TCM Prescription: Wu Mei Pills



Prescription Description
Prescription IDTCMF5269
Pinyin NameWu Mei Wan
Chinese Name乌梅丸
English NameWu Mei Pills
Function Description蛔虫病, 痢疾, 头痛, 胃脘痛
IndicationsStomach ache disorder, Dysentery disorder, Ascariasis, Dysentery, Headache
Disease ICD-11 Category SA51 [Stomach ache disorder (TM1), 胃脘痛 (TM1) ];
SA56 [Dysentery disorder (TM1), 痢疾 (TM1) ];
1F62 [Ascariasis, 蛔虫病 ];
1A40.Z [Infectious gastroenteritis or colitis without specification of infectious agent, 未特指感染性病原体的感染性胃肠炎或结肠炎 ];
MB6Y [Other specified symptoms or signs involving the nervous system, 其他特指的累及神经系统的症状或体征 ];
Human Tissues Associated with IndicationIntestine, Stomach
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2191 Prunus mume 乌梅 TCMH2191 ITSAN1052-14
TCMH924 Zanthoxylum bungeanum 花椒 TCMH924 ITSAJ4650-14
TCMH2239 Asarum sieboldii 细辛 TCMH2239 ITSAI1576-14
TCMH972 Coptis chinensis 黄连 TCMH972 ITSAO4469-14
TCMH949 Phellodendron amurense 黄柏 TCMH949 ITSAM1586-14
TCMH1059 Glycine max 姜 TCMH1059 ITSAJ4675-14
TCMH623 Aconitum carmichaeli 附子 TCMH623 ITSAH2410-14
TCMH761 Cinnamomum cassia 桂枝 TCMH761 GQ255631
TCMH1721 Panax ginseng 人参 TCMH1721 GBVE1679-11
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT197 PDE4D Phosphodiesterase 4D Hydrolase Q08499
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT220 CYP2J2 Cytochrome P450 2J2 Oxidoreductase P51589
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT287 TAS2R31 Taste receptor type 2 member 31 GPCR P59538
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT407 MYLK Myosin light chain kinase, smooth muscle Kinase Q15746
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT601 F2 Thrombin Unclassified P00734
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT675 ADRB1 Beta-1 adrenergic receptor GPCR P08588
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT698 PDE4B Phosphodiesterase 4B Hydrolase Q07343
TCMT704 ERBB2 Receptor protein-tyrosine kinase erbB-2 Kinase P04626
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT778 KCNA5 Voltage-gated potassium channel subunit Kv1.5 Ion channel P22460
TCMT780 CACNA1D Voltage-gated L-type calcium channel alpha-1D subunit Ion channel Q01668
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT848 ERN1 Serine/threonine-protein kinase/endoribonuclease IRE1 Kinase O75460
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1172 Staphylococcus aureus subsp. aureus RN4220
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1292 Japanese encephalitis virus
TCMT1294 Human parainfluenza virus 3
TCMT1305 Salmonella enteritidis
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1336 Yellow fever virus
TCMT1337 Dengue virus type 4
TCMT1338 Rift Valley fever virus
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1385 Candida shehatae
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 13.627
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 12.6877
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD2, EGFR, ERBB2, ESR1, FABP3, FABP4, HSD17B1, HSD17B2, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 11.9883
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, BCL2, CA3, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, ESRRA, FABP3, HSD17B2, IGF1R, MMP2, MMP9, PIK3CA, PPARA, PTGS2, SRC, TYR 11.3883
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 11.2602
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, FABP3, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TYR, XDH 10.1997
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, AXL, BCL2, CA2, CA3, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, PIK3CA, PPARA, PTGS2, SRC, TYR 10.1997
[BP] GO:0008152 metabolic process ACHE, ADORA1, ADRB1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, SRC, TYR, XDH 9.40609
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRB1, AKR1B1, AURKB, AXL, BCL2, CA12, CA2, CA7, CACNA1C, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, DRD3, EGFR, ESR1, F2, F3, FABP3, FABP4, FLT3, HCAR2, HSD17B1, HSD17B2, KDR, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SRC, XDH 9.24788
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CACNA1C, CNR1, DRD1, DRD2, DRD3, EGFR, F2, HCAR2, KDR, PIK3CB, PTGS2, SRC 9.04437
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRB1, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, F2, F3, FLT3, HCAR2, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 9.04437
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRB1, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, F2, F3, FLT3, HCAR2, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 9.02167
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD2, EGFR, ERBB2, FABP3, FABP4, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 8.79922
[BP] GO:0042221 response to chemical AKR1B1, ALPL, AXL, BCL2, CA2, CA3, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, MMP9, PIK3CA, PPARA, PTGS2, SRC, TYR 8.64746
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD17B2, PTGS2, SRC, TYR 8.29009
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, SRC, TYR, XDH 8.26908
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, ESRRA, FLT3, PTGS2, SRC, TYR 8.26908
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 7.93961
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, FABP3, PPARA 7.89879
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, CNR1, DRD1, DRD2, DRD3, EGFR, F2, HCAR2, PIK3CB, PTGS2 7.75968
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, BCL2, CDC25B, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESRRA, F2, F3, FABP3, FLT3, IGF1R, KDR, MMP2, MMP9, PIM1, PTGS1, PTGS2, SRC, XDH 7.72326
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 7.42821
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, ESR1, HSD17B1, HSD17B2 7.37792
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRB1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CACNA1C, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, F2, F3, FLT3, HCAR2, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 7.29284
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 7.18369
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRB1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CACNA1C, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, F2, F3, FLT3, HCAR2, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 7.15979
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRB1, AKR1B1, AXL, BCL2, CYP1B1, DRD2, EGFR, ERBB2, F2, F3, FLT3, KDR, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 7.15616
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CA3, CNR1, CNR2, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, KDR, SRC 7.15616
[BP] GO:0042592 homeostatic process ADORA1, ADRB1, AKR1B1, AXL, BCL2, CA12, CA2, CA7, CACNA1C, CNR1, DRD1, DRD2, DRD3, EGFR, ESR1, F2, FABP3, FABP4, FLT3, MET, PIK3CA, PIK3CB, SRC 7.05385
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, F2, KDR, SRC 7.0294
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, HCAR2, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, XDH 7.0294
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, DRD3, EGFR, ERBB2, F3, MET, PIK3CA, PIK3CB, SRC, XDH 6.99543
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 6.97736
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, HCAR2, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, XDH 6.95475
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CACNA1C, CNR1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, EGFR, ESR1, HCAR2, HSD17B1, HSD17B2 6.91507
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRB1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, ERBB2, ESR1, F2, F3, FLT3, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 6.89834
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRB1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FLT3, HCAR2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, XDH 6.86559
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ERBB2, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, KDR, PIK3CA, PPARA, SRC, TYR 6.6093
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CA3, CA9, CNR1, CNR2, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, FABP3, KDR, PTGS2, SRC 6.56639
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, FABP3, PPARA 6.54302
[BP] GO:0010035 response to inorganic substance AKR1B1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP4, KDR, MMP9, PTGS2, SRC 6.49043
[BP] GO:0032501 multicellular organismal process ADORA1, ADRB1, AKR1B1, AKR1B10, ALOX5, ALPL, AXL, BCL2, CACNA1C, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, ESRRB, F2, F3, FABP4, HSD17B2, IGF1R, MET, MMP1, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, SRC, TYR 6.49043
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CA3, CA6, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESRRA, F2, F3, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, SRC, TYR 6.48964
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRB1, BCL2, CDC25B, DRD1, DRD2, EGFR, ERBB2, ESRRB, F2, FABP3, FLT3, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 6.39329
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRB1, BCL2, CDC25B, DRD1, DRD2, EGFR, ERBB2, ESRRB, F2, FABP3, FLT3, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 6.39329
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DRD1, EGFR, ERBB2, ESR1, ESRRA, FABP3, FLT3, IGF1R, MMP2, PPARA, PTGS2, SRC 6.39056
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, HCAR2, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, XDH 6.3427
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, CNR1, CNR2, DRD2 6.32222
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRB1, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, ERBB2, F2, F3, FLT3, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 6.30506
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CSNK2A1, DRD2, DRD3, EGFR, ERBB2, ESR1, F2, F3, FLT3, IGF1R, KDR, MMP2, MMP9, PIM1, PTGS2 6.29222
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 6.0936
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRB1, AKR1B1, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, ERBB2, ESRRA, F2, F3, FABP4, FLT3, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 6.05717
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRB1, BCL2, CDC25B, DRD1, DRD2, DRD3, EGFR, ERBB2, ESRRB, F2, FABP3, FABP4, FLT3, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 5.93415
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 5.89604
[BP] GO:0048878 chemical homeostasis AKR1B1, BCL2, CA12, CA2, CA7, CACNA1C, CNR1, DRD1, DRD2, DRD3, EGFR, ESR1, F2, FABP3, FABP4, MET, PIK3CA, PIK3CB 5.89604
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRB1, BCL2, CDC25B, DRD1, DRD2, DRD3, EGFR, ERBB2, ESRRB, F2, FABP3, FABP4, FLT3, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 5.88694
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, EGFR 5.87015
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 5.87015
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.85704
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.85704
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRB1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, HCAR2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, XDH 5.82917
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, CYP3A4, NQO2, PTGS1 5.70375
[BP] GO:0045776 None ADORA1, ADRB1, CNR1, DRD2, DRD3, PPARA 5.67627
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PPARA, PTGS1, PTGS2 5.67243
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRB1, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, F2, F3, FABP4, FLT3, IGF1R, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, XDH 5.67243
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, AXL, BCL2, CA2, CA7, CACNA1C, CNR1, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, F2, F3, HCAR2, IGF1R, KDR, MET, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SRC 5.63879
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRB1, AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CA9, CACNA1C, CDC25B, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, ERBB2, ESR1, ESRRA, ESRRB, F2, FABP4, FLT3, HSD17B2, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, SRC, TYR 5.62727
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRB1, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, F2, F3, FABP4, FLT3, IGF1R, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.62707
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, PTGS2 5.62707
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, PTGS2 5.62707
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.62707
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, PPARA, PTGS2, SRC 5.61639
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 5.52669
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, BCL2, CACNA1C, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, ERBB2, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 5.51333
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CNR1, CNR2, CYP19A1, DRD1, DRD2, DRD3, EGFR, ESR1, F2, F3, FABP4, KDR, MET, PPARA, PTGS2 5.4911
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, DRD2, EGFR, ERBB2, F2, PPARA 5.45891
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, CYP2D6, DRD2, DRD3, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC 5.36559
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 5.34593
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 5.30763
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, ERBB2, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 5.21455
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SRC 5.14772
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, PIM1, SRC 5.14587
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, BCL2, CNR1, CNR2, CYP19A1, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, F2, IGF1R, MET, MMP9, PPARA, PTGS2, PTPN1, SRC, XDH 5.14587
[BP] GO:0042325 regulation of phosphorylation ADORA1, BCL2, CDC25B, DRD1, DRD2, EGFR, ERBB2, ESRRB, F2, FABP4, FLT3, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 5.05978
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, AXL, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, ERBB2, ESR1, ESRRA, ESRRB, F2, FLT3, HSD17B2, KDR, MMP9, PIK3CA, PIM1, PPARA, PTGS2, SRC, TYR 4.98051
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, BCL2, CDC25B, DRD2, EGFR, ERBB2, ESRRB, F2, FLT3, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.92096
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SRC 4.91583
[BP] GO:0008217 None ADORA1, ADRB1, CNR1, DRD2, DRD3, PPARA, PTGS1, PTGS2 4.9109
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, CNR1, DRD1, DRD2, EGFR, PTGS2 4.8821
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CNR1, CYP1A1, DRD3, F2, FABP3, FLT3, HCAR2, PPARA, PTGS2, SRC 4.88095
[BP] GO:0010243 response to organonitrogen compound AKR1B1, CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, FABP3, FLT3, IGF1R, MMP2, PPARA, PTGS2, SRC, TYR 4.87677
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRB1, AKR1B1, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, F2, F3, FABP4, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 4.86203
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, ERBB2, F3, MET, PIK3CA, PIK3CB, SRC 4.86203
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 4.79919
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRB1, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 4.71594
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, CNR2, DRD1, DRD2, PTGS2 4.69236
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, EGFR 4.68665
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.50271
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ERBB2, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, PIK3CA, PTGS2, SRC 4.49667
[BP] GO:1901698 response to nitrogen compound AKR1B1, CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, FABP3, FLT3, IGF1R, MMP2, PPARA, PTGS2, SRC, TYR 4.47521
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, AURKB, AXL, BCL2, CA3, CDC25B, CSNK2A1, DRD1, DRD2, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, XDH 4.46505
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, BCL2, CDC25B, DRD2, EGFR, ERBB2, F2, FLT3, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.4606
