Prescription Description
| Prescription ID | TCMF562 |
| Pinyin Name | Chang Wei Ning Pian |
| Chinese Name | 肠胃宁片 |
| English Name | Chang Wei Ning Tablet |
| Function Description | 腹泻, 腹胀, 腹痛, 胃脘痛 |
| Indications | Stomach ache disorder, Abdominal pain disorder, Diarrhea, Gastritis |
| Disease ICD-11 Category |
SA51 [Stomach ache disorder (TM1), 胃脘痛 (TM1)
]; SA58 [Abdominal pain disorder (TM1), 腹痛 (TM1) ]; ME05.1 [Diarrhoea, 腹泻 ]; DA42 [Gastritis, 胃炎 ]; |
| Human Tissues Associated with Indication | Intestine, Stomach |
| Reference | Chinese pharmacopoeia (2015) |
| Reference Book/link | ISBN 978-7-5067-7337-9 |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH426 | Codonopsis pilosula | 党参 | TCMH426 | ITSAL4530-14 |
| TCMH981 | Astragalus membranaceus | 黄芪 | TCMH981 | ITSAK2981-14 |
| TCMH1067 | Glycine max | 姜炭 | TCMH1067 | ITSAJ4675-14 |
| TCMH1803 | Amomum villosum | 砂仁 | TCMH1803 | ITSAD521-14 |
| TCMH677 | Pueraria lobata | 葛根 | TCMH677 | ITSAJ4206-14 |
| TCMH120 | Atractylodes macrocephala | 白术 | TCMH120 | ITSAN4430-14 |
| TCMH259 | Halloysitum rubrum | 赤石脂 | TCMH259 | |
| TCMH1533 | Saussurea lappa | 木香 | TCMH1533 | |
| TCMH193 | Psoralea corylifolia | 补骨脂 | TCMH193 | |
| TCMH562 | Saposhnikovia divaricata | 防风 | TCMH562 | ITSAE3225-14 |
| TCMH104 | Paeonia lactiflora | 白芍 | TCMH104 | ITSAH2416-14 |
| TCMH2376 | Corydalis yanhusuo | 延胡索 | TCMH2376 | |
| TCMH421 | Angelica sinensis | 当归 | TCMH421 | ITSAF173-14 |
| TCMH547 | Catechu | 儿茶 | TCMH547 | |
| TCMH2515 | Papaver somniferum | 罂粟壳 | TCMH2515 | ITSAD207-14 |
| TCMH628 | Glycyrrhiza uralensis | 甘草 | TCMH628 | ITSAM892-14 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT100 | TTR | Transthyretin | Unclassified | P02766 |
| TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
| TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
| TCMT113 | OPRD1 | Delta opioid receptor | GPCR | P41143 |
| TCMT116 | OPRM1 | Mu opioid receptor | GPCR | P35372 |
| TCMT117 | OPRK1 | Kappa opioid receptor | GPCR | P41145 |
| TCMT127 | PARP1 | Poly [ADP-ribose] polymerase-1 | Transferase | P09874 |
| TCMT128 | TNKS2 | Tankyrase-2 | Transferase | Q9H2K2 |
| TCMT129 | TNKS | Tankyrase-1 | Transferase | O95271 |
| TCMT13 | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | Lyase | P27695 |
Showing 1 to 10 of 138 entries
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1170 | Enterobacter cloacae |
| TCMT1175 | Human immunodeficiency virus |
| TCMT1176 | Streptococcus pneumoniae |
| TCMT1178 | Actinomyces viscosus |
| TCMT1179 | Escherichia coli ATCC 8739 |
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
| TCMT1182 | Streptococcus sanguinis |
| TCMT1186 | Plasmodium yoelii yoelii |
| TCMT1189 | Pseudomonas fluorescens |
| TCMT1190 | Plasmodium falciparum (isolate FcB1 / Columbia) |
Showing 1 to 10 of 69 entries
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|---|
| [BP] GO:0000302 | response to reactive oxygen species | AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC | 3.73061 |
| [BP] GO:0001101 | response to acid chemical | AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PPARG, SRC | 2.14096 |
| [BP] GO:0001503 | ossification | ALPL, BCL2, EGFR, MMP2, MMP9, TEK | 2.92583 |
| [BP] GO:0001505 | regulation of neurotransmitter levels | ACHE, CYP1B1, DRD1, DRD2, DRD3, EGFR, HSP90AA1, HSP90AB1, HTR1A, INSR, SMAD3 | 5.13574 |
| [BP] GO:0001659 | None | ADORA1, DRD1, DRD2, HTR2A | 3.03631 |
| [BP] GO:0001666 | response to hypoxia | ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, OPRD1, PPARA, SMAD3, SRC, TEK | 5.07384 |
| [BP] GO:0001676 | long-chain fatty acid metabolic process | CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 | 3.18489 |
| [BP] GO:0001932 | regulation of protein phosphorylation | ADORA1, ADRA1A, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, F2, FABP4, FLT3, HSP90AB1, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP9, OPRD1, OPRK1, OPRM1, PTPN1, SRC, TEK, XDH | 5.76065 |
| [BP] GO:0001934 | positive regulation of protein phosphorylation | ADORA1, ADRA1A, BCL2, CDC25B, DRD2, EGFR, F2, FLT3, HSP90AB1, HTR2A, HTR2B, INSR, KDR, MMP9, OPRD1, OPRK1, OPRM1, PTPN1, SRC, TEK, XDH | 5.95443 |
| [BP] GO:0001936 | None | F3, HTR2B, KDR, PPARG, TEK, XDH | 2.61173 |
Showing 1 to 10 of 666 entries
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|
| Acute myeloid leukemia_Homo sapiens_hsa05221 | FLT3, PIM1 | 1.1703 |
| Adherens junction_Homo sapiens_hsa04520 | PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R | 7.1905 |
| Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.4556 |
| Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | BCL2, ADRA1A | 0.6312 |
| AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | SMAD3, MMP2, BCL2, PIM1, F3 | 3.1287 |
| Alcoholism_Homo sapiens_hsa05034 | DRD1, DRD2 | 0.5436 |
| Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | HSD11B2, INSR | 1.3991 |
| Amphetamine addiction_Homo sapiens_hsa05031 | DRD1 | 0.465 |
| AMPK signaling pathway_Homo sapiens_hsa04152 | INSR, PPARG, ADRA1A, IGF1R | 1.9104 |
| Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | BCL2 | 0.536 |
Showing 1 to 10 of 159 entries
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples