TCM Prescription: Nuan Gong Yun Zi Pills



Prescription Description
Prescription IDTCMF4357
Pinyin NameNuan Gong Yun Zi Wan
Chinese Name暖宫孕子丸
English NameNuan Gong Yun Zi Pills
Function Description痛经, 带下病, 不孕
IndicationsDysmenorrhea disorder, Leukorrhea disorder, Infertility disorder, Infertility, Dysmenorrhea
Disease ICD-11 Category SB96 [Dysmenorrhea disorder (TM1), 痛经 (TM1) ];
SC20 [Leukorrhea disorder (TM1), 带下病 (TM1) ];
SC22 [Infertility disorder (TM1), 不孕 (TM1) ];
GA31 [Female infertility, 女性不孕症 ];
GA34.3 [Dysmenorrhoea, 痛经 ];
Human Tissues Associated with IndicationUterus, Liver, Kidney
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1966 Rehmannia glutinosa 熟地黄 TCMH1966 ITSAH4578-14
TCMH2265 Cyperus rotundus 香附 TCMH2265 GENG1049-15
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH541 Colla corii asini 阿胶 TCMH541
TCMH12 Artemisia argyi 艾叶 TCMH12 ITSAE2504-14
TCMH524 Eucommia ulmoides 杜仲 TCMH524 ITSAM1588-14
TCMH2334 Dipsacus japonicus 续断 TCMH2334 ITSAC1509-14
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT248 CXCL8 Interleukin-8 Unclassified P10145
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT287 TAS2R31 Taste receptor type 2 member 31 GPCR P59538
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1319 Corynebacterium xerosis
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1354 Streptococcus mutans UA159
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 12.4838
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FUT7, PIM1, PPARA, PTGS1, PTGS2, TYR, XDH 11.6662
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.6035
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, PPARA, PTGS1, PTGS2 10.3884
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 10.0078
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 9.30816
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 9.03272
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 8.44586
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 7.63472
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 7.40136
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, F10, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS1, PTGS2, PTPRS, RORC, SRC, TNKS, TNKS2, TYR, XDH 7.32253
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PTGS1, PTGS2 7.15788
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, FUT7, MET, PPARA, PTGS1, PTGS2 6.70852
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 6.68369
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, F10, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, PIM1, PPARA, PTGS1, PTGS2, PTPRS, RORC, SRC, TNKS, TNKS2, TYR, XDH 6.63344
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AXL, CA9, CSNK2A1, CXCL8, CYP1A1, CYP1A2, CYP1B1, FABP3, HSD17B2, IGF1R, MMP2, MMP9, PPARA, PTGS2, RORC, SRC, TYR 6.52607
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, HSD17B2, PTGS1, PTGS2, TYR, XDH 6.34464
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, FLT3, HCAR2, KDR, MET, MMP12, MMP9, PTGS2, SRC, TNKS, TNKS2, XDH 6.28193
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, APP, AXL, CA2, CA9, CSNK2A1, CXCL8, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, PPARA, PTGS2, RORC, SRC, TYR 6.28193
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, FLT3, HCAR2, KDR, MET, MMP12, MMP9, PTGS2, SRC, TNKS, TNKS2, XDH 6.28193
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, PTGS2, SRC 6.28193
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, ALOX15, ALPL, APP, AXL, CA2, CA9, CSNK2A1, CXCL8, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, MMP9, PPARA, PTGS2, RORC, SRC, TYR 5.92049
[BP] GO:0033993 response to lipid ALPL, AXL, CA2, CA9, CSNK2A1, CXCL8, CYP1A1, CYP1A2, FABP3, FLT3, HSD17B2, PTGS2, RORC, SRC, TYR 5.9027
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, F10, FABP3, FABP4, FLT3, HCAR2, HSD17B1, HSD17B2, KDR, MET, PPARA, PTGS1, PTGS2, SRC, TNKS, TNKS2, XDH 5.87733
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, HSD17B1, HSD17B2 5.80235
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.68177
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 5.50669
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PTGS1, PTGS2 5.15056
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APP, CA2, CA9, CSNK2A1, CXCL8, CYP1A2, FABP3, FLT3, IGF1R, MMP2, PPARA, PTGS2, SRC 4.18443
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, CSNK2A1, CXCL8, CYP1B1, FABP3, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTGS1, PTGS2, SRC, XDH 4.17044
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PIM1, PPARA, PTGS1, PTGS2, TYR 4.11343
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FLT3, PTGS2, RORC, SRC, TYR 4.11343
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, APP, AXL, CXCL8, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, PTGS2, RORC, SRC 4.09773
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, CA2, CA9, CBR1, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, FUT7, HSD17B2, KDR, MET, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPRS, RORC, SRC, TNKS2, TYR 3.99729
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AXL, CSNK2A1, CYP1B1, F10, FLT3, KDR, MET, MMP12, MMP9, PTGS2, SRC, TNKS, TNKS2, XDH 3.99686
