TCM Prescription: Tiao Jing Zhi Dai Pills



Prescription Description
Prescription IDTCMF5660
Pinyin NameTiao Jing Zhi Dai Wan
Chinese Name调经止带丸
English NameTiao Jing Zhi Dai Pills
Function Description带下病, 月经失调
IndicationsLeukorrhea disorder, Irregular menstruation
Disease ICD-11 Category SC20 [Leukorrhea disorder (TM1), 带下病 (TM1) ];
GA20.3 [Abnormal regularity of uterine bleeding, 子宫出血周期异常 ];
Human Tissues Associated with IndicationUterus
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1966 Rehmannia glutinosa 熟地黄 TCMH1966 ITSAH4578-14
TCMH2265 Cyperus rotundus 香附 TCMH2265 GENG1049-15
TCMH2554 Polygala tenuifolia 远志 TCMH2554 MF096619
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH789 Lonicera japonica 海螵蛸 TCMH789 ITSAI3881-14
TCMH259 Halloysitum rubrum 赤石脂 TCMH259
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH316 Ailanthi cortex 椿皮 TCMH316
TCMH1525 Crassostrea gigas 牡蛎 TCMH1525 BCMOL364-12
TCMH949 Phellodendron amurense 黄柏 TCMH949 ITSAM1586-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT907 FDPS Farnesyl diphosphate synthase Lyase P14324


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1305 Salmonella enteritidis
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1385 Candida shehatae
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1448 Enterobacter aerogenes
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9 11.1938
[BP] GO:0044281 small molecule metabolic process AKR1B1, ALOX5, CA1, CA12, CA2, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FABP3, FDPS, FUT7, HMGCR, PIM1, PPARA, TYR, XDH 10.4464
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA5A, CA5B, CA6, CA7, CA9 10.2318
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD2, FABP3, FABP4, FDPS, FUT7, HMGCR, HSD17B2, MET, PPARA 8.54963
[BP] GO:0019748 secondary metabolic process AKR1B1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 7.24698
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9, DRD2, FABP3, PPARA 6.51664
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, ALOX5, AURKB, AXL, CA1, CA12, CA2, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, F10, F3, FABP3, FABP4, FDPS, FLT3, FUT7, HMGCR, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, RORC, SRC, TYR, XDH 6.48755
[BP] GO:0008202 steroid metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FDPS, HMGCR, HSD17B2 6.41815
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AXL, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, FABP3, HMGCR, HSD17B2, IGF1R, MMP2, MMP9, PPARA, RORC, SRC, TYR 6.35059
[BP] GO:0044255 cellular lipid metabolic process ACHE, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD2, FABP3, FABP4, FDPS, FUT7, HMGCR, MET, PPARA 6.30462
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, F10, F3, FABP3, FABP4, FLT3, HCAR2, HMGCR, HSD17B2, KDR, MET, PPARA, SRC, XDH 6.18373
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.95489
[BP] GO:0010033 response to organic substance AKR1B1, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, FABP3, FABP4, FLT3, HMGCR, HSD17B2, IGF1R, KDR, MMP2, PPARA, RORC, SRC, TYR 5.89463
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AXL, CA2, CA7, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, FLT3, HCAR2, HMGCR, KDR, MET, MMP9, SRC, XDH 5.63775
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AXL, CA2, CA7, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, FLT3, HCAR2, HMGCR, KDR, MET, MMP9, SRC, XDH 5.62188
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9, DRD2, FABP3, PPARA 5.48649
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, ALOX5, AURKB, AXL, CA1, CA12, CA2, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, F10, FABP3, FABP4, FDPS, FLT3, FUT7, HMGCR, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, PIM1, PPARA, RORC, SRC, TYR, XDH 5.31473
[BP] GO:0010035 response to inorganic substance AKR1B1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, KDR, MMP9, SRC 5.17522
[BP] GO:0042221 response to chemical AKR1B1, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, FABP3, FABP4, FLT3, HMGCR, HSD17B2, IGF1R, KDR, MMP2, MMP9, PPARA, RORC, SRC, TYR 5.10177
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FDPS, FLT3, HCAR2, HMGCR, PPARA, RORC, SRC 5.10177
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, IGF1R, KDR, MET, MMP9, SRC 4.87066
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, HCAR2, HMGCR, HSD17B2 4.82436
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, FDPS, HMGCR, TYR 4.63502
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, IGF1R, KDR, MET, MMP9, SRC 4.59621
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 4.22891
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, IGF1R, KDR, MET, MMP9, SRC 4.216
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CYP1B1, F3, FLT3, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PPARA, SRC, XDH 4.216
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, IGF1R, KDR, MET, MMP9, SRC 4.216
[BP] GO:0055114 oxidation-reduction process AKR1B1, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HMGCR, HSD17B2, TYR, XDH 4.21357
