Prescription ID | TCMF5506 |
Pinyin Name | Wu Lin Wan |
Chinese Name | 五淋丸 |
English Name | Wu Lin Pills |
Function Description | 热淋 |
Indications | Heat stranguria disorder, Acute prostatitis, Chronic prostatitis, Salmonella pyelonephritis, Chronic pyelonephritis, Cystitis, Urethritis |
Disease ICD-11 Category |
SA91 [Heat stranguria disorder (TM1), 热淋 (TM1)
]; GA91.Y [Other specified inflammatory and other diseases of prostate, 其他特指的前列腺炎性疾病 ]; GA91.0 [Chronic prostatitis, 慢性前列腺炎 ]; GC2Z [Diseases of the urinary system, unspecified, 泌尿系统疾病,未特指的 ]; GB55.Z [Chronic tubulo-interstitial nephritis, unspecified, 慢性肾小管-间质肾炎,未特指的 ]; GC00 [Cystitis, 膀胱炎 ]; GC02.Y [Other specified urethritis and urethral syndrome, 其他特指的尿道炎和尿道综合征 ]; |
Human Tissues Associated with Indication | Bladder |
Reference | CFDA |
Reference Book/link | http://samr.cfda.gov.cn/WS01/CL0001/ |
Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
---|---|---|---|---|
TCMH780 | Lygodium japonicum | 海金砂 | TCMH780 | ITSAJ4232-14 |
TCMH718 | Aristolochia manshuriensis | 关木通 | TCMH718 | GBVE2055-11 |
TCMH2641 | Gardenia jasminoides | 栀子 | TCMH2641 | ITSAJ4473-14 |
TCMH972 | Coptis chinensis | 黄连 | TCMH972 | ITSAO4469-14 |
TCMH1953 | Pyrrosia lingua | 石韦 | TCMH1953 | GBVQ3369-13 |
TCMH606 | Wolfiporia cocos | 茯苓 | TCMH606 | GBPOL314-13 |
TCMH916 | Succinus | 琥珀 | TCMH916 | |
TCMH451 | Rehmannia glutinosa | 地黄 | TCMH451 | ITSAH4578-14 |
TCMH104 | Paeonia lactiflora | 白芍 | TCMH104 | ITSAH2416-14 |
TCMH305 | Cnidium officinale | 川芎 | TCMH305 | ITSAP4207-14 |
TCMH421 | Angelica sinensis | 当归 | TCMH421 | ITSAF173-14 |
TCMH628 | Glycyrrhiza uralensis | 甘草 | TCMH628 | ITSAM892-14 |
Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
---|---|---|---|---|
TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
TCMT126 | TERT | Telomerase reverse transcriptase | Transferase | O14746 |
TCMT127 | PARP1 | Poly [ADP-ribose] polymerase-1 | Transferase | P09874 |
TCMT128 | TNKS2 | Tankyrase-2 | Transferase | Q9H2K2 |
TCMT129 | TNKS | Tankyrase-1 | Transferase | O95271 |
TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
TCMT131 | ACHE | Acetylcholinesterase | Hydrolase | P22303 |
TCMT133 | CA1 | Carbonic anhydrase I | Lyase | P00915 |
TCMT134 | CA2 | Carbonic anhydrase II | Lyase | P00918 |
TCMT135 | CA14 | Carbonic anhydrase XIV | Lyase | Q9ULX7 |
TCMT136 | CA12 | Carbonic anhydrase XII | Lyase | O43570 |
TCMT137 | CA9 | Carbonic anhydrase IX | Lyase | Q16790 |
TCMT138 | CA7 | Carbonic anhydrase VII | Lyase | P43166 |
TCMT139 | CA6 | Carbonic anhydrase VI | Lyase | P23280 |
TCMT140 | CA5B | Carbonic anhydrase VB | Lyase | Q9Y2D0 |
TCMT141 | CA5A | Carbonic anhydrase VA | Lyase | P35218 |
TCMT142 | CA4 | Carbonic anhydrase IV | Lyase | P22748 |
TCMT156 | CYP19A1 | Cytochrome P450 19A1 | Oxidoreductase | P11511 |
TCMT159 | TYR | Tyrosinase | Oxidoreductase | P14679 |
TCMT161 | HCAR2 | Hydroxycarboxylic acid receptor 2 | GPCR | Q8TDS4 |
TCMT162 | UGT1A1 | UDP-glucuronosyltransferase 1-1 | Transferase | P22309 |
TCMT174 | HSD11B1 | 11-beta-hydroxysteroid dehydrogenase 1 | Oxidoreductase | P28845 |
TCMT190 | PTPN2 | T-cell protein-tyrosine phosphatase | Hydrolase | P17706 |
TCMT2 | MAPT | Microtubule-associated protein tau | Unclassified | P10636 |
TCMT206 | CYP2A6 | Cytochrome P450 2A6 | Oxidoreductase | P11509 |
TCMT207 | BACE1 | Beta-secretase 1 | Protease | P56817 |
TCMT209 | HSD11B2 | 11-beta-hydroxysteroid dehydrogenase 2 | Oxidoreductase | P80365 |
TCMT212 | SRC | Tyrosine-protein kinase SRC | Kinase | P12931 |
TCMT215 | CYP1A1 | Cytochrome P450 1A1 | Oxidoreductase | P04798 |
TCMT217 | CYP2C8 | Cytochrome P450 2C8 | Oxidoreductase | P10632 |
TCMT219 | CYP1A2 | Cytochrome P450 1A2 | Oxidoreductase | P05177 |
TCMT223 | AKR1B1 | Aldose reductase | Oxidoreductase | P15121 |
TCMT23 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | Hydrolase | P05186 |
TCMT231 | GBA2 | Beta-glucosidase | Hydrolase | Q9HCG7 |
TCMT232 | ABCB1 | P-glycoprotein 1 | Transporter | P08183 |
TCMT236 | ESR2 | Estrogen receptor beta | Nuclear receptor | Q92731 |
TCMT239 | PIM1 | Serine/threonine-protein kinase PIM1 | Kinase | P11309 |
TCMT249 | CDK6 | Cyclin-dependent kinase 6 | Kinase | Q00534 |
TCMT257 | CYP1B1 | Cytochrome P450 1B1 | Oxidoreductase | Q16678 |
TCMT260 | FLT3 | Tyrosine-protein kinase receptor FLT3 | Kinase | P36888 |
TCMT261 | DAPK1 | Death-associated protein kinase 1 | Kinase | P53355 |
TCMT268 | CYP2A13 | Cytochrome P450 2A13 | Oxidoreductase | Q16696 |
TCMT27 | DRD1 | Dopamine D1 receptor | GPCR | P21728 |
TCMT280 | AKR1B10 | Aldo-keto reductase family 1 member B10 | Oxidoreductase | O60218 |
TCMT295 | MMP1 | Matrix metalloproteinase-1 | Hydrolase | P03956 |
TCMT296 | ADORA1 | Adenosine A1 receptor | GPCR | P30542 |
TCMT297 | FABP4 | Fatty acid binding protein adipocyte | Unclassified | P15090 |
TCMT298 | FABP3 | Fatty acid binding protein muscle | Hydrolase | P05413 |
TCMT304 | MMP14 | Matrix metalloproteinase 14 | Hydrolase | P50281 |
TCMT306 | MMP2 | Matrix metalloproteinase-2 | Hydrolase | P08253 |
TCMT321 | MMP9 | Matrix metalloproteinase 9 | Hydrolase | P14780 |
TCMT322 | MMP13 | Matrix metalloproteinase 13 | Hydrolase | P45452 |
TCMT33 | CYP3A4 | Cytochrome P450 3A4 | Oxidoreductase | P08684 |
TCMT332 | AOC3 | Amine oxidase, copper containing | Oxidoreductase | Q16853 |
TCMT344 | AOX1 | Aldehyde oxidase | Oxidoreductase | Q06278 |
TCMT369 | IGF1R | Insulin-like growth factor I receptor | Kinase | P08069 |
TCMT370 | KDR | Vascular endothelial growth factor receptor 2 | Kinase | P35968 |
TCMT374 | AURKB | Serine/threonine-protein kinase Aurora-B | Kinase | Q96GD4 |
TCMT388 | AXL | Tyrosine-protein kinase receptor UFO | Kinase | P30530 |
TCMT401 | MET | Hepatocyte growth factor receptor | Kinase | P08581 |
TCMT422 | CAMK2B | CaM kinase II beta | Kinase | Q13554 |
TCMT445 | NEK2 | Serine/threonine-protein kinase NEK2 | Kinase | P51955 |
TCMT45 | APP | Beta amyloid A4 protein | Unclassified | P05067 |
TCMT46 | F3 | Coagulation factor III | Unclassified | P13726 |
TCMT462 | NEK6 | Serine/threonine-protein kinase NEK6 | Kinase | Q9HC98 |
TCMT47 | BCL2 | Apoptosis regulator Bcl-2 | Ion channel | P10415 |
TCMT479 | AKT1 | Serine/threonine-protein kinase AKT | Kinase | P31749 |
TCMT484 | PLK1 | Serine/threonine-protein kinase PLK1 | Kinase | P53350 |
TCMT506 | PTK2B | Protein tyrosine kinase 2 beta | Kinase | Q14289 |
TCMT510 | KIT | Stem cell growth factor receptor | Kinase | P10721 |
TCMT560 | F10 | Coagulation factor X | Unclassified | P00742 |
TCMT563 | CDC25B | Dual specificity phosphatase Cdc25B | Hydrolase | P30305 |
TCMT567 | DNMT1 | DNA (cytosine-5)-methyltransferase 1 | Transferase | P26358 |
TCMT591 | ESRRA | Estrogen-related receptor alpha | Nuclear receptor | P11474 |
TCMT592 | XDH | Xanthine dehydrogenase | Oxidoreductase | P47989 |
TCMT597 | SLC28A3 | Solute carrier family 28 member 3 | Transporter | Q9HAS3 |
TCMT614 | EGLN1 | Egl nine homolog 1 | Oxidoreductase | Q9GZT9 |
TCMT63 | PPARA | Peroxisome proliferator-activated receptor alpha | Nuclear receptor | Q07869 |
