TCM Prescription: Tian Ma Gou Teng Granules



Prescription Description
Prescription IDTCMF5403
Pinyin NameTian Ma Gou Teng Ke Li
Chinese Name天麻钩藤颗粒
English NameTian Ma Gou Teng Granules
Function Description头痛, 眩晕, 耳鸣, 震颤, 失眠
IndicationsTinnitus disorder, Vertigo disorder, Hypertension
Disease ICD-11 Category SC75 [Tinnitus disorder (TM1), 耳鸣 (TM1) ];
SD22 [Vertigo disorder (TM1), 眩晕 (TM1) ];
BA2Z [Hypotension, unspecified, 低血压,未特指的 ];
Human Tissues Associated with IndicationBrain, Heart, Blood
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2090 Gastrodia elata 天麻 TCMH2090
TCMH695 Uncaria rhynchophylla 钩藤 TCMH695 ITSAM939-14
TCMH1937 Concha haliotidis 石决明 TCMH1937
TCMH2641 Gardenia jasminoides 栀子 TCMH2641 ITSAJ4473-14
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
TCMH1588 Achyranthes bidentata 牛膝 TCMH1588 ITSAJ4612-14
TCMH524 Eucommia ulmoides 杜仲 TCMH524 ITSAM1588-14
TCMH2473 Leonurus japonicus 益母草 TCMH2473 ITSAN1807-14
TCMH1791 Loranthus parasiticus 桑寄生 TCMH1791
TCMH1963 Caulis polygoni multiflori 首乌藤 TCMH1963
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT304 MMP14 Matrix metalloproteinase 14 Hydrolase P50281
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT567 DNMT1 DNA (cytosine-5)-methyltransferase 1 Transferase P26358
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT907 FDPS Farnesyl diphosphate synthase Lyase P14324


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1208 Escherichia coli K12
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1319 Corynebacterium xerosis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1354 Streptococcus mutans UA159
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 13.2881
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 12.4945
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, FABP3, GRIK5, GRM5, HSD17B2, IGF1R, MMP2, MMP9, PPARA, RORC, SRC, TYR 9.06685
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, KDR, KIT, MMP9, SRC, TERT 8.67921
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CA2, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD17B2, IGF1R, KDR, KIT, MMP2, PPARA, RORC, SRC, TYR 8.6731
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CA2, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD17B2, IGF1R, KDR, KIT, MMP2, MMP9, PPARA, RORC, SRC, TERT, TYR 8.50522
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, FABP3, PPARA, SLC1A1 8.3354
[BP] GO:0007215 None APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.18917
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, BACE1, CA2, CA7, DRD1, DRD2, GRIK5, GRM1, GRM3, GRM5, GRM8, KIT 8.11668
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, BACE1, CA2, CA7, DRD1, DRD2, GRIK5, GRM1, GRM3, GRM5, GRM8, KIT 8.11668
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FDPS, FUT7, GLO1, PIM1, PPARA, TYR, XDH 8.08363
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HSD17B1, HSD17B2, KDR, KIT, MET, PPARA, SLC1A1, SRC, TERT, TNKS, TNKS2, XDH 7.80583
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP3, FABP4, FDPS, FUT7, HSD17B1, HSD17B2, KIT, MET, PPARA 7.32478
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, FABP3, PPARA, SLC1A1 6.85257
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, KIT, MMP2, MMP9, RORC, SRC, TERT 6.38097
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, FLT3, GRM1, KDR, KIT, MET, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 6.25137
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, FLT3, GRM1, KDR, KIT, MET, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 6.22933
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.18932
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP2, PIM1, PPARA, PTPN1, PTPRS, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 5.88859
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DYRK1A, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, KIT, MET, MMP9, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 5.82769
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, DRD2, GRM1, GRM3, GRM5, GRM8 5.78839
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CYP1A1, CYP1B1, DNMT1, DRD1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, KIT, MMP2, RORC, SRC 5.78391
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DNMT1, DRD1, FABP3, FLT3, GRM5, IGF1R, KIT, MMP2, PPARA, SRC 5.75353
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DYRK1A, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, KIT, MET, MMP9, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 5.73709
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA3, CDC25B, CSNK2A1, DRD1, DRD2, DYRK1A, FDPS, FLT3, IGF1R, KDR, KIT, MET, PIM1, PTPN1, PTPRS, SRC, TNKS, XDH 5.53447
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, PTPRS, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 5.49537
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, FABP4, FLT3, GRIK5, GRM1, GRM5, IGF1R, KDR, KIT, MMP2, MMP9, PTPN1, RORC, SRC, TERT, TOP2A 5.41712
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, FLT3, RORC, SRC, TYR 5.26331
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, FABP3, FLT3, GRIK5, GRM1, GRM5, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 5.26331
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DYRK1A, FABP4, FLT3, FUT7, GLO1, HSD17B2, KDR, KIT, MET, MMP2, MMP9, PIM1, PPARA, PTPRS, RORC, SRC, TERT, TNKS2, TOP2A, TYR 5.22088