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, DRD1, DRD2, HCAR2, HMGCR, KDR, SRC 4.1429
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 4.10143
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 4.09737
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, F10, F3, FABP3, FLT3, HCAR2, HMGCR, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, RORC, SRC, XDH 4.03604
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD17B2 4.03604
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, ALOX5, AXL, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, F10, F3, FABP4, HMGCR, HSD17B2, IGF1R, MET, MMP1, MMP2, MMP9, PIM1, PPARA, RORC, SRC, TYR 4.02651
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CYP1B1, F3, FLT3, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, SRC, XDH 3.95539
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD17B2 3.95539
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, RORC 3.92658
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AXL, CYP1B1, DRD2, F10, F3, FLT3, HMGCR, KDR, MET, SRC, XDH 3.86893
[BP] GO:0009636 response to toxic substance AKR1B1, AXL, CYP1A1, CYP1B1, DRD1, DRD2, HMGCR, KDR, SRC 3.80487
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.80347
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.80347
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA 3.76736
[BP] GO:0006720 isoprenoid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP3A4, FDPS, HMGCR 3.73799
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, FDPS, HMGCR, HSD17B2 3.72403
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, DRD1, DRD2, KDR, SRC 3.67975
[BP] GO:0009056 catabolic process ACHE, ADORA1, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, FUT7, MMP1, MMP2, MMP9, SRC, XDH 3.6793
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, F10, F3, MET, SRC, XDH 3.65036
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, CYP1B1, DRD2, F3, FABP3, FLT3, HMGCR, IGF1R, KDR, MMP2, MMP9, PIM1, SRC, XDH 3.6218
[BP] GO:0033993 response to lipid AXL, CA2, CA9, CYP1A1, CYP1A2, FABP3, FLT3, HSD17B2, RORC, SRC, TYR 3.55379
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, F10, F3, FABP3, FABP4, FLT3, HCAR2, HMGCR, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, RORC, SRC, XDH 3.55379
[BP] GO:0014070 response to organic cyclic compound CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, FLT3, RORC, SRC, TYR 3.53486
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, DRD2 3.52072
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, AXL, CA2, CA7, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PPARA, SRC 3.49952
[BP] GO:0042493 response to drug AKR1B1, AXL, CA9, CYP1A1, CYP1B1, DRD1, DRD2, FABP3, HMGCR, KDR, SRC 3.49933
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, CA2, CA6, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, F10, F3, FABP3, FABP4, FLT3, HMGCR, HSD17B2, IGF1R, KDR, MMP2, MMP9, PPARA, RORC, SRC, TYR 3.43915
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CYP1B1, F3, FLT3, HCAR2, HMGCR, IGF1R, KDR, MMP9, PIM1, SRC, XDH 3.37838
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.37675
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, FABP4, FLT3, FUT7, HMGCR, HSD17B2, KDR, MET, MMP2, MMP9, PIM1, PPARA, RORC, SRC, TYR 3.31563
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 3.2942
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PPARA, SRC 3.28106
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, CYP19A1, CYP3A4, FDPS, HMGCR, TYR 3.19288
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP3A4 3.1404
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AURKB, AXL, CYP1B1, DRD2, F10, F3, FLT3, HMGCR, IGF1R, KDR, MET, MMP9, SRC, XDH 3.10123
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, FLT3, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, SRC, XDH 3.08638
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, CA2, CYP1A1, DRD1, DRD2, HMGCR, MMP2, PPARA, SRC, TYR 3.06666
[BP] GO:0016042 lipid catabolic process ADORA1, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 3.05036
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, FLT3, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, SRC, XDH 3.01132
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, DRD1, DRD2 3.00223
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 3.00223
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.89463
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, SRC 2.89463
[BP] GO:0006721 terpenoid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP3A4, FDPS 2.88017
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.87151
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.86897
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, AXL, CYP1A1, CYP1A2, CYP1B1, DRD1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, RORC, SRC 2.80288
[BP] GO:0046777 protein autophosphorylation AURKB, FLT3, IGF1R, KDR, PIM1, SRC 2.79375
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AXL, CYP1B1, DRD2, F10, F3, FLT3, HMGCR, KDR, MET, MMP9, SRC, XDH 2.71609
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, FABP3, PPARA 2.71609