TCMT65 | HSD17B1 | Estradiol 17-beta-dehydrogenase 1 | Oxidoreductase | P14061 |
TCMT66 | HSD17B2 | Estradiol 17-beta-dehydrogenase 2 | Oxidoreductase | P37059 |
TCMT690 | HDAC3 | Histone deacetylase 3 | Hydrolase | O15379 |
TCMT709 | SLC28A2 | Sodium/nucleoside cotransporter 2 | Transporter | O43868 |
TCMT710 | SLC28A1 | Sodium/nucleoside cotransporter 1 | Transporter | O00337 |
TCMT751 | DYRK1A | Dual-specificity tyrosine-phosphorylation regulated kinase 1A | Kinase | Q13627 |
TCMT752 | CSNK2A1 | Casein kinase II alpha | Kinase | P68400 |
TCMT784 | AVPR2 | Vasopressin V2 receptor | GPCR | P30518 |
TCMT785 | CXCR1 | Interleukin-8 receptor A | GPCR | P25024 |
TCMT786 | CCR4 | C-C chemokine receptor type 4 | GPCR | P51679 |
TCMT791 | PKN1 | Protein kinase N1 | Kinase | Q16512 |
TCMT793 | PYGL | Liver glycogen phosphorylase | Transferase | P06737 |
TCMT808 | FABP5 | Fatty acid binding protein epidermal | Unclassified | Q01469 |
TCMT809 | FABP2 | Fatty acid binding protein intestinal | Unclassified | P12104 |
TCMT810 | TLR2 | Toll-like receptor 2 | Unclassified | O60603 |
TCMT82 | ESR1 | Estrogen receptor alpha | Nuclear receptor | P03372 |
TCMT822 | FUT7 | Alpha-(1,3)-fucosyltransferase 7 | Transferase | Q11130 |
TCMT910 | ESRRB | Estrogen-related receptor beta | Nuclear receptor | O95718 |
Target ID | Target Name |
---|---|
TCMT1170 | Enterobacter cloacae |
TCMT1175 | Human immunodeficiency virus |
TCMT1176 | Streptococcus pneumoniae |
TCMT1178 | Actinomyces viscosus |
TCMT1179 | Escherichia coli ATCC 8739 |
TCMT1181 | Mycobacterium tuberculosis H37Ra |
TCMT1186 | Plasmodium yoelii yoelii |
TCMT1189 | Pseudomonas fluorescens |
TCMT1190 | Plasmodium falciparum (isolate FcB1 / Columbia) |
TCMT1208 | Escherichia coli K12 |
TCMT1209 | Staphylococcus haemolyticus |
TCMT1210 | Streptococcus sobrinus |
TCMT1211 | Fusobacterium nucleatum |
TCMT1212 | Verticillium dahliae |
TCMT1214 | Enterococcus faecium |
TCMT1215 | Pseudomonas aeruginosa PAO1 |
TCMT1218 | Staphylococcus aureus |
TCMT1222 | Plasmodium falciparum D6 |
TCMT1223 | Staphylococcus epidermidis |
TCMT1224 | Proteus mirabilis |
TCMT1226 | Klebsiella pneumoniae |
TCMT1227 | Streptococcus |
TCMT1229 | Enterococcus faecalis |
TCMT1230 | Human herpesvirus 5 |
TCMT1232 | Pseudomonas aeruginosa |
TCMT1234 | Bacillus coagulans |
TCMT1235 | Clostridium sporogenes |
TCMT1236 | Mycobacterium bovis |
TCMT1237 | Mycobacterium kansasii |
TCMT1238 | Mycobacterium xenopi |
TCMT1239 | Mycobacterium marinum |
TCMT1243 | Aspergillus flavus |
TCMT1245 | Phytophthora cactorum |
TCMT1246 | Escherichia coli |
TCMT1248 | Hepatitis C virus |
TCMT1249 | Dengue virus 2 |
TCMT1251 | Candida albicans |
TCMT1253 | Penicillium chrysogenum |
TCMT1255 | Human immunodeficiency virus 1 |
TCMT1284 | Penicillium expansum |
TCMT1286 | Bacillus cereus |
TCMT1289 | Shigella dysenteriae |
TCMT1294 | Human parainfluenza virus 3 |
TCMT1296 | Influenza A virus H3N2 |
TCMT1305 | Salmonella enteritidis |
TCMT1318 | Human T-lymphotropic virus 1 |
TCMT1321 | Staphylococcus hominis |
TCMT1343 | Staphylococcus simulans |
TCMT1344 | Staphylococcus sciuri |
TCMT1346 | Helicobacter pylori |
TCMT1349 | Helicobacter pylori SS1 |
TCMT1353 | Plasmodium yoelii |
TCMT1361 | Neisseria meningitidis |
TCMT1370 | Prevotella melaninogenica |
TCMT1382 | Plasmodium falciparum (isolate K1 / Thailand) |
TCMT1385 | Candida shehatae |
TCMT1408 | Colletotrichum gloeosporioides |
TCMT1412 | Salmonella typhimurium |
TCMT1438 | Plasmodium falciparum |
TCMT1439 | Mycobacterium smegmatis |
TCMT1442 | Leishmania donovani |
TCMT1443 | Leishmania amazonensis |
TCMT1444 | Fusarium oxysporum |
TCMT1447 | Respiratory syncytial virus |
TCMT1448 | Enterobacter aerogenes |
TCMT1449 | Influenza A virus |
TCMT1450 | Plasmodium falciparum 3D7 |
TCMT1454 | Bacillus subtilis |
TCMT1455 | Mycobacterium tuberculosis H37Rv |
TCMT1457 | Leishmania major |
TCMT1458 | Filobasidiella neoformans |
TCMT1460 | Mycobacterium intracellulare |
TCMT1462 | Streptococcus mutans |
TCMT1463 | Mycobacterium tuberculosis |
TCMT1464 | Hepatitis B virus |
TCMT1465 | Entamoeba histolytica |
GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
---|---|---|---|
[BP] GO:0015701 | bicarbonate transport | CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 | 11.7743 |
[BP] GO:0008152 | metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DNMT1, DRD1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, TYR, XDH | 10.8835 |
[BP] GO:0006730 | one-carbon metabolic process | CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 | 10.8835 |
[BP] GO:0008202 | steroid metabolic process | AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 10.7129 |
[BP] GO:0006629 | lipid metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KIT, MET, PPARA | 10.3438 |
[BP] GO:0019748 | secondary metabolic process | AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR | 9.56844 |
[BP] GO:0044281 | small molecule metabolic process | AKR1B1, AKR1B10, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FABP3, FUT7, GBA2, PIM1, PPARA, TYR, XDH | 8.62931 |
[BP] GO:0044237 | cellular metabolic process | ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DNMT1, DRD1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GBA2, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP2, PIM1, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, TYR, XDH | 8.34604 |
[BP] GO:1901700 | response to oxygen-containing compound | AKR1B1, ALPL, APP, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, IGF1R, MMP2, MMP9, PPARA, SRC, TYR | 8.16226 |
[BP] GO:0065008 | regulation of biological quality | ABCB1, ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, ESR1, F10, F3, FABP3, FABP4, FLT3, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KDR, KIT, MET, PPARA, SRC, TERT, TNKS, TNKS2, XDH | 8.02261 |
[BP] GO:0042445 | hormone metabolic process | ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 7.27751 |
[BP] GO:0010033 | response to organic substance | AKR1B1, ALPL, APP, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KDR, KIT, MMP2, PPARA, SRC, TYR | 7.27751 |
[BP] GO:0042221 | response to chemical | ABCB1, AKR1B1, ALPL, APP, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KDR, KIT, MMP2, MMP9, PPARA, SRC, TERT, TYR | 7.27472 |
[BP] GO:0009719 | response to endogenous stimulus | AKR1B1, ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DNMT1, DRD1, ESR1, ESRRA, FABP3, FLT3, HSD11B2, IGF1R, KIT, MMP2, PPARA, SRC | 6.93769 |
[BP] GO:0010647 | positive regulation of cell communication | ADORA1, AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, F10, F3, FLT3, HCAR2, KDR, KIT, MET, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH | 6.85305 |
[BP] GO:0023056 | positive regulation of signaling | ADORA1, AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, F10, F3, FLT3, HCAR2, KDR, KIT, MET, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH | 6.83036 |
[BP] GO:0033993 | response to lipid | ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, SRC, TYR | 6.48518 |
