TCM Prescription: Xian Zheng Zhen Xin Pills



Prescription Description
Prescription IDTCMF5962
Pinyin NameXian Zheng Zhen Xin Wan
Chinese Name痫症镇心丸
English NameXian Zheng Zhen Xin Pills
Function Description癫痫, 痴呆
IndicationsDementia disorder, Dementia, Epilepsy
Disease ICD-11 Category SD86 [Dementia disorder (TM1), 痴呆 (TM1) ];
6D8Z [Dementia, unknown or unspecified cause, 痴呆，原因未知或未特定 ];
8A6Z [Epilepsy or seizures, unspecified, 癫痫或癫痫发作，未特指的 ];
Human Tissues Associated with IndicationBrain, Heart
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1997 Bubalus bubalis 水牛角 TCMH1997 GBMA0080-06
TCMH2605 Margarita 珍珠 TCMH2605
TCMH1920 Acorus tatarinowii 石菖蒲 TCMH1920 ITSAI4409-14
TCMH972 Coptis chinensis 黄连 TCMH972 ITSAO4469-14
TCMH1423 Ophiopogon japonicus 麦冬 TCMH1423 ITSAJ4140-14
TCMH2554 Polygala tenuifolia 远志 TCMH2554 MF096619
TCMH404 Rhizoma arisaema cum bile 胆南星 TCMH404
TCMH1573 Bovis calculus 牛黄 TCMH1573
TCMH2682 Cinnabaris 朱砂 TCMH2682
TCMH2052 Ziziphus jujuba var. spinosa 酸枣仁 TCMH2052 ITSAM943-14
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT243 ADRA2C Alpha-2c adrenergic receptor GPCR P18825
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT273 NR1H4 Bile acid receptor FXR Nuclear receptor Q96RI1
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT588 DAO D-amino-acid oxidase Oxidoreductase P14920
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT594 PTAFR Platelet activating factor receptor GPCR P25105
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT69 THRB Thyroid hormone receptor beta-1 Nuclear receptor P10828
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT796 PCNA Proliferating cell nuclear antigen Unclassified P12004
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT864 THRA Thyroid hormone receptor alpha Nuclear receptor P10827
TCMT907 FDPS Farnesyl diphosphate synthase Lyase P14324
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1177 Haemophilus influenzae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1193 Staphylococcus
TCMT1194 Shigella sonnei
TCMT1195 Streptococcus pasteurianus
TCMT1196 Salmonella
TCMT1197 Shigella sp.
TCMT1198 Serratia marcescens
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1305 Salmonella enteritidis
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1385 Candida shehatae
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, FDPS, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NR1H4 12.3378
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, ESR1, F3, FABP3, FABP4, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NR1H4, PPARA, PTAFR, SLC1A1, THRA, THRB, TNKS, TNKS2, XDH 10.8971
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, FABP3, FABP4, FDPS, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NR1H4, PPARA 8.81183
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DAO, DRD1, FDPS, GBA2, HMGCR, NR1H4, PTAFR, TYR 8.33933
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NR1H4 8.33933
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 7.78278
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, AOX1, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, FABP3, FDPS, FUT7, GBA2, HMGCR, NR1H4, PPARA, PTAFR, TYR, XDH 7.0891
[BP] GO:0007215 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.05819
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, BCL2, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRA, FABP3, GRIK5, GRM5, HMGCR, HSD11B2, HSD17B2, NR1H4, PPARA, PTAFR, TYR 7.00486
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, FDPS, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.73294
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.68784
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.22341
[BP] GO:0010033 response to organic substance ADRA2A, AKR1B1, ALPL, BCL2, CA2, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRA, FABP3, FABP4, GRIK5, GRM5, HMGCR, HSD11B2, HSD17B2, NR1H4, PPARA, PTAFR, TYR 5.98547
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 5.96794
[BP] GO:0033993 response to lipid ALPL, BCL2, CA2, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, NR1H4, PTAFR, TYR 5.64651
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7 5.51863
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR1H4, PPARA, THRA, THRB 5.38853
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 5.31
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.19033
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5, PTAFR 5.01916
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, DRD1, GRIK5, GRM1, GRM3, GRM5, GRM8 4.89046
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, DRD1, GRIK5, GRM1, GRM3, GRM5, GRM8 4.89046
[BP] GO:0007188 None ADORA1, ADRA2A, ADRA2C, DRD1, GRM1, GRM3, GRM5, GRM8 4.89046
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, GRM1, GRM3, GRM5, GRM8 4.87933
[BP] GO:0009719 response to endogenous stimulus ADRA2A, AKR1B1, ALPL, BCL2, CA2, CSNK2A1, CYP1A2, DRD1, ESR1, ESRRA, FABP3, GRM5, HSD11B2, NR1H4, PPARA, PTAFR 4.87039
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, NR1H4, PPARA, THRA, THRB 4.83598
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, CYP19A1, CYP3A4, DAO, FDPS, HMGCR, PTAFR, TYR 4.80389
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR1H4, PPARA, THRA, THRB 4.71083
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR1H4, PPARA, THRA, THRB 4.56257
[BP] GO:0009725 response to hormone ADRA2A, AKR1B1, ALPL, BCL2, CA2, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, HSD11B2, PPARA, PTAFR 4.48429
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.47567
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7 4.47533
[BP] GO:0007187 None ADORA1, ADRA2A, ADRA2C, DRD1, GRM1, GRM3, GRM5, GRM8 4.46557
[BP] GO:0042221 response to chemical ADRA2A, AKR1B1, ALPL, BCL2, CA2, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRA, FABP3, FABP4, GRIK5, GRM5, HMGCR, HSD11B2, HSD17B2, NR1H4, PPARA, PTAFR, TYR 4.44938
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, FDPS, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.44795
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FDPS, HMGCR 4.39508
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.39188
[BP] GO:0007193 None ADORA1, ADRA2A, GRM1, GRM3, GRM5, GRM8 4.36887
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, GBA2 4.35498
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADRA2A, BCL2, CA2, CA7, CDK6, DRD1, HMGCR, NR1H4, TNKS, TNKS2 4.21442
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, NR1H4, PPARA, THRA, THRB 4.16708
[BP] GO:0061098 None ADORA1, ADRA2A, ADRA2C, GRM5, PTPN1 4.16708
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRA, HSD11B2, PTAFR, TYR 4.1262
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA2A, ADRA2C, AKR1B1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, F3, GRM1, HMGCR, NR1H4, PTPN1, TNKS, TNKS2, XDH 4.1262
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA2A, ADRA2C, AKR1B1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, F3, GRM1, HMGCR, NR1H4, PTPN1, TNKS, TNKS2, XDH 4.10406
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, GRIK5, GRM1, GRM5, HMGCR, NR1H4, PPARA, PTAFR, PTPN1, THRA, THRB, TNKS, TNKS2, XDH 4.0965
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, GRIK5, GRM1, GRM5, HMGCR, NR1H4, PPARA, PTAFR, PTPN1, SLC1A1, THRA, THRB, TNKS, TNKS2, XDH 3.90741
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, ESR1, ESR2, F3, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, NR1H4, PTPN1, THRA, TNKS, TNKS2, XDH 3.84459
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, FABP3, NR1H4, PPARA, SLC1A1 3.8323
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA2A, ADRA2C, BCL2, CDC25B, DRD1, ESRRB, FABP3, FABP4, GRM1, GRM3, GRM5, GRM8, HMGCR, NR1H4, PPARA, PTAFR, PTPN1, XDH 3.8145
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA2A, ADRA2C, BCL2, CDC25B, DRD1, ESRRB, FABP3, FABP4, GRM1, GRM3, GRM5, GRM8, HMGCR, NR1H4, PPARA, PTAFR, PTPN1, XDH 3.7726
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, ESR1, ESR2, F3, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, NR1H4, PTPN1, THRA, TNKS, TNKS2, XDH 3.76579
