TCM Prescription: Qiang Gan Pills



Prescription Description
Prescription IDTCMF5087
Pinyin NameQiang Gan Wan
Chinese Name强肝丸
English NameQiang Gan Pills
Function Description胁痛
IndicationsHypochondrium pain disorder
Disease ICD-11 Category SA00 [Hypochondrium pain disorder (TM1), 胁痛 (TM1) ];
Human Tissues Associated with IndicationHeart, Lung
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH407 Salvia miltiorrhiza 丹参 TCMH407 ITSAH2408-14
TCMH2532 Curcuma aromatica 郁金 TCMH2532 ITSAF2298-14
TCMH981 Astragalus membranaceus 黄芪 TCMH981 ITSAK2981-14
TCMH426 Codonopsis pilosula 党参 TCMH426 ITSAL4530-14
TCMH2581 Alisma orientale 泽泻 TCMH2581 KC573871
TCMH967 Polygonatum sibiricum 黄精 TCMH967 ITSAH4762-14
TCMH451 Rehmannia glutinosa 地黄 TCMH451 ITSAH4578-14
TCMH1845 Dioscorea batatas 山药 TCMH1845
TCMH1848 Crataegus pinnatifida 山楂 TCMH1848 ITSAH1684-14
TCMH1307 Massa medicata fermentata 六神曲 TCMH1307
TCMH2494 Artemisia capillaris 茵陈蒿 TCMH2494 ITSAN1371-14
TCMH127 Isatis indigotica 板蓝根 TCMH127 KJ765825
TCMH1673 Gentiana macrophylla 秦艽 TCMH1673 ITSAO2245-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT167 AKR1C3 Aldo-keto-reductase family 1 member C3 Oxidoreductase P42330
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT188 DHFR Dihydrofolate reductase Oxidoreductase P00374
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT193 RELA Nuclear factor NF-kappa-B p65 subunit Transcription factor Q04206
TCMT194 MAP3K7 Mitogen-activated protein kinase kinase kinase 7 Kinase O43318
TCMT195 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 Kinase Q02750
TCMT196 MAP2K7 Dual specificity mitogen-activated protein kinase kinase 7 Kinase O14733
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT211 CES1 Acyl coenzyme A:cholesterol acyltransferase Transferase P23141
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT230 HSD17B3 Estradiol 17-beta-dehydrogenase 3 Oxidoreductase P37058
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT265 GSK3B Glycogen synthase kinase-3 beta Kinase P49841
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT566 NOS2 Nitric oxide synthase, inducible Oxidoreductase P35228
TCMT570 ANPEP Aminopeptidase N Unclassified P15144
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT633 SLC6A4 Serotonin transporter Transporter P31645
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1168 Trichomonas vaginalis
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1206 Influenza A virus (A/PR/8/34(H1N1))
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1241 Human rhinovirus 14
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1285 Human coxsackievirus B3
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1313 Human immunodeficiency virus 2
TCMT1314 Streptococcus viridans
TCMT1321 Staphylococcus hominis
TCMT1333 Human rhinovirus 1A
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1347 Human rhinovirus 16
TCMT1348 Human rhinovirus 2
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1405 Penicillium citrinum
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, AKR1C3, APP, CES1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 12.4863
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AKR1C3, ALPL, APEX1, APP, AR, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESRRA, FABP3, GSK3B, HSD11B2, HSD17B2, IDO1, IGF1R, MMP2, MMP9, PPARA, PTGES, PTGS2, RELA, RORC, SLC6A4, SRC, TYR 12.445
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, APP, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, KIT, MET, PPARA, PTGES, PTGS2 12.3328
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DHFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, IDO1, IGF1R, KCNH2, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGES, PTGS2, PTPN1, RELA, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 12.3141
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DHFR, FABP3, FUT7, GBA2, GLO1, HSD17B3, IDO1, PIM1, PPARA, PTGES, PTGS2, TYR, XDH 12.2845
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DHFR 11.8618
[BP] GO:0042221 response to chemical ADRA2A, AKR1B1, AKR1C3, ALPL, APEX1, APP, AR, AXL, BCL2, CA2, CA9, CDK6, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GSK3B, HSD11B2, HSD17B2, IDO1, IGF1R, KCNH2, KDR, KIT, MMP2, MMP9, PPARA, PTGES, PTGS2, RELA, RORC, SLC6A2, SLC6A4, SRC, TERT, TYR 11.8618
[BP] GO:0033993 response to lipid AKR1C3, ALPL, AR, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, IDO1, PTGES, PTGS2, RELA, RORC, SLC6A4, SRC, TYR 11.5345
[BP] GO:0010033 response to organic substance ADRA2A, AKR1B1, AKR1C3, ALPL, APEX1, APP, AR, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GSK3B, HSD11B2, HSD17B2, IDO1, IGF1R, KDR, KIT, MMP2, PPARA, PTGES, PTGS2, RELA, RORC, SLC6A4, SRC, TYR 11.1493
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.0102
[BP] GO:0014070 response to organic cyclic compound AKR1C3, ALPL, APEX1, APP, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESRRA, FLT3, HSD11B2, PTGES, PTGS2, RELA, RORC, SLC6A4, SRC, TYR 10.5607
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, AKR1C3, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 10.3942
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA2A, AKR1B1, AKR1C3, APEX1, APP, AR, AURKB, AXL, BCL2, CA12, CA2, CA7, CACNA1C, CDK6, CYP19A1, CYP1A1, CYP1B1, DHFR, ESR1, F10, F3, FABP3, FABP4, FLT3, GSK3B, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, KCNH2, KDR, KIT, MAOA, MET, PPARA, PTGS2, SLC6A2, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 10.2576
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DHFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GSK3B, HSD17B1, HSD17B2, HSD17B3, IDO1, IGF1R, KCNH2, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, PIM1, PPARA, PTGES, PTGS2, PTPN1, RELA, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 10.1623
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1C3, APP, AR, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, ESR1, ESRRA, F3, FABP3, FLT3, IDO1, IGF1R, KDR, KIT, MAP2K1, MMP12, MMP2, MMP9, PIM1, PTGES, PTGS2, RELA, SLC6A4, SRC, TERT, XDH 9.95413
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA2A, AKR1B1, AKR1C3, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, F3, FLT3, GSK3B, HCAR2, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PTGS2, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 9.90248
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA2A, AKR1B1, AKR1C3, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, F3, FLT3, GSK3B, HCAR2, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PTGS2, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 9.8684
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DHFR, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, IDO1, MAOA, PTGS2, TYR, XDH 9.73984
[BP] GO:0009719 response to endogenous stimulus ADRA2A, AKR1B1, AKR1C3, ALPL, APEX1, APP, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, GSK3B, HSD11B2, IGF1R, KIT, MMP2, PPARA, PTGS2, RELA, SLC6A4, SRC 9.73984
[BP] GO:0009725 response to hormone ADRA2A, AKR1B1, AKR1C3, ALPL, APEX1, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, KIT, PPARA, PTGS2, RELA, SLC6A4, SRC 9.73984
[BP] GO:0010035 response to inorganic substance AKR1B1, AKR1C3, APEX1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, KIT, MMP9, PTGES, PTGS2, RELA, SRC, TERT 9.625
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AKR1C3, APEX1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GLO1, GSK3B, HCAR2, IDO1, IGF1R, KDR, KIT, MAP2K1, MET, MMP9, PIM1, PTGS2, PTPN1, RELA, SRC, TERT, TOP2A, XDH 9.34771
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AKR1C3, APEX1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GLO1, GSK3B, HCAR2, IDO1, IGF1R, KDR, KIT, MAP2K1, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, RELA, SRC, TERT, TOP2A, XDH 9.2818
[BP] GO:0033559 unsaturated fatty acid metabolic process AKR1C3, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, PTGES, PTGS2 9.24692
[BP] GO:0006690 icosanoid metabolic process AKR1C3, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, PTGES, PTGS2 8.93321
[BP] GO:0019369 arachidonic acid metabolic process AKR1C3, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, PTGES, PTGS2 8.73027
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, AKR1C3, ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CACNA1C, CDC25B, CDK6, CES1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, GSK3B, HSD11B1, HSD17B2, HSD17B3, KDR, KIT, MAP2K1, MET, MMP2, MMP9, PIM1, PPARA, PTGS2, RELA, RORC, SLC6A4, SRC, TERT, TNKS2, TOP2A, TYR 8.43487