[BP] GO:0010035 | response to inorganic substance | AKR1B1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, KIT, MMP9, SRC, TERT | 6.26872 |
[BP] GO:0042127 | regulation of cell proliferation | ADORA1, ADORA3, AKR1B1, APP, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, DNMT1, ESR1, ESRRA, F3, FABP3, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, PIM1, SRC, TERT, XDH | 6.23292 |
[BP] GO:0048522 | positive regulation of cellular process | ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DRD1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FLT3, HCAR2, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, XDH | 6.23292 |
[BP] GO:0042446 | hormone biosynthetic process | AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 5.91011 |
[BP] GO:0015711 | organic anion transport | ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA | 5.84255 |
[BP] GO:0044238 | primary metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DNMT1, DRD1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, TYR, XDH | 5.8075 |
[BP] GO:2000145 | regulation of cell motility | ADORA1, ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, F10, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT | 5.73644 |
[BP] GO:0048518 | positive regulation of biological process | ABCB1, ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DRD1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, HCAR2, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, XDH | 5.67532 |
[BP] GO:0014070 | response to organic cyclic compound | ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRA, FLT3, HSD11B2, SRC, TYR | 5.66311 |
[BP] GO:0034754 | cellular hormone metabolic process | AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 | 5.61982 |
[BP] GO:0009725 | response to hormone | AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, KIT, PPARA, SRC | 5.34961 |
[BP] GO:0019373 | epoxygenase P450 pathway | CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 5.31819 |
[BP] GO:0030334 | regulation of cell migration | ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, DRD1, F10, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT | 5.31819 |
[BP] GO:0040012 | regulation of locomotion | ADORA1, ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, F10, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT | 5.29572 |
[BP] GO:0051270 | regulation of cellular component movement | ADORA1, ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, F10, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT | 5.28351 |
[BP] GO:0055114 | oxidation-reduction process | AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH | 5.27834 |
[BP] GO:0071704 | organic substance metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DNMT1, DRD1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, TYR, XDH | 5.11881 |
[BP] GO:0048513 | animal organ development | ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, KIT, PPARA, SRC, TYR | 5.05502 |
[BP] GO:0032502 | developmental process | ACHE, ADORA1, AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DYRK1A, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD17B2, KDR, KIT, MET, MMP2, MMP9, PIM1, PPARA, SRC, TERT, TNKS2, TYR | 5.05502 |
[BP] GO:0006468 | protein phosphorylation | APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC, TNKS | 5.04402 |
[BP] GO:0010817 | regulation of hormone levels | ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 5.00396 |
[BP] GO:0070887 | cellular response to chemical stimulus | AKR1B1, ALPL, APP, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, SRC, TERT | 4.98385 |
[BP] GO:0010646 | regulation of cell communication | ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DYRK1A, ESR1, ESR2, F10, F3, FLT3, HCAR2, IGF1R, KDR, KIT, MET, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH | 4.97709 |
[BP] GO:0010941 | regulation of cell death | ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HCAR2, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, XDH | 4.97709 |
[BP] GO:0046777 | protein autophosphorylation | AURKB, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, PIM1, SRC | 4.94847 |
[BP] GO:0044255 | cellular lipid metabolic process | ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FABP3, FABP4, FUT7, GBA2, KIT, MET, PPARA | 4.92437 |
[BP] GO:0023051 | regulation of signaling | ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DYRK1A, ESR1, ESR2, F10, F3, FLT3, HCAR2, IGF1R, KDR, KIT, MET, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH | 4.88822 |
[BP] GO:0043067 | regulation of programmed cell death | ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HCAR2, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTPN1, SRC, TERT, XDH | 4.8662 |
[BP] GO:0030335 | positive regulation of cell migration | APP, BCL2, DRD1, F10, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT | 4.79932 |
[BP] GO:0006820 | anion transport | ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA | 4.73446 |
[BP] GO:2000147 | positive regulation of cell motility | APP, BCL2, DRD1, F10, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT | 4.64388 |
[BP] GO:0051272 | positive regulation of cellular component movement | APP, BCL2, DRD1, F10, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT | 4.53671 |
[BP] GO:0032844 | regulation of homeostatic process | ADORA1, AURKB, BCL2, CA2, CA7, CDK6, DRD1, HCAR2, KDR, SRC, TNKS, TNKS2 | 4.50291 |
[BP] GO:0040017 | positive regulation of locomotion | APP, BCL2, DRD1, F10, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT | 4.39368 |
[BP] GO:0048856 | anatomical structure development | ACHE, ADORA1, AKR1B1, ALPL, APP, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DYRK1A, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, KDR, KIT, MMP9, PIM1, PPARA, SRC, TYR | 4.38278 |
[BP] GO:0032847 | regulation of cellular pH reduction | BCL2, CA2, CA7 | 4.31344 |
[BP] GO:0071310 | cellular response to organic substance | AKR1B1, ALPL, APP, AXL, BCL2, CDK6, CYP1A1, CYP1B1, DNMT1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, SRC | 4.3114 |
[BP] GO:0060548 | negative regulation of cell death | ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TERT | 4.3114 |
[BP] GO:0009967 | positive regulation of signal transduction | ADORA1, AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, F10, F3, FLT3, KDR, KIT, MET, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH | 4.27899 |
[BP] GO:0009056 | catabolic process | ACHE, ADORA1, AKR1B10, AOX1, AURKB, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, FUT7, GBA2, MMP1, MMP2, MMP9, SRC, XDH | 4.25247 |
[BP] GO:1901615 | organic hydroxy compound metabolic process | AKR1B1, AKR1B10, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, GBA2, TYR | 4.22052 |
[BP] GO:0018108 | peptidyl-tyrosine phosphorylation | AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, SRC | 4.08365 |
[BP] GO:0006694 | steroid biosynthetic process | AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 4.08098 |