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CXCL8, CYP19A1, CYP1B1, F10, FLT3, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, PTGS2, PTPRS, SRC, TNKS, TNKS2, XDH 3.92214
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, CXCL8, CYP19A1, CYP1B1, F10, IGF1R, KDR, MET, MMP9, PTGS2, SRC 3.85502
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, APP, AXL, CXCL8, CYP1A1, CYP1B1, FABP4, FLT3, IGF1R, KDR, MMP2, PTGS2, RORC, SRC 3.85502
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CXCL8, CYP19A1, CYP1B1, F10, FLT3, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, PTGS2, PTPRS, SRC, TNKS, TNKS2, XDH 3.83581
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AXL, CYP19A1, CYP1A2, CYP1B1, F10, FABP4, HSD17B2, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, RORC, SRC, TNKS2, TYR 3.74367
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1B1, F10, FABP3, FLT3, HCAR2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, RORC, SRC, TNKS, TNKS2, XDH 3.70405
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PIM1, PPARA, PTGS1, PTGS2, TYR 3.68163
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, APP, AXL, CSNK2A1, CXCL8, CYP1B1, F10, FABP4, FLT3, KDR, MET, MMP12, MMP2, MMP9, PTGS2, SRC, TNKS, TNKS2, XDH 3.68163
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PIM1, PPARA, PTGS1, PTGS2, TYR 3.60371
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.60371
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, CXCL8, CYP19A1, CYP1B1, F10, IGF1R, KDR, MET, MMP9, PTGS2, SRC 3.60066
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, ALOX15, APP, AXL, CA2, CA7, CSNK2A1, CXCL8, CYP19A1, CYP1B1, F10, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTGS2, SRC 3.57199
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.5657
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, MMP1, MMP12, MMP2, MMP9, SRC, XDH 3.56314
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.56314
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.56314
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, CA2, CA6, CA9, CSNK2A1, CXCL8, CYP1A1, CYP1A2, CYP1B1, F10, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP12, MMP2, MMP9, PPARA, PTGS1, PTGS2, RORC, SRC, TYR 3.56084
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, PTGS1, RORC 3.46427
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, HCAR2, PPARA, PTGS2, RORC, SRC 3.43948
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.42438
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, HCAR2, KDR, PTGS2, SRC, TNKS, TNKS2 3.42356
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1B1, F10, FABP3, FABP4, FLT3, HCAR2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, RORC, SRC, TNKS, TNKS2, XDH 3.41557
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, FLT3, HSD17B2, KDR, PPARA, PTPRS, SRC, TYR 3.37022
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, CXCL8, CYP19A1, CYP1B1, F10, IGF1R, KDR, MET, MMP9, PTGS2, SRC 3.29985
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, CXCL8, CYP19A1, CYP1B1, F10, IGF1R, KDR, MET, MMP9, PTGS2, SRC 3.2953
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AXL, CA2, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, HSD17B2, KDR, MMP9, PIM1, PPARA, PTGS2, PTPRS, RORC, SRC, TYR 3.2953
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.2953
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.10897
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.10897
[BP] GO:0009725 response to hormone AKR1B1, ALPL, CA2, CA9, CSNK2A1, CYP1A2, FABP3, FLT3, PPARA, PTGS2, SRC 3.05051
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTGS2, SRC 3.02996
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, HCAR2, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTGS2, SRC, XDH 3.02187
[BP] GO:0019371 None CBR1, PTGS1, PTGS2 3.00596
[BP] GO:0046456 icosanoid biosynthetic process ALOX15, ALOX5, PTGS1, PTGS2 2.97843
[BP] GO:0010038 response to metal ion ALOX15, APP, CA2, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.95945
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, HCAR2, PTGS2, TNKS, TNKS2 2.94486
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AXL, CYP1B1, F10, FLT3, KDR, MET, PTGS2, SRC, XDH 2.94022
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, HSD17B1, HSD17B2, PTGS1, PTGS2 2.93534
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.92671
[BP] GO:0030335 positive regulation of cell migration APP, CXCL8, F10, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.86173
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, SRC, TNKS 2.82923
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, HCAR2, IGF1R, KDR, MET, MMP9, PIM1, PTGS2, SRC, XDH 2.82756
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.81375
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, CYP1B1, MMP9, PTGS1, PTGS2, SRC 2.77276
[BP] GO:2000147 positive regulation of cell motility APP, CXCL8, F10, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.76309
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, IGF1R, KDR, MET, MMP9, PIM1, PTGS2, SRC 2.75295
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, CYP1A1, CYP1B1, FLT3, PTGS2, RORC, SRC 2.72027
[BP] GO:0051272 positive regulation of cellular component movement APP, CXCL8, F10, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.68598