[BP] GO:0048878 chemical homeostasis ADRA2A, AKR1B1, BCL2, CA12, CA2, CA7, DRD1, ESR1, FABP3, FABP4, GRIK5, GRM1, GRM5, NR1H4 3.70269
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA2A, ADRA2C, AKR1B1, AKR1B10, ALPL, BCL2, CYP19A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRB, F3, FABP4, GRM1, GRM5, GRM8, HMGCR, HSD11B2, HSD17B2, PPARA, PTAFR, THRA, THRB, TNKS2, TYR 3.68211
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA2A, ADRA2C, BCL2, CDC25B, DRD1, ESRRB, FABP3, GRM1, GRM5, HMGCR, NR1H4, PTAFR, PTPN1, XDH 3.68211
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA2A, ADRA2C, BCL2, CDC25B, DRD1, ESRRB, FABP3, GRM1, GRM5, HMGCR, NR1H4, PTAFR, PTPN1, XDH 3.68211
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.67448
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FDPS 3.63146
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FDPS, FUT7, GBA2, HMGCR, PPARA 3.62654
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, ADRA2A, CYP1A1, FABP3, FDPS, HMGCR, NR1H4, PPARA, THRA 3.45395
[BP] GO:0048513 animal organ development ACHE, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, HSD11B1, HSD17B2, PPARA, THRA, TYR 3.33425
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA2A, ADRA2C, BCL2, CDC25B, CSNK2A1, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, GRM1, GRM5, HMGCR, NR1H4, PPARA, PTAFR, PTPN1, THRA, THRB, TNKS, TNKS2, XDH 3.33398
[BP] GO:0097746 None ADORA1, ADRA2A, ADRA2C, DRD1, HMGCR, PTAFR 3.31463
[BP] GO:0035296 None ADORA1, ADRA2A, ADRA2C, DRD1, HMGCR, PTAFR 3.31463
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, BCL2, CA1, CA2, CDK6, CSNK2A1, CYP1B1, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, NR1H4, PPARA, PTAFR, PTPN1, THRA, THRB, TNKS, TNKS2 3.28355
[BP] GO:1903522 None ADORA1, ADORA3, ADRA2A, ADRA2C, PTAFR, SLC1A1, THRA, THRB 3.28181
[BP] GO:0003008 None ADORA1, ADRA2A, ADRA2C, AKR1B1, BCL2, CYP1B1, DRD1, GRM1, GRM5, GRM8, HMGCR, HSD11B2, PTAFR, THRA, THRB, TYR 3.22754
[BP] GO:0050880 None ADORA1, ADRA2A, ADRA2C, DRD1, HMGCR, PTAFR 3.17981
[BP] GO:0061097 None ADORA1, ADRA2A, ADRA2C, GRM5, PTPN1 3.17981
[BP] GO:0035150 None ADORA1, ADRA2A, ADRA2C, DRD1, HMGCR, PTAFR 3.17404
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.17404
[BP] GO:0051930 None ADORA1, ADRA2C, GRM1, PTAFR 3.15594
[BP] GO:0051931 None ADORA1, ADRA2C, GRM1, PTAFR 3.15594
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5 3.11923
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA2A, ADRA2C, BCL2, CDC25B, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, GRM1, GRM5, HMGCR, NR1H4, PPARA, PTAFR, PTPN1, THRA, THRB, TNKS, TNKS2, XDH 3.10532
[BP] GO:0018958 None AKR1B1, BCL2, DAO, DRD1, TYR 3.09951
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DRD1 3.09762
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA2A, ADRA2C, BCL2, CDC25B, CSNK2A1, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, GRM1, GRM5, HMGCR, NR1H4, PPARA, PTAFR, PTPN1, THRA, THRB, TNKS, TNKS2, XDH 3.0804
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA2A, ADRA2C, BCL2, CDC25B, CSNK2A1, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, GRM1, GRM5, HMGCR, NR1H4, PPARA, PTAFR, PTPN1, THRA, THRB, TNKS, TNKS2, XDH 3.0804
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, BCL2, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD1, F3, GRIK5, GRM5, HMGCR, NR1H4, PPARA, PTAFR, PTPN1, THRA 3.03783
[BP] GO:0032845 None ADORA1, ADRA2A, BCL2, HMGCR, TNKS, TNKS2 3.01711
[BP] GO:0044070 regulation of anion transport ADORA1, CA2, CA7, GRM5, PTAFR 3.01541
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, FABP3, NR1H4, PPARA, SLC1A1 2.99918
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, BCL2, CA1, CA12, CA2, CA4, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NR1H4, PPARA, PTAFR, PTPN1, THRA, THRB, TNKS, TNKS2, TYR, XDH 2.99204
[BP] GO:0045741 None ADORA1, ADRA2A, ADRA2C 2.96754
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.86976
[BP] GO:0046165 None AKR1B1, CYP3A4, FDPS, HMGCR, PTAFR 2.86976
[BP] GO:0003018 None ADORA1, ADRA2A, ADRA2C, DRD1, HMGCR, PTAFR 2.86976