[BP] GO:0043069 | negative regulation of programmed cell death | ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTPN1, SRC, TERT | 4.0791 |
[BP] GO:0018212 | peptidyl-tyrosine modification | AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, SRC | 4.04573 |
[BP] GO:0008284 | positive regulation of cell proliferation | AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, ESR1, F3, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, PIM1, TERT | 3.99313 |
[BP] GO:0016310 | phosphorylation | APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC, TNKS | 3.97885 |
[BP] GO:0016042 | lipid catabolic process | ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, GBA2 | 3.94405 |
[BP] GO:0050896 | response to stimulus | ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA6, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, ESR1, ESRRA, F10, F3, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KDR, KIT, MMP2, MMP9, PPARA, PTPN1, SRC, TERT, TYR | 3.92561 |
[BP] GO:0032879 | regulation of localization | ABCB1, ACHE, ADORA1, ADORA3, APP, AXL, BCL2, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD1, F10, F3, HCAR2, IGF1R, KDR, KIT, MET, MMP9, PPARA, PTPN1, SRC, TERT | 3.91824 |
[BP] GO:0043393 | regulation of protein binding | APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT | 3.81608 |
[BP] GO:0032501 | multicellular organismal process | ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRB, F10, F3, FABP4, HSD11B2, HSD17B2, IGF1R, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, SRC, TNKS2, TYR | 3.78716 |
[BP] GO:0048583 | regulation of response to stimulus | ABCB1, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD1, DYRK1A, ESR1, ESR2, ESRRA, F10, F3, FABP4, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, XDH | 3.78716 |
[BP] GO:1902531 | regulation of intracellular signal transduction | ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DYRK1A, ESR1, F10, F3, FLT3, IGF1R, KDR, KIT, MET, MMP9, PTPN1, SRC, XDH | 3.74592 |
[BP] GO:0042981 | regulation of apoptotic process | ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HCAR2, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, TERT, XDH | 3.73959 |
[BP] GO:0048584 | positive regulation of response to stimulus | ADORA1, AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, ESRRA, F10, F3, FABP4, FLT3, KDR, KIT, MET, MMP2, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH | 3.69257 |
[BP] GO:1901564 | organonitrogen compound metabolic process | ACHE, AKR1B1, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DRD1, DYRK1A, ESR1, F10, F3, FLT3, FUT7, GBA2, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, TYR, XDH | 3.66892 |
[BP] GO:0051173 | positive regulation of nitrogen compound metabolic process | ADORA1, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DRD1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, KIT, MET, MMP9, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, XDH | 3.62666 |
[BP] GO:0033559 | unsaturated fatty acid metabolic process | ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 3.58629 |
[BP] GO:0019369 | arachidonic acid metabolic process | CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 3.55371 |
[BP] GO:1902533 | positive regulation of intracellular signal transduction | ADORA1, AKR1B1, APP, AXL, BCL2, CYP1B1, F10, F3, FLT3, KDR, KIT, MET, PTPN1, SRC, XDH | 3.53711 |
[BP] GO:0008210 | estrogen metabolic process | CYP19A1, CYP1B1, HSD17B1, HSD17B2 | 3.5319 |
[BP] GO:0009698 | phenylpropanoid metabolic process | CYP1A1, CYP2A13, CYP2A6 | 3.5319 |
[BP] GO:0009804 | coumarin metabolic process | CYP1A1, CYP2A13, CYP2A6 | 3.5319 |
[BP] GO:0042493 | response to drug | ABCB1, AKR1B1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, DRD1, FABP3, HSD11B2, KDR, SRC | 3.47073 |
[BP] GO:0006690 | icosanoid metabolic process | ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 3.43605 |
[BP] GO:0010038 | response to metal ion | APP, BCL2, CA2, CYP1A1, CYP1A2, FABP4, KIT, MMP9, TERT | 3.43523 |
[BP] GO:0051716 | cellular response to stimulus | AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, PTPN1, SRC, TERT | 3.42694 |
[BP] GO:0009628 | response to abiotic stimulus | ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, DRD1, HSD11B2, KIT, MMP2, PPARA, SRC, TERT, TYR | 3.4213 |
[BP] GO:0034502 | protein localization to chromosome | AURKB, ESR1, TERT, TNKS, TNKS2 | 3.40233 |
[BP] GO:0018193 | peptidyl-amino acid modification | AURKB, AXL, BCL2, CSNK2A1, DRD1, DYRK1A, F10, FLT3, IGF1R, KDR, KIT, MET, SRC, TNKS | 3.39229 |
[BP] GO:0031325 | positive regulation of cellular metabolic process | ADORA1, APP, AURKB, BCL2, CDC25B, DNMT1, DRD1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, IGF1R, KDR, KIT, MET, MMP9, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, XDH | 3.36164 |
[BP] GO:0010604 | positive regulation of macromolecule metabolic process | ADORA1, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DRD1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, KIT, MET, MMP9, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, XDH | 3.32407 |
[BP] GO:0006796 | phosphate-containing compound metabolic process | ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, PTPN1, SRC, TNKS, XDH | 3.31067 |
[BP] GO:0030522 | intracellular receptor signaling pathway | ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, SRC | 3.2837 |
[BP] GO:0008283 | cell proliferation | ABCB1, ACHE, AURKB, BCL2, CYP1A1, ESR1, FLT3, KIT, MET, PIM1, SRC, TYR | 3.26891 |
[BP] GO:0009893 | positive regulation of metabolic process | ADORA1, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DRD1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, IGF1R, KDR, KIT, MET, MMP9, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, XDH | 3.25826 |
[BP] GO:0051098 | regulation of binding | APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT, TNKS | 3.2308 |
[BP] GO:0001666 | response to hypoxia | ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, SRC, TERT | 3.19498 |
[BP] GO:0022414 | reproductive process | AKR1B1, ALPL, APP, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, DRD1, ESR1, ESRRB, HSD11B2, HSD17B2, KIT, MMP2, MMP9, SRC | 3.16858 |
[BP] GO:0036293 | response to decreased oxygen levels | ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, SRC, TERT | 3.1074 |
[BP] GO:2001225 | regulation of chloride transport | ABCB1, CA2, CA7 | 3.08979 |
[BP] GO:0097267 | omega-hydroxylase P450 pathway | CYP1A1, CYP1A2, CYP1B1 | 3.08979 |
[BP] GO:0048523 | negative regulation of cellular process | ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DRD1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, XDH | 3.08979 |
[BP] GO:0006793 | phosphorus metabolic process | ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, PTPN1, SRC, TNKS, XDH | 3.04448 |
[BP] GO:0043401 | steroid hormone mediated signaling pathway | ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC | 2.96294 |
