TCM Prescription: Zhuang Gu Guan Jie Pills



Prescription Description
Prescription IDTCMF465
Pinyin NameZhuang Gu Guan Jie Wan 
Chinese Name壮骨关节丸
English NameZhuang Gu Guan Jie Pills
Function Description骨性关节炎, 腰肌劳损, 症见关节肿胀, 疼痛, 麻木, 活动受限
IndicationsNumbness disorder, Arthritis, Rheumatoid arthritis
Disease ICD-11 Category SC62 [Numbness disorder (TM1), 麻木 (TM1) ];
FA2Z [Inflammatory arthropathies, unspecified, 炎性关节病,未特指的 ];
FA20 [Rheumatoid arthritis, 类风湿性关节炎 ];
Human Tissues Associated with IndicationBlood, SkeletaMuscle
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH693 Cudrania cochinchinensis 狗脊 TCMH693
TCMH517 Angelica pubescens 独活 TCMH517 ITSAF170-14
TCMH2334 Dipsacus japonicus 续断 TCMH2334 ITSAC1509-14
TCMH1791 Loranthus parasiticus 桑寄生 TCMH1791
TCMH1966 Rehmannia glutinosa 熟地黄 TCMH1966 ITSAH4578-14
TCMH1753 Boswellia carterii 乳香 TCMH1753
TCMH2507 Epimedium brevicornum 淫羊藿 TCMH2507 AY362429
TCMH700 Drynaria fortunei 骨碎补 TCMH700 GBVM3977-11
TCMH193 Psoralea corylifolia 补骨脂 TCMH193
TCMH1036 Spatholobus suberectus 鸡血藤 TCMH1036 ITSAK2607-14
TCMH1533 Saussurea lappa 木香 TCMH1533
TCMH1508 Commiphora myrrha 没药 TCMH1508 MH522406
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT377 INSR Insulin receptor Kinase P06213
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT619 HSP90AA1 Heat shock protein HSP 90-alpha Unclassified P07900
TCMT624 HSP90AB1 Heat shock protein HSP 90-beta Unclassified P08238
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT67 PPARG Peroxisome proliferator-activated receptor gamma Nuclear receptor P37231
TCMT689 TGM2 Protein-glutamine gamma-glutamyltransferase Transferase P21980
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT783 NR3C2 Mineralocorticoid receptor Nuclear receptor P08235
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT899 ALDH2 Aldehyde dehydrogenase Oxidoreductase P05091
TCMT904 PGR Progesterone receptor Nuclear receptor P06401
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718
TCMT974 GPER1 G-protein coupled estrogen receptor 1 GPCR Q99527
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1182 Streptococcus sanguinis
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1246 Escherichia coli
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, NR3C1, NR3C2, PGR, PPARA, PPARG, SRC 10.7164
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APP, AR, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, GPER1, IGF1R, INSR, MMP2, NR3C1, PPARA, PPARG, SMAD3, SRC, TEK 10.1536
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APP, AR, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FABP4, GPER1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP2, NR3C1, PPARA, PPARG, SMAD3, SRC, TEK 10.1336
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AR, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, GPER1, HSP90AB1, IGF1R, INSR, MMP2, MMP9, NR3C1, PPARA, PPARG, SRC, TEK 9.89439
[BP] GO:0009755 hormone-mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, NR3C1, NR3C2, PGR, PPARA, PPARG, SRC 9.87223
[BP] GO:0009725 response to hormone AKR1B1, ALPL, AR, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, GPER1, INSR, NR3C1, PPARA, PPARG, SRC, TEK 9.20366
[BP] GO:0042221 response to chemical AKR1B1, ALPL, APP, AR, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FABP4, GPER1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, PPARA, PPARG, SMAD3, SRC, TEK 8.75974
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, AR, CSNK2A1, CYP1B1, EGFR, ESR1, ESRRA, FABP3, GPER1, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PGR, PPARG, SMAD3, SRC, TEK, XDH 8.68703
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD17B1, MET, PPARA, PPARG 8.63748
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, AR, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, GPER1, HSP90AB1, NR3C1, PPARG, SRC, TEK 8.60645
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, NR3C1, PGR, PPARA, PPARG, SRC 8.37501
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALPL, AOX1, APP, AR, CA1, CA12, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FUT7, HSD11B1, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PPARA, PPARG, SMAD3, SRC, TEK, XDH 7.38948
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, PPARG 7.37628
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.29795
[BP] GO:0048513 animal organ development ACHE, AR, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, HSD11B1, HSP90AB1, INSR, KDR, PPARA, PPARG, SMAD3, SRC, TEK 7.03729
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APP, AR, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, GPER1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, PPARG, SMAD3, SRC 7.03729
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.90399
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, HSD11B1, HSD17B1 6.90399
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALDH2, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FUT7, HSPA1A, PPARA, PPARG, XDH 6.73803
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APP, AR, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, GPER1, GPR35, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PGR, PPARA, PPARG, SMAD3, SRC, TEK, XDH 6.73283
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALDH2, ALPL, AOX1, APP, AR, CA1, CA12, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FUT7, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, NR3C1, NR3C2, NUAK1, PGR, PPARA, PPARG, SMAD3, SRC, TEK, XDH 6.69143
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, APP, AR, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, FABP3, FABP4, GPER1, GPR35, HSD11B1, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, INSR, KDR, MET, PPARA, PPARG, SMAD3, SRC, TEK, XDH 6.53776
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, AR, CYP1A1, CYP1B1, EGFR, ESR1, GPER1, HSP90AB1, NR3C1, PPARG, SRC 6.53776
[BP] GO:0006352 DNA-templated transcription, initiation AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, PPARG 6.51823
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CYP19A1, DUSP3, EGFR, ESR1, FABP4, GPER1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, MET, MMP2, NUAK1, PPARA, PPARG, SMAD3, SRC, TEK, XDH 6.45657
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, CYP19A1, CYP1B1, EGFR, GPER1, IGF1R, INSR, KDR, MET, MMP9, PPARG, SMAD3, SRC, TEK 6.43298
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, APP, AR, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, GPER1, GPR35, HSP90AB1, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, XDH 6.36592
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, APP, AR, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, GPER1, GPR35, HSP90AB1, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, XDH 6.34236
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 6.26603
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APP, AR, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, GPER1, HSP90AB1, IGF1R, INSR, KDR, MMP2, NR3C1, PPARG, SMAD3, SRC 6.18757
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, CYP19A1, CYP1B1, EGFR, GPER1, IGF1R, INSR, KDR, MET, MMP9, PPARG, SMAD3, SRC, TEK 6.10752
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APP, AR, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPER1, GPR35, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PGR, PPARA, PPARG, SMAD3, SRC, TEK, XDH 5.98419
[BP] GO:0033993 response to lipid ALPL, AR, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, GPER1, NR3C1, PPARG, SRC 5.9744
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway AR, ESR1, ESR2, GPER1, NR3C1, PGR, SRC 5.82211
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.75749