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, F10, FABP3, FABP4, FLT3, FUT7, HCAR2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS1, PTGS2, PTPRS, RORC, SRC, TNKS, TNKS2, TUBB3, TYR, XDH 2.68114
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.61088
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AXL, CXCL8, CYP1B1, IGF1R, MMP2, MMP9, PTGS2, RORC, SRC 2.6062
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, CA2, CA9, CXCL8, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, PTGS2, RORC, SRC 2.60209
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CSNK2A1, CXCL8, CYP19A1, CYP1B1, F10, FABP4, FLT3, IGF1R, KDR, MET, MMP12, MMP2, MMP9, PPARA, PTGS2, PTPRS, SRC, TNKS, TNKS2, XDH 2.58634
[BP] GO:0040017 positive regulation of locomotion APP, CXCL8, F10, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.58634
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.5843
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, F10, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS1, PTGS2, PTPRS, RORC, SRC, TNKS, TNKS2, TYR, XDH 2.54289
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.54289
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP1B1, F10, FLT3, IGF1R, KDR, MET, MMP9, PTGS2, SRC, XDH 2.54289
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.51908
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, CBR1, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, F10, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS1, PTGS2, PTPRS, RORC, SRC, TNKS, TNKS2, TYR, XDH 2.50137
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.49973
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CXCL8, CYP1A1, CYP1A2, PTGS2, SRC 2.48921
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.48074
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HCAR2, HSD17B1, HSD17B2 2.48074
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.4761
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.44022
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.35554
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, HCAR2, IGF1R, KDR, MMP9, PIM1, PTGS2, SRC, XDH 2.3432
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CXCL8, CYP1A1, CYP1A2, PTGS2, SRC 2.33145
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, PTGS2 2.3009
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, APP, CYP19A1, CYP1A1, CYP1B1, TYR 2.3009
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.30074
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.28496
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.2804
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PTGS2, SRC 2.2804
[BP] GO:0043393 regulation of protein binding APP, AURKB, MET, MMP9, PPARA, SRC 2.2804
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC 2.25299
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.25299
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.24707
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.21433
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, IGF1R, KDR, MMP9, PIM1, PTGS2, SRC 2.20964
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, PTGS2, PTPRS, SRC, TNKS, XDH 2.20869
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.19661
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.19576
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CSNK2A1, CXCL8, CYP1B1, F10, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PTGS2, PTPRS, SRC, TNKS, TNKS2, XDH 2.18896
[BP] GO:0001101 response to acid chemical AKR1B1, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC 2.15428
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.14735
[BP] GO:0070213 None TNKS, TNKS2 2.12841
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.12841
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.12841
[BP] GO:0006810 None ABCB1, ACHE, ADORA1, ALOX15, ALOX5, APP, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CXCL8, F10, FABP3, MMP12, MMP9, PPARA, SRC, TNKS, XDH 2.07223
[BP] GO:0042493 response to drug ABCB1, AKR1B1, AXL, CA9, CYP1A1, CYP1B1, FABP3, KDR, PTGS2, SRC 2.07195
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.05999
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.03203
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.01794
[BP] GO:0051179 None ABCB1, ACHE, ADORA1, ALOX15, ALOX5, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CXCL8, F10, FABP3, MMP12, MMP9, PPARA, SRC, TNKS, TNKS2, XDH 2.01794
[BP] GO:0051098 regulation of binding APP, AURKB, MET, MMP9, PPARA, SRC, TNKS 2.01746
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, PTGS2, PTPRS, SRC, TNKS, XDH 2.00681
[BP] GO:0031214 biomineral tissue development ALOX15, ALPL, PPARA, PTGS2 2.00202
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA1, ADORA3, ALOX15, ALOX5, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, F10, FLT3, FUT7, HCAR2, HSD17B2, IGF1R, KDR, MET, MMP2, PIM1, PTGS1, PTGS2, PTPRS, SRC, TNKS, TNKS2, TYR 1.8244
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP 1.61682
[CC] GO:0044421 None ABCB1, ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AXL, CA1, CA2, CA4, CA6, CBR1, CXCL8, FABP3, FABP4, MMP1, MMP12, MMP2, MMP9, PTGS1, PTPRS, SRC, TUBB3, XDH 1.55152
[CC] GO:0099055 None ADORA1, PTPRS 1.55152