[BP] GO:0002320 | lymphoid progenitor cell differentiation | BCL2, FLT3, KIT | 2.96294 |
[BP] GO:0048511 | rhythmic process | AXL, BCL2, CSNK2A1, DYRK1A, ESR1, KIT, PPARA, SRC | 2.93294 |
[BP] GO:0043066 | negative regulation of apoptotic process | ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, TERT | 2.86193 |
[BP] GO:0070482 | response to oxygen levels | ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, SRC, TERT | 2.86193 |
[BP] GO:2000021 | regulation of ion homeostasis | ADORA1, BCL2, CA2, CA7, DRD1, KDR, SRC | 2.85483 |
[BP] GO:0042738 | exogenous drug catabolic process | CYP1A2, CYP2A6, CYP3A4 | 2.85425 |
[BP] GO:0051896 | regulation of protein kinase B signaling | AXL, F10, F3, KIT, MET, SRC, XDH | 2.82027 |
[BP] GO:0006631 | fatty acid metabolic process | ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA | 2.82005 |
[BP] GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PTPN1, SRC | 2.81434 |
[BP] GO:0080134 | regulation of response to stress | ABCB1, ADORA1, APP, CDK6, CYP19A1, DYRK1A, ESR1, F3, FABP4, IGF1R, MET, MMP2, PPARA, PTPN1, SRC, TERT, XDH | 2.79044 |
[BP] GO:0050804 | modulation of chemical synaptic transmission | ACHE, ADORA1, APP, BACE1, CA2, CA7, DRD1, KIT | 2.7817 |
[BP] GO:0099177 | regulation of trans-synaptic signaling | ACHE, ADORA1, APP, BACE1, CA2, CA7, DRD1, KIT | 2.7817 |
[BP] GO:0006703 | estrogen biosynthetic process | CYP19A1, HSD17B1, HSD17B2 | 2.76459 |
[BP] GO:0009115 | None | AOX1, XDH | 2.76325 |
[BP] GO:0009636 | response to toxic substance | AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, DRD1, KDR, SRC | 2.76325 |
[BP] GO:0044092 | negative regulation of molecular function | ADORA3, APP, AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS | 2.76157 |
[BP] GO:0048519 | negative regulation of biological process | ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DRD1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HCAR2, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, XDH | 2.75457 |
[BP] GO:1901701 | cellular response to oxygen-containing compound | AKR1B1, APP, AXL, CDK6, CYP1B1, DNMT1, DRD1, ESR1, IGF1R, MMP2, MMP9, SRC | 2.74926 |
[BP] GO:0051130 | positive regulation of cellular component organization | APP, AURKB, AXL, BCL2, DNMT1, ESR1, IGF1R, KDR, KIT, MET, MMP1, MMP9, SRC, TNKS, TNKS2 | 2.74764 |
[BP] GO:0010243 | response to organonitrogen compound | AKR1B1, APP, DNMT1, DRD1, FABP3, FLT3, HSD11B2, IGF1R, MMP2, PPARA, SRC, TYR | 2.71462 |
[BP] GO:0060065 | uterus development | CYP19A1, ESR1, SRC | 2.69093 |
[BP] GO:0032846 | positive regulation of homeostatic process | AURKB, CA2, CA7, DRD1, HCAR2, TNKS, TNKS2 | 2.67968 |
[BP] GO:1903727 | positive regulation of phospholipid metabolic process | FABP3, FLT3, KIT, SRC | 2.66557 |
[BP] GO:0017144 | drug metabolic process | ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, DRD1 | 2.65605 |
[BP] GO:0051897 | positive regulation of protein kinase B signaling | AXL, F10, F3, KIT, MET, SRC | 2.65605 |
[BP] GO:0042592 | homeostatic process | ADORA1, AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, DRD1, ESR1, FABP3, FABP4, FLT3, MET, SRC, TERT | 2.62204 |
[BP] GO:1901568 | fatty acid derivative metabolic process | ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 2.61569 |
[BP] GO:0070198 | None | TERT, TNKS, TNKS2 | 2.61569 |
[BP] GO:0030540 | female genitalia development | AXL, CYP19A1, ESR1 | 2.53656 |
[BP] GO:1901575 | None | ACHE, ADORA1, AKR1B10, AOX1, AURKB, BACE1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, FUT7, GBA2, XDH | 2.51816 |
[BP] GO:0008610 | lipid biosynthetic process | ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 2.50984 |
[BP] GO:0018105 | peptidyl-serine phosphorylation | AURKB, BCL2, DRD1, DYRK1A, SRC, TNKS | 2.48191 |
[BP] GO:1904355 | positive regulation of telomere capping | AURKB, TNKS, TNKS2 | 2.46305 |
[BP] GO:0001676 | long-chain fatty acid metabolic process | CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 2.462 |
[BP] GO:0009755 | hormone-mediated signaling pathway | ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC | 2.462 |
[BP] GO:0044093 | positive regulation of molecular function | ABCB1, ADORA1, APP, AURKB, BCL2, CDC25B, ESR1, ESR2, F3, FLT3, KIT, MET, MMP9, PTPN1, SRC, TERT, TNKS, XDH | 2.46128 |
[BP] GO:0010562 | positive regulation of phosphorus metabolic process | ADORA1, APP, BCL2, CDC25B, DRD1, ESRRB, FABP3, FLT3, KDR, KIT, MMP9, PTPN1, SRC, XDH | 2.46056 |
[BP] GO:0045937 | positive regulation of phosphate metabolic process | ADORA1, APP, BCL2, CDC25B, DRD1, ESRRB, FABP3, FLT3, KDR, KIT, MMP9, PTPN1, SRC, XDH | 2.46056 |
[BP] GO:1901698 | response to nitrogen compound | AKR1B1, APP, DNMT1, DRD1, FABP3, FLT3, HSD11B2, IGF1R, MMP2, PPARA, SRC, TYR | 2.44373 |
[BP] GO:0016137 | None | AKR1B1, AKR1B10, GBA2 | 2.40377 |
[BP] GO:0071407 | cellular response to organic cyclic compound | ALPL, APP, CYP1A1, CYP1B1, DRD1, ESR1, FLT3, SRC | 2.39722 |
[BP] GO:0000302 | response to reactive oxygen species | AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC | 2.38037 |
[BP] GO:0046110 | None | AOX1, XDH | 2.37641 |
[BP] GO:0032849 | positive regulation of cellular pH reduction | CA2, CA7 | 2.37641 |
[BP] GO:0032210 | regulation of telomere maintenance via telomerase | AURKB, SRC, TNKS, TNKS2 | 2.37153 |
[BP] GO:0009966 | regulation of signal transduction | ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DYRK1A, ESR1, ESR2, F10, F3, FLT3, IGF1R, KDR, KIT, MET, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH | 2.35389 |
[BP] GO:0006721 | terpenoid metabolic process | AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4 | 2.35389 |
[BP] GO:0051900 | regulation of mitochondrial depolarization | BCL2, KDR, SRC | 2.35264 |
[BP] GO:0042542 | response to hydrogen peroxide | AKR1B1, AXL, BCL2, CYP1B1, SRC | 2.34319 |
[BP] GO:0034614 | cellular response to reactive oxygen species | AKR1B1, AXL, CYP1B1, MMP9, SRC | 2.34319 |
[BP] GO:0019216 | regulation of lipid metabolic process | ADORA1, CYP1A1, FABP3, FLT3, HCAR2, KIT, PPARA, SRC | 2.32483 |
[BP] GO:0046686 | response to cadmium ion | CYP1A2, KIT, MMP9, TERT | 2.30238 |
[BP] GO:0048608 | reproductive structure development | AXL, BCL2, CYP19A1, ESR1, HSD17B2, KIT, SRC | 2.28703 |
[BP] GO:0032787 | None | ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, PPARA | 2.28703 |
[BP] GO:0018209 | peptidyl-serine modification | AURKB, BCL2, DRD1, DYRK1A, SRC, TNKS | 2.28579 |
[BP] GO:0003006 | developmental process involved in reproduction | ALPL, AXL, BCL2, CDC25B, CYP19A1, ESR1, ESRRB, HSD17B2, KIT, SRC | 2.28372 |
[BP] GO:0019538 | protein metabolic process | ACHE, ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DYRK1A, ESR1, F10, F3, FLT3, FUT7, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2 | 2.26964 |
[BP] GO:0006805 | xenobiotic metabolic process | CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 | 2.25989 |
[BP] GO:0048585 | negative regulation of response to stimulus | ADORA1, BCL2, CDK6, CYP19A1, DRD1, DYRK1A, ESR1, ESR2, IGF1R, MET, MMP9, PPARA, PTPN1, SRC, TERT, XDH | 2.25772 |