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, CYP19A1, CYP1B1, EGFR, GPER1, IGF1R, INSR, KDR, MET, MMP9, PPARG, SMAD3, SRC, TEK 5.67911
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, CYP19A1, CYP1B1, EGFR, GPER1, IGF1R, INSR, KDR, MET, MMP9, PPARG, SMAD3, SRC, TEK 5.66681
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APP, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, GPER1, GPR35, HSP90AA1, HSP90AB1, INSR, MET, PPARG, SMAD3, SRC 5.50481
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, APP, AR, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, GPER1, GPR35, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PPARG, SMAD3, SRC, TEK, XDH 5.25351
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, APP, AR, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, GPER1, GPR35, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PPARG, SMAD3, SRC, TEK, XDH 5.15354
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, APP, AR, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, HSD11B1, HSP90AB1, INSR, KDR, MMP9, PGR, PPARA, PPARG, SMAD3, SRC, TEK 5.08727
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, APP, AR, CSNK2A1, CYP1B1, EGFR, ESRRA, FABP4, GPER1, GPR35, HSP90AA1, HSP90AB1, HSPA1A, INSR, KDR, MET, MMP2, MMP9, SMAD3, SRC, TEK, XDH 5.08102
[BP] GO:0009891 positive regulation of biosynthetic process APP, AR, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, GPER1, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, NR3C1, PGR, PPARA, PPARG, SMAD3, SRC 5.0722
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AR, CSNK2A1, CYP1B1, EGFR, ESR1, GPER1, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MMP9, PPARA, PPARG, SMAD3, SRC, TEK, XDH 5.04682
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AR, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, GPER1, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, SRC, TEK, XDH 5.04335
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, ALDH2, AOX1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, HSP90AA1, HSPA1A, MMP1, MMP2, MMP9, SRC, XDH 4.99373
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AR, EGFR, ESR1, ESR2, ESRRA, ESRRB, GPER1, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, NR3C1, PGR, PPARA, PPARG, SMAD3, SRC 4.97513
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AR, CYP1B1, EGFR, ESR1, GPER1, IGF1R, INSR, MMP2, MMP9, NR3C1, PPARG, SRC 4.9707
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APP, AR, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, GPER1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, NUAK1, PPARG, SMAD3, SRC 4.94204
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APP, AR, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, GPER1, GPR35, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, PPARA, PPARG, SMAD3, SRC, TEK 4.94131
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, APP, AR, CSNK2A1, CYP1B1, EGFR, GPER1, GPR35, HSP90AB1, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, XDH 4.88825
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AR, CSNK2A1, CYP1B1, EGFR, ESR1, GPER1, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MMP9, PPARG, SMAD3, SRC, TEK, XDH 4.86662
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, GPER1, PPARA, PPARG, SMAD3, TEK 4.83592
[BP] GO:1901654 None AKR1B1, AR, CA9, CSNK2A1, EGFR, NR3C1, PPARG, SRC 4.79837
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, APP, AR, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, GPER1, GPR35, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP2, MMP9, NUAK1, PPARA, PPARG, SMAD3, SRC, TEK, XDH 4.79837
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, ESR1, FABP4, GPER1, HSP90AB1, HSPA1A, MMP2, PPARA, PPARG, SMAD3, SRC, TEK 4.77873
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AR, EGFR, ESR1, ESR2, ESRRA, ESRRB, GPER1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, MET, NR3C1, PGR, PPARA, PPARG, SMAD3, SRC 4.77595
[BP] GO:0030335 positive regulation of cell migration APP, EGFR, GPER1, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.74869
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, APP, AR, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, GPER1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, PGR, PPARA, PPARG, SMAD3, SRC, TEK, XDH 4.73544
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, APP, AR, DUSP3, EGFR, ESRRB, FABP3, FABP4, GPER1, HSP90AB1, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, SMAD3, SRC, TEK, XDH 4.73544
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALPL, AOX1, APP, AR, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FUT7, HSD11B1, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PPARA, PPARG, SMAD3, SRC, TEK, XDH 4.72036
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD17B1 4.71733
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, GPER1, IGF1R, INSR, PPARA, PPARG, SRC, TEK 4.71506
[BP] GO:0018108 peptidyl-tyrosine phosphorylation EGFR, HSP90AA1, IGF1R, INSR, KDR, MET, SRC, TEK 4.709
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, APP, AR, DUSP3, EGFR, ESRRB, FABP3, FABP4, GPER1, HSP90AB1, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, SMAD3, SRC, TEK, XDH 4.70417
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, GPER1, GPR35, INSR, MET, PPARG, SMAD3 4.70417
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, AR, EGFR, ESR1, GPER1, IGF1R, INSR, MMP2, NR3C1, PPARG, SMAD3, SRC 4.68003
[BP] GO:0018212 peptidyl-tyrosine modification EGFR, HSP90AA1, IGF1R, INSR, KDR, MET, SRC, TEK 4.67637
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, CSNK2A1, EGFR, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MMP9, PPARA, SMAD3, SRC, TEK 4.67637
[BP] GO:2000147 positive regulation of cell motility APP, EGFR, GPER1, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.65063
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, SRC 4.6242
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AR, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, GPER1, HSP90AA1, HSP90AB1, IGF1R, INSR, MET, NR3C1, PGR, PPARA, PPARG, SMAD3, SRC 4.6242
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, FABP3, FABP4, FUT7, MET, PPARA, PPARG 4.62208
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AR, CYP1B1, EGFR, GPER1, GPR35, HSPA1A, INSR, KDR, MET, SRC, TEK, XDH 4.55898
[BP] GO:0051272 positive regulation of cellular component movement APP, EGFR, GPER1, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.55898
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, AR, DUSP3, EGFR, ESR1, ESR2, GPER1, GPR35, HSPA1A, IGF1R, MET, MMP9, PPARG, SMAD3, SRC, XDH 4.55898
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, AR, DUSP3, EGFR, ESR1, ESR2, GPER1, GPR35, HSPA1A, IGF1R, MET, MMP9, PPARG, SMAD3, SRC, XDH 4.54739
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, HSP90AA1, HSP90AB1, INSR, SMAD3 4.54161
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, HSP90AA1, HSP90AB1, INSR, SMAD3 4.54161
[BP] GO:1901655 None AKR1B1, AR, EGFR, NR3C1, PPARG, SRC 4.5101
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, APP, AR, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, GPER1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, PGR, PPARA, PPARG, SMAD3, SRC, TEK, XDH 4.50662
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, APP, AR, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, GPER1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, PGR, PPARA, PPARG, SMAD3, SRC, TEK, XDH 4.4681
[BP] GO:0009893 positive regulation of metabolic process ADORA1, APP, AR, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, GPER1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, PGR, PPARA, PPARG, SMAD3, SRC, TEK, XDH 4.46328