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA3, CDC25B, CSNK2A1, DRD1, DRD2, DYRK1A, FDPS, FLT3, IGF1R, KDR, KIT, MET, PIM1, PTPN1, PTPRS, SRC, TNKS, XDH 5.18447
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC1A1, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 5.16768
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, FLT3, GLO1, GRIK5, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, TOP2A, XDH 5.04474
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 4.95924
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 4.95924
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, FLT3, GLO1, GRIK5, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTPN1, SRC, TERT, TOP2A, XDH 4.95924
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FDPS, HSD17B1, HSD17B2 4.8748
[BP] GO:0010038 response to metal ion ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, DRD2, FABP4, KIT, MMP9, TERT 4.8748
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CA3, CYP1A1, CYP1B1, DRD1, DRD2, KDR, SRC 4.84498
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, DRD2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, KIT, MET, MMP2, MMP9, PTPN1, SRC, TNKS, TNKS2 4.80079
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7, GRM5 4.78981
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, FDPS, TYR 4.73028
[BP] GO:0006811 None ABCB1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, FABP3, GRIA2, GRIA4, GRIK5, PPARA, SLC1A1 4.72435
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, PIM1, SRC 4.68136
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 4.65394
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TERT 4.57594
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP3, FABP4, FDPS, FUT7, KIT, MET, PPARA 4.49881
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APEX1, APP, AXL, BCL2, CA12, CA2, CA7, DRD1, DRD2, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, MET, SRC, TERT 4.4525
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA3, CA6, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HSD17B2, IGF1R, KDR, KIT, MMP2, MMP9, PPARA, PTPN1, RORC, SRC, TERT, TOP2A, TYR 4.43104
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD2, DYRK1A, KIT, PPARA, RORC, SRC, TOP2A 4.4106
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, FLT3, GRM1, KDR, KIT, MET, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 4.4106
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTPN1, SRC, TERT 4.38893
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 4.25495
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 4.24566
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.24566
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.19819
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, KIT, MMP9, PPARA, PTPN1, SRC, XDH 4.12084
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, KIT, MMP9, PPARA, PTPN1, SRC, XDH 4.06648
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, PTPRS, RORC, SLC1A1, SRC, TERT, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH 4.04199
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC, TNKS 4.01609
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, BCL2, CDC25B, CSNK2A1, CYP1B1, DNMT1, DRD2, FABP3, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, PIM1, SRC, TERT, XDH 3.93879
[BP] GO:0007193 None ADORA1, DRD2, GRM1, GRM3, GRM5, GRM8 3.93174
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, FABP3, FLT3, HSD17B2, RORC, SRC, TYR 3.91747
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, FLT3, GLO1, GRIK5, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, TERT, TOP2A, XDH 3.88136
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, GRIK5, GRM5, IGF1R, KDR, KIT, MET, MMP9, PPARA, PTPN1, SRC, TERT 3.88136
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, SRC 3.88136
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, FABP3, FABP4, GLO1, GRM3, GRM8, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PTPN1, PTPRS, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 3.86378
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, FABP3, FLT3, GRM1, GRM5, KDR, KIT, MMP9, PTPN1, SRC, XDH 3.86378
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, FABP3, FLT3, GRM1, GRM5, KDR, KIT, MMP9, PTPN1, SRC, XDH 3.86378
[BP] GO:0042493 response to drug ABCB1, AKR1B1, APEX1, AXL, BCL2, CA3, CA9, CYP1A1, CYP1B1, DRD1, DRD2, FABP3, KDR, SRC 3.86378
[BP] GO:0018212 peptidyl-tyrosine modification AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, SRC 3.86378
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CYP1B1, DRD2, FLT3, GRM1, KDR, KIT, MET, PTPN1, SRC, XDH 3.85802
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AXL, CYP1B1, DNMT1, DRD1, GRIK5, GRM5, IGF1R, MMP2, MMP9, RORC, SRC 3.75614
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, DRD1, DRD2, GRM1, KIT, MMP2, PPARA, SRC, TERT, TYR 3.71769
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, DNMT1, DRD1, DRD2, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, SRC, TYR 3.71769
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, FABP3, FLT3, KIT, PPARA, SRC 3.6464
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT 3.63413
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, DRD1, DRD2, KDR, SRC 3.59109
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DRD1, DRD2, DYRK1A, FLT3, GRM1, GRM5, IGF1R, KDR, KIT, MET, MMP9, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 3.59037