[BP] GO:1904356 | regulation of telomere maintenance via telomere lengthening | AURKB, SRC, TNKS, TNKS2 | 2.20441 |
[BP] GO:0042325 | regulation of phosphorylation | ADORA1, APP, BCL2, CDC25B, DRD1, ESRRB, FABP4, FLT3, IGF1R, KDR, KIT, MMP9, PPARA, PTPN1, SRC, XDH | 2.20032 |
[BP] GO:1904707 | positive regulation of vascular smooth muscle cell proliferation | MMP2, MMP9, TERT | 2.20032 |
[BP] GO:0030520 | intracellular estrogen receptor signaling pathway | ESR1, ESR2, SRC | 2.20032 |
[BP] GO:0009987 | cellular process | ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DNMT1, DRD1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HCAR2, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, TYR, XDH | 2.19527 |
[BP] GO:0035690 | cellular response to drug | AKR1B1, AXL, CDK6, CYP1B1, DRD1, KDR, SRC | 2.19512 |
[BP] GO:0050806 | positive regulation of synaptic transmission | ADORA1, APP, CA2, CA7, DRD1 | 2.15239 |
[BP] GO:0009404 | toxin metabolic process | CYP1A1, CYP1A2, CYP1B1 | 2.14997 |
[BP] GO:0070213 | None | TNKS, TNKS2 | 2.14997 |
[BP] GO:0006145 | None | AOX1, XDH | 2.14997 |
[BP] GO:0018894 | dibenzo-p-dioxin metabolic process | CYP1A1, CYP1A2 | 2.14997 |
[BP] GO:0065009 | regulation of molecular function | ABCB1, ADORA1, ADORA3, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DRD1, ESR1, ESR2, F3, FABP4, FLT3, IGF1R, KIT, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, TNKS, XDH | 2.14132 |
[BP] GO:0045834 | positive regulation of lipid metabolic process | FABP3, FLT3, KIT, PPARA, SRC | 2.13755 |
[BP] GO:2000573 | positive regulation of DNA biosynthetic process | AURKB, SRC, TNKS, TNKS2 | 2.12675 |
[BP] GO:1903409 | reactive oxygen species biosynthetic process | CYP1A1, CYP1A2, CYP1B1 | 2.11237 |
[BP] GO:0006720 | isoprenoid metabolic process | AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4 | 2.10987 |
[BP] GO:1902532 | negative regulation of intracellular signal transduction | BCL2, DYRK1A, ESR1, IGF1R, MET, MMP9, PTPN1, SRC, XDH | 2.08712 |
[BP] GO:0044267 | cellular protein metabolic process | ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DYRK1A, ESR1, F10, FLT3, FUT7, IGF1R, KDR, KIT, MET, MMP1, MMP2, PIM1, PTPN1, SRC, TNKS, TNKS2 | 2.05917 |
[BP] GO:0019220 | regulation of phosphate metabolic process | ADORA1, APP, BCL2, CDC25B, DRD1, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MMP9, PPARA, PTPN1, SRC, XDH | 2.04183 |
[BP] GO:0006706 | steroid catabolic process | CYP19A1, CYP1A2, CYP3A4 | 2.01852 |
[BP] GO:1904353 | regulation of telomere capping | AURKB, TNKS, TNKS2 | 2.01852 |
[BP] GO:0050790 | regulation of catalytic activity | ADORA1, ADORA3, APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, ESR1, F3, FABP4, FLT3, IGF1R, KIT, MMP9, PTPN1, SRC, TERT, TNKS, XDH | 2.01793 |
[BP] GO:0051174 | regulation of phosphorus metabolic process | ADORA1, APP, BCL2, CDC25B, DRD1, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MMP9, PPARA, PTPN1, SRC, XDH | 2.00616 |
[BP] GO:0051054 | positive regulation of DNA metabolic process | AURKB, DNMT1, IGF1R, SRC, TNKS, TNKS2 | 2.00132 |
[CC] GO:0044432 | endoplasmic reticulum part | APP, BACE1, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, F10, FLT3, GBA2, HSD11B1, HSD11B2, HSD17B2, PTPN1 | 3.99156 |
[CC] GO:0016020 | membrane | ABCB1, ACHE, ADORA1, ADORA3, ALOX5, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, ESR1, F10, F3, FLT3, FUT7, GBA2, HCAR2, HSD11B1, HSD11B2, HSD17B2, IGF1R, KDR, KIT, MET, MMP2, PIM1, PTPN1, SRC, TERT, TNKS, TNKS2, TYR | 2.79044 |
[CC] GO:0005789 | endoplasmic reticulum membrane | BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, GBA2, HSD11B1, HSD11B2, HSD17B2 | 2.61192 |
[CC] GO:0044444 | cytoplasmic part | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, APP, AURKB, BACE1, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KDR, KIT, MMP2, MMP9, PIM1, PTPN1, SRC, TERT, TNKS, TNKS2, TYR, XDH | 2.462 |
[CC] GO:0031233 | None | CA4, F10, F3 | 2.30238 |
[CC] GO:0043227 | membrane-bounded organelle | ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DRD1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, IGF1R, KDR, KIT, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, TYR, XDH | 2.28185 |
[MF] GO:0046914 | transition metal ion binding | ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DNMT1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, TNKS, TYR, XDH | 18.4336 |
[MF] GO:0004089 | carbonate dehydratase activity | CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 | 17.2584 |
[MF] GO:0003824 | catalytic activity | ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DNMT1, DYRK1A, F10, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PTPN1, SRC, TERT, TNKS, TNKS2, TYR, XDH | 14.3678 |
[MF] GO:0043167 | ion binding | ABCB1, ACHE, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DNMT1, DRD1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, TYR, XDH | 12.7218 |
[MF] GO:0016836 | hydro-lyase activity | CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 | 10.8835 |
[MF] GO:0016835 | carbon-oxygen lyase activity | CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 | 9.63039 |
[MF] GO:0043169 | cation binding | ACHE, ALOX5, ALPL, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DNMT1, DRD1, ESR1, ESR2, ESRRA, ESRRB, F10, KIT, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, TERT, TNKS, TNKS2, TYR, XDH | 8.38123 |
[MF] GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 | 8.33682 |
[MF] GO:0008270 | zinc ion binding | CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DNMT1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PPARA, PTPN1, TNKS | 8.29262 |
[MF] GO:0046872 | metal ion binding | ALOX5, ALPL, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DNMT1, ESR1, ESR2, ESRRA, ESRRB, F10, KIT, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, TERT, TNKS, TNKS2, TYR, XDH | 7.39772 |
[MF] GO:0070330 | aromatase activity | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 | 6.85566 |
[MF] GO:0005506 | iron ion binding | ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, XDH | 6.70083 |
[MF] GO:0016491 | oxidoreductase activity | AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH | 6.42675 |
[MF] GO:0016829 | lyase activity | CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 | 6.19074 |
[MF] GO:0004497 | monooxygenase activity | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, TYR | 5.98656 |
[MF] GO:0019825 | oxygen binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 | 5.26786 |
[MF] GO:0020037 | heme binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, SRC | 5.11881 |
[MF] GO:0005496 | steroid binding | CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1 | 5.03424 |
[MF] GO:0016614 | oxidoreductase activity, acting on CH-OH group of donors | AKR1B1, AKR1B10, AOX1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH | 4.97709 |
[MF] GO:0046906 | tetrapyrrole binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, SRC | 4.94847 |