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, CA2, CYP1A1, EGFR, HSP90AA1, HSP90AB1, HSPA1A, MMP2, PPARA, PPARG, SMAD3, SRC, TEK 4.45638
[BP] GO:0040017 positive regulation of locomotion APP, EGFR, GPER1, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.45223
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, AR, CYP19A1, DUSP3, EGFR, ESR1, ESR2, GPER1, HSPA1A, IGF1R, MET, MMP9, PPARA, PPARG, SMAD3, SRC, TEK, XDH 4.44554
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, CSNK2A1, EGFR, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MMP9, SMAD3, SRC, TEK 4.4235
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, ESR1, FABP4, GPER1, PPARA, PPARG, SMAD3, TEK 4.41777
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AR, CSNK2A1, CYP1B1, EGFR, ESR1, GPER1, HSP90AB1, HSPA1A, IGF1R, KDR, MMP9, PPARG, SMAD3, SRC, TEK, XDH 4.3814
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, APP, AR, CA2, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FABP4, FUT7, HSD11B1, HSP90AB1, INSR, KDR, MET, MMP2, MMP9, PGR, PPARA, PPARG, SMAD3, SRC, TEK 4.3548
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, APP, AR, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FABP4, GPER1, GPR35, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PPARA, PPARG, SMAD3, SRC, TEK, XDH 4.32469
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AR, CA1, CA2, CSNK2A1, CYP1B1, EGFR, ESR1, ESR2, ESRRA, ESRRB, GPER1, GPR35, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PPARA, PPARG, SMAD3, SRC, TEK 4.3143
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, GPER1, HSD11B1, HSD17B1 4.3143
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 4.3143
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, HSP90AA1, HSP90AB1, INSR, SMAD3, XDH 4.31334
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALDH2, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B1, HSD17B1, PPARG, XDH 4.30072
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, EGFR, FABP3, GPER1, HSP90AB1, IGF1R, INSR, MMP2, PPARA, PPARG, SRC, TEK 4.28933
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AR, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, GPER1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, MMP9, NUAK1, PPARG, SMAD3, SRC, TEK, XDH 4.26271
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APP, AR, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPER1, GPR35, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MMP9, NR3C1, PPARA, PPARG, SMAD3, SRC, TEK, XDH 4.19655
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, ALDH2, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, EGFR, HSPA1A 4.18116
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, PPARG 4.1748
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALPL, AOX1, APP, AR, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FUT7, HSD11B1, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PPARA, PPARG, SMAD3, SRC, TEK, XDH 4.17072
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, HSP90AA1, HSP90AB1, INSR, SMAD3 4.12609
[BP] GO:0010676 None ESRRB, GPER1, INSR, PPARA, SRC 4.12609
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 4.04904
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, APP, AR, EGFR, ESRRB, FABP3, GPER1, HSP90AB1, INSR, KDR, MMP9, SMAD3, SRC, TEK, XDH 4.03532
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, APP, AR, EGFR, ESRRB, FABP3, GPER1, HSP90AB1, INSR, KDR, MMP9, SMAD3, SRC, TEK, XDH 4.03532
[BP] GO:2000377 regulation of reactive oxygen species metabolic process CYP1B1, EGFR, HSP90AA1, HSP90AB1, INSR, SMAD3, XDH 3.97269
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, EGFR, FABP3, GPER1, HSP90AB1, IGF1R, INSR, MMP2, PPARA, PPARG, SRC, TEK 3.96325
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, HSP90AA1, HSP90AB1, INSR, SMAD3 3.95411
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, GPER1, PPARA, PPARG, SMAD3, TEK 3.94894
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1 3.91503
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, APP, AR, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, GPER1, GPR35, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PPARG, SMAD3, SRC, TEK, XDH 3.90474
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.90285
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.90285
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, EGFR, GPER1, HSP90AA1, HSP90AB1, INSR, SMAD3 3.90285
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALPL, APP, AR, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FABP4, GPER1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, NUAK1, PPARA, PPARG, SMAD3, SRC, TEK 3.8994
[BP] GO:0051254 None APP, AR, EGFR, ESR1, ESR2, ESRRA, ESRRB, GPER1, HSPA1A, INSR, MET, NR3C1, PGR, PPARA, PPARG, SMAD3, SRC 3.8633
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, CSNK2A1, EGFR, HSP90AB1, HSPA1A, IGF1R, KDR, MMP9, SMAD3, SRC, TEK 3.80064
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APP, AR, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPER1, GPR35, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MMP9, NR3C1, PGR, PPARA, PPARG, SMAD3, SRC, TEK, XDH 3.80064
[BP] GO:0043408 regulation of MAPK cascade ADORA1, APP, AR, DUSP3, EGFR, GPER1, IGF1R, INSR, KDR, SRC, TEK, XDH 3.79446
[BP] GO:0042325 regulation of phosphorylation ADORA1, APP, AR, DUSP3, EGFR, ESRRB, FABP4, GPER1, HSP90AB1, IGF1R, INSR, KDR, MMP9, PPARA, SRC, TEK, XDH 3.78544
[BP] GO:0051130 positive regulation of cellular component organization APP, AR, ESR1, GPER1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PPARG, SMAD3, SRC, TEK 3.76144
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APP, AR, CSNK2A1, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, GPER1, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MMP9, NR3C1, PGR, PPARA, PPARG, SMAD3, SRC, XDH 3.76144
[BP] GO:0003006 developmental process involved in reproduction ALPL, AR, CYP19A1, EGFR, ESR1, ESRRB, HSP90AB1, INSR, PGR, PPARG, SRC 3.731
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AR, CYP19A1, CYP1A1, EGFR, ESR1, ESRRB, HSP90AB1, INSR, MMP2, MMP9, PGR, PPARG, SRC 3.69157
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, EGFR, GPER1 3.67381
[BP] GO:0045913 None ESRRB, GPER1, INSR, PPARA, SRC 3.62872
[BP] GO:0002009 morphogenesis of an epithelium AR, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 3.61807
[BP] GO:0046777 protein autophosphorylation CSNK2A1, EGFR, IGF1R, INSR, KDR, SRC, TEK 3.61426
[BP] GO:0044093 positive regulation of molecular function ADORA1, APP, AR, EGFR, ESR1, ESR2, GPER1, HSP90AA1, HSP90AB1, HSPA1A, INSR, MET, MMP9, PPARG, SMAD3, SRC, TEK, XDH 3.59912
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway EGFR, HSP90AA1, IGF1R, INSR, KDR, MET, MMP2, MMP9, SRC, TEK 3.58792
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, GPER1, MMP2, MMP9, PPARG 3.54878
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, MMP2, PPARA, PPARG, SMAD3, SRC, TEK 3.5315
[BP] GO:0031399 regulation of protein modification process ADORA1, APP, AR, DUSP3, EGFR, FABP4, GPER1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, SRC, TEK, XDH 3.5194
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, EGFR, GPER1, IGF1R, INSR, MMP2, PPARG, SRC 3.51797
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, APP, AR, EGFR, GPER1, INSR, KDR, SRC, TEK, XDH 3.51038
[BP] GO:0045893 None APP, AR, EGFR, ESR1, ESR2, ESRRA, ESRRB, GPER1, INSR, MET, NR3C1, PGR, PPARA, PPARG, SMAD3, SRC 3.50097
[BP] GO:1903508 None APP, AR, EGFR, ESR1, ESR2, ESRRA, ESRRB, GPER1, INSR, MET, NR3C1, PGR, PPARA, PPARG, SMAD3, SRC 3.50097
[BP] GO:1902680 None APP, AR, EGFR, ESR1, ESR2, ESRRA, ESRRB, GPER1, INSR, MET, NR3C1, PGR, PPARA, PPARG, SMAD3, SRC 3.49987