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1C3, ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA6, CA9, CDK6, CES1, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESRRA, F10, F3, FABP3, FABP4, FLT3, GSK3B, HSD11B2, HSD17B2, IDO1, IGF1R, KCNH2, KDR, KIT, MAP2K1, MAP3K7, MMP12, MMP2, MMP9, PPARA, PTGES, PTGS2, PTPN1, RELA, RORC, SLC6A2, SLC6A4, SRC, TERT, TOP2A, TYR 8.3431
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA2A, AKR1B1, AKR1C3, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FLT3, GSK3B, HCAR2, IDO1, IGF1R, KCNH2, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, RELA, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 8.25806
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, AKR1C3, ALPL, APEX1, APP, AR, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GSK3B, IGF1R, KCNH2, KDR, KIT, MMP2, MMP9, PTGS2, RELA, RORC, SLC6A4, SRC, TERT 8.14209
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AKR1C3, APEX1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GLO1, GSK3B, HCAR2, IDO1, IGF1R, KDR, MAP2K1, MMP9, PIM1, PTGS2, PTPN1, RELA, SRC, TERT, TOP2A, XDH 8.0117
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA2A, AKR1B1, AKR1C3, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, F10, F3, FLT3, GSK3B, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PTGS2, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 7.95941
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 7.53098
[BP] GO:0032787 None AKR1C3, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FABP3, GBA2, GLO1, IDO1, PPARA, PTGES, PTGS2 7.48559
[BP] GO:0006631 fatty acid metabolic process AKR1C3, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FABP3, PPARA, PTGES, PTGS2 7.3599
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA2A, AKR1B1, AKR1C3, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GSK3B, HCAR2, IDO1, IGF1R, KCNH2, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, RELA, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 7.35283
[BP] GO:0048513 animal organ development ACHE, AKR1C3, AR, AXL, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, HSD17B3, KDR, KIT, MAP2K1, PPARA, RELA, SRC, TYR 7.32697
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, AKR1C3, ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, FABP4, FLT3, GSK3B, IGF1R, KCNH2, KDR, KIT, MAP2K1, MAP3K7, MMP2, MMP9, PTGS2, PTPN1, RELA, RORC, SLC6A4, SRC, TERT, TOP2A 7.28175
[BP] GO:1901568 fatty acid derivative metabolic process AKR1C3, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, PTGES, PTGS2 7.18516
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, AKR1C3, ALPL, APEX1, APP, AR, AXL, BCL2, CDK6, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, GSK3B, IGF1R, KDR, KIT, MMP2, PTGS2, RELA, RORC, SLC6A4, SRC 7.12485
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DHFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, IDO1, IGF1R, KCNH2, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGES, PTGS2, PTPN1, RELA, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 7.12425
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA2A, AKR1B1, AKR1C3, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, ESRRA, F10, F3, FABP4, FLT3, GSK3B, IDO1, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP2, MMP9, PTGS2, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 6.95942
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, GLO1, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, RELA, SRC, TERT 6.91119
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, GLO1, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTGS2, PTPN1, RELA, SRC, TERT 6.82978
[BP] GO:0042446 hormone biosynthetic process AKR1B1, AKR1C3, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 6.82771
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, AKR1C3, ALOX5, CES1, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FABP3, FABP4, FUT7, GBA2, KIT, MET, PPARA, PTGES, PTGS2 6.82335
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19 6.79362
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DHFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, IDO1, IGF1R, KCNH2, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGES, PTGS2, PTPN1, RELA, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 6.76078
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA2A, AKR1B1, AKR1C3, APP, AR, AXL, BCL2, CYP1B1, F10, F3, FLT3, KDR, KIT, MAP2K1, MAP3K7, MET, PTGS2, PTPN1, RELA, SRC, XDH 6.75152
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, AKR1C3, AR, BCL2, CDC25B, CDK6, CSNK2A1, ESR1, F3, FLT3, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, PIM1, PTGS2, RELA, TERT 6.73763
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, MAP3K7, PIM1, PPARA, RELA, RORC, SRC 6.72695
[BP] GO:0001676 long-chain fatty acid metabolic process AKR1C3, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, PTGES, PTGS2 6.53491
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA2A, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, APP, AR, AXL, BCL2, CACNA1C, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, F10, F3, FABP4, HSD11B2, HSD17B2, IDO1, IGF1R, KCNH2, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, RELA, RORC, SLC6A2, SLC6A4, SRC, TNKS2, TYR 6.38193
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADRA2A, AKR1B1, AKR1C3, CACNA1C, CYP19A1, CYP1A1, CYP1B1, ESR1, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 6.33032
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2, HSD17B3 6.25925
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1C3, APEX1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GSK3B, IDO1, IGF1R, KCNH2, KDR, KIT, MAP2K1, MET, MMP12, MMP9, PIM1, PPARA, PTGES, PTGS2, PTPN1, RELA, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 6.25291
[BP] GO:0019752 carboxylic acid metabolic process AKR1C3, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DHFR, FABP3, GBA2, GLO1, IDO1, PIM1, PPARA, PTGES, PTGS2, TYR 6.22645
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, AKR1C3, ALPL, APP, AR, AXL, BCL2, CA2, CACNA1C, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESRRA, ESRRB, FLT3, GBA2, GSK3B, HSD11B1, HSD17B2, HSD17B3, KDR, KIT, MAP2K1, MMP9, PIM1, PPARA, PTGS2, RELA, RORC, SRC, TYR 6.1749
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA2A, AKR1B1, AKR1C3, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F10, F3, FLT3, GSK3B, HCAR2, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PTGS2, PTPN1, RELA, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 6.14345
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA2A, AKR1B1, AKR1C3, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F10, F3, FLT3, GSK3B, HCAR2, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PTGS2, PTPN1, RELA, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 6.01141
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ADRA2A, APEX1, APP, BCL2, CACNA1C, CDK6, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 5.98539
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ADRA2A, APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 5.79161
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, DHFR, FABP3, HSD11B2, KCNH2, KDR, PTGS2, RELA, SLC6A2, SLC6A4, SRC 5.76365
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, AKR1C3, APP, BCL2, CES1, CYP19A1, CYP1A1, CYP1B1, DHFR, GBA2, HSD17B3, MAOA, TYR 5.75328
[BP] GO:0006694 steroid biosynthetic process AKR1B1, AKR1C3, CES1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 5.75086
[BP] GO:0022414 reproductive process AKR1B1, AKR1C3, ALPL, APP, AR, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, ESR1, ESRRB, HSD11B2, HSD17B2, HSD17B3, IDO1, KIT, MAP2K1, MMP2, MMP9, PTGS2, SLC6A4, SRC, TOP2A 5.6791
[BP] GO:0071407 cellular response to organic cyclic compound AKR1C3, ALPL, APEX1, APP, AR, CYP1A1, CYP1B1, ESR1, FLT3, PTGS2, RORC, SLC6A4, SRC 5.67653
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ADRA2A, APEX1, APP, AR, AXL, BCL2, CA2, CA7, CACNA1C, CDK6, CSNK2A1, CYP19A1, CYP1B1, F10, F3, GSK3B, HCAR2, IGF1R, KCNH2, KDR, KIT, MAP2K1, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, SLC6A4, SRC, TERT 5.66456
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AKR1C3, APEX1, APP, AR, AXL, CDK6, CYP1B1, ESR1, GSK3B, IGF1R, MMP2, MMP9, PTGS2, RELA, RORC, SLC6A4, SRC 5.63026
[BP] GO:0043436 oxoacid metabolic process AKR1C3, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DHFR, FABP3, GBA2, GLO1, IDO1, PIM1, PPARA, PTGES, PTGS2, TYR 5.59661
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, GLO1, GSK3B, IDO1, IGF1R, KDR, MMP9, PIM1, PTGS2, PTPN1, RELA, SRC, TERT 5.57223
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ADRA2A, APEX1, APP, BCL2, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 5.48212
[BP] GO:0006082 organic acid metabolic process AKR1C3, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DHFR, FABP3, GBA2, GLO1, IDO1, PIM1, PPARA, PTGES, PTGS2, TYR 5.48122