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, DRD1, EGFR, ERBB2, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, PIK3CA, PTGS2, SRC 4.42555
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, ADRB1, AKR1B1, DRD1, DRD2, MET, PIK3CA 4.41822
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRB1, AURKB, BCL2, CDC25B, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FLT3, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 4.39234
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, DRD3, TYR 4.36264
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, CA2, CA7, DRD1, DRD2, EGFR, PTGS2 4.35339
[BP] GO:0032225 None DRD1, DRD2, DRD3, PTGS2 4.35077
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, BCL2, CDC25B, DRD1, DRD2, EGFR, ERBB2, F2, FABP4, FLT3, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.33653
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, IGF1R, KDR, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SRC 4.2858
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, EGFR 4.27278
[BP] GO:0051049 regulation of transport ACHE, ADORA1, AXL, BCL2, CA2, CA7, CACNA1C, CNR1, CYP19A1, DRD1, DRD2, DRD3, EGFR, ERBB2, F2, HCAR2, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SRC 4.26687
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRB1, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FLT3, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 4.26042
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, SRC 4.26042
[BP] GO:0018958 None AKR1B1, BCL2, DRD1, DRD2, DRD3, TYR 4.23981
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, SRC 4.21353
[BP] GO:0006979 response to oxidative stress AKR1B1, AXL, BCL2, CA3, CYP1B1, EGFR, MMP9, PTGS1, PTGS2, SRC 4.20137
[BP] GO:0009628 response to abiotic stimulus ADORA1, ADRB1, AKR1B1, AURKB, BCL2, CA2, CYP1A1, DRD1, DRD2, DRD3, EGFR, MMP2, PPARA, PTGS2, SRC, TYR 4.17547
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CDC25B, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, HCAR2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, SRC, TYR, XDH 4.17547
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, AURKB, AXL, BCL2, CA3, CDC25B, CSNK2A1, DRD1, DRD2, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, XDH 4.17025
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, CNR2, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 4.14185
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, AXL, BCL2, CA2, CA3, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, ERBB2, F2, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, SRC 4.12796
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, CNR2, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 4.12786
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, EGFR, ERBB2, ESR1, FLT3, MET, PIK3CB, PIM1, SRC, TYR 4.10018
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SRC, XDH 4.09093
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRB1, AKR1B1, AXL, BCL2, CA1, CA2, CACNA1C, CNR1, CNR2, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HCAR2, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTPN1, SRC 4.09093
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 4.05519
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, HCAR2, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SRC, XDH 4.01038
[BP] GO:0050801 ion homeostasis BCL2, CA12, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, EGFR, ESR1, F2, FABP3, PIK3CB 4.00615
[BP] GO:0031347 regulation of defense response ADORA1, CNR1, CNR2, CYP19A1, DRD2, EGFR, ESR1, F2, FABP4, MMP2, PPARA, PTGS2, PTPN1, SRC 4.00009
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, CNR1, DRD2, DRD3, MMP9, PTGS2 3.9813
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 3.98067
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD2, DRD3, EGFR, ESR1, PPARA, SRC 3.95281
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2D6, CYP3A4 3.92535
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRB1, AXL, BCL2, CA2, CACNA1C, CNR1, CYP1B1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESRRA, ESRRB, F2, F3, HCAR2, KDR, MET, MMP9, PIK3CA, PIM1, PTGS2, SRC, XDH 3.89142
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 3.87167
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIK3CA, PIM1, SRC 3.87167
[BP] GO:0090087 None ACHE, ADORA1, CA2, CACNA1C, CNR1, DRD2, DRD3, EGFR, ERBB2, F2, HCAR2, PTGS2, PTPN1, SRC 3.8653
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PPARA, PTGS1, PTGS2 3.84652
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, FABP3, FABP4, MMP1, MMP2, MMP9, PIK3CB, SRC, XDH 3.81113
[BP] GO:0050727 regulation of inflammatory response ADORA1, CNR1, CNR2, CYP19A1, EGFR, ESR1, F2, FABP4, PPARA, PTGS2 3.79118
[BP] GO:0051240 positive regulation of multicellular organismal process ADRB1, AXL, BCL2, CA2, CNR1, CYP1B1, DRD2, DRD3, EGFR, ESRRB, F2, F3, HCAR2, KDR, MET, MMP9, PIM1, PTGS2, SRC 3.74077
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, AXL, BCL2, CA2, CYP19A1, DRD1, DRD2, DRD3, EGFR, ERBB2, F2, HCAR2, PTGS2, SRC 3.73316
[BP] GO:0009820 alkaloid metabolic process CYP1A2, CYP2D6, CYP3A4 3.7117
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.71086
[BP] GO:0043269 regulation of ion transport ADORA1, BCL2, CA2, CA7, CACNA1C, CNR1, DRD1, DRD2, DRD3, F2, MMP9, PTGS2 3.68566
[BP] GO:0046486 glycerolipid metabolic process ACHE, CSNK2A1, DRD2, EGFR, ERBB2, FABP3, FABP4, MET, PIK3CA, PIK3CB 3.65775
[BP] GO:0010038 response to metal ion BCL2, CA2, CYP1A1, CYP1A2, DRD2, EGFR, FABP4, MMP9, PTGS2 3.59056
[BP] GO:0001975 None CNR2, DRD1, DRD2, DRD3 3.58685
[BP] GO:0044093 positive regulation of molecular function ADORA1, ADRB1, AURKB, BCL2, CDC25B, DRD2, EGFR, ERBB2, ESR1, ESR2, F2, F3, FLT3, MET, MMP9, PIK3CA, PIK3CB, PTPN1, SRC, XDH 3.57049
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DRD2, DRD3, ESR1, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 3.57049
[BP] GO:0051940 None DRD1, DRD2, DRD3 3.54629
[BP] GO:0051584 None DRD1, DRD2, DRD3 3.54629
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 3.53643
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD17B1, HSD17B2 3.51758
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC 3.50901
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, DRD1, DRD2, DRD3, FABP3, PPARA 3.4887
[BP] GO:0098771 inorganic ion homeostasis BCL2, CA12, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, EGFR, ESR1, F2, PIK3CB 3.48035
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC 3.46402
[BP] GO:0080134 regulation of response to stress ADORA1, CNR1, CNR2, CYP19A1, DRD2, EGFR, ESR1, F2, F3, FABP4, IGF1R, MET, MMP2, PPARA, PTGS2, PTPN1, SRC, XDH 3.45796
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, BCL2, CDC25B, CSNK2A1, DRD2, EGFR, ERBB2, ESR1, F2, F3, FLT3, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.45796
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, SRC 3.45396
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, DRD2, EGFR, ERBB2, F2, FLT3, PIK3CA, PIK3CB, PTPN1, SRC 3.36762
[BP] GO:0030335 positive regulation of cell migration BCL2, DRD1, EGFR, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 3.36762
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2, DRD3 3.35807
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, DRD2, MMP2, PPARA, PTGS2, SRC 3.35509
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRB1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, F2, F3, FLT3, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.35244
[BP] GO:0040014 regulation of multicellular organism growth ADRB1, BCL2, DRD2, DRD3, PIK3CA 3.35244
[BP] GO:0007187 None ADORA1, ADRB1, CNR1, CNR2, DRD1, DRD2, DRD3 3.35049
[BP] GO:0001659 None ADORA1, ADRB1, DRD1, DRD2 3.33773
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling ERBB2, IGF1R, PIK3CA, PIK3CB 3.33773
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, CYP1A1, CYP1B1, DRD1, EGFR, ESR1, FLT3, PTGS2, SRC 3.32505
[BP] GO:0009895 negative regulation of catabolic process ADORA1, BCL2, CNR1, EGFR, HCAR2, MET, PIK3CA, PPARA 3.3221
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AXL, BCL2, CDC25B, CNR1, CYP19A1, CYP1A1, DRD1, EGFR, ESR1, ESRRB, HSD17B2, MMP2, MMP9, PTGS2, SRC 3.30139