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, FABP4, GRM1, GRM5, GRM8, HSD17B2, IGF1R, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, RORC, SRC, TNKS2, TYR 3.51246
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, DRD1, DRD2, KDR, SRC, TNKS, TNKS2 3.4805
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 3.43693
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1 3.43141
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.42447
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, APP, BCL2, CDC25B, DNMT1, DRD2, DYRK1A, FLT3, GRM1, GRM5, KDR, KIT, MMP9, PTPN1, SRC, XDH 3.40162
[BP] GO:0007188 None ADORA1, DRD1, DRD2, GRM1, GRM3, GRM5, GRM8 3.3975
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, DNMT1, DRD1, DRD2, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, SRC, TYR 3.39477
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, DRD2, FLT3, GRM1, GRM5, KDR, KIT, MMP9, PTPN1, SRC, XDH 3.39228
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, FABP4, FLT3, GRM1, GRM5, IGF1R, KDR, KIT, MMP9, PPARA, PTPN1, SRC, XDH 3.38216
[BP] GO:0048169 None APP, DRD2, GRM5, KIT 3.37326
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DYRK1A, FLT3, GRM1, IGF1R, KDR, KIT, MET, MMP9, PTPN1, SRC, XDH 3.36653
[BP] GO:0042391 None ADORA1, APP, BCL2, DRD1, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC 3.33564
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, DNMT1, DRD1, DRD2, DYRK1A, FABP3, FLT3, GRM1, GRM5, IGF1R, KDR, KIT, MET, MMP9, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 3.33564
[BP] GO:0035235 None APP, GRIA2, GRIA4, GRIK5 3.32403
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 3.32076
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, FABP4, FLT3, GRM1, GRM5, IGF1R, KDR, KIT, MMP9, PTPN1, SRC, XDH 3.31673
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, FABP3, FABP4, GLO1, GRM3, GRM8, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PTPN1, PTPRS, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 3.31126
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DRD1, DRD2, DYRK1A, FLT3, GRM1, GRM5, IGF1R, KDR, KIT, MET, MMP9, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 3.31126
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, FABP4, FLT3, GRM1, KDR, KIT, MET, MMP2, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 3.29951
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, APP, DRD2, FLT3, GRM1, KDR, KIT, PTPN1, SRC, XDH 3.26731
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, TERT 3.26592
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC 3.26592
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.26592
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 3.26592
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, DRD2, FLT3, GRM1, GRM5, KDR, KIT, MMP9, PTPN1, SRC, XDH 3.23966
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, MMP9, SRC 3.18041
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DRD1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, SRC, TNKS, TOP2A 3.15721
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DRD1, DRD2, DYRK1A, FABP3, FLT3, GRM1, GRM5, IGF1R, KDR, KIT, MET, MMP9, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 3.1355
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC, TNKS 3.11463
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, DRD2, PPARA 3.11463
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, BCL2, CA3, CYP1B1, MMP9, SRC 3.0804
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT, TNKS 3.0804
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, TYR, XDH 3.08016
[BP] GO:0007187 None ADORA1, DRD1, DRD2, GRM1, GRM3, GRM5, GRM8 3.07101
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, DRD2, FABP4, GRM3, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS 3.07101
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, DRD2, MMP2, PPARA, SRC, TERT 3.07011
[BP] GO:0031399 regulation of protein modification process ADORA1, ALOX15, APP, BCL2, CDC25B, DNMT1, DRD1, DRD2, DYRK1A, FABP4, FLT3, GRM1, GRM5, IGF1R, KDR, KIT, MMP9, PTPN1, SRC, XDH 3.06804
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, DRD1, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 3.06723
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.06723
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AURKB, AXL, BCL2, DNMT1, DRD2, IGF1R, KDR, KIT, MET, MMP1, MMP9, SRC, TNKS, TNKS2 3.06626
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, DRD2 3.06626
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, GLO1, KIT, MMP9, RORC 3.06626
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.06626
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, DRD1, DRD2 3.05956
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, APP, CYP1A1, CYP1B1, DRD1, FLT3, RORC, SRC 3.03891
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, FLT3, HSD17B2, KDR, KIT, PPARA, PTPRS, SRC, TYR 3.01095
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, DRD2, MMP2, PPARA, SRC, TERT 3.00642
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, DRD1, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 2.95989
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 2.95989
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FDPS, FLT3, KIT, PPARA, RORC, SRC 2.93486