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA2A, AKR1C3, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DHFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GSK3B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, RELA, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 5.42827
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1C3, APEX1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GSK3B, HCAR2, IDO1, IGF1R, KCNH2, KDR, KIT, MAP2K1, MET, MMP12, MMP9, PIM1, PPARA, PTGES, PTGS2, PTPN1, RELA, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 5.3973
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA2A, APP, AR, AXL, BCL2, CA2, CACNA1C, CDK6, CHRM2, CYP1B1, ESR1, ESRRA, ESRRB, F3, GSK3B, HCAR2, IDO1, KCNH2, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIM1, PTGS2, RELA, SLC6A4, SRC, TERT, TNKS2, XDH 5.36005
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ADRA2A, APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 5.3121
[BP] GO:0010038 response to metal ion AKR1C3, APP, BCL2, CA2, CYP1A1, CYP1A2, FABP4, KIT, MMP9, PTGES, PTGS2, TERT 5.21657
[BP] GO:0042180 None AKR1B1, AKR1B10, AKR1C3, CYP19A1, GLO1, HSD17B3, IDO1 5.1801
[BP] GO:0001101 response to acid chemical AKR1B1, AKR1C3, DHFR, FABP3, HSD17B2, KDR, MMP2, PTGES, PTGS2, RELA, SLC6A4, SRC 5.1801
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA2A, AKR1B1, AKR1C3, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F10, F3, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PTGS2, PTPN1, RELA, SRC, XDH 5.17928
[BP] GO:0080134 regulation of response to stress ADORA1, ADRA2A, APP, CDK6, CYP19A1, DHFR, ESR1, F3, FABP4, GSK3B, IDO1, IGF1R, MAP2K1, MAP3K7, MET, MMP12, MMP2, PPARA, PTGS2, PTPN1, RELA, SRC, TERT, XDH 5.13062
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AKR1C3, AOX1, AURKB, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, FABP3, FABP4, FUT7, GBA2, GSK3B, IDO1, MAOA, MMP1, MMP12, MMP2, MMP9, SRC, XDH 5.1129
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AKR1C3, APEX1, AXL, CYP1B1, MMP9, RELA, SRC 5.1129
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADRA2A, AURKB, BCL2, CA2, CA7, CACNA1C, CDK6, HCAR2, KDR, PTGS2, SRC, TNKS, TNKS2 5.10472
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, GSK3B, IGF1R, KCNH2, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, SRC, TNKS 5.01212
[BP] GO:0048608 reproductive structure development AKR1C3, AR, AXL, BCL2, CYP19A1, ESR1, HSD17B2, HSD17B3, KIT, MAP2K1, SRC 5.01212
[BP] GO:0006805 xenobiotic metabolic process CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, RORC 4.948
[BP] GO:0048545 response to steroid hormone AKR1C3, ALPL, AR, BCL2, CA2, FLT3, HSD11B2, PTGS2, RELA, SRC 4.86385
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, ESR1, GSK3B, KIT, PPARA, RORC, SLC6A4, SRC, TOP2A 4.81139
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 4.7878
[BP] GO:0071495 cellular response to endogenous stimulus ADRA2A, AKR1B1, AKR1C3, APEX1, APP, AR, ESR1, FLT3, GSK3B, IGF1R, KIT, MMP2, PTGS2, RELA, SLC6A4, SRC 4.7657
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA2A, AKR1C3, APP, AR, AURKB, BCL2, CDC25B, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GSK3B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, RELA, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 4.75902
[BP] GO:0003006 developmental process involved in reproduction AKR1C3, ALPL, AR, AXL, BCL2, CDC25B, CYP19A1, ESR1, ESRRB, HSD17B2, HSD17B3, KIT, MAP2K1, PTGS2, SRC 4.72165
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA2A, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GSK3B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, RELA, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 4.7085
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, ADRA2A, AKR1C3, CYP1A1, FABP3, FLT3, HCAR2, KIT, PPARA, PTGS2, RORC, SRC 4.68733
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AKR1C3, APEX1, AXL, BCL2, CYP1B1, MMP9, RELA, SRC 4.68699
[BP] GO:0030335 positive regulation of cell migration ADRA2A, APP, BCL2, F10, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 4.6511
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA2A, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GSK3B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, RELA, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 4.64156
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 4.55752
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRA2A, AKR1B1, AKR1C3, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DHFR, ESR1, ESR2, ESRRA, F10, F3, FABP4, FLT3, GSK3B, IDO1, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP2, MMP9, PPARA, PTGS2, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 4.52362
[BP] GO:2000147 positive regulation of cell motility ADRA2A, APP, BCL2, F10, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 4.48706
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, AKR1C3, CES1, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, PTGES, PTGS2 4.37346
[BP] GO:0051272 positive regulation of cellular component movement ADRA2A, APP, BCL2, F10, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 4.3547
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, KIT, PIM1, SRC 4.27714
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SLC6A4, SRC, TERT 4.25173
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CES1, CYP1A1, CYP1B1, KDR, RELA, SLC6A4, SRC 4.25103
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA2A, APP, AR, AXL, BCL2, CA2, CYP1B1, ESRRB, F3, HCAR2, IDO1, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIM1, PTGS2, RELA, SRC, TERT 4.22047
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.22024
[BP] GO:0040017 positive regulation of locomotion ADRA2A, APP, BCL2, F10, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 4.20489
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, DHFR, FABP3, FLT3, GSK3B, HSD11B2, IGF1R, MMP2, PPARA, PTGS2, RELA, SLC6A4, SRC, TYR 4.20186
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SLC6A4, SRC, TERT 4.15511
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, GSK3B, MET, MMP9, PPARA, SRC, TERT 4.14367
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 4.10436
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, DHFR, ESR1, F10, F3, FLT3, FUT7, GBA2, GLO1, GSK3B, IDO1, IGF1R, KCNH2, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 4.09343
[BP] GO:0006979 response to oxidative stress AKR1B1, AKR1C3, APEX1, APP, AXL, BCL2, CYP1B1, MMP9, PTGS2, RELA, SRC 4.0915
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DHFR, FLT3, GSK3B, IGF1R, KCNH2, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, PTGS2, PTPN1, SRC, TNKS, XDH 4.07459
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, GSK3B, HSD11B2, IGF1R, PPARA, PTGS2, RELA, SRC 4.02301
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, RELA, SRC 3.9945
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CDK6, CYP1B1, KCNH2, KDR, PTGS2, RELA, SRC 3.96738
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, AR, BCL2, CDK6, CYP1B1, FABP3, IDO1, MAP2K1, PTGES, PTGS2, SLC6A4, TERT, XDH 3.93689
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, APEX1, APP, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DHFR, GSK3B, HSD11B2, IDO1, KIT, MAP2K1, MAP3K7, MMP2, MMP9, PPARA, PTGES, PTGS2, PTPN1, RELA, SLC6A2, SLC6A4, SRC, TERT, TOP2A 3.91951
[BP] GO:0044093 positive regulation of molecular function ADORA1, ADRA2A, APP, AR, AURKB, BCL2, CDC25B, DHFR, ESR1, ESR2, F3, FLT3, GSK3B, KIT, MAP2K1, MAP3K7, MET, MMP9, PTPN1, RELA, SRC, TERT, TNKS, XDH 3.8809
[BP] GO:0061370 testosterone biosynthetic process AKR1C3, CYP19A1, HSD17B3 3.87595
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, DHFR, IDO1, MAOA 3.87191
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SLC6A4, SRC, TERT 3.86005
[BP] GO:0009755 hormone-mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.82486
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, DHFR, FABP3, FLT3, GSK3B, HSD11B2, IGF1R, MMP2, PPARA, PTGS2, RELA, SLC6A4, SRC, TYR 3.81946
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, GSK3B, IGF1R, KCNH2, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, SRC, TNKS 3.7878
[BP] GO:0016137 None AKR1B1, AKR1B10, AKR1C3, GBA2 3.77401
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DHFR, FLT3, GSK3B, IGF1R, KCNH2, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, PTGS2, PTPN1, SRC, TNKS, XDH 3.7353
[BP] GO:0048869 cellular developmental process ACHE, AKR1C3, ALPL, APP, AR, AXL, BCL2, CDC25B, CDK6, CES1, CYP1A1, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, GSK3B, KDR, KIT, MAP2K1, MET, MMP2, MMP9, PTGS2, RORC, SRC, TERT, TOP2A 3.69222