[MF] GO:0008144 | drug binding | ABCB1, ACHE, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, DRD1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, PPARA, SRC | 4.64127 |
[MF] GO:0016705 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, TYR | 4.60834 |
[MF] GO:0004714 | transmembrane receptor protein tyrosine kinase activity | AXL, FLT3, IGF1R, KDR, KIT, MET | 4.57178 |
[MF] GO:0048037 | cofactor binding | AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD11B2, HSD17B1, SRC, XDH | 4.43038 |
[MF] GO:0008395 | steroid hydroxylase activity | CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP3A4 | 4.42694 |
[MF] GO:0004713 | protein tyrosine kinase activity | AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, SRC | 4.16893 |
[MF] GO:0019199 | transmembrane receptor protein kinase activity | AXL, FLT3, IGF1R, KDR, KIT, MET | 4.03528 |
[MF] GO:0008289 | lipid binding | AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA | 3.81608 |
[MF] GO:0098531 | transcription factor activity, direct ligand regulated sequence-specific DNA binding | ESR1, ESR2, ESRRA, ESRRB, PPARA | 3.7426 |
[MF] GO:0004879 | nuclear receptor activity | ESR1, ESR2, ESRRA, ESRRB, PPARA | 3.7426 |
[MF] GO:0003707 | steroid hormone receptor activity | ESR1, ESR2, ESRRA, ESRRB, PPARA | 3.40233 |
[MF] GO:0033764 | steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 3.35759 |
[MF] GO:0004672 | protein kinase activity | AURKB, AXL, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC | 3.2723 |
[MF] GO:0016229 | steroid dehydrogenase activity | HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 3.25276 |
[MF] GO:0016725 | oxidoreductase activity, acting on CH or CH2 groups | CYP1A2, CYP3A4, XDH | 3.22197 |
[MF] GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 3.16522 |
[MF] GO:0038052 | RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding | ESR1, ESR2 | 2.76325 |
[MF] GO:0003845 | None | HSD11B1, HSD11B2 | 2.76325 |
[MF] GO:0008389 | None | CYP2A13, CYP2A6 | 2.76325 |
[MF] GO:0016903 | None | AKR1B1, AKR1B10, AOX1, XDH | 2.63308 |
[MF] GO:0016773 | phosphotransferase activity, alcohol group as acceptor | AURKB, AXL, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC | 2.60912 |
[MF] GO:0038023 | signaling receptor activity | ADORA1, ADORA3, AXL, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, IGF1R, KDR, KIT, MET, PPARA | 2.58366 |
[MF] GO:0060089 | molecular transducer activity | ADORA1, ADORA3, AXL, CDK6, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, IGF1R, KDR, KIT, MET, PPARA | 2.38357 |
[MF] GO:0070576 | vitamin D 24-hydroxylase activity | CYP1A1, CYP3A4 | 2.37641 |
[MF] GO:0009055 | electron transfer activity | AKR1B1, AOX1, CYP19A1, CYP1A2, XDH | 2.34319 |
[MF] GO:0042802 | identical protein binding | ACHE, AOX1, APP, BCL2, CSNK2A1, DYRK1A, ESR1, ESR2, FLT3, IGF1R, KDR, KIT, MET, MMP9, TERT, TYR, XDH | 2.32483 |
[MF] GO:0016301 | kinase activity | AURKB, AXL, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC | 2.30238 |
[MF] GO:0001223 | transcription coactivator binding | ESR1, PPARA, TERT | 2.30238 |
[MF] GO:0016772 | transferase activity, transferring phosphorus-containing groups | AURKB, AXL, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC, TERT | 2.26958 |
[MF] GO:0034056 | estrogen response element binding | ESR1, ESR2 | 2.14997 |
[MF] GO:0034875 | caffeine oxidase activity | CYP1A2, CYP3A4 | 2.14997 |
[MF] GO:0033695 | oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor | CYP1A2, CYP3A4 | 2.14997 |
[MF] GO:0036094 | small molecule binding | ABCB1, ADORA1, AOX1, AURKB, AXL, CDK6, CSNK2A1, DNMT1, DYRK1A, FABP3, FABP4, FLT3, HSD11B2, HSD17B1, IGF1R, KDR, KIT, MET, PIM1, SRC, XDH | 2.14654 |
[MF] GO:0004872 | receptor activity | ADORA1, ADORA3, AXL, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, IGF1R, KDR, KIT, MET, PPARA | 2.07882 |
KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
---|---|---|
Nitrogen metabolism_Homo sapiens_hsa00910 | CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 | 18.4912 |
Steroid hormone biosynthesis_Homo sapiens_hsa00140 | HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 | 10.5805 |
Ovarian steroidogenesis_Homo sapiens_hsa04913 | ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R | 7.7535 |
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 | 6.6931 |
Metabolic pathways_Homo sapiens_hsa01100 | DNMT1, AKR1B1, TYR, CYP3A4, GBA2, CYP19A1, HSD11B1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH | 5.5056 |
Chemical carcinogenesis_Homo sapiens_hsa05204 | HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 | 6.4327 |
MicroRNAs in cancer_Homo sapiens_hsa05206 | DNMT1, CDK6, ABCB1, BCL2, PIM1, CYP1B1, MMP9, MET, CDC25B | 4.8496 |
Pathways in cancer_Homo sapiens_hsa05200 | CDK6, FLT3, MMP1, MMP2, KIT, BCL2, MMP9, MET, IGF1R | 3.9961 |
Proteoglycans in cancer_Homo sapiens_hsa05205 | SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R | 4.0932 |
Retinol metabolism_Homo sapiens_hsa00830 | CYP2A6, CYP1A2, CYP1A1, AOX1, CYP3A4 | 4.3357 |
Adherens junction_Homo sapiens_hsa04520 | PTPN1, CSNK2A1, SRC, MET, IGF1R | 4.1018 |
Estrogen signaling pathway_Homo sapiens_hsa04915 | SRC, MMP2, MMP9, ESR1, ESR2 | 3.6594 |
Tryptophan metabolism_Homo sapiens_hsa00380 | CYP1A2, CYP1A1, AOX1, CYP1B1 | 3.9344 |
Bladder cancer_Homo sapiens_hsa05219 | SRC, MMP1, MMP2, MMP9 | 3.9234 |
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | CYP2A6, CYP1A2, AOX1, CYP3A4 | 3.1079 |
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | MMP2, BCL2, PIM1, F3 | 2.4946 |
PPAR signaling pathway_Homo sapiens_hsa03320 | FABP3, FABP4, MMP1, PPARA | 3.1079 |
Focal adhesion_Homo sapiens_hsa04510 | SRC, KDR, BCL2, MET, IGF1R | 2.3317 |
Rap1 signaling pathway_Homo sapiens_hsa04015 | SRC, KIT, KDR, MET, IGF1R | 2.2677 |
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | CDK6, KIT, KDR, BCL2, MET, IGF1R | 2.1578 |
Hepatitis B_Homo sapiens_hsa05161 | CDK6, SRC, BCL2, MMP9 | 2.0394 |
Acute myeloid leukemia_Homo sapiens_hsa05221 | FLT3, KIT, PIM1 | 2.1935 |
Endocytosis_Homo sapiens_hsa04144 | SRC, KIT, KDR, MET, IGF1R | 2.0141 |
Drug metabolism - other enzymes_Homo sapiens_hsa00983 | CYP2A6, CYP3A4, XDH | 2.4031 |
Central carbon metabolism in cancer_Homo sapiens_hsa05230 | FLT3, KIT, MET | 2.0394 |
Melanoma_Homo sapiens_hsa05218 | CDK6, MET, IGF1R | 2.0141 |
Prolactin signaling pathway_Homo sapiens_hsa04917 | SRC, ESR1, ESR2 | 2.0141 |
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | FLT3, MMP9, MET, IGF1R | 1.8038 |
Bile secretion_Homo sapiens_hsa04976 | ABCB1, CA2, CYP3A4 | 2.0141 |
cAMP signaling pathway_Homo sapiens_hsa04024 | HCAR2, ADORA1, DRD1, PPARA | 1.6893 |
Ras signaling pathway_Homo sapiens_hsa04014 | KIT, KDR, MET, IGF1R | 1.5385 |
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | FLT3, KIT, KDR, MET | 1.3324 |
Sphingolipid signaling pathway_Homo sapiens_hsa04071 | ADORA3, BCL2, ADORA1 | 1.5271 |
Jak-STAT signaling pathway_Homo sapiens_hsa04630 | BCL2, PIM1, AOX1 | 1.2397 |