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, MET 2.70183
[BP] GO:0030335 positive regulation of cell migration DRD1, F10, F3, IGF1R, KDR, MET, MMP9, SRC 2.6893
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, CA2, CA7, DRD1, DRD2 2.65679
[BP] GO:0010243 response to organonitrogen compound AKR1B1, DRD1, DRD2, FABP3, FLT3, IGF1R, MMP2, PPARA, SRC, TYR 2.63
[BP] GO:2000147 positive regulation of cell motility DRD1, F10, F3, IGF1R, KDR, MET, MMP9, SRC 2.58929
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD17B2 2.54982
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, AXL, CA12, CA2, CA7, DRD1, DRD2, FABP3, FABP4, FLT3, MET, SRC 2.54084
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, F3, FABP4, HMGCR, KDR, MET, PPARA 2.53345
[BP] GO:0051272 positive regulation of cellular component movement DRD1, F10, F3, IGF1R, KDR, MET, MMP9, SRC 2.51693
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CYP1B1, DRD2, FABP4, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, SRC 2.50887
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, HCAR2 2.50173
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.50173
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2 2.50022
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA 2.48995
[BP] GO:0009719 response to endogenous stimulus AKR1B1, CA2, CA9, CYP1A2, DRD1, FABP3, FLT3, IGF1R, MMP2, PPARA, SRC 2.48337
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CYP19A1, CYP1A1, CYP1A2, FLT3, HSD17B2, KDR, PPARA, SRC, TYR 2.46055
[BP] GO:0040017 positive regulation of locomotion DRD1, F10, F3, IGF1R, KDR, MET, MMP9, SRC 2.44245
[BP] GO:1901698 response to nitrogen compound AKR1B1, DRD1, DRD2, FABP3, FLT3, IGF1R, MMP2, PPARA, SRC, TYR 2.40209
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.40209
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, SRC 2.385
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, ALOX5, AURKB, AXL, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, F10, F3, FABP3, FABP4, FDPS, FLT3, FUT7, HMGCR, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, RORC, SRC, TYR, XDH 2.385
[BP] GO:0071310 cellular response to organic substance AKR1B1, AXL, CYP1A1, CYP1B1, DRD1, FABP4, FLT3, IGF1R, KDR, MMP2, RORC, SRC 2.37554
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, AXL, CA2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, FLT3, HSD17B2, KDR, MMP9, PIM1, PPARA, RORC, SRC, TYR 2.37554
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B2 2.36814
[BP] GO:0008299 None CYP1A1, FDPS, HMGCR 2.36814
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.36814
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AXL, CYP1B1, DRD2, F10, F3, FABP4, FLT3, HMGCR, KDR, MET, MMP2, MMP9, SRC, XDH 2.29006
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, HMGCR, IGF1R, KDR, MMP9, PIM1, SRC 2.28278
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, F10, F3, MET, SRC 2.27988
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.27988
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PIM1, PPARA, TYR 2.27988
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.27988
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.27988
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9 2.27988
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, DRD2, MMP2, PPARA, SRC 2.2535
[BP] GO:0018958 None AKR1B1, DRD1, DRD2, TYR 2.24139
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, DRD2, F3, FLT3, HMGCR, IGF1R, KDR, MMP2, MMP9, PIM1 2.18968
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, DRD2, MMP2, PPARA, SRC 2.1887
[BP] GO:0050878 regulation of body fluid levels ADORA1, AKR1B1, DRD2, F10, F3, MET, XDH 2.15959
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP3A4, FDPS, HMGCR, HSD17B2 2.13842
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, HMGCR, PPARA 2.1011
[BP] GO:0021853 None DRD1, DRD2 2.1011
[BP] GO:0010641 None F3, SRC 2.1011
[BP] GO:0007598 None F10, F3 2.1011
[BP] GO:1904936 None DRD1, DRD2 2.1011
[BP] GO:0042321 None ADORA1, DRD2 2.1011
[BP] GO:0001659 None ADORA1, DRD1, DRD2 2.1011
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, DRD1, KDR, SRC 2.09417
[BP] GO:1901575 None ACHE, ADORA1, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, FUT7, XDH 2.0929
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.07855
[BP] GO:0046165 None AKR1B1, CYP3A4, FDPS, HMGCR 2.07221
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, DRD2, MMP2, PPARA, SRC 2.03383
[BP] GO:0009611 response to wounding ACHE, ADORA3, CYP1A1, DRD2, PPARA 2.02808
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CYP1B1, DRD1, IGF1R, MMP2, MMP9, RORC, SRC 2.0276
[CC] GO:0044432 endoplasmic reticulum part CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, F10, FLT3, HMGCR, HSD17B2 2.18087
[CC] GO:0005789 endoplasmic reticulum membrane CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, HMGCR, HSD17B2 2.09417
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX5, AXL, CA12, CA14, CA2, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, F10, F3, FLT3, FUT7, HCAR2, HMGCR, HSD17B2, IGF1R, KDR, MET, MMP2, PIM1, SRC, TYR 1.79864
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, AXL, CA12, CA14, CA2, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, F10, F3, FLT3, FUT7, HCAR2, HMGCR, HSD17B2, IGF1R, KDR, MET, SRC, TYR 1.77173
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, AXL, DRD1, DRD2, F10, F3, FLT3, IGF1R, KDR, MET 1.3355
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9 15.8456
[MF] GO:0046914 transition metal ion binding ALOX5, CA1, CA12, CA2, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, MMP1, MMP2, MMP9, PIM1, PPARA, RORC, TYR, XDH 13.5434
[MF] GO:0043167 ion binding ACHE, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, F10, F3, FABP3, FABP4, FDPS, FLT3, HMGCR, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, RORC, SRC, TYR, XDH 10.6427
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9 10.4714
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9 9.39532
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, F10, F3, FDPS, FLT3, FUT7, HMGCR, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, SRC, TYR, XDH 9.38862
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 9.35885
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 7.57751
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, TYR 6.97501
[MF] GO:0043169 cation binding ACHE, ALOX5, AURKB, CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, F10, FDPS, MMP1, MMP2, MMP9, PIM1, PPARA, RORC, TYR, XDH 6.83247
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, XDH 6.68316
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9 6.28056
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, SRC 6.16442
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 6.00687
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, SRC 5.95489
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, TYR 5.61457
[MF] GO:0016491 oxidoreductase activity AKR1B1, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HMGCR, HSD17B2, TYR, XDH 5.11357
[MF] GO:0046872 metal ion binding ALOX5, AURKB, CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, F10, FDPS, MMP1, MMP2, MMP9, PIM1, PPARA, RORC, TYR, XDH 5.10177
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP3A4 4.99588
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA5A, CA5B, CA6, CA7, CA9, MMP1, MMP2, MMP9, PPARA, RORC 4.64078
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, DRD1, DRD2, FLT3, IGF1R, KDR, MET, PIM1, PPARA, SRC 4.63835
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HMGCR, SRC, XDH 4.09737
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.85273
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.49952
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.43915
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.95738
[MF] GO:0008389 None CYP2A13, CYP2A6 2.89463
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, DRD1, DRD2, F3, FLT3, HCAR2, IGF1R, KDR, MET, PPARA, RORC 2.50887
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.50173
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.27988
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.27988
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.1011
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, DRD1, DRD2, F3, FLT3, HCAR2, IGF1R, KDR, MET, PPARA, RORC 2.09417
[MF] GO:0017171 serine hydrolase activity ACHE, F10, F3, MMP1, MMP2, MMP9 2.0929


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA7, CA6, CA9, CA14 17.5854
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.0019
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 6.7781
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 6.2906
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 6.0812
Metabolic pathways_Homo sapiens_hsa01100 FDPS, AKR1B1, HMGCR, TYR, CYP3A4, CYP19A1, CYP2A6, FUT7, ALOX5, HSD17B2, CYP1A2, CYP1A1, XDH 4.2965
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, IGF1R 4.018
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.3905
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, CYP3A4 3.7383
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, ADORA1, DRD1, DRD2, PPARA 3.0243
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.6763
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, DRD2, MET, IGF1R 2.9718
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, MMP9, MET, IGF1R 2.6527
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 3.0114
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH 2.8914
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2, CYP3A4 2.4241
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.3292
Adherens junction_Homo sapiens_hsa04520 SRC, MET, IGF1R 2.3835
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, IGF1R 2.2043
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR, CYP3A4 2.4126
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1, F3 2.1119
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9 2.1191
Gap junction_Homo sapiens_hsa04540 SRC, DRD1, DRD2 2.2098
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.8817
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, ADORA1, DRD1, DRD2 1.7934