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DYRK1A, FLT3, HSD17B2, KDR, KIT, MMP9, PIM1, PPARA, PTPRS, RORC, SRC, TYR 2.9272
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, DRD1, DRD2, FABP3, FABP4, GRIK5, GRM1, GRM5, MET 2.87731
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, DRD1, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 2.87162
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5 2.86961
[BP] GO:0018958 None AKR1B1, BCL2, DRD1, DRD2, TYR 2.84461
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, DRD2, MMP2, PPARA, SRC, TERT 2.76795
[BP] GO:0007268 None DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 2.76449
[BP] GO:0098916 None DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 2.76449
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.76284
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, DRD1, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 2.76284
[BP] GO:0044070 regulation of anion transport ABCB1, ADORA1, CA2, CA7, GRM5 2.76018
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, APP, DRD2, FLT3, GRM1, IGF1R, KDR, KIT, PTPN1, SRC, XDH 2.75733
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA 2.73376
[BP] GO:1901989 None APEX1, APP, CDC25B, CYP1A1, TERT 2.71615
[BP] GO:0099536 None DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 2.7092
[BP] GO:0099537 None DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 2.7092
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, DNMT1, DRD1, GRM5, IGF1R, MMP2, SRC 2.70043
[BP] GO:0032845 None ADORA1, BCL2, DRD2, SRC, TNKS, TNKS2 2.70043
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PTPN1, SRC 2.70043
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC 2.62893
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AXL, BCL2, CBR1, CDC25B, CYP1A1, DRD1, DRD2, FABP4, FLT3, FUT7, GLO1, KDR, KIT, MET, MMP2, MMP9, PTPRS, RORC, SRC, TERT, TOP2A 2.60654
[BP] GO:0051234 None ABCB1, ACHE, ADORA1, ALOX15, ALOX5, APP, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, FABP3, GRIA2, GRIA4, GRIK5, KIT, MMP9, PPARA, SLC1A1, SRC, TERT, TNKS, XDH 2.59401
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.59401
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, TNKS, TNKS2 2.58998
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, DRD2, FABP4, FLT3, GRM1, GRM5, IGF1R, KIT, PTPN1, SRC, TNKS 2.58724
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CSNK2A1, DRD2, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, PIM1, TERT 2.57163
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, CSNK2A1, DNMT1, DRD2, DYRK1A, FLT3, GRM1, GRM5, KDR, KIT, MMP9, PTPN1, SRC, XDH 2.57163
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, FABP4, FLT3, GRM1, GRM3, GRM5, IGF1R, KIT, MMP9, PTPN1, SRC, TERT, TNKS, XDH 2.56466
[BP] GO:0048167 None ADORA1, APP, DRD1, DRD2, GRM5, KIT 2.56466
[BP] GO:0051179 None ABCB1, ACHE, ADORA1, ALOX15, ALOX5, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, FABP3, GRIA2, GRIA4, GRIK5, KIT, MMP9, PPARA, SLC1A1, SRC, TERT, TNKS, TNKS2, XDH 2.56398
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 2.55304
[BP] GO:0050730 None ADORA1, APP, FLT3, GRM5, KIT, PTPN1, SRC 2.55278
[BP] GO:0008542 None APP, DRD1, DRD2, KIT 2.47422
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, APP, DNMT1, DRD1, GRM5, IGF1R, MMP2, SRC 2.47073
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, BCL2, CYP1A1, FLT3, KIT, MET, PIM1, SRC, TYR 2.4702
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.46022
[BP] GO:0042752 None ADORA1, DRD2, PPARA, RORC, TOP2A 2.45248
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DYRK1A, FABP4, FLT3, GRM1, IGF1R, KDR, KIT, MET, MMP2, MMP9, PPARA, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 2.44053
[BP] GO:0006810 None ABCB1, ACHE, ADORA1, ALOX15, ALOX5, APP, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, FABP3, GRIA2, GRIA4, GRIK5, KIT, MMP9, PPARA, SLC1A1, SRC, TNKS, XDH 2.42606
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, BCL2, DRD1, DYRK1A, SRC, TNKS 2.42315
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, DRD2, FABP4, FLT3, GRM1, GRM5, IGF1R, KIT, PTPN1, SRC 2.42315
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1 2.42027
[BP] GO:0048168 None APP, DRD2, GRM5, KIT 2.39154
[BP] GO:0099566 None GRM1, GRM5 2.38545
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.38545
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, ALOX15, APP, AXL, BCL2, CA2, CA7, CYP19A1, DRD1, DRD2, GRIK5, GRM5, MMP9, PPARA, PTPN1, SRC, TERT 2.36797
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, DNMT1, DRD2, DYRK1A, FLT3, GRM1, GRM5, KDR, KIT, MMP9, PTPN1, SRC, XDH 2.36362
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, PTPRS, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 2.34514
[BP] GO:0007632 None APP, DRD1, DRD2, KIT 2.344
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.344
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.344
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, APP, DNMT1, DRD1, FLT3, GRM5, IGF1R, KIT, MMP2, SRC 2.34084
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, FLT3, GRM5, KIT, PTPN1, SRC 2.34084
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, DRD2, FLT3, GRM1, GRM5, KIT, PTPN1, SRC, TNKS 2.33266
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, GRM5, IGF1R, PPARA, SRC 2.32999