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA2A, AKR1B1, AKR1C3, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, ESR2, F10, F3, FLT3, GSK3B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PTGS2, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 3.67116
[BP] GO:0009892 negative regulation of metabolic process ADORA1, ADRA2A, AKR1C3, APEX1, APP, AR, AURKB, BCL2, CSNK2A1, DHFR, ESR1, ESR2, ESRRA, FABP4, GSK3B, HCAR2, IGF1R, KDR, MAP2K1, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, RELA, RORC, SRC, TERT, TNKS, TNKS2, XDH 3.63774
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, KIT, MAP2K1, MET, SRC 3.50487
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, F10, FLT3, GSK3B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, SRC, TNKS, TOP2A 3.47272
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA2A, APP, AR, BCL2, CDC25B, ESRRB, FABP3, FLT3, KDR, KIT, MAP2K1, MAP3K7, MMP9, PTGS2, PTPN1, SRC, XDH 3.46778
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA2A, APP, AR, BCL2, CDC25B, ESRRB, FABP3, FLT3, KDR, KIT, MAP2K1, MAP3K7, MMP9, PTGS2, PTPN1, SRC, XDH 3.46778
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA2A, APP, AR, BCL2, CDC25B, ESRRB, FLT3, KDR, KIT, MAP2K1, MAP3K7, MMP9, PTGS2, PTPN1, SRC, XDH 3.46778
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, KIT, MAP2K1, MET, SRC 3.46778
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CDC25B, CDK6, CES1, CES2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DHFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GSK3B, HCAR2, HSD17B1, HSD17B2, HSD17B3, IDO1, IGF1R, KCNH2, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGES, PTGS2, PTPN1, RELA, RORC, SLC6A2, SLC6A4, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 3.41596
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.40059
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.40059
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, HSD11B2, KIT, MMP2, PPARA, PTGS2, RELA, SLC6A4, SRC, TERT, TYR 3.39868
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AKR1C3, APEX1, AXL, CYP1B1, MMP9, RELA, SRC 3.39773
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA2A, APP, AR, FLT3, KDR, KIT, MAP2K1, MAP3K7, PTPN1, SRC, XDH 3.30584
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.30584
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, GSK3B, MET, MMP9, PPARA, SRC, TERT, TNKS 3.29994
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, AKR1C3, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 3.28097
[BP] GO:0009991 response to extracellular stimulus AKR1C3, ALPL, AXL, BCL2, CYP1A1, HSD11B2, PTGS2, RELA, SLC6A4, SRC, TYR 3.23434
[BP] GO:0044598 None AKR1B1, AKR1B10, AKR1C3 3.2318
[BP] GO:0044597 None AKR1B1, AKR1B10, AKR1C3 3.2318
[BP] GO:0030638 None AKR1B1, AKR1B10, AKR1C3 3.2318
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CYP1A1, CYP1A2, IDO1, PTGES, PTGS2, RELA, SRC 3.20411
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA2A, AR, BCL2, ESR1, ESR2, GSK3B, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, RELA, SLC6A4, SRC, TERT, XDH 3.19198
[BP] GO:0006693 None AKR1C3, CES2, PTGES, PTGS2 3.18767
[BP] GO:0006692 None AKR1C3, CES2, PTGES, PTGS2 3.18767
[BP] GO:0044283 None AKR1B1, AKR1C3, ALOX5, CES1, CYP19A1, CYP1A1, DHFR, HSD17B3, IDO1, PTGES, PTGS2 3.18767
[BP] GO:0071396 cellular response to lipid AKR1C3, AR, AXL, CDK6, ESR1, FLT3, RELA, RORC, SLC6A4, SRC 3.18727
[BP] GO:0046686 response to cadmium ion AKR1C3, CYP1A2, KIT, MMP9, TERT 3.18727
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA2A, AR, BCL2, ESR1, ESR2, GSK3B, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, RELA, SLC6A4, SRC, TERT, XDH 3.18727
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRA2A, APP, AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, GSK3B, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS 3.18727
[BP] GO:0051896 regulation of protein kinase B signaling AKR1C3, AXL, F10, F3, KIT, MET, SRC, XDH 3.18104
[BP] GO:2001234 negative regulation of apoptotic signaling pathway AR, BCL2, MMP9, PTGS2, PTPN1, RELA, SRC, TERT 3.18104
[BP] GO:0051897 positive regulation of protein kinase B signaling AKR1C3, AXL, F10, F3, KIT, MET, SRC 3.14296
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA2A, APP, AR, BCL2, CDC25B, FLT3, KDR, KIT, MAP2K1, MAP3K7, MMP9, PTGS2, PTPN1, SRC, XDH 3.14039
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1C3, APP, AR, AXL, BCL2, CA1, CA2, CACNA1C, CDK6, CHRM2, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GSK3B, HCAR2, IGF1R, KCNH2, KDR, KIT, MAP2K1, MAP3K7, MET, MMP2, MMP9, PIM1, PPARA, PTGES, PTPN1, RELA, RORC, SRC, TNKS, TNKS2 3.09909
[BP] GO:0031960 response to corticosteroid AKR1C3, ALPL, BCL2, FLT3, HSD11B2, PTGS2, SRC 3.09424
[BP] GO:0030647 None AKR1B1, AKR1B10, AKR1C3 3.09424
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TERT, TNKS, TNKS2 3.09424
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 3.08102
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, ADRA2A, APP, AXL, BCL2, CA2, CYP19A1, GSK3B, HCAR2, KCNH2, MMP12, PTGS2, SLC6A4, SRC, TERT 3.05559
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, RELA 3.03234
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CYP1A1, CYP1A2, IDO1, PTGES, PTGS2, RELA, SRC 3.0208
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 3.0208
[BP] GO:0008283 cell proliferation ACHE, AR, AURKB, BCL2, CYP1A1, ESR1, FLT3, KIT, MAP2K1, MET, PIM1, SRC, TYR 3.00016
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, AKR1C3, CES1, CYP19A1, DHFR, HSD17B3, TYR 2.99014
[BP] GO:0006721 terpenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, CYP2C19 2.99014
[BP] GO:0035265 organ growth AR, BCL2, CYP19A1, ESR1 2.98019
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA2A, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DHFR, ESR1, F3, FABP4, FLT3, GSK3B, IGF1R, KIT, MAP2K1, MAP3K7, MMP9, PTGS2, PTPN1, SRC, TERT, TNKS, XDH 2.97044
[BP] GO:0007568 aging APEX1, AURKB, BCL2, CYP1A1, MAP2K1, PTGS2, RELA, TERT 2.93719
[BP] GO:0006940 None ADORA1, ADRA2A, CHRM2, KIT, PTGS2 2.91926
[BP] GO:0006081 None AKR1B10, AKR1C3, CYP1B1, GLO1, RELA 2.91926
[BP] GO:0051090 regulation of DNA binding transcription factor activity ADORA3, APP, AR, CYP1B1, ESR1, ESR2, KIT, MAP3K7, PIM1, RELA 2.91926
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA2A, AR, BCL2, CDK6, CYP19A1, ESR1, ESR2, GSK3B, IGF1R, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, RELA, SRC, TERT, XDH 2.91201
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA2A, APP, AR, BCL2, CDC25B, CSNK2A1, ESR1, F3, FLT3, GSK3B, KDR, KIT, MAP2K1, MAP3K7, MMP9, PTGS2, PTPN1, RELA, SRC, XDH 2.90772
[BP] GO:0042592 homeostatic process ADORA1, ADRA2A, AKR1B1, APEX1, APP, AXL, BCL2, CA12, CA2, CA7, CACNA1C, ESR1, FABP3, FABP4, FLT3, KCNH2, MET, SRC, TERT 2.90539
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, GSK3B, IGF1R, MMP2, PTGS2, RELA, SLC6A4, SRC 2.85952
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 2.85148
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 2.85148
[BP] GO:0019371 None AKR1C3, PTGES, PTGS2 2.85148
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA2A, APP, AR, BCL2, CDC25B, ESRRB, FABP4, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PPARA, PTGS2, PTPN1, SRC, XDH 2.84837
[BP] GO:0031667 response to nutrient levels AKR1C3, ALPL, BCL2, CYP1A1, HSD11B2, PTGS2, RELA, SLC6A4, SRC, TYR 2.7814
[BP] GO:0031324 negative regulation of cellular metabolic process ADRA2A, AKR1C3, APEX1, APP, AR, AURKB, BCL2, CSNK2A1, DHFR, ESR1, ESR2, ESRRA, FABP4, GSK3B, IGF1R, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, RELA, RORC, SRC, TERT, TNKS, TNKS2, XDH 2.7814
[BP] GO:0009605 response to external stimulus ADORA1, AKR1C3, ALPL, AXL, BCL2, CDK6, CHRM2, CYP1A1, CYP1A2, HSD11B2, IDO1, KIT, MMP12, PTGES, PTGS2, RELA, SLC6A4, SRC, TYR 2.75018
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR, RELA 2.75018
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP2C19 2.75018
[BP] GO:0030154 cell differentiation AKR1C3, ALPL, AR, AXL, BCL2, CDK6, CES1, CYP1A1, ESR1, FABP4, FLT3, FUT7, GLO1, GSK3B, KDR, KIT, MAP2K1, MMP2, MMP9, PTGS2, RORC, TOP2A 2.75018
[BP] GO:0016488 None AKR1B10, AKR1C3 2.75018
[BP] GO:0016487 None AKR1B10, AKR1C3 2.75018
[BP] GO:0016107 None AKR1B10, AKR1C3 2.75018
[BP] GO:0009115 None AOX1, XDH 2.75018
[BP] GO:0006714 None AKR1B10, AKR1C3 2.75018
[BP] GO:0009891 positive regulation of biosynthetic process APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, KDR, MAP2K1, MET, MMP12, PPARA, PTGS2, RELA, RORC, SRC, TERT, TNKS, TNKS2, TOP2A 2.7458
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, KIT, PPARA, PTGS2, SRC 2.71
[BP] GO:0043065 positive regulation of apoptotic process AKR1C3, BCL2, CYP1B1, F3, GSK3B, HCAR2, IDO1, MMP9, PTGS2, SRC, TOP2A, XDH 2.69425