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, BCL2, CA2, CYP1A1, DRD1, GRM1, HMGCR, HSD11B2, PPARA, PTAFR, THRA, TYR 2.84302
[BP] GO:0008050 None THRA, THRB 2.81352
[BP] GO:0009115 None AOX1, XDH 2.81352
[BP] GO:0022414 reproductive process ADRA2C, AKR1B1, ALPL, BCL2, CDC25B, CYP19A1, CYP1A1, DRD1, ESR1, ESRRB, HSD11B2, HSD17B2, PTAFR, THRA, THRB 2.7823
[BP] GO:0042592 homeostatic process ADORA1, ADRA2A, AKR1B1, BCL2, CA12, CA2, CA7, DRD1, ESR1, FABP3, FABP4, GRIK5, GRM1, GRM5, NR1H4 2.77027
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, ALPL, BCL2, CDK6, CYP1A1, CYP1B1, DRD1, ESR1, FABP4, GRIK5, GRM5, NR1H4, PTAFR 2.65698
[BP] GO:0007267 None ADORA1, ADRA2C, DRD1, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 2.5351
[BP] GO:0050994 None ADORA1, ADRA2A, PPARA, THRA 2.52213
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DAO, DRD1 2.52213
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GRM3, GRM8, HMGCR, NR1H4, PPARA, PTPN1, THRA, THRB, TNKS, TNKS2, XDH 2.50772
[BP] GO:0006066 None AKR1B1, AKR1B10, CYP1B1, CYP3A4, FDPS, HMGCR, PTAFR 2.50762
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.49042
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA2A, AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, ESR1, ESRRA, F3, FABP3, HMGCR, PTAFR, XDH 2.4871
[BP] GO:0007617 None DRD1, THRA, THRB 2.43155
[BP] GO:0044057 None ADORA1, ADORA3, ADRA2A, ADRA2C, GRM1, PTAFR, SLC1A1, THRA, THRB 2.43013
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ADRA2A, ADRA2C, BCL2, CA2, CA7, CYP19A1, DRD1, GRIK5, GRM5, HMGCR, NR1H4, PPARA, PTAFR, PTPN1, THRA 2.43013
[BP] GO:1901360 None ACHE, AKR1B1, AKR1B10, AOX1, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DRD1, ESR1, ESR2, ESRRA, ESRRB, FDPS, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NR1H4, PPARA, THRA, THRB, TYR, XDH 2.43013
[BP] GO:0099566 None GRM1, GRM5 2.43013
[BP] GO:0046110 None AOX1, XDH 2.43013
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.43013
[BP] GO:0006808 regulation of nitrogen utilization BCL2, NR1H4 2.43013
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA7, DRD1, FABP3, GRIA2, GRIA4, GRIK5, NR1H4, PPARA, SLC1A1 2.4126
[BP] GO:0007268 None DRD1, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 2.4126
[BP] GO:0098916 None DRD1, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 2.4126
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, ALPL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, GRIK5, GRM5, NR1H4, PTAFR 2.4126
[BP] GO:0035588 None ADORA1, ADORA3, PTAFR 2.41144
[BP] GO:0050801 ion homeostasis BCL2, CA12, CA2, CA7, DRD1, ESR1, FABP3, GRM1, GRM5, NR1H4 2.38383
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA2A, ADRA2C, BCL2, CDC25B, CSNK2A1, DRD1, ESR1, F3, FABP4, GRM1, GRM3, GRM5, HMGCR, PTAFR, PTPN1, TNKS, XDH 2.38303
[BP] GO:0099536 None DRD1, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 2.36353
[BP] GO:0099537 None DRD1, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 2.36353
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.35825
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA2A, ADRA2C, AKR1B1, BCL2, CSNK2A1, CYP1B1, F3, GRM1, HMGCR, NR1H4, PTPN1, TNKS, TNKS2, XDH 2.33547
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALPL, AOX1, BCL2, CA1, CA12, CA2, CA4, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DRD1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FDPS, FUT7, GBA2, HMGCR, HSD17B1, HSD17B2, NR1H4, PPARA, PTAFR, PTPN1, THRA, THRB, TNKS, TNKS2, TYR, XDH 2.33523
[BP] GO:0003013 None ADORA1, ADRA2A, ADRA2C, DRD1, HMGCR, PTAFR 2.33147
[BP] GO:0046888 None ADORA1, ADRA2A, ADRA2C, HMGCR 2.2961
[BP] GO:0023052 None ADORA1, ADRA2C, DRD1, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 2.26031
[BP] GO:0051953 None ADORA1, ADRA2A, ADRA2C 2.26031
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.26031
[BP] GO:0006940 None ADORA1, ADRA2A, ADRA2C, PTAFR 2.2594
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, FABP3, FABP4, FUT7, GBA2, XDH 2.23147
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, BCL2, CA1, CSNK2A1, F3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, NR1H4, PTAFR, PTPN1, TNKS, TNKS2 2.22021