[CC] GO:0099699 None ADORA1, PTPRS 1.55152
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 17.7703
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RORC, TNKS, TYR, XDH 15.5158
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, F10, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTGS1, PTGS2, PTPRS, SRC, TNKS, TNKS2, TUBB3, TYR, XDH 13.8002
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, F10, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS1, PTGS2, PTPRS, RORC, SRC, TNKS, TNKS2, TUBB3, TYR, XDH 12.2287
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.6662
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.3884
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, HSD17B2, PTGS1, PTGS2, TYR, XDH 7.46457
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, F10, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS1, PTGS2, RORC, TNKS, TNKS2, TYR, XDH 7.30389
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.89281
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, F10, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS1, PTGS2, RORC, TNKS, TNKS2, TYR, XDH 6.89118
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2, SRC 6.84731
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 6.81424
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2, SRC 6.63344
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2, TYR 6.28193
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, XDH 6.17613
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, MMP1, MMP12, MMP2, MMP9, PPARA, RORC, TNKS 6.12398
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 5.48553
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 5.18077
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, PTGS1, PTGS2, SRC, XDH 4.12652
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 4.02821
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.46427
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6 3.09508
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2, XDH 3.0873
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.02602
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, FLT3, IGF1R, KDR, MET, PIM1, PPARA, SRC 2.77771
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.74797
[MF] GO:0008389 None CYP2A13, CYP2A6 2.74797
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.51908
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.35554
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2 2.32989
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX15, ALOX5, PTGS2 2.05999
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX15, ALOX5, PTGS2 2.01794


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 19.346
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 10.0275
Metabolic pathways_Homo sapiens_hsa01100 CBR1, ALOX15, AKR1B1, PTGS2, TYR, CYP19A1, PTGS1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH 5.9355
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2 6.7924
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.2828
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 5.8496
Bladder cancer_Homo sapiens_hsa05219 CXCL8, SRC, MMP1, MMP2, MMP9 5.6657
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, PTGS2, PTGS1 4.8589
Pathways in cancer_Homo sapiens_hsa05200 CXCL8, FLT3, MMP1, MMP2, PTGS2, MMP9, MET, IGF1R 3.6774
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, IGF1R 3.587
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, ALOX15, PTGS2, PTGS1 3.6774
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1, PTGS2, PTGS1 3.6552
Adherens junction_Homo sapiens_hsa04520 CSNK2A1, SRC, MET, IGF1R 3.2731
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.3626
MicroRNAs in cancer_Homo sapiens_hsa05206 ABCB1, PIM1, CYP1B1, PTGS2, MMP9, MET 2.8176
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 CXCL8, FLT3, MMP9, MET, IGF1R 2.8598
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR, PTGS2 2.3062
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.8176
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 CXCL8, SRC, MET 2.212
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1 2.2479
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, IGF1R 1.8294
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 CXCL8, MMP2, PIM1 1.8283
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, IGF1R 1.8283
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9 1.8283
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CXCL8, CSNK2A1, PTGS2 1.8608
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.5725
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 CXCL8, FLT3, KDR, MET 1.5514
Hepatitis B_Homo sapiens_hsa05161 CXCL8, SRC, MMP9 1.5028
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, ADORA1, PPARA 1.2373
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.1285
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3885
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.2888
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.2727
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3715
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.1285
TNF signaling pathway_Homo sapiens_hsa04668 PTGS2, MMP9 0.9952
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2 1.2754
Gap junction_Homo sapiens_hsa04540 SRC, TUBB3 1.1285
