabolism_Homo sapiens_hsa00591 | CYP1A2, CYP2C19 | 1.6657 |
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | AKR1B10, AKR1B1 | 1.5317 |
Prion diseases_Homo sapiens_hsa05020 | HSPA1A | 0.6788 |
Pyruvate metabolism_Homo sapiens_hsa00620 | GLO1 | 0.6373 |
Fructose and mannose metabolism_Homo sapiens_hsa00051 | AKR1B10, AKR1B1 | 1.6153 |
Dorso-ventral axis formation_Homo sapiens_hsa04320 | EGFR | 0.7326 |
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | FUT7 | 0.7156 |
Base excision repair_Homo sapiens_hsa03410 | APEX1 | 0.6944 |
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | CA2, CA4 | 1.8377 |
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | AOX1 | 0.7169 |
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | FUT7 | 0.7387 |
Circadian rhythm_Homo sapiens_hsa04710 | RORC | 0.7162 |
Collecting duct acid secretion_Homo sapiens_hsa04966 | CA2 | 0.7326 |
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | HMGCR | 0.7926 |
Folate biosynthesis_Homo sapiens_hsa00790 | ALPL, ALPI | 2.1459 |
Caffeine metabolism_Homo sapiens_hsa00232 | CYP1A2, XDH | 2.9527 |
Vitamin B6 metabolism_Homo sapiens_hsa00750 | AOX1 | 1.215 |