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, GPER1, MMP9, PPARG, SMAD3, SRC, XDH 3.49987
[BP] GO:0006631 fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PPARG 3.49571
[BP] GO:0010907 None ESRRB, INSR, PPARA, SRC 3.48681
[BP] GO:0071383 None AR, EGFR, GPER1, NR3C1, SRC 3.48681
[BP] GO:1901653 cellular response to peptide AKR1B1, APP, GPER1, IGF1R, INSR, PPARG, SRC 3.48136
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, EGFR, ESR1, FABP4, GPER1, KDR, MET, PPARA, PPARG, SMAD3, TEK 3.46732
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.46059
[BP] GO:0051896 regulation of protein kinase B signaling EGFR, GPER1, INSR, MET, SRC, TEK, XDH 3.44705
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, APP, AR, CSNK2A1, EGFR, ESR1, GPER1, HSP90AB1, HSPA1A, INSR, KDR, MMP9, PPARG, SMAD3, SRC, TEK, XDH 3.42504
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AR, CA2, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, GPER1, GPR35, HSP90AB1, HSPA1A, INSR, KDR, MET, MMP9, PPARG, SMAD3, SRC, TEK, XDH 3.40408
[BP] GO:0048545 response to steroid hormone ALPL, AR, CA2, EGFR, GPER1, NR3C1, SRC 3.35372
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 3.34103
[BP] GO:0007167 enzyme linked receptor protein signaling pathway EGFR, HSP90AA1, IGF1R, INSR, KDR, MET, MMP2, MMP9, SMAD3, SRC, TEK 3.3159
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, PPARG 3.30975
[BP] GO:1903426 None EGFR, HSP90AA1, HSP90AB1, INSR, SMAD3 3.30131
[BP] GO:0010605 negative regulation of macromolecule metabolic process APP, AR, CSNK2A1, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, GPER1, HSP90AB1, HSPA1A, IGF1R, KDR, MMP9, NR3C1, PGR, PPARA, PPARG, SMAD3, SRC, XDH 3.30131
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APP, EGFR, GPER1, IGF1R, INSR, MMP2, PPARG, SRC 3.29212
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, APP, AR, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, GPER1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PPARG, SMAD3, SRC, TEK, XDH 3.29212
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, APP, AR, EGFR, ESRRB, GPER1, HSP90AB1, INSR, KDR, MMP9, SRC, TEK, XDH 3.21165
[BP] GO:0042058 None ADORA1, APP, EGFR, GPER1, MMP9 3.20836
[BP] GO:0050678 None AR, EGFR, KDR, PGR, PPARG, SMAD3, TEK, XDH 3.20052
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APP, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, GPER1, HSP90AA1, HSP90AB1, HSPA1A, MMP2, MMP9, NUAK1, PPARA, PPARG, SMAD3, SRC, TEK 3.1887
[BP] GO:2000116 regulation of cysteine-type endopeptidase activity CSNK2A1, GPER1, MMP9, PPARG, SMAD3, SRC, XDH 3.17017
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, AR, CYP1B1, FABP3, GPER1, HSPA1A, PPARG, SMAD3, XDH 3.16738
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, CSNK2A1, CYP1B1, DUSP3, ESR1, FABP4, GPR35, IGF1R, MET, MMP9, PPARA, PPARG, SRC 3.15964
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALPL, APP, AR, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRB, FABP4, GPER1, IGF1R, INSR, MET, MMP1, MMP2, MMP9, PPARA, SMAD3, SRC, TEK 3.13113
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, APP, AR, EGFR, ESR1, GPER1, HSP90AB1, HSPA1A, INSR, KDR, MMP9, PPARG, SMAD3, SRC, TEK, XDH 3.1199
[BP] GO:0051701 interaction with host EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.11075
[BP] GO:0051098 regulation of binding APP, HSP90AB1, MET, MMP9, PPARA, PPARG, SMAD3, SRC 3.09814
[BP] GO:0032870 cellular response to hormone stimulus AR, EGFR, ESR1, GPER1, INSR, NR3C1, PPARG, SRC 3.09814
[BP] GO:0009968 negative regulation of signal transduction AR, DUSP3, EGFR, ESR1, ESR2, GPER1, HSPA1A, IGF1R, MET, MMP9, PPARG, SMAD3, SRC, XDH 3.09767
[BP] GO:0071363 cellular response to growth factor stimulus APP, EGFR, INSR, KDR, NR3C1, SMAD3, SRC 3.08402
[BP] GO:0009115 None AOX1, XDH 3.06673
[BP] GO:0022900 electron transport chain AKR1B1, ALDH2, AOX1, CYP19A1, CYP1A2, XDH 3.06422
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, ALDH2, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, HSP90AA1, HSPA1A, XDH 3.05928
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 3.05928
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, APP, AR, DUSP3, EGFR, FABP4, GPER1, HSP90AB1, IGF1R, INSR, KDR, MMP9, SRC, TEK, XDH 3.0322
[BP] GO:0042493 response to drug AKR1B1, CA9, CYP1A1, CYP1B1, EGFR, FABP3, HSP90AB1, KDR, NR3C1, PPARG, SRC 3.01305
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AR, CSNK2A1, EGFR, ESR1, GPER1, IGF1R, INSR, KDR, MMP2, MMP9, TEK 3.01259
[BP] GO:0048729 tissue morphogenesis AR, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 3.01259
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, APP, AR, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPER1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, NR3C2, NUAK1, PGR, PPARA, PPARG, SMAD3, SRC, TEK, XDH 3.00519
[BP] GO:0033559 unsaturated fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 3.00257
[BP] GO:1901184 None ADORA1, APP, EGFR, GPER1, MMP9 2.96116
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, MMP2, PPARA, SMAD3, SRC, TEK 2.95368
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, GPER1, PPARA, PPARG, SRC, TEK 2.95171
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 2.94538
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, APP, AR, CA9, CSNK2A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPER1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, NR3C2, NUAK1, PGR, PPARA, PPARG, SMAD3, SRC, TEK, XDH 2.91809
[BP] GO:0051131 None HSP90AA1, HSP90AB1, HSPA1A 2.90013
[BP] GO:0051972 regulation of telomerase activity HSP90AA1, HSP90AB1, PPARG, SRC 2.90013
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, APP, AR, CA9, CSNK2A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP4, GPER1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, NR3C2, NUAK1, PGR, PPARA, PPARG, SMAD3, SRC, TEK, XDH 2.90013
[BP] GO:0045787 positive regulation of cell cycle APP, CYP1A1, DUSP3, EGFR, GPER1, HSP90AB1, INSR, SRC 2.89593
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, MMP2, PPARA, SMAD3, SRC, TEK 2.88444
[BP] GO:0006690 icosanoid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 2.87858
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, APP, AR, CA9, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPER1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, NR3C2, NUAK1, PGR, PPARA, PPARG, SMAD3, SRC, TEK, XDH 2.86718
[BP] GO:0048608 reproductive structure development AR, CYP19A1, ESR1, HSP90AB1, INSR, PPARG, SRC 2.8629
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.8629
[BP] GO:0009611 response to wounding ACHE, ADORA3, CYP1A1, EGFR, PPARA, SMAD3 2.8629
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.8273
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade APP, DUSP3, EGFR, GPER1, KDR, SRC, TEK 2.82588
[BP] GO:0010628 positive regulation of gene expression APP, AR, EGFR, ESR1, ESR2, ESRRA, ESRRB, GPER1, HSPA1A, INSR, MET, NR3C1, PGR, PPARA, PPARG, SMAD3, SRC 2.82497
[BP] GO:0045944 None APP, AR, EGFR, ESR1, ESRRA, ESRRB, GPER1, MET, NR3C1, PGR, PPARA, PPARG, SMAD3 2.82082
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, CYP1B1, EGFR, MMP9, SRC 2.81455
[BP] GO:0051246 regulation of protein metabolic process ADORA1, APP, AR, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, GPER1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PPARG, SMAD3, SRC, TEK, XDH 2.81084
[BP] GO:0043434 None FABP3, GPER1, INSR, PPARA, PPARG, SRC, TEK 2.79386
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CYP19A1, GPER1, PPARA, PPARG, SMAD3, TEK 2.78718
[BP] GO:0070848 response to growth factor APP, EGFR, INSR, KDR, NR3C1, SMAD3, SRC 2.78718
[BP] GO:0051090 regulation of DNA binding transcription factor activity ADORA3, APP, AR, CYP1B1, ESR1, ESR2, HSPA1A, PPARG 2.78683