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET 1.7016
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.6453
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.332
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.5569
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.5123
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.5558
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.4473
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.4237
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.1884
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.2761
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.4473
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.3589
Cocaine addiction_Homo sapiens_hsa05030 DRD1, DRD2 1.6552
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 1.2761
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 KDR, MET, IGF1R 0.9763
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.3589
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 1.084
Dopaminergic synapse_Homo sapiens_hsa04728 DRD1, DRD2 1.046
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.0874
AMPK signaling pathway_Homo sapiens_hsa04152 HMGCR, IGF1R 1.0677
Hepatitis B_Homo sapiens_hsa05161 SRC, MMP9 0.9763
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.9801
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.8931
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.8652
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP3A4 2.042
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.5724
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 IGF1R 0.5656
HTLV-I infection_Homo sapiens_hsa05166 FDPS 0.3399
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5656
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5656
Prostate cancer_Homo sapiens_hsa05215 IGF1R 0.5724
Insulin resistance_Homo sapiens_hsa04931 PPARA 0.5487
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.5487
Melanogenesis_Homo sapiens_hsa04916 TYR 0.564
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5724
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.3971
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.5487
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.4076
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.5615
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.564
Purine metabolism_Homo sapiens_hsa00230 XDH 0.4445
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.4744
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5724
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.4823
Platelet activation_Homo sapiens_hsa04611 SRC 0.5318
Influenza A_Homo sapiens_hsa05164 FDPS 0.4445
Calcium signaling pathway_Homo sapiens_hsa04020 DRD1 0.4445
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5656
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5724
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.6375
Tuberculosis_Homo sapiens_hsa05152 SRC 0.4445
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 IGF1R 0.5005
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.516
Tight junction_Homo sapiens_hsa04530 SRC 0.504
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.4744
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5656
Glioma_Homo sapiens_hsa05214 IGF1R 0.6375
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.6207
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.5382
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6375
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.5318
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.516
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.6156
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.4352
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5 0.5487
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.5382
Axon guidance_Homo sapiens_hsa04360 MET 0.5243
Peroxisome_Homo sapiens_hsa04146 XDH 0.5761
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6375
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.6375
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.626
Amphetamine addiction_Homo sapiens_hsa05031 DRD1 0.6375
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B1 0.6375
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.6375
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5 0.6375
Shigellosis_Homo sapiens_hsa05131 SRC 0.6375
Malaria_Homo sapiens_hsa05144 MET 0.6985
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 FDPS, HMGCR 2.2098
Galactose metabolism_Homo sapiens_hsa00052 AKR1B1 0.8652
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.8233
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8592
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B1 0.819
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B1 0.8533
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8931
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8652
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2 0.9278
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8857


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)