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRA2A, APP, AURKB, BCL2, CDC25B, DHFR, ESR1, F3, FLT3, GSK3B, KIT, MAP2K1, MAP3K7, PTPN1, SRC, TERT, TNKS, XDH 2.68955
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, CYP2C19 2.67835
[BP] GO:0051130 positive regulation of cellular component organization APP, AR, AURKB, AXL, BCL2, ESR1, GSK3B, IGF1R, KDR, KIT, MAP2K1, MET, MMP1, MMP9, SRC, TNKS, TNKS2 2.67835
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.6629
[BP] GO:0043068 positive regulation of programmed cell death AKR1C3, BCL2, CYP1B1, F3, GSK3B, HCAR2, IDO1, MMP9, PTGS2, SRC, TOP2A, XDH 2.66126
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA2A, APP, AR, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, PTPN1, SRC, XDH 2.65614
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, PTGS2, TERT 2.6535
[BP] GO:0048806 genitalia development AXL, CYP19A1, ESR1, HSD17B3 2.64173
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, ADRA2A, FLT3, IGF1R, KIT, MAP2K1, MAP3K7, PTPN1, SRC 2.63381
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, GLO1, KIT, MMP9, RORC 2.63113
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, APP, GSK3B, IGF1R, MMP2, PTGS2, RELA, SLC6A4, SRC 2.62535
[BP] GO:0032870 cellular response to hormone stimulus ADRA2A, AKR1C3, APEX1, AR, ESR1, FLT3, KIT, RELA, SRC 2.60869
[BP] GO:0018107 peptidyl-threonine phosphorylation BCL2, CSNK2A1, GSK3B, MAP2K1, TNKS 2.60816
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, ADRA2A, FLT3, KIT, MAP2K1, MAP3K7, PTPN1, SRC 2.60203
[BP] GO:0046683 response to organophosphorus APEX1, APP, PTGS2, RELA, SLC6A4, TYR 2.60114
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ADRA2A, APP, AXL, BCL2, CA2, CA7, CACNA1C, CYP19A1, GSK3B, HCAR2, KCNH2, MAP2K1, MMP12, MMP9, PPARA, PTGS2, PTPN1, SLC6A4, SRC, TERT 2.59711
[BP] GO:0007584 response to nutrient AKR1C3, ALPL, CYP1A1, PTGS2, RELA, SLC6A4, TYR 2.59572
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRA2A, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DHFR, ESR1, ESR2, F3, FABP4, FLT3, GSK3B, IGF1R, KIT, MAP2K1, MAP3K7, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, RELA, SRC, TERT, TNKS, XDH 2.58614
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.58303
[BP] GO:0009607 response to biotic stimulus ALPL, AXL, BCL2, CDK6, CHRM2, CYP1A1, CYP1A2, GSK3B, IDO1, MMP12, PTGES, PTGS2, RELA, SRC 2.58084
[BP] GO:0050793 regulation of developmental process APP, AR, AXL, BCL2, CA2, CDK6, CYP1B1, ESR1, ESRRA, ESRRB, F3, GSK3B, IDO1, KDR, KIT, MAP2K1, PIM1, PPARA, PTGS2, RELA, RORC, SLC6A4, SRC, TERT, TNKS2, XDH 2.53563
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA2A, APP, AR, BCL2, CDC25B, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PPARA, PTGS2, PTPN1, SRC, XDH 2.53563
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, PTGS2, RELA, TYR 2.51982
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.4974
[BP] GO:0001816 cytokine production APP, FABP4, IDO1, KIT, PTGS2 2.4974
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA2A, APP, AR, BCL2, CDC25B, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PPARA, PTGS2, PTPN1, SRC, XDH 2.49192
[BP] GO:1901989 None APEX1, APP, CDC25B, CYP1A1, TERT 2.47529
[BP] GO:2000026 regulation of multicellular organismal development APP, AR, AXL, BCL2, CA2, CDK6, CYP1B1, ESR1, ESRRA, F3, GSK3B, IDO1, KDR, KIT, MAP2K1, PIM1, PTGS2, RELA, SLC6A4, SRC, TERT, XDH 2.46184
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC 2.46054
[BP] GO:0080135 regulation of cellular response to stress APP, CDK6, DHFR, GSK3B, IGF1R, MAP2K1, MAP3K7, MET, PTGS2, PTPN1, TERT, XDH 2.46054
[BP] GO:0018210 peptidyl-threonine modification BCL2, CSNK2A1, GSK3B, MAP2K1, TNKS 2.45785
[BP] GO:0006352 DNA-templated transcription, initiation AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.45433
[BP] GO:0044259 multicellular organismal macromolecule metabolic process AKR1C3, MMP1, MMP12, MMP2, MMP9 2.43775
[BP] GO:0043271 negative regulation of ion transport ADORA1, ADRA2A, BCL2, KCNH2, MMP9, PTGS2 2.43585
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.42823
[BP] GO:0070920 None ESR1, MAP2K1, TERT 2.42823
[BP] GO:1901653 cellular response to peptide AKR1B1, APEX1, APP, GSK3B, IGF1R, RELA, SRC 2.42438
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, CACNA1C, KDR, SRC 2.42438
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, MAP2K1, MET, MMP12, PPARA, PTGS2, RELA, RORC, SRC, TERT, TNKS, TNKS2, TOP2A 2.41389
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CYP1A1, MAP2K1, PIM1, TERT, TNKS, TOP2A 2.41389
[BP] GO:0010942 positive regulation of cell death AKR1C3, BCL2, CYP1B1, F3, GSK3B, HCAR2, IDO1, MMP9, PTGS2, SRC, TOP2A, XDH 2.40268
[BP] GO:0042133 neurotransmitter metabolic process ACHE, CYP1B1, DHFR, MAOA, SLC6A4 2.40252
[BP] GO:0032845 None ADORA1, ADRA2A, BCL2, SRC, TNKS, TNKS2 2.39752
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA2A, APP, AR, BCL2, CDC25B, FABP4, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PTGS2, PTPN1, SRC, XDH 2.39221
[BP] GO:0042136 neurotransmitter biosynthetic process ACHE, CYP1B1, DHFR, SLC6A4 2.37162
[BP] GO:0014074 response to purine-containing compound APEX1, APP, PTGS2, RELA, SLC6A4, TYR 2.37162
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.37162
[BP] GO:0046110 None AOX1, XDH 2.37162
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.37162
[BP] GO:0032227 negative regulation of synaptic transmission, dopaminergic PTGS2, SLC6A4 2.37162
[BP] GO:0016095 None AKR1B10, AKR1C3 2.37162
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, IGF1R, KDR, MAP2K1, MET, MMP12, PPARA, RELA, RORC, SRC, TERT, TNKS, TNKS2, TOP2A 2.36508
[BP] GO:0051094 positive regulation of developmental process APP, AR, AXL, BCL2, CA2, CYP1B1, ESRRB, F3, IDO1, KDR, KIT, MAP2K1, PIM1, PTGS2, RELA, SRC, TERT 2.36108
[BP] GO:0033554 cellular response to stress AKR1B1, AKR1C3, APEX1, AXL, BCL2, CA2, CA9, CYP1B1, DHFR, GSK3B, MAP2K1, MAP3K7, MMP9, PTGS2, PTPN1, RELA, SRC, TERT, TOP2A 2.36108
[BP] GO:0071248 cellular response to metal ion AKR1C3, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.35822
[BP] GO:0051338 regulation of transferase activity ADORA1, ADRA2A, APP, AURKB, CDC25B, FABP4, FLT3, GSK3B, IGF1R, KIT, MAP2K1, MAP3K7, PTPN1, SRC, TNKS 2.35566
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, ESR1, F3, FABP4, IDO1, KDR, MAP2K1, MET, MMP12, PPARA, PTGS2, RELA 2.35353
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRA2A, APP, AR, BCL2, CDC25B, ESR1, F3, FLT3, GSK3B, KDR, KIT, MAP2K1, MAP3K7, MMP9, PTGS2, PTPN1, SRC, XDH 2.34725
[BP] GO:2001233 regulation of apoptotic signaling pathway AR, BCL2, GSK3B, MMP9, PTGS2, PTPN1, RELA, SRC, TERT 2.33793
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, ESR1, FABP4, IDO1, MAP3K7, MMP12, MMP2, PPARA, PTGS2, PTPN1, RELA, SRC 2.33506
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AKR1C3, AOX1, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, FABP3, FABP4, GBA2, GSK3B, IDO1, MAOA, SRC, XDH 2.33218
[BP] GO:1901360 None ACHE, AKR1B1, AKR1B10, AKR1C3, AOX1, APEX1, APP, AR, BCL2, CES1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DHFR, ESR1, ESR2, ESRRA, ESRRB, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, IDO1, MAOA, MAP3K7, PPARA, PTGS2, RELA, RORC, TERT, TOP2A, TYR, XDH 2.33081
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, KIT, PTGS2, SLC6A4 2.28655
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, KIT, PTGS2, SLC6A4 2.28655
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MMP9, PTGS2, PTPN1, SRC 2.28481
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA2A, AKR1C3, APEX1, APP, AR, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GSK3B, HCAR2, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIM1, PPARA, PTGS2, PTPN1, RELA, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 2.27907
[BP] GO:0009894 regulation of catabolic process ADORA1, ADRA2A, APEX1, BCL2, CSNK2A1, ESRRB, GSK3B, HCAR2, KDR, MAP3K7, MET, PPARA, PTPN1, RELA 2.27783
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AKR1C3, AOX1, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, GBA2, GSK3B, IDO1, MAOA, XDH 2.27361
[BP] GO:0010906 None ESRRB, GSK3B, PPARA, RORC, SRC 2.26945
[BP] GO:0003014 None ADORA1, AKR1B1, AKR1C3, BCL2, HSD11B2 2.26945
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, HCAR2, PTGS2, TNKS, TNKS2 2.25408
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.25408
[BP] GO:0051726 regulation of cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, MAP2K1, PIM1, PTGS2, SLC6A4, SRC, TERT, TNKS, TOP2A 2.25048
[BP] GO:0043207 response to external biotic stimulus ALPL, AXL, BCL2, CDK6, CHRM2, CYP1A1, CYP1A2, IDO1, MMP12, PTGES, PTGS2, RELA, SRC 2.23899