[BP] GO:0008299 None CYP1A1, FDPS, HMGCR 2.2176
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.2176
[BP] GO:0035625 None ADRA2A, ADRA2C 2.2176
[BP] GO:0032811 None ADRA2A, ADRA2C 2.2176
[BP] GO:0070213 None TNKS, TNKS2 2.2176
[BP] GO:0006145 None AOX1, XDH 2.2176
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.2176
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA2A, ADRA2C, AKR1B1, BCL2, CSNK2A1, CYP1B1, ESRRA, F3, FABP4, GRM1, HMGCR, NR1H4, PTAFR, PTPN1, TNKS, TNKS2, XDH 2.21523
[BP] GO:0007154 None ADORA1, ADRA2C, BCL2, DRD1, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 2.20845
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALPL, BCL2, CA2, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRA, F3, FABP3, FABP4, GRIK5, GRM1, GRM5, HMGCR, HSD11B2, HSD17B2, NR1H4, PPARA, PTAFR, PTPN1, THRA, TYR 2.20757
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, HMGCR 2.2001
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5 2.2001
[BP] GO:0031644 None ADORA1, ADRA2C, GRM1, PTAFR 2.17981
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA2A, ADRA2C, BCL2, CA2, CDK6, CYP1B1, ESR1, ESRRA, ESRRB, F3, GRM1, HMGCR, NR1H4, PTAFR, SLC1A1, THRA, THRB, TNKS2, XDH 2.17299
[BP] GO:0032846 positive regulation of homeostatic process CA2, CA7, DRD1, NR1H4, TNKS, TNKS2 2.16872
[BP] GO:1900543 None ADRA2A, GRM3, GRM8, PPARA 2.16405
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.15854
[BP] GO:0035235 None GRIA2, GRIA4, GRIK5 2.15854
[BP] GO:0045980 None ADRA2A, GRM3, GRM8, PPARA 2.14643
[BP] GO:0042493 response to drug AKR1B1, BCL2, CDK6, CYP1A1, CYP1B1, DRD1, FABP3, HMGCR, HSD11B2, PTAFR 2.13665
[BP] GO:1900542 None ADRA2A, DRD1, ESRRB, GRM3, GRM8, PPARA 2.09765
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRA2A, ADRA2C, BCL2, CDC25B, CSNK2A1, CYP1B1, DRD1, ESR1, ESR2, F3, FABP4, GRM1, GRM3, GRM5, HMGCR, NR1H4, PPARA, PTAFR, PTPN1, TNKS, XDH 2.07429
[BP] GO:0035587 None ADORA1, ADORA3, PTAFR 2.07429
[BP] GO:0008209 androgen metabolic process CYP19A1, CYP3A4, ESR1 2.07429
[BP] GO:0051952 None ADORA1, ADRA2A, ADRA2C, DRD1 2.06866
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, FABP3, FABP4, FUT7, GBA2, XDH 2.06051
[BP] GO:0043696 None CDK6, ESRRB 2.05625
[BP] GO:0043697 None CDK6, ESRRB 2.05625
[BP] GO:0035624 None ADRA2A, ADRA2C 2.05625
[BP] GO:0060509 None THRA, THRB 2.05625
[BP] GO:0014060 None ADRA2A, ADRA2C 2.05625
[BP] GO:0006140 None ADRA2A, DRD1, ESRRB, GRM3, GRM8, PPARA 2.05482
[BP] GO:0019098 None DRD1, THRA, THRB 2.05119
[BP] GO:0007176 None ADORA1, ADRA2A, ADRA2C 2.05119
[BP] GO:0035265 organ growth BCL2, CYP19A1, ESR1 2.01015
[BP] GO:1901661 None AKR1B1, AKR1B10, HMGCR 2.01015
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.49896
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, GBA2, GRIA2, HMGCR, HSD11B1, HSD11B2, HSD17B2 3.17404
[CC] GO:0098590 plasma membrane region ADORA1, ADRA2A, CA2, CA4, DRD1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SLC1A1 2.93987
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ALPL, BCL2, CA12, CA14, CA2, CA4, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DRD1, ESR1, F3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD11B1, HSD11B2, HSD17B2, PTAFR, PTPN1, SLC1A1, TNKS, TNKS2, TYR 2.43678
[CC] GO:0097060 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 2.43013
[CC] GO:0044432 endoplasmic reticulum part BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, GBA2, GRIA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, PTPN1 2.43013
[CC] GO:0044456 None ACHE, ADORA1, ADRA2C, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 2.26658
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ALPL, BCL2, CA12, CA14, CA2, CA4, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, ESR1, F3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD11B1, HSD11B2, HSD17B2, PTAFR, PTPN1, SLC1A1, TYR 2.26031
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA2A, ADRA2C, CA4, DRD1, F3, GRIA2, GRM1, GRM3, GRM5, GRM8, PTAFR, SLC1A1 2.00171