Rheumatoid arthritis_Homo sapiens_hsa05323 CXCL8, MMP1 1.1285
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2158
Malaria_Homo sapiens_hsa05144 CXCL8, MET 1.5028
Platelet activation_Homo sapiens_hsa04611 SRC, PTGS1 0.9393
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2 1.2727
Shigellosis_Homo sapiens_hsa05131 CXCL8, SRC 1.3028
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 KDR, MET, IGF1R 0.7953
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 CXCL8, PPARA 0.8
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.9442
Hepatitis C_Homo sapiens_hsa05160 CXCL8, PPARA 0.8807
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9488
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8548
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, PTGS2 0.7953
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.5311
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.768
Chemokine signaling pathway_Homo sapiens_hsa04062 CXCL8, SRC 0.7055
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9352
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.8283
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8254
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, ADORA1 0.5229
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6985
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1 0.3443
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.3328
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.343
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3788
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7849
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3694
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.5017
Influenza A_Homo sapiens_hsa05164 CXCL8 0.3788
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3786
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.4045
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 IGF1R 0.4987
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.3873
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 IGF1R 0.4306
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.4987
Measles_Homo sapiens_hsa05162 CSNK2A1 0.4383
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.5229
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4987
Phagosome_Homo sapiens_hsa04145 TUBB3 0.4097
Prostate cancer_Homo sapiens_hsa05215 IGF1R 0.5017
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4306
Phospholipase D signaling pathway_Homo sapiens_hsa04072 CXCL8 0.4293
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.4424
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4987
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4987
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5017
Small cell lung cancer_Homo sapiens_hsa05222 PTGS2 0.5017
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5351
Insulin resistance_Homo sapiens_hsa04931 PPARA 0.4869
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4598
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4987
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5017
Amoebiasis_Homo sapiens_hsa05146 CXCL8 0.4987
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4987
Salmonella infection_Homo sapiens_hsa05132 CXCL8 0.5017
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.4962
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.4598
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 CXCL8 0.4932
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.5229
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.4844
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5229
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.4699
Glioma_Homo sapiens_hsa05214 IGF1R 0.5351
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5229
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4987
Axon guidance_Homo sapiens_hsa04360 MET 0.4551
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 CXCL8 0.4962
Peroxisome_Homo sapiens_hsa04146 XDH 0.5017
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5017
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.4699
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.4987
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5348
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.543
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5351
Complement and coagulation cascades_Homo sapiens_hsa04610 F10 0.5079
Pertussis_Homo sapiens_hsa05133 CXCL8 0.5229
RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 CXCL8 0.5229
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.5351
Legionellosis_Homo sapiens_hsa05134 CXCL8 0.5653
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 CXCL8 0.5572
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3 0.5653
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.4366
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.6428
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.7235
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.767
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7978
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.768
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7953
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9952


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)