[BP] GO:0050994 None ADORA1, ADRA2A, HCAR2, PPARA 2.20862
[BP] GO:0050730 None ADORA1, ADRA2A, APP, FLT3, KIT, PTPN1, SRC 2.20025
[BP] GO:0006937 None ADORA1, ADRA2A, CACNA1C, CHRM2, KIT, PTGS2 2.18874
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, IGF1R, MAP2K1, MET, MMP12, PPARA, PTPN1, RELA, RORC, SRC, TERT, TNKS, TNKS2, TOP2A 2.18874
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.18402
[BP] GO:0009968 negative regulation of signal transduction ADRA2A, AR, BCL2, ESR1, ESR2, GSK3B, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, RELA, SRC, TERT, XDH 2.18402
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PTPN1, SRC 2.1838
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, XDH 2.17885
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, CDK6, GSK3B, KDR, SRC 2.14527
[BP] GO:2001237 negative regulation of extrinsic apoptotic signaling pathway AR, BCL2, RELA, SRC, TERT 2.14527
[BP] GO:0043269 regulation of ion transport ADORA1, ADRA2A, APP, BCL2, CA2, CA7, CACNA1C, KCNH2, MMP9, PTGS2, SLC6A4 2.14017
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.13884
[BP] GO:0070213 None TNKS, TNKS2 2.12642
[BP] GO:0006145 None AOX1, XDH 2.12642
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.12642
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, FLT3, KDR, KIT, MAP2K1, TYR 2.11944
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA2A, APP, AR, BCL2, CDC25B, FLT3, KDR, KIT, MAP2K1, MAP3K7, MMP9, PTGS2, PTPN1, SRC, XDH 2.10165
[BP] GO:0048732 gland development AR, BCL2, CSNK2A1, CYP19A1, MAP2K1, RELA, TYR 2.10165
[BP] GO:0044236 multicellular organism metabolic process AKR1C3, MMP1, MMP12, MMP2, MMP9 2.10165
[BP] GO:2000377 regulation of reactive oxygen species metabolic process AKR1C3, BCL2, CYP1B1, DHFR, PTGS2, XDH 2.09694
[BP] GO:0051091 positive regulation of DNA binding transcription factor activity APP, AR, ESR1, ESR2, KIT, MAP3K7, RELA 2.09517
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.09517
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.09517
[BP] GO:0050995 None ADORA1, ADRA2A, HCAR2 2.09517
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, ESR1, IGF1R, MET, MMP9, PTGS2, PTPN1, RELA, SRC, XDH 2.08379
[BP] GO:0008406 gonad development AKR1C3, BCL2, CYP19A1, ESR1, KIT 2.07142
[BP] GO:0071241 cellular response to inorganic substance AKR1C3, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.06319
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, ADRA2A, FLT3, KIT, PTPN1, SRC 2.05171
[BP] GO:0044242 None AKR1B10, AKR1C3, CYP1B1, FABP3, FABP4, GBA2 2.05171
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.04269
[BP] GO:1904018 positive regulation of vasculature development CYP1B1, F3, KDR, KIT, PTGS2, TERT 2.02678
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.00967
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, APEX1, APP, AR, AURKB, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA7, CACNA1C, CDC25B, CDK6, CES1, CES2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DHFR, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, IDO1, KCNH2, KDR, KIT, MAOA, MAP2K1, MAP3K7, MMP2, MMP9, PIM1, PTGES, PTGS2, PTPN1, RELA, SLC6A4, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 5.21657
[CC] GO:0044432 endoplasmic reticulum part APP, BCL2, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, F10, FLT3, GBA2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, PTGES, PTGS2, PTPN1 4.23628
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRA2A, ALOX5, ALPL, APP, AR, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, ESR1, F10, F3, FLT3, FUT7, GBA2, GLO1, GSK3B, HCAR2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, IGF1R, KCNH2, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP2, PIM1, PTGES, PTGS2, PTPN1, SLC6A2, SLC6A4, SRC, TERT, TNKS, TNKS2, TYR 3.32145
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, PTGES 3.2318
[CC] GO:0005783 None ADORA1, APEX1, APP, BCL2, CA4, CES1, CES2, CYP19A1, FLT3, GBA2, HSD17B3, KDR, MAP2K1, PTGS2, PTPN1, XDH 3.16521
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, GBA2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, PTGES, PTGS2 2.75018
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRA2A, ALPL, APP, AR, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM2, CSNK2A1, ESR1, F10, F3, FLT3, GBA2, GLO1, GSK3B, HCAR2, IGF1R, KCNH2, KDR, KIT, MAP2K1, MAP3K7, MET, MMP2, PIM1, PTPN1, SLC6A2, SLC6A4, SRC, TERT 2.52196
[CC] GO:0043227 membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DHFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GSK3B, HSD17B3, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, RELA, RORC, SHBG, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 2.43775
[CC] GO:0043231 intracellular membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, APEX1, APP, AR, AURKB, BCL2, CA4, CA5A, CA5B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DHFR, ESR1, ESR2, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, GSK3B, HSD17B3, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MMP12, MMP2, PIM1, PPARA, PTGS2, PTPN1, RELA, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 2.26376
[CC] GO:0031233 None CA4, F10, F3 2.19232
[CC] GO:0043226 organelle ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CA9, CACNA1C, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DHFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GSK3B, HSD17B3, IDO1, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, RELA, RORC, SHBG, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 2.01731
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, APP, AR, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, TNKS, TYR, XDH 17.1471
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 16.0347
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DHFR, F10, F3, FLT3, FUT7, GBA2, GLO1, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, IDO1, IGF1R, KCNH2, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTGES, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 15.5588
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DHFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, GSK3B, HSD17B1, IDO1, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGES, PTGS2, PTPN1, RELA, RORC, SLC6A2, SLC6A4, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 13.8865
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DHFR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, IDO1, MAOA, PTGS2, TYR, XDH 10.5495
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.2576
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.1329
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, F10, GLO1, IDO1, KIT, MAP3K7, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 9.90248
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, F10, GLO1, IDO1, KIT, MAP3K7, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 9.70326
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, TNKS 8.93456
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1 7.54849
[MF] GO:0005496 steroid binding AR, ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, RORC, SHBG 7.01396
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, IDO1, PTGS2, SRC 6.8117
[MF] GO:0004497 monooxygenase activity AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, TYR 6.70998
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DHFR, HSD11B2, HSD17B1, IDO1, PTGES, PTGS2, SRC, XDH 6.62705
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AKR1C3, AOX1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, XDH 6.60733
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, IDO1, PTGS2, SRC 6.55147
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.25925
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1C3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 6.1749
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, PTGS2, TYR 6.13036
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 6.13036
[MF] GO:0004879 nuclear receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 6.13036
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, XDH 6.01141
[MF] GO:0016229 steroid dehydrogenase activity AKR1C3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 6.01052
[MF] GO:0003707 steroid hormone receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.61241
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, DHFR, FLT3, GSK3B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, PPARA, SLC6A4, SRC, TOP2A 5.03584
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19 4.94245
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 4.9392
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, AKR1C3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 4.81724