[MF] GO:0046914 transition metal ion binding AOX1, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, NR1H4, PPARA, PTPN1, THRA, THRB, TNKS, TYR, XDH 9.80381
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.33933
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, NR1H4, PPARA, THRA, THRB 8.33933
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, NR1H4, PPARA, THRA, THRB 8.33933
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7 8.17591
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, NR1H4, PPARA, THRA, THRB 7.78278
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA2A, ADRA2C, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, NR1H4, PPARA, PTAFR, THRA, THRB 7.24053
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA2A, ADRA2C, CDK6, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, NR1H4, PPARA, PTAFR, THRA, THRB 6.92374
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, NR1H4 6.65331
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 6.50199
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 6.47029
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA2A, ADRA2C, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, NR1H4, PPARA, PTAFR, THRA, THRB 6.47029
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA2A, ADRA2C, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, NR1H4, PPARA, PTAFR, THRA, THRB 5.73577
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.30911
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.05008
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, ESR1, ESR2, ESRRA, ESRRB, NR1H4, PPARA, PTPN1, THRA, THRB, TNKS 5.05008
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7 5.01916
[MF] GO:0043167 ion binding ACHE, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA7, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, HMGCR, HSD17B1, NR1H4, PPARA, PTAFR, PTPN1, SLC1A1, THRA, THRB, TNKS, TNKS2, TYR, XDH 4.50249
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.48429
[MF] GO:0008289 lipid binding CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD11B2, HSD17B1, NR1H4, PPARA, PTAFR 4.40968
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7 4.39188
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, HMGCR, HSD11B2, HSD17B1, XDH 4.16268
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.09873
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TYR 3.86931
[MF] GO:0005506 iron ion binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, XDH 3.79091
[MF] GO:0004887 None NR1H4, THRA, THRB 3.6187
[MF] GO:0030594 None DRD1, GRIA2, GRIA4, GRIK5, GRM1, GRM5 3.59951
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.49021
[MF] GO:0043169 cation binding ACHE, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, ESR1, ESR2, ESRRA, ESRRB, FDPS, NR1H4, PPARA, PTPN1, SLC1A1, THRA, THRB, TNKS, TNKS2, TYR, XDH 3.47702
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.37534
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.29323
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, F3, FDPS, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PTPN1, TNKS, TNKS2, TYR, XDH 2.9464
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TYR 2.86976
[MF] GO:0046872 metal ion binding ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FDPS, NR1H4, PPARA, PTPN1, SLC1A1, THRA, THRB, TNKS, TNKS2, TYR, XDH 2.86343
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.81352
[MF] GO:0003845 None HSD11B1, HSD11B2 2.81352
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.79134
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRA2A, ADRA2C, DRD1, F3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, PTAFR 2.52836
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRA2A, ADRA2C, DRD1, F3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, PTAFR 2.52836
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.5159
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7 2.50762
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.43155
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.43155
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.43013