[BP] GO:0051052 regulation of DNA metabolic process EGFR, GPER1, HSP90AA1, HSP90AB1, IGF1R, INSR, PPARG, SRC 2.78683
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, APP, AR, EGFR, GPER1, HSP90AB1, INSR, KDR, MMP9, SRC, TEK, XDH 2.77473
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.7695
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.7695
[BP] GO:0051049 regulation of transport ACHE, ADORA1, APP, CA2, CA7, CYP19A1, EGFR, GPER1, GPR35, HSP90AB1, HSPA1A, INSR, MMP9, PPARA, PPARG, SMAD3, SRC 2.76887
[BP] GO:0035690 cellular response to drug AKR1B1, CYP1B1, EGFR, HSP90AB1, KDR, NR3C1, SRC 2.76887
[BP] GO:0080135 regulation of cellular response to stress APP, DUSP3, EGFR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, MET, NUAK1, XDH 2.7663
[BP] GO:0051172 None APP, AR, CSNK2A1, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, GPER1, HSP90AB1, HSPA1A, IGF1R, MMP9, NR3C1, PPARA, PPARG, SMAD3, SRC, XDH 2.75999
[BP] GO:1902532 negative regulation of intracellular signal transduction DUSP3, ESR1, GPER1, HSPA1A, IGF1R, MET, MMP9, SRC, XDH 2.75563
[BP] GO:0048511 rhythmic process CSNK2A1, EGFR, ESR1, PGR, PPARA, PPARG, SRC 2.75563
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, APP, AR, CA9, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPER1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, NR3C2, NUAK1, PGR, PPARA, PPARG, SMAD3, SRC, TEK, XDH 2.73599
[BP] GO:0001503 ossification ALPL, EGFR, MMP2, MMP9, TEK 2.73359
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, HSP90AB1 2.73359
[BP] GO:0052548 None APP, CSNK2A1, GPER1, MMP9, PPARG, SMAD3, SRC, XDH 2.72408
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, APP, CA2, CYP19A1, EGFR, GPER1, HSP90AB1, INSR, PPARG, SMAD3, SRC 2.72252
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, CYP1B1, EGFR, HSPA1A, MMP9, SRC 2.71131
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.69975
[BP] GO:0060748 None AR, PGR 2.69006
[BP] GO:0046110 None AOX1, XDH 2.69006
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.69006
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade APP, EGFR, GPER1, KDR, SRC, TEK 2.68152
[BP] GO:0050801 ion homeostasis APP, CA12, CA2, CA7, EGFR, ESR1, FABP3, GPER1, GPR35, SMAD3 2.68048
[BP] GO:0051128 regulation of cellular component organization APP, AR, CSNK2A1, EGFR, ESR1, ESR2, GPER1, HSP90AA1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PPARG, SMAD3, SRC, TEK 2.65654
[BP] GO:0010675 None ESRRB, GPER1, INSR, PPARA, SRC 2.63036
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, EGFR, GPER1 2.62657
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, EGFR, GPER1 2.62657
[BP] GO:0002682 regulation of immune system process ADORA1, APP, CA2, CYP19A1, DUSP3, ESR1, ESRRA, GPER1, HSP90AA1, HSP90AB1, HSPA1A, MMP2, PPARG, SMAD3, SRC 2.61265
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD17B1 2.60388
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, PPARA, PPARG, SRC, TEK 2.60357
[BP] GO:0043393 regulation of protein binding APP, HSP90AB1, MET, MMP9, PPARA, SRC 2.60247
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AR, CA2, CYP1B1, EGFR, ESRRB, GPER1, HSPA1A, KDR, MET, MMP9, PPARG, SMAD3, SRC, TEK 2.59874
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, ALDH2, AOX1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, HSP90AA1, HSPA1A, SRC, XDH 2.59363
[BP] GO:0032355 response to estradiol CYP1A2, EGFR, ESR1, ESRRA, GPER1 2.59253
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.57869
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, SRC, TEK 2.57869
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, GPER1, KDR, SRC 2.57587
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.56521
[BP] GO:0052547 None APP, CSNK2A1, GPER1, MMP9, PPARG, SMAD3, SRC, XDH 2.56364
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, CA1, CSNK2A1, EGFR, GPR35, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, MMP2, MMP9, SMAD3, SRC, TEK 2.54917
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, DUSP3, EGFR, FABP4, HSP90AA1, HSP90AB1, IGF1R, INSR, PPARG, SRC, TEK 2.54218
[BP] GO:0051336 regulation of hydrolase activity APP, CSNK2A1, EGFR, ESR1, GPER1, HSP90AB1, HSPA1A, MMP9, NUAK1, PPARG, SMAD3, SRC, XDH 2.53707
[BP] GO:0051054 positive regulation of DNA metabolic process EGFR, HSP90AA1, HSP90AB1, IGF1R, INSR, SRC 2.52819
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.51393
[BP] GO:1900182 positive regulation of protein localization to nucleus APP, EGFR, HSP90AB1, SMAD3, SRC 2.5127
[BP] GO:0010632 regulation of epithelial cell migration KDR, MET, MMP9, PPARG, SRC, TEK 2.51114
[BP] GO:0010038 response to metal ion APP, CA2, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.49932
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, KDR, MMP2, PPARG, SRC 2.47661
[BP] GO:0010629 None APP, AR, ESR1, ESR2, ESRRA, FABP4, GPER1, HSPA1A, KDR, NR3C1, PGR, PPARA, PPARG, SMAD3, SRC, XDH 2.47661
[BP] GO:1901360 None ACHE, AKR1B1, AKR1B10, AOX1, APP, AR, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, HSD11B1, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, NR3C1, NR3C2, PGR, PPARA, PPARG, SMAD3, XDH 2.47471
[BP] GO:0051894 None KDR, SMAD3, TEK 2.47471
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1 2.47471
[BP] GO:0035902 response to immobilization stress CYP1A1, CYP1A2, PPARG 2.47471
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.47471
[BP] GO:0010556 regulation of macromolecule biosynthetic process ADORA3, APP, AR, CA9, CSNK2A1, CYP1B1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP4, GPER1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NR3C1, NR3C2, PGR, PPARA, PPARG, SMAD3, SRC 2.47098
[BP] GO:1905323 None HSP90AA1, HSP90AB1 2.45791
[BP] GO:0006145 None AOX1, XDH 2.45791
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.45791
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.45791
[BP] GO:0031324 negative regulation of cellular metabolic process APP, AR, CSNK2A1, DUSP3, ESR1, ESR2, ESRRA, FABP4, GPER1, HSP90AB1, HSPA1A, IGF1R, MET, MMP9, NR3C1, PPARA, PPARG, SMAD3, SRC, XDH 2.45682
[BP] GO:0050793 regulation of developmental process APP, AR, CA2, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, GPER1, HSP90AB1, INSR, KDR, NUAK1, PPARA, PPARG, SMAD3, SRC, TEK, XDH 2.42142
[BP] GO:0032868 None FABP3, INSR, PPARA, PPARG, SRC 2.40365
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, APP, EGFR, ESR1, GPER1, HSP90AA1, HSP90AB1, HSPA1A, INSR, PPARG, SMAD3, SRC, TEK, XDH 2.39686
[BP] GO:1903393 None KDR, SMAD3, TEK 2.38493
[BP] GO:0009889 regulation of biosynthetic process ADORA3, APP, AR, CA9, CSNK2A1, CYP1B1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPER1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NR3C1, NR3C2, PGR, PPARA, PPARG, SMAD3, SRC 2.37049
[BP] GO:0043627 response to estrogen CA2, ESR1, PPARG, TEK 2.35811
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, CYP1B1, EGFR, HSPA1A, MMP9, SRC 2.33537
[BP] GO:0051248 None APP, CSNK2A1, DUSP3, EGFR, FABP4, GPER1, HSP90AB1, HSPA1A, IGF1R, MMP9, SMAD3, SRC, XDH 2.32401
[BP] GO:0009894 regulation of catabolic process ADORA1, CSNK2A1, EGFR, ESRRB, HSP90AB1, HSPA1A, INSR, KDR, MET, PPARA, SMAD3 2.31603
[BP] GO:0051094 positive regulation of developmental process APP, AR, CA2, CYP1B1, ESRRB, GPER1, HSP90AB1, INSR, KDR, PPARG, SMAD3, SRC, TEK 2.31603
[BP] GO:0046320 None FABP3, PPARA, PPARG 2.29848
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9 2.29848
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.29097
[BP] GO:0008217 None ADORA1, AR, PPARA, PPARG, SMAD3 2.27839
[BP] GO:0010638 positive regulation of organelle organization GPER1, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 2.2761