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, FDPS 2.31545
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CA3, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, KIT, MMP2, MMP9, PPARA, PTPN1, SRC, TERT, TOP2A 2.30479
[BP] GO:0046686 response to cadmium ion CYP1A2, KIT, MMP9, TERT 2.26828
[BP] GO:2001251 None DNMT1, SRC, TNKS, TNKS2, TOP2A 2.24499
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AXL, BCL2, CA1, CA2, CSNK2A1, CYP1B1, DNMT1, DRD1, DRD2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, KIT, MET, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2 2.24499
[BP] GO:0030336 None ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD2 2.24399
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2 2.23656
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA3, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DRD1, DRD2, FABP4, FLT3, GRM1, GRM3, GRM5, IGF1R, KIT, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, TNKS, XDH 2.23615
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.23615
[BP] GO:0044093 positive regulation of molecular function ABCB1, ADORA1, APP, AURKB, BCL2, CDC25B, DRD2, FLT3, GRM1, GRM5, KIT, MET, MMP9, PTPN1, SRC, TERT, TNKS, XDH 2.23465
[BP] GO:0018209 peptidyl-serine modification AURKB, BCL2, DRD1, DYRK1A, SRC, TNKS 2.21733
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, MMP2, MMP9 2.20534
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.20534
[BP] GO:0034502 protein localization to chromosome AURKB, TERT, TNKS, TNKS2 2.19833
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, FABP3, FABP4, FDPS, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 2.19371
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.18584
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, CDC25B, DRD2, FABP4, FLT3, GRM1, GRM5, IGF1R, KIT, PTPN1, SRC 2.18372
[BP] GO:0045787 positive regulation of cell cycle APEX1, APP, AURKB, CDC25B, CYP1A1, DRD2, SRC, TERT 2.18069
[BP] GO:0030098 lymphocyte differentiation AXL, BCL2, FLT3, FUT7, KIT, RORC 2.18069
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.18069
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, PPARA 2.18069
[BP] GO:0090068 positive regulation of cell cycle process APEX1, APP, AURKB, CDC25B, CYP1A1, DRD2, TERT 2.18069
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.15972
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.15972
[BP] GO:0070213 None TNKS, TNKS2 2.15972
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.15972
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, MET 2.15972
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.14809
[BP] GO:2000146 None ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD2 2.13674
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.13164
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.12736
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, APP, CYP19A1, DRD2, DYRK1A, FABP4, IGF1R, MET, MMP2, PPARA, PTPN1, PTPRS, SRC, TERT, XDH 2.12549
[BP] GO:0043269 regulation of ion transport ABCB1, ADORA1, APP, BCL2, CA2, CA7, DRD1, DRD2, GRM5, MMP9 2.12549
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, DRD1, KDR, SRC 2.12549
[BP] GO:0016311 None ALPL, APEX1, BCL2, CA3, CDC25B, PTPN1, PTPRS 2.11092
[BP] GO:0051128 regulation of cellular component organization ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, DNMT1, DRD2, GRIK5, IGF1R, KDR, KIT, MET, MMP1, MMP9, PTPN1, PTPRS, SRC, TNKS, TNKS2, TOP2A 2.11092
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.10887
[BP] GO:0009416 response to light stimulus APP, AURKB, BCL2, DRD1, DRD2, KIT, TYR 2.10711
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2 2.10711
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.10711
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, KIT, PPARA, SRC 2.09988
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, BCL2, DNMT1, KDR, MET, MMP9, SRC, TNKS, TNKS2 2.09983
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, FABP3, FABP4, FDPS, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 2.09513
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, FDPS 2.07295
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX15, BCL2, CYP19A1, DRD1, DRD2, DYRK1A, IGF1R, MET, MMP9, PPARA, PTPN1, PTPRS, SRC, TERT, XDH 2.0649
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, FDPS, HSD17B1, HSD17B2 2.05967
[BP] GO:0014910 regulation of smooth muscle cell migration APEX1, BCL2, SRC, TERT 2.04309
[BP] GO:0040014 regulation of multicellular organism growth APP, BCL2, DRD2, TNKS2 2.04309
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, DRD2, HSD17B1, HSD17B2 2.03392
[BP] GO:0071702 None ABCB1, ADORA1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, FABP3, PPARA, SLC1A1, TNKS 2.03392
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, MMP1, MMP2, MMP9, SRC, XDH 2.03093
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.02848
[BP] GO:0051271 None ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD2 2.02848
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, DRD2, FLT3, GRM1, GRM5, KIT, PTPN1, SRC 2.00811
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1 2.00662
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5 2.00662
[BP] GO:1901653 cellular response to peptide AKR1B1, APEX1, APP, GRM5, IGF1R, SRC 2.00583
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DRD2, DYRK1A, IGF1R, MET, MMP9, PTPN1, SRC, XDH 2.00124