[MF] GO:0004938 None ADRA2A, ADRA2C 2.43013
[MF] GO:0099583 None GRM1, GRM5 2.43013
[MF] GO:1901338 None ADRA2A, ADRA2C, DRD1 2.41144
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.26502
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.2176
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.2176
[MF] GO:0004971 None GRIA2, GRIA4 2.2176
[MF] GO:0032795 None ADORA1, ADRA2A 2.2176
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.2176
[MF] GO:0035586 None ADORA1, ADORA3, PTAFR 2.19612
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.17271
[MF] GO:0051721 None BCL2, HMGCR, PTPN1 2.07429
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.05625
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.05625


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GRIA2, THRB, THRA, GRIK5, PTAFR, ADRA2C, GRM1, ADRA2A, GRM3, GRM5, ADORA3, GRM8, ADORA1, DRD1, GRIA4 12.6071
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 11.2994
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 7.3504
Metabolic pathways_Homo sapiens_hsa01100 FDPS, AKR1B1, HMGCR, TYR, CYP3A4, GBA2, CYP19A1, HSD11B1, FUT7, DAO, AKR1B10, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 6.6684
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA14 9.6183
Ovarian steroidogenesis_Homo sapiens_hsa04913 HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1 5.1504
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 4.3892
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 4.1215
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 4.1968
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1, CYP3A4 3.3214
Bile secretion_Homo sapiens_hsa04976 CA2, NR1H4, HMGCR, CYP3A4 3.2116
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, GRM1, GRIA4 2.6893
cAMP signaling pathway_Homo sapiens_hsa04024 GRIA2, ADORA1, DRD1, PPARA, GRIA4 2.5967
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, GRM8, GRM1 2.1963
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2, DRD1 2.4936
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, DRD1, GRIA4 2.1828
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1, ADRA2C, ADRA2A 2.0763
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 2.1828
Calcium signaling pathway_Homo sapiens_hsa04020 GRM5, PTAFR, DRD1, GRM1 1.997
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1, CYP3A4 2.1828
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, PPARA 2.1828
Estrogen signaling pathway_Homo sapiens_hsa04915 ESR1, GRM1, ESR2 1.8477
Gap junction_Homo sapiens_hsa04540 GRM5, DRD1, GRM1 1.9759
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 THRB, THRA, ESR1 1.7242
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.7172
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, DRD1, GRIA4 1.656
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, BCL2, CYP1B1, CDC25B 1.4495
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 BCL2, F3 1.0725
Prolactin signaling pathway_Homo sapiens_hsa04917 ESR1, ESR2 1.2792
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.4438
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 1.1286
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 1.1123
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2 1.0235
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1 1.4083
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2 1.1646
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1 1.2669
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 1.0295
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4115
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.1203
Peroxisome_Homo sapiens_hsa04146 DAO, XDH 1.1836
Hepatitis B_Homo sapiens_hsa05161 CDK6, BCL2 0.8444
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 0.8904
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2, BCL2 1.4988
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, AOX1 0.8072
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.9535
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.6629
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.7256