[BP] GO:0031401 positive regulation of protein modification process ADORA1, BCL2, CDC25B, DRD2, EGFR, ERBB2, F2, FLT3, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.30077
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.28611
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, DRD2, MMP2, PPARA, PTGS2, SRC 3.28556
[BP] GO:0009892 negative regulation of metabolic process ADORA1, AURKB, BCL2, CNR1, CNR2, CSNK2A1, CYP2D6, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, F2, FABP4, HCAR2, IGF1R, KDR, MET, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, SRC, XDH 3.28503
[BP] GO:0045834 positive regulation of lipid metabolic process F2, FABP3, FLT3, PPARA, PTGS2, SRC 3.27815
[BP] GO:2000147 positive regulation of cell motility BCL2, DRD1, EGFR, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 3.27098
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, SRC, TYR, XDH 3.26773
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 3.25942
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, DRD2, EGFR, ERBB2, F2, FLT3, PIK3CA, PIK3CB, PTPN1, SRC 3.25935
[BP] GO:0035556 intracellular signal transduction ADRB1, AKR1B1, AXL, BCL2, CACNA1C, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, IGF1R, KDR, MET, PIK3CA, PIK3CB, PTPN1, SRC 3.25639
[BP] GO:0002682 regulation of immune system process ADORA1, AXL, BCL2, CA2, CNR1, CNR2, CYP19A1, DRD2, ERBB2, ESR1, ESRRA, F2, HCAR2, MMP2, PIK3CA, PIK3CB, PTPN1, SRC 3.25429
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, BCL2, CDC25B, DRD2, EGFR, ERBB2, ESR1, F2, F3, FLT3, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.2443
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 3.23984
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, PTGS2, SRC 3.18913
[BP] GO:0070201 None ACHE, BCL2, CACNA1C, CNR1, DRD2, DRD3, EGFR, ERBB2, F2, HCAR2, PTGS2, PTPN1, SRC 3.18464
[BP] GO:0051272 positive regulation of cellular component movement BCL2, DRD1, EGFR, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 3.18464
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CNR2, CYP19A1, DRD1, DRD2, DRD3, F2, PPARA 3.17712
[BP] GO:0032103 positive regulation of response to external stimulus CNR1, EGFR, F2, F3, FABP4, KDR, MET, PTGS2 3.17712
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, EGFR 3.17072
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 3.17072
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, DRD1, EGFR, KDR, PTGS2, SRC 3.14852
[BP] GO:0051952 None ADORA1, CNR1, DRD1, DRD2, DRD3 3.14545
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2 3.14545
[BP] GO:0016477 cell migration AXL, CNR2, CYP1B1, DRD1, DRD2, EGFR, F2, KDR, MMP1, MMP9, PIK3CA, PIK3CB, SRC 3.13995
[BP] GO:0009416 response to light stimulus AURKB, BCL2, DRD1, DRD2, DRD3, EGFR, PTGS2, TYR 3.122
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRB1, AURKB, BCL2, CDC25B, DRD2, EGFR, ERBB2, ESR1, F2, F3, FLT3, PIK3CA, PIK3CB, PTPN1, SRC, XDH 3.0863
[BP] GO:0032467 None AURKB, CDC25B, DRD2, DRD3 3.0863
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ERBB2, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, PIK3CA, PTGS2, PTPN1, SRC 3.0863
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, PTGS2, SRC 3.08264
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP3A4 3.08264
[BP] GO:0070989 oxidative demethylation CYP1A2, CYP2D6, CYP3A4 3.08264
[BP] GO:0040017 positive regulation of locomotion BCL2, DRD1, EGFR, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 3.08231
[BP] GO:0043549 regulation of kinase activity ADORA1, CDC25B, DRD2, EGFR, ERBB2, F2, FABP4, FLT3, IGF1R, PIK3CA, PIK3CB, PTPN1, SRC 3.08147
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, DRD2, MMP2, PPARA, PTGS2, SRC 3.07482
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, SRC, TYR, XDH 3.06116
[BP] GO:0014075 None CNR2, DRD1, DRD2, DRD3 3.05688
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PIM1, PPARA, PTGS1, PTGS2, TYR 3.03553
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, PTGS2, SRC 3.02934
[BP] GO:0031399 regulation of protein modification process ADORA1, BCL2, CDC25B, DRD1, DRD2, EGFR, ERBB2, F2, FABP4, FLT3, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.01922
[BP] GO:0038128 None EGFR, ERBB2, PIK3CA, SRC 3.01922
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, PTGS2, TYR 3.01856
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.99437
[BP] GO:0060134 None DRD1, DRD2, DRD3 2.99437
[BP] GO:0009115 None AOX1, XDH 2.99239
[BP] GO:0051338 regulation of transferase activity ADORA1, AURKB, CDC25B, DRD2, EGFR, ERBB2, F2, FABP4, FLT3, IGF1R, PIK3CA, PIK3CB, PTPN1, SRC 2.95855
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DRD1, EGFR, ERBB2, F2, FLT3, IGF1R, KDR, MET, SRC 2.95855
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, EGFR, FLT3, PTGS2, SRC 2.95664
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, DRD2, EGFR, ERBB2, FLT3, KDR, PIK3CB, PTPN1, SRC, XDH 2.94676
[BP] GO:0009410 None CNR1, CNR2, DRD1, DRD2, DRD3, EGFR 2.94472
[BP] GO:0055080 cation homeostasis BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, EGFR, ESR1, F2, PIK3CB 2.93763
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CYP1B1, DRD1, EGFR, ESR1, IGF1R, MMP2, MMP9, PIK3CA, PTGS2, SRC 2.93094
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, DRD2, EGFR, ERBB2, FLT3, PIK3CA, PIK3CB, PTPN1, SRC 2.93094
[BP] GO:0040011 locomotion AXL, CNR2, CYP1B1, DRD1, DRD2, EGFR, F2, KDR, MET, MMP1, MMP9, PIK3CA, PIK3CB, SRC 2.92704
[BP] GO:0009891 positive regulation of biosynthetic process ADRB1, AURKB, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, IGF1R, KDR, MET, PPARA, PTGS2, SRC 2.9202
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.9202
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.91999
[BP] GO:0051580 None DRD1, DRD2, DRD3 2.91999
[BP] GO:0032880 regulation of protein localization ACHE, BCL2, CACNA1C, CNR1, CSNK2A1, DRD2, DRD3, EGFR, ERBB2, F2, HCAR2, PTGS2, PTPN1, SRC 2.91561
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, BCL2, CA1, CSNK2A1, DRD2, EGFR, ERBB2, F2, F3, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 2.91005
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, DRD3 2.88929
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, DRD3 2.88929
[BP] GO:2001023 None CNR1, DRD1, DRD2, DRD3, MET 2.88627
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, F2, F3, FLT3, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SRC, TYR, XDH 2.86034
[BP] GO:0072507 divalent inorganic cation homeostasis BCL2, CACNA1C, DRD1, DRD2, DRD3, EGFR, ESR1, F2, PIK3CB 2.853
[BP] GO:0001963 None DRD1, DRD2, DRD3 2.83739
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, PTGS2, SRC 2.82541
[BP] GO:0003018 None ADORA1, ADRB1, DRD1, EGFR, PTGS2, SRC 2.82541
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC 2.82285
[BP] GO:0097366 None CNR2, DRD1, DRD2, DRD3 2.82285
[BP] GO:0007188 None ADORA1, ADRB1, CNR1, DRD1, DRD2, DRD3 2.81461
[BP] GO:0040008 regulation of growth ADRB1, BCL2, CSNK2A1, DRD2, DRD3, EGFR, ERBB2, ESR2, F2, PIK3CA, PIM1 2.81461
[BP] GO:0055082 cellular chemical homeostasis BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, ESR1, F2, PIK3CA, PIK3CB 2.81461
[BP] GO:0009894 regulation of catabolic process ADORA1, BCL2, CNR1, CSNK2A1, EGFR, ESRRB, HCAR2, KDR, MET, PIK3CA, PIK3CB, PPARA, PTPN1 2.81108
[BP] GO:0051223 None ACHE, CACNA1C, CNR1, DRD2, DRD3, EGFR, ERBB2, F2, HCAR2, PTGS2, PTPN1, SRC 2.80285
[BP] GO:0019932 second-messenger-mediated signaling ADRB1, CACNA1C, DRD1, DRD2, DRD3, EGFR, KDR 2.80175
[BP] GO:0048870 cell motility AXL, CNR2, CYP1B1, DRD1, DRD2, EGFR, F2, KDR, MMP1, MMP9, PIK3CA, PIK3CB, SRC 2.80039
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRB1, AURKB, BCL2, CA9, CDC25B, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, HCAR2, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, XDH 2.79109
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MMP9, PTGS2, PTPN1, SRC 2.77288
[BP] GO:0045859 regulation of protein kinase activity ADORA1, CDC25B, DRD2, EGFR, ERBB2, FABP4, FLT3, IGF1R, PIK3CA, PIK3CB, PTPN1, SRC 2.77178
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.77084