[BP] GO:0021853 None DRD1, DRD2 2.00124
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.00124
[BP] GO:1904936 None DRD1, DRD2 2.00124
[BP] GO:0042321 None ADORA1, DRD2 2.00124
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, DRD2, FABP3, FABP4, KIT, MET 2.00124
[CC] GO:0098590 plasma membrane region ABCB1, ADORA1, CA2, CA4, CA9, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, MET, SLC1A1, SRC 4.43104
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA1, ADORA3, ALOX15, ALPL, APP, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CSNK2A1, DRD1, DRD2, FLT3, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, KIT, MET, MMP2, PIM1, PTPN1, PTPRS, SLC1A1, SRC, TERT 4.24566
[CC] GO:0044459 plasma membrane part ABCB1, ADORA1, ADORA3, ALOX15, APP, AXL, BACE1, CA2, CA4, CA9, DRD1, DRD2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, KIT, MET, PTPRS, SLC1A1, SRC 3.81217
[CC] GO:0043005 None ADORA1, APP, BACE1, CA2, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PTPRS, SRC, TUBB3 3.52636
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, AXL, BACE1, CA4, DRD1, DRD2, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PTPRS, SLC1A1 3.49883
[CC] GO:0044456 None ACHE, ADORA1, APP, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, PTPRS, SRC 3.43262
[CC] GO:0043227 membrane-bounded organelle ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, GRIA4, GRIK5, GRM1, GRM5, IGF1R, KDR, KIT, MMP2, MMP9, PIM1, PPARA, PTPN1, PTPRS, RORC, SLC1A1, SRC, TERT, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH 3.30359
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, APP, AXL, BACE1, DRD1, DRD2, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PTPRS, SLC1A1 3.24616
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.23711
[CC] GO:0043226 organelle ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, GRIA4, GRIK5, GRM1, GRM3, GRM5, IGF1R, KDR, KIT, MMP2, MMP9, PIM1, PPARA, PTPN1, PTPRS, RORC, SLC1A1, SRC, TERT, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH 3.17236
[CC] GO:0043197 None ADORA1, APP, DRD2, GRIA2, GRIA4, GRM3 3.0804
[CC] GO:0044309 None ADORA1, APP, DRD2, GRIA2, GRIA4, GRM3 3.06665
[CC] GO:0014069 None ADORA1, DRD2, GRIK5, GRM1, GRM3, GRM5, SRC 2.89972
[CC] GO:0099572 None ADORA1, DRD2, GRIK5, GRM1, GRM3, GRM5, SRC 2.89972
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA1, ADORA3, ALOX15, ALOX5, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, FLT3, FUT7, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD17B2, IGF1R, KDR, KIT, MET, MMP2, PIM1, PTPN1, PTPRS, SLC1A1, SRC, TERT, TNKS, TNKS2, TYR 2.82518
[CC] GO:0098794 None ADORA1, APP, DRD2, GRIA2, GRIA4, GRM3 2.58375
[CC] GO:0120025 None ADORA1, AKR1B1, APP, BACE1, CA2, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PTPRS, SRC, TUBB3 2.57163
[CC] GO:0042995 cell projection ADORA1, AKR1B1, APP, BACE1, CA2, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PTPRS, SRC, TUBB3 2.34084
[CC] GO:0030424 None APP, BACE1, CA2, DRD2, GRM3, PTPRS, TUBB3 2.31702
[CC] GO:0097060 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 2.09513
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, APP, AURKB, BACE1, BCL2, CA1, CA2, CA3, CA4, CA5A, CA5B, CA7, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, GRIA2, GRIA4, GRIK5, HSD17B1, HSD17B2, KDR, KIT, MMP2, MMP9, PIM1, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 2.00124
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 19.5235
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, APP, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, GLO1, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, TNKS, TYR, XDH 13.2932
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 12.4945
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 12.4101
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, FDPS, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH 11.6893
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, FABP3, FABP4, FDPS, FLT3, GLO1, HSD17B1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, PTPRS, RORC, SLC1A1, SRC, TERT, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH 11.0069
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1 9.35664
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.08363
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, FDPS, GLO1, KIT, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC1A1, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 7.42935
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DNMT1, GLO1, MMP1, MMP2, MMP9, PPARA, PTPN1, RORC, TNKS 6.98437
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, FDPS, GLO1, KIT, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC1A1, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 5.88859
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.38546
[MF] GO:0030594 None DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM5 4.24566
[MF] GO:0004713 protein tyrosine kinase activity AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, SRC 3.93879
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, TYR, XDH 3.88136
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 3.86378
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, DRD1, DRD2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, KIT, MET, PPARA, RORC 3.86378