[BP] GO:0048732 gland development AR, CSNK2A1, CYP19A1, EGFR, INSR, SMAD3 2.27502
[BP] GO:0032787 None CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PPARG 2.26764
[BP] GO:0051091 positive regulation of DNA binding transcription factor activity APP, AR, ESR1, ESR2, HSPA1A, PPARG 2.26764
[BP] GO:0032800 receptor biosynthetic process ACHE, PPARG 2.2673
[BP] GO:0010891 None PPARA, PPARG 2.2673
[BP] GO:0071396 cellular response to lipid AR, EGFR, ESR1, GPER1, NR3C1, PPARG, SRC 2.2543
[BP] GO:0051897 positive regulation of protein kinase B signaling EGFR, INSR, MET, SRC, TEK 2.24979
[BP] GO:0006468 protein phosphorylation APP, CSNK2A1, EGFR, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, SRC, TEK 2.24306
[BP] GO:0044089 positive regulation of cellular component biogenesis ESR1, HSPA1A, KDR, MET, MMP1, SMAD3, SRC, TEK 2.2347
[BP] GO:2000112 regulation of cellular macromolecule biosynthetic process ADORA3, APP, AR, CA9, CSNK2A1, CYP1B1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP4, GPER1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, MET, NR3C1, NR3C2, PGR, PPARA, PPARG, SMAD3, SRC 2.23169
[BP] GO:1903076 None AR, CSNK2A1, EGFR, GPER1 2.23111
[BP] GO:0019219 regulation of nucleobase-containing compound metabolic process ADORA3, APP, AR, CA9, CSNK2A1, CYP1B1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP4, GPER1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, MET, NR3C1, NR3C2, PGR, PPARA, PPARG, SMAD3, SRC 2.23104
[BP] GO:0035265 organ growth AR, CYP19A1, ESR1 2.23104
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.23104
[BP] GO:0031960 response to corticosteroid ALPL, EGFR, GPER1, NR3C1, SRC 2.22408
[BP] GO:1901568 fatty acid derivative metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 2.22408
[BP] GO:0003018 None ADORA1, EGFR, GPER1, SRC, TEK 2.22408
[BP] GO:0043255 regulation of carbohydrate biosynthetic process ESRRB, GPER1, INSR, PPARA 2.22075
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, PPARG 2.20582
[BP] GO:1901888 regulation of cell junction assembly KDR, SMAD3, SRC, TEK 2.20582
[BP] GO:1901890 None KDR, SMAD3, TEK 2.20411
[BP] GO:0071276 cellular response to cadmium ion CYP1A2, EGFR, MMP9 2.20411
[BP] GO:0098771 inorganic ion homeostasis APP, CA12, CA2, CA7, EGFR, ESR1, GPER1, GPR35, SMAD3 2.17146
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7 2.16571
[BP] GO:0009653 anatomical structure morphogenesis APP, AR, CA2, CA9, CYP1B1, EGFR, ESR1, INSR, MET, MMP2, SMAD3, SRC, TEK 2.16567
[BP] GO:0031326 regulation of cellular biosynthetic process ADORA3, APP, AR, CA9, CSNK2A1, CYP1B1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPER1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, MET, NR3C1, NR3C2, PGR, PPARA, PPARG, SMAD3, SRC 2.15104
[BP] GO:0051099 positive regulation of binding APP, HSP90AB1, MET, MMP9, PPARG 2.13971
[BP] GO:0106027 None APP, IGF1R, INSR 2.13842
[BP] GO:0010887 None PPARA, PPARG 2.13842
[BP] GO:0010871 None PPARA, PPARG 2.13842
[BP] GO:0046113 None AOX1, XDH 2.13842
[BP] GO:1990535 None APP, INSR 2.13842
[BP] GO:0040008 regulation of growth APP, AR, CSNK2A1, EGFR, ESR2, HSPA1A, INSR, PPARG, SMAD3 2.13482
[BP] GO:0009895 negative regulation of catabolic process ADORA1, EGFR, HSP90AB1, MET, PPARA, SMAD3 2.13286
[BP] GO:1904375 None AR, CSNK2A1, EGFR, GPER1 2.11359
[BP] GO:0051726 regulation of cell cycle APP, CSNK2A1, CYP1A1, DUSP3, EGFR, GPER1, HSP90AA1, HSP90AB1, HSPA1A, INSR, SMAD3, SRC 2.08195
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APP, CSNK2A1, DUSP3, EGFR, HSP90AA1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, SRC, TEK, XDH 2.07983
[BP] GO:0071392 None EGFR, ESR1, GPER1 2.07345
[BP] GO:0006357 None APP, AR, CA9, EGFR, ESR1, ESR2, ESRRA, ESRRB, GPER1, HSPA1A, MET, NR3C1, PGR, PPARA, PPARG, SMAD3 2.07164
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AR, CYP1A1, EGFR, ESR1, ESRRB, FABP4, FUT7, KDR, MET, MMP2, MMP9, PGR, PPARG, SMAD3, SRC, TEK 2.0627
[BP] GO:0071241 cellular response to inorganic substance CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.05564
[BP] GO:0045124 None CA2, EGFR, SRC 2.04191
[BP] GO:0045862 positive regulation of proteolysis APP, GPER1, HSPA1A, PPARG, SMAD3, SRC, XDH 2.03749
[BP] GO:0006109 regulation of carbohydrate metabolic process ESRRB, GPER1, INSR, PPARA, SRC 2.03749
[BP] GO:0000302 response to reactive oxygen species AKR1B1, CYP1B1, EGFR, MMP9, SRC 2.03749
[BP] GO:0010952 None APP, GPER1, PPARG, SMAD3, XDH 2.03749
[BP] GO:0035295 tube development AKR1B1, AR, CYP1A1, EGFR, SMAD3 2.02694
[BP] GO:0030162 regulation of proteolysis APP, CSNK2A1, GPER1, HSP90AB1, HSPA1A, MMP9, PPARG, SMAD3, SRC, XDH 2.02279
[BP] GO:0045742 None ADORA1, GPER1, MMP9 2.01658
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, HSP90AB1, TEK 3.75063
[CC] GO:0031253 None ADORA1, CA4, CA9, GPER1, HSP90AA1, HSP90AB1, INSR, SRC 3.32766
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, EGFR, GPER1, HSP90AA1, HSP90AB1, INSR, MET, SRC, TEK 2.66888
[CC] GO:0043235 receptor complex APP, EGFR, HSP90AB1, IGF1R, INSR, NR3C2, SMAD3 2.47661
[CC] GO:0031256 None ADORA1, GPER1, HSP90AA1, INSR, SRC 2.2609
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, AOX1, APP, AR, CA1, CA2, CA4, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FUT7, GPER1, HSD11B1, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, INSR, KDR, MMP2, MMP9, NR3C1, NR3C2, PGR, PPARG, SMAD3, SRC, XDH 2.21117
[CC] GO:0048471 perinuclear region of cytoplasm ACHE, AKR1B1, APP, CA4, EGFR, GPER1, HSPA1A, PPARG, SRC 2.15564
[MF] GO:0046914 transition metal ion binding AOX1, APP, AR, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, NR3C1, NR3C2, PGR, PPARA, PPARG, SMAD3, XDH 16.4441
[MF] GO:0003707 steroid hormone receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, NR3C1, NR3C2, PGR, PPARA, PPARG 12.7481
[MF] GO:0005496 steroid binding AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, HSD17B1, NR3C1, NR3C2, PGR, SHBG 11.0088
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.3809
[MF] GO:0043167 ion binding ACHE, ALPL, AOX1, APP, AR, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PPARA, PPARG, SMAD3, SRC, TEK, XDH 10.2977
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PGR, PPARA, PPARG 10.2776
[MF] GO:0004879 nuclear receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PGR, PPARA, PPARG 10.2776
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, NR3C1, NR3C2, PGR, PPARA, PPARG, SMAD3 9.78236
[MF] GO:0042562 hormone binding ACHE, AR, EGFR, GPER1, HSD17B1, IGF1R, INSR, NR3C1, SHBG 8.3871
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.98557
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.71473
[MF] GO:0008289 lipid binding AR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPER1, HSD17B1, NR3C1, NR3C2, PGR, PPARA, PPARG, SHBG 6.29519
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AR, EGFR, ESR1, ESR2, ESRRA, ESRRB, GPER1, GPR35, IGF1R, INSR, KDR, MET, NR3C1, NR3C2, PGR, PPARA, PPARG, TEK 6.16589
[MF] GO:0030235 nitric-oxide synthase regulator activity EGFR, ESR1, HSP90AA1, HSP90AB1 5.93433
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.93433
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 5.5738
[MF] GO:0043169 cation binding ACHE, ALPL, AOX1, APP, AR, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PPARA, PPARG, SMAD3, XDH 5.5738
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AR, EGFR, ESR1, ESR2, ESRRA, ESRRB, GPER1, GPR35, IGF1R, INSR, KDR, MET, NR3C1, NR3C2, PGR, PPARA, PPARG, SMAD3, TEK 5.42177
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AR, EGFR, ESR1, ESR2, ESRRA, ESRRB, GPER1, GPR35, IGF1R, INSR, KDR, MET, NR3C1, NR3C2, PGR, PPARA, PPARG, TEK 5.3805