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, GSK3B, IGF1R, KCNH2, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, SRC 4.27809
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.18609
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2C19 4.13838
[MF] GO:0008289 lipid binding AR, AXL, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA, RORC, SHBG 4.12768
[MF] GO:0042802 identical protein binding ACHE, ADRA2A, AOX1, APP, BCL2, CSNK2A1, ESR1, ESR2, FLT3, IGF1R, KCNH2, KDR, KIT, MAP3K7, MET, MMP9, PTGS2, RELA, SLC6A4, TERT, TOP2A, TYR, XDH 3.84199
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 3.63295
[MF] GO:0016903 None AKR1B1, AKR1B10, AKR1C3, AOX1, XDH 3.63113
[MF] GO:0047035 testosterone dehydrogenase (NAD+) activity AKR1C3, HSD17B2, HSD17B3 3.61304
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MAP2K1, MET, SRC 3.59071
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, ADRA2A, APEX1, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, RELA, SLC6A4, SRC 3.47072
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, FLT3, GSK3B, IGF1R, KCNH2, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, SRC 3.41464
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ADRA2A, APEX1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, RELA, SLC6A4, SRC 3.36613
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA2A, AR, AXL, CHRM2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, IGF1R, KCNH2, KDR, KIT, MET, PPARA, RORC 3.32367
[MF] GO:0019899 enzyme binding ADRA2A, APP, AR, AURKB, BCL2, CDC25B, CYP1A1, CYP1A2, CYP2A6, CYP2C19, ESR1, ESR2, ESRRB, F3, GSK3B, KCNH2, KIT, MET, PPARA, PTGS2, PTPN1, RELA, SLC6A4, SRC, TNKS2, TOP2A 3.29912
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA2A, AR, AXL, CHRM2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, IGF1R, KCNH2, KDR, KIT, MAP2K1, MAP3K7, MET, PPARA, RORC 3.04436
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, GSK3B, IGF1R, KCNH2, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, SRC 3.03367
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, XDH 2.97073
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA2A, AR, AXL, CDK6, CHRM2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, IGF1R, KCNH2, KDR, KIT, MET, PPARA, RORC 2.97044
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CSNK2A1, FLT3, GSK3B, IGF1R, KCNH2, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, SRC, TERT 2.84063
[MF] GO:0042803 protein homodimerization activity ACHE, ADRA2A, AOX1, BCL2, FLT3, KCNH2, KIT, PTGS2, RELA, SLC6A4, TERT, TOP2A, TYR, XDH 2.80593
[MF] GO:0008134 transcription factor binding APEX1, AR, BCL2, ESR1, ESRRB, FLT3, GSK3B, PIM1, PPARA, RELA, SRC, TERT 2.78966
[MF] GO:0045550 None AKR1B10, AKR1C3 2.75018
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.75018
[MF] GO:0003845 None HSD11B1, HSD11B2 2.75018
[MF] GO:0008389 None CYP2A13, CYP2A6 2.75018
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA2A, AR, AXL, CHRM2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, IGF1R, KCNH2, KDR, KIT, MET, PPARA, RORC 2.69425
[MF] GO:0042562 hormone binding ACHE, AR, HSD17B1, IGF1R, SHBG 2.45785
[MF] GO:0097159 organic cyclic compound binding ADORA1, ADRA2A, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DHFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GSK3B, HSD11B2, HSD17B1, IDO1, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, PIM1, PPARA, PTGS2, PTPN1, RELA, RORC, SHBG, SLC6A4, SRC, TERT, TOP2A, XDH 2.39625
[MF] GO:0046983 protein dimerization activity ACHE, ADORA1, ADRA2A, AOX1, AR, AXL, BCL2, FLT3, KCNH2, KIT, PTGS2, RELA, SLC6A4, TERT, TOP2A, TYR, XDH 2.37162
[MF] GO:0008392 None CYP2A13, CYP2A6, CYP2C19 2.37162
[MF] GO:0008391 None CYP2A13, CYP2A6, CYP2C19 2.37162
[MF] GO:0047718 None AKR1B10, AKR1C3 2.37162
[MF] GO:0005330 None SLC6A2, SLC6A4 2.37162
[MF] GO:0047045 None AKR1C3, HSD17B3 2.37162
[MF] GO:0047374 None CES1, CES2 2.37162
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.19232
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.12642
[MF] GO:0032795 None ADORA1, ADRA2A 2.12642
[MF] GO:0005497 None AR, SHBG 2.12642
[MF] GO:0003674 molecular_function ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CDC25B, CDK6, CES1, CES2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DHFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GSK3B, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, IDO1, IGF1R, KCNH2, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGES, PTGS2, PTPN1, RELA, RORC, SHBG, SLC6A2, SLC6A4, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 2.11479


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 17.1472
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, AKR1C3, CYP1B1, PTGS2, CYP19A1, IGF1R 10.1759
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, HSD17B3, AKR1C3, CYP1B1, CYP19A1 11.0845
Metabolic pathways_Homo sapiens_hsa01100 MAOA, HSD17B3, AKR1B1, PTGS2, CYP2C19, GBA2, CYP19A1, HSD11B1, FUT7, ALOX5, HSD17B1, HSD17B2, AOX1, XDH, AKR1C3, TYR, DHFR, CYP2A6, AKR1B10, CYP1A2, CYP1A1, ALPL, PTGES, IDO1, CES1 8.265
Pathways in cancer_Homo sapiens_hsa05200 GSK3B, MAP2K1, FLT3, MMP1, MMP2, PTGS2, MMP9, RELA, IGF1R, AR, CDK6, KIT, BCL2, MET 7.0006
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP2C19 6.9893
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, AOX1, CYP1B1, IDO1 6.2013
Serotonergic synapse_Homo sapiens_hsa04726 APP, MAP2K1, MAOA, ALOX5, CACNA1C, PTGS2, CYP2C19, SLC6A4 6.0364
Prolactin signaling pathway_Homo sapiens_hsa04917 GSK3B, MAP2K1, SRC, ESR1, ESR2, RELA 4.8102
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, GSK3B, MAP2K1, CDK6, KIT, KDR, BCL2, MET, RELA, IGF1R 4.4162
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 4.8102
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MAP3K7, MET, IGF1R 4.8102
Proteoglycans in cancer_Homo sapiens_hsa05205 MAP2K1, SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 4.3651
Prostate cancer_Homo sapiens_hsa05215 AR, GSK3B, MAP2K1, BCL2, RELA, IGF1R 4.4162
Bladder cancer_Homo sapiens_hsa05219 MAP2K1, SRC, MMP1, MMP2, MMP9 4.8102
Estrogen signaling pathway_Homo sapiens_hsa04915 MAP2K1, SRC, MMP2, MMP9, ESR1, ESR2 4.229
MicroRNAs in cancer_Homo sapiens_hsa05206 MAP2K1, CDK6, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B 4.1268
Acute myeloid leukemia_Homo sapiens_hsa05221 MAP2K1, FLT3, KIT, PIM1, RELA 4.229
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, MAP2K1, ADORA1, CACNA1C, PPARA, RELA 3.5659
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, AKR1C3, PTGS2, CYP2C19, PTGES 4.0934
Focal adhesion_Homo sapiens_hsa04510 GSK3B, MAP2K1, SRC, KDR, BCL2, MET, IGF1R 3.5438
Hepatitis B_Homo sapiens_hsa05161 MAP2K1, CDK6, SRC, BCL2, MMP9, RELA 3.4025
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, MAOA, CYP1A2, AOX1, CYP2C19 3.8857
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1, F3, RELA 3.1957
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, MAP2K1, BCL2, CACNA1C 3.0331
TNF signaling pathway_Homo sapiens_hsa04668 MAP2K1, PTGS2, MMP9, MAP3K7, RELA 3.0364
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2, MAP3K7, RELA 3.3501
Sphingolipid signaling pathway_Homo sapiens_hsa04071 MAP2K1, ADORA3, BCL2, ADORA1, RELA 2.9147
Rap1 signaling pathway_Homo sapiens_hsa04015 MAP2K1, SRC, KIT, KDR, MET, IGF1R 2.7181
VEGF signaling pathway_Homo sapiens_hsa04370 MAP2K1, SRC, KDR, PTGS2 2.994
Measles_Homo sapiens_hsa05162 GSK3B, CDK6, CSNK2A1, MAP3K7, RELA 2.7181
Ras signaling pathway_Homo sapiens_hsa04014 MAP2K1, KIT, KDR, MET, RELA, IGF1R 2.5732
Central carbon metabolism in cancer_Homo sapiens_hsa05230 MAP2K1, FLT3, KIT, MET 2.8771
Melanoma_Homo sapiens_hsa05218 MAP2K1, CDK6, MET, IGF1R 2.8058
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH, CES2, CES1 3.3972
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 MAP2K1, ADORA3, ADORA1, CACNA1C, ADRA2A 2.3791
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1 2.9147
GnRH signaling pathway_Homo sapiens_hsa04912 MAP2K1, SRC, MMP2, CACNA1C 2.4647
Melanogenesis_Homo sapiens_hsa04916 GSK3B, MAP2K1, KIT, TYR 2.3322
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.8407
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2, PTGS2, RELA 2.5464
HIF-1 signaling pathway_Homo sapiens_hsa04066 MAP2K1, BCL2, RELA, IGF1R 2.2945
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, RELA, IGF1R 2.2738
T cell receptor signaling pathway_Homo sapiens_hsa04660 GSK3B, MAP2K1, MAP3K7, RELA 2.2887
Insulin resistance_Homo sapiens_hsa04931 PTPN1, GSK3B, PPARA, RELA 2.2323
Epstein-Barr virus infection_Homo sapiens_hsa05169 GSK3B, CSNK2A1, BCL2, MAP3K7, RELA 2.1157
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 GSK3B, MAP2K1, SRC, ESR1 2.1328