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, PPARA, SRC, TOP2A 3.65248
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.48201
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 3.34709
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.32403
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, DRD1, DRD2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, KIT, MET 3.26731
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, DRD1, DRD2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, KIT, MET 3.26731
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, DRD1, DRD2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, KIT, MET, PPARA, RORC 3.25872
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, DRD1, DRD2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, KIT, MET, PPARA, RORC 3.08881
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2, XDH 2.80696
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, DRD1, DRD2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, KIT, MET, PPARA, RORC 2.76449
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.57163
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.50527
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC 2.47214
[MF] GO:0099583 None GRM1, GRM5 2.38545
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.344
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.344
[MF] GO:0004971 None GRIA2, GRIA4 2.15972
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2 2.14561
[MF] GO:0042802 identical protein binding ACHE, APP, BCL2, CSNK2A1, DRD2, DYRK1A, FLT3, GRIK5, IGF1R, KDR, KIT, MET, MMP9, TERT, TOP2A, TYR, XDH 2.12385
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.03392


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA3, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 20.9144
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.3894
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GRM3, GRIA2, GRM5, ADORA3, GRIK5, GRM8, ADORA1, DRD1, DRD2, GRM1, GRIA4 6.6276
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 6.51
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 5.7158
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, TUBB3, DRD1, DRD2, GRM1 4.7058
Metabolic pathways_Homo sapiens_hsa01100 FDPS, CBR1, DNMT1, ALOX15, AKR1B1, TYR, CYP19A1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH 3.8502
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 3.8502
MicroRNAs in cancer_Homo sapiens_hsa05206 DNMT1, ABCB1, BCL2, PIM1, CYP1B1, MMP9, MET, CDC25B 3.6979
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, KIT, BCL2, MMP9, MET, IGF1R 2.9957
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.6676
cAMP signaling pathway_Homo sapiens_hsa04024 GRIA2, ADORA1, DRD1, DRD2, PPARA, GRIA4 2.9957
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, IGF1R 2.9957
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2, DRD1, DRD2 3.3978
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KIT, KDR, DRD2, MET, IGF1R 2.9618
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, KIT, GRM8, GRM1 2.8582
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.9618
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP1A2, CYP1A1, CYP1B1 2.9296
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, GRM1 2.5089
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, GRM1, GRIA4 2.4954
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, IGF1R 2.2868
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP1A2, CYP1A1, CYP1B1 2.7802
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, DRD1, DRD2, GRIA4 2.1512
Endocytosis_Homo sapiens_hsa04144 SRC, KIT, KDR, MET, IGF1R 1.9367
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, KIT, PIM1 2.1658
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.5424
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.1347
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, DRD1, GRIA4 2.0565
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 2.0565
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15 2.1093
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, KIT, MET 2.0565
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.7435
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1 1.6381
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 KIT, KDR, BCL2, MET, IGF1R 1.5427
Ras signaling pathway_Homo sapiens_hsa04014 KIT, KDR, MET, IGF1R 1.5002
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, ALOX15 1.5427
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET 1.3005
Hepatitis B_Homo sapiens_hsa05161 SRC, BCL2, MMP9 1.3005
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.5002
Calcium signaling pathway_Homo sapiens_hsa04020 GRM5, DRD1, GRM1 1.1322
Prostate cancer_Homo sapiens_hsa05215 BCL2, IGF1R 0.9821
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 0.9796
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 0.9496
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.1322
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.2198
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 0.9834
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 0.9796
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 0.9602
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.2719
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2 0.8804
Melanogenesis_Homo sapiens_hsa04916 KIT, TYR 0.9408
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.8877