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.5735
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.6666
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8277
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP3A4 1.841
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7242
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, BCL2 0.4664
Pathways in cancer_Homo sapiens_hsa05200 CDK6, BCL2 0.409
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2711
HTLV-I infection_Homo sapiens_hsa05166 FDPS 0.2711
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7875
Apoptosis_Homo sapiens_hsa04210 BCL2 0.409
FoxO signaling pathway_Homo sapiens_hsa04068 GRM1 0.409
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3616
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B 0.4713
Parkinson's disease_Homo sapiens_hsa05012 DRD1 0.409
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.409
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.409
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3584
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.4253
Tight junction_Homo sapiens_hsa04530 CSNK2A1 0.409
AMPK signaling pathway_Homo sapiens_hsa04152 HMGCR 0.4179
Influenza A_Homo sapiens_hsa05164 FDPS 0.3584
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.3416
Focal adhesion_Homo sapiens_hsa04510 BCL2 0.3337
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6 0.3337
Proteoglycans in cancer_Homo sapiens_hsa05205 ESR1 0.3337
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4698
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3514
Prostate cancer_Homo sapiens_hsa05215 BCL2 0.4884
Alcoholism_Homo sapiens_hsa05034 DRD1 0.3584
Tuberculosis_Homo sapiens_hsa05152 BCL2 0.3584
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.396
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB 0.409
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.3988
Toxoplasmosis_Homo sapiens_hsa05145 BCL2 0.4267
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2 0.4674
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4698
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.409
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9901
Taste transduction_Homo sapiens_hsa04742 GRM1 0.5038
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4742
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4742
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4884
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.5375
Melanoma_Homo sapiens_hsa05218 CDK6 0.5426
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5375
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4884
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.5174
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5426
Glioma_Homo sapiens_hsa05214 CDK6 0.5544
Pancreatic cancer_Homo sapiens_hsa05212 CDK6 0.5542
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5546
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5426
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.5611
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6 0.5957
Staphylococcus aureus infection_Homo sapiens_hsa05150 PTAFR 0.5957
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 FDPS, HMGCR 1.997
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6409
Arginine and proline metabolism_Homo sapiens_hsa00330 DAO 0.6287
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6388
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6409
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2 0.6904
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 DAO 0.6868
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7781
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7989
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8225
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8142
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.0775
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.9535
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0295
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3065


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)