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2, MAP3K7, RELA 2.1328
Neurotrophin signaling pathway_Homo sapiens_hsa04722 GSK3B, MAP2K1, BCL2, RELA 2.1231
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 GSK3B, MAP2K1, ESRRB, IGF1R 1.9073
MAPK signaling pathway_Homo sapiens_hsa04010 MAP2K1, CACNA1C, MAP3K7, RELA, CDC25B 1.7675
Endocytosis_Homo sapiens_hsa04144 SRC, KIT, KDR, MET, IGF1R 1.7462
Oxytocin signaling pathway_Homo sapiens_hsa04921 MAP2K1, SRC, CACNA1C, PTGS2 1.7794
Chemokine signaling pathway_Homo sapiens_hsa04062 GSK3B, MAP2K1, SRC, RELA 1.5784
B cell receptor signaling pathway_Homo sapiens_hsa04662 GSK3B, MAP2K1, RELA 1.8781
Glioma_Homo sapiens_hsa05214 MAP2K1, CDK6, IGF1R 1.9755
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 MAP2K1, CDC25B, IGF1R 1.5844
Chronic myeloid leukemia_Homo sapiens_hsa05220 MAP2K1, CDK6, RELA 1.8781
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1, PTGS2 2.1274
Pancreatic cancer_Homo sapiens_hsa05212 MAP2K1, CDK6, RELA 1.9642
ErbB signaling pathway_Homo sapiens_hsa04012 GSK3B, MAP2K1, SRC 1.7003
Oocyte meiosis_Homo sapiens_hsa04114 AR, MAP2K1, IGF1R 1.3445
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 MAP2K1, MAP3K7, RELA 1.5105
Dopaminergic synapse_Homo sapiens_hsa04728 GSK3B, MAOA, CACNA1C 1.3068
Apoptosis_Homo sapiens_hsa04210 MAP2K1, BCL2, RELA 1.2427
Colorectal cancer_Homo sapiens_hsa05210 GSK3B, MAP2K1, BCL2 2.0257
Osteoclast differentiation_Homo sapiens_hsa04380 MAP2K1, MAP3K7, RELA 1.2871
Cell cycle_Homo sapiens_hsa04110 GSK3B, CDK6, CDC25B 1.3411
Leishmaniasis_Homo sapiens_hsa05140 PTGS2, MAP3K7, RELA 1.8781
Hepatitis C_Homo sapiens_hsa05160 GSK3B, PPARA, RELA 1.2841
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, RELA 1.9355
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, GSK3B, MAP2K1 1.2453
Wnt signaling pathway_Homo sapiens_hsa04310 GSK3B, CSNK2A1, MAP3K7 1.2363
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET 1.1854
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 GSK3B, PPARA, RELA 1.1942
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.1658
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, ADORA3, ADORA1, ADRA2A 1.1599
Purine metabolism_Homo sapiens_hsa00230 XDH 0.26
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.2694
Hippo signaling pathway_Homo sapiens_hsa04390 GSK3B 0.2965
Influenza A_Homo sapiens_hsa05164 GSK3B, MAP2K1, RELA 1.093
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2, RELA 1.0791
Alzheimer's disease_Homo sapiens_hsa05010 GSK3B, APP, CACNA1C 1.1327
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 MAP2K1 0.3328
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC, RELA 0.9594
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1, MAP3K7, RELA 1.0506
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, MAP2K1, SRC 0.9234
HTLV-I infection_Homo sapiens_hsa05166 GSK3B, TERT, RELA 0.7749
Platelet activation_Homo sapiens_hsa04611 SRC 0.363
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CACNA1C 0.6045
Alcoholism_Homo sapiens_hsa05034 MAP2K1, MAOA 0.6045
Glutamatergic synapse_Homo sapiens_hsa04724 CACNA1C 0.3829
AMPK signaling pathway_Homo sapiens_hsa04152 MAP3K7, IGF1R 0.7807
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.7342
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2, CACNA1C 0.7033
FoxO signaling pathway_Homo sapiens_hsa04068 MAP2K1, IGF1R 0.7515
Phospholipase D signaling pathway_Homo sapiens_hsa04072 MAP2K1, KIT 0.716
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.8055
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 RELA 0.4115
Axon guidance_Homo sapiens_hsa04360 GSK3B, MET 0.7742
Vascular smooth muscle contraction_Homo sapiens_hsa04270 MAP2K1, CACNA1C 0.797
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4191
Choline metabolism in cancer_Homo sapiens_hsa05231 MAP2K1 0.4191
Amoebiasis_Homo sapiens_hsa05146 RELA 0.4191
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4278
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.422
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 MAP2K1 0.4303
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4267
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, AOX1, TYR 2.5969
Circadian entrainment_Homo sapiens_hsa04713 CACNA1C 0.4278
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4353
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4366
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CACNA1C, PTGS2 0.909
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 RELA, IGF1R 0.9516
Dilated cardiomyopathy_Homo sapiens_hsa05414 CACNA1C 0.4366
Taste transduction_Homo sapiens_hsa04742 CACNA1C 0.4525
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4366
Salmonella infection_Homo sapiens_hsa05132 RELA 0.445
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.4465
Peroxisome_Homo sapiens_hsa04146 XDH 0.4525
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 0.994
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.4532
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 0.994
Gap junction_Homo sapiens_hsa04540 MAP2K1, SRC 0.994
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.4525
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.4641
Pertussis_Homo sapiens_hsa05133 RELA 0.4757
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4778
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.0665
Bile secretion_Homo sapiens_hsa04976 CA2 0.4876
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.4778
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 MAP2K1 0.498
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.4953
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.0607
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA, RELA 1.1341
Long-term potentiation_Homo sapiens_hsa04720 MAP2K1, CACNA1C 1.1629
Long-term depression_Homo sapiens_hsa04730 MAP2K1, IGF1R 1.2011
Renin secretion_Homo sapiens_hsa04924 ADORA1, CACNA1C 1.1658
Renal cell carcinoma_Homo sapiens_hsa05211 MAP2K1, MET 1.1629
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5177
Amphetamine addiction_Homo sapiens_hsa05031 MAOA, CACNA1C 1.1599
RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 MAP3K7, RELA 1.1341
Endometrial cancer_Homo sapiens_hsa05213 GSK3B, MAP2K1 1.2751
Non-small cell lung cancer_Homo sapiens_hsa05223 MAP2K1, CDK6 1.2363
Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 RELA 0.5177
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC, RELA 1.1658
Shigellosis_Homo sapiens_hsa05131 SRC, RELA 1.1658
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.2096
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 MAP3K7, RELA 1.2323
Cocaine addiction_Homo sapiens_hsa05030 MAOA, RELA 1.3068
Legionellosis_Homo sapiens_hsa05134 RELA 0.5694
Basal cell carcinoma_Homo sapiens_hsa05217 GSK3B 0.5694
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.5928
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.5976
Malaria_Homo sapiens_hsa05144 MET 0.5995
Hedgehog signaling pathway_Homo sapiens_hsa04340 GSK3B 0.5976
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6045
Type II diabetes mellitus_Homo sapiens_hsa04930 CACNA1C 0.6045
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6045
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 4.8102
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6045
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2 0.6615
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.6607
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.6578
Prion diseases_Homo sapiens_hsa05020 MAP2K1 0.7016
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.6578
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.7016
Thyroid cancer_Homo sapiens_hsa05216 MAP2K1 0.7513
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.6126
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.5324
Dorso-ventral axis formation_Homo sapiens_hsa04320 MAP2K1 0.7701
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP2C19 1.683
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7342
Base excision repair_Homo sapiens_hsa03410 APEX1 0.7156
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7513
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7749
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8471
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7409
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7701
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.797
One carbon pool by folate_Homo sapiens_hsa00670 DHFR 0.8614
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA 0.9176
Folate biosynthesis_Homo sapiens_hsa00790 DHFR, ALPL 2.1687
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.9014
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2357


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)