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.77084
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CNR1, CYP1A1, EGFR, PTGS2, SRC, TYR 2.76658
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, KDR, SRC 2.76658
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, AXL, CNR2, F2, PIK3CA, PIK3CB, PTGS1, PTGS2 2.74489
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 2.74214
[BP] GO:0030258 lipid modification CYP1A1, CYP3A4, EGFR, ERBB2, MET, PIK3CA, PIK3CB 2.7237
[BP] GO:0006650 glycerophospholipid metabolic process ACHE, CSNK2A1, DRD2, EGFR, ERBB2, MET, PIK3CA, PIK3CB 2.71645
[BP] GO:0046854 phosphatidylinositol phosphorylation EGFR, ERBB2, MET, PIK3CA, PIK3CB 2.70123
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, EGFR, ERBB2, FLT3, IGF1R, PIK3CB, PTPN1, SRC 2.68389
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.6759
[BP] GO:0043436 oxoacid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PIM1, PPARA, PTGS1, PTGS2, TYR 2.67185
[BP] GO:0050793 regulation of developmental process ADRB1, AXL, BCL2, CA2, CNR1, CYP1B1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESRRA, ESRRB, F2, F3, KDR, PIK3CA, PIM1, PPARA, PTGS2, SRC, XDH 2.67162
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, F2, PTGS2, XDH 2.65084
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 2.64667
[BP] GO:0002791 None ACHE, ADORA1, CACNA1C, CNR1, DRD2, DRD3, EGFR, HCAR2, SRC 2.63153
[BP] GO:0030003 cellular cation homeostasis BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, ESR1, F2, PIK3CB 2.63153
[BP] GO:0031348 negative regulation of defense response ADORA1, CNR2, CYP19A1, DRD2, F2, PPARA 2.62742
[BP] GO:0071241 cellular response to inorganic substance CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.61453
[BP] GO:0050994 None ADORA1, CNR1, HCAR2, PPARA 2.61383
[BP] GO:0045927 positive regulation of growth BCL2, CSNK2A1, DRD2, EGFR, ERBB2, F2, PIM1 2.61288
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, DRD3, EGFR, PTGS2 2.61288
[BP] GO:0006082 organic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PIM1, PPARA, PTGS1, PTGS2, TYR 2.61288
[BP] GO:0009822 alkaloid catabolic process CYP2D6, CYP3A4 2.61288
[BP] GO:0046110 None AOX1, XDH 2.61288
[BP] GO:0060160 None DRD2, DRD3 2.61288
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.61288
[BP] GO:0033602 None CNR1, DRD2 2.61288
[BP] GO:0010959 None ADORA1, BCL2, CACNA1C, DRD1, DRD2, DRD3, F2, PTGS2 2.57939
[BP] GO:0045187 None ADORA1, DRD2, DRD3 2.5791
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.5791
[BP] GO:0006873 cellular ion homeostasis BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, ESR1, F2, PIK3CB 2.56503
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.55412
[BP] GO:0046883 regulation of hormone secretion ADORA1, CACNA1C, CNR1, CYP19A1, DRD2, EGFR, HCAR2 2.54631
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, ERBB2, FLT3, PIK3CB, PTPN1, SRC 2.5371
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, ADRB1, CA2, CNR1, CNR2, DRD1, DRD2, DRD3, ESR1, F2, HCAR2, PIK3CA, PIK3CB, SRC 2.52823
[BP] GO:0030168 platelet activation AXL, F2, PIK3CA, PIK3CB, SRC 2.52329
[BP] GO:0048148 None DRD1, DRD2, DRD3 2.52188
[BP] GO:0035813 None ADORA1, DRD2, DRD3 2.52188
[BP] GO:0046834 lipid phosphorylation EGFR, ERBB2, MET, PIK3CA, PIK3CB 2.5093
[BP] GO:0043408 regulation of MAPK cascade ADORA1, DRD2, EGFR, ERBB2, FLT3, IGF1R, KDR, PIK3CB, PTPN1, SRC, XDH 2.5093
[BP] GO:0050890 None ADORA1, CNR1, DRD1, DRD2, DRD3, EGFR, PTGS2 2.46492
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.46443
[BP] GO:0051968 None DRD1, EGFR, PTGS2 2.46443
[BP] GO:0042749 None ADORA1, DRD2, DRD3 2.46443
[BP] GO:0042737 drug catabolic process ACHE, CYP1A2, CYP2A6, CYP2D6, CYP3A4 2.46231
[BP] GO:0001503 ossification ALPL, BCL2, EGFR, MMP2, MMP9 2.46231
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CNR2, CYP19A1, F2, PPARA 2.4454
[BP] GO:0070988 demethylation CYP1A1, CYP1A2, CYP2D6, CYP3A4 2.43957
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CNR1, CYP1B1, F3, HCAR2, MMP9, PIK3CB, PTGS2, SRC, XDH 2.42621
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.41125
[BP] GO:0050995 None ADORA1, CNR1, HCAR2 2.41125
[BP] GO:0006874 cellular calcium ion homeostasis BCL2, CACNA1C, DRD1, DRD2, DRD3, ESR1, F2, PIK3CB 2.39856
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CNR1, CYP1B1, F3, HCAR2, MMP9, PIK3CB, PTGS2, SRC, XDH 2.39649
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, EGFR, HCAR2, SRC 2.39291
[BP] GO:0048015 phosphatidylinositol-mediated signaling ERBB2, IGF1R, PIK3CA, PIK3CB 2.39291
[BP] GO:0007584 response to nutrient ALPL, CNR1, CYP1A1, EGFR, PTGS2, TYR 2.3919
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, EGFR, ESR1, MET, SRC 2.38851
[BP] GO:0060341 regulation of cellular localization BCL2, CACNA1C, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ERBB2, F2, PTGS2, PTPN1, SRC 2.38364
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 2.38289
[BP] GO:0051953 None ADORA1, CNR1, DRD2 2.37246
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.37246
[BP] GO:0044062 None ADORA1, DRD2, DRD3 2.37246
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.37246
[BP] GO:1903522 None ADORA1, ADORA3, ADRB1, CACNA1C, DRD2, EGFR, PTGS2 2.37246
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.37246
[BP] GO:0006145 None AOX1, XDH 2.37246
[BP] GO:0038171 None CNR1, CNR2 2.37246
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.37246
[BP] GO:0009968 negative regulation of signal transduction BCL2, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 2.37246
[BP] GO:0050795 None ADORA1, CNR1, DRD2, DRD3 2.33217
[BP] GO:0048017 inositol lipid-mediated signaling ERBB2, IGF1R, PIK3CA, PIK3CB 2.33217
[BP] GO:0055074 calcium ion homeostasis BCL2, CACNA1C, DRD1, DRD2, DRD3, ESR1, F2, PIK3CB 2.33048
[BP] GO:0097746 None ADORA1, ADRB1, DRD1, EGFR, PTGS2 2.32717
[BP] GO:0035296 None ADORA1, ADRB1, DRD1, EGFR, PTGS2 2.32717
[BP] GO:0032355 response to estradiol CYP1A2, EGFR, ESR1, ESRRA, PTGS2 2.32717
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.32717
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC 2.31263
[BP] GO:0072503 cellular divalent inorganic cation homeostasis BCL2, CACNA1C, DRD1, DRD2, DRD3, ESR1, F2, PIK3CB 2.29885
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD17B1, HSD17B2 2.2984
[BP] GO:0046488 phosphatidylinositol metabolic process DRD2, EGFR, ERBB2, MET, PIK3CA, PIK3CB 2.28888
[BP] GO:0042391 None ADORA1, BCL2, CACNA1C, CNR1, CNR2, DRD1, KDR, SRC 2.28697
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, BCL2, DRD2, EGFR, ERBB2, F2, HCAR2, PTGS2, SRC 2.2866
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AOX1, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, FABP3, FABP4, PIK3CB, SRC, XDH 2.28436
[BP] GO:0003013 None ADORA1, ADRB1, DRD1, EGFR, PTGS2, SRC 2.2825
[BP] GO:0043393 regulation of protein binding AURKB, BCL2, MET, MMP9, PPARA, SRC 2.2825
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2 2.27349
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, F3, MMP9, PTGS2, SRC, XDH 2.27299
[BP] GO:0015908 None DRD2, DRD3, FABP3, PPARA 2.27238
[BP] GO:0044057 None ADORA1, ADORA3, ADRB1, CACNA1C, DRD2, DRD3, EGFR, HCAR2, PTGS2 2.26846
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CNR1, CYP1A1, EGFR, PTGS2, SRC, TYR 2.2591
[BP] GO:0032465 None AURKB, CDC25B, DRD2, DRD3 2.25035
[BP] GO:0006928 movement of cell or subcellular component AXL, CNR2, CYP1B1, DRD1, DRD2, EGFR, ERBB2, F2, KDR, MMP1, MMP9, PIK3CA, PIK3CB, PTGS2, SRC 2.25001
[BP] GO:0003008 None ADORA1, ADRB1, AKR1B1, BCL2, CNR1, CNR2, CYP1B1, DRD1, DRD2, DRD3, EGFR, PIK3CA, PTGS2, SRC, TYR 2.24062
[BP] GO:2000026 regulation of multicellular organismal development AXL, BCL2, CA2, CNR1, CYP1B1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESRRA, F2, F3, KDR, PIM1, PTGS2, SRC, XDH 2.24062
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.24062
[BP] GO:0006644 phospholipid metabolic process ACHE, CSNK2A1, DRD2, EGFR, ERBB2, MET, PIK3CA, PIK3CB 2.23583
[BP] GO:0019725 cellular homeostasis BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, ESR1, F2, PIK3CA, PIK3CB 2.22387