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, FUT7, HSD11B1, HSD17B1, HSP90AA1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, SRC, TEK, XDH 5.37943
[MF] GO:0046872 metal ion binding ALPL, AOX1, APP, AR, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PPARA, PPARG, SMAD3, XDH 5.19652
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AR, EGFR, ESR1, ESR2, ESRRA, ESRRB, GPER1, GPR35, IGF1R, INSR, KDR, MET, NR3C1, NR3C2, PGR, PPARA, PPARG, TEK 5.17718
[MF] GO:0005506 iron ion binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, XDH 5.07567
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity EGFR, IGF1R, INSR, KDR, MET, TEK 5.01903
[MF] GO:0008144 drug binding ACHE, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, EGFR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PPARA, PPARG, SRC, TEK 4.76535
[MF] GO:0004713 protein tyrosine kinase activity EGFR, HSP90AA1, IGF1R, INSR, KDR, MET, SRC, TEK 4.76535
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC 4.6242
[MF] GO:0019199 transmembrane receptor protein kinase activity EGFR, IGF1R, INSR, KDR, MET, TEK 4.55898
[MF] GO:0048037 cofactor binding ALDH2, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, SRC, XDH 4.47772
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC 4.45768
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALDH2, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B1, HSD17B1, XDH 4.44978
[MF] GO:0016903 None AKR1B1, AKR1B10, ALDH2, AOX1, XDH 4.42597
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 4.38672
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2, GPER1 4.34751
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 4.19002
[MF] GO:0032403 protein complex binding ACHE, ADORA1, EGFR, ESRRB, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MMP9, PPARA, SMAD3, SRC 4.10889
[MF] GO:0097159 organic cyclic compound binding ADORA1, ALDH2, AOX1, APP, AR, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ESR1, ESR2, ESRRA, ESRRB, GPER1, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NR3C1, NR3C2, NUAK1, PGR, PPARA, PPARG, SHBG, SMAD3, SRC, TEK, XDH 4.03532
[MF] GO:0019899 enzyme binding APP, AR, CYP1A1, CYP1A2, CYP2A6, DUSP3, EGFR, ESR1, ESR2, ESRRB, HSP90AA1, HSP90AB1, HSPA1A, MET, NR3C1, PGR, PPARA, PPARG, SMAD3, SRC, TEK 4.01713
[MF] GO:0031072 heat shock protein binding ADORA1, CSNK2A1, HSP90AB1, HSPA1A, KDR, NR3C1 3.97269
[MF] GO:0009055 electron transfer activity AKR1B1, ALDH2, AOX1, CYP19A1, CYP1A2, XDH 3.91503
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, EGFR, ESRRB, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MMP9, PPARA, SMAD3, SRC 3.87644
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.77416
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.57904
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6 3.44614
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD11B1, HSD17B1, XDH 3.43558
[MF] GO:0042802 identical protein binding ACHE, AOX1, APP, CSNK2A1, EGFR, ESR1, ESR2, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP9, PGR, PPARG, SMAD3, XDH 3.40408
[MF] GO:1901363 heterocyclic compound binding ADORA1, ALDH2, AOX1, APP, AR, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NR3C1, NR3C2, NUAK1, PGR, PPARA, PPARG, SMAD3, SRC, TEK, XDH 3.20836
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 3.15249
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 3.06673
[MF] GO:0008389 None CYP2A13, CYP2A6 3.06673
[MF] GO:0000981 None AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, NR3C1, PGR, PPARA, PPARG, SMAD3 2.90013
[MF] GO:0036094 small molecule binding ADORA1, ALDH2, AOX1, CSNK2A1, EGFR, FABP3, FABP4, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PPARG, SRC, TEK, XDH 2.88377
[MF] GO:0000978 None AR, ESR1, ESR2, ESRRA, NR3C1, PGR, PPARA, SMAD3 2.75534
[MF] GO:0004672 protein kinase activity CSNK2A1, EGFR, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, SRC, TEK 2.75149
[MF] GO:0000987 None AR, ESR1, ESR2, ESRRA, NR3C1, PGR, PPARA, SMAD3 2.64279
[MF] GO:0003690 None AR, EGFR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, PGR, PPARA, PPARG, SMAD3 2.64279
[MF] GO:0019904 None APP, AR, ESRRA, HSP90AA1, HSP90AB1, HSPA1A, INSR, PPARA, PPARG, SRC 2.57191
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.5127
[MF] GO:0000976 None AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, PGR, PPARA, PPARG, SMAD3 2.50907
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.45791
[MF] GO:0005497 None AR, SHBG 2.45791
[MF] GO:0051425 None APP, INSR 2.45791
[MF] GO:1990837 None AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, PGR, PPARA, PPARG, SMAD3 2.36094
[MF] GO:0005504 None FABP3, FABP4, PPARG 2.33985
[MF] GO:0043559 insulin binding IGF1R, INSR 2.2673
[MF] GO:0001012 None AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, PGR, PPARA, SMAD3 2.22885
[MF] GO:0000977 None AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, PGR, PPARA, SMAD3 2.22885
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor CSNK2A1, EGFR, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, SRC, TEK 2.21446
[MF] GO:0008013 beta-catenin binding AR, CSNK2A1, ESR1, SMAD3 2.20582
[MF] GO:0097718 None HSP90AA1, HSP90AB1, HSPA1A 2.20411
[MF] GO:0051879 Hsp90 protein binding CSNK2A1, KDR, NR3C1 2.16571
[MF] GO:1990239 None GPER1, NR3C1 2.13842
[MF] GO:0050543 None FABP3, PPARG 2.13842
[MF] GO:0004064 arylesterase activity CA1, CA2 2.13842
[MF] GO:0043546 None AOX1, XDH 2.13842
[MF] GO:0019902 phosphatase binding EGFR, MET, PPARA, PPARG, SMAD3 2.13836
[MF] GO:0035258 None ESR1, PPARG, SMAD3, SRC 2.11359
[MF] GO:0001047 None ESR1, ESR2, ESRRB, NR3C1, PPARG 2.0948
[MF] GO:0005102 receptor binding ADORA1, APP, AR, EGFR, ESR1, ESR2, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, PPARG, SMAD3, SRC 2.08764
[MF] GO:0001077 None AR, ESR1, ESRRA, NR3C1, PGR, PPARA 2.05564
[MF] GO:0044212 None AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, PGR, PPARA, PPARG, SMAD3 2.01964
[MF] GO:0001609 None ADORA1, ADORA3 2.01771
[MF] GO:0001067 None AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, PGR, PPARA, PPARG, SMAD3 2.01754


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Estrogen signaling pathway_Homo sapiens_hsa04915 HSP90AA1, HSP90AB1, SRC, MMP2, GPER1, MMP9, ESR1, EGFR, ESR2, HSPA1A 10.7637
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.4857
Adherens junction_Homo sapiens_hsa04520 SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 7.0518
Pathways in cancer_Homo sapiens_hsa05200 AR, HSP90AA1, SMAD3, HSP90AB1, MMP1, MMP2, PPARG, MMP9, MET, EGFR, IGF1R 6.4013
Ovarian steroidogenesis_Homo sapiens_hsa04913 INSR, HSD17B1, CYP1A1, CYP1B1, CYP19A1, IGF1R 6.6236
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.4013
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, EGFR, IGF1R 5.7533
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 5.8589
Tryptophan metabolism_Homo sapiens_hsa00380 ALDH2, CYP1A2, CYP1A1, AOX1, CYP1B1 5.7533
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.7533
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 5.7508
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, MET, EGFR, IGF1R 4.5852
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 HSP90AA1, HSP90AB1, INSR, KDR, TEK, MET, EGFR, IGF1R 4.2644
Prostate cancer_Homo sapiens_hsa05215 AR, HSP90AA1, HSP90AB1, EGFR, IGF1R 4.2644
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 4.0849
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARG, PPARA 4.7279
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, CYP19A1, HSD11B1, CYP2A6, FUT7, AKR1B10, ALDH2, HSD17B1, CYP1A2, CYP1A1, AOX1, ALPL, XDH 3.4859
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, TEK, MET, EGFR, IGF1R 3.4451
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1 3.5167