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | FABP4, ADORA1 | 1.2619 |
Glioma_Homo sapiens_hsa05214 | CDK6, IGF1R | 1.19 |
VEGF signaling pathway_Homo sapiens_hsa04370 | SRC, KDR | 1.2224 |
Prostate cancer_Homo sapiens_hsa05215 | BCL2, IGF1R | 0.9996 |
GnRH signaling pathway_Homo sapiens_hsa04912 | SRC, MMP2 | 0.9983 |
Small cell lung cancer_Homo sapiens_hsa05222 | CDK6, BCL2 | 1.0014 |
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | CDC25B, IGF1R | 0.9555 |
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | SRC, MET | 1.0614 |
Gap junction_Homo sapiens_hsa04540 | SRC, DRD1 | 1.0002 |
Melanogenesis_Homo sapiens_hsa04916 | KIT, TYR | 0.9504 |
Hematopoietic cell lineage_Homo sapiens_hsa04640 | FLT3, KIT | 1.0002 |
Morphine addiction_Homo sapiens_hsa05032 | ADORA1, DRD1 | 0.9983 |
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | SRC, MET | 1.1627 |
Glycerolipid metabolism_Homo sapiens_hsa00561 | AKR1B10, AKR1B1 | 1.2397 |
Cholinergic synapse_Homo sapiens_hsa04725 | ACHE, BCL2 | 0.8959 |
Complement and coagulation cascades_Homo sapiens_hsa04610 | F10, F3 | 1.0601 |
Insulin resistance_Homo sapiens_hsa04931 | PTPN1, PPARA | 0.9027 |
HIF-1 signaling pathway_Homo sapiens_hsa04066 | BCL2, IGF1R | 0.9393 |
Caffeine metabolism_Homo sapiens_hsa00232 | CYP2A6, CYP1A2, XDH | 5.1067 |
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | ADORA3, ADORA1, DRD1 | 0.8431 |
NF-kappa B signaling pathway_Homo sapiens_hsa04064 | CSNK2A1, BCL2 | 0.9889 |
Serotonergic synapse_Homo sapiens_hsa04726 | APP, ALOX5 | 0.8959 |
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | SRC, ESR1 | 0.8827 |
Measles_Homo sapiens_hsa05162 | CDK6, CSNK2A1 | 0.7948 |
Toxoplasmosis_Homo sapiens_hsa05145 | ALOX5, BCL2 | 0.8827 |
Leukocyte transendothelial migration_Homo sapiens_hsa04670 | MMP2, MMP9 | 0.8827 |
Cell cycle_Homo sapiens_hsa04110 | CDK6, CDC25B | 0.8514 |
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | ESRRB, IGF1R | 0.7809 |
Tight junction_Homo sapiens_hsa04530 | CSNK2A1, SRC | 0.7846 |
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | ADORA3, ADORA1 | 0.6874 |
Alzheimer's disease_Homo sapiens_hsa05010 | BACE1, APP | 0.6874 |
Tuberculosis_Homo sapiens_hsa05152 | SRC, BCL2 | 0.6558 |
Epstein-Barr virus infection_Homo sapiens_hsa05169 | CSNK2A1, BCL2 | 0.6057 |
Viral carcinogenesis_Homo sapiens_hsa05203 | CDK6, SRC | 0.6057 |
HTLV-I infection_Homo sapiens_hsa05166 | TERT | 0.2274 |
MAPK signaling pathway_Homo sapiens_hsa04010 | CDC25B | 0.2275 |
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | SRC | 0.2739 |
Purine metabolism_Homo sapiens_hsa00230 | XDH | 0.3177 |
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | BCL2 | 0.3273 |
Herpes simplex infection_Homo sapiens_hsa05168 | CSNK2A1 | 0.3117 |
Calcium signaling pathway_Homo sapiens_hsa04020 | DRD1 | 0.317 |
Alcoholism_Homo sapiens_hsa05034 | DRD1 | 0.317 |
Parkinson's disease_Homo sapiens_hsa05012 | DRD1 | 0.3678 |
Apoptosis_Homo sapiens_hsa04210 | BCL2 | 0.3678 |
Chemokine signaling pathway_Homo sapiens_hsa04062 | SRC | 0.3116 |
Insulin signaling pathway_Homo sapiens_hsa04910 | PTPN1 | 0.3678 |
Platelet activation_Homo sapiens_hsa04611 | SRC | 0.3861 |
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | BCL2 | 0.3607 |
Galactose metabolism_Homo sapiens_hsa00052 | AKR1B10, AKR1B1 | 1.6916 |
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | PPARA | 0.3574 |
Oxytocin signaling pathway_Homo sapiens_hsa04921 | SRC | 0.3458 |
FoxO signaling pathway_Homo sapiens_hsa04068 | IGF1R | 0.3762 |
Wnt signaling pathway_Homo sapiens_hsa04310 | CSNK2A1 | 0.3678 |
Phospholipase D signaling pathway_Homo sapiens_hsa04072 | KIT | 0.3665 |
Neurotrophin signaling pathway_Homo sapiens_hsa04722 | BCL2 | 0.3865 |
Oocyte meiosis_Homo sapiens_hsa04114 | IGF1R | 0.3861 |
Hepatitis C_Homo sapiens_hsa05160 | PPARA | 0.3762 |
AMPK signaling pathway_Homo sapiens_hsa04152 | IGF1R | 0.3861 |
Axon guidance_Homo sapiens_hsa04360 | MET | 0.3814 |
TNF signaling pathway_Homo sapiens_hsa04668 | MMP9 | 0.4135 |
Dopaminergic synapse_Homo sapiens_hsa04728 | DRD1 | 0.3797 |
Tyrosine metabolism_Homo sapiens_hsa00350 | AOX1, TYR | 1.5983 |
Glucagon signaling pathway_Homo sapiens_hsa04922 | PPARA | 0.4406 |
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | SRC | 0.4477 |
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | IGF1R | 0.4515 |
ErbB signaling pathway_Homo sapiens_hsa04012 | SRC | 0.4639 |
Glycerophospholipid metabolism_Homo sapiens_hsa00564 | ACHE | 0.4515 |
Pancreatic secretion_Homo sapiens_hsa04972 | CA2 | 0.4515 |
Linoleic acid metabolism_Homo sapiens_hsa00591 | CYP1A2, CYP3A4 | 1.7073 |
Rheumatoid arthritis_Homo sapiens_hsa05323 | MMP1 | 0.4634 |
GABAergic synapse_Homo sapiens_hsa04727 | SRC | 0.4638 |
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | CSNK2A1 | 0.4636 |
Peroxisome_Homo sapiens_hsa04146 | XDH | 0.4774 |
Chronic myeloid leukemia_Homo sapiens_hsa05220 | CDK6 | 0.5177 |
Gastric acid secretion_Homo sapiens_hsa04971 | CA2 | 0.5167 |
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | AKR1B10, AKR1B1 | 1.5864 |
Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.5296 |
Pancreatic cancer_Homo sapiens_hsa05212 | CDK6 | 0.5394 |
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | IGF1R | 0.5394 |
Renal cell carcinoma_Homo sapiens_hsa05211 | MET | 0.5394 |
Long-term depression_Homo sapiens_hsa04730 | IGF1R | 0.5445 |
Amphetamine addiction_Homo sapiens_hsa05031 | DRD1 | 0.5379 |
Fructose and mannose metabolism_Homo sapiens_hsa00051 | AKR1B10, AKR1B1 | 1.6621 |
p53 signaling pathway_Homo sapiens_hsa04115 | CDK6 | 0.5309 |
Renin secretion_Homo sapiens_hsa04924 | ADORA1 | 0.5394 |
Colorectal cancer_Homo sapiens_hsa05210 | BCL2 | 0.5412 |
Shigellosis_Homo sapiens_hsa05131 | SRC | 0.5394 |
Non-small cell lung cancer_Homo sapiens_hsa05223 | CDK6 | 0.567 |
Arachidonic acid metabolism_Homo sapiens_hsa00590 | ALOX5 | 0.5412 |
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | CA2, CA4 | 1.8788 |
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | ESR1 | 0.6057 |
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | BCL2 | 0.5991 |
Malaria_Homo sapiens_hsa05144 | MET | 0.6057 |
Cocaine addiction_Homo sapiens_hsa05030 | DRD1 | 0.6057 |
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | AOX1 | 0.6057 |
Sphingolipid metabolism_Homo sapiens_hsa00600 | GBA2 | 0.6057 |
ABC transporters_Homo sapiens_hsa02010 | ABCB1 | 0.6124 |
Cysteine and methionine metabolism_Homo sapiens_hsa00270 | DNMT1 | 0.6087 |
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | HSD11B2 | 0.6558 |
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | FUT7 | 0.7275 |
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | AOX1 | 0.7493 |
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | FUT7 | 0.7809 |
Collecting duct acid secretion_Homo sapiens_hsa04966 | CA2 | 0.7729 |
Other glycan degradation_Homo sapiens_hsa00511 | GBA2 | 0.8827 |
Folate biosynthesis_Homo sapiens_hsa00790 | ALPL | 0.9504 |
Vitamin B6 metabolism_Homo sapiens_hsa00750 | AOX1 | 1.1948 |