[BP] GO:0050880 None ADORA1, ADRB1, DRD1, EGFR, PTGS2 2.22288
[BP] GO:0009411 response to UV AURKB, BCL2, EGFR, PTGS2, TYR 2.20949
[BP] GO:0035150 None ADORA1, ADRB1, DRD1, EGFR, PTGS2 2.20949
[BP] GO:0045745 None DRD2, DRD3, F2 2.19671
[BP] GO:0021853 None DRD1, DRD2 2.19345
[BP] GO:0010641 None F3, SRC 2.19345
[BP] GO:1904936 None DRD1, DRD2 2.19345
[BP] GO:0042321 None ADORA1, DRD2 2.19345
[BP] GO:0090325 None DRD2, DRD3 2.19345
[BP] GO:0010942 positive regulation of cell death BCL2, CNR1, CYP1B1, F3, HCAR2, MMP9, PIK3CB, PTGS2, SRC, XDH 2.19095
[BP] GO:0031099 regeneration AXL, BCL2, CSNK2A1, EGFR, FLT3 2.17497
[BP] GO:0007189 None ADRB1, DRD1, DRD2, DRD3 2.17483
[BP] GO:0046320 None CNR1, FABP3, PPARA 2.16633
[BP] GO:0033032 regulation of myeloid cell apoptotic process BCL2, HCAR2, PIK3CB 2.16633
[BP] GO:0050873 None ADRB1, FABP4, PTGS2 2.16633
[BP] GO:0042417 None DRD1, DRD2, DRD3 2.16633
[BP] GO:0008209 androgen metabolic process CYP19A1, CYP3A4, ESR1 2.16633
[BP] GO:0014059 None CNR1, DRD2, DRD3 2.16633
[BP] GO:0032147 activation of protein kinase activity ADORA1, DRD2, EGFR, PIK3CA, PIK3CB, PTPN1, SRC 2.16633
[BP] GO:0009314 response to radiation AURKB, BCL2, DRD1, DRD2, DRD3, EGFR, PTGS2, TYR 2.16628
[BP] GO:0050708 None ACHE, CACNA1C, CNR1, DRD2, DRD3, EGFR, HCAR2, SRC 2.1551
[BP] GO:0055065 metal ion homeostasis BCL2, CACNA1C, DRD1, DRD2, DRD3, EGFR, ESR1, F2, PIK3CB 2.14416
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, EGFR, FLT3, PTGS2 2.14416
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRB1, AURKB, BCL2, CA9, CDC25B, CNR1, CSNK2A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, HCAR2, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, XDH 2.13059
[BP] GO:0033280 response to vitamin D ALPL, PTGS2, TYR 2.12788
[BP] GO:0051128 regulation of cellular component organization AURKB, AXL, BCL2, CNR1, CSNK2A1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, F2, IGF1R, KDR, MET, MMP1, MMP9, PIK3CB, PTPN1, SRC 2.1221
[BP] GO:0048609 multicellular organismal reproductive process AKR1B1, AXL, CNR1, CYP1A1, DRD1, EGFR, ESR1, PTGS2, SRC 2.11837
[BP] GO:0031328 positive regulation of cellular biosynthetic process ADRB1, AURKB, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, MET, PPARA, PTGS2, SRC 2.11139
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, EGFR, ERBB2, ESR1, F2, F3, FABP4, FLT3, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.10856
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.10297
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CACNA1C, CNR1, CYP19A1, DRD2, DRD3, EGFR, HCAR2, SRC 2.10277
[BP] GO:0051924 regulation of calcium ion transport BCL2, CACNA1C, DRD1, DRD2, F2, PTGS2 2.09991
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, DRD1, EGFR, ERBB2, ESR1, FLT3, IGF1R, MMP2, PTGS2, SRC 2.0995
[BP] GO:0051302 None AURKB, CDC25B, DRD2, DRD3, ESRRB 2.09694
[BP] GO:0035265 organ growth BCL2, CYP19A1, ESR1 2.09363
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.09363
[BP] GO:0046427 positive regulation of JAK-STAT cascade AKR1B1, CYP1B1, F2, FLT3 2.08754
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ADRB1, AURKB, BCL2, CA9, CDC25B, CNR1, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, XDH 2.0847
[BP] GO:0034762 None BCL2, CA2, CACNA1C, DRD1, DRD2, DRD3, F2, MMP9 2.06898
[BP] GO:0042220 None CNR1, DRD2, DRD3 2.06453
[BP] GO:0071276 cellular response to cadmium ion CYP1A2, EGFR, MMP9 2.06453
[BP] GO:0045744 None DRD2, DRD3, MET 2.06453
[BP] GO:0010039 response to iron ion BCL2, CYP1A1, DRD2 2.06453
[BP] GO:0033029 regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.06453
[BP] GO:0021843 None DRD1, DRD2 2.06453
[BP] GO:0051902 negative regulation of mitochondrial depolarization BCL2, SRC 2.06453
[BP] GO:0046113 None AOX1, XDH 2.06453
[BP] GO:0021830 None DRD1, DRD2 2.06453
[BP] GO:0032229 None ADORA1, CNR2 2.06453
[BP] GO:0002933 lipid hydroxylation CYP1A1, CYP3A4 2.06453
[BP] GO:0021826 None DRD1, DRD2 2.06453
[BP] GO:1904894 positive regulation of STAT cascade AKR1B1, CYP1B1, F2, FLT3 2.06269
[BP] GO:1900542 None ADRB1, DRD1, DRD2, DRD3, ESRRB, PPARA 2.04188
[BP] GO:0007611 None CNR1, DRD1, DRD2, DRD3, EGFR, PTGS2 2.03602
[BP] GO:0022029 None DRD1, DRD2, EGFR 2.03602
[BP] GO:0043278 None CNR1, DRD2, DRD3 2.03602
[BP] GO:0014072 None CNR1, DRD2, DRD3 2.03602
[BP] GO:0098801 None ADORA1, DRD2, DRD3 2.03602
[BP] GO:0042596 None ADRB1, BCL2, DRD1 2.03602
[BP] GO:0001763 morphogenesis of a branching structure BCL2, DRD2, ESR1, MET, SRC 2.03074
[BP] GO:2000116 regulation of cysteine-type endopeptidase activity CSNK2A1, F3, MMP9, PTGS2, SRC, XDH 2.03074
[BP] GO:2000106 regulation of leukocyte apoptotic process AURKB, AXL, HCAR2, PIK3CB 2.01082
[BP] GO:0090218 positive regulation of lipid kinase activity F2, FLT3, SRC 2.00098
[BP] GO:0010907 None ESRRB, PPARA, SRC 2.00098
[BP] GO:2001024 negative regulation of response to drug CNR1, DRD2, MET 2.00098
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ADRB1, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, F2, F3, FLT3, HCAR2, HSD17B2, IGF1R, KDR, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, SRC, TYR 3.70193
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, ADRB1, AKR1B1, AKR1B10, ALOX5, AOX1, AURKB, BCL2, CA1, CA2, CA3, CA4, CA5A, CA5B, CA7, CACNA1C, CDC25B, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, F2, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, KDR, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TYR, XDH 3.70063
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRB1, ALOX5, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, F2, F3, FLT3, HCAR2, HSD17B2, IGF1R, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TYR 3.62795
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRB1, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CNR1, CNR2, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, F2, F3, FLT3, HCAR2, IGF1R, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTPN1, SRC 3.58685
[CC] GO:0044432 endoplasmic reticulum part BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, EGFR, F2, FLT3, HSD17B2, PTGS1, PTGS2, PTPN1 3.53643
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, EGFR, HSD17B2, PTGS1, PTGS2 3.34194
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ADRB1, AXL, CA2, CA4, CA9, CACNA1C, CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, ERBB2, F2, F3, FLT3, IGF1R, KDR, MET, PTGS2, SRC 2.59904
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, ERBB2 2.46443
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, CNR1, DRD1, DRD2, EGFR, ERBB2, MET, PTGS2, SRC 2.06453
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.06453
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRB1, AXL, CA4, CNR1, CNR2, DRD1, DRD2, DRD3, F3, FLT3, IGF1R, KDR, MET 2.03602
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 19.7393
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, PTPN1, TYR, XDH 18.481
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, SRC, TYR, XDH 15.0294
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 12.6234
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 11.2575
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, EGFR, ERBB2, F2, F3, FLT3, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TYR, XDH 10.687
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4 10.276
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, PTGS1, PTGS2, PTPN1, TYR, XDH 9.6408
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, PTGS1, PTGS2, SRC 8.94829
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, CYP3A4 8.85467
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, PTGS1, PTGS2, SRC 8.64746
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, NQO2, PPARA, PTPN1 8.34831
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 8.25278
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, PTGS1, PTGS2, TYR 8.20189
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, XDH 8.06508
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, SRC 7.95803
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 7.48905
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, TYR 7.48905