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 0.9248
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.1488
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.0711
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 0.9698
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2 1.1322
FoxO signaling pathway_Homo sapiens_hsa04068 GRM1, IGF1R 0.7696
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.1769
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 0.8465
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.8465
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.7447
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.2382
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.7488
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1 0.6887
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.6621
Alzheimer's disease_Homo sapiens_hsa05010 BACE1, APP 0.6621
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.633
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2, BCL2 1.3208
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.633
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.5748
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2155
HTLV-I infection_Homo sapiens_hsa05166 FDPS, TERT 0.4738
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.2608
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.2703
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.2851
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2917
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3102
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3038
Influenza A_Homo sapiens_hsa05164 FDPS 0.3038
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.2915
Apoptosis_Homo sapiens_hsa04210 BCL2 0.3503
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.3399
Measles_Homo sapiens_hsa05162 CSNK2A1 0.3512
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.3366
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.3503
Phagosome_Homo sapiens_hsa04145 TUBB3 0.3335
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 IGF1R 0.3503
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.3284
Platelet activation_Homo sapiens_hsa04611 SRC 0.3722
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3503
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.3553
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.3722
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.3722
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3722
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.3925
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.3722
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.3722
Axon guidance_Homo sapiens_hsa04360 MET 0.3675
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4193
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.4264
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4302
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.4423
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4302
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.5002
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4302
Taste transduction_Homo sapiens_hsa04742 GRM1 0.4483
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4423
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4423
Small cell lung cancer_Homo sapiens_hsa05222 BCL2 0.4423
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4423
Peroxisome_Homo sapiens_hsa04146 XDH 0.4483
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4423
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.4851
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.6696
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4789
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4915
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5068
Glioma_Homo sapiens_hsa05214 IGF1R 0.5068
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5054
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5068
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2 0.4927
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.5068
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.6863
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.5068
Shigellosis_Homo sapiens_hsa05131 SRC 0.5068
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.5496
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3 0.5444
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.6381
Malaria_Homo sapiens_hsa05144 MET 0.5804
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8601
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6007
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.6087
Cysteine and methionine metabolism_Homo sapiens_hsa00270 DNMT1 0.6047
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.633
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.6702
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7033
Base excision repair_Homo sapiens_hsa03410 APEX1 0.6887
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7488
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7113
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7447
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 FDPS 0.8047
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9496
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 2.9566


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)