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 HSP90AA1, HSP90AB1, PGR, IGF1R 2.9076
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, EGFR, IGF1R 2.7464
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, TEK, EGFR, IGF1R 2.8438
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 2.4751
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1 2.4768
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.3562
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, ALDH2, AKR1B1 2.4436
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.2947
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.2692
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.2654
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 PPARG, MMP9, MET, IGF1R 2.1045
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2, AOX1 2.291
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 2.0245
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, ALDH2, AKR1B1 2.9722
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, PPARG, IGF1R 1.9965
Antigen processing and presentation_Homo sapiens_hsa04612 HSP90AA1, HSP90AB1, HSPA1A 2.1946
Oocyte meiosis_Homo sapiens_hsa04114 AR, PGR, IGF1R 1.7047
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, PPARG, IGF1R 1.7047
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GPR35, ADORA3, ADORA1, NR3C1 1.569
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, ESRRB, IGF1R 1.5719
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, MMP9 1.5677
MicroRNAs in cancer_Homo sapiens_hsa05206 CYP1B1, MMP9, MET, EGFR 1.487
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1 1.4369
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSP90AA1, HSP90AB1, HSPA1A 1.4316
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, HSPA1A 1.0532
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2 1.083
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 KDR, MET, EGFR 1.0321
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 1.1802
Insulin resistance_Homo sapiens_hsa04931 INSR, PPARA 1.0436
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.3784
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.9108
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.1677
Gap junction_Homo sapiens_hsa04540 SRC, EGFR 1.1784
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 1.0014
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.9219
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.4225
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.374
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.8901
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.0014
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.9948
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, EGFR 0.8857
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2609
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.8614
Central carbon metabolism in cancer_Homo sapiens_hsa05230 MET, EGFR 1.3696
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9003
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 0.8554
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 HSP90AA1, HSP90AB1 1.453
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, HSPA1A 0.727
cAMP signaling pathway_Homo sapiens_hsa04024 ADORA1, PPARA 0.7328
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.7005
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 ALDH2, AOX1 1.569
HTLV-I infection_Homo sapiens_hsa05166 SMAD3 0.2761
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.5754
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3434
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3748
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3675
Huntington's disease_Homo sapiens_hsa05016 PPARG 0.3598
Calcium signaling pathway_Homo sapiens_hsa04020 EGFR 0.3736
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3742
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR, NR3C2 1.7047
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.3748
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.384
Jak-STAT signaling pathway_Homo sapiens_hsa04630 AOX1 0.4018
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.4096
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3671
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.4496
Insulin signaling pathway_Homo sapiens_hsa04910 INSR 0.44
Osteoclast differentiation_Homo sapiens_hsa04380 PPARG 0.4517
Platelet activation_Homo sapiens_hsa04611 SRC 0.4701
Cell cycle_Homo sapiens_hsa04110 SMAD3 0.4675
Axon guidance_Homo sapiens_hsa04360 MET 0.4622
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4944
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.4944
Toxoplasmosis_Homo sapiens_hsa05145 HSPA1A 0.4787
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.5114
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.5188
Serotonergic synapse_Homo sapiens_hsa04726 APP 0.4944
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5188
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.523
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5274
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5363
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5271
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.5318
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5415
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.5555
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5411
Peroxisome_Homo sapiens_hsa04146 XDH 0.5563
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.5983
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5969
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8854
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6066
Bile secretion_Homo sapiens_hsa04976 CA2 0.605
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.6216
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6236
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6385
Shigellosis_Homo sapiens_hsa05131 SRC 0.6236
Colorectal cancer_Homo sapiens_hsa05210 SMAD3 0.6297
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3 0.6236
Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 ALDH2 0.6198
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.6617
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.6828
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8413
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6645
Lysine degradation_Homo sapiens_hsa00310 ALDH2 0.6828
Malaria_Homo sapiens_hsa05144 MET 0.6931
Arginine and proline metabolism_Homo sapiens_hsa00330 ALDH2 0.6895
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.7005
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.697
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0793
Fatty acid degradation_Homo sapiens_hsa00071 ALDH2 0.7183
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7926
Pyruvate metabolism_Homo sapiens_hsa00620 ALDH2 0.7426
Thyroid cancer_Homo sapiens_hsa05216 PPARG 0.8502
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8586
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1 0.7926
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8327
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8502
beta-Alanine metabolism_Homo sapiens_hsa00410 ALDH2 0.8327
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8502
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8586
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8586
Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 ALDH2 0.8586
Histidine metabolism_Homo sapiens_hsa00340 ALDH2 0.8794
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.5552
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0436
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3494


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)