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F2, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, PTGS1, PTGS2, PTPN1, TYR, XDH 7.43081
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, HSD17B1, NQO2, PTGS1, PTGS2, SRC, XDH 7.15616
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRB1, AXL, CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HCAR2, IGF1R, KDR, MET, PPARA 6.99819
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, CYP3A4 6.99642
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2D6, CYP3A4 6.17144
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET 6.12756
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRB1, AXL, CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HCAR2, IGF1R, KDR, MET, PPARA 6.12686
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRB1, AXL, CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HCAR2, IGF1R, KDR, MET, PPARA 5.89604
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET 5.51333
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRB1, AXL, CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HCAR2, IGF1R, KDR, MET, PPARA 5.45891
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, SRC 4.33528
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD17B1 4.02466
[MF] GO:1901338 None ADRB1, DRD1, DRD2, DRD3 4.00089
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA 3.92535
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.92535
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRB1, AXL, CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FLT3, HCAR2, IGF1R, KDR, MET 3.68566
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRB1, AXL, CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FLT3, HCAR2, IGF1R, KDR, MET 3.68566
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.57208
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 3.53643
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIK3CA, PIM1, SRC 3.41543
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.40175
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, ERBB2, KDR 3.40175
[MF] GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity EGFR, ERBB2, MET, PIK3CA, PIK3CB 3.37053
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC 3.3615
[MF] GO:0052813 phosphatidylinositol bisphosphate kinase activity EGFR, ERBB2, MET, PIK3CA, PIK3CB 3.30295
[MF] GO:0008289 lipid binding AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, HSD17B1, PPARA 3.30077
[MF] GO:0035004 phosphatidylinositol 3-kinase activity EGFR, ERBB2, MET, PIK3CA, PIK3CB 3.18473
[MF] GO:0043560 insulin receptor substrate binding IGF1R, PIK3CA, PIK3CB 3.17865
[MF] GO:0004952 None DRD1, DRD2, DRD3 3.08264
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD17B1, HSD17B2, XDH 3.08231
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC 3.04467
[MF] GO:0035240 None DRD1, DRD2, DRD3 2.99437
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.99239
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.99239
[MF] GO:0008389 None CYP2A13, CYP2A6 2.99239
[MF] GO:0042802 identical protein binding ACHE, AOX1, BCL2, CSNK2A1, DRD2, EGFR, ERBB2, ESR1, ESR2, FLT3, IGF1R, KDR, MET, MMP9, NQO2, PTGS2, TYR, XDH 2.95855
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, NQO2 2.95855
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.85347
[MF] GO:0019902 phosphatase binding BCL2, EGFR, ERBB2, MET, PPARA, PTPN1 2.71617
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.61288
[MF] GO:0004949 None CNR1, CNR2 2.61288
[MF] GO:0097159 organic cyclic compound binding ADORA1, ADRB1, AOX1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD17B1, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, SRC, XDH 2.5497
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, EGFR, ESRRB, FLT3, IGF1R, KDR, MMP9, PIM1, PPARA, PTPN1, SRC 2.52823
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC 2.43957
[MF] GO:0019903 protein phosphatase binding BCL2, EGFR, ERBB2, MET, PTPN1 2.39912
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.37246
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.37246
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.37246
[MF] GO:0032403 protein complex binding ACHE, ADORA1, EGFR, ESRRB, FLT3, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC 2.19512
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.19345
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.19345
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, DRD3 2.16033
[MF] GO:0046983 protein dimerization activity ACHE, ADORA1, ADRB1, AOX1, AXL, BCL2, DRD2, EGFR, ERBB2, FLT3, NQO2, PTGS2, TYR, XDH 2.1555
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.06453
[MF] GO:0004064 arylesterase activity CA1, CA2 2.06453
[MF] GO:0043546 None AOX1, XDH 2.06453
[MF] GO:0019899 enzyme binding ADRB1, AURKB, BCL2, CDC25B, CYP1A1, CYP1A2, CYP2A6, CYP3A4, EGFR, ERBB2, ESR1, ESR2, ESRRB, F3, MET, PPARA, PTGS2, PTPN1, SRC 2.03602


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA3, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 21.0707
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 9.2311
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, ERBB2, KDR, PIK3CB, MMP9, MET, ESR1, EGFR, IGF1R 8.1983
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, ADORA1, ADRB1, PIK3CB, PTGS2, PTGS1 7.4036
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, EGFR, ESR2 7.2634
Pathways in cancer_Homo sapiens_hsa05200 PIK3CA, FLT3, MMP1, MMP2, ERBB2, BCL2, PIK3CB, PTGS2, MMP9, MET, EGFR, IGF1R 6.7051
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 7.3901
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, ERBB2, MMP9, EGFR 6.8874
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP2A6, CYP2A13, CYP2D6, CYP1A2, CYP1A1, CYP1B1, CYP3A4 6.8874
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, ERBB2, MET, EGFR, IGF1R 6.8874
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, PIK3CA, ADORA1, ADRB1, CACNA1C, PIK3CB, DRD1, DRD2, PPARA 6.3744
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, ERBB2, KDR, BCL2, PIK3CB, MET, EGFR, IGF1R 6.353
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, CNR1, KDR, PIK3CB, DRD2, MET, EGFR, IGF1R 6.2222
MicroRNAs in cancer_Homo sapiens_hsa05206 PIK3CA, ERBB2, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, EGFR, CDC25B 6.0501
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP3A4 6.6594
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, ERBB2, PIK3CB, MET, EGFR 5.8911
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CNR2, CNR1, ADORA3, ADORA1, ADRB1, DRD1, F2, DRD2, DRD3 5.3286
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, BCL2, PIM1, PIK3CB, F3 4.9248
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, ERBB2, BCL2, PIK3CB, EGFR, IGF1R 5.2269
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, PTGS2, TYR, CYP3A4, CYP19A1, PTGS1, CYP2A6, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 4.537
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, ERBB2, BCL2, PIK3CB, EGFR, IGF1R 4.8959
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 4.7592
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB, MET, EGFR, IGF1R 4.5033
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1, ESR2 4.4897
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1, CYP3A4 4.6407
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP2D6, CYP1A2, AOX1, CYP3A4 4.537
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, CACNA1C, PIK3CB, PTGS2, EGFR 3.9931
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, ADORA1, ADRB1, CACNA1C, PIK3CB 3.871
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, ERBB2, PIK3CB, EGFR 4.1166
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, PIK3CA, BCL2, CACNA1C, PIK3CB 3.6826
Gap junction_Homo sapiens_hsa04540 SRC, ADRB1, DRD1, DRD2, EGFR 4.1071
Serotonergic synapse_Homo sapiens_hsa04726 CYP2D6, ALOX5, CACNA1C, PTGS2, PTGS1 3.6799
Ras signaling pathway_Homo sapiens_hsa04014 PIK3CA, KDR, PIK3CB, MET, EGFR, IGF1R 3.25
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, BCL2, ADORA1, PIK3CB 3.5604
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 PIK3CA, KDR, BCL2, PIK3CB, MET, EGFR, IGF1R 3.1713
Hepatitis B_Homo sapiens_hsa05161 PIK3CA, SRC, BCL2, PIK3CB, MMP9 3.218
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, ADRB1, CACNA1C, PIK3CB 3.2041
Non-small cell lung cancer_Homo sapiens_hsa05223 PIK3CA, ERBB2, PIK3CB, EGFR 3.6826
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, ERBB2, PIK3CB, EGFR 3.7849
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, ADRB1, MET, EGFR, IGF1R 3.0156
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, AOX1, PIK3CB 3.0921
Glioma_Homo sapiens_hsa05214 PIK3CA, PIK3CB, EGFR, IGF1R 3.4743
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.6763
Pancreatic cancer_Homo sapiens_hsa05212 PIK3CA, ERBB2, PIK3CB, EGFR 3.4593
Calcium signaling pathway_Homo sapiens_hsa04020 ERBB2, ADRB1, CACNA1C, DRD1, EGFR 2.8739
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 4.1715
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 2.9014
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, CACNA1C, EGFR 3.0156
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 3.218
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, BCL2, PIK3CB, PTGS2 3.0921
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.7442
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, PIK3CB, PPARA 2.751
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.3945
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 PIK3CA, SRC, PIK3CB, F2, EGFR 2.6035
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.6133
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1 2.6602
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB 2.6602
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.6602
Dopaminergic synapse_Homo sapiens_hsa04728 CACNA1C, DRD1, DRD2, DRD3 2.5375
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB, EGFR, IGF1R 2.5021
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA, EGFR 2.5021
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 PIK3CA, ESRRB, PIK3CB, IGF1R 2.43
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.0818
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB 1.95
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, PIK3CB 1.9817
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB, IGF1R 2.0157
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB, EGFR 1.9566
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.607
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3198
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB 1.6498
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3327
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.6304
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3429
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 2.0229
Alzheimer's disease_Homo sapiens_hsa05010 CACNA1C 0.3429
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, BCL2, PIK3CB 1.782
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1, CACNA1C, PTGS2 1.9566
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB, IGF1R 1.7481
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, PIK3CB 1.634
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB, PPARA 1.5569
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, PIK3CB, EGFR 1.607
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3947
HTLV-I infection_Homo sapiens_hsa05166 PIK3CA, PIK3CB 0.569
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.4356
Axon guidance_Homo sapiens_hsa04360 MET 0.43
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4357
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, SRC, PIK3CB 1.2654
Vascular smooth muscle contraction_Homo sapiens_hsa04270 CACNA1C 0.4415
Glutamatergic synapse_Homo sapiens_hsa04724 CACNA1C 0.4568
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.7765
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.776
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB 0.7852
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.9219
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 1.3584
MAPK signaling pathway_Homo sapiens_hsa04010 CACNA1C, EGFR, CDC25B 1.0752
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.934
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4974
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4983
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 0.9523
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.9654
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5113
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5103
Circadian entrainment_Homo sapiens_hsa04713 CACNA1C 0.5113
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB, IGF1R 2.4482
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5255
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5267
Salivary secretion_Homo sapiens_hsa04970 ADRB1 0.5267
Taste transduction_Homo sapiens_hsa04742 CACNA1C 0.5409
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5267
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.5349
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.4223
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.5409
Peroxisome_Homo sapiens_hsa04146 XDH 0.5409
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 1.1245
Colorectal cancer_Homo sapiens_hsa05210 PIK3CA, BCL2, PIK3CB 2.4751
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB 1.1355
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.5409
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.1355
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.5521
Renin secretion_Homo sapiens_hsa04924 ADORA1, ADRB1, CACNA1C 2.4482
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.569
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 1.1583
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.1663
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.2034
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.391
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.569
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5777
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 1.2165
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.569
Dilated cardiomyopathy_Homo sapiens_hsa05414 ADRB1, CACNA1C 1.2212
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 1.2349
Long-term potentiation_Homo sapiens_hsa04720 CACNA1C 0.5971
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, PTGS2, PTGS1 2.4751
Shigellosis_Homo sapiens_hsa05131 SRC 0.5998
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, CACNA1C, PIK3CB 2.7284
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6276
Chronic myeloid leukemia_Homo sapiens_hsa05220 PIK3CA, PIK3CB 1.3673
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.3673
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.4076
Complement and coagulation cascades_Homo sapiens_hsa04610 F2, F3 1.3124
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH 2.759
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.3813
Bile secretion_Homo sapiens_hsa04976 CA2, CYP3A4 1.3813
Amphetamine addiction_Homo sapiens_hsa05031 CACNA1C, DRD1 1.4152
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.4962
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6885
Malaria_Homo sapiens_hsa05144 MET 0.7011
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.5054
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.7111
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.706
Cocaine addiction_Homo sapiens_hsa05030 DRD1, DRD2 1.634
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.6916
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PIK3CA, PIK3CB 1.7964
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.9197
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.9817
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8938
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.8775
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP3A4 1.9996
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.8589
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.9485
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.9197
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.1755
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.4018
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.1583